Drug-Induced Pruritus: a Review
Acta Derm Venereol 2009; 89: 236–244 REVIEW ARTICLE Drug-induced Pruritus: A Review Adam REICH1, Sonja STÄNDER2 and Jacek C. SZepietowsKI1,3 1Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 2Clinical Neurodermatology, Department of Dermatology, University Hospital of Münster, Germany, and 3Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland Pruritus is an unpleasant sensation that leads to scrat- polate to drugs that are prescribed mainly in outpatient ching. In addition to several diseases, the administration clinics, as only inpatients were analysed. In another of drugs may induce pruritus. It is estimated that pru- study on skin reactions due to antibacterial agents used ritus accounts for approximately 5% of all skin adverse in 13,679 patients treated by general practitioners, reactions after drug intake. However, to date there has cutaneous adverse effects were reported in 135 (1%) been no systematic review of the natural course and pos- subjects, and general pruritus accounted for 13.3% of sible underlying mechanisms of drug-induced pruritus. these reactions (4). In a recent analysis of 200 patients For example, no clear distinction has been made between with drug reactions, 12.5% showed pruritus without acute or chronic (lasting more than 6 weeks) forms of skin lesions (5). However, only a few drugs have been pruritus. This review presents a systematic categoriza- analysed more carefully in relation to pruritus, mainly tion of the different forms of drug-induced pruritus, with antimalarials, opioids, and hydroxyethyl starch (see special emphasis on a therapeutic approach to this side- below). Furthermore, analysing the available data on effect.
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