bioRxiv preprint doi: https://doi.org/10.1101/090860; this version posted December 1, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. New genes and functional innovation in mammals José Luis Villanueva-Cañas1,#, Jorge Ruiz-Orera1, Isabel Agea1, Maria Gallo2, David Andreu2, M.Mar Albà1,2,3,* 1Evolutionary Genomics Group, Research Programme in Biomedical Informatics, Hospital del Mar Research Institute (IMIM), Barcelona, Spain; 2Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF), Barcelona, Spain; 3Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Key words: lineage-specific gene, species-specific gene, orphan gene, de novo gene, evolutionary innovation, adaptive evolution, mammals #Current address: Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra), Barcelona, Spain * Corresponding author:
[email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/090860; this version posted December 1, 2016. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. ABSTRACT The birth of genes that encode new proteins is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected for. Here we address this question by generating a comprehensive list of mammalian- specific gene families originated at different times during mammalian evolution.