Contact Dermatitis/Eczema
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Contact Vitiligo Following Allergic Contact Dermatitis *Ricardo Ruiz-Villaverde, Francisco J Navarro-Triviño
SUBMITTED 19 JAN 21 REVISION REQ. 17 MAR 21; REVISION 5 APR 21 ACCEPTED 21 APR 21 ONLINE-FIRST: MAY 2021 DOI: https://doi.org/10.18295/squmj.5.2021.078 Contact Vitiligo Following Allergic Contact Dermatitis *Ricardo Ruiz-Villaverde, Francisco J Navarro-Triviño Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain *Corresponding Author’s e-mail: [email protected] Introduction A 45-year-old man, construction worker, with no personal history of psoriasis, atopic dermatitis, and vitiligo, was referred to our Contact Eczema Department with a chronic hand eczema and skin depigmentation over a period of 12 months. Skin depigmentation appeared few months later regarding the primary eczema. The patient reported the use of rubber gloves for many years. He had noticed itching and mild erythema over both hands. Currently, he wears nitrile gloves at work. Physical examination showed symmetric erythematous-squamous, hyperkeratotic and fissured plaques on both hands (Fig. 1A), and ventral aspect of wrists (Fig. 1B). Skin depigmentation areas showed irregular edges (Fig. 1C). Wood´s lamp examination accentuated the depigmentation areas overlap the eczema (Fig. 2A-B), without vitiligo pattern. No other anatomical sites were involved. Blood test showed no significant alterations, including data from autoimmune thyroiditis, celiac disease, and pernicious anaemia. Patch tests were performed with the European Comprehensive Baseline Series (Chemotechnique Diagnostics, Vellinge, Sweden), rubber additives series (Chemotechnique Diagnostics), and hydroquinone monobenzylether 1% pet (Shoe series, Chemotechnique Diagnosis). The results were interpreted according to the criteria of the International Contact Dermatitis Research Group. Patch tests were read on day (D) 2 and D4. -
Seborrheic Dermatitis: an Overview ROBERT A
Seborrheic Dermatitis: An Overview ROBERT A. SCHWARTZ, M.D., M.P.H., CHRISTOPHER A. JANUSZ, M.D., and CAMILA K. JANNIGER, M.D. University of Medicine and Dentistry at New Jersey-New Jersey Medical School, Newark, New Jersey Seborrheic dermatitis affects the scalp, central face, and anterior chest. In adolescents and adults, it often presents as scalp scaling (dandruff). Seborrheic dermatitis also may cause mild to marked erythema of the nasolabial fold, often with scaling. Stress can cause flare-ups. The scales are greasy, not dry, as commonly thought. An uncommon generalized form in infants may be linked to immunodeficiencies. Topical therapy primarily consists of antifungal agents and low-potency steroids. New topical calcineurin inhibitors (immunomodulators) sometimes are administered. (Am Fam Physician 2006;74:125-30. Copyright © 2006 American Academy of Family Physicians.) eborrheic dermatitis can affect patients levels, fungal infections, nutritional deficits, from infancy to old age.1-3 The con- neurogenic factors) are associated with the dition most commonly occurs in condition. The possible hormonal link may infants within the first three months explain why the condition appears in infancy, S of life and in adults at 30 to 60 years of age. In disappears spontaneously, then reappears adolescents and adults, it usually presents as more prominently after puberty. A more scalp scaling (dandruff) or as mild to marked causal link seems to exist between seborrheic erythema of the nasolabial fold during times dermatitis and the proliferation of Malassezia of stress or sleep deprivation. The latter type species (e.g., Malassezia furfur, Malassezia tends to affect men more often than women ovalis) found in normal dimorphic human and often is precipitated by emotional stress. -
Genital Lichen Simplex Chronicus (Eczema, Neurodermatitis, Dermatitis) !
Libby Edwards, MD Genital Lichen Simplex Chronicus (eczema, neurodermatitis, dermatitis) ! Lichen simplex chronicus (LSC), or eczema, is a common skin condition that is very itchy. Although not dangerous in any way, both the itching, and the pain from rubbing and scratching, can be miserable. Eczema/LSC of the genital area most often affects the scrotum of men, the vulva of women, or the rectal skin of both. Many people with eczema/LSC have had sensitive skin or eczema/LSC on other areas of the skin at some point, and many have a tendency towards allergies, especially hay fever or asthma. ! The skin usually appears red or dark, and thick from rubbing and scratching, sometimes with sores from scratching. ! The cause of eczema/LSC is not entirely clear. However, eczema/LSC starts with irritation that triggers itching. Often, at the office visit with the health care provider, the original infection or other initial cause of irritation is no longer present. Common triggers include a yeast or fungus infection, an irritating medication, moisturizer or lubricant, a wet bathing suit, anxiety or depression, over-washing, panty liners, sweat, heat, urine, a contraceptive jelly, an irritating condom, or any other activity or substance that can irritate the skin and start the itching. ! Although rubbing and scratching often feel good at first, rubbing irritates the skin and ultimately makes itching even worse, so that there is more scratching, then more itching, then more scratching. This is called the “itch-scratch cycle.” Treatment is very effective and requires clearing any infection and avoiding irritants as well as using a strong cortisone. -
Scalp Eczema Factsheet the Scalp Is an Area of the Body That Can Be Affected by Several Types of Eczema
12 Scalp eczema factsheet The scalp is an area of the body that can be affected by several types of eczema. The scalp may be dry, itchy and scaly in a chronic phase and inflamed (red), weepy and painful in an acute (eczema flare) phase. Aside from eczema, there are a number of reasons why the scalp can become dry and itchy (e.g. psoriasis, fungal infection, ringworm, head lice etc.), so it is wise to get a firm diagnosis if there is uncertainty. Types of eczema • Hair clips and headgear – especially those containing that affect the scalp rubber or nickel. Seborrhoeic eczema (dermatitis) is one of the most See the NES booklet on Contact Dermatitis for more common types of eczema seen on the scalp and hairline. details. It can affect babies (cradle cap), children and adults. The Irritant contact dermatitis is a type of eczema that skin appears red and scaly and there is often dandruff as occurs when the skin’s surface is irritated by a substance well, which can vary in severity. There may also be a rash that causes the skin to become dry, red and itchy. on other parts of the face, such as around the eyebrows, For example, shampoos, mousses, hair gels, hair spray, eyelids and sides of the nose. Seborrhoeic eczema can perm solution and fragrance can all cause irritant contact become infected. See the NES factsheets on Adult dermatitis. See the NES booklet on Contact Dermatitis for Seborrhoeic Dermatitis and Infantile Seborrhoeic more details. Dermatitis and Cradle Cap for more details. -
Pompholyx Factsheet Pompholyx Eczema (Also Known As Dyshidrotic Eczema/Dermatitis) Is a Type of Eczema That Usually Affects the Hands and Feet
12 Pompholyx factsheet Pompholyx eczema (also known as dyshidrotic eczema/dermatitis) is a type of eczema that usually affects the hands and feet. In most cases, pompholyx eczema involves the development of intensely itchy, watery blisters, mostly affecting the sides of the fingers, the palms of the hands and soles of the feet. Some people have pompholyx eczema on their hands and/or feet with other types of eczema elsewhere on the body. This condition can occur at any age but is usually seen in adults under 40, and is more common in women. The skin is initially very itchy with a burning sensation of heat and prickling in the palms and/or soles. Then comes a sudden crop of small blisters (vesicles), which turn into bigger weepy blisters, which can become infected, causing redness, pain, swelling and pustules. There is often subsequent peeling as the skin dries out, and then the skin can become red and dry with painful cracks (skin fissures). Pompholyx eczema can also affect the nail folds and skin around the nails, causing swelling (paronychia). What causes it? A reaction could be the result of contact with potential irritants such as soap, detergents, solvents, acids/alkalis, The exact causes of pompholyx eczema are not known, chemicals and soil, causing irritant contact dermatitis. Or although it is thought that factors such as stress, there could be an allergic reaction to a substance that is sensitivity to metal compounds (such as nickel, cobalt or not commonly regarded as an irritant, such as rubber or chromate), heat and sweating can aggravate this nickel, causing allergic contact dermatitis. -
Hand Dermatitis – Contact Dermatitis David E
3/2/2021 Hand Dermatitis – Contact Dermatitis David E. Cohen, M.D., M.P.H. Charles and Dorothea Harris Professor and Vice Chairman for Clinical Affairs Director of Allergic, Occupational and Environmental Dermatology New York University School of Medicine Department of Dermatology IEC 2021 Hand Eczema Virtual Symposium 1 •David E Cohen has declared the following financial interests: . Consultant and Honorarium: . Ferndale Laboratories, . Asana . Medimetriks . Leo . UCB . Cutanea [past] . Ferrer [past] . Celgene [past] . Novartis . Dermavant . FSJ . FIDE. (FIDE receives industry sponsorship from AbbVie, Almirall, Amgen, Bausch and Lomb, Bristol- Myers Squibb, Celgene Dermavant, Dermira, Janssen, Kyowa Hakko Kirin, LEO, Lilly, Novartis, Ortho Dermatologics, Pfizer, Sanofi Genzyme, Sun Pharma, UCB, Valeant) . Cosmetic Ingredient Review (CIR) •Stock or stock options: Dermira [past], Medimetriks [past], Brickell Biotech, Kadmon, Evommune, Timber •Board of Directors: Kadmon, Timber, Evommune, [Dermira-Past] I will discuss non-FDA approved patch test allergens, and emerging therapies 2 Hand Dermatitis • General population prevalence is 5% to 10% . Health care workers, exposed to wet work, frequent hand washing, and AD. Atopic dermatitis (AD) is recognized as the top risk factor Causes: • Exogenous: Irritant and Allergic Contact Dermatitis • Endogenous: Psoriasis, Dyshidrosis, Atopic Dermatitis, Nummular • ID • HYBRID • Spectrum for eczematous disease is vesicular and eroded to hyperkeratotic and fissured • Hand Psoriasis may have higher rates of allergic contact dermatitis. Int J Occup Environ Health. 2018 Jan 23:1-10. Ther Clin Risk Manag. 2020 Dec 31;16:1319-1332. doi: Contact Dermatitis. 2014 Jan;70(1):44-55. 10.2147/TCRM.S292504.eCollection 2020 Indian Dermatol Online J. 2012 Sep;3(3):177-81. -
Atopic Dermatitis 101 for Adults
TRIGGER TRACKER Atopic Dermatitis 101 for Adults WHAT IS ATOPIC DERMATITIS? IS THERE A CURE? Atopic dermatitis (AD) is the most common type There is no cure for of eczema. It often appears as a red, itchy rash or atopic dermatitis yet, dry, scaly patches on the skin. AD usually begins but there are treatments in infancy or childhood but can develop at any available and more are on the way. point in a person’s lifetime. It commonly shows up on the face, inside of the elbows or behind the WHAT ARE MY TREATMENT OPTIONS? knees, but it can appear anywhere on the body. It is important to have a regular schedule with AD care that includes bathing with a gentle IS IT CONTAGIOUS ? cleanser and moisturizing to lock water into the You can’t catch atopic dermatitis or spread it to skin and repair the skin barrier. Moisturized skin others. helps control flares by combating dryness and keeping out irritants and allergens. WHAT CAUSED IT? Depending on severity of symptoms and age, AD While the exact cause is unknown, researchers do treatments include lifestyle changes, over-the- know that people develop atopic dermatitis counter (OTC) and natural remedies, prescription because of a combination of genes and a trigger. topical medications, which are applied to the People with AD tend to have an over-reactive immune system that when triggered by skin; biologics, given by injection; something outside or inside the body, responds immunosuppressants, usually taken by mouth in by producing inflammation. It is this inflammation the form of a pill; and phototherapy, a form of that causes red, itchy and painful skin symptoms. -
Compensation for Occupational Skin Diseases
ORIGINAL ARTICLE http://dx.doi.org/10.3346/jkms.2014.29.S.S52 • J Korean Med Sci 2014; 29: S52-58 Compensation for Occupational Skin Diseases Han-Soo Song1 and Hyun-chul Ryou2 The Korean list of occupational skin diseases was amended in July 2013. The past list was constructed according to the causative agent and the target organ, and the items of that 1 Department of Occupational and Environmental list had not been reviewed for a long period. The revised list was reconstructed to include Medicine, College of Medicine, Chosun University, Gwangju; 2Teo Center of Occupational and diseases classified by the International Classification of Diseases (10th version). Therefore, Environmental Medicine, Changwon, Korea the items of compensable occupational skin diseases in the amended list in Korea comprise contact dermatitis; chemical burns; Stevens-Johnson syndrome; tar-related skin diseases; Received: 19 December 2013 infectious skin diseases; skin injury-induced cellulitis; and skin conditions resulting from Accepted: 2 May 2014 physical factors such as heat, cold, sun exposure, and ionized radiation. This list will be Address for Correspondence: more practical and convenient for physicians and workers because it follows a disease- Han-Soo Song, MD based approach. The revised list is in accordance with the International Labor Organization Department of Occupational and Environmental Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, list and is refined according to Korean worker’s compensation and the actual occurrence of Gwangju 501-717, Korea occupational skin diseases. However, this revised list does not perfectly reflect the actual Tel: +82.62-220-3689, Fax: +82.62-443-5035 E-mail: [email protected] status of skin diseases because of the few cases of occupational skin diseases, incomplete statistics of skin diseases, and insufficient scientific evidence. -
Lichen Simplex Chronicus
LICHEN SIMPLEX CHRONICUS http://www.aocd.org Lichen simplex chronicus is a localized form of lichenified (thickened, inflamed) atopic dermatitis or eczema that occurs in well defined plaques. It is the result of ongoing, chronic rubbing and scratching of the skin in localized areas. It is generally seen in patients greater than 20 years of age and is more frequent in women. Emotional stress can play a part in the course of this skin disease. There is mainly one symptom: itching. The rubbing and scratching that occurs in response to the itch can become automatic and even unconscious making it very difficult to treat. It can be magnified by seeming innocuous stimuli such as putting on clothes, or clothes rubbing the skin which makes the skin warmer resulting in increased itch sensation. The lesions themselves are generally very well defined areas of thickened, erythematous, raised area of skin. Frequently they are linear, oval or round in shape. Sites of predilection include the back of the neck, ankles, lower legs, upper thighs, forearms and the genital areas. They can be single lesions or multiple. This can be a very difficult condition to treat much less resolve. It is of utmost importance that the scratching and rubbing of the skin must stop. Treatment is usually initiated with topical corticosteroids for larger areas and intralesional steroids might also be considered for small lesion(s). If the patient simply cannot keep from rubbing the area an occlusive dressing might be considered to keep the skin protected from probing fingers. Since this is not a histamine driven itch phenomena oral antihistamines are generally of little use in these cases. -
Allergic Contact Rashes Allergic Contact Dermatitis Is Caused by the Body’S Reaction to Something That It Comes in Direct Skin Contact with It
1812 W. Burbank Blvd. #1046 | Burbank, CA 91506 Tel: (877) 822-2223 | Fax: (323) 935-8804 DermLA.com Allergic Contact Rashes Allergic contact dermatitis is caused by the body’s reaction to something that it comes in direct skin contact with it. Many different substances can cause allergic contact dermatitis, and we call these substances “allergens”. Usually this substance causes no trouble for most people, and may not even be noticed the first time the person is exposed. But once the skin becomes sensitive or allergic to the substance, any exposure will produce a rash. The rash usually doesn’t start until a day or two later, but can start a soon as hours or as late as weeks. You can become allergic or sensitive to anything at anytime, even a product you have used for years. Allergic contact dermatitis is not usually caused by things like acid, alkali, solvent, strong soap or detergent. These harsh compounds, which can produce a reaction on anyone’s skin, are known as “irritants.” Although some chemicals are both irritants and allergens, allergic contact dermatitis results from brief contact with substances that don’t usually provoke a reaction in most people. The dermatitis usually shows redness, swelling and water blisters, from tiny to large. The blisters may break,forming crusts and scales. Untreated, the skin may darken and become leathery and cracked. Allergic contact dermatitis can be difficult to distinguish from other rashes, especially after it been present for a while. The dermatologist and patient will discuss the materials that touch the person’s skin at work and home, and try to identify the allergen. -
Decreased Prevalence of Atopy in Paediatric Patients with Familial
187 EXTENDED REPORT Ann Rheum Dis: first published as 10.1136/ard.2003.007013 on 13 January 2004. Downloaded from Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever C Sackesen, A Bakkaloglu, B E Sekerel, F Ozaltin, N Besbas, E Yilmaz, G Adalioglu, S Ozen ............................................................................................................................... Ann Rheum Dis 2004;63:187–190. doi: 10.1136/ard.2003.007013 Background: A number of inflammatory diseases, including familial Mediterranean fever (FMF), have been shown to be driven by a strongly dominated Th1 response, whereas the pathogenesis of atopic diseases is associated with a Th2 response. Objective: Because dominance of interferon gamma has the potential of inhibiting Th2 type responses— that is, development of allergic disorders, to investigate whether FMF, or mutations of the MEFV gene, See end of article for have an effect on allergic diseases and atopy that are associated with an increased Th2 activity. authors’ affiliations Method: Sixty children with FMF were questioned about allergic diseases such as asthma, allergic rhinitis, ....................... and atopic dermatitis, as were first degree relatives, using the ISAAC Study phase II questionnaire. The Correspondence to: ISAAC Study phase II was performed in a similar ethnic group recruited from central Anatolia among Dr S Ozen, Hacettepe 3041 children. The same skin prick test panel used for the ISAAC Study was used to investigate the University Medical Faculty, presence of atopy in patients with FMF and included common allergens. Paediatric Nephrology Results: The prevalences of doctor diagnosed asthma, allergic rhinitis, and eczema were 3.3, 1.7, and and Rheumatic Diseases Unit, Sihhiye, 06100 3.3%, respectively, in children with FMF, whereas the corresponding prevalences in the ISAAC study were Ankara, Turkey; 6.9, 8.2, and 2.2%, respectively. -
The Dyshidrotic Eczema Area and Severity Index – a Score Developed for the Assessment of Dyshidrotic Eczema
Clinical and Laboratory Investigations Dermatology 1999;198:265–269 Received: September 29, 1998 Accepted: February 19, 1999 The Dyshidrotic Eczema Area and Severity Index – A Score Developed for the Assessment of Dyshidrotic Eczema E. Vocks a S.G. Plötz b J. Ring a aDepartment of Dermatology and Allergology Biederstein, Technical University München, and bResearch Center Borstel, Center for Medicine and Bioscience, Borstel, Germany Key Words factors, such as atopic eczema, contact allergy or mycosis, Severity index • Dyshidrotic eczema • Pompholyx • but many cases are also classified as idiopathic [1–3]. As it Treatment study can be very resistant to treatment [4], studies with regard to new therapeutic modalities in dyshidrotic eczema are important. The evaluation of therapeutic effects is carried Abstract out by different methods. In most studies global assessment Background: Dyshidrotic eczema of the palms and soles methods like grading of improvement [5–8] are used. Hand is a common condition, which can be rather resistant to eczema scoring systems which are applied to eczema on the treatment. Therapy studies and their comparability are of palmar and dorsal hands are not specific for the distinct fea- clinical importance. Objective: As standardized assess- tures of dyshidrotic eczema [9]. Since the assessment meth- ment methods for the severity of this particular form of ods for dyshidrotic eczema are not standardized, therapeutic eczema are lacking, we developed a severity index for studies are not comparable and data cannot be utilized for dyshidrotic eczema. Methods: The Dyshidrotic Eczema epidemiologic purposes. As there is no specific scoring sys- Area and Severity Index (DASI) is based on the severity tem existing, we developed a severity index for dyshidrotic grade of single items – number of vesicles per square eczema on the occasion of a half-side treatment study with centimetre (V), erythema (E), desquamation (S) and itch tap water iontophoresis [10].