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DECEMBER 02 Nucleus DED UN 18 O 98 F yyyy N yyyy Y O T R E I T H C E N O yyyy A E S S S L T A E A C R C I yyyyN S M S E E H C C T N IO A December 2002 Vol. LXXXI, No. 4 yyyyC N • AMERI Monthly Meeting Science, Sustainability Medicinal Chemistry Symposium on Molecular Properties and Oral and the Human Prospect Bioavailability Presidential Address of P.H. Raven to the AAAS Book Review YCC Holiday Party Uncle Tungsten, by Oliver Sacks At Charley’s Saloon, December 4 2 The Nucleus December 2002 The Northeastern Section of the American Chemical Society, Inc. Contents Office: Marilou Cashman, 23 Cottage St., Natick, MA 01760. 1-800-872-2054 (Voice or FAX) or 508-653-6329. ACS Scholars _________________________________________4 e-mail: [email protected] Any Section business may be conducted YCC News ____________________________________________4 via the business office above. NESACS Homepage: Holiday Networking Social and Toy Drive; Charley’s Saloon, December 4 http://www.NESACS.org Frank R. Gorga, Webmaster Board of Directors_____________________________________ 4 Washington, D.C. ACS Hotline: Notes of the Meeting of September 12, 2002 1-800-227-5558 Officers 2002 Monthly Meeting _______________________________________5 Chair: Morton Z. Hoffman Medicinal Chemistry Symposium: Molecular Properties Influencing Oral Chemistry Department, Boston University Bioavailability in Drug Design Boston, MA 02215-2507; 617-353-2494 [email protected] Nominations __________________________________________7 Chair-Elect: John L. Neumeyer For the James Flack Norris Award for Outstanding Achievement in the Teaching Harvard Medical School/McLean Hospital of Chemistry 115 Mill St., Belmont, MA 02478; 617-855-3388 [email protected] Book Review __________________________________________7 Immediate Past Chair: Timothy B. Frigo “Uncle Tungsten: Memories of a Chemical Boyhood,” by Oliver Sacks, Advanced Magnetics, Inc. Reviewed by Dennis Sardella 61 Mooney St., Cambridge, MA 02138 617-497-2070x3007 [email protected] Science, Sustainability, and the Human Prospect _____________9 Secretary: Presidential Address of Peter H. Raven to the AAAS, February 2002 Michael Singer Sigma RBI 3 Strathmore Rd. Pictures at NESACS Events _____________________________17 Natick, MA 01760-2447 Pictures taken at recent meetings by M.Z. Hoffman 508-651-8151x291 [email protected] Cover: Treasurer: Sorry, the ACS Santa Claus wasn’t available, so the ACS Mole with James Piper Mort Hoffman, the 2002 NESACS Chair, will have to do. 19 Mill Rd., Harvard, MA 01451 (photo by M.Z. Hoffman and helper) 978-456-3155 [email protected] Deadlines: February, 2003 issue: December 13, 2002 Auditor: Anthony Rosner March, 2003 issue: January 17, 2003 Archivist: Myron Simon 20 Somerset Rd. Newton, MA 02465; 617-332-5273 [email protected] Trustees: Michael E. Strem, Joseph A. Lima, Esther A.H. Hopkins Councilors: Alternate Councilors: The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Term Ends 12/31/2002 Term Ends 12/31/2002 Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications. Mary T. Burgess Michael J. Dube Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by the Michaeline F. Chen Jean Fuller-Stanley editor six weeks before the date of issue. Doris I. Lewis Patrick M. Gordon Editor: Arno Heyn, 21 Alexander Rd., Newton, MA 02461, Julia H. Miwa John L. Neumeyer Tel: 617-969-5712, FAX: 617-527-2032; e-mail: [email protected] Term Ends 12/31/2003 Term Ends 12/31/2003 Catherine E. Costello Wallace J. Gleekman Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273 William Klemperer Arno H.A. Heyn Mukund S. Chorghade, 14 Carlson Circle, Natick, MA 01760: Dorothy J. Phillips Howard R. Mayne [email protected] Barbara G. Wood Alfred Viola Board of Publications: Patrick M. Gordon (Chair), Marietta H. Schwartz, vacant, E. Joseph Billo (Con- Term Ends 12/31/2004 Term Ends 12/31/2004 sultant) Thomas R. Gilbert Timothy B. Frigo Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622 Patricia H. Hamm Morton Z. Hoffman Michael J. Hearn Truman S. Light Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050, Arlene W. Light Donald O. Rickter Tel: 781-837-0424; FAX: 781-837-8792 Contributing Editors: Mukund Chorghade, Patricia Hamm, Features; Edward Atkinson, History of All Chairs of standing Chemistry; Dennis Sardella, Book Reviews; Marietta H. Schwartz, Software Committees, the editor Reviews; E. Joseph Billo, Puzzles. of THE NUCLEUS, and Calendar Coordinator: Donald O. Rickter, e-mail: [email protected] the Trustees of Section Funds are members of the Proofreaders: E. Joseph Billo, Donald O. Rickter, M.S. Simon Board of Directors. Any Webpage: Webmaster: Frank R. Gorga, [email protected] Councilor of the American Chemical Society Asst. Webmasters: Terry Brush, [email protected] residing within the section area is an ex officio Kurt Heinselman, [email protected] member of the Board of Directors. Copyright 2002, Northeastern Section of the American Chemical Society, Inc. The Nucleus December 2002 3 YCC News Board of Corporate Patrons YCC Holiday Networking Novartis Pharmaceutical Corp. Social and Toy Drive Directors Strem Chemicals, Inc. When: Dec. 4, 2002; 6 – 9 pm Notes of Meeting of September Corporate Sponsors 12, 2002 Where: Charley’s Saloon at 284 New- Aerodyne Research, Inc. bury St., Boston NOTE: Board Meetings are held on the Consulting Resources Corp. Come celebrate the holiday season monthly meeting day at 4:30 p.m. Sec- with younger chemists of the Boston tion members are invited to attend. Houghton Chemical Corp. area! The first 15 in attendance will Officers’ Reports: New England Biolabs, Inc. receive a free drink. Appetizers will be Chair: M. Hoffman reported on the Organix, Inc. available to all. Attendees are Boston National ACS Meeting: The Polymedica Corp. requested to bring an unwrapped toy total attendance was 17,800. NESACS which the YCC will donate to a local received Luminary Awards for Out- children’s charity. For more informa- standing Local Section YCC Event tion, please visit the YCC website at (the trip of 9 members of the German http://people.bu.edu/nsycc. N New Members Chemical Society’s Jungchemikerfo- Includes members relocated to the rum and their academic mentors to Northeastern Section Boston in May 2001 for a week-long participation in educational activities, Invitation to attend a Section NESACS News including the Northeast Student meeting ACS Scholars Research Conference, a symposium on You are cordially invited to attend The following 17 students are ACS chemical education in the US and Ger- one of our upcoming Section meetings Scholars in our Section: many, visits to educational institutions as guest of the Section at the social and a Red Sox baseball game. hour and dinner preceding the meeting. Felipe Anziani, MIT The other award was to NESACS Please call Marilou Cashman for a Pedro Arrechea, MIT for Outstanding Performance in the reservation, letting her know that you Jessica Bazick, Harvard Very Large Local Section category, are a new member. N Elisa Calimano, MIT especially for its chemistry education Nydia Clayton, MIT activities and National Chemistry Reuben Cummings, MIT Week activities. M. Hoffman also had Sharon Doku, Harvard received the comparative statistics for Directions Michael Duncan, Dartmouth the Very Large Sections and noted that To ArQule, Inc. Adan Farinas, Harvard chief differences, in comparison with the New York and California Sections, 19 Presidential Way, Woburn, MA Christina Ann Fields, Harvard which are the other Very Large sec- From 93 North and South: Lauren Goins, Harvard tions, was in meeting attendance, Take Exit 37C from I-93. At the light at Daniel Golab, Harvard which (correcting for a reporting error) the end of the ramp, turn right. *Pro- Roy Hughes, Jr., Harvard was about half that as compared with ceed approximately 0.4 miles past Christiana Obiaya, MIT CA and NY. He noted that items which Genuity and the parking garage. Take Keith Reed, MIT were left blank in the annual report by the next left into ArQule, park in the Marlita Taylor (Nesacs Scholar), MIT NESACS which should be done: main- area marked for Visitors. The visitor’s Ida Wahlquist-Ortiz, MIT tenance of the job manual, membership entrance to the building is the one fac- surveys, media coverage of Section ing Presidential Way . We Welcome these Scholars to our Sec- activities. tion N From I-95 North: M. Hoffman announced election Take Exit 36 (Washington Street). At results for 2003 positions (see the the light at the end of the ramp, take a The NESACS website Summer issue, p.4). He also announced left turn into Washington Street. At the that the James Flack Norris Award in next light, turn left into Mishawum Rd. Physical-Organic Chemistry will be Get into the right lane, and turn right WWW.NESACS.org awarded at the 2003 Spring Meeting to into Commerce Way (Citizens Bank is Robert G. Bergman, University of Cal- at the corner). Stay on Commerce Way ifornia at Berkeley. through two sets of lights. At the sec- Have you looked at it? Chair-Elect: J. Neumeyer announced ond set, Commerce Way becomes Pres- continued on page 6 idential Way. Follow * above. N 4 The Nucleus December 2002 Monthly Meeting Biography th Ronald T. Borchardt received the The 838 Meeting of the Northeastern Section of the American Ph.D. in Medicinal Chemistry from the Chemical Society Jointly with the Medicinal Chemistry Group University of Kansas-Lawrence in Symposium: Factors Influencing Oral Bioavailability in Drug Design 1970. After a postdoctoral year at the N.I.H at Bethesda, MD, in 1971 Dr.
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