Curriculum Vitae

Ministerio de Economía y Competitividad. Secretaría de Estado de Investigación, Desarrollo e Innovación

Curriculum Vitae

Name: David Macías Gutiérrez

Date: 19-April-2012

PERSONAL DATA

Family name: Macías Gutiérrez Forename: David Date of birth: 30-01-1981 Gender: Male Nacionality: Spanish

PRESENT PROFESIONAL POSITION

Institution: University of Seville Faculty, School or Institute: Instituto de Biomedicina de Sevilla. IBiS Department: Laboratorio 101. Celullar Neurobiology and Biophysics. Address: Av Manuel Siurot s/n. Complejo Hospitalario Vírgen del Rocio. Edificio IBiS. 41013. Seville. Country: Spain

Telephone (indicate prefix, number and extension): (+34) 955 923033 Fax: E-mail: [email protected],

Field of study (UNESCO codes): 2409, 2415 Profesional status: Postdoctoral researcher Start date: 7-10-2009 Administrative status Permanent Staff Hired on contracts Acting Fellowship holder Others specify:

Full-time Part-time

PRESENT RESEARCH AREA Brief summary (key words). Hypoxia, carotid body, HIF-1pVHL, mitochondrial metabolism, neurodegeneration, lentiviral vectors, genetically modified animal models.

ACADEMIC BACKGROUND

Bachelor Centre Date Degree in Biology University of Jaén 1999-2003 DEA. Molecular and cell biology University of Jaén 2003-2005 program. Master in Basic and Applied Research in Molecular and University of Jaén 2007-2008 Cellular Biology

Ph.D. Centre Thesis Supervisor Date

Francisco Luque Biology University of Jaén 2009 Vázquez

PAST SCIENTIFIC EXPERIENCE (*)

Position R&D Centre Institution (**) Start date End date Ph.D Fellowship University of Jaén 2005 2009 Postdoctoral hired University of Seville 2009 -

(*) The information contained in this chart will be used to verify the placement requirements, according to the section twenty-fourth.3 of the Call. (**) If the Institution is a “joint centre”, you should specify all the centres involved in running it.

LANGUAGES (N = NORMAL, G = GOOD, P = PERFECTLY)

Language Speaking Reading Writing English G P P

PARTICIPATION IN RESEARCH PROJECTS

PROJECT TITLE: CIBER ENFERMEDADES NEURODEGENERATIVAS

FINANCIAL ENTITY: FONDO DE INVESTIGACIÓN SANITARIA (FIS), MINISTERIO DE CIENCIA E INNOVACIÓN LENGHT FROM: 1-1-2010 TO: 31-12-2011 PRINCIPAL INVESTIGATOR: José López Barneo

PROJECT TITLE: SÍNTESIS DE RIBOSOMAS, CÁNCER Y ENFERMEDADES HEREDITARIAS. PAPEL DE LAS PROTEÍNAS RIBOSÓMICAS Y FACTORES DE ENSAMBLAJE DE RIBOSOMAS COMO REGULADORES DE LA PROLIFERACIÓN CELULAR

FINANCIAL ENTITY: PROYECTOS DE EXCELENCIA, JUNTA DE ANDALUCÍA LENGHT FROM: 13-01-2009 TO: 13-01-2013 PRINCIPAL INVESTIGATOR: Jesús de la Cruz Díaz

PROJECT TITLE: Sensibilidad al oxígeno y neurodegeneración

FINANCIAL ENTITY: OTROS PROGRAMAS, ORGANISMOS PRIVADOS (EXTERNOS LENGHT FROM: 1-1-2007 TO: 31-12-2012 PRINCIPAL INVESTIGATOR: José López Barneo

PUBLICATIONS

Key: B= full book, CB.= chapter of book, A= article, R= review, E= editor (*) Those publications in process and not yet published, just specify publication status. (**)When applicable/available

AUTHORS (in order of authorship): Ana Fernández-Ocaña, Mari Carmen García-López, Jaime Jiménez- Ruiz, Luisa Saniger, David Macías, Francisco Navarro, Ricardo Oya, Angjelina Belaj, Raul de la Rosa, Francisco J. Corpas, Juan Bautista Barroso, Francisco Luque. TITLE: Identification of a gene involved in the juvenile-to-adult transition (JAT) in cultivated olive trees.

JOURNAL/BOOK TITLE: Tree Genetics & Genomes KEY: A VOLUME: 6 FIRST AND LAST PAGE: 891-903 DATE OF PUBLICATION (*): 2010 JOURNAL WITHIN THE 25% HIGHER IMPACT FACTOR IN ITS KNOWLEDGE AREA AT THE YEAR OF PUBLICATION (**): YES NO IMPACT FACTOR (**): 2,018 TOTAL NUMBER OF TIMES CITED: 0

AUTHORS (in order of authorship): Macías, D. Oya, R. Saniger, L. Martín, F. Luque, F. TITLE: A lentiviral vector that activates latent HIV-1 proviruses by the overexpression of Tat and that kills the infected cells.

JOURNAL/BOOK TITLE: Human Gene Therapy KEY: A VOLUME: 20 FIRST AND LAST PAGE: 1259-1268 DATE OF PUBLICATION (*): 2009 JOURNAL WITHIN THE 25% HIGHER IMPACT FACTOR IN ITS KNOWLEDGE AREA AT THE YEAR OF PUBLICATION (**): YES NO IMPACT FACTOR (**): 4,82 TOTAL NUMBER OF TIMES CITED: 1

AUTHORS (in order of authorship): Saniger, L. Oya, R. Macías, D. Domínguez, J.N. Aránega, A. Luque, F. TITLE: c-Jun Kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA.

JOURNAL/BOOK TITLE: Journal of Cellular biochemistry KEY: A VOLUME: 98 FIRST AND LAST PAGE: 650-660 DATE OF PUBLICATION (*): 2006 JOURNAL WITHIN THE 25% HIGHER IMPACT FACTOR IN ITS KNOWLEDGE AREA AT THE YEAR OF PUBLICATION (**): YES NO IMPACT FACTOR (**): 3,409 TOTAL NUMBER OF TIMES CITED: 0

AUTHORS (in order of authorship): Luque, F. Oya, R. Macías, D. Saniger, L. TITLE: Gene therapy of HIV-1 infection: Are lethal genes a valuable tool?

JOURNAL/BOOK TITLE: Cellular and Molecular Biology KEY: R VOLUME: 51 FIRST AND LAST PAGE: 93-101 DATE OF PUBLICATION (*): 2005 JOURNAL WITHIN THE 25% HIGHER IMPACT FACTOR IN ITS KNOWLEDGE AREA AT THE YEAR OF PUBLICATION (**): YES NO IMPACT FACTOR (**): 1,018 TOTAL NUMBER OF TIMES CITED: 4

STAYS IN INTERNATIONALLY RECOGNIZED CENTRES

KEY: D=Ph.D student, P=postdoctoral. G= guest, S=staff, O=others (specify)

CENTRE: Institute of Parasitology and Biomedicine "López-Neyra". PLACE: Granada COUNTRY: Spain YEAR: 2008 LENGHT: 6 month TOPIC: Development of lentiviral vectors for a HIV-1 gene therapy approach. KEY: D

PRESENTATIONS IN CONGRESSES

AUTHORS: David Macías and José López-Barneo. TITLE: Ablation of Vhl in tyrosine hydroxylase positive cells results in abnormal sympathoadrenal development and altered acclimatization to chronic hypoxia

TYPE OF PRESENTATION: poster CONGRESS: Keystone Symposia: Advances in hypoxic Signaling: From Bench to Bedside PUBLICATION:

MEETING PLACE: Banff, Alberta. Canada YEAR: 2012

AUTHORS: Ana María Fernández Ocaña; Mª del Carmen García López; Jaime Jiménez Ruiz; Luisa Saniger Bernal; David Macías Gutiérrez; Francisco Navarro Gómez; Ricardo Oya Aponte; Raul de la Rosa Navarro; Francisco Javier Corpas Aguirre; Juan Bautista Barroso Albarracín; Francisco Luque Vázquez.

TITLE: A gene Required for a Non-Delayed Juvenile to Adult Transition in Cultivated Olive Trees. TYPE OF PRESENTATION: short presentation CONGRESS: 28th Internacional Horticultural Congress PUBLICATION:

MEETING PLACE: Lisboa YEAR: 2010

AUTHORS: Mª del Carmen García López; Jaime Jiménez Ruiz; David Macías Gutiérrez; Ana María Fernández Ocaña; Juan Bautista Barroso Albarracin; Angjelina Belaj ; Raul de la Rosa Navarro; Francisco Javier Corpas Aguirre; Francisco Luque Vázquez.

TITLE: A gene that affects Arabidopsis thaliana primary root, rosette leaves and floral stem development. TYPE OF PRESENTATION: poster CONGRESS: Plant Growth Biology and Modelling Workshop. PUBLICATION:

MEETING PLACE: Elche (Spain) YEAR: 2009

AUTHORS: Jaime Jiménez Ruiz; Mª del Carmen García López; Ana María Fernández Ocaña; David Macías Gutiérrez; Raul de la Rosa Navarro; Juan Bautista Barroso Albarracin; Francisco Luque Vázquez.

TITLE: Estructura genética, análisis filogenético y de expresión del gen (JAT) implicado en la transición juvenil-adulto del olivo. TYPE OF PRESENTATION: Oral presentation CONGRESS: XXXVII Congreso de la Sociedad Española de Genética. PUBLICATION:

MEETING PLACE: Torremolinos, Málaga (Spain) YEAR: 2009

AUTHORS: Ana María Fernández Ocaña; David Macías Gutiérrez; Mª del Carmen García López; Jaime Jiménez Ruiz; Raul de la Rosa Navarro; Juan Bautista Barroso Albarracin; Francisco Javier Corpas Aguirre; Francisco Luque Vázquez.

TITLE: Identificación de un gen implicado en la transición juvenil a adulto en el olivo cultivado. TYPE OF PRESENTATION: Poster CONGRESS: XXXII Congreso de la Sociedad Española de Bioquímica y Biología Molecular. PUBLICATION:

MEETING PLACE: Oviedo (Spain) YEAR: 2009

AUTHORS: David Macías Gutiérrez; Ricardo Antonio Oya Aponte; María Luisa Saniger Bernal; Francisco Martín Molina; Francisco Luque Vázquez..

TITLE: A lentiviral vector that activates latent HIV-1 proviruses by the overexpression of tat and that kills the infected cells. TYPE OF PRESENTATION: Poster CONGRESS: Vth Biennial Congress of the Spanish Society of Gene and Cell Therapy. PUBLICATION:

MEETING PLACE: Granada (Spain) YEAR: 2009

AUTHORS: David Macías Gutiérrez; Ricardo Antonio Oya Aponte; Francisco José Sánchez Luque; Francisco Martín Molina; Francisco Luque Vázquez.

TITLE: A lentiviral vector for regulated tat expression activates HIV-1 silent proviruses in latently infected cells. TYPE OF PRESENTATION: Poster CONGRESS: XVIth Annual Congress of the European Society of Gene and Cell Therapy. PUBLICATION:

MEETING PLACE: Brugge (Belgium) YEAR: 2008

AUTHORS: Ana María Fernández Ocaña; María Luisa Saniger Bernal; David Macías Gutiérrez; Francisco Navarro Gómez; Ricardo Antonio Oya Aponte; Alfonso Carreras Egaña; Araceli Barceló Muñoz; R de la Rosa; Juan Bautista Barroso Albarracin; Francisco Luque Vázquez.

TITLE: Un gen potencialmente implicado en la transición juvenil-adulto en el olivo cultivado. TYPE OF PRESENTATION: Poster CONGRESS: IX Reunión de Biología Molecular de Plantas.. PUBLICATION:

MEETING PLACE: Santiago de Compostela (Spain) YEAR: 2008

TITLE: Búsqueda de genes implicados en la transición juvenil vegetativa a adulta en el olivo (olea europaea L.) TYPE OF PRESENTATION: Poster CONGRESS: XXXVI Congreso de la Sociedad Española de Genética. PUBLICATION:

MEETING PLACE: León (Spain) YEAR: 2007

AUTHORS: M. J. Ramírez, R. Oya, M. P. Carrera, M. Cobo, D. Macias, S. De la Chica, P. Cortés y J. M. Martínez.

TITLE: El enzima Pirrolidón carboxil peptidasa protege a células de neuroblastoma humano (NB69) en cultivo de la neurotoxicidad producida por las formas piroglutamilo-terminales del β-amiloide. TYPE OF PRESENTATION: Poster CONGRESS: V Conferencia Nacional Alzheimer PUBLICATION:

MEETING PLACE: Murcia (Spain) YEAR: 2005

AUTHORS: R. Oya, D. Macías, L. Saniger y F. Luque.

TITLE: Vector lentiviral para la destrucción selectiva de células con provirus latentes: posible uso en terapia génica contra el VIH-1. TYPE OF PRESENTATION: Poster CONGRESS: 1er Congreso Español en Farmacogenética y Farmacogenómica PUBLICATION:

MEETING PLACE: Valencia (Spain) YEAR: 2005