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Supplemental Table 3

Supplemental Table 3

Supplemental Table 3. Min_max_span_internal Reactions minWT maxWTspanWTminKO maxKO spanKOspanKO/spanWTName Equation Subsystem 2HBO -2 0 2 -3 0 3 1.5 2-Hydroxybutyrate:NAD+[c] : 2hb + nad oxidoreductasePropanoate <==> 2obut + h + nadh 2HBt2 -2 0 2 -3 0 3 1.5 2-hydroxybutyrate2hb[e] cotransport + h[e] <==>Transport, with 2hb[c] proton Extracellular + h[c] 2MCITt 0 2 2 0 3 3 1.5 2-methylcitrate2mcit[c] transport <==> via Transport,2mcit[e] diffusion Extracellular 34HPLFM 0 1 1 0 2 2 2 3-(4-hydroxyphenyl-)lactate[m] : 34hpp + Ubiquinoneh formation + nadh --> Biosynthesis34hpl + nad 3DSPHR 0 1 1 0 37.54 37.54 37.536 3-Dehydrosphinganine[c] : 3dsphgn +Sphingolipid h + nadph --> Metabolism nadp + sphgn 4HOXPACDOX(NADP) 0 1 1 0 2 2 2 4-Hydroxyphenylacetaldehyde:NADP+[c] : 4hoxpacdTyrosine + h2o + nadpmetabolism <==> 4hphac + (2) h + nadph AACTOOR 0 2 2 0 24.58 24.58 12.291 Aminoacetone:[c] : aact +oxidoreductase(deaminating)(flavin-containing) h2oGly, + o2 Ser, --> Thr h2o2 Metabolism + mthgxl + nh4 AACTtm 0 2 2 0 24.58 24.58 12.291 Aminoacetoneaact[m] transport --> (mitochondrial)aact[c]Transport, Mitochondrial ACACt2m -217 260.7 478.1 -219 149.7 368.6 0.771 Acetoacetate acac[c]mitochondrial + h[c] Transport,<==> transport acac[m] viaMitochondrial +H+ h[m] symport ACACtx -254 0 254.4 -130 0 129.9 0.5105 acetoacetate intracellularacac[c] <==> transport acac[x]Transport, unknown Peroxisomal mechanism ACGAMtly 0 56.44 56.44 0 5 5 0.0886 N-acetyl-glucosamineacgam[l] lysosomal --> acgam[c]Transport, efflux Lysosomal ADK3m 0 4.6 4.6 0 16.41 16.41 3.5666 adentylate kinase[m] :(GTP) amp + gtpNucleotides <==> adp + gdp ADNK1m 0 4.6 4.6 0 16.41 16.41 3.5666 adenosine kinase,[m] :mitochondrial adn + atpNucleotides --> adp + amp + h ADNtm 0 4.6 4.6 0 16.41 16.41 3.5666 adenosine facilatedadn[c] transport <==> adn[m]Transport, in mitochondria Mitochondrial ADSL2 0 2 2 0 10.51 10.51 5.2563 adenylosuccinate[c] : lyase25aics -->IMP aicar Biosynthesis + fum AHC 0 2 2 0 3 3 1.5 adenosylhomocysteinase[c] : ahcys + h2oMethionine <==> adn Metabolism+ hcys-L AICART 0 2 2 0 10.51 10.51 5.2563 phosphoribosylaminoimidazolecarboxamide[c] : 10fthf + aicarIMP <==>Biosynthesis fprica + formyltransferase thf AIRCr 0 2 2 0 10.51 10.51 5.2563 phosphoribosylaminoimidazole[c] : air + co2 <==>IMP carboxylase Biosynthesis5aizc + h AKGMALtm -708 5E+05 5E+05 -710 170 879.9 0.0018 alpha-ketoglutarate/malateakg[m] + mal-L[c]Transport, transporter <==> akg[c] Mitochondrial + mal-L[m] ALCD1 -2 0 2 -3 0 3 1.5 [c] : meoh (methanol) + nadMiscellaneous <==> fald + h + nadh AOBUTDsm 0 2 2 0 24.58 24.58 12.291 L-2-amino-3-oxobutanoate[m] : 2aobut + Gly,decarboxylation, h --> Ser, aact Thr + co2Metabolism mitochondrial BETALDHxm 0 1 1 0 2 2 2 betaine-aldehyde[m] :dehydrogenase, betald + Gly,h2o Ser,+ nad mitochondrial Thr --> Metabolism glyb + (2) h + nadh BHMT 0 1 1 0 2 2 2 betaine-homocysteine[c] : glyb +S-methyltransferase hcys-LGly, --> Ser, dmgly Thr Metabolism + met-L BPNT 0 1 1 0 2 2 2 3',5'-bisphosphate[c] : h2o nucleotidase + papNucleotides --> amp + pi BUP2 0 1.3 1.3 0 27.65 27.65 21.268 beta-ureidopropionase[c] : 3uib +(D-3-amino-isobutanoate (2)Pyrimidine h + h2o --> Catabolism 3aib-D + co2 forming) + nh4 CAMPt 0 3.3 3.3 0 9.45 9.45 2.8636 cAMP transportatp[c] (ATP-dependent) + camp[c]Transport, + h2o[c] Extracellular --> adp[c] + camp[e] + h[c] + pi[c] CGMPt 0 0.15 0.15 0 9.45 9.45 63 cGMP transport35cgmp[c] (ATP-dependent) + atp[c]Transport, + h2o[c] Extracellular --> 35cgmp[e] + adp[c] + h[c] + pi[c] CHLtm 0 1 1 0 2 2 2 choline transportchol[c] via <==>diffusion chol[m]Transport, (cytosol Mitochondrialto mitochondria) CHOLD2m 0 1 1 0 2 2 2 [m] : chol (FAD+ fadGly, acceptor),--> Ser, betald Thr + mitochondrialMetabolism fadh2 CHOLtu 0 1 1 -0.33 1 1.333 1.3333 Choline uniportchol[e] <==> chol[c]Transport, Extracellular CLFORtex 0 1 1 0 1.5 1.5 1.5 chloride transportcl[e] via+ (2) formate for[c]Transport, --> countertransport cl[c] + Extracellular (2) for[e] COAtm -108 234.8 342.7 -108 0 108.2 0.3158 CoA transportercoa[c] <==> coa[m]Transport, Mitochondrial COAtp -254 0 254.4 -130 0 129.9 0.5105 coenzyme A transport,coa[c] <==> peroxisomal coa[x]Transport, Peroxisomal CRNCARtp 0 254.4 254.4 0 129.9 129.9 0.5105 carnitine-acetylcarnitineacrn[x] + crn[c] carrier,Transport, --> acrn[c]peroxisomal Peroxisomal + crn[x] CSNATp 0 254.4 254.4 0 129.9 129.9 0.5105 carnitine O-acetyltransferase,[x] : accoa + crnFatty <==>reverse Acid acrn Metabolismdirection, + coa peroxisomal CYTDt -1.15 0.15 1.3 -13.2 0.15 13.35 10.269 cytidine facilatedcytd[e] transport <==> cytd[c] Transport,in cytosol Extracellular D-3AIBt 0 1.3 1.3 0 27.65 27.65 21.268 D-3-amino-isobutyrate3aib-D[c] transport--> 3aib-D[e]Transport, Extracellular DATPtn 0 3.3 3.3 0 9.45 9.45 2.8636 dATP diffusiondatp[c] in nucleus <==> datp[n]Transport, Nuclear DCTPtn 0 1.3 1.3 0 13.35 13.35 10.269 dCTP diffusiondctp[c] in nucleus <==> dctp[n]Transport, Nuclear DCYTt -1.3 0 1.3 -13.4 0 13.35 10.269 deoxycytidinedcyt[e] transport <==> via dcyt[c] Transport,diffusion Extracellular DGK1 -4.6 0 4.6 -16.5 0 16.46 3.5779 deoxyguanylate[c] kinase: atp + (dGMP:ATP)dgmpNucleotides <==> adp + dgdp DGK2m 0 4.6 4.6 0 16.33 16.33 3.5507 deoxyguanylate[m] kinase : datp (dGMP:dATP) + dgmpNucleotides <==> (mitochondrial)dadp + dgdp DGNSKm 0 4.6 4.6 0 16.33 16.33 3.5507 deoxyguanosine[m] kinase : atp + dgsnNucleotides --> adp + dgmp + h DGSNt -0.15 0 0.15 -9.45 0 9.45 63 deoyguanosinedgsn[e] transport <==> via dgsn[c]Transport, diffusion Extracellular DGSNtm 0 4.6 4.6 0 16.33 16.33 3.5507 deoyguanosinedgsn[c] transport <==> in dgsn[m] Transport,mitochondria Mitochondrial DGTPtn 0 0.15 0.15 0 9.45 9.45 63 dGTP diffusiondgtp[c] in nucleus <==> dgtp[n]Transport, Nuclear DHCRD1 0 1 1 0 37.31 37.31 37.309 dihydroceramide[c] : desaturasedhcrm_hsSphingolipid + nadp --> crm_hs Metabolism + h + nadph DHFR 0 1.3 1.3 0 27.65 27.65 21.268 dihydrofolate [c]reductase : dhf + h + nadphFolate <==>Metabolism nadp + thf DHPM1 0 1.3 1.3 0 47.17 47.17 36.287 [c] : 56dura (5,6-dihydrouracil) + Pyrimidineh2o --> cala Catabolism + h DHPM2 0 1.3 1.3 0 27.65 27.65 21.268 dihydropyrimidinase[c] : 56dthm (dihydrothymine) +Pyrimidine h2o --> 3uib Catabolism + h DMGDHm 0 1 1 0 2 2 2 dimethylglycine[m] dehydrogenase, : dmgly + fadGly, + Ser, mitochondrialh2o Thr --> Metabolismfadh2 + fald + sarcs DMGtm 0 1 1 0 2 2 2 dimethylglycinedmgly[c] transport <==> viaTransport, dmgly[m] diffusion Mitochondrial(cytosol to mitochondria) DNDPt12m 0 4.6 4.6 0 16.41 16.41 3.5666 dADP transportadp[m] via ADP + dadp[c] antiportTransport, --> adp[c] Mitochondrial + dadp[m] DNDPt13m 0 4.6 4.6 0 16.41 16.41 3.5666 dADP transportatp[m] via ATP + dadp[c] antiportTransport, --> atp[c] Mitochondrial + dadp[m] DNDPt18m 0 4.6 4.6 0 16.41 16.41 3.5666 dUDP transportadp[m] via ADP + dudp[c] antiportTransport, --> adp[c] Mitochondrial + dudp[m] DNDPt19m 0 4.6 4.6 0 16.41 16.41 3.5666 dUDP transportatp[m] via ATP + dudp[c] antiportTransport, --> atp[c] Mitochondrial + dudp[m] DNDPt1m 0 3.95 3.95 0 10.27 10.27 2.5995 dATP transportadp[m] via ADP + datp[c]antiportTransport, --> adp[c] Mitochondrial + datp[m] DNDPt20m 0 4.6 4.6 0 16.41 16.41 3.5666 dTDP transportatp[m] via ATP + dtdp[c] antiportTransport, --> atp[c] Mitochondrial + dtdp[m] DNDPt21m 0 4.6 4.6 0 16.41 16.41 3.5666 dTDP transportadp[m] via ADP + dtdp[c] antiportTransport, --> adp[c] Mitochondrial + dtdp[m] DNDPt2m 0 3.95 3.95 0 10.27 10.27 2.5995 dATP transportatp[m] via ATP + datp[c] antiportTransport, --> atp[c] Mitochondrial + datp[m] DNDPt30m 0 4.6 4.6 0 16.41 16.41 3.5666 dCDP transportadp[m] via ADP + dcdp[c] antiportTransport, --> adp[c] Mitochondrial + dcdp[m] DNDPt31m 0 4.6 4.6 0 16.41 16.41 3.5666 dCDP transportatp[m] via ATP + dcdp[c] antiportTransport, --> atp[c] Mitochondrial + dcdp[m] DNDPt32m 0 4.6 4.6 0 16.41 16.41 3.5666 dGDP transportatp[m] via ATP + dgdp[c] antiportTransport, --> atp[c] Mitochondrial + dgdp[m] DNDPt3m 0 7.9 7.9 0 20.48 20.48 2.5925 dATP transportdatp[c] via dCDP + dcdp[m] antiportTransport, --> datp[m] Mitochondrial + dcdp[c] DNDPt44m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportatp[m] via ATP + dttp[c]antiportTransport, --> atp[c] Mitochondrial + dttp[m] DNDPt45m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportadp[m] via ADP + dttp[c]antiportTransport, --> adp[c] Mitochondrial + dttp[m] DNDPt46m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportdttp[c] via dUDP + dudp[m] antiportTransport, --> dttp[m] Mitochondrial + dudp[c] DNDPt47m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportdtdp[m] via dTDP + dttp[c]antiportTransport, --> dtdp[c] Mitochondrial + dttp[m] DNDPt48m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportdgdp[m] via dGDP + dttp[c]antiportTransport, --> dgdp[c] Mitochondrial + dttp[m] DNDPt49m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportdadp[m] via dADP + dttp[c]antiportTransport, --> dadp[c] Mitochondrial + dttp[m] DNDPt4m 0 7.9 7.9 0 20.48 20.48 2.5925 dATP transportdatp[c] via dUDP + dudp[m] antiportTransport, --> datp[m] Mitochondrial + dudp[c] DNDPt50m 0 1.3 1.3 0 14.91 14.91 11.472 dTTP transportdcdp[m] via dCDP + dttp[c]antiportTransport, --> dcdp[c] Mitochondrial + dttp[m] DNDPt51m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportdcdp[m] via dCDP + dctp[c]antiportTransport, --> dcdp[c] Mitochondrial + dctp[m] DNDPt52m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportdctp[c] via dUDP + dudp[m] antiportTransport, --> dctp[m] Mitochondrial + dudp[c] DNDPt53m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportdctp[c] via dGDP + dgdp[m] antiportTransport, --> dctp[m] Mitochondrial + dgdp[c] DNDPt54m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportdadp[m] via dADP + dctp[c]antiportTransport, --> dadp[c] Mitochondrial + dctp[m] DNDPt55m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportadp[m] via ADP + dctp[c]antiportTransport, --> adp[c] Mitochondrial + dctp[m] DNDPt56m 0 1.3 1.3 0 13.35 13.35 10.269 dCTP transportatp[m] via ATP + dctp[c] antiportTransport, --> atp[c] Mitochondrial + dctp[m] DNDPt57m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportatp[m] via ATP + dgtp[c] antiportTransport, --> atp[c] Mitochondrial + dgtp[m] DNDPt58m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportadp[m] via ADP + dgtp[c] antiportTransport, --> adp[c] Mitochondrial + dgtp[m] DNDPt59m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportdadp[m] via dADP + dgtp[c] antiportTransport, --> dadp[c] Mitochondrial + dgtp[m] DNDPt5m 0 7.9 7.9 0 20.48 20.48 2.5925 dATP transportdatp[c] via dTDP + dtdp[m] antiportTransport, --> datp[m] Mitochondrial + dtdp[c] DNDPt60m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportdgtp[c] via dUDP + dudp[m] antiportTransport, --> dgtp[m] Mitochondrial + dudp[c] DNDPt61m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportdgtp[c] via dTDP + dtdp[m] antiportTransport, --> dgtp[m] Mitochondrial + dtdp[c] DNDPt62m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportdgdp[m] via dGDP + dgtp[c] antiportTransport, --> dgdp[c] Mitochondrial + dgtp[m] DNDPt63m 0 0.15 0.15 0 9.45 9.45 63 dGTP transportdcdp[m] via dCDP + dgtp[c] antiportTransport, --> dcdp[c] Mitochondrial + dgtp[m] DNDPt6m 0 7.9 7.9 0 20.48 20.48 2.5925 dATP transportdatp[c] via dGDP + dgdp[m] antiportTransport, --> datp[m] Mitochondrial + dgdp[c] DNDPt7m 0 7.9 7.9 0 20.48 20.48 2.5925 dATP transportdadp[m] via dADP + datp[c]antiportTransport, --> dadp[c] Mitochondrial + datp[m] DOPAtu ##### 388.4 5E+05 0 389.6 389.6 0.0008 Dopamine uniportdopa[e] <==> Transport,dopa[c] Extracellular DSAT 0 1 1 0 37.31 37.31 37.309 dihydrosphingosine[c] : Rtotalcoa N-acyltransferaseSphingolipid + sphgn --> coaMetabolism + dhcrm_hs + h DTMPK 0 1.3 1.3 0 15.67 15.67 12.051 dTMP kinase [c] : atp + dtmpNucleotides <==> adp + dtdp DTTPtn 0 1.3 1.3 0 15.67 15.67 12.051 dTTP diffusiondttp[c] in nucleus <==> dttp[n]Transport, Nuclear DURAD -1.3 0 1.3 -47.2 0 47.17 36.287 dihydrouracil dehydrogenase[c] : 56dura + Pyrimidinenadp (NADP) <==> hCatabolism + nadph + ura DURAD2 -1.3 0 1.3 -27.6 0 27.65 21.268 dihydrothymin[c] dehydrogenase : 56dthm +Pyrimidine nadp (NADP) <==> Catabolismh + nadph + thym DURIPP -1.3 0 1.3 -27.8 0 27.78 21.371 deoxyuridine phosphorylase[c] : duri + pi <==>Nucleotides 2dr1p + ura DURIt -1.3 0 1.3 -19.7 0 19.74 15.188 deoxyuridine transportduri[e] <==> via duri[c]diffusionTransport, Extracellular FACOAL160i 0 22.48 22.48 0 38.31 38.31 1.7043 C160 fatty acid[c] activation : atp + coa Fatty+ hdca acid --> activationamp + pmtcoa + ppi FALDH -1 1 2 -1 2 3 1.5 formaldehyde[c] dehydrogenase : fald + gthrdTyrosine + nad <==>metabolism Sfglutth + h + nadh FALDtm 0 1 1 0 2 2 2 formaldehydefald[m] transport <==> via fald[c] Transport,diffusion (mitochondrial) Mitochondrial FORt2m -2 0 2 -3 0 3 1.5 formate mitochondrialfor[m] <==> transport for[c]Transport, Mitochondrial FTHFL 0 2 2 0 3 3 1.5 formate-tetrahydrofolate[c] : atp + for + thf <==> Metabolism 10fthf + adp + pi FTHFLm 0 2 2 0 3 3 1.5 formate-tetrahydrofolate[m] : atp + for ligase,Folate + thf mitochondrial<==> Metabolism 10fthf + adp + pi GARFT 0 2 2 0 10.51 10.51 5.2563 phosphoribosylglycinamide[c] : 10fthf + gar IMPformyltransferase <==> Biosynthesis fgam + h + thf GLUPRT 0 2 2 0 10.51 10.51 5.2563 glutamine phosphoribosyldiphosphate[c] : gln-L + h2oIMP + prpp Biosynthesis --> amidotransferase glu-L + ppi + pram GLUt2m -562 5E+05 5E+05 -565 160.6 725.3 0.0014 L-glutamate reversibleglu-L[c] + transporth[c] Transport,<==> viaglu-L[m] proton Mitochondrial + symport,h[m] mitochondrial GLYATm 0 2 2 0 24.58 24.58 12.291 glycine C-acetyltransferase[m] : accoa + glyGly, <==> Ser, 2aobutThr Metabolism + coa GLYBtm 0 1 1 0 2 2 2 Glycine betaineglyb[m] transport <==> via glyb[c]Transport, diffusion Mitochondrial(mitochondria to cytosol) GLYOp 0 2 2 0 26.22 26.22 13.112 glycine ,[x] perixosomal : gly + h2o Gly,+ o2 Ser, --> glxThr + Metabolism h2o2 + nh4 GLYtm -3 1 4 -3 24.58 27.58 6.8953 glycine passivegly[c] transport <==> gly[m]to Transport,mitochondria Mitochondrial GLYtp 0 2 2 0 26.22 26.22 13.112 glycine passivegly[c] transport <==> gly[x]to Transport,peroxisome Peroxisomal GMPR 0 0.15 0.15 0 86.92 86.92 579.45 GMP reductase[c] : gmp + (2) h + nadph --> imp + nadp + nh4 GSNt 0 0.15 0.15 -9.3 0.15 9.45 63 facilatedgsn[e] transport<==> gsn[c]Transport, in cytosol Extracellular GUAD 0 0.15 0.15 0 11.81 11.81 78.75 deaminase[c] : gua + h + Purineh2o --> Catabolism nh4 + xan H2Otly 0 110.9 110.9 0 9 9 0.0812 H2O transport,h2o[c] lysosomal <==> h2o[l]Transport, Lysosomal HDCAter 0 1 1 0 37.31 37.31 37.309 palmitate ER exporthdca[r] --> hdca[c]Transport, ER HMGCOAtm -235 107.9 342.7 0 108.2 108.2 0.3158 Hydroxymethylglutaryl-CoAhmgcoa[c] <==>Transport, reversible hmgcoa[m] Mitochondrialmitochondrial transport HMGCOAtx 0 254.4 254.4 0 129.9 129.9 0.5105 Hydroxymethylglutaryl-CoAhmgcoa[c] <==>Transport, reversible hmgcoa[x] Peroxisomalperoxisomal transport HMGLm 0 296.8 296.8 0 108.2 108.2 0.3646 hydroxymethylglutaryl-CoA[m] : hmgcoa Cholesterol-->lyase acac + accoa Metabolism HMGLx 0 254.4 254.4 0 129.9 129.9 0.5105 hydroxymethylglutaryl-CoA[x] : hmgcoa --> Cholesterollyase acac + accoa Metabolism HPACtr 0 1 1 0 2 2 2 hydroxyphenylacetate4hphac[c] transport <==>Transport, 4hphac[e] via diffusion Extracellular HXANtx 0 3.3 3.3 0 11.81 11.81 3.5795 hxan[c]diffusion --> in hxan[x] peroxisomeTransport, Peroxisomal ILEtec 0 1 1 ##### 0.568 5E+05 500001 L-isoleucine transportile-L[e] <==> via diffusion ile-L[c]Transport, (extracellular Extracellular to cytosol) IMPC -2 0 2 -10.5 0 10.51 5.2563 IMP cyclohydrolase[c] : h2o + impIMP <==> Biosynthesis fprica MCITS 0 2 2 0 3 3 1.5 2-methylcitrate[c] synthase : h2o + oaaPropanoate + ppcoa --> Metabolism2mcit + coa + h MEOHt2 -2 0 2 -3 0 3 1.5 Methanol diffusionmeoh[e] <==>Transport, meoh[c] Extracellular METAT 0 2 2 0 3 3 1.5 methionine adenosyltransferase[c] : atp + h2oMethionine + met-L --> ametMetabolism + pi + ppi MTHFC -1.3 2 3.3 -5 20.36 25.36 7.6843 methenyltetrahydrofolate[c] : h2o + methf cyclohydrolaseFolate <==> Metabolism 10fthf + h MTHFD -1.3 0 1.3 -7 18.53 25.53 19.635 methylenetetrahydrofolate[c] : mlthf + nadp Folatedehydrogenase <==> Metabolism methf +(NADP) nadph NDPK4 0 1.3 1.3 0 15.67 15.67 12.051 -diphosphate[c] : atp + dtdp kinaseNucleotides <==> (ATP:dTDP) adp + dttp NRPPHRtu ##### 388.4 5E+05 0 389.6 389.6 0.0008 Norepinephrinenrpphr[e] uniport <==>Transport, nrpphr[c] Extracellular NTD8 0 4.6 4.6 0 16.46 16.46 3.5779 5'-nucleotidase[c] (dGMP) : dgmp + h2oNucleotides --> dgsn + pi OBDHc 0 2 2 0 3 3 1.5 2-Oxobutanoate[c] :dehydrogenase, 2obut + coaGly, + Ser,nad cytosolic Thr--> co2Metabolism + nadh + ppcoa OCOAT1m -221 289.9 511.3 -223 150.4 373.4 0.7301 3-oxoacid CoA-[m] : acac + succoaVal, Leu, <==> ileu aacoa Metabolism + succ PIt2m_2 ##### 540 5E+05 -236 542 777.9 0.0016 PIt2m_2 (2) h[c] + pi[c]Oxidative <==> (2) h[m]Phosphorylation + pi[m] PIt9 -3 24.83 27.83 -3 54.19 57.19 2.0554 phosphate transport(2) na1[e] in/out + pi[e] Transport,via <==>two Na+ (2) Extracellular na1[c] symporter + pi[c] PRAGSr 0 2 2 0 10.51 10.51 5.2563 phosphoribosylglycinamide[c] : atp + gly + IMPsynthase pram Biosynthesis <==> adp + gar + h + pi PRAIS 0 2 2 0 10.51 10.51 5.2563 phosphoribosylaminoimidazole[c] : atp + fpramIMP --> synthaseBiosynthesis adp + air + (2) h + pi PRASCS 0 2 2 0 10.51 10.51 5.2563 phosphoribosylaminoimidazolesuccinocarboxamide[c] : 5aizc + asp-LIMP + Biosynthesis atp <==> 25aics + adp synthase + h + pi PRFGS 0 2 2 0 10.51 10.51 5.2563 phosphoribosylformylglycinamidine[c] : atp + fgamIMP + gln-L Biosynthesis synthase+ h2o --> adp + fpram + glu-L + h + pi PSDm_hs 0 1 1 0 5.5 5.5 5.5 Phosphatidylserine[m] : hdecarboxylase + ps_hsGlycerophospholipid --> co2 + pe_hs Met. PSFLIPm 0 1 1 0 5.5 5.5 5.5 phosphatidylserineatp[c] flippase + h2o[c]Transport, + ps_hs[c] Mitochondrial --> adp[c] + h[c] + pi[c] + ps_hs[m] PYNP2r 0 1.3 1.3 0 47.29 47.29 36.378 pyrimidine-nucleoside[c] : pi + uriphosphorylase <==>Pyrimidine r1p + ura (uracil) Catabolism RNDR2 0 0.15 0.15 0 9.45 9.45 63 ribonucleoside-diphosphate[c] : gdp + trdrdNucleotides reductase --> dgdp +(GDP) h2o + trdox SADT 0 1 1 0 2 2 2 sulfate adenylyltransferase[c] : atp + h + so4Nucleotides --> aps + ppi SERPT 0 1 1 0 37.54 37.54 37.536 serine C-palmitoyltransferase[c] : h + pmtcoaSphingolipid + ser-L --> Metabolism3dsphgn + co2 + coa SFGTH -1 1 2 -1 2 3 1.5 S-Formylglutathione[c] : Sfglutth hydralase + h2o <==> metabolism for + gthrd + h SGPL12r 0 1 1 0 37.31 37.31 37.309 Sphingosine-1-phosphate[r] : h2o + sphs1p lyaseSphingolipid --> ethamp Metabolism + h + hdca SLCBK1 0 1 1 0 9.255 9.255 9.2546 sphingolipid long[c] : chain atp + basesphgnSphingolipid kinase --> adp (sphinganine) + h Metabolism + sph1p SMPD4 0 1 1 0 37.31 37.31 37.309 sphingomyelinase[c] : h2o + spc_hsSphingolipid --> cholp Metabolism + h + sphings SMS 0 1 1 0 37.31 37.31 37.309 Sphingomyelin[c] synthase : crm_hs (homo + Sphingolipidpchol_hs sapiens) --> Metabolismdag_hs + sphmyln_hs SPC_HSt 0 1 1 0 1.333 1.333 1.3333 sphingosylphosphorylcholinespc_hs[c] <==>Transport, spc_hs[e]transport Extracellular (diffusion) SPH1Pte 0 1 1 0 9.255 9.255 9.2546 sph1p transportsph1p[c] <==>Transport, sph1p[e] Extracellular SPHK21c 0 1 1 0 37.31 37.31 37.309 sphingosine kinase[c] : atp 2 + sphingsSphingolipid --> adp + Metabolism h + sphs1p SPHMDAc 0 1 1 0 37.31 37.31 37.309 sphingomyelin[c] deacylase : h2o + sphmyln_hsSphingolipid --> RtotalMetabolism + spc_hs SPHS1Pte 0 1 1 0 9.09 9.09 9.0903 sphingosine-1-phosphatesphs1p[c] <==> transportTransport, sphs1p[e] Extracellular SPHS1Ptr 0 1 1 0 37.31 37.31 37.309 sphingosine-1-phosphatesphs1p[c] <==> transportTransport, sphs1p[r] ER TMDPP 0 1.3 1.3 0 27.65 27.65 21.268 [c] : pi + thymdPyrimidine <==> 2dr1p Catabolism + thym TMDS 0 1.3 1.3 0 27.65 27.65 21.268 [c] : dump + mlthfNucleotides --> dhf + dtmp TYMSFt 0 1 1 0 2 2 2 Tyramine O-sulfatetymsf[c] transport --> tymsf[e]Transport, (diffusion) Extracellular TYMSULT 0 1 1 0 2 2 2 Tyramine Sulfotransferase[c] : paps + tymTyrosine --> h + papmetabolism + tymsf TYRCBOX 0 1 1 0 2 2 2 L-Tyrosine carboxy-[c] : h + tyr-L -->Tyrosine co2 + tymmetabolism TYROXDAc 0 1 1 0 2 2 2 Tyramine:oxygen[c] : oxidoreductase(deaminating)(flavin-containing)h2o + o2 +Tyrosine tym --> metabolism4hoxpacd + h2o2 + nh4 (cytosol) UPPN 0 1.3 1.3 0 47.17 47.17 36.287 b-ureidopropionase[c] : cala + (2) Pyrimidineh + h2o --> Catabolismala-B + co2 + nh4 URATEt 0 3.3 3.3 0 11.81 11.81 3.5795 urate export fromurate[c] cytosol --> urate[e]Transport, Extracellular URATEtx 0 3.3 3.3 0 11.81 11.81 3.5795 urate export fromurate[x] peroxisome --> urate[c]Transport, Peroxisomal URIt -0.15 1.15 1.3 -18.9 1.15 20.03 15.404 uridine facilateduri[e] transport <==> uri[c] inTransport, cytosol Extracellular VALtec 0 1 1 ##### 0.73 5E+05 500001 L-valine transportval-L[e] via diffusion<==> val-L[c]Transport, (extracellular Extracellular to cytosol) XANtx 0 0.15 0.15 0 11.81 11.81 78.75 diffusionxan[c] in -->peroxisome xan[x]Transport, Peroxisomal XAO2x 0 3.3 3.3 0 11.81 11.81 3.5795 [x] : h2o + hxanPurine + o2 -->Catabolism h2o2 + xan XAOx 0 3.3 3.3 0 11.81 11.81 3.5795 xanthine oxidase,peroxisomal[x] : h2o + o2 + xan --> Catabolism h2o2 + urate

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