Final Name 2020 Annual Meeting Program
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COVID-19 and Neonatal Respiratory Care: Current Evidence and Practical Approach
Published online: 2020-05-02 780 Review Article COVID-19 and Neonatal Respiratory Care: Current Evidence and Practical Approach Wissam Shalish, MD1 Satyanarayana Lakshminrusimha, MD2 Paolo Manzoni, MD3 Martin Keszler, MD4 Guilherme M. Sant’Anna, MD, PhD, FRCPC1 1 Neonatal Division, Department of Pediatrics, McGill University Address for correspondence Guilherme M. Sant’Anna, MD, PhD, Health Center, Montreal, Quebec, Canada FRCPC, Neonatal Division, Department of Pediatrics, McGill University 2 Department of Pediatrics, UC Davis, Sacramento, California Health Center, 1001 Décarie Boulevard, Room 05.2711, 3 Department of Pediatrics and Neonatology, University Hospital Montreal H4A 3J1, Canada (e-mail: [email protected]). Degli Infermi, Biella, Italy 4 Department of Pediatrics, Women and Infants Hospital, Brown University, Providence, Rhode Island Am J Perinatol 2020;37:780–791. Abstract The novel coronavirus disease 2019 (COVID-19) pandemic has urged the development and implementation of guidelines and protocols on diagnosis, management, infection control strategies, and discharge planning. However, very little is currently known about neonatal COVID-19 and severe acute respiratory syndrome–coronavirus-2 (SARS-CoV-2) infections. Thus, many questions arise with regard to respiratory care after birth, necessary protection to health care workers (HCW) in the delivery room and neonatal intensive care unit (NICU), and safety of bag and mask ventilation, noninvasive respiratory support, deep suctioning, endotracheal intubation, and mechanical ventilation. Indeed, these questions have created tremendous confusion amongst neonatal HCW. In this manuscript, we comprehensively reviewed the current evidence regarding COVID-19 perinatal transmission, respiratory outcomes of neonates born to mothers with COVID-19 and infants with documented SARS- CoV-2 infection, and the evidence for using different respiratory support modalities and aerosol-generating procedures in this specific population. -
Report of the International Narcotics Control Board for 2020 (E/INCB/2020/1) Is Supplemented by the Following Reports
INTERNATIONAL NARCOTICS CONTROL BOARD Report 2020 EMBARGO Observe release date: Not to be published or broadcast before Thursday 25 March 2021, at 1100 hours (CET) UNITED NATIONS CAUTION Reports published by the International Narcotics Control Board for 2020 TheReport of the International Narcotics Control Board for 2020 (E/INCB/2020/1) is supplemented by the following reports: Celebrating 60 Years of the Single Convention on Narcotic Drugs of 1961 and 50 Years of the Convention on Psychotropic Substances of 1971 (E/INCB/2020/1/Supp.1) Narcotic Drugs: Estimated World Requirements for 2021 — Statistics for 2019 (E/INCB/2020/2) Psychotropic Substances: Statistics for 2019 — Assessments of Annual Medical and Scientific Requirements for Substances in Schedules II, III and IV of the Convention on Psychotropic Sub- stances of 1971 (E/INCB/2020/3) Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psycho tropic Substances: Report of the International Narcotics Control Board for 2020 on the Implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 (E/INCB/2020/4) The updated lists of substances under international control, comprising narcotic drugs, psycho tropic substances and substances frequently used in the illicit manufacture of narcotic drugs and psychotropic substances, are contained in the latest editions of the annexes to the statistical forms (“Yellow List”, “Green List” and “Red List”), which are also issued by the Board. Contacting the International Narcotics Control Board The secretariat of the Board may be reached at the following address: Vienna International Centre Room E1339 P.O. -
COVID-19 and Total Laryngectomy—A Report of Two Cases
AORXXX10.1177/0003489420935500Annals of Otology, Rhinology & LaryngologyPaderno et al 935500case-report2020 Case Report Annals of Otology, Rhinology & Laryngology 1 –4 COVID-19 and Total Laryngectomy © The Author(s) 2020 Article reuse guidelines: sagepub.com/journals-permissions —A Report of Two Cases DOI:https://doi.org/10.1177/0003489420935500 10.1177/0003489420935500 journals.sagepub.com/home/aor Alberto Paderno, MD1 , Milena Fior, MD1, Giulia Berretti, MD1, Francesca Del Bon, MD1, Alberto Schreiber, MD, PhD1, Alberto Grammatica, MD1, Davide Mattavelli, MD1, and Alberto Deganello, MD, PhD1 Abstract Objective: To date, no cases have been reported on the effects of COVID-19 in laryngectomees. Case Presentation: We herein presented two clinical cases of laryngectomized patients affected by COVID-19, detailing their clinical course and complications. Discussion: In our experience, permanent tracheostomy did not significantly affect the choice of treatment. However, dedicated devices and repeated tracheal toilettes may be needed to deal with oxygen-therapy-related tracheal crusting. Conclusion: In conclusion, laryngectomees should be considered a vulnerable population that may be at risk for worse outcomes of COVID-19 due to anatomical changes in their airways. The role of the ENT specialist is to guide airway management and inform the support-staff regarding specific needs of these patients. Keywords COVID-19, coronavirus, SARS-CoV-2, laryngectomy, management Introduction At admission (March 9, 2020), the most relevant clinical findings included severe oxygen desaturation (76%), tachy- To date, the effects of COVID-19 on laryngectomized pnea, cyanosis, lymphocytopenia, and C reactive protein patients is unknown, with no cases reported so far. After (CRP; 185 mg/L). -
Report on a Novel Emerging Class of Highly Potent Benzimidazole NPS Opioids: Chemical and in Vitro Functional Characterization of Isotonitazene
Received: 29 August 2019 Revised: 12 November 2019 Accepted: 13 November 2019 DOI: 10.1002/dta.2738 RESEARCH ARTICLE Report on a novel emerging class of highly potent benzimidazole NPS opioids: Chemical and in vitro functional characterization of isotonitazene Peter Blanckaert1† | Annelies Cannaert2† | Katleen Van Uytfanghe2 | Fabian Hulpia3 | Eric Deconinck4 | Serge Van Calenbergh3 | Christophe Stove2 1Scientific Direction Epidemiology and Public Health, Section Lifestyle and Chronic Diseases, Abstract Belgian Early Warning System Drugs This paper reports on the identification and full chemical characterization of (BEWSD), Sciensano, Brussels, Belgium isotonitazene (N,N-diethyl-2-[5-nitro-2-({4-[(propan-2-yl)oxy]phenyl}methyl)-1H-ben- 2Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical zimidazol-1-yl]ethan-1-amine), a potent NPS opioid and the first member of the Sciences, Ghent University, Ghent, Belgium benzimidazole class of compounds to be available on online markets. Interestingly, 3Laboratory for Medicinal Chemistry, Department of Pharmaceutics, Faculty of this compound was sold under the name etonitazene, a structural analog. Identifica- Pharmaceutical Sciences, Ghent University, tion of isotonitazene was performed by gas chromatography mass spectrometry Ghent, Belgium (GC–MS) and liquid chromatography time-of-flight mass spectrometry (LC-QTOF- 4Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health MS), the latter identifying an exact-mass m/z value of 411.2398. All chromatographic Products, Sciensano, Brussels, Belgium data indicated the presence of a single, highly pure compound. Confirmation of the 1 13 Correspondence specific benzimidazole regio-isomer was performed using H and C NMR spectros- copy, after which the chemical characterization was finalized by recording Fourier- Christophe Stove, Laboratory of Toxicology, Department of Bioanalysis, Faculty of transform (FT-IR) spectra. -
Accepted Manuscript Version
Research Archive Citation for published version: Kim Akass, and Janet McCabe, ‘HBO and the Aristocracy of Contemporary TV Culture: affiliations and legitimatising television culture, post-2007’, Mise au Point, Vol. 10, 2018. DOI: Link to published article in journal's website Document Version: This is the Accepted Manuscript version. The version in the University of Hertfordshire Research Archive may differ from the final published version. Copyright and Reuse: This manuscript version is made available under the terms of the Creative Commons Attribution-NonCommercial- NoDerivatives License CC BY NC-ND 4.0 ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. Enquiries If you believe this document infringes copyright, please contact Research & Scholarly Communications at [email protected] 1 HBO and the Aristocracy of TV Culture : affiliations and legitimatising television culture, post-2007 Kim Akass and Janet McCabe In its institutional pledge, as Jeff Bewkes, former-CEO of HBO put it, to ‘produce bold, really distinctive television’ (quoted in LaBarre 90), the premiere US, pay- TV cable company HBO has done more than most to define what ‘original programming’ might mean and look like in the contemporary TV age of international television flow, global media trends and filiations. In this article we will explore how HBO came to legitimatise a contemporary television culture through producing distinct divisions ad infinitum, framed as being rooted outside mainstream commercial television production. In creating incessant divisions in genre, authorship and aesthetics, HBO incorporates artistic norms and principles of evaluation and puts them into circulation as a succession of oppositions— oppositions that we will explore throughout this paper. -
Netflix and the Development of the Internet Television Network
Syracuse University SURFACE Dissertations - ALL SURFACE May 2016 Netflix and the Development of the Internet Television Network Laura Osur Syracuse University Follow this and additional works at: https://surface.syr.edu/etd Part of the Social and Behavioral Sciences Commons Recommended Citation Osur, Laura, "Netflix and the Development of the Internet Television Network" (2016). Dissertations - ALL. 448. https://surface.syr.edu/etd/448 This Dissertation is brought to you for free and open access by the SURFACE at SURFACE. It has been accepted for inclusion in Dissertations - ALL by an authorized administrator of SURFACE. For more information, please contact [email protected]. Abstract When Netflix launched in April 1998, Internet video was in its infancy. Eighteen years later, Netflix has developed into the first truly global Internet TV network. Many books have been written about the five broadcast networks – NBC, CBS, ABC, Fox, and the CW – and many about the major cable networks – HBO, CNN, MTV, Nickelodeon, just to name a few – and this is the fitting time to undertake a detailed analysis of how Netflix, as the preeminent Internet TV networks, has come to be. This book, then, combines historical, industrial, and textual analysis to investigate, contextualize, and historicize Netflix's development as an Internet TV network. The book is split into four chapters. The first explores the ways in which Netflix's development during its early years a DVD-by-mail company – 1998-2007, a period I am calling "Netflix as Rental Company" – lay the foundations for the company's future iterations and successes. During this period, Netflix adapted DVD distribution to the Internet, revolutionizing the way viewers receive, watch, and choose content, and built a brand reputation on consumer-centric innovation. -
NAME E-Book 2012
THE HISTORY OF THE NAME National Association of Medical Examiners Past Presidents History eBook 2012 EDITION Published by the Past Presidents Committee on the Occasion of the 46th Annual Meeting at Baltimore, Maryland Preface to the 2012 NAME History eBook The Past Presidents Committee has been continuing its effort of compiling the NAME history for the occasion of the 2016 NAME Meeting’s 50th Golden Anniversa- ry Meeting. The Committee began collecting historical materials and now solicits the histories of individual NAME Members in the format of a guided autobiography, i.e. memoir. Seventeen past presidents have already contributed their memoirs, which were publish in a eBook in 2011. We continued the same guided autobiography format for compiling historical ma- terial, and now have additional memoirs to add also. This year, the book will be combined with the 2011 material, and some previous chapters have been updated. The project is now extended to all the NAME members, who wish to contribute their memoirs. The standard procedure is also to submit your portrait with your historical/ memoir material. Some of the memoirs are very short, and contains a minimum information, however the editorial team decided to include it in the 2012 edition, since it can be updated at any time. The 2012 edition Section I – Memoir Series Section II - ME History Series – individual medical examiner or state wide system history Presented in an alphabetic order of the name state Section III – Dedication Series - NAME member written material dedicating anoth- er member’s contributions and pioneer work, or newspaper articles on or dedicated to a NAME member Plan for 2013 edition The Committee is planning to solicit material for the chapters dedicated to specifi- cally designated subjects, such as Women in the NAME, Standard, Inspection and Accreditation Program. -
Interrogations and Confessions
CHAPTER 16 INTERROGATIONS AND CONFESSIONS Did the police constitutionally obtain the defendant’s confession to murder? Dr. Jeffrey Metzner, a psychiatrist employed by the state hospital, testified that respondent was suffering from chronic schizophrenia and was in a psychotic state at least as of August 17, 1983, the day before he confessed. Metzner’s interviewsdistribute with respondent revealed that respondent was following the “voice of God.” This voice instructed respondent to withdraw money from the bank, to buy an airplane ticket, and to fly from Boston to Denver. When respondent arrived from Boston, God’s voice became stronger and told respondent either to confess to the killing or to commit suicide. Reluctantly following the command of the voices, respondent approached Officeror [Patrick] Anderson and confessed. Dr. Metzner testified that, in his expert opinion, respondent was experiencing “command hallucinations.” This condition interfered with respondent’s “volitional abilities; that is, his ability to make free and rational choices.” (Colorado v. Connelly, 479 U.S. 157 [1986]) CHAPTER OUTLINE post, Introduction Case Analysis Due Process Chapter Summary The Right Against Self-Incrimination Chapter Review Questions Miranda v. Arizona copy, Legal Terminology Sixth Amendment Right to Counsel: Police Interrogations not DoTEST YOUR KNOWLEDGE 1. Do you know the role of confessions in the criminal investigation process, the potential challenges and problems presented by confessions, and the explanations for false confessions? 2. Are you able to discuss the protections provided by the Fifth Amendment right against self-incrimination and what is protected by the Fifth Amendment and what is not protected? 3. Can you explain how Miranda v. -
View Entire Issue As
Volume 15 Issue 14 September 11 - 24, 2008 The Milwau ee LGBT Film/Video Festival Final Days • Complete Guide Inside iR i t Orf LIM nI ' i FALL ARTS PREVIEW WRAP UP LOGO Star Jennie McNulty Shines Bright in Superior Plus lots more in entertainment inside! WHY BE SHY? GET TESTED for HIV, at BESTD Clinic. It's free and it's fast, with no names and no needles.We also provide free STD testing, exams, and treatment. Staffed totally by volunteers and supported by donations, BESTD has been doing HIV outreach since 1987. We're open: Mondays 6 PM-8:30 PM: Free HIV & STD testing Tuesdays 6 PM-8:30 PM: All of the above plus STD exams and treatment Some services only available for men; visit our web site for details. BESTD cum(' Brady East STD Clinic 1240 E. Brady Street Milwaukee, WI 53202 414-272-2144 www.bestd.org DIES "Legal couple status may support a relationship," LESBIAN RIGHTS PIONEER DEL MARTIN researcher Robert-Jay Green said in a statement an- Lesbian Rights Pioneer Del Mar- things. nouncing the findings. tin Dies "I also never imagined there Surprise! Log Cabin Republicans Endorse Mc- San Francisco - Just two months would be a day that we would ac- Cain-Palhi Ticket: The Log Cabin Republicans after achieving a life-long dream, tually be able to get married," Lyon (LCR), who refused to endorse George W. Bush for the legal marriage to her partner of wrote. "I am devastated, but I take reelection in 2004, announced their endorsement of 55 years, lesbian rights pioneer Del some solace in knowing we were Senator John McCain for President of the United Martin - whose trailblazing activism able to enjoy the ultimate rite of States on September 2: LCR's board of directors spanned more than a half century - love and commitment before she voted 12-2 to endorse both McCain and Alaska Gov- died August 27 at a local hospice. -
Benzimidazole-Opioids June 2021
Drug Enforcement Administration Diversion Control Division Drug & Chemical Evaluation Section Benzimidazole-Opioids June 2021 Introduction: metonitazene, metodesnitazene, and protonitazene involved interaction with β-arrestin-2. Mu-opioid receptor and β-arrestin-2 Recently, several synthetic substances of benzimidazole interaction has been implicated in adverse health effects of many structural class are being trafficked and abused for their opioid- opioid analgesics. It is well established that mu-opioid receptor like effects. In the late 1950s, the pharmaceutical research agonists have a high potential for addiction and can produce dose- laboratories of the Swiss chemical company CIBA dependent respiratory depression and arrest. Abuse of these Aktiengesellschaft synthesized numerous benzimidazole- benzimidazole-opioids has led to their positive identification in opioids to include butonitazene, etodesnitazene, flunitazene, several toxicological cases in the United States. Specifically, metonitazene, metodesnitazene, and protonitazene. Since metonitazene has been identified in twenty post-mortem cases. 2019, the abuse of benzimidazole-opioids as evidenced by their identification in toxicology cases, similar to other synthetic opioids, has resulted in adverse health effects including deaths. User Population: As the United States continues to experience an unprecedented The population likely to abuse benzimidazole-opioids appears to be epidemic of opioid misuse and abuse, the continued evolution the same as those abusing prescription opioid analgesics, heroin, and increased trafficking and popularity of new and deadly and other synthetic opioid substances. This is evidenced by the synthetic opioids including benzimidazole-opioids with no types of other drugs co-identified in isotonitazene seizures and in approved medical use are of public health concern. fatal overdose cases. Toxicology analyses co-identified some of these benzimidazole-opioids with other opioids, stimulants, and Chemistry: benzodiazepines. -
Direct Analysis of Opioids and Metabolites in Oral Fluid by Mixed-Mode Μelution SPE Combined with UPLC-MS/MS for Forensic Toxicology Jonathan P
Direct Analysis of Opioids and Metabolites in Oral Fluid by Mixed-mode µElution SPE Combined with UPLC-MS/MS for Forensic Toxicology Jonathan P. Danaceau, Erin E. Chambers, and Kenneth J. Fountain Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION ■■ Analysis of all metabolites without The analysis of natural and synthetic opioid drugs continues to be an important enzymatic hydrolysis aspect of forensic toxicology. In the past, analyses were typically conducted by GC/MS after first subjecting the samples to acid or enzymatic hydrolysis to ■■ Comprehensive panel of 26 opiate 1 and opioid analgesic compounds liberate glucuronide metabolites. With the advent of LC-MS/MS techniques, glucuronide metabolites can now be analyzed directly.2-5 Direct analyses of ■■ Rapid and simple sample preparation these metabolites can eliminate the risk of false negatives due to incomplete in oral fluid hydrolysis, as enzymatic efficiency can vary greatly depending upon the enzyme ■■ Linear, accurate and precise responses used and the drug substrate analyzed.6 for all analytes and metabolites One particular sample matrix that has become increasingly popular recently is oral fluid. Unlike urine, oral fluid can be more indicative of current impairment or intoxication. Collection can also be easily accomplished without the privacy issues and adulteration possibilities associated with urine collection. Oral fluid also has similar advantages over blood as a matrix. Once again, collection is much easier, since it is non-invasive and there is no need for specialized training. This application highlights a method for the analysis of 26 opioid drugs and metabolites by mixed-mode SPE followed by UPLC®-MS/MS.