Annual Report

ANNUAL REPORT

2003

Northeastern Section American Chemical Society

Local Section Name: Northeastern Section URL for Total Report: http://www.nesacs.org

5 1 Dr. John L. Neumeyer Chair 2003 Northeastern Section, ACS

2 TABLE OF CONTENTS (Pages numbered separately by section)

Pages PART I - QUESTIONNAIRE

Annual Report Questionnaire...... 7

PART II: ANNUAL NARRATIVE REPORT

Activities: National Chemistry Week ...... 14 Phyllis A. Brauner Memorial Lecture...... 14 YCC - Jungchemikerforum Exchange ...... 14 Student Research Conference...... 15 Connections to Chemistry...... 15 Establishment of Budget and Finance Committee ...... 16 Welcome Letter & Survey of New NESACS Members...... 16 Summary...... 16 2003 Goal Attainment 2003 Local Section Goals and Assessment...... 18 2003 Chair's Goals and Assessment ...... 18 2004 Goals...... 19 Suggestions / Concerns...... 19 ACS Strategic Thrusts...... 19

PART II - APPENDICES 1-5

APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

Supporting Documents for Activities National Chemistry Week ...... 23 Phyllis A. Brauner Memorial Lecture...... 28 YCC - Jungchemikerforum Exchange ...... 32 Student Research Conference...... 33 Connections to Chemistry...... 35 Establishment of Budget and Finance Committee ...... 36 Welcome Letter & Survey of New NESACS Members...... 37

APPENDIX 2 - BUDGETS AND LONG-RANGE PLAN

Report of the Treasurer ...... 39 2-A: Budget for 2003...... 40 Budget for 2004...... 42

2-B: Long-Range Plan ...... 44

APPENDIX 3 - MEMBERSHIP SURVEYS AND 2003 NEWSLETTER

3-A: Membership Survey Conducted in 2003 ...... 47

3-B: 2003 Newsletter...... 51 September, 2003, issue of The Nucleus uploaded to ACS online report (S.O.L.A.R.)

3 APPENDIX 4 - PUBLIC RELATIONS PLAN - TALKS TO PUBLIC - NEWSPAPER CLIPPINGS

4-A: Public Relations Plan...... 53 4-B: Talks to Public ...... 55 4-C: Press Release / NCW Activity...... 59

APPENDIX 5 - AS NEEDED BY SECTION: NESACS REPORTS

Officers, Councilors, Directors, and Committee Chairs 2003 ...... 62 Calendar of Activities 2003 ...... 68 Reports: Archivist...... 72 Awards Committee ...... 72 Awards Presented by the Northeastern Section...... 77 Brauner, Phyllis A. - Memorial Lecture...... 78 Constitution & Bylaws Committee...... 81 Continuing Education Committee...... 82 Corporate Funding ...... 85 Education Committee ...... 89 Education Committee / High School Subcommittee ...... 96 Esselen Award Committee...... 108 Government Relations Committee ...... 115 Long-Range Planning ...... 116 Medicinal Chemistry Group...... 119 Membership Committee ...... 125 National Chemistry Week Committee...... 127 NERM 2003 ...... 128 Nominating Committee...... 129 Norris Award Committee ...... 130 Professional Relations Committee...... 134 Program Committee / Chair-Elect ...... 134 Public Relations Committee ...... 136 Public Service Committee / Elementary Education Task Force ...... 140 Publications, Board of...... 140 Richards Medal Committee...... 145 Speakers' Bureau...... 146 Summerthing 2003...... 146 Treasurer ...... 148 Trustees, Board of...... 148

APPENDIX 5-A: Complete Event Programs

NSCRC...... 151 Connections to Chemistry...... 180

APPENDIX 6 - YOUNGER CHEMISTS COMMITTEE

Report of the Younger Chemists Committee...... 194

4 PART III - ANNUAL FINANCIAL REPORT

Part A: Statement of Revenues and Expenses Operating Fund...... 202 Part B: Balance Sheet as of 12/31/03 ...... 202 Addendum to Financial Report filed online with ACS...... 202

PART IV - SELF-NOMINATIONS FOR CHEMLUMINARY AWARDS

Outstanding Performance by Local Sections...... 204

Outstanding Local Section Younger Chemists Committee ...... 207 Outstanding Local Section YCC Event...... 209

Most Original Hands-on Activity or Chemical Demonstration (NCW)...... 211 Outstanding On-going NCW Event ...... 213

5 Annual Report Northeastern Section

PART I

ANNUAL REPORT QUESTIONNAIRE

http://www.nesacs.org

6 PART I - QUESTIONNAIRE

American Chemical Society

Form: Part I - Annual Report Questionnaire REQUIRED Organization: Northeastern Year: 2003

****Important Notice Please Read****

The EZ form consists of the Part I - Questionnaire, Part III - Financial Report and the Optional Part IV - Self- Nomination Form for ChemLuminary Awards. Sections that wish to submit the EZ form are not required to submit the Part II - Narrative and Appendices. All local sections are eligible to complete the EZ form UNLESS, they would like to self-nominate themselves for the LSAC Award for Outstanding Performance by a Local Section. Local sections may submit the EZ form and self-nominate themselves for any of the other awards listed in Part IV. Local Sections must postmark or submit their completed annual reports electronically by February 15, 2004 to be eligible for any of the awards

We do not wish to be considered for the Local Section Outstanding Performance Award

*Part I Annual Report Questionnaire *Part II Annual Report Narrative and Appendices (Optional) *Part III Financial Report *Part IV Self Nomination for ChemLuminary Awards (Not Eligible for Local Section Outstanding Performance Award (Optional) x - Our section would like to be considered for the ACS Local Section Outstanding Performance Award. We are submitting Parts I,II,III and IV of the annual report

*Part I Annual Report Questionnaire * Part II Annual Report Narrative& Appendices * Part III Financial Report * Part IV Self Nomination for ChemLuminary Awards (Outstanding Performance Award Nomination must be completed)

Web Posting of Annual Reports x - Our Section would like to have Parts I and II (if applicable) posted on the Local Section Activities Committee website.

1. New Activities

Number of new activities described in Part II A (Narrative). 2

Please list the titles of the new activities Establishment of Budget/Finance Committe Welcome Letter/Survey of New Members

2. Section Administration

7 EXECUTIVE COMMITTEE 2.1 How many times did the executive committee meet during 2003? 9 2.2 How many members are on the executive committee? 63 2.3 How many section meetings were held in 2003? 9 2.4 On average, how many members attend regular meetings? 79 COUNCILORS 2.5 What percentage of the section's Councilors were in official attendance at the ACS spring Council meeting? 100% 2.6 What percentage of the section’s Councilors were in official attendance at the ACS fall Council meeting? 100% 2.7 How do Councilors report to the section about national ACS matters? (check all that apply) at a section meeting x-at an executive committee meeting x-in the newsletter x-on the local section website

COMMITTEES 2.8 Specify active committees having two or more members. x-Awards x-Newsletters/Publications x-Budgets/Finance x-Nominations x-Career Assistance x-Professional Relations x-Chemistry Olympiad x-Project SEED x-Continuing Education x-Public Relations x-Education x-Senior Chemists x-Environmental x-Environmental Health and Safety/ Chemical Hygiene x-Government Affairs Women Chemists x-Industry Relations x-Younger Chemists x-Long-Range Planning Other: Local Arrangements x-Membership/Member Retention Other: Constitution & Bylaws x-Mentoring Other: Brauner Memorial Lecture Minority Affairs Other: Summerthing x-National Chemistry Week

SUBSECTIONS 2.9 How many subsections are active in the section? 0 2.10 How many subsection meetings were held in 2003? 0

Topical Groups 2.11 How many topical groups are active in the section? 1 2.12 How many topical group meetings were held in 2003? 3

OPERATIONS AND PLANNING (Check all that apply) 2.13 x-The section prepared a budget for 2003 (Please include a copy in Part II Appendix 2) 2.14 x-The section prepared a budget for 2004 (Please include a copy in Part II, Appendix 2) 2.15 x-The section prepared a long-range plan (Please include a copy in Part II, Appendix 2) 2.16 x-The section maintains and uses a current job manual prepared by the section as a guide for officers and committees. 2.17 x-The section conducted a membership survey in 2003 to determine member's interests and needs (Please include a copy in Part II, Appendix 3) 2.18 x-A section representative attended a Local Section Leadership Conference during 2003.

SECTION COMMUNICATION 2.19 How many newsletters were published in 2003? 10 2.20 x-One copy of a newsletter is included in Appendix 3. 2.21 How many meeting notices were published in 2003? 27 2.22 x-The section has an active website. URL: http://www.nesacs.org 2.23 x-The section used electronic communication.

8 2.24 x-The section posted its 2002 Annual Report on its website.

SECTION ELECTIONS 2.25 How many members voted in the 2003 officer election? 653

SECTION AWARDS (check all that apply) 2.26 The section submitted a nomination for the ACS Regional Award in High School Chemistry Teaching during 2003.

The section gave awards or a Salutes to Excellence to: 2.27 Primary school students (K-6) 2.28 x-Secondary school students (7-12) 2.29 x-College students 2.30 Primary school teachers (K-6) 2.31 x-Secondary school teachers (7-12) 2.32 x-College teachers 2.33 x-Members of the local section for service 2.34 x-Outstanding chemist(s), regardless of section affiliation 2.35 The section or local company encouraged and/or submitted a nomination for the ACS Regional Industrial Innovation Awards.

SECTION AFFILIATES 2.36 How many paid section affiliates excluding students (teachers, technicians, others) are there in the section? 26 2.37 Section has supported an existing Technician Affiliate Group (TAG)during 2003. 2.38 Section has promoted the formation of a Technician Affiliate Group during 2003

3-12. ACS Strategic Thrusts

Be the world's leading provider and deliverer of chemical information (Check all that apply) 3.1 The section organized a regional meeting. An ACS Technical Division was involved. 3.2 The Section organized a symposium. An ACS Technical Division was involved. 3.3 The organized a Meeting-in-Miniature. An ACS Technical Division was involved. 3.4 x-The section organized an undergraduate research symposium. An ACS Technical Division was involved. 3.5 The section organized a meeting that was co-sponsored by an ACS Technical Division.

Provide programs and activities to facilitate the career development of chemical professionals. (Check all that apply) 4.1 x-The section published articles on employment services in its newsletter or website. 4.2 x-The section sponsored local employment services (e.g., free ads in section newsletter or website, job counseling, employment clearing house) 4.3 x-A section representative attended a Local Section Career Program during 2003 4.4 x-The section referred individuals to national ACS Depart of Career Services. 4.5 x-The section maintained a job line for positions available within the local section. 4.6 x-The section hosted an ACS short course. 4.7 How many local section career programs or activities were conducted in 2003? 8 4.8 Of the local section programs that were conducted in 2003, how many were new? 0 4.9 x-The section offered career counseling/literature.

Provide programs to improve the scientific literacy of students and ensure quality education in the chemical sciences (Check all that apply) 5.1 Providing Judges for area science fair(s)

9 5.2 Sponsoring awards at area science fair(s) 5.3 x-Members make visits to K-12 classrooms. 5.4 x-Member presented career programs for students 5.5 x-Distributing career literature to students or schools. 5.6 x-Sponsoring or organizing student competitions (e.g., chemistry examinations, Chembowls, poster competitions) 5.7 x-Conducting teacher workshops 5.8 x-Inviting teachers to attend section meetings 5.9 x-Providing teachers with free subscriptions to magazines or journals 5.10 x-Involving teachers in section program planning 5.11 x-Presenting chemical demonstrations 5.12 x-Participating in Project SEED 5.13 x-Participating in US National Chemistry Olympiad

Increase participation of students and young chemists in activities of the society (Check all that apply) 6.1 x-The section provided services for pre-college students. 6.2 x-The section provided speakers for student affiliate chapter meetings. 6.3 x-The section organized tours of local industries for student affiliate chapters. 6.4 x-The section offered financial support for student affiliate chapter activities. 6.5 x-The section offered financial support to students attending regional or national meetings undergraduate or graduate 6.6 x-The section appointed a member as student affiliate chapter liiaison 6.7 x-The section members served as non faculty professional advisors or contacts for students and young chemists 6.8 x-The section provided students with free subscriptions to journals. 6.9 x-The section invited student affiliates to attend regular section meetings. 6.10 The section sponsored a teacher affiliate group to engage students in ACS. 6.11 x-The section involved student affiliates in National Chemistry Week activities. 6.12 x-The section distributed career literature to students or to college and universities.

Provide programs and activities to encourage participation and leadership in all aspects of the chemical sciences by women (W) underrepresented minorities (M) and persons with disabilities (D) (Check all that apply) W M D 7.1 x x x Section members mentored students or colleagues 7.2 x x x The section sponsored hands-on science activities in underserved communities. 7.3 x x x The section provided summer research opportunities. 7.4 The section developed science career fairs at high schools or colleges that have high female, minority or disabled populations. 7.5 The section organized summer science camps. 7.6 x x x The section sponsored contests or awards. 7.7 x x x The section maintained employment services

Expand Services to members and prospective members working in industry. (Check all that apply) 8.1 x-The section offered specifically tailored symposia, seminars, or sponsored activities for industrial chemical members. 8.2 x-Industrial members are active in the section's governance. 8.3 x-The section communicated with non-ACS members working in industry and local companues about meetings and programs. 8.4 x-Local companies have financially sponsored and activity or donated money to the section. 8.5 Industrial members (M), local companies (C), and/or non-members employed in industry (N) participated in these section programs or activities. M C N Meeting at industrial site/plant tour x x x Local Section Award/Recognition program x x x Membership Drive for new members

10 x x x Industrial speaker/Industrially focused topic x x x NCW or community activities x x x Career Development activities x x x Student or younger chemist activities

Expand activities at the interdisciplinary boundaries of chemistry 9.1 x-The section has topical groups in interdisciplinary areas. 9.2 x-The section has sponsored meetings with an interdisciplinary focus. 9.3 The section is affiliated with other technical or scientific societies or consortia. 9.3a If the section has a formal affiliation with (Name of organization) This affiliation was approved by ACS council in what year 9.4 x-The section held a meeting jointly with another professional organization.

Encourage funding of research in science, technology and engineering. 10.1 Local section members interacted with federal government officials (i.e., members of congress, agency staff, etc.) to encourage funding of research

Encourage activities and program applying scientific principles to environmental issues 11.1 x-The section offered activities such as symposia, seminars, or sponsored student activities on environmental issues.

Provide programs and activities to improve the public's recognition and appreciation of the contributions of chemistry.(Check all that apply) 12.1 The section maintained an experts roster and provided it to local media. 12.2 x-The section created or updated a media list. 12.3 x-The section prepared a public relations plan and included a copy of this plan in Appendix 6. 12.4 How many times were section activities promoted to the local media (press releases, op-eds, advisories, etc.)? 18 12.5 x-The section used an ACS film, videotape, or other ACS visual-aid resource at a public event. 12.6 How many talks were given by section members to the public in 2003? 82 12.7 x-The section conducted a chemical hygeine, responsible care or environmental health and safety event for the general public. 12.8 x-The section offered its services to the local community as a resource on chemical hygeine, responsible care or environmental health and safety. 12.9 x-The section carried out environmental activities for the general public.

12.10 The section participated in or conducted the following community activities: Chemists Celebrate Earth Day Chemists in the Library Chemagination Contest x-NCW NCW Youth Patch Activity Program 12.11 The section conducted the following activities during NCW 2003: x-Hands-on activities x-Chemical Demonstrations Contests or games x-Lectures or training Other: Undergraduate Day 12.12 The section's NCW Activities were carried out in the following venues: K-8 schools x-High Schools x-Colleges or Universities Industrial Sites x-Museum/Libraries Shopping Malls Other 12.13 The section worked with the following group(s) to produce NCW events: K-8 schools x-High Schools x-Colleges or Universities x- Industry x-Museums or Libraries Scout Troops Civic Orgnizations Other 12.14 The section publicized NCW via: x-Newspapers/magazines/flyers x-Radio Television x-Website

11 12.15 The section participated the NCW unifying event in 2003. 12.16 What is the total number of year that the NCW coordinator has served in this capacity? 1 12.17 x-The section has a Government Relations Representative. 12.18 The section invited state or federal government officials to speak at a local section meeting. 12.19 The section organized or participated in a special government relations event(state capitol day, science town meeting, legislative hearing, public policy forum, etc.). 12.20 The section informed its members on legislative issues and events through newsletter article, website, or other communications method. 12.21 The section member(s) held an office or key position in state or federal government in 2003.

12 ANNUAL REPORT Northeastern Section, ACS

PART II

ANNUAL NARRATIVE REPORT

http://www.nesacs.org

13 PART II - NARRATIVE

Form: Part II - Annual Narrative Report Optional for EZ Submission Organization: Northeastern Year: 2003

A. Activities Please describe and rank up to ten of your section's activities during 2003. Provide (a) the title of the activity, (b) a one paragraph description of the activity, and (c) an indication of which ACS Strategic Thrusts. Please refer to the end of this section for a listing of the ACS Strategic Thrusts or see Part I, questions 3-12. If you wish to provide details beyond these paragraphs, please do so in Appendix 1.

Activity #1 a) Title: National Chemistry Week b) Description (please limit to one paragraph): On Sunday, October 19th, the Phyllis A. Brauner Memorial Lecture held at Wellesley College initiated the Northeastern Section's National Chemistry Week. A lecture by Dr. Bassam Shakhashiri from the University of Wisconsin on "Earth's Atmosphere and Beyond" was attended by a large crowd of over 1,000 students, their parents and teachers. Later in the week a symposium was hosted by MIT on the theme, "What's New in the Air? -- Atmospheric Chemistry in the 21st Century" Four related topics were presented by speakers and discussed by a panel of experts. During the events, volunteers from local schools and industries assisted the hundreds of visitors in understanding and appreciating the world we live in. c) Which Strategic Thrust(s) does this activity support? (Please refer to the List of Strategic Thrusts) 1 2 3 4 5 6 7 8 9 10 (No) This activity was new in 2003

Activity #2 a) Title Phyllis A. Brauner Memorial Lecture b) Description (Please limit to one paragraph) The late Dr. Brauner was an active and dedicated member of the faculty of Simmons College and Framingham State College and served as a Past-Chair of the NESACS, Editor of The Nucleus, Councilor, and Trustee and was a recipient of the Henry A. Hill Award for Outstanding Service to the Northeastern Section. The NESACS established the Phyllis A. Brauner Memorial Lecture Endowment in 2002 to support this lecture annually during National Chemistry Week. A Phyllis A. Brauner Memorial Book Award is also presented annually at the Northeast Student Chemistry Conference to the student who gives the best talk or poster. c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 7 8 9 10 (No) This activity was new in 2003

Activity #3 a) Title YCC-Yungchemiker Forum Exchange b) Description (Please limit to one paragraph)

14 The Northeastern Section and its Younger Chemists Committee continued the exchange of students for the third time in 2003. In 2001 the Northeastern Section hosted a group of students and faculty from Germany in Boston, and in 2002 the Gesellschaft Deutscher Chemiker (German Chemical Society) hosted 12 students from the NESACS. Again in 2003, the NESACS sponsored 11 students from the local universities together with four faculty and industrial representatives. The first conference was held at the Technical University of Munich where a Career Symposium was held. Dr. John Neumeyer, the current Chair of the NESACS, gave a welcoming address and introductory remarks. The ACS 2003 President, Dr. Elsa Reichmanis, discussed the importance to research collaborations and teamwork between Europe and the United States. The second half of the trip took the group to Dresden for the Eurogionale Conference held at the Technical University of Dresden. c) Which strategic thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 7 8 9 10 (No) This activity was new in 2003

Activity #4 a) Title: Student Research Conferences b) Description (Please limit to one paragraph) The NESACS again organized two student research conferences in 2003. On April 26, the Northeast Chemistry Conference was held at Boston University for the purpose of bringing together undergraduate students and post-doctoral fellows from the northeastern region of the country. In addition to poster sessions, there were five student speakers and a guest lecturer, Dr. Charles Lieber of Harvard University, who spoke on "Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things." The 12th Annual Northeastern Undergraduate Day was held at Boston University on November 1. The program included research talks and seminars by faculty from MIT, Perkin-Elmer, and Boston University, as well as a Student Affiliate Workshop. c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of strategic thrusts.) 1 2 3 4 5 6 7 8 9 10 (No) This activity was new in 2003

Activity #5 a) Title Connections to Chemistry b) Description (Please limit to one paragaph) On October 8, the Education Committee organized the Fourth Annual Connections to Chemistry--High School Teachers Workshop at Burlington (MA) High School. The program was focused on presenting high school chemistry teachers in the New England area with the extensive educational resources of the ACS and the Northeastern Section. The program speaker was Sally Mitchell, East Syracuse-Minoa Central High School, East Syracuse, NY. She was also the awardee of the Northeast Regional ACS Outstanding High School Teacher Award c) Which Strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts) 1 2 3 4 5 6 7 8 9 10 (No) This activity was new in 2003

15 Activity #6 a) Title: Establish Budget & Finance Committee b) Description (Please limit to one paragraph) Although the NESACS is financially well-endowed, there was a need to meet and monitor the budget of the Section more than once a year when the budget was traditionally drawn up. The Budget & Finance Committee is made up of six members with the Treasurer of the Northeastern Section serving as Chair. The remaining five members were members of the Board of Directors as well as one member from the membership at large. The members of the committee were appointed by the Chair. The committee prepared a budget for 2004 and met four times during the year to evaluate the level of 2003 expenditures versus income of the Section. c) Which Strategic Thrust(s) does this Activity Support? (Please refer to the list of Strategic Thrusts. 1 2 3 4 5 6 7 8 9 10 (Yes) This activity was new in 2003

Activity #7 a) Title Welcome Letter and Survey of New Members b) Description (Please limit to one paragraph) The Membership Committee sent letters to the more than 1,300 new members of the Section, inviting them to the monthly meeting and as its guest at the dinner that precedes the lecture by the invited speaker. A Welcome Letter and Survey of Interests was also sent to all new members by the Chair of the Section. During 2003, forty-three responses were received which facilitated contacts with these new members and indicated committees in which these members would like to participate. c) Which strategic Thrust(s) does this activity support? (Please refer to the list of Strategic Thrusts). 1 2 3 4 5 6 7 8 9 10 (Yes) This activity was new in 2003

B. Summary - Overall Section Activities

Please summarize in 1,000 words or less, the activities of the section in 2003 which have not been already described. Outstanding events should be described in some detail and appropriate attachments included in Appendix 1. Programs described here may be featured in publications produced by the ACS Membership Division and/or at the Local Section Leadership Conferences.

I was honored to have been elected to serve as the Chair of the Northeastern Section for 2003. This is one of the largest and most active sections in the ACS with a most impressive list of universities, industries and research institutes, matched nowhere else in the world. One of my goals as Chair was to bring to the attention of the public the role that chemists play in our society and to improve the public's perception of chemicals and chemists. The environmental problems are too numerous to discuss here, but we hoped that each of us would make some small contribution to help solve these problems. We hoped to bring to the attention of educators, researchers and policy makers the public's general lack of concern about the environment by discussing these issues with them.

Our Section's Fields of Interest as reported by the ACS Demographic Report in 2002 paralleled the national membership quite closely: Organic Chemistry (15%), Medicinal/Pharmaceutical Chemistry

16 (10%) and Analytical Chemistry ranking third with nine per cent. When we examined the Nature of the Business in this report, thirty per cent were in the manufacturing sector and twenty-two per cent are employed in four-year universities/colleges. The Northeastern Section has a significantly larger number of chemists working in independent laboratories--eight per cent locally versus five per cent nationally. The membership is made up of 25% women locally compared to 21% nationally. Interestingly though, our Board of Directors is made up of 37% women. The Section is fortunate in being financially well- endowed and was able to provide a wide range of programs and services for its broad large membership base. The Section maintained its connections to legislative action, expanded its public relations capability and re-activated a Speakers' Bureau. It engaged in long-term planning, and established a Finance Committee to monitor the income and expenses of the Section throughout the year. Our National Chemistry week events at Wellesley College attracted over 1,000 students, their parents and their teachers, as well as members of the general public. A symposium on the theme, "Earth's Atmosphere and Beyond" was sponsored by this Section and this year incorporated the Phyllis A. Brauner Memorial Lecture delivered by Dr. Bassam Shakhashiri. A symposium was held later in the week at the Massachusetts Institute of Technology (MIT) on the theme "What's New in the Air? Atmospheric Chemistry in the 21st Century."

The Membership Committee sent letters to the more than 1,300 new members of the Section, inviting them to the monthly meeting and as its guest at the dinner that precedes the lecture by the invited speaker. A Welcome Letter and Survey of Interests was also sent to all new members by the Chair of the Section. Attendance at the meetings of the Board of Directors which precedes the monthly meetings was excellent. Eight monthly meetings of the Executive Committee were also held during the year. The meeting in June of the whole Board was dedicated to a Long-Range Planning Meeting.

Our Section organized and sponsored a number of significant events and lectures during the year. For the second year in a row, the Section sponsored an all-expense-paid trip to Munich and Dresden for eleven students. The exchange between our Younger Chemists Committee and the Jungchemiker Forum of the German Chemical Society was successful and rewarding. This exchange offered students the opportunity to present research in an international forum, to learn about career opportunities in Germany and the United States and to explore foreign culture as well as to make international contacts and new friends.

During 2003, the Section sponsored and presented the James Flack Norris Award in Physical Organic Chemistry to Dr. Robert G. Bergman of the University of California/Berkeley at the ACS National Meeting in New Orleans in the spring of 2003. In addition, the Section presented the Gustavus J. Esselen Award to Dr. Bruce D. Roth for the discovery and development of Lipitor ®. The award recognizes "a chemist whose scientific and technical work has contributed to the public well-being and has thereby communicated positive values of the chemical profession." The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry was also awarded to Dr. David N. Harpp. The Henry A. Hill Award for Outstanding Service to the Northeastern Section was presented to Dr. Doris I. Lewis (Suffolk University). For a complete listing of the awards presented by the Northeastern Section in 2003, please see the report of the Awards Committee in Appendix 5, page 18.

To summarize, we can say that the year 2003 was successful in all respects. The section was honored by receiving three ChemLuminary Awards at the National Meeting in New York City in September. The awards received were in the following categories: Committee on Local Sections: Outstanding Performance by a Local Section--Very large Section, Committee on Minority Affairs: Outstanding ACS Scholars Program, and National Chemistry Week Task Force: Outstanding Event for the General Public Using the Yearly Theme. In addition, the Northeastern Section was named as an award finalist in the categories of National Chemistry Week Most Original Hands-On Activity or Chemical Demonstration and Outstanding Local Section Younger Chemists Committee Event.

17 We are proud of our accomplishments throughout the year and of all our members who worked so hard to accomplish our goals and to provide programs and activities of benefit to members of the Northeastern Section.

C. Local Section and Chair Goals

1. 2003 Goal Attainment. The Local Section Activities Committee strongly encourages local section planning. As a result, the 2003 local section annual report should follow-up on the attainment of goals. Please list the goals you set at the beginning of your term for your section and yourself, and report on the attainment of the goals. a) Local Section Goals and Assessment: 1. Goal: Increase involvement of new members in the activities of the Section Assessment: Our efforts to motivate younger chemists as officers in the Section has borne fruit. A number of younger chemists have taken on leadership roles on committees and on the Board of Directors. Our Chair-elect in 2004 came from the Chair of the YCC. Younger chemists from academia and universities have been recruited to run for elected officers in the Section.

2. Goal: Update communication with Section members by updating and change in management of web site Assessment: Efforts are in progress to separate the management of the web site from the Publication Committee which is responsible for the publication of The Nucleus, our monthly newsletter. The web site has improved considerably in the last year under the leadership of a new webmaster, a part-time volunteer.

3. Goal: Balance Section's budget and greater fiscal monitoring by more frequent meetings of Budget & Finance Committee Assessment: Although the fiscal management of the budget is now under greater scrutiny than previously, continuing efforts by the current leadership will require greater vigilance and understanding of the finances of the Section and the equitable distribution of funds.

b) 2003 Chair's Goals and Assessment:

1. Goal: Better communication with rank and file membership; encourage younger chemists' and new members' participation in the Section's activities Assessment: (Same as Section Goal 1-a Assessment) Our efforts to motivate younger chemists as officers in the Section has borne fruit. A number of younger chemists have taken on leadership roles on committees and on the Board of Directors. Our Chair-elect in 2004 came from the Chair of the YCC. Younger chemists from academia and universities have been recruited to run for elected officers in the Section.

2. Goal: Increase integration of sub-groups (i.e., Medicinal Chemistry Group) in our Section Assessment: The Medicinal Chemistry sub-group has for many years been running their own programs except for one joint meeting per year. Efforts are now underway to integrate the programs of the Medicinal Chemistry Group into the Section activities. A number of members of the Medicinal Chemistry Group are now on the Board of Directors of the Section.

3. Goal: Focus on fund-raising from industries in the Section

18 Assessment: Fund-raising in 2003 was somewhat of a disappointment. Although the amount of funds raised was equivalent to that raised in the previous two years, the dollar goals of this committee were not set. A new committee was organized to more effectively raise funds from industrial and non-industrial sources in 2004, and increase the personal contacts with potential donors. a) 2004 Local Section Goals (Include at least three goals):

1. Revitalize the Public Relations committee to increase media coverage of the Section’s activities, especially our NCW, Education and Monthly meetings programs.

2. Increase membership on Section’s committee; assign members to committees based on information from the informal feedback sheets.

3. Reduce Section's expense for monthly meetings by seeking different and less costly host-site for monthly meetings.

4. Alter the general content and aesthetics of the Section’s newsletter, The Nucleus; increase the number of photographs depicting attendees at Section’s activities. b) 2004 Chair’s Goals:

1. Conduct membership survey to better ascertain Section members need

2. Increase integration of sub-groups (i.e., Medicinal Chemistry Group) in our Section

3. Broaden Section’s fund-raising solicitation to include Chemistry and Non-Chemistry agencies.

4. Provide more printed information and workshops targeted to middle-aged unemployed or under- employed Section chemist to increase their marketability.

D. Suggestions/Concerns

List any suggestions you have for the Local Section Activities Committee (LSAC). How can LSAC specifically help your section?

· Make suggestions on how to motivate young chemists to participate in local section activities

Listing of Strategic Thrusts Please refer to the numbers below when identifying activities as they relate to the ACS Strategic Thrusts:

1 Be the world's leading provider and deliverer of chemical information. 2 Provide programs and activities to facilitate the career development of chemical professionals 3 Provide programs to improve the scientific literacy of students and ensure quality education in the chemical sciences. 4 Increase participation of students and young chemists in the activities of the society. 5 Provide programs and activities to encourage participation and leadership in all aspects of the chemical sciences by women (W), underrepresented minorities (M), and persons with disabilities (D).

19 6 Expand services to members and prospective members working in industry. 7 Expand activities at the interdisciplinary boundaries of chemistry. 8 Encourage funding of research in science, technology, and engineering . 9 Encourage activities and programs applying scientific principles to environmental issues. 10 Provide programs and activities to improve the public's recognition and appreciation of the contributions of chemistry.

For more information on the strategic thrusts or the ACS Strategic Plan 2001-2003 please visit www.chemistry.org.

20 ANNUAL REPORT Northeastern Section, ACS

PART II - APPENDIX 1

SUPPORTING DOCUMENTS FOR ACTIVITIES

http://www.nesacs.org

21 APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

APPENDIX 1 - CONTENTS Supporting Documentation for Part II - Narrative

Activity 1 - National Chemistry Week ...... 23 Report from NCW Chair ...... 23 From NESACS Calendar of Activities ...... 23 Program Schedule - Undergraduate Day...... 24 From Connections to Chemistry Program: Brauner Lecture / Wellesley College Program...... 26 MIT Symposium Poster...... 27

Activity 2 - Brauner Lecture...... 28 Report from the Brauner Lecture Committee...... 28 Brauner Memorial Lecture Poster - See Activity 1: NCW...... 26 Invitation Letter to Wellesley College Lecture ...... 29 Request for Funding - Foundations ...... 30 From Minutes of Long-Range Planning Meeting...... 31 Press Release...... 31

Activity 3 - German Exchange Program...... 32 Report from YCC ...... 32 See also Appendix 6: Report of the Younger Chemists Committee ...... 194

Activity 4 - Student Research ...... 33 From the Education Committee Report - NSCRC...... 33 From the YCC ChemLuminary Self-Nomination ...... 33 From the Education Committee Report - Environmental Research Symposium...... 33 From the Education Committee Report - Norris-Richards Undergraduate Summer Research Scholars ...... 33 From the Education Committee Report - Grants-in-Aid to Undergraduates...... 34 See Appendix 5-A for complete NSCRC Program ...... 151

Activity 5 - Connections to Chemistry ...... 35 From the Education Committee Report ...... 180 See Appendix 5-A for complete Connections to Chemistry Program

Activity 6 - Establishment of Budget & Finance Committee...... 36 From the Minutes of the Long-Range Planning Committee ...... 36 See Appendix 5: Corporate Funding Report ...... 85

Activity 7 - Welcome Letter & Survey of New NESACS Members...... 37 See Appendix 3-A for copies of Chair's Letter, Survey Form and Survey Results...... 47

22 SUPPORTING DOCUMENTATION: ACTIVITY 1 -- NATIONAL CHEMISTRY WEEK

Report from NCW Chair

Northeastern Section of the American Chemical Society 2003 National Chemistry Week Celebration

On Sunday, October 19, 2003, the Northeastern Section of the American Chemical Society and Wellesley College sponsored and hosted a 2003 National Chemistry Week celebration focusing on the yearly theme Earth’s Atmosphere and Beyond.

For weeks before the celebration, volunteers from Emmanuel College, Merrimack College, Suffolk University, Tufts University, and Wellesley College worked out the details of numerous demonstrations and hands-on activities.

These activities included: · making UV detectors (bracelets) using UV-sensitive beads and comparing the effectiveness of sunscreens; · making humidity testers with cobalt chloride impregnated paper; · the plane smarts activity taken from “Celebrating Chemistry – Earth’s Atmosphere and Beyond, p. 2”; · demonstrations of tornadoes and volcanoes; · a demonstration of acid rain; · a demonstration of cloud formation.

Among the highlights of the day, Professor Bassam Shakhashiri of the University of Wisconsin-Madison gave two presentations of the Phyllis A. Brauner lecture entitled Earth’s Atmosphere and Beyond. The captivating lectures were enjoyed by children and adults alike.

On Thursday, October 23, 2004 the Northeastern Section of the American Chemical Society and Massachusetts Institute of Technology hosted and sponsored a symposium entitled What’s New in the Air? Atmospheric Chemistry in the 21st Century. Participants in the symposium included Luisa T. Molina, Charles E. Kolb, Daniel J. Jacob, James G. Anderson. Throughout the two days of activities, volunteers from local schools and industries assisted hundreds of visitors in the week-long celebration in appreciation of chemistry in the world around us.

From NESACS Calendar of Activities

October 19 Phyllis A. Brauner Memorial Lecture / Wellesley College Science Center Dr. Bassam Shakhashiri / University of Wisconsin Topic: Earth's Atmosphere & Beyond (two presentations) Kicking off National Chemistry Week 2003 Festivities Variety of hands-on activities

October 23 NCW Symposium: What's New in the Air? Atmospheric Chemistry in the 21st Century - MIT Mario J. Molina / MIT Topic: Improving Air Quality in Megacities: Mexico City Case Study Daniel J. Jacob / Harvard University Topic: Air Pollution and Climate Change James G. Anderson / Harvard University Topic: Spectroscopy and Climate Change: Benchmark Observations and Forecast Testing Panel to Answer Questions on the Changing Atmosphere Panelists: Luisa T. Molina / MIT Mario J. Molina / MIT Daniel J. Jacob / Harvard University James G. Anderson / Harvard University Charles E. Kolb / Aerodyne Research

23 November 1 Twelfth Annual Northeast Regional Undergraduate Day / Boston University Keynote Speaker: Prof. Thomas Pochapsky / Brandeis University Topic: Metalloproteins and Metalloenzymes Research Talks & Seminar Prof. Sarah E. O'Connor / MIT Topic: The Biosynthesis of Natural Products Dr. Scot Pounds / Perkin-Elmer Topic: Shortening the Pipeline: Bringing Drugs to Market When Time Is Money Prof. Alex Golger / Boston University Topic: Demonstrations in Chemistry to Fascinate Kids Prof. Scott Schaus / Boston University Topic: Choosing a Graduate School Resume' Review and Graduate School/Industry Fair Dr. Frank Wagner / Strem Chemicals Topic: Preparing Your Resume' Research Talks & Seminar Prof. Sean Elliott / Boston University Topic: Moving Electrons through Proteins Dr. Aaron Beeler / Boston University Topic: Parallel Synthesis and Chemical Library Development including tour of BU Center for Chemical Methodology & Library Development Student Affiliates Workshop Prof. Anthony Fernandez / Merrimack College Topic: Resuscitating a Shallow-Breathing Student Affiliates Chapter

Program Schedule - Undergraduate Day Celebrating National Chemistry Week 12th Annual Northeast Regional Undergraduate Day Saturday, November 1, 2003 Hosted by the Department of Chemistry, Boston University, and Chemia Sponsored by the Northeastern Section of the American Chemical Society

9:00 Registration (Metcalf Science Center, 590 Commonwealth Avenue, Boston) 9:30 Welcoming Remarks Professor John Snyder, Associate Chair, Chemistry Department, Boston University Professor Morton Hoffman, Immediate Past-Chair, Northeastern Section Penny Lancaster, President, Chemia (ACS Student Affiliates Chapter at B.U.) 9:45 Keynote Address: Professor Thomas Pochapsky, Brandeis University: Metalloproteins and Metalloenzymes. 10:30 Coffee break 10:45 Research Talk and Seminar (choose one) Professor Sarah E. O’Connor, Massachusetts Institute of Technology: The Biosynthesis of Natural Products Dr. Scot Pounds, Perkin-Elmer: Shortening the Pipeline: Bringing Drugs to Market When Time is Money 11:30 Workshop and Seminar (choose one) Professor Alex Golger, Boston University: Demonstrations in Chemistry to Fascinate Kids Professor Scott Schaus, Boston University: Choosing a Graduate School 12:00 Résumé Review and Graduate School/Industry Fair Dr. Frank Wagner, Strem Chemicals: Preparing Your Résumé Graduate School and Industry Fair (12:00–1:30 p.m.)

24 12:30 Lunch 1:30 Technical Talk and Seminar (choose one) Professor Sean Elliott, Boston University: Moving Electrons through Proteins Dr. Aaron Beeler, Boston University, CMLD: Parallel Synthesis and Chemical Library Development (includes a tour of the B.U. Center for Chemical Methodology and Library Development) 2:15 Student Affiliates Workshop Professor Anthony Fernandez, Merrimack College: Resuscitating a Shallow–Breathing Student Affiliates Chapter 3:00 Adjournment

There will be a $5 registration fee to cover partially the cost of lunch, which will be provided, and workshop materials. If you would like more information, or if your school or company would like to send a representative to the Graduate School and Industry Fair, please contact Kevin Burgoyne at 617–353–2503; fax: 617–353–6466; e-mail: [email protected]).

25 From the Connections to Chemistry Program

National Chemistry Week Earth’s Atmosphere and Beyond!!

Phyllis A. Brauner Memorial Lecture by Dr. Bassam Shakhashiri Dr. Bassam Shakhashiri is a Professor of Chemistry at the University of Wisconsin-Madison and is the William T. Evjue Distinguished Chair for the Wisconsin Idea. Professor Shakhashiri has captivated audiences with his scientific demonstrations at a variety of locations including Boston’s Museum of Science, the National Academy of Sciences and the Smithsonian's National Air and Space Museum in Washington.

Sunday, October 19, 2003 11 am – 12 pm repeated from 2 pm – 3 pm Wellesley College, Science Center, Room 277

The Sunday presentations are free and open to the public. Tickets are available on a first come, first serve basis though reservations are recommended. To reserve tickets, please contact Marilou Cashman either via email [email protected] (preferred) or by phone 1-800-872- 2054. Tickets will be available for pick-up outside of the Science Center on the 19th. Parking is free. For directions to Wellesley College, visit http://www.wellesley.edu/Admin/travel.html. While at Wellesley, a visit to the arboretum and greenhouses (which are open to the public) is a must. For more information, visit http://www.wellesley.edu/FOH/greenhouse.html.

Kicking off National Chemistry Week 2003 festivities Join us in a variety of hands-on activities including making UV and humidity testers as well as demonstrations regarding Earth’s atmosphere. Taking place from 10 am – 4pm on October 19, 2003 outside of the Wellesley Science Center. In case of rain, these activities will take place indoors. For more information, please visit www.nesacs.org.

26 MIT Program flyer mailed and e-mailed to publicize NCW activities; see Activity 2/Brauner Lecture for Wellesley College Program flyer National Chemistry Week 2003

Symposium What's New in the Air? Atmospheric Chemistry in the 21st Century Massachusetts Institute of Technology Thursday, October 23, 2003 7:00 pm, Eastman Lecture Hall, Room 6-120 Open to the Public

Program:

7:00 Northeastern Section of the American Chemical Society Welcome Doris Ingram Lewis, Suffolk University 7:05 Massachusetts Institute of Technology Welcome Luisa T. Molina, Massachusetts Institute of Technology 7:10 Introduction Charles E. Kolb, Aerodyne Research 7:15 Improving Air Quality in Megacities: Mexico City Case Study Mario J. Molina, Massachusetts Institute of Technology 7:45 Air Pollution and Climate Change Daniel J. Jacob, Harvard University 8:15 Break 8:45 Spectroscopy and Climate Change: Benchmark Observations and Forecast Testing James G. Anderson, Harvard University 9:15 Panel to Answer Questions on the Changing Atmosphere L.T. Molina, M.J. Molina, D.J. Jacob, J.G, Anderson, C.E. Kolb

Sponsored by the Northeastern Section of the American Chemical Society and Massachusetts Institute of Technology. For more information, please visit www.nesacs.org.

27 SUPPORTING DOCUMENTATION: ACTIVITY 2 -- BRAUNER MEMORIAL LECTURE from the Brauner Lecture Committee

As agreed by the Northeastern Section and the ACS, the Phyllis A. Brauner Lecture will be held in the Northeastern Section’s territory in conjunction with National Chemistry Week and named in memory of Dr. Brauner. As envisioned and established by Phyllis, and presented by the Northeastern Section since 1986, the Lecture will be for the general public of all ages. In addition to assisting with the annual presentation of the Lecture, the Committee is charged with establishing a trust that will support the Lecture. Since the Lecture is a participant in National Chemistry Week, contributions may be matched through the ACS Matching Gift Fund Program, subject to the conditions of this program and to continuing support of this program by the ACS. The endowment goal is a $140,000 endowment fund with income supporting the lectures.

The committee met regularly during 2003, including several meetings held jointly with the NCW Committee. Activities of the Committee included: organizing the 2003 Phyllis A. Brauner Lecture and associated activities; distributing a brochure, poster, and solicitation literature; soliciting funds from corporations, foundations, and individuals; maintaining contact with the ACS Treasurer’s office regarding NCW-related donations and foundation requests.

On Sunday, October 19th, the Northeastern Section and Wellesley College sponsored and hosted a daylong event as part of the NESACS 2003 National Chemistry Week celebration. Members of the Brauner Committee assisted with organization and participation in events of the day. Among the highlights of the day, Prof. Bassam Shakhashiri of U.Wisconsin-Madison gave two presentations of the Phyllis A. Brauner Memorial lecture. These captivating lectures were enjoyed by children and adults alike; photos may be viewed as part of the NESACS NCW report. Additionally, hands-on activities demonstrating the NCW theme were presented by volunteers from local colleges.

Posters related to the Brauner Lecture may be found in the previous section on NCW.

28 Invitation to Attend Lecture

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE

DR. DORIS I. LEWIS PHONE: (617) 573-8546 SUFFOLK UNIVERSITY FAX: (617) 573-8668 41 TEMPLE STREET [email protected] BOSTON, MA 02114

October 8, 2003

Dear Friend of the Phyllis A. Brauner Lecture,

I am writing on behalf of the Phyllis A. Brauner Lecture Committee to inform you of our current activities and to invite you to join us in attending and supporting this year’s Lecture. Once again the award-winning lecturer and chemical educator, Dr. Bassam Shakhashiri, will be featured. This year the site of the lecture will be Wellesley College, Phyllis’ alma mater, and the date is Sunday, October 19. The beautiful campus promises to be a wonderful setting for the Lecture and for the hands-on activities for youngsters led by area college chemistry students. Please consult the enclosed brochure for details on this marvelous day of activities, the Northeastern Section's opening activity for National Chemistry Week. The lecture is already sold out, but please contact me if you were counting on tickets, as we have held a limited number for Friends of the Lecture. If you would like to help out with the day’s activities, you’re cordially invited to do so; just contact me. You are invited as well to visit the Northeastern Section web site at www.nesacs.org to view the National Chemistry Week activities, and particularly, under the 2003 NCW link, to view the web site of the Brauner Lecture.

Additionally, I am pleased to report that the Northeastern Section has transferred $25,000 to the Phyllis A. Brauner Lecture Trust, and that personal donations, corporate matches, and ACS matching funds have brought the total at this time to over $45,000. We continue to seek individual, corporate, and foundation support toward our goal of $150,000, and are appreciative of donations or of suggestions of appropriate sponsors. Under current American Chemical Society guidelines, donations of $3000 or more paid over a period of three years or less are eligible for a match on a 50% basis. Establishing the Brauner Trust as a Northeastern Section Trust has ensured the continuation of the Phyllis A. Brauner Lecture, a lasting memorial to Phyllis, bringing the excitement of chemistry to the public of all ages.

Sincerely yours,

Doris I. Lewis, Chair Phyllis A. Brauner Memorial Lecture Committee [email protected] 617-573-8546

Phyllis A. Brauner Memorial Lecture Committee Inka Allen Michaelene Chen Sarah Iacobucci Katherine O’Sullivan Steven Allen Dudley Hershbach Ann Jenkins Bassam Shakhashiri Catherine Brauner Arno Heyn Doris I. Lewis Carolyn Spodick Susan Brauner Esther A. H. Hopkins Julianna Lovell Valerie Wilcox

29 Sample request for Funding - Foundations

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

JOHN L. NEUMEYER SECTION OFFICE MCLEAN HOSPITAL / ADARC 23 COTTAGE STREET HARVARD MEDICAL SCHOOL NATICK, MA 01760 115 MILL STREET PHONE OR FAX: (508) 653-6329 BELMONT, MA 02478 MA & NH ONLY: (800) 872-2054 [email protected] E-MAIL: [email protected]

July 25, 2003

American Honda Foundation P. O. Box 2205 Torrance, CA 90509-2205

Dear Sir or Madam:

Re: Proposal for Funding – Phyllis A. Brauner Memorial Lecture Fund

On behalf of the Phyllis A. Brauner Memorial Lecture Fund Committee I am pleased to enclose a proposal for the Directors’ consideration in the next round of funding.

The Brauner Lecture is the first endowed activity by the Northeastern Section of the American Chemical Society named for a woman. Dr. Brauner exemplified the leadership qualities in her field of education, bringing the appreciation of science to the public in general, and school children in particular.

The Lecture, a chemistry lecture-demonstration, is an innovative public educational program that works and is aimed at the K-12 age group. It supports teachers (and parents) in presenting demonstrations to be used in their classrooms. It motivates students to reach their full potential through interest in science, especially chemistry, and encourages them to continue to college and graduate school.

We are requesting $25,000 from the American Honda Foundation toward our Endowment Fund (the contribution may be matched by the American Chemical Society). We will be most appreciative, however, of any amount the Directors feel is appropriate.

Please do not hesitate to contact us with any questions.

Sincerely yours,

John L. Neumeyer Chair, 2003

Enclosure cc: Doris Lewis, Susan Brauner

30 From the Minutes of the Long-Range Planning Meeting:

The Brauner Fund (Doris Lewis): The Board met to set up the fund; minutes will come later. Donation into income fund until 2005. Account has been opened and money already transferred. Members of the Brauner committee are still pursuing corporate donations. Honda wants details and 5-year plan.

Example of NCW Press Release related to the Phyllis A. Brauner Memorial Lecture:

Earth’s Atmosphere and Beyond: How the Northeastern Section of the American Chemical Society (NESACS) combined National Chemistry Week (NCW) Activities with a tour of Wellesley College’s Greenhouses to Excite Young Minds about Science. Many of you are asking yourselves, what does National Chemistry Week have to do with Botany, Horticulture or the Greenhouses for that matter? The week of October 19-25, 2003 was designated National Chemistry Week by the American Chemical Society. Local chemistry communities all over this country used this as an opportunity to capture the curiosity of young minds and to invigorate young people, of the wonders and benefits of science. The NESACS kicked off NCW with an entire day, October 19th 2003, of fun yet stimulating science experiments for kids of all ages to explore at Wellesley College. The day’s events/activities included the following: 1) A variety of hands-on discovery experiments related to the theme “Earth’s Atmosphere and Beyond”. 2) Two showings of the Phyllis A. Brauner Memorial Lecture, by “Magic Show” Chemistry Professor Bassam Shakhashiri. 3) A visit to Wellesley College’s Greenhouses.

These activities represented a wonderful synergy of the Sciences, in particular Chemistry and Biology. The chemical experiments involved such things as making your own humidity testers, make your own UV Light sensitive bracelets and making a Cloud from a demonstration kit. The gases generated by many of the experiments are directly related to those generated and or used by the plants of the greenhouses and provided the kids with concrete applications of the interdependency of earth’s atmosphere to what we do and how we live. For example hands on experiments where kids generated carbon dioxide from reactions of typical household items, such as vinegar and baking soda, (to the chemists, acetic acid and sodium hydrogen carbonate). The kids visit to the greenhouses enabled them to experienced and (saw) that plants use carbon dioxide to generate oxygen.

Interdependency was also represented by the human connections; for example, Mary Coyne, Professor Emerita of biology, and her grandson participated in the hands-on chemistry demonstrations, (see picture) to generate carbon dioxide, attended the Chemistry Magic Show where Professor Shakhashiri “fog-up” the room by generated more gaseous carbon dioxide from dry-ice. In addition to those experiments the children also made paper planes and learn through experimentation the relationship between materials from which the paper is made and the ability of their paper planes to ‘fly”.

Despite dreary New England weather, cold and overcast; over 400 kids of all ages; grandparents, parents and their children participated in the numerous NCW experiments attended the lecture-demonstration and visited the greenhouses on October 19th. While not all were able to experience the wonders of sunlight in making their UV Light sensitive bracelet, they did have direct application in the testing of their Humidity Tester. The organizing committee of NESACS National Chemistry Week is please that we were able to extent the learning about Earth’s Atmosphere by incorporating visits to the Wellesley College’s greenhouses.

31 SUPPORTING DOCUMENTATION: ACTIVITY 3 -- GERMAN EXCHANGE from the YCC report:

During the week of February 23, 2003, twelve graduate and undergraduate students from the Boston area traveled to Germany to participate in the 3rd annual NESACS-YCC/GDCh-JCF Exchange Program. The Gesellschaft Deutscher Chemiker (GDCh)-Jungchemikerforum (JCF) (German Chemical Society Younger Chemists Committee) graciously hosted our students for the second year in a row in order to celebrate Germany’s “Year of Chemistry.”

The Boston-area students who participated were selected based on their accomplishments in research, their interests, and a recommendation from their advisors. The steering committee, consisting of Dr. Amy Tapper, Dr. Michael Strem, Dr. Ruth Tanner, and Dr. Morton Hoffmann, helped to coordinate the exchange and select the students. Four of the students gave oral presentations at the Euregionale student research conference in Dresden. The remaining students presented posters. They represented the Northeastern Section well and were nominated in three of the four possible award categories at the Euregionale. A report was written by two of the participating students and was published in The Nucleus (the NESACS monthly newsletter). The article, as well as photographs and programs, can be found on our new website under “German Exchange 2003.”

The program was particularly successful this year in that it inspired one of the participating students, Jarred Blank of Boston College, to apply for a postdoctoral fellowship. Jarred was selected for the Alexander von Humboldt Fellowship and will begin his study in Muelheim, Germany at the Max-Planck- Institute in March 2004.

(Additional details are available in Appendix 6 -- Report of the Younger Chemists Committee)

32 SUPPORTING DOCUMENTATION: ACTIVITY 4 -- STUDENT RESEARCH from the Education Committee report

The Northeast Student Chemistry Research Conference

Held at Boston University on April 26, 2003, the Research Conference brings together undergraduates, graduates students and postdoctoral fellows from the northeastern region of the country for the purpose of celebrating their accomplishments in research, and to provide a forum for the sharing of ideas and scientific understanding. The Symposium featured poster presentations by undergraduate and graduate students from area colleges and universities. The keynote address, Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things, was given by Dr. Charles Lieber of Harvard University.

In addition to the poster presentations, there were six student presentations: three undergraduate student speakers and three graduate student speakers. from the YCC ChemLuminary Self-Nomination

The Northeast Student Chemistry Research Conference (NSCRC) 2003 subcommittee also saw its largest, most diverse membership since the start of the conference in 1999. The conference itself, held on April 26, 2003 at Boston University, also boasted a large, diverse participation (approximately 80 attendees). For the first time, the NSYCC was able to award poster and oral presentations this year, giving winners free on-line journal subscriptions donated by the ACS.

The complete NSCRC Program may be found in Appendix 5-A of the NESACS Annual Report.

The Second Undergraduate Environmental Research Symposium.

On Saturday, November 15, 2003, The Second Annual Undergraduate Environmental Research Symposium was held in the John Joseph Moakley Center at Bridgewater State College. The Symposium featured 33 poster presentations from 53 student presenters. Over 100 students, faculty and mentors were in attendance. The formal program began with the keynote address by Berkeley W. Cue, Jr., Ph.D., Vice President, Pfizer Global Research and Development. The title of Dr. Cue’s presentation was, “Green and Sustainable Chemistry – A Perspective From Pfizer”.

Dr. Cue’s talk was perfectly geared for undergraduates from all disciplines, and his open personality made him very approachable to all attendees. Two poster sessions were held immediately following Dr. Cue’s talk in which 66 posters were presented. Attendees were treated to a continental breakfast, and to lunch.

Assistance with registration and poster set-up was provided by the Bridgewater State College ACS Student Affiliate. In addition to NESACS, financial assistance was provided by the Bridgewater State College Adrian Tinsley Program for Undergraduate Research and by the NCUR/Lancy Initiative, a program that provides resources to undergraduates who show promise of exceptional achievement.

James Flack Norris/Theodore William Richards Undergraduate Summer Research Scholarships.

Awards of $3250 each (including $500 for support of the research) were presented in May to four undergraduates from among 18 well-qualified applicants. The 2003 recipients were:

33 · Pasha Mirazimi, Boston College, Development of Models for the Dynamics of Oligomeric DNA through Solid State Nanopore Channels; Prof. Udayan Mohanty, Advisor · Travis R. Pribusauskas, Bridgewater State College, Synthesis of Solvated Molybdenum Clusters from Molybdate; Dr. Steven Haefner, Advisor · Rozalina Grubina, Harvard University; Assembly of a Cyclic Small Molecule Library Using DNA- Templated Synthesis; Prof. David R. Liu, Advisor · Kristin M. Felice, Stonehill College; Modeling the Zn2+ Coordination Sites of Zinc Metalloenzyme Using Peptide Phage Display; Prof. Marilena Hall, Advisor

The competition was publicized through The Nucleus, the NESACS Web site, and mailings of applications and descriptive material to the chairs of the Departments of Chemistry, Biochemistry, and Chemical Engineering at colleges and universities in the Section. Applications included student transcripts, descriptions of the proposed research, and two letters of recommendation. The awards enabled the students to spend the summer of 2001 engaged in research at their home institutions. The awardees were required to provide reports for publication in The Nucleus by November 7, 2003 and to submit papers for the Annual Undergraduate Research Symposium in April 2004 at Boston University.

Grants -in -Aid to Undergraduates

The Education Committee has awarded Grants-in-Aid of $250 each to eight undergraduates at colleges and universities within the Northeastern Section to enable them to attend the ACS National Meeting in Anaheim, California to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education on Monday, March 29, 2004. Matching funds have been committed by the institutions to support the students’ travel.

Applications for the travel stipend are accepted from students majoring in chemistry, biochemistry, chemical engineering, or molecular biology majors who are in good standing with at least junior status, and are currently engaged in undergraduate research.

34 SUPPORTING DOCUMENTATION: ACTIVITY 5 -- CONNECTIONS TO CHEMISTRY from the Education Committee report

On October 8, 2003 NESACS sponsored Connections to Chemistry, a unique program to connect high school chemistry teachers to the educational resources of the ACS and to the members of the Northeastern Section. The program, hosted by Burlington (MA) High School, drew over 140 teachers from 84 different high schools in all six New England states.

The following afternoon workshops were offered to showcase the ACS resources for high school chemistry teachers and students:

Workshop A: Performing Effective Chemical Demonstrations John Mauch, Braintree High School and Chair of the High School Committee, ACS Division of Chemical Education with Linda Weber, Natick High School

Workshop B: Liability in the Laboratory and Classroom Attorney Sarah Gibson, sponsored by the Massachusetts Teachers Association

Workshop C: NCW, Will a Match Burn in the Absence of Gravity? Thomas Gilbert, Associate Professor of Chemistry and Education, Northeastern University

Workshop D: Exploring Quantum Concepts in Chemistry Alan Crosby and Associates, Department of Chemistry; and Peter Garik, School of Education, Boston University (A two session workshop, 4:30 - 6:10)

The evening program included dinner and a talk by Ms. Sally Mitchell, the recipient of the Northeast Regional ACS Outstanding High School Teacher Award. Her address was titled Around the World on 37 Cents! Or How to Find Unusual Resources for Teaching

The Connections program received substantial material assistance from the ACS, and the editorial staff of the Journal of Chemical Education. Publicity support was received from the New England Association of Chemistry Teachers, the Massachusetts Association of Science Supervisors, the Massachusetts Association of Science Teachers, Science Teachers Area Resources Swap and the New England Science Teachers.

The complete Connections to Chemistry program may be found in Appendix 5-A of the ACS Annual Report

35 SUPPORTING DOCUMENTATION: ACTIVITY 6 -- BUDGET & FINANCE COMMITTEE

From the Minutes of the Long-Range Planning Meeting:

NESACS Finances Jim Piper did 10-year overview of the section's finances: Overall the trend is upwards for both income and expenditure, expenses running high. Meal costs doubled in 2002, and we are near the ceiling of money taken from the trust funds!

· Increase user fees for activities (such as Ashdown) · Increase price charge for Red Socks tickets · Apply for ACS-Mini Grants-Search the ACS-web site for ideas · Look for Corporate sponsor of specific projects, such as Project SEED and High School Teachers from the Corporate Funding Committee Report:

Committee met four times during the year. The members, Jim Quick (Chair), Mike Strem, Amy Tapper and David Yesair, felt that all approaches to corporations for donations to support the section's activities should go through the Committee. New solicitations should be tailored to the support of specific activities if possible. We also changed the names and the limits of the support levels. For gifts of $2,000 or greater they will be listed as a Benefactor while gifts of $1,000 or $500 will be acknowledged as a Corporate Patron or Corporate Sponsor respectively.

Complete details related to Corporate Funding may be found in Appendix 5.

36 SUPPORTING DOCUMENTATION: ACTIVITY 7 -- WELCOME & SURVEY OF NEW MEMBERS

Please see Appendix 3 -- 3-A for copies of · Section Chair's welcoming letter to new NESACS members · Copy of survey form sent to new members · Tabulation of survey results

In addition, a welcoming letter from the chair of the Membership Committee is sent monthly to new members inviting them to attend a Section meeting and dinner as a guest of NESACS. A copy of this letter may be found in Appendix 5--Report of the Membership Committee.

37 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 2

BUDGETS LONG-RANGE PLAN

http://www.nesacs.org

38 APPENDIX 2 - BUDGETS AND LONG-RANGE PLAN

APPENDIX 2

REPORT OF THE TREASURER - 2003

Page 1 of the financial report reflects the transactions in the operating account of the Section. In addition to the operating account, the Trust Funds operate under the supervision of the Board of Trustees. The operating account generally pays all bills and then requests reimbursement of Trust-related expenses from the Trustees. In 2003, those reimbursements totaled $68,991.75 (included in line 10). Since the Trust funds are separately maintained, the calculation of the Public Support ratio on page 2 of the Financial Report is incorrect. The correct calculation is on the attachment to the Financial Report.

The Finance Committee established in 2002 met three times to discuss various aspects of the Section’s finances, including the impact of a Transfer of Funds to establish the Brauner Trust. The Committee also examined the increasing draw on Trust Funds by the Operating Account, but made no recommendations.

The Attorney General of the Commonwealth of Massachusetts requires public charities to file annual reports, and organizations with gross revenue exceeding $250,000 are required to submit audited financial statements. The audited statements for 2002 are still in the process of being completed.

James U. Piper Treasurer

39 2-A: Budgets BUDGET 2003

Northeastern Section 01/07/03 Budget Proposal 2002 2002 2003 2003 2003 Annual Account # Budget Actual Requests Proposed Proposed From General Offsetting Acct National Allotment 10 25,601.00 25,601.00 26,841.00 Travel Grants 11 7,500.00 8,661.25 12,000.00 Local Dues 12 40,700.00 42,197.82 42,000.00 New-member Commission 13 50.00 0.00 50.00 Contributions 14 5,000.00 10,110.00 8,000.00 Other Program Income 15 800.00 610.00 2,300.00 Project SEED 16 1,350.00 1,750.00 6,000.00 Continuing Education 17 2,000.00 28,075.00 2,000.00 2,000.00 Dinner Receipts 18 5,000.00 8,064.00 7,000.00 Savings Interest 19 1,000.00 165.72 150.00 Miscellaneous 20 0.00 3,992.50 Trustees: Cons. Acct. 21 1,000.00 592.90 1,000.00 Perm. Inc. Acct. 22 19,301.00 23,964.06 10,750.00 Norris Inc. Acct. 23 20,350.00 23,877.36 23,000.00 Richards Inc. Acct. 24 19,300.00 12,900.63 8,850.00 Publ. Inc. Acct. 25 6,000.00 3,822.00 13,000.00 Hill Award 26 1,500.00 1,224.66 1,500.00 Esselen Award 27 14,000.00 15,858.15 14,000.00 Levins Award 28 700.00 677.93 700.00 NERM 29 0.00 12,884.00 Summer Programs 30 1,000.00 9,204.00 2,500.00 2,000.00 Advertising 31 50,400.00 54,095.50 46,000.00 INCOME TOTALS 222,552.00 288,328.48 81,541.00 150,100.00 TOTAL 231,641.00 Chair 50 3,000.00 3,026.64 3,900.00 3,315.00 Business Office 51 1,800.00 2,063.13 1,800.00 1,800.00 Treasurer 52 5,700.00 6,184.83 5,650.00 722.50 4,800.00 Archivist 53 200.00 0.00 200.00 100.00 Publication, Web Site 54 1,000.00 843.09 5,000.00 Nucleus 55 70,727.00 70,365.13 64,990.00 10,990.00 54,000.00 see notes Program 56 1,500.00 982.02 3,000.00 2,125.00 Ballots 57 1,750.00 1,725.04 1,750.00 Public Relations 58 1,000.00 738.31 1,750.00 750.00 Prof. Relations 59 500.00 0.00 1,000.00 850.00 Education 60 8,950.00 9,249.17 10,250.00 8,712.50 1,000.00 Newell Awards 61 1,000.00 954.72 700.00 700.00 Ashdown Awards 62 2,000.00 2,413.98 2,000.00 1,020.00 800.00 Continuing Education 63 2,000.00 21,143.17 2,000.00 2,000.00 Local Arrangements 64 6,500.00 20,600.26 8,000.00 7,000.00 New & 50 Yr members 65 500.00 630.80 600.00 Membership Committee 66 800.00 657.87 1,000.00 1,000.00 Hill Award 67 1,500.00 1,299.12 1,500.00 Norris Award 68 12,000.00 16,003.41 16,000.00 16,000.00 Speakers Bureau 69 150.00 0.00 150.00 150.00 Summer Scholars 70 13,700.00 12,471.40 13,700.00 13,700.00 23,24 Project SEED 71 4,450.00 3,562.37 14,000.00 6,000.00 6,000.00 Richards Medal 72 12,000.00 7,836.87 Esselen Award 73 14,000.00 14,901.21 14,000.00 14,000.00 Levins Prize 74 700.00 626.16 700.00 Sec. School Award 75 1,800.00 2,039.48 2,000.00 Aula Laudis 76 375.00 546.06 550.00 550.00 Trustees 77 1,000.00 591.32 1,000.00 1,000.00 Safety Committee 78 0.00 0.00 Chair-elect 79 650.00 274.68 2,300.00 1,955.00 Legislative Affairs 80 500.00 0.00

40 Student Safety Training 81 8,226.00 0.00 delete line National Chem. Week 82 7,000.00 6,370.35 4,250.00 2,000.00 Summer Programs 83 1,000.00 9,144.67 2,000.00 ACS Scholars 84 2,700.00 2,624.00 2,700.00 2,700.00 Medicinal Group 85 6,500.00 7,247.69 9,000.00 7,500.00 Travel Grants 86 11,000.00 12,897.70 6,000.00 12,000.00 Adm. Secretary 87 20,000.00 16,237.50 20,000.00 18,000.00 Miscellaneous 88 0.00 498.23 NERM/Nat'l Meeting 89 500.00 13,320.97 100.00 Younger Chemists Comm 90 4,800.00 6,606.41 5,800.00 3,580.00 500.00 SAPA 91 500.00 0.00 0.00 Jung Chemiker 92 15,000.00 14,918.81 20,000.00 7,000.00 EXPENSE TOTALS 248,978.00 291,596.57 96,120.00 150,100.00 TOTAL 246,220.00

41 BUDGET 2004

Northeastern Section 01/02/04 draft Budget Proposal 2003 2003 2004 2004 2004 Annual Account # Budget Actual Requests Proposed Proposed From General Offsetting Acct National Allotment 10 26,841.00 26,841.00 29,195.00 Travel Grants 11 12,000.00 13,677.30 12,000.00 Local Dues 12 42,000.00 41,985.97 42,000.00 New-member Commission 13 50.00 45.00 50.00 Contributions 14 8,000.00 11,769.00 22,000.00 9,000.00 Other Program Income 15 2,300.00 2,765.00 8,775.00 Project SEED 16 6,000.00 2,425.00 6,000.00 Continuing Education 17 4,000.00 19,575.00 2,000.00 8,000.00 Dinner Receipts 18 7,000.00 9,529.00 7,000.00 Savings Interest 19 150.00 77.78 100.00 Miscellaneous 20 0.00 3,708.00 Trustees: Cons. Acct. 21 1,000.00 0.00 1,000.00 Perm. Inc. Acct. 22 10,750.00 3,029.00 9,000.00 Norris Inc. Acct. 23 23,000.00 29,524.87 30,100.00 Richards Inc. Acct. 24 8,850.00 16,437.88 14,000.00 Publ. Inc. Acct. 25 13,000.00 4,000.00 8,000.00 Hill Award 26 1,500.00 4,000.00 1,500.00 Esselen Award 27 14,000.00 12,000.00 14,000.00 Levins Award 28 700.00 0.00 700.00 Brauner Lecture 29 2,000.00 NERM 30 0.00 8,800.00 Summer Programs 31 4,500.00 13,036.00 500.00 2,000.00 Advertising 32 46,000.00 49,143.00 50,000.00 50,000.00 INCOME TOTALS 231,641.00 272,368.80 95,845.00 183,075.00 TOTAL 278,920.00 Chair 50 3,315.00 2,791.65 4,100.00 4,100.00 Business Office 51 1,800.00 1,866.04 1,850.00 Treasurer 52 5,522.50 790.46 5,600.00 800.00 4,800.00 22 Archivist 53 100.00 90.46 400.00 400.00 Publication, Web Site 54 5,000.00 0.00 Nucleus 55 64,990.00 66,808.04 69,480.00 11,480.00 58,000.00 see notes Program 56 2,125.00 1,014.21 1,000.00 1,000.00 Ballots 57 1,750.00 1,847.97 1,850.00 Public Relations 58 750.00 593.79 750.00 Prof. Relations 59 850.00 0.00 1,200.00 1,200.00 Education 60 9,712.50 9,922.62 15,000.00 11,825.00 3,175.00 15 Newell Awards 61 700.00 1,029.00 1,000.00 1,000.00 22 Ashdown Awards 62 1,820.00 2,428.52 2,500.00 1,900.00 600.00 15 Continuing Education 63 2,000.00 17,116.54 8,000.00 8,000.00 17 Local Arrangements 64 15,000.00 19,519.01 8,600.00 7,000.00 18 New & 50 Yr members 65 600.00 70.00 Membership Committee 66 1,000.00 423.66 1,000.00 1,000.00 Hill Award 67 1,500.00 4,045.71 1,500.00 26 Norris Award 68 16,000.00 13,945.30 16,000.00 23 Speakers Bureau 69 150.00 32.52 400.00 400.00 23 Summer Scholars 70 13,700.00 15,494.15 13,700.00 13,700.00 23 Project SEED 71 12,000.00 4,811.11 6,000.00 6,000.00 16 Richards Medal 72 0.00 88.50 12,000.00 24 Esselen Award 73 14,000.00 13,119.07 14,000.00 27 Levins Prize 74 700.00 640.00 700.00 28 Sec. School Award 75 2,000.00 2,178.65 2,000.00 24 Aula Laudis 76 550.00 695.17 500.00 500.00 22 Trustees 77 1,000.00 628.89 1,000.00 21 Safety Committee 78 0.00 0.00 Chair-elect 79 1,955.00 512.10 2,700.00 2,700.00 Legislative Affairs 80 0.00 0.00

42 National Chem. Week 81 6,250.00 5,049.90 6,650.00 4,650.00 2,000.00 29 Summer Programs 82 2,000.00 12,715.36 2,000.00 31 ACS Scholars 83 2,700.00 2,500.00 2,500.00 2,700.00 22 Medicinal Group 84 7,500.00 3,430.53 7,500.00 7,500.00 Travel Grants 85 18,000.00 19,759.04 6,000.00 12,000.00 11 Adm. Secretary 86 18,000.00 15,882.26 Inc1 to $27 18,000.00 Miscellaneous 87 0.00 121.00 NERM 88 100.00 0.00 100.00 Younger Chemists Comm 89 4,080.00 3,201.73 9,600.00 4,600.00 5,000.00 15 Jung Chemiker 90 7,000.00 7,754.60 21,000.00 12,000.00 9,000.00 14 EXPENSE TOTALS 246,220.00 252,917.56 108,305.00 183,075.00 TOTAL 291,380.00

43 APPENDIX 2

LONG-RANGE PLAN

Long-Range Planning Meeting June 9, 2003 -- 5:00 p.m. - 7:00 p.m. McLean Hospital, Belmont

Minutes of the Meeting

Board members, Committee members and Section members in attendance: John Neumeyer, Tim Frigo, Patrick Gordon, Jean Fuller-Stanley, Michaeline Chen, Arno Heyn, Don Rickter, Mary Burgess, Wallace Gleekman, Doris Lewis, Arlene Wick Light, Truman Light, Ruth Tanner, Amy Tapper, Morton Hoffman, Alfred Viola, Jim Piper, Pamela Nagafuji

The meeting was called to order at 5:00 p.m. with J. Neumeyer in the Chair.

Discussion started with announcement of the recent local section election results. Due to increased membership in the Northeastern Section, National ACS has increased the number of Councilors from 12 to 14 and also the number of alternate councilors from 12 to 14. It was decided at the May monthly meeting that the runner-up candidates would be utilized to fill the extra councilor/alternate councilor slot in the 2003-2005 term. M. Singer’s memo summarized the following changes to the councilor-alternate councilor roster:

T. Light to Councilor 2003-2005 from alternate councilor 2002-2004 D. Rickter to Alternate 2003-2005 from alternate councilor 2002-2004 L. Scott to Alternate 2003-2005 from alternate councilor 2002-2004 M. Chorghade to Alternate 2002-2004 from runner-up 2002 election cycle D. Warr to Alternate 2002-2004 from runner-up 2002 election cycle.

The 2003 election results caused only one shift. M. Chen won a councilor position for 2004-2006 which is an upgrade from the alternate councilor 2003-2005 term. This leaves one vacancy in the alternate councilor 2003-2005 roster, There are no more available runner-up candidates from the 2002 or 2001 election cycle; I recommend that the vacancy in alternate councilor 2003-2005 be filled by Lowell Hall.

· Increase user fees for activities (such as Ashdown) · Increase price charge for Red Sox tickets · Apply for ACS-Mini Grants-Search the ACS-web site for ideas · Look for Corporate sponsor of specific projects, such as Project SEED and High School Teachers

Some suggestions: Emphasize community outreach, NCW, active high school outreach, lecture at Museum of Science.

Public Relations: High School Awards Night, one of the most significant and public shows of support. These need to be widely publicized. Many questions and suggestions arose regarding publicity or lack of publicity of the above event. · Public Relations Committee -- who are the members?

44 · Were articles sent to the local newspapers of the High School Recipients? · Mukund Chorghade is supposed to be the PR Chair; has he been trained by National? · Ask Mukund if any articles were sent about the Education Night Awards · Put article in The Nucleus looking for interested PR persons! · Ask local papers to send reporters to NESACS events (unlikely) · Ask for reporters at each college/university to send weekly/monthly reports · Wally suggests sending letters to recipients' school superintendent to release to media · Send monthly meeting notice to Globe “Events Calendar”, and other newspapers. · Public Relations Issues are unresolved!!!!!!!!!!!!!

Section's Web site: Board of Publications meeting reported increased number of hits at the web site. Suggestion that the web site need to be redesigned and made snazzier--the best link is YCC (created by someone at BU, free). Need to keep website current. Many people will visit the website. Recent short course yielded five registrations from the website. Sam Kounaves maintains the website--design is separate! How long should the section archive on the site--now 2-3 years--does this cost money? Need Annual calendar for website; also monthly meeting dates should be posted.

Esseleen and Richards Awards Committees: Chairs and committee members take office immediately, not in January.

Medicinal Chemistry Group: Need to be more coordinated with the section. Pam Nagafuji has made arrangement for three speakers for a med-chem group meeting October 7th at MIT and the Professional Relations-Monthly Meeting October 9th at Wellesley College. Limited space at MIT and speakers for October 7th are not available for October 9th, thus two separate meetings will be held. The December meeting will be a joint meeting of the section and the med-chem group.

German Exchange Program: Funded from the Section. There needs to be more openness in the selection and planning. Questions were asked about how students were selected and the feasibility of limited section funds being used for this activity, worthwhile as it is.

In Mike Stern’s absence, Amy Tapper outlined how students were selected and ranked by 6 people. 12 students from 10 different schools went on this trip. Questions and suggestions were raised about alternate funding sources

· Ask National ACS for funds: National did matching funds the first year (2001) · Ask pharmaceutical and other industrial companies to fund these trips · Amy Tapper: NESACS will be hosting the German students in 2004 · To reduce cost, have NESACS members host students in their homes rather than hotels · Al Viola: cheaper venues, College Club on Commonwealth Avenue · Can NESACS expand this to other countries? · Can we afford to pay for this? Can it continue? · Ruth Tanner: There will be a meeting of the two steering committees in April 2004; we can give input then. NESACS needs to have a full discussion of this at a Board meeting in early 2004, so that input can be presented at the April joint steering committees meeting. · Doris Lewis: This is one of three ACS goals. Michaeline Chen and Cathy Costello are on the ACS International Committee.

Handbook: Material requested by Karen Piper. This will be an “operating manual”--operations of various committees and officers etc. It is 60% complete.

The ACS Handbook (Green Monster) for Local section officers is now on CD

Meeting adjourned approximately 7:15 p.m.

Notes taken courtesy of Jean Fuller-Stanley and Don Rickter

45 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 3

MEMBERSHIP SURVEYS NEWSLETTERS

http://www.nesacs.org

46 APPENDIX 3 - MEMBERSHIP SURVEY AND 2003 NEWSLETTER

3-A: Membership Survey Conducted in 2003 - Results

In addition to the welcoming letter that new members of the Northeastern Section were sent by the Chair of the Membership Committee, a letter and questionnaire were also sent by the Section Chair. The letter and questionnaire are copied below:

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

JOHN L. NEUMEYER ,PH.D. SECTION OFFICE MCLEAN HOSPITAL / ADARC 23 COTTAGE STREET HARVARD MEDICAL SCHOOL NATICK, MA 01760 115 MILL STREET PHONE OR FAX: (508) 653-6329 BELMONT, MA 02478 MA & NH ONLY: (800) 872-2054 [email protected] E-MAIL: [email protected]

Dear Colleague:

It is my pleasure to welcome you to the Northeastern Section of the American Chemical Society. Whether you are a new member of the Society or transferred to this Section, we look forward to your active participation in our varied programs which hopefully will be beneficial and professionally rewarding to you.

I would like to invite you for dinner as our guest at one of our upcoming meetings. Our meetings are generally held on the second Thursday of the month (September through May) and are published in The Nucleus, the official publication of the Northeastern Section, published monthly from January to December with the exception of July and August when there is a single Summer issue. It may be several months for you to receive The Nucleus since the mailing service in quite slow in adding new names to our mailing list. In the meantime, please check our website at www.NESACS.org for the latest announcements of our meetings. If all else fails, call the Business Manager of The Nucleus, Karen Piper, at 978-455-8622 or e-mail [email protected].

Please call our Section Secretary, Marilou Cashman, at 1-800-872-2054 or 508-653-6329 or e-mail: [email protected] for dinner reservations one week before you wish to join us for dinner. Please identify yourself as a new member.

Please call Michaeline Chen,Chair of the Membership Committee (781-235-5201) or myself if we can be of any assistance to you. We hope you will become an active member of this Section. We are always in need of volunteers to participate in the governance of this, one of the largest and most active sections of the American Chemical Society.

I am looking forward to meeting you in person and to welcome you to this Section at one of our future meetings. Please complete the brief questionnaire enclosed and return it to Marilou Cashman.

Sincerely yours,

John L.Neumeyer,Ph.D. Chair, Northeastern Section, ACS

47 MEMBERSHIP QUESTIONNAIRE

Please complete this questionnaire and return it to:

Marilou Cashman 23 Cottage Street Natick, MA 01760

Please PRINT all responses.

Name Degree

Affiliation Name and address of company or university

Contact Information where we can contact you:

Phone: E-mail:

Are you a NEW ACS member? Yes No

If "No," where did you relocate from?

Areas of interest or specialization (e.g., Organic, Medicinal, Analytical, etc.)

Are you interested in participating in one of our Section committees? Check one or more:

Awards Professional Services Publications Programming Chemical Education Public Relations Government Relations Web Site Industrial & Business Relations Younger Chemists Membership

May we publish any parts of this information in The Nucleus? Yes No

If you prefer to submit this form electronically, please contact Marilou Cashman at [email protected] and the form will be sent to you as a Word document which can be downloaded, completed, and returned via e-mail.

48 RESULTS

A total of 43 questionnaires were returned providing the Section with information that is helpful in planning activities and in recruiting assistance for specific committees. A tally of the questionnaires produced the following results:

Degrees: Ph.D. 24 J.D. 2 Master's Degree 8 Bachelor's Degree 9

Affiliations: College/University 21 High School 1 Business/Industry 20 Retired 1 Unemployed 1 Note: One respondent indicated affiliations with both a university and a business organization

Colleges/Universities named: Boston College MIT Harvard University Harvard Medical School Tufts University University of Mass. Dartmouth Boston University University of Mass. Boston College of the Holy Cross

Businesses/Industries named: Cabot Corporation Visen Medical, Inc. eMembrane, Inc. Pfizer, Inc. Sigma-RBI Aerodyne Research, Inc. Alkermes, Inc. Echo Technologies, Inc. Schepers Eye Research Institute Novartis Institutes Transform Pharmaceuticals Cohesive Technologies, Inc. Hybridon, Inc. Polaroid Corporation Applied Biosystems Amgen Parker Balston Shipley Company Finnegan Henderson Panasonic Boston Laboratory

New ACS Members 25 Relocated Members 18 Relocated from: East Lansing, MI University of Missouri, Columbia North Carolina Texas Duke University, No. Carolina

49 Florida (2) Indianapolis, IN Long Island, NY New Jersey Research Triangle Park, No. Carolina Worcester, MA Columbus, OH University of Pennsylvania, Philadelphia, PA Berkeley, CA Washington, DC

Area of Interest: Analytical Polymers Toxicology Physical Atmospheric Education Policy Patent Law Nanotechnology Bio-informatics Organic Inorganic Catalysis Materials Medicinal Biological Natural Products Biochemistry Environmental Forensic Science Ceramics Mucosal epithelia Medical Sciences Computational Biophysical Electrochemistry Protein Biochemistry Energy Sources

NESACS Committee Interests: Industrial / Business Relations Membership Awards Chemical Education Government Relations Professional Services Younger Chemists Publications Programming Web Site

Thirty-two (32) respondents indicated they would be willing to have their responses published in The Nucleus; eight (8) did not want the information published; and three (3) did not respond to this question.

Some data relating to those who responded (name/address/contact numbers) is not included in this report in order to protect the personal information about the respondents.

50 3-B: 2003 Newsletter September 2003 issue of The Nucleus uploaded into online report.

Copies of The Nucleus may be viewed in PDF format on the NESACS web site at http://www.nesacs.org

51 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 4

PUBLIC RELATIONS PLAN TALKS TO PUBLIC

http://www.nesacs.org

52 APPENDIX 4

4-A: Public Relations Plan

The following public relations activities are included in the Public Relations Plan for 2003:

Ø Provide press releases for publication in The Nucleus and area newspapers relating to all meetings of the Section Ø Make arrangements for a photographer to be present at selected meetings of the Section; i.e.,

§ April 2003 Esselen Award § May 2003 Education Awards § October 2003 Hill Award & 50-Year Member Certificates § November 2003 Norris Award

Ø Recipients of awards will be provided with copies of the pictures taken at the event. Photographs will also be printed in The Nucleus and posted on our web site.

Ø Arrange for preparation, e-mailing, and posting on web site of flyers describing monthly meetings; e-mail to approximately 200-250 chemists, colleges, and businesses in the area approximately three weeks prior to each meeting of the Section with follow-up reminder notices approximately one week prior to each meeting.

Ø Arrange for mailing, e-mailing, and posting on web site of information about Section activities relating to high school students and teachers to all high schools in the Northeastern Section's geographical area. Specifically, this includes the following: § Ashdown and Olympiad Examinations § Richards Award for Outstanding Secondary School Teaching § Lyman C. Newell Grants to attend NEACT summer conference § National Chemistry Week activities § Connections to Chemistry Program for High School Teachers § Speakers' Bureau brochure

Ø Arrange for information about Section activities relating to college students to be mailed and e-mailed to all colleges and universities in the Northeastern Section's geographical area and to be posted on the web site. Specifically, this includes the following: § Norris - Richards Undergraduate Summer Research Scholarships § Northeast Student Chemistry Research Conference (NSCRC) § National Chemistry Week activities § Undergraduate Research Poster Session Call for Papers (ACS) § Undergraduate Grants-in-Aid to attend 2004 National ACS meeting § Philip L. Levins Memorial Prize

Ø Arrange for information relating to Continuing Education programs offered by the Section to be mailed to over 500 individual chemists and chemical companies, e-mailed to approximately 200-250 chemists, published in The Nucleus and posted on the web site.

Ø All items mentioned above will be publicized in The Nucleus and posted on the web site.

Ø Press releases relating to Section activities will be written as information is provided and upon request from officers and committee chairs; these will be distributed appropriately via flyers, The Nucleus, area newspapers, Chemical & Engineering News, and area television and radio stations. In addition, information will be personally provided to journalist contacts at the Wellesley Townsman, Natick News and New England India News.

Ø In addition, Dr. Chorghade will personally deliver flyers, mention forthcoming programs and solicit participation from scientists at companies he visits on business engagements. Particular attention will be

53 devoted to recent entrants into industry and scientists who have recently relocated to the metropolitan Boston area. Other Section members will be encouraged to do likewise.

Publicity for the programs of the local Section will be enhanced by targeted mailings to the practicing chemists at the biotechnology companies in the area. We have secured contacts via the Massachusetts Biotechnology Council at several biotechnology companies in the area. A personal letter will be sent to chemists in these companies soliciting participation in the Section's activities.

54 APPENDIX 4-B: TALKS TO PUBLIC

Date Speaker/Affiliation - Title/Topic Location

10-Jan Dr. Carl Selavka / Mass. State Police Crime Lab Tufts University Why Forensic Science is Sexy; and Why You Shouldn't Trust CSI 4-Feb Prof. Christopher Arumainayagan / Wellesley College Tufts University Electron-Induced Reactions in Nanoscale Thin Films 4-Feb Dr. Guy Crosby / Private Consultant, Food/Nutrition Chemistry Univ, of New Hampshire Recent Developments in the Chemistry of Nutrition and Their Impact on Human Health 11-Feb Prof. Peter Seeberger / MIT Boston College Automated Oligosaccharide Synthesis Drives Chemical Glycomics: from Carbohydrate Arrays to a Malaria Vaccine 11-Feb Prof. James McKnight / Boston University Tufts University Cross-Examining a Villin: Structure, Function and Folding of a Small F-Actin-Binding Domain 13-Feb Melissa Huang Holiday Inn, Newton YCC Symposium: Alternative Careers for Chemists 24-Feb Prof. Keith Nelson / MIT Boston University Terahertz Polaritonics: Coherent Spectroscopy and Coherent Control 25-Feb Dr. Russell Petter / Biogen, Inc. Tufts University Remarkably Potent Antagonists of Integrin VLA-4 26-Feb Peter Tsang / MIT, Schrock Research Group MIT Inorganic Chemistry Seminar March Dr. Mukund Chorghade / Chorghade Enterprises Baltimore, MD Section Managing an Effective Job Search March Philip S. Baran / Harvard ACS/ORG Div. Award Address: Nobel Laureate Signature Award New Orleans for Graduate Education in Chemistry March William S. Hancock ACS/Analytical Div. Award Address: ACS Award in Chromatography New Orleans March Christopher T. Walsh ACS/ORG Div. Award Address: Alfred Bader Award in Bioinorganic New Orleans or Bioorgenic Chemistry 4-Mar Prof. Barry Karger / Northeastern University Tufts University New Technologies for Genomics and Proteomics Based on High Resolution Electrophoresis and Chromatography 5-Mar Prof. Roy Planalp / University of New Hampshire MIT Inorganic Seminar Series 6-Mar Prof. Amir Hoveyda / Boston College MIT Organic Syntheses, Inc. Lecture 13-Mar Dr. Susan Evans DoubleTree Hotel, Waltham Microfluidics Technology: Lab-on-a-chip" April Dr. Mukund Chorghade / Chorghade Enterprises Univ. of New Hampshire Conducting a Job Search 24-Apr Prof. Sanjeev Mukerjee / Northeastern University Northeastern University Improving Charge Transfer at Electrochemical Intervaced: An Electrochemist's Perspective on the Shape of a More Portable World 28-Apr Prof. Peter Seeberger / MIT MIT Automated Synthesis of Oligosaccharides: From Carbohydrate Arrays to a Malaria Vaccine 5-May Prof. Chris Walsh / Harvard Medical School MIT Glycosyl Transferases in Antibiotic Maturation 8-May Dr. Guy Crosby / Private Consultant, Food/Nutrition Chemistry Boston University Recent Developments in the Chemistry of Nutrition and Their Impact on Human Health 12-May Prof. Amir Hoveyda / Boston College Brandeis University New Catalytic Asymmetric Methods for Enantioselective Synthesis and their Applications to Natural Product Synthesis

55 12-May Prof. David Liu / Harvard University MIT Expanding the Scope of Molecular Evolution: Synthetic Molecules, Nucleic Acids, and Proteins 22-May Prof. John L. Neumeyer / McLean Hosp.-Harvard Med. School Northeastern University Dopamine Receptors in the Central Nervous System, Targets for Medicinal Chemists--Past, Present and Future 15-18 June Jack Szostak / Mass. General Hospital Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Thomas Pochapsky / Brandeis University Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Francesco Stellacci / MIT Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Tao Deng / MIT Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Deli Wang / Harvard University Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Martin Polz / MIT Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Michael Hearn / Wellesley College Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Gary Weisman / University of New Hampshire Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Glen Miller / University of New Hampshire Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June John Porco / Boston University Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Li Deng / Brandeis University Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Timothy Jamison / MIT Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 15-18 June Morton Hoffman / Boston University Saratoga Springs, NY Presenter: Northeast Regional Meeting, ACS 4-7 Aug. Dr. Guy Crosby / Private Consultant, Food/Nutrition Chemistry Sacred Heart Univ. You Are What You Eat Fairfield, CT September Peter H. Seeberger / MIT ACS/ORG Div./New York Award Address: Arthur C. Cope Young Scholar Award September Dietmar Seyferth / MIT ACS/ORG Div./New York Award Address: Arthur C. Cope Senior Scholar Award September Dr. Mukund Chorghade / Chorghade Enterprises ACS/New York Finding Jobs in the Biotechnology Sector September Dr. Mukund Chorghade / Chorghade Enterprises ACS/New York Overcoming Cultural and Linguistic Barriers in the Workplace 5-Sep Prof. E. J. Corey / Harvard University MIT Symposium: Genomics Institute of the Novartis Research Foundation 5-Sep Prof. Eric N. Jacobsen / Harvard University MIT Symposium: Genomics Institute of the Novartis Research Foundation 1-Oct Prof. Graham Jones Northeastern University Organic Synthesis in the Chemical Biology Interface 2-Oct Prof. Rosina Georgiadis / Boston University Harvard University Physical Chemistry 7-Oct John Talley / Microbia MIT Faculty Club The Discovery of Celebrex 8-Oct John Mauch / Braintree High School Burlington High School Performing Effective Chemical Demonstrations 8-Oct Linda Weber / Natick High School Burlington High School Performing Effective Chemical Demonstrations 8-Oct Prof. Tom Gilbert / Northeastern University Burlington High School Will a Match Burn in the Absence of Gravity? 8-Oct Alan Crosby / Boston University Burlington High School Exploring Quantum Concepts in Chemistry 8-Oct Peter Garik / Boston University Burlington High School Exploring Quantum Concepts in Chemistry

56 8-Oct Prof. Patricia A. Mabrouk / Northeastern University Northeastern University From Protein Electrochemistry to Supercritical Materials 9-Oct Dr. David W. Yesair / BioMolecular Products Wellesley College Club Creating a New Biomolecular Enterprise 19-Oct Luisa T. Molina / MIT Wellesley College Symposium: What's New in the Air? Atmospheric Chemistry in the 21st Century 19-Oct Dr. Charles E. Kolb / Aerodyne Research Wellesley College Symposium: What's New in the Air? Atmospheric Chemistry in the 21st Century 19-Oct Mario J. Molina / MIT Wellesley College Improving Air Quality in Megacities: Mexico City Case Study 19-Oct James G. Anderson / Harvard University Wellesley College Spectroscopy and Climate Change: Benchmark Observations and Forecast Testing 20-Oct Prof. Susan Lindquist / MIT Biology Dept. MIT Biochemistry Seminar Series 21-Oct Prof. David A. Weitz / Harvard University MIT Jamming and the Glass Transition 23-Oct Prof. Mario Molina / MIT MIT Symposium: Earth's Atmosphere and Beyond 23-Oct Prof. James Anderson MIT Symposium: Earth's Atmosphere and Beyond 30-Oct--2 Nov Prof. Jean A. Fuller-Stanley New Radisson Hotel Annual Compact for Faculty Diversity / Southern Reg. Educ. Board Miami, FL The Role of Professional Societies in Student & Faculty Development 1-Nov Prof. Thomas Pochapsky / Brandeis University Boston University Metalloproteins and Metalloenzymes 1-Nov Prof. Thomas Pochapsky / Brandeis University Boston University Metalloproteins and Metalloenzymes 1-Nov Prof. Sarah E. O'Connor / MIT Boston University The Biosynthesis of Natural Products 1-Nov Dr. Scot Pounds / Perkin-Elmer Boston University Shortening the Pipeline: Bringing Drugs to Market When Time Is Money 1-Nov Prof. Alex Golger / Boston University Boston University Demonstrations in Chemistry to Fascinate Kids 1-Nov Prof. Scott Schaus / Boston University Boston University Choosing a Graduate School 1-Nov Dr. Frank Wagner / Strem Chemicals, Inc. Boston University Preparing Your Resume' 1-Nov Prof. Sean Elliott / Boston University Boston University Moving Electrons through Proteins 1-Nov Dr. Aaron Beeler / Boston University Boston University Parallel Synthesis and Chemical Library Development 1-Nov Prof. Anthony Fernandez / Merrimack College Boston University Resuscitating a Shallow-Breathing Student Affiliates Chapter 3-Nov Prof. Amir Hoveyda / Boston College Brandeis University New Catalytic Asymmetric Methods for Enantioselective Synthesis and their Applications to Natural Product Synthesis 13-Nov Prof. Robert Langer / MIT University of Mass. Lowell Polymers for Drug Delivery and Tissue Engineering 17-Nov Prof. Amir Hoveyda / Boston College Abbott Bioresearch Center Practical Catalytic Enantioselective Synthesis Worcester, MA 2-Dec Prof. Li Deng / Brandeis University Boston College Catalytic Asymmetric Reactions with Modified Cinchona Alkaloids 5-Dec Dr. Paula Hammond / MIT University of Mass. Lowell Symposium: Sukant Tripathy Memorial Symposium 11-Dec Dr. Andre Rosowsky / Dana Farber Cancer Inst. Radisson Hotel / Woburn History of the Development of PT523, A Potent Folate Antagonist Recently Approved for Clinical Trial

57 11-Dec Dr. Julian Adams / Infinity Pharmaceuticals Radisson Hotel / Woburn Proteasome Inhibitors: Discovery and Development of Velcad™ (Bortezomib, PS-341) 15-Dec Prof. Yoshito Kishi / Harvard University Harvard University Lessons from Natural Product Chemistry

58 4-C: Example of NCW Press Release

59 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5

AS NEEDED BY SECTION NESACS REPORTS

http://www.nesacs.org

60 APPENDIX 5 - AS NEEDED BY SECTION

TABLE OF CONTENTS

Officers, Councilors, Directors, and Committee Chairs 2003 ...... 62 Calendar of Activities 2003 ...... 68 Reports: Archivist...... 72 Awards Committee ...... 72 Awards Presented by the Northeastern Section ...... 77 Brauner, Phyllis A. - Memorial Lecture...... 78 Constitution & Bylaws Committee...... 81 Continuing Education Committee...... 82 Corporate Funding ...... 85 Education Committee ...... 89 Education Committee / High School Subcommittee...... 96 Esselen Award Committee...... 108 Government Relations Committee ...... 115 Long-Range Planning ...... 116 Medicinal Chemistry Group...... 119 Membership Committee ...... 125 National Chemistry Week Committee...... 127 NERM 2003...... 128 Nominating Committee...... 129 Norris Award Committee ...... 130 Professional Relations...... 134 Program Committee / Chair-Elect ...... 134 Public Relations Committee ...... 136 Public Service Committee/Elementary Education Task Force ...... 140 Publications, Board of...... 140 Richards Medal Committee...... 145 Speakers' Bureau...... 146 Summerthing 2003...... 146 Treasurer ...... 148 Trustees, Board of...... 148

APPENDIX 5-A Complete Program: NSCRC 2003...... 151 Complete Program: Connections to Chemistry ...... 180

61 NORTHEASTERN SECTION OFFICERS / COUNCILORS / CHAIRS -- 2003

Chair Dr. John L. Neumeyer 1 Holiday Road, Wayland, MA 01778 (P) 617-855-3388 (F) 617-855-3585 [email protected]

Chair-elect Dr. Jean A. Fuller-Stanley 4 Mansfield Road, Wellesley, MA 02481 (P) 781-283-3224 [email protected]

Past-Chair Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Secretary Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

Treasurer Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949 [email protected]

Auditor Dr. Anthony L. Rosner 1443 Beacon Street, Apt. No. 201, Brookline, MA 02446 (P) 703-276-7455 (F) 703-276-8178 [email protected]

Trustee Dr. Esther A. H. Hopkins 1550 Worcester Road, Unit 309, Framingham, MA 01702 (P) 508-872-8148 [email protected]

Trustee Mr. Joseph A. Lima 11 Morningside Avenue, Natick, MA 01760 (P) 617-244-5764 (F) 617-254-2713 [email protected]

Trustee Dr. Michael E. Strem Strem Chemicals, Inc., 7 Mulliken Way, Newburyport, MA 01950 (P) 978-462-3191 (F) 978-465-3104 [email protected]

Councilor Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

62 Councilor Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Councilor Dr. Thomas Gilbert Chemistry Department, Northeastern University, Boston, MA 02115 (P) 617-373-4505 (F) 617-373-8795 [email protected]

Councilor Dr. Patricia H. Hamm 806 Bay Road, Stoughton, MA 02072-3957 (H) 781-344-4636 [email protected]

Councilor Dr. Michael J. Hearn Chemistry Department, Wellesley College, Wellesley, MA 02481 (P) 781-283-3127 (F) 781-283-3642 [email protected]

Councilor Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Councilor Dr. William Klemperer Chem. Dept./Harvard Univ, 12 Oxford Street, Cambridge, MA 02138 (P) 617-495-4097 [email protected]

Councilor Dr. Doris I. Lewis 236 Lexington Street, Newton, MA 02466 (P) 617-573-8546 (F) 617-573-8668 [email protected]

Councilor Mrs. Arlene W. Light 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Councilor Dr. Dorothy J. Phillips 10 Lamplight Circle, Natick, MA 01760 (P) 508-482-2860 (F) 508-482-3100 [email protected]

Councilor Dr. Amy Tapper Genzyme Corp., 153 Second Ave., Waltham, MA 02451 (P) 781-434-3518 (F) 781-290-5890 [email protected]

Councilor Mrs. Barbara Wood P. O. Box 198, Melvin Village, NH 03850 (H) 603-544-3351 [email protected]

63 Alternate Councilor Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

Alternate Councilor Dr. Timothy B. Frigo Advanced Magnetics, Inc., 61 Mooney Street, Cambridge, MA 02138 (P) 617-497-2070 (F) 617-547-2445 [email protected]

Alternate Councilor Dr. Wallace J. Gleekman 35 Rangeley Road, West Newton, MA 02465 (P) 617-527-1192 [email protected]

Alternate Councilor Dr. Patrick M. Gordon 1 Brae Circle, Woburn, MA 01801-2222 (P) 781-932-0169 [email protected]

Alternate Councilor Dr. Arno H. A. Heyn 21 Alexander Road, Newton Highlands, MA 02461-1830 (P) 617-969-5712 (F) 617-527-2032 [email protected]

Alternate Councilor Dr. Truman S. Light 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Alternate Councilor Dr. Howard R. Mayne Department of Chemistry, University of New Hampshire, Durham, NH 03824-3598 (P) 603-862-2358 (F) 603-862-2529 [email protected]

Alternate Councilor Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

Alternate Councilor Dr. Donald O. Rickter 88 Hemlock Street, Arlington, MA 02474 (P) 781-643-7575 [email protected]

Alternate Councilor Dr. Lawrence T. Scott Chemistry Department, Boston College, Chestnut Hill, MA 02467 (P) 617-552-8024 [email protected]

Alternate Councilor Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

64 Alternate Councilor Dr. Derk A. Wierda 22 Orchard Drive, Durham, NH 03824 (P) 603641-7148 [email protected]

Director-at-Large Dr. Carmela Amato-Wierda Chem. Dept., Univ. of New Hampshire, Durham, NH 03824-3598 (P) 608-862-2526 [email protected]

Director-at-Large Dr. Henry Brown 39 Varick Road, Waban, MA 02168 (P) 617-244-3663 [email protected]

Director-at-Large Susan M. Chiri-Buta 3 Knox St., #2, Boston, MA 02116 (P) 617-504-4791 [email protected]

Director-at-Large Prof. Dudley Herschbach Chem. Dept./Harvard Univ., 12 Oxford Street, Cambridge, MA 02138 (P) 617-495-3218 (F) 617-495-4723 [email protected]

Director-at-Large Dr. Ernest V. Groman 80 Columbia Street., Brookline, MA 02446 (P) 617-738-8501 [email protected]

Director-at-Large Dr. Gary R. Weisman Dept. of Chemistry, University of New Hampshire, Durham, NH 03824 (P) 603-862-2304 [email protected]

Archivist Dr. Myron S. Simon 20 Somerset Road, West Newton, MA 02465-2722 (P) 617-332-5273 [email protected]

Awards Chair Dr. Michael J. Dube Nye, Inc., P. O. Box 8927, New Bedford, MA 02742-8927 (P) 508-996-6721 (F) 508-997-5285 [email protected]

Board of Pubs. Chair Dr. Patrick M. Gordon 1 Brae Circle, Woburn, MA 01801-2222 (P) 781-932-0169 [email protected]

Budget Chair Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949 [email protected]

65 Chem Hlth/Sfty Chair Ms. Mary Ann Solstad 16 Pequot Road, Marblehead, MA 01945 (P) 781-631-4748 (F) 781-631-1832 [email protected]

Chem. Ed. Chair Dr. Ruth Tanner Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854 (P) 978-934-3662 (F) 978-934-2013 [email protected]

Const./Bylaws Chair Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Continuing Ed. Chair Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

Corporate Funding Dr. James Quick Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x274 [email protected]

Esselen Chair Dr. Arno H. A. Heyn 21 Alexander Road, Newton Highlands, MA 02461-1830 (P) 617-969-5712 (F) 617-527-2032 [email protected]

Local Arrangements Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

Med. Chem. Rep. Ms. Pamela Nagafuji 354 Broadway, #2, Cambridge, MA 02139 (P) 617-583-5359 (F) 617-621-0555 [email protected]

Membership Chair Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

NCW Chair Dr. Christine Jaworek Emmanuel College, 400 The Fenway, Boston, MA 02115 (P) 617-264-7614 [email protected]

NERM Chair Dr. Howard R. Mayne Department of Chemistry, University of New Hampshire, Durham, NH 03824-3598 (P) 603-862-2358 (F) 603-862-2529 [email protected]

66 Nominations Chair Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Norris Award Chair Dr. Frederick D. Greene 25 Canterbury Road, Winchester, MA 01890-3812 (P) 617-253-1840 [email protected]

Nucleus / Editor Dr. Arno H. A. Heyn 21 Alexander Road, Newton Highlands, MA 02461-1830 (P) 617-969-5712 (F) 617-527-2032 [email protected]

Prof. Relations/ Dr. Truman S. Light Career Services 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Program Chair Dr. Jean A. Fuller-Stanley 4 Mansfield Road, Wellesley, MA 02481 (P) 781-283-3224 [email protected]

Project SEED Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Pub. Relations Chair Dr. Mukund S. Chorghade 14 Carlson Circle, Natick, MA 01760 (P) 508-651-7809 (F) 508-651-7920 [email protected]

Pub. Service Chair Dr. Mukund S. Chorghade 14 Carlson Circle, Natick, MA 01760 (P) 508-651-7809 (F) 508-651-7920 [email protected]

Pub. Service/ Dr. James A. Golen Elem. Ed. Task Force Dept. of Chemistry, University of Mass. Dartmouth, No. Dartmouth, MA 02747 (W) 508-999-8245 (F) 508-999-8901 [email protected]

Richards Medal Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Senior Chemists Chair Mr. Charles J. Bardsley 61 Harrison Avenue, Braintree, MA 02184-4911 (P) 781-843-6604 [email protected]

67 Webmaster Dr. Samuel Kounaves Chem. Dept., Tufts University, Medford, MA 02155 (P) 617-627-3124 [email protected]

YCC Chair Ms. Lauren Wolf Chem. Dept., Boston University, Boston, MA 02215 (P) 617-353-3072 (F) 617-353-6466 [email protected]

NESACS CALENDAR OF ACTIVITIES - 2003

Date Activity

January 2003 Call for Nominations: Philip L. Levins Memorial Prize (Graduate Student) January 2003 Call for Nominations: Aula Laudis Society (Secondary Teachers) January 9 Monthly Meeting - MIT Faculty Club Dr. Leslie E. Orgel, Salk Institute, LaJolla, CA Topic: The RNA World and the Origin of Life February 2003 Call for Applications: Norris-Richards Research Scholars (Undergraduate Students) February 2003 YCC-GHCh/JCF Exchange Trip to Germany February 13 YCC Symposium - Alternative Careers for Chemists - Holiday Inn/Newton Speakers: Jack Cunniff (Thermo Finnigan, Regional Sales Manager) Melissa Huang (Rhodia Chirex, Manager--Business Development) Darlene Vanstone (Geltex Pharmaceuticals, Senior Patent Counsel) Two additional speakers February 13 Monthly Meeting - Joint Meeting with YCC - Holiday Inn/Newton Dr. Iona Black (Yale University) Topic: “An Investigation of Bonding in Selected Platinum (II) Complexes” March 2003 Call for Papers: Northeast Student Chemistry Research Conference (Graduate & Undergraduate Students) March 2003 Esselen Award Winner Announced: Bruce D. Roth March 2003 Call for Nominations: Henry A. Hill Award (Service to Northeastern Section) March 2003 Call for Papers: Undergraduate Research Poster Session/ACS - New York March 13 Monthly Meeting - Wellesley College Dr. Felice Frankel / MIT Topic: Envisioning Science; Making Good Science Look Good April 10 Monthly Meeting - Harvard University Gustavus John Esselen Award Dr. Bruce D. Roth, Vice President, Chemistry, Pfizer Global Research Development, Ann Arbor, MI Topic: “The Discovery and Development of Lipitor® (Atorvastatin Calcium)” April 17 Summerthing I - Fenway Park, Boston Boston Red Sox & Tampa Bay Devil Rays Baseball Game April 26 Northeast Chemistry Research Conference - Boston University Student Speakers: Trina L Foster / Boston University Modeling Nature's Pathways: Reproducing the Remarkable Meaghan O’Keefe / Boston College Engineering DNA-electrode connectivities: manipulation of linker length and structure Iron complexes with pentadentate macrocyclic ligands as potential enzyme mimics Justin Tourigny / Boston University

68 Investigating SZ2 Energies of Protonation through Density Functional Theory and the QALE model Andrei Burnin / Dartmouth College) SCnS linear chain production by direct laser ablation Christopher Crafts / Merrimack College Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems Poster Sessions (See NSCRC Report for complete list) German-Exchange Program and 2003 Trip Presentation Capstone speaker: Dr. Charles Lieber / Harvard University Topic: Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things Award Presentations: Brauner Undergraduate Book Award May 08 Monthly Meetng / Education Awards - Boston University Dr. Guy A. Crosby (Consultant, writer, lecturer on food & nutrition chemistry) Topic: “Recent Developments in the Chemistry of Nutrition and Their Impact on Human Health Presentation of Awards: Philip L. Levins Memorial Prize Norris/Richards Undergraduate Research Fellowships Undergraduate Grants-in-Aid Project SEED Certificates Richards Secondary Teaching Awards Aula Laudis Society - Induction of Members Ashdown Examination Prizes Simmons College Prize Phyllis A. Brauner Memorial Book Award May 14 Andrew H. Weinberg Memorial Lecture / Children's Hospital, Boston Dr. Daniel Von Hoff, M.D., Professor of Medicine, University of Arizona and Chief Scientific Officer for US Oncology Topic: Current Approaches to Phase I Chemical Trials May 15 Summerthing II - Fenway Park, Boston Boston Red Sox & Texas Rangers Baseball Game May 19-20 ACS Short Course - Northeastern University LC/MS: Fundamentals and Applications O. David Sparkman / University of the Pacific (Stockton, CA) Frederick E. Klink, Consultant in LC, LC/MS and other scientific instrumentation June 5 NESACS Medicinal Chemistry Group & Swiss House for Advanced Research & Education Joint Symposium Dr. Dalia Cohen, Vice President and Global Head Functional Genomics at the Novartis Institutes of Biomedical Research, Cambridge, MA Title: From Genome to Therapy Aug 4-7 NEACT Summer Conference / Sacred Heart University, Fairfield, CT Newell Grants awarded to four high school teachers to attend NEACT Conference September 2003 Call for Nominations: Richards Medal for Conspicuous Achievement in Chemistry September 2003 Call for Nominations: Gustavus J. Esselen Award (Chemistry in the Public Interest) September 12 Monthly Meeting - Merrimack College, North Andover, MA Dr. Patrick D. McDonald (Waters Corp.) Topic: Evolution of HPLC: An Insider's View October 2003 Call for Applications: Grants-in-Aid (Undergraduate Students) - National Meeting / Anaheim October 2003 Call for Papers: Undergraduate Research Poster Session - National Meeting / Anaheim October 2003 Annual Nucleus Buyers Guide published October 7 Medicinal Chemistry Group Symposium Topic: The Design of Selective Inhibitors Edwin Villhauer, Novartis, East Hanover, NJ Topic: N-Substituted Glycyl 2-Cyanopyrrolidines as a New Family of DPP-IV Inhibitors and Their Potential in Type II Diabetes Dennis Yamashita, Glaxo SmithKline, Collegeville, PA

69 Topic: Peptidomimetic Inhibitors of the Osteoclast-Specific Cysteine Protease Cathepsin K Peter Dragovich, Pfizer Global R&D, San Diego, CA Topic: Discovery of Rupintrivir (AG-7088): A Potent and Selective Human Rhinovirus 3C Protease Inhibitor John Talley, Microbia, Cambridge, MA Topic: Discovery of Celebrex October 8 Connections to Chemistry - High School Teacher Workshop - Burlington (MA) High School Workshop Sessions: A: Performing Effective Chemical Demonstrations John Mauch, Braintree High School and ACS Div. of Chem. Education/H.S. Committee Linda Weber, Natick High School B: Liability in the Laboratory and Classroom Sarah Gibson, Attorney, Mass. Teachers Association C: Will a Match Burn in the Absence of Gravity? Tom Gilbert, Northeastern University D: Exploring Quantum Concepts in Chemistry Alan Crosby & Associates, Boston University Program Speaker: Sally Mitchell, East Syracuse-Minoa Central High School, East Syracuse, NY; Awardee, Northeast Regional ACS Outstanding High School Teacher Award Topic: Around the World on 37 Cents! or How to Find Unusual Resources for Teaching October 9 Monthly Meeting - Wellesley College Club, Wellesley, MA Henry A. Hill Award for Outstanding Service to the Northeastern Section to Doris I. Lewis 50-Year Members of ACS presented certificates of recognition Dr. David Yesair (BioMolecular Products) Topic: Creating a New Biomolecular Enterprise Oct.-Nov. National Chemistry Week Activities October 19 Phyllis A. Brauner Memorial Lecture / Wellesley College Science Center Dr. Bassam Shakhashiri / University of Wisconsin Topic: Earth's Atmosphere & Beyond (two presentations) Kicking off National Chemistry Week 2003 Festivities Variety of hands-on activities October 23 NCW Symposium: What's New in the Air? Atmospheric Chemistry in the 21st Century - MIT Mario J. Molina / MIT Topic: Improving Air Quality in Megacities: Mexico City Case Study Daniel J. Jacob / Harvard University Topic: Air Pollution and Climate Change James G. Anderson / Harvard University Topic: Spectroscopy and Climate Change: Benchmark Observations and Forecast Testing Panel to Answer Questions on the Changing Atmosphere Panelists: Luisa T. Molina / MIT Mario J. Molina / MIT Daniel J. Jacob / Harvard University James G. Anderson / Harvard University Charles E. Kolb / Aerodyne Research November 1 Twelfth Annual Northeast Regional Undergraduate Day / Boston University Keynote Speaker: Prof. Thomas Pochapsky / Brandeis University Topic: Metalloproteins and Metalloenzymes Research Talks & Seminar Prof. Sarah E. O'Connor / MIT Topic: The Biosynthesis of Natural Products Dr. Scot Pounds / Perkin-Elmer Topic: Shortening the Pipeline: Bringing Drugs to Market When Time Is Money Prof. Alex Golger / Boston University Topic: Demonstrations in Chemistry to Fascinate Kids Prof. Scott Schaus / Boston University

70 Topic: Choosing a Graduate School Resume' Review and Graduate School/Industry Fair Dr. Frank Wagner / Strem Chemicals Topic: Preparing Your Resume' Research Talks & Seminar Prof. Sean Elliott / Boston University Topic: Moving Electrons through Proteins Dr. Aaron Beeler / Boston University Topic: Parallel Synthesis and Chemical Library Development including tour of BU Center for Chemical Methodology & Library Development Student Affiliates Workshop Prof. Anthony Fernandez / Merrimack College Topic: Resuscitating a Shallow-Breathing Student Affiliates Chapter November 13 Monthly Meeting / Holiday Inn--Newton James Flack Norris Award Dinner & Program Dr. David N. Harpp / McGill University, Montreal, Canada Topic: Communicating Chemistry -- from Large Classes to the Larger Public November 14-15 Food Chemistry Conference Integrating Food Chemistry, Health Science and Technology into the Chemistry Curriculum Middlesex Community College, Lowell, MA November 20-21 ACS Short Course / Northeastern University Statistical Analysis of Laboratory Data Stanley N. Deming, University of Houston Stephen L. Morgan, University of South Carolina December 2003 Call for Nominations - Norris Award (Outstanding Achievement in the Teaching of Chemistry) December 2003 Call for Nominations - Levins Memorial Prize (Graduate Student) December 11 Monthly Meeting / Radisson Hotel, Woburn / Joint Meeting with the Medicinal Chemistry Group Symposium: New Approaches in the Treatment of Cancer Andre Rosowsky, Dana-Farber Cancer Institute, Boston, MA Topic: History of the Development of PT523--A Potent Folate Antagonist Recently Approved for Clinical Trial Julian Adams, Infinity Pharmaceuticals, Cambridge, MA Topic: Proteasome Inhibitors: Discovery and Development of VelcadeTM (Bortezomib, PS-341) Paul Manley, Novartis Pharma Ltd., Basel, Switzerland Topic: Targeted Drugs for Cancer Therapy. Gleevec: A New Paradigm

71 REPORT OF THE ARCHIVIST - 2003 Myron S. Simon, Ph.D., Archivist

The Archives continue to be located in the basement of the library building at Regis College, Weston, MA.

The normal activities, collecting the reports of the meetings of the Board of Directors and the Board of Publications, the Treasurer’s reports, meeting flyers, photographs, etc. have continued. The annual collections of the issues of the NUCLEUS for the past twenty years have been ring-bound.

Searches have been made to answer questions raised by the chairman of the Norris Award Committee, and by the chairman of the Awards Committee. In the latter case, the text that appears on the plaques given to recent awardees of the Hill Award has been changed to reflect the decisions of the original committee which set up that award. During the year a variety of questions were answered by reference to material in the Archives.

Respectfully submitted, M. S. Simon

REPORT OF THE AWARDS COMMITTEE - 2003 Michael J. Dube, Chair

The responsibility of the Awards Committee for NESACS includes the presentation of two awards issued by the Section. These awards include the Henry A. Hill Award and the Phillip Levins Prize.

The former is awarded to a member of the Northeastern Section for meritorious service. This year the award was presented to Dr. Doris I. Lewis, Professor of Chemistry at Suffolk University. This award was presented at the October local section meeting.

The Levins Prize is awarded to a graduate student demonstrating superior achievement. This year, the award was given to Brian Murphy, University of Massachusetts Dartmouth, under the direction of Prof. Catherine Neto.

Respectfully submitted, Michael J. Dube, Ph.D. Chair, NESACS Awards Committee

72 50-Year Member Invitation to Hill Award Dinner

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

September 3, 2003

Name Address City/St/ZIP

«Salutation»

This year you are celebrating fifty years of membership in the American Chemical Society. I would like to congratulate you on this important milestone in your career as a chemist.

At the October meeting of the Northeastern Section, we will be honoring our fifty-year members. I hope that you (and your spouse) will be able to attend as guests of the Section so that I can congratulate you personally. We are also interested in learning about your career in chemistry. If you would like to do so, we would appreciate receiving a brief biographical sketch that can be added to the archives of the Northeastern Section. It can be sent to the Section office at the address or e-mail shown in the letterhead.

You should already have received a 50-year member lapel pin and a 50-year membership card that entitles you to free registration at ACS National and regional meetings. These were sent to you in March, 2003. If you have not received these, please let me know.

The meeting is on Thursday evening, October 9 at the Wellesley College Club in Wellesley, MA. A flyer is enclosed providing additional information and further details will appear in the October issue of The Nucleus. Please contact Marilou Cashman in the Section office by October 2 to make your dinner reservations. She may be reached by phone or fax at (800) 872-2054 or by e-mail at [email protected].

Again, my congratulations and thanks for your many years of service.

Sincerely,

John L. Neumeyer, Chair Northeastern Section, ACS

73 October Meeting Northeastern Section American Chemical Society The 845th Meeting of the Northeastern Section of the American Chemical Society

DR. DAVID YESAIR BioMolecular Products, Inc. Creating a New Biomolecular Enterprise

Thursday, October 9, 2003 Wellesley College - Wellesley, MA in the Wellesley College Club 5:30 p.m. Social Hour 6:30 p.m. Dinner 50-Year Members to be Honored 7:45 p.m. Evening Meeting: Presiding: Dr. John L. Neumeyer, Chair, Northeastern Section Presentation of the Henry A. Hill Award to Dr. Doris I. Lewis Speaker: Dr. David Yesair

Menu Choices: Citrus Broiled Filet of Salmon - Lemon Grilled Chicken Belle Meuniere - Vegetarian Please indicate choice when making dinner reservations. Dinner reservations should be made no later than noon on Thursday, October 2, 2003. Please send e-mail to [email protected] or call or fax Marilou Cashman at (800) 872-2054 (voice or fax). Reservations not canceled at least 24 hours in advance must be paid.

PRICES: Members: $28.00; Non-Members: $30.00; Retirees: $18.00, Students: $10.00. Pay at the door by cash or check; no credit cards and no purchase orders.

Directions - FREE PARKING ON CAMPUS - Additional information at: http://www.wellesley.edu Wellesley College Club is the last building on the right entering the campus from Route 135 or the first building on the left entering from Route 16 From the West: Take the Massachusetts Turnpike to Exit 14 (Weston). Go south on Interstate 95 (Route 128) for 1/2 mile to Route 16, Exit 21B. Follow Route 16 West for 2.9 miles to a stoplight (5-way intersection) in the town of Wellesley; go straight on Route 135 (West). At the third traffic light take a left into the main entrance of the College. Follow signs for admission parking. OPTIONAL: Take Route 16 or Route 135 heading west to Wellesley; campus is located between these two routes. From the East: Take the Massachusetts Turnpike to Exit 16 (West Newton). Follow Route 16 West for 4.7 miles, using directions above. From the North : Take Interstate 95 (Route 128) South to Exit 21B (Route 16 West). Follow Route 16 West for 2.9 miles, using directions above. From the South: Take Interstate 95 (Route 128) North to Exit 21B (Route 16 West). Follow Route 16 West for 2.9 miles, using directions above. THE PUBLIC IS INVITED

74 Items from The Nucleus-2003

Nomination Dr. Guy A. Crosby, Consultant Henry A. Hill Award for Speaker: May Meeting Outstanding Service to the Education Awards Program Northeastern Section Nominations for the Henry A. Hill Award for Outstanding Service to the Northeastern Section are invited. Nominations should be sent by August 1, 2003 to the Administrative Secretary, NESACS, Marilou Cash- man, 23 Cottage St., Natick, MA 01760. A resume of professional activities and description of the nominee's service to the Northeastern Section should be included. The Award is to be presented at the October meeting of the Section.

Nominations Philip L Levins Memorial Prize

Nominations for the Philip L. Levins Memorial Prize for outstanding performance by a graduate student on the way to a career in chemical science should be sent to the Executive Secretary, NESACS, 23 Cottage St. Natick, MA01760 by March 3, 2003.

The graduate student’s research should be in the area of organic analytical chemistry and may include other areas of organic analytical chemistry such as environmental analysis, biochemical analysis, or polymer analysis. Nominations may be made by a faculty member, or the student may submit an application. A biographical sketch, transcripts of graduate and undergraduate grades, a description of present research activity and three ref- erences must be included. The nomination should be specific concerning the contribution the student has made to the research and publications (if any) with multiple authors. The award will be presented at the May 2003 Section Meeting. Michael J. Dube, Chair, Awards Committee <>

75 50-YEAR MEMBERS RECEIVING CERTIFICATES FROM SECTION CHAIR AT HILL AWARD DINNER OCTOBER, 2003

Section Chair John Neumeyer with 50-Year Member Dr. John Figueras

Section Chair John Neumeyer with 50-Year Member Dr. Robert Stolow

76 AWARDS PRESENTED BY THE NORTHEASTERN SECTION, ACS

James Flack Norris Award Robert G. Bergman University of California/Berkeley in Physical Organic Chemistry (presented at ACS National Meeting)

Gustavus John Esselen Award Bruce D. Roth Pfizer Global Research & Dev. for Chemistry in the Public Interest

James Flack Norris Award David N. Harpp McGill University, Montreal, CAN for Outstanding Achievement in the Teaching of Chemistry

Henry A. Hill Award Doris I. Lewis Suffolk University for Outstanding Service to the Northeastern Section, ACS

Theodore William Richards Award James Miller Bishop Brady High School for Excellence in Teaching Ralph Sherwood Chelmsford High School Coretta Tam Newton Country Day School

Induction into the Aula Laudis Society Anne Woodward Lowell High School Jay Chandler Wayland High School Mary Curtis Belmont High School (retired) Jean Avery Chatham High School

Lyman C. Newell Grants Patricia Brandl Medford High School to secondary teachers to Lorraine Kelly Hull High School attend the NEACT Summer Conference Diane Paskowski Somerset High School Richard Silva East Providence (RI) High School

Philip L. Levins Memorial Prize Brian Murphy University of Mass. Dartmouth

Norris-Richards Undergraduate Summer Pasha Mirazimi Boston College Research Scholarships Travis R. Pribusauskas Bridgewater State College Rozalina Grubina Harvard University Kristin M. Felice Stonehill College

Undergraduate Grants-in-Aid Certificates Justin Towigny Boston University Warren Ansaldo Boston University Andrew Pagano Boston University Toni Lamoureaux University of Mass. Dartmouth

Dr. Phyllis A. Brauner Memorial Book Award Christopher Crafts Merrimack College

Project SEED Certificates Xi Sheng Zheng Charlestown High School Northeastern University Xiang Guo Charlestown High School

Stonehill College Mark Logan, Jr. Apponequet Reg. High School John Silva Brockton High School Thuc Pham Newton Country Day School Bao Truong Quincy High School Songkhla Nguyen Rockland High School

77 Ashdown Examination Awards: First Prize / Simmons College Prize Ziliang Lin Brookline High School Second Prize (tie) Vineel Kankanala Phillips Academy, Andover Second Prize (tie) Adam P. Rosenfield Lexington High School Fourth Lauren M. Forbes Acton-Boxborough High School Fifth Prize (tie) Evan M. Hoke Wayland High School Fifth Prize (tie) Douglas Hammond Malden Catholic High School

Honorable Mention - 1st-year Students Andrew Hsiao Phillips Academy, Andover Li-Mei Lim Lexington High School Matthew Tai Cambridge Rindge & Latin H.S. Ryan Davis Phillips Academy, Andover Yao Liu Lexington High School Sunny Lou Wayland High School Jason Whittaker Wayland High School

Honorable Mention - 2nd-year Students Caitlin H. Donovan Wayland High School Akshay Ganju Brookline High School Sean P. Sullivan Acton-Boxborough High School Alex C. Liu Acton-Boxborough High School Laura Schoenherr Phillips Academy, Andover Jonathan M. Hessney Brookline High School

REPORT OF THE PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE - 2003 Doris I. Lewis, Chair

Members of the Phyllis A. Brauner Memorial Lecture Committee are:

Inka Allen Michaelene Chen Sarah Iacobucci Katherine O’Sullivan Steven Allen Dudley Hershbach Ann Jenkins Bassam Shakhashiri Catherine Brauner Arno Heyn Doris I. Lewis Carolyn Spodick Susan Brauner Esther A. H. Hopkins Julianna Lovell Valerie Wilcox

78 On Sunday, October 19th, the Northeastern Section and Wellesley College sponsored and hosted a daylong event as part of the NESACS 2002 National Chemistry Week celebration. Members of the Brauner Committee assisted with organization and participation in events of the day Among the highlights of the day, Prof. Bassam Shakhashiri of U.Wisconsin-Madison gave two presentations of the Phyllis A. Brauner Memorial lecture. These captivating lectures were enjoyed by children and adults alike; photos may be viewed as part of the NESACS NCW report. Additionally, hands-on activities demonstrating the NCW theme were presented by volunteers from local colleges.

A major event in the establishment of the Brauner endowment occurred at the April 10 meeting of the Board of Directors at the Harvard University Faculty Club, when the Board voted to establish the Phyllis A. Brauner Memorial Fund using $25,000 of temporarily restricted assets from the Permanent Trust currently residing in the Consolidated Account. The effect of this transaction was to reduce the Permanent Trust Fund’s share of the Consolidated Account from approximately 16% to 14% in order to designate approximately 2% of the Consolidated Account as the Brauner Fund. In addition, a new account was opened as the income account for the Brauner Fund.

The account as recorded in the Section Minutes is as follows: Motion by D. Lewis. Second by J. Piper: · That there be established in the Trust funds of the Northeastern Section of the American Chemical Society two accounts: § A. The Phyllis Brauner Memorial Fund in the Consolidated Trust Fund of the section, and, § B. The Phyllis Brauner Memorial Lecture Income Account.

· The Phyllis Brauner Memorial Lecture Fund Trust will be originally funded by $25,000.00 from the Permanent Trust. · The Phyllis Brauner Memorial Fund Income Account is set up to receive the proportionate earnings from the Phyllis Brauner Memorial Lecture Fund Trust as set up above in the Consolidated Account of the Trusts of the Section and to receive funds deposited in it by individuals, foundations, and/or corporations in Memory of Dr. Brauner. · The motion passed to establish the Brauner Fund by a voice vote.

Brauner Fund Report – 2003 (Submitted by NESACS treasurer Jim Piper)

> Cash in operating account 12/31/02 - $5579.52 > 2003 Cash gifts $6288 > 2003 Stock gifts $1822 > 2003 Transfer to Brauner endowment $25,000

> As of 11/30/03 the Memorial lecture account was valued at $13,263.22 and the > Brauner portion of the Consolidated Account was 2.0771% of $1,486,215.51 or > $30,870.18.

Respectfully submitted, Doris I. Lewis, Chair

79 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE

DR. DORIS I. LEWIS PHONE: (617) 573-8546 SUFFOLK UNIVERSITY FAX: (617) 573-8668 41 TEMPLE STREET [email protected] BOSTON, MA 02114

October 8, 2003

Dear Friend of the Phyllis A. Brauner Lecture,

Sincerely yours,

Doris I. Lewis, Chair Phyllis A. Brauner Memorial Lecture Committee [email protected] 617-573-8546

80 REPORT OF THE COMMITTEE ON AMENDMENTS TO THE CONSTITUTION AND BYLAWS - 2003 Catherine E. Costello, Chair

The committee was composed of the following members:

Catherine Costello, Chair Arno Heyn Truman Light Esther Hopkins Myron Simon The Board of Directors of the Northeastern Section is presently considering the modification of the Constitution and Bylaws of the Section to introduce an award in honor of Phyllis Brauner, a former Section chair who contributed significantly to the success of the Section over many years. A draft of the proposed change was sent to the national C&B committee in late 2001 to solicit their opinion on the wording of the changes prior to presentation of the matter to the Section as a whole for formal approval. The national committee has informed us that they have an extensive backlog of requests but should have a response available soon. No other C&B changes are under discussion at the present time.

Catherine E. Costello Chair, NESACS C&B Committee

Contact person: Prof. Catherine E. Costello Mass Spectrometry Resource Boston University School of Medicine phone: 617-638-6490 715 Albany Street, R-806 fax: 617-638-6491 Boston, MA 02118-2526 e-mail: [email protected]

81 COMMITTEE ON CONTINUING EDUCATION 2003 Annual Narrative Report Northeastern Section

Following the tradition of recent years, the Committee scheduled two events in 2003. Both were held at Northeastern University, which kindly made the required facilities available at no charge to the Section. Since 1993, when we learned that National ACS had decided to make ACS Short Courses available to local sections at tuition fees greatly reduced from the normal fee structure, currently in the vicinity of $1000, this Committee has sponsored Short Courses under this aegis. Since our original offering in the Fall of 1993 proved to be a highly successful event, the Committee has continued to bring such courses to the Northeastern Section.

1) In the Spring of 2003 the Committee sponsored the two-day ACS Short Course: LC/MS: Fundamentals and Application Monday, May 19, 2003: 8:00 a.m. – 5:00 p.m. and Tuesday, May 20, 2003: 8:30 a.m. - 5:00 p.m. Paid registration: 17. Total attendees: 22. 12 ACS Members @ $500 5 Non-ACS Member @ $600 5 Unemployed ACS Member no charge (In addition, 1 registrant was assessed the late-registration fee of $75) Instructor: Dr. O. David Sparkman (Adjunct Professor, University of the Pacific)

2) In the Fall the Committee sponsored the two-day ACS Short Course: Statistical Analysis of Laboratory Data. Thursday, Nov. 20, 2003: 8:00 a.m. - 4:00 p.m. and Friday, Nov. 21, 2003: 8:30 a.m. - 5:00 p.m. Paid registration: 19. Total attendees: 21 9 ACS Members @ $500 10 Non-ACS Member @ $600 1 Lecturer’s assistant no charge 1 Northeastern University Post-doctoral Fellow no charge

(In addition, 9 registrants were assessed the late-registration fee of $75) Instructor: Professor Emeritus Stanley N. Deming (University of Houston)

In accord with National ACS policy, unemployed and retired ACS members were offered admission without charge on a space-available basis.

The above fee schedule included an increment of $50 above the charges set by National ACS, calculated to offset Committee expenses on the basis of the minimum number of 10 registrants required for presentation of the course. The Section also keeps the incremental fees charged to Non-ACS members and to late registrants. Since the number of registrants for the both courses exceeded the minimum required to offset expenses and advertising costs, participants were invited to a luncheon hosted by the Committee. Due to the healthy enrollment in both courses, the relatively large component of Non-ACS Members, and the relatively large numbers of late registrants, the remaining revenues for the year, after payment to National ACS of their share of tuition revenues, were more than sufficient to cover the Section's expenses and provided a surplus in excess of $3,100 for the support of other Section activities.

Both events were advertised in The Nucleus (copies attached) and posters were mailed to ca 550 employers of chemists on the list maintained by the Northeastern Section. Notices of the Short Courses were posted on the Sections web site and were also sent to about 75 e-mail addresses maintained by the Section Office. The Committee feels that the wide variety of individuals who participated in these two events, representing 20 different organizations, made these efforts worthwhile. E. Joseph Billo Vishnu C. Solan James Hall Alfred Viola, Chair Mary Mahaney

82 ACS SHORT COURSE Designed to improve the skills and marketability of practicing B.S., M.S., and Ph.D. chemists. The NESACS Committee on Continuing Education is pleased to sponsor this newly updated National ACS Two-Day Short Course, at a registration fee less than half of that charged at National ACS Meetings. LC/MS: Fundamentals and Applications In this course you will receive an overview of applications for the environmental, biotechnology, pharmaceutical, and chemical industries, and for areas of forensics and toxicology.

This Short Course is designed as a practical overview of LC/MS for researchers, practitioners, technicians and others who are currently using LC, LC/MS, or plan to do so in the future, and those dealing with data produced by LC/MS. Practitioners just embarking on the technique will gain insight to select the appropriate instrument for different applications, and those currently using LC/MS and its data will develop an appreciation for, and an understanding of, the complexities of the data generated. Participants should bring a basic calculator to the course.

DATES and TIME: Thursday, May 19, 2003; 8:00 a.m. – 5:00 p.m. and Friday, May 20, 2003; 8:30 a.m. – 5:00 p.m. PLACE: Egan Center, Room 340, Northeastern University, 360 Huntington Ave., Boston, MA PROGRAM AGENDA: · Solvent delivery systems, columns, interfaces, ionization methods, and mass analyzers; methods; data evaluation · What types of instruments are available for various types of analyses · What are the latest developments in instrumentation · How to get structural information from LC/MS · How to deal with multiple-charge ions · What changes may have to be made when porting LC method to an LC/MS method · Types of mass analyzers, and which is most suitable for a given analysis by LC/MS · Steps in the interpretation of collisionally activated dissociation (CAD) data · How ions are formed in an LC/MS analysis · Approaches to problem solving with LC/MS INSTRUCTORS: (These are two of the most highly rated instructors in the ACS continuing education program.) O. David Sparkman, Adjunct Professor of Chemistry at the University of the Pacific, Stockton, Cal., a consultant to the NIST Mass Spectrometry Data Center, teaches courses in mass spectrometry and analytical chemistry and manages the mass spectrometry facility. He is on the Editorial Advisory Boards of the Journal of the American Society for Mass Spectrometry and the HD Science GC/MS Update – Part B. He is the author of Mass Spectrometry Desk Reference, and co-developer of the Mass Spectral Interpretation Quick Reference Guide. Frederick E. Klink, currently a consultant in LC, LC/MS, and other scientific instrumentation, has worked with a variety of industrial clients. He has over 16 years of experience in a variety of technical and managerial positions in the analytical instrument industry. Starting as a life sciences applications chemist in HPLC, he has worked in product development, and product and marketing management for a major HPLC manufacturer. PRE-REGISTRATION REQUIRED – Registration Fees: ACS Members if received before May 2…..…… $500.00; after May 2 ……$575.00 Non-ACS Members if received before May 2 ..…$600.00; after May 2 ……$675.00 There will be a limited number of scholarships for unemployed ACS Members on a space-available basis. Parking Fee: about $14.00/day University cafeterias will be available for lunches. For further information contact: Prof. Alfred Viola at (617) 373 2809 Short Course Registration form: LC/MS: Fundamentals and Application. May 19 – 20, 2003

Name: ______Business Affiliation: ______

Mailing ______Telephone: ______Address ______E-mail ______

Mail with remittance to: Prof. Alfred Viola, Chair (Please make checks payable to NESACS. NESACS Committee on Cont. Ed. Sorry, we cannot accept credit cards or Department of Chemistry purchase orders.) Northeastern University Boston, MA 02115

83 ACS SHORT COURSE

Designed to improve the skills and marketability of practicing B.S., M.S., and Ph.D. chemists. The NESACS Committee on Continuing Education is pleased to sponsor this newly updated National ACS Two-Day Short Course, at a registration fee less than half of that charged at National ACS Meetings. Statistical Analysis of Laboratory Data This Short Course is designed for scientists, engineers, technicians, laboratory managers, R&D managers, manufacturing and production managers and others who need to understand traditional and modern methods of data analysis. This course assumes no previous knowledge of statistics and is aimed at both beginning and experienced workers. Participants should bring a hand-held calculator to the course.

DATES and TIME: Thursday, Nov. 20, 2003; 8:00 a.m. – 4:00 p.m. and Friday, Nov. 21, 2003; 8:30 a.m. – 5:00 p.m. PLACE: 450 Dodge Hall, Northeastern University, 360 Huntington Ave., Boston, MA

PROGRAM AGENDA: Describing Variability with the Standard Deviation One-Way Analysis of Variance (ANOVA) Characteristics of Measurement Uncertainty Detecting and Rejecting Outliers Uncertainties of Parameter Estimates Sensitivity, Selectivity, and Limit of Detection Pooling Estimates of Variability Nonparametric Statistical Methods Confidence Intervals on the Population Mean Least Squares for Model Fitting Confidence Intervals on the Population Standard Deviation Diagnostic Tests for Judging the Adequacy of a Model Introduction to Statistical Inference Evaluating Measurement Processes with Control Charts An Overview of t-Tests Detecting Instability of a Measurement Process Specification Testing Methods of Transfer and Validation – Youden Plots, The F-Test Ruggedness Testing Understanding Statistical Hypothesis Tests INSTRUCTORS: Stanley N. Deming, Professor Emeritus of Analytical Chemistry at the University of Houston and the President of Statistical Designs. PRE-REGISTRATION REQUIRED – Registration Fees: ACS Members if received before Nov. 4…..…… $500.00; after Nov. 4 ……$575.00 Non-ACS Members if received before Nov. 4 ..…$600.00; after Nov. 4 ……$675.00 There will be a limited number of scholarships for unemployed ACS Members on a space-available basis. Parking Fee: about $14.00/day University cafeterias will be available for lunches. For further information contact: Prof. Alfred Viola at (617) 373 2809

Registration form for Short Course: Statistical Analysis of Laboratory Data. Nov. 20 – 21, 2003

Name: ______Business Affiliation: ______

Mailing ______Telephone: ______Address ______E-mail ______

84 REPORT OF THE COMMITTEE ON CORPORATE FUNDING - 2003 James Quick, Chair

The Business Liaison Committee met four times during the year. The members, Jim Quick (Chair), Mike Strem, Amy Tapper and David Yesair, felt that all approaches to corporations for donations to support the section's activities should go through the Committee. New solicitations should be tailored to the support of specific activities if possible. We also changed the names and the limits of the support levels. For gifts of $2,000 or greater they will be listed as a Benefactor while gifts of $1,000 or $500 will be acknowledged as a Corporate Patron or Corporate Sponsor respectively.

The committee sent 11 letters to former donors requesting a renewal of their donations to the Section. Nine positive responses were received for a total of $4,050. A further 60 letters were sent to companies on the mailing list that had specific contacts. Only one response was received concerning a possible donation from the Millipore Foundation. That is still pending.

A planned third mailing to support the activities of the Med Chem Group was canceled at the request of Amy Tapper.

I have attached a file summarizing the results, as well as examples of the first and second letters and the mailing list that was used.

Submitted, Jim Quick

NEACS Business Liaison Results

2000 2001 2002 2003 Letters Sent 335 0 335 11 2nd mailing 383 60

Aerodyne $250 $250 $500 AstraZeneca $1,000 $1,000 Cambridge Isotope $250 $500 Consulting Resources $50 $50 Houghton Chemicals $250 $250 $250 New England Biolabs $500 $500 $500 Novartis $1,000 Organix $250 $250 $250 Polymedica $250 Sigma-RBI $500 $500 $500 Strem Chemicals $1,000 $1,000 $500 Tropix $250 $3,000 $0 $5,300 $4,050

85 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

May 19, 2003

Name Company Street City/St/Zip

Dear [name]:

The Northeastern Section of the American Chemical Society (NESACS) thanks you for your company’s generous support of $1,000 in 2002. Your generosity has helped to build a strong, vibrant chemical society. Our section is one of the five largest in the Society and, in 2002, was voted the best in this super-large group. With your help we can continue to maintain that high level of activity. The Northeastern section’s most recent and continuing activities have included support of our younger chemists and students through exchange visits with the Jungchemikerforum of the German Chemical Society, Project SEED and the ACS Scholars Program. The section also proudly sponsors several nationally recognized ACS awards including: James Flack Norris Awards for Physical Organic Chemistry and for Outstanding Achievement in the Teaching of Chemistry; Gustavus John Esselen Award for Chemistry in the Public Interest; and, the Theodore William Richards medal for Achievement in Chemistry. A further effort to expand the public awareness of chemistry has lead to the establishment of the Phyllis A. Brauner Memorial Lecture during National Chemistry Week. The medicinal chemistry group is another specialized activity that the section has supported for many decades.

Your support is crucial for the continuation and expansion of these activities. For example, the estimated cost of the exchange program in 2004 is $30,000 more than what the section can budget for it. Please consider extending your generosity again and, if possible, expanding it. Your corporation’s gift will be acknowledged in the section’s monthly publication, THE NUCLEUS, and at NESACS functions. For gifts of $2,000 or greater you will be listed as a Benefactor while gifts of $1,000 or $500 will be acknowledged as a Corporate Patron or Corporate Sponsor respectively.

Please send your donation to “Northeastern Section ACS” at the above address, Attn: Dr. James Piper, Treasurer. Please also include your corporate name for our public acknowledgements. The Northeastern Section of the American Chemical Society, Inc. is a 501c3 non-profit corporation with tax ID Number 04-6037800.

Again, thank you,

James Quick Chair, Business Liaison Committee Northeastern Section of the American Chemical Society (NESACS) 508-651-8151 x274 [email protected]

86 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

September 3, 2003

Name Company Street City/St/Zip

Dear [Name]:

The Northeastern Section of the American Chemical Society (NESACS) would like to ask you for your company’s support of its 2003 program. Our section is one of the five largest in the Society and, in 2002, was voted the best in this super-large group. With your help we can continue to maintain that high level of activity. The Northeastern section’s most recent and continuing activities have included support of our younger chemists and students through exchange visits with the Jungchemikerforum of the German Chemical Society, Project SEED and the ACS Scholars Program. The section also proudly sponsors several nationally recognized ACS awards including: James Flack Norris Awards for Physical Organic Chemistry and for Outstanding Achievement in the Teaching of Chemistry; Gustavus John Esselen Award for Chemistry in the Public Interest; and, the Theodore William Richards medal for Achievement in Chemistry. A further effort to expand the public awareness of chemistry has lead to the establishment of the Phyllis A. Brauner Memorial Lecture during National Chemistry Week. The medicinal chemistry group is another specialized activity that the section has supported for many decades.

Please send your donation to “Northeastern Section ACS”, Attn: Dr. James Piper, Treasurer, 19 Mill Road, Harvard, MA 01451. Please also include your corporate name for our public acknowledgements. The Northeastern Section of the American Chemical Society, Inc. is a 501c3 non-profit corporation with tax ID Number 04-6037800.

Again, thank you,

James Quick Chair, Business Liaison Committee Northeastern Section of the American Chemical Society (NESACS) 508-651-8151 x274 [email protected]

87 Sample Companies from Mailing List

Mail returned as undeliverable Donated in 2003 mass mailed in September 2003

NAME TITLE COMPANY The President ACTON RESEARCH CORP. The President ACUSHNET CO-RUBBER DIV The President ADVANCED SURFACE TECH INC. Dr. Chuck Kolb AERODYNE RESEARCH INC The President AIR PRODUCTS AND CHEMICALS The President ALBANY INTERNATIONAL RESEARCH CO. The President ALCATEL VACUUM PRODUCTS, INC. Mr. Barry Singlais ALFA AESAR, A JOHNSON MATTHEY CO. The President ALKERMES INC. The President ALPCO LTD The President ALTUS BIOLOGICS The President AMERICAN DURAFILM CO. The President AMERICAN TECH SYSTEMS CORP The President AMERTECK AEROSPACE PROD INC. The President AMRAY, INC. The President ANALOG DEVICES The President ANALYTICAL ANSWERS INC The President ANDOVER CORPORATION The President ANGIO MEDICAL CORP. Director of Research APHIOS CORPORATION The President APPLIED BIOTECHNOLOGY Dr. Scott Chapel ARES ADVANCED TECHNOLOGY INC. The President ARIAD PHARMACEUTICALS INC The President ARLIN MFG CO INC Dr. Sheila H. DeWitt ARQULE INC Dr. Scott T. McMillan ARTISAN INDUSTRIES INC The President ASPEN TECH Dr. William Michne ASTRA ARCUS USA Dr. Trevor J. Trust ASTRA ZENECA RESEARCH The Manager ATOCHEM TURCO-PUREX PLANT

88 Corporate Patrons

AstraZeneca R & D Boston

Corporate Sponsors

Aerodyne Research, Inc. Cambridge Isotope Labs New England BioLabs, Inc. Sigma-RBI Strem Chemicals, Inc.

Donors

Consulting Resources Corporation Houghton Chemical Corp. Organix, Inc

REPORT OF THE EDUCATION COMMITTEE - 2003 Ruth Tanner, Chair

Education Committee Members

Ruth E. Tanner, Chair College Stephen Lantos High School Subcommittee Chair Anthony Fernandez Student Affiliates Morton Hoffman ACS Scholars

The Education Committee continued to take an activist position with regard to the organizing of events, the creation of awards, and the recognition of students and faculty in the colleges, universities, and high schools of the Section. Through announcements at the monthly meetings of the Section, in The Nucleus, and via mailings, information was provided to the membership in order to foster a greater interest in chemical education and to develop a responsible professional outlook toward chemistry among young scientists.

Morton Hoffman, who is a member of the Education Committee, was the Immediate Past-Chair of the Northeastern Section in 2003; he is also a member of the Education Committee. He was elected in 2003 as Chair-Elect (2004) and Chair (2005) of the Division of Chemical Education (CHED), and serves as a member of the CHED Program Committee, Chair of the CHED Regional Meetings Committee, and a member of the CHED International Activities Committee. He is a member of SOCED, and served as a member of the Organizing Committee and a panel moderator of the SOCED Invitational Conference on Exploring the Molecular Vision. He served as a member of the organizing committee of the ACS Invitational Conference on Chemistry Research and Education in the Middle East, and as a member of the Editorial Review Panel for the general chemistry textbook project of the ACS Education Division. In November 2003, he delivered the Arthur Sweeny, Jr., Memorial Lecture at Lehman College of the City University of New York.

89 James Flack Norris/Theodore William Richards Undergraduate Summer Research Scholarships. (Subcommittee: Edwin Jahngen, Chair; Michael Hearn, Kevin Whitburn)

Awards of $3250 each (including $500 for support of the research) were presented in May to four undergraduates from among 18 well-qualified applicants. The 2003 recipients were: · Pasha Mirazimi, Boston College, Development of Models for the Dynamics of Oligomeric DNA through Solid State Nanopore Channels; Prof. Udayan Mohanty, Advisor · Travis R. Pribusauskas, Bridgewater State College, Synthesis of Solvated Molybdenum Clusters from Molybdate; Dr. Steven Haefner, Advisor · Rozalina Grubina, Harvard University; Assembly of a Cyclic Small Molecule Library Using DNA-Templated Synthesis; Prof. David R. Liu, Advisor · Kristin M. Felice, Stonehill College; Modeling the Zn2+ Coordination Sites of Zinc Metalloenzyme Using Peptide Phage Display; Prof. Marilena Hall, Advisor

Twelfth Annual Northeast Regional Undergraduate Day (Coordinated by John Snyder, Kevin Burgoyne and Morton Hoffman and Hosted by Chemia, SAACS at Boston University)

More than 145 undergraduates and faculty from 21 colleges and universities in the Northeastern Region and beyond, met on November 2, 2003, at Boston University for this annual event. The keynote address, Metalloproteins and Metalloenzymes, was given by Prof. Thomas Pochapsky from Brandeis University. Small group topics and seminars followed that included:

· Choosing a Graduate School (Prof. Scott Schaus, Boston University) · Demonstrations in Chemistry to Fascinate Children (Prof. Alex Golger, Boston University) · Resume Review (Dr. Frank Wagner, Strem Chemicals) · Reviving a Shallow-Breathing SA Chapter (Prof. Anthony Fernandez, Merrimack College) · The Biosynthesis of Natural Products (Prof. Sarah O’Connor, MIT) · Bringing Drugs to Market When Time is Money (Dr. Pounds, Perkin Elmer) · The Interplay Between Biological Systems and Redox-Active Species (Prof. Sean Elliott, Boston U.) · Parallel Synthesis and Chemical Library Development (Dr. Aaron Beeler, Boston University)

A graduate school and industry fair provided students with the opportunity to obtain information from representatives of universities and industries. A nominal registration fee was charged to offset the costs of refreshments and materials. The Undergraduate Day was a National Chemistry Week activity, and was sponsored by the NESACS Education Committee.

The Second Undergraduate Environmental Research Symposium. Sponsored by the Education Committee of the Northeastern Section ACS et al., Bridgewater State College

90 President, Pfizer Global Research and Development. The title of Dr. Cue’s presentation was, “Green and Sustainable Chemistry – A Perspective From Pfizer”.

The Two-Year College Chemistry Consortium Chemistry Conference (2YC3). Sponsored by the Education Committee of NESACS, et al., Middlesex Community College.

The Education Committee was a sponsor for the2YC3 (Two-Year College Chemistry Consortium) chemistry conference entitled Exploration in Chemical Education at Middlesex Community College on November 14 and 15.

The “Explorations in Chemical Education” conference, subtitled “Integrating Food Chemistry, Health Science, and Technology into the Chemistry Curriculum” drew more than one hundred high school and college teachers to Middlesex Community College on November 14 and 15. Participants arrived from all of the Northeastern states as well as from many mid-western and western United States.

The conference opened with “The Chemistry and Controversy of Genetically Modified Foods" by the Science in the News program at Harvard Medical School. This topic lends itself to teaching critical thinking through problem-based learning and to expanding the public’s understanding of chemistry and biology. Cutting-edge research in areas such as diet and Alzheimer’s Disease, carotenoid supplements and lung cancer, and food chemistry research for the military were interspersed with presentations and hands-on laboratory segments focused on teaching methodology. These included a popular demonstration of mercury analysis in a freshly caught fish using cold vapor AA, as a “platform for teaching abstract concepts”. The Chem Connections workshop, sponsored by the ACS and NSF, provided a modular program for teaching chemistry in context. Writing to learn, deep understanding of the scientific method, Webquests, integrating math and chemistry, inquiry-based learning, assessment with demonstrations and the titration project laboratory were additional well-attended sessions. Valuable laboratory safety and grant writing presentations as well as tours to the research reactor at the University of Massachusetts Lowell and to the Natick Food Research Labs rounded out the program. The banquet speaker highlighted the role of science in the evolution of Lowell as the birthplace of the industrial revolution in the United States.

The other major sponsors were the New England Association of Chemistry Teachers (NEACT) and the ACS Division of Chemical Education.

The Northeast Student Chemistry Research Conference (IV). Sponsored by the Education Committee of the Northeastern Section ACS and the Younger Chemists Committee of the Northeastern Section

91 scientific understanding. The Symposium featured poster presentations by undergraduate and graduate students from area colleges and universities. The keynote address, Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things, was given by Dr. Charles Lieber of Harvard University.

In addition to the poster presentations, there were six student presentations: three undergraduate student speakers and three graduate student speakers. The presenting students and their institutions were: · Trina Foster, Boston University: Modeling Nature’s Pathways: Reproducing the Remarkable · Meaghan O’Keefe, Boston College: Engineering DNA-Electrode Connectivities · Ivan Korendovych, Tufts University: Iron Complexes and Pentadentate Macrocyclic Ligans as Potential Enzyme Mimics · Justin Tourigny, Boston University: Investigating SZ2 Energies of Protonation through Density Functional Theory and the QALE Model · Andrei Burnin, Dartmouth College: SCnS Linear Chain Production by Direct Laser Ablation · Christopher Crafts, Merrimack College: Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems

Two of the undergraduate speakers were the students who had been awarded the NESACS James Flack Norris/Theodore William Richards Undergraduate Summer Research Scholarships for the summer of 2001.

A presentation of the Phyllis Brauner Undergraduate Book Award was made by Susan Brauner at the conference. Cathy Brauner was also present for the award that was given to Christopher Crafts from Merrimack College. The title of his oral and poster presentation is given above.

A copy of the total program appears at the end of Appendix 5 of the ACS Report.

Grants -in -Aid to Undergraduates (Subcommittee: Ruth Tanner, Martin Isaks)

· Elisa Miller, Boston University, (Prof. Amy Mullin) Chemical Dynamics of high Energy Molecules: The Role of State Density in Collisional Relaxation · Karen DeBalsi, Bridgewater State College, (Prof. Edward Brush) Synthesis, Purification and Characterization of Glutathione Dialkylester Conjugates with 3-Methyleneoxindole · Renato Bauer, Stonehill College (Prof. Louis Liotta) Conversion of D-Galactose to D-Talose and the Subsequent Synthesis of Polyhydroxylated Pyrrolidines · Claudia Moura, Merrimack College (Prof. Anthony Fernandez) Investigation of the p-acidity of Phosphorus (III) Ligands Using UV-Vis Spectroscopy · Shaina Byrne, Stonehill College (Prof. Leon Tilley) Synthesis and Solvolysis of Trifluormethyl Gamma Substituted Silyl Systems

In addition, three grants were given to the Norris/Richards Scholarship Recipients mentioned earlier in the report: · Travis R. Pribusauskas, Bridgewater State College, Synthesis of Solvated Molybdenum Clusters from Molybdate; Dr. Steven Haefner, Advisor

92 · Rozalina Grubina, Harvard University; Assembly of a Cyclic Small Molecule Library Using DNA-Templated Synthesis; Prof. David R. Liu, Advisor · Kristin M. Felice, Stonehill College; Modeling the Zn2+ Coordination Sites of Zinc Metalloenzyme Using Peptide Phage Display; Prof. Marilena Hall, Advisor

CONNECTIONS TO CHEMISTRY (Ruth Tanner, Chair)

Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Chair, NESACS; Boston University Susan Buta, Chemistry Faculty, Lincoln-Sudbury ( MA) Regional High School Steve Lantos, Chemistry Faculty, Brookline (MA) High School Jerusha Vogel, Chemistry Faculty, Lexington (MA) High School

The high school chemistry teachers were welcomed to the program by Ruth Tanner (University of Massachusetts Lowell), Chair of the NESACS Education Committee and Chair of the Connections to Chemistry program. Steve Lantos, Chair of the High School Education SubCommittee (NESACS), welcomed his high school colleagues. He highlighted the ACS resources available for high school teachers, and encouraged them to utilize these resources.

The following afternoon workshops were offered to showcase the ACS resources for high school chemistry teachers and students: Four Simultaneous Workshops in Two Sessions: Session I: 4:30 – 5:15 Session II: 5:25 – 6:10

Workshop B: Liability in the Laboratory and Classroom Attorney Sarah Gibson, sponsored by the Massachusetts Teachers Association

Workshop C: NCW, Will a Match Burn in the Absence of Gravity? Thomas Gilbert, Associate Professor of Chemistry and Education, Northeastern University

Workshop D: Exploring Quantum Concepts in Chemistry Alan Crosby and Associates, Department of Chemistry; and Peter Garik, School of Education, Boston University (A two session workshop, 4:30 - 6:10)

93 raffled, including subscriptions to J. Chem. Educ., affiliate memberships in CHED, ACS Chemical Education Division CD’s and software, and several ACS logo products. To conclude the program, participants were given a certificate awarding professional development credits, a year’s subscription to ChemMatters, and a year’s associate membership in the Northeastern Section of the ACS.

The event received material assistance from the ACS, and publicity support from the New England Association of Chemistry Teachers, the Massachusetts Association of Science Supervisors, the Massachusetts Association of Science Teachers, Science Teachers Area Resources Swap and the New England Science Teachers. The Program Conference Committee also received support from various high schools and industries: Sarah Iacobucci, Chair, National Chemistry Week, NESACS; Tufts University Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Nancy Spicer, Research Scientist, Industrial Consultant Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell John Riley, Membership Chair, Chemistry and Law, American Chemical Society

The Connections program received substantial material assistance from the ACS, and the editorial staff of the Journal of Chemical Education:

Elizabeth Moore, Associate Editor, Journal of Chemical Education Lin Morris, Assistant Editor, Journal of Chemical Education Helen Herlocker, Managing Editor, ChemMatters Robin Giroux, Assistant Managing Editor, Editing & Production, Chemical and Engineering New William Robinson, Chair, Division of Chemical Education, ACS

Publicity support was received from the New England Association of Chemistry Teachers, the Massachusetts Association of Science Supervisors, the Massachusetts Association of Science Teachers, Science Teachers Area Resources Swap and the New England Science Teachers.

ACS Scholars Program (Morton Hoffman, Chair)

ACS Scholars - 2002-2003 academic year.

This is the fourth year for the involvement of the NESACS in the ACS Scholars Program. The NESACS sponsored one student, Marlita Taylor, who graduated from MIT in June 2003 as a chemistry major.

In the 2002-03 academic year, 17 Scholars studied within NESACS:

DARTMOUTH COLLEGE Michael J. Duncan

HARVARD UNIVERSITY Jessica G. Bazick Sharon O. Doku Adan Farinas Christina Ann Fields Lauren M. Goins Daniel D. Golab Roy G. Hughes

94 MASSACHUSETTS INSTITUTE OF TECHNOLOGY Felipe R. Anziani Pedro L. Arrechea Elisa E. Calimano Nydia M. Clayton Reuben L. Cummings Christiana O. Obiaya Keith G. Reed Marlita N. Taylor (NESACS Scholar) Ida G. Wahlquist-Ortiz

These Scholars were contacted by e-mail monthly from January to May, and informed of NESACS activities of interest to undergraduates. In particular, they were invited to attend the monthly meetings of the Section, and to be its guests at the social hours and dinners that preceded the invited speakers. They also were put on the mailing list to receive The NUCLEUS. Unfortunately, during that period, no Scholars attended the Section meetings or were involved in any undergraduate activities.

With the start of the 2003-04 academic year, requests were made to the ACS for the names, addresses, and e-mail addresses of the Scholars at institutions within the Section, and advise on the mechanism for selecting the NESACS Scholar. As of the end of the calendar year, no information had yet been received from the ACS.ACS Scholars

A letter written by the Chair-Elect inviting the ACS Scholars to attend the October meeting follows: Dear ACS Scholars;

NESACS October 9th Meeting:

I would like to invite you to attend the October 9th meeting of the Northeastern Section of the American Chemical Society (NESACS). As ACS Scholars you will be the guest of the section and as such you do not have to pay for your dinner. The October meeting is particularly important, since the Henry Hill Award is given at that meeting. Henry Hill was the Northeastern Section first African American Section Chair in addition to being a great chemist and fantastic mentor and role-model.

The meeting will be held at Wellesley College and information will be in the October issue of The Nucleus, The NESACS Monthly Publication.

The schedule for the meeting is as follow: 5:30-6:30 Social Hour and Cocktail reception 6:30-8:00 Dinner and presentation of 50-year members recognition and presentation of the Hill Award. Approximately at 8:00 p.m. there will be a Lecture by Dr. David Yesair, "Creating a New Biomolecular Enterprise."

The location of the evening's event will be at the Wellesley College Club, located on the campus. Transportation to the campus from Cambridge: MIT-Wellesley Exchange bus runs from MIT to Wellesley.

If you get the commuter rail from South Station or Back Bay, get off at Wellesley Square, it's a short walk to campus.

If you plan to attend and want to be fed, please contact the NESACS Administrative Secretary, Marilou Cashman at [email protected] or Phone 1 800 872 2054

Hope to see many of you soon.

Jean A. Fuller-Stanley Ph.D. Professor and Chair, Chemistry Wellesley College, Wellesley, MA 02481 Phone: 781 283 3224 FAX: 781 283 3642 E-mail: [email protected] Chair-elect 2003 NESACS

95 EDUCATION COMMITTEE REPORT OF THE HIGH SCHOOL SUBCOMMITTEE ON EDUCATION Stephen Lantos, Subcommittee Chair

High School Subcommittee Members

Stephen Lantos Chair Peter Nassiff Avery Ashdown Examination Ruth Tanner Lyman C. Newell Grants David Olney Aula Laudis Society Wallace J. Gleekman Theodore William Richards Award

Avery A. Ashdown High School Chemistry Examination Contest & United States Chemistry Olympiad Team (Ashdown Committee: Peter Nassiff, Chair; Steve Lantos, Wally Gleekman) (Olympiad Section Coordinator: Steve Lantos)

The HS Education Committee continues to sponsor and run the annual Avery Ashdown High School Examination Contest. Since the early 1970s, the exam has increased participation to include over 35 participating schools from across the section with well over 120 students sitting for the exam each spring. After eleven years, High Sschool Sub-Committee Chair Steve Lantos passes on the exam writing responsibility to Peter Nassiff.

Top scorers from the exam are eligible to participate in the United States National Chemistry Olympiad, and though we did not have any competitors to compete for a place on the US Team in 2003, in recent years we've sent students from the section to compete amongst a select group of only 20 students nationwide to vie for a spot on the team. Maybe in 2004 . . .

Cash prizes are awarded to the top five scorers; honorable mention certificates are given to the students earning the top five scores at each of the two levels--first and second year.

The 2003 awardees were: First Prize / Simmons College Prize Ziliang Lin Brookline High School Second Prize (tie) Vineel Kankanala Phillips Academy, Andover Second Prize (tie) Adam P. Rosenfield Lexington High School Fourth Lauren M. Forbes Acton-Boxborough High School Fifth Prize (tie) Evan M. Hoke Wayland High School Fifth Prize (tie) Douglas Hammond Malden Catholic High School

96 Lyman C. Newell Grants (Chair: Ruth Tanner)

The Lyman C. Newell Grants provide financial assistance to high school teachers in the geographical area of the Northeastern Section of the ACS to subsidize the cost of attending the annual summer conference sponsored by NEACT, the New England Association of Chemistry Teachers. The grants are administered by the Newell Grants Committee, all of whom are high school chemistry teachers. The Committee administers the grant process starting with the publicity to the awarding of the grants. The Committee coordinates its activities with the Chair of the Education Committee and the President of NEACT. In 2003, four Newell Grants of $225 each were awarded for the 2003 NEACT Summer Conference which was held in August at Sacred Heart University, Fairfield, CT, to:

Patricia Brandl Medford High School, Medford, MA Lorraine Kelly Hull High School, Hull, MA Diane Paskowski Somerset High School, Somerset, MA Richard Silva East Providence High School, East Providence, RI

Aula Laudis Society (Committee: Dave Olney, Chair; Dick Coombs, Wally Gleekman, Kathy Skelly)

The Section recognizes outstanding secondary school teachers of chemistry by naming them to the Aula Laudis Society at the Annual Education Awards Night conducted in May. In 2003, four area teachers were inducted into the Society; i.e.,

Anne Woodward Lowell High School Jay Chandler Wayland High School Mary Curtis Belmont High School (retired) Jean Avery Chatham High School

Theodore William Richards Award (Committee: Wallace J. Gleekman, Chair; Kenneth Kustin, Carolyn Spodick, Wallace Gleekman, Harry Stubbs)

The Theodore William Richards Awards for Excellence in Teaching of Secondary School Chemistry were awarded to James Miller Bishop Brady High School Ralph Sherwood Chelmsford High School Coretta Tam Newton Country Day School

97 SAMPLE FORMS USED IN HIGH SCHOOL AND COLLEGE MAILINGS / WEB POSTINGS

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

TO: High School Chemistry Teachers FROM: Steve Lantos, Chair, High School Education Committee DATE: February 21, 2003

NOTE: Please refer to the website of the Northeastern Section for Ashdown Examination information and registration forms. The URL is http://www.nesacs.org This year's Avery Ashdown High School Chemistry Examination Contest of the Northeastern Section of the American Chemical Society will take place on SATURDAY, APRIL 5, 2003, starting at 9:00 a.m. at

SIMMONS COLLEGE 300 The Fenway Boston, MA 02115

At Simmons, we will be using rooms in the Science Building which is directly behind the Main College Building. Free parking will be available in the college parking lot located off Avenue Louis Pasteur. Parking permits will be issued at Simmons.

Each high school in the Northeastern Section may be represented by a maximum of five (5) participants selected by their school or teachers. (One alternative may be named on the registration form, but only five students will be tested.) Winners of cash awards and honorable mention awards in previous years are not eligible to compete for Ashdown recognition; however, they may compete to become eligible for the Olympiad Examination. Cash awards will be given to the students with the top five (5) scores. Honorable mention awards will be given to five (5) first- year and five (5) second-year students with the next highest scores. In addition, each winning student will be invited, along with his/her teacher, to be guests of the Northeastern Section at its May, 2003, dinner meeting and will be awarded an appropriate certificate and book. SCORES WILL BE REPORTED TO TEACHERS VIA E- MAIL IF ADDRESSES ARE PROVIDED ON THE TEACHER REGISTRATION FORM.

Top scorers in the Ashdown Examination will be eligible to take the qualifying exam for the Unites States Chemistry Olympiad Team. PLEASE SEE THE GUIDELINES ON THE REVERSE SIDE OF THIS MEMO FOR MORE INFORMATION ABOUT THE ASHDOWN EXAMINATION AND THE INTERNATIONAL CHEMISTRY OLYMPIAD.

Please return the enclosed STUDENT and TEACHER REGISTRATION FORMS by Tuesday, April 1, 2003, to register your students for the Ashdown Exam. Each student should bring #2 pencils to the examination. NON- PROGRAMMABLE CALCULATORS WILL BE PERMITTED FOR THE 2003 EXAMINATION. All other calculating devices are NOT permitted. Along with the enclosed form for registration of students, it is requested that each school send $5.00 per student ($25 maximum) in order to help defray the cost of prizes and awards. The check should be made out to NESACS - Ashdown Exam. (Please DO NOT SEND PURCHASE ORDERS.)

98 Please be certain that your students make careful note of the exact information about the examination since this is not an official function of the colleges involved and few on campus will be aware of essential details. Any questions about the details of the examination should be directed, preferably by e-mail, to: Marilou Cashman Dr. Peter Nassiff Administrative Secretary Science Department 23 Cottage Street or Burlington High School Natick, MA 01760 Burlington, MA 01803 (508) 653-6329 or (800) 872-2054 781-270-2923 e-mail: [email protected] e-mail: [email protected]

Note: This information, with the Guidelines and Registration Forms, can be found on the internet at http://www.nesacs.org

99 2003 AVERY A. ASHDOWN EXAMINATION GUIDELINES 1. Entrants. The Ashdown Examination has traditionally been divided among two populations of students: first- year and second-year/AP level. Difficulty has arisen in the past in defining those students who are taking chemistry as a second-year course but do not follow the AP curriculum and those who are taking a first-year course but do follow the AP curriculum.

It is NOT the intent of the Examination Committee to narrow and define academic guidelines of entrants; the simple goal of the exam is to test for chemical knowledge. Thus, students will be defined as: first-year (a first exposure to chemistry) and second-year (a second-year exposure to chemistry), regardless of an individual's background, course name, or curriculum. We feel this will most fairly include as many as possible in taking the examination.

2. Scoring and Prizes. As before, five (5) cash awards will be given for the top scores of ALL entrants. Duplicate scores in the top five will be considered as two of the five scores. Scoring is determined by raw score. The next five scores for both first and second year will be awarded an Honorable Mention and certificate, regardless of duplicate scores. Recognition will also be given to each teacher. It is strongly felt that students and teachers must be given greater recognition than before.

3. The Exam. The exam will remain with 100 questions. The exam follows somewhat with increasing difficulty; thus, first-year students can recognize limits to their chemical knowledge as the exam progresses.

4. Olympiad. Those successful students wishing to compete in the International Chemistry Olympiad will be selected from the top scores, regardless of level. Should there be a duplicate score, both entrants may be considered. As before, only two students from any school may compete.

5. Other. Non-programmable calculators WILL be permitted. It is felt that as much time as possible during the exam should be spent doing chemistry, not math. Within one week of the exam date, student scores will be mailed to the participating schools notifying teachers of the winners. A breakdown of the range of scores and high scorers will be included along with a distribution of the types of chemistry questions included on this year's examination.

Should there be further questions, please contact the Administrative Secretary by phone or fax at the Section Office (800) 872-2054 or by e-mail - [email protected]

Dates

Registration Deadline for Ashdown Examination: Tuesday, April 1, 2003

Ashdown Exam Saturday, April 5 Simmons College 9:00 a.m.

Note: This information may also be found on the internet at http://www.nesacs.org

100 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

September 11, 2003

To: Chairs of Departments of Chemistry, Chemical Engineering, Biochemistry & Molecular Biology (Colleges and Universities in the Northeastern Section of the American Chemical Society

From: Professor Ruth Tanner, Chair Education Committee of the Northeastern Section of the American Chemical Society

Subject: Applications for Grants-in-Aid for Undergraduate Researchers to Attend the National Meeting of the American Chemical Society, Anaheim, California, March 28 – April 1, 2004

I am pleased to announce the continuation of the Northeastern ACS Section Grants-in-Aid program to assist undergraduates to attend the spring National ACS Meeting and present a paper on their research at the Undergraduate Research Poster Session. The 227th National Meeting will be held in Anaheim, California, March 28 – April 1, 2004.

Grants-in-Aid of $250 will be awarded to each of four undergraduates who are enrolled in the Chemistry, Chemical Engineering, Biochemistry or Molecular Biology Departments in the colleges and universities within the Northeastern Section. One condition of the Grants-in-Aid is that the award must be matched, at a minimum, by the institution.

Two copies of the application form are enclosed for you to give to undergraduate researchers who may wish to apply. Please photocopy if additional forms are needed for your students. In addition, application forms may be obtained from the NESACS web site at http://www.nesacs.org. I will be happy to answer any questions you or your students and faculty might have about the Grants-in-Aid program or the application form. I can be reached at (978) 934-3662; e mail: [email protected].

Enclosed are announcements of the Grants-in-Aid program and the Undergraduate Research Poster Session for you to post and distribute in your Department. I thank you for your help in making the activities of the Section known to your students.

The deadline for receipt of completed applications for the Grants-in-Aid is November 3, 2003. Applicants will be notified of the results by e-mail on November 10, 2003. Abstracts for the Undergraduate Research Poster Session must be received by electronic transmission at ACS National Headquarters by November 25, 2003.

Completed Grants-in-Aid applications are to be sent to: Professor Ruth Tanner University of Massachusetts Lowell Chemistry Department, Olney Hall 265 Riverside Street, Room 520 Lowell, MA 01854-5047

101 Call for Papers Undergraduate Research Poster Session

at the 227th National Meeting of the American Chemical Society

Anaheim, California March 28 – April 1, 2004

The ACS invites undergraduate students to submit abstracts of their research papers for presentation at the Undergraduate Research Poster Session (URPS), which will be part of the extensive programming for undergraduates at this national meeting. Submit your abstract electronically by November 25, 2003 to . Click on the CHED division and then select the URPS site that is appropriate to the subject of your paper. Please follow the directions carefully.

For further information, contact:

LaTrease Garrison ACS Student Affiliates Program 1155 Sixteenth Street, NW Washington, DC 20036 Tel: (800) 227-5558, ext. 6166 e–mail: [email protected]

102 The James Flack Norris and Theodore William Richards

Undergraduate Summer Research Scholarships

Research awards of $3250 will be given for the Summer of 2003. The student stipend is $2750 for a minimum commitment of ten weeks of full-time research work. The remaining $500 of the award can be spent on supplies, travel, and other items relevant to the student project.

Institutions whose student/faculty team receives a Norris/Richards Undergraduate Summer Research Scholarship are expected to contribute toward the support of the faculty members and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions.

Award winners are required to submit a report (~5-7 double-spaced pages including figures, tables, and bibliography) of their summer projects to the NESACS Education Committee by November 8, 2003, for publication in The Nucleus. They are also expected to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2004.

Eligibility: Applications will be accepted from student/faculty teams at colleges and universities within the Northeastern Section. The undergraduate student must be a chemistry, biochemistry, chemical engineering, or molecular biology major in good standing, and have completed at least two full years of college-level chemistry by summer, 2003.

Application: Application forms are available from the NESACS web site at . Completed applications with two photocopies are to be submitted no later than March 26, 2003, to the Chair of the Selection Committee:

Professor Edwin Jahngen Department of Chemistry University of Massachusetts Lowell Lowell, MA 01854

Notification: Applicants will be notified of the results by e-mail on April 18, 2003 followed by written confirmation.

103 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

January 29, 2003

To: Chairpersons of Departments of Chemistry, Chemical Engineering, and Biochemistry (Colleges and Universities in the Northeastern Section of the American Chemical Society)

From: Professor Ruth Tanner (University of Massachusetts Lowell), Chair Education Committee of the Northeastern Section of the American Chemical Society

Subject: Applications for Norris/Richards 2003 Undergraduate Summer Research Scholarships

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards through the promotion of research interactions between undergraduate students and faculty. Research awards of $3,250 will be given for the Summer of 2003, which include a stipend to the student of $2,750 for a minimum of ten weeks of full-time research work; the remaining $500 can be spent on supplies, travel, and other items related to the student project. I am asking for your help to make sure that all those student/faculty pairs who might be interested in applying for support are informed of this program. The deadline for receipt of the completed applications (with two supporting letters) is March 26, 2003. Applicants will be notified of the results on April 18, 2003. Completed application must be submitted to the Chair of the Selection Committee:

Professor Edwin Jahngen University of Massachusetts Lowell Chemistry Department, Room 520 265 Riverside Street, Olney Hall Lowell, MA 01854-5047

Enclosed is an announcement of the program. I ask you to distribute and post it where students and faculty will see it. I would also appreciate your help in making sure that students who might qualify for the scholarships, but who are majors in departments not covered by this mailing, have an opportunity to obtain the information.

Institutions whose student/faculty team receives a Norris/Richards Fellowship are expected to contribute toward the support of the faculty member and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions. Award winners are required to submit a report of their summer projects by November 7, 2003, for publication in The Nucleus, and to participate in the NESACS Northeast Student Chemistry Research Conference in April 2004.

Application forms are available on the NESACS web site at http://www.nesacs.org. If you, your students, or your faculty have any questions about the program or the application, call me at (978) 934-3662, or contact Professor Edwin Jahngen, Chair of the Selection Committee at (978) 934-3693.

Thank you for helping to make this program known and for promoting undergraduate research as a vital part of chemical education.

104 THEODORE WILLIAM RICHARDS AWARD FOR EXCELLENCE IN TEACHING SECONDARY SCHOOL CHEMISTRY

ANNOUNCEMENT OF AN AWARD PROGRAM

The Northeastern Section of the American Chemical Society announces its Year 2003 Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry.

The Award is intended to honor a teacher in the Northeastern Section who, through innovation and dedication, has inspired potential chemists, has communicated chemistry to non-chemists, or has influenced other teachers of chemistry.

Coinciding with this Section's High School Night ceremony in May, the selected teacher will be officially honored and will receive both a $1,500 prize and a Certificate of Recognition.

Anyone, including a prospective awardee, may make a nomination. Colleagues, department heads, principals, students, and former students are urged to consider the criteria upon which the Section will base its selection and to submit the name of a deserving individual.

The criteria for excellence correspond broadly to the effectiveness with which the teacher conveys the principles of chemistry to students and to the influence that the teacher has had on students and on other teachers.

The teacher's effectiveness could be a direct result of innovative and exciting techniques used to help students comprehend and remember chemical concepts and descriptive material. It could be a result of the special effort and dedication that characterizes his or her interaction with students, both academic and extra-curricular. It could also be a result of a particular skill in communicating, especially to students not intending to become chemists, the role chemistry plays in their lives and in society.

The influence of the teacher could be reflected in the way he or she inspires the students or promotes the better teaching of chemistry among other teachers. The influence might have led to students choosing chemistry as a career or might have prompted students to choose an appropriate scientific specialty. It might also have led to other teachers learning to use, through workshops or written material, successful new approaches taken by the nominee to demonstrate laboratory experiments or to solve chemical problems.

The measure of such effectiveness and influence could be reflected in the achievements of his or her students or of students of other teachers who have learned from him or her. It is assumed that many students fortunate enough to have learned chemistry from this teacher could win awards of their own and would go on to become chemists. Such students might have placed high in the Chemistry Olympiad, the Westinghouse Science Talent Search, the Avery Ashdown High School Examination, science fairs, etc. These achievements might very well be more significant than the basic abilities of the student would suggest.

If you know of someone who measures up to these criteria and should be considered for the Award, please complete the attached nomination form and mail by March 31, 2003, to:

Dr. Wallace J. Gleekman 35 Rangley Road West Newton, MA 02465

Note: This information can be found on the website of the Northeastern Section, ACS http://www.nesacs.org

105 NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

March 6, 2003

Dear Madam or Sir:

A set of materials is enclosed relating to the Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry, sponsored by the Northeastern Section of the American Chemical Society. It includes an announcement and nomination form which may be copied as needed.

This Award, as the announcement describes, is for a teacher in the districts covered by the Northeastern Section who has displayed exceptional innovation and dedication in inspiring students in communicating chemical principles and in influencing other chemistry teachers. We would appreciate it if you would bring this Award Program to the attention of both students and faculty in your school.

As you will note, the nomination for this Award may be made by a colleague or a current or former student of the deserving teacher. It is entirely appropriate to renominate someone who was nominated last year.

For your information, the following teachers have received this Award in the past:

Lisa Torres - Lebanon High School Wallace Gleekman - Brookline High School James Johnson - Falmouth High School Carol Murphree - Acton-Boxborough H.S. Richard Coombs - Brookline High School Renee Zimmerman - St. John's Prep School Janice Gepner - The Winsor School Reen Gibb - Brookline High School Jacqueline Arendt - Wayland High School Barbara Hopkins - Oyster River High School Laura Wick Hallowell - Wellesley High School Ronee Krashes - Framingham High School Ann Marie Ladetto - Dartmouth High School Robert Bradley - The Derryfield School Catherine Krueger - Bedford High School Timothy Reed - Weston High School David Olney - Lexington High School Linda Weber - Belmont High School Bette Bridges - Silver Lake Regional High Linda Schleicher - Oliver Ames High School School W. Cary Kilner - Somersworth High School George Martins - Newton North High School Judith Scott Masselam - Lexington High School Monty Wells - Newton North High School Anne Woodward - Lowell High School

We thank you for your cooperation in this matter and draw your attention to the short deadline of March 31, 2003, for receiving the nomination form. Please send nomination forms to:

Dr. Wallace J. Gleekman 35 Rangeley Road West Newton, MA 02465

If you have any questions about the Award Program, please contact me via e-mail at [email protected].

Very truly yours, Wallace J. Gleekman Chair, Award Committee This information can be found on the website of the Northeastern Section, ACS: http://www.nesacs.org

106 Sample Education Committee Items from The Nucleus, 2003 Nominations The James Flack Norris and Theodore William Richards Undergraduate Summer Research Scholarships

The Northeastern Section established the James Flack Norris and Theodore William Richards Undergraduate Sum- mer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty. Research awards of $3250 will be given for the summer of 2003. The student stipend is $2750 for a minimum commitment of ten weeks of full- time research work. The remaining $500 of the award can be spent on supplies, travel, and other items relevant to the student project. Institutions whose student/faculty team receives a Norris/Richards Call for Undergraduate Summer Research Scholarship are expected to contribute toward the support of the faculty mem- Papers bers and to waive any student fees for summer research. Academic credit Northeast Student Chemistry nay be granted to the students at the Research Conference 2003 discretion of the institutions. Saturday, April 26, 2003 Award winners are required to Boston University, Metcalf Cen- submit a report (~5-7 double-spaced ter for Science and Engineering pages including figures, tables, and • Open to undergraduates, graduates bibliography) of their summer projects and postdoctoral fellows in all areas to the NBSACS Education Committee of chemical research ny November 7, 2003 for publication • Student poster presentations invited in The Nucleus. They are also required • Student oral presentations to participate in the Northeast Student Visit the NESACS YCC websife: Chemistry Research Conference http://peopie. bu. edu/nsycc for details, NSCRC) in April 2004. registration, and abstracts submission Eligibility: Applications will be Deadlines: accepted from student/faculty teams at Oral presentations: April 4,2003 colleges and universities within the Poster presentations: April II, 2003 Northeastem Section. The undergraduate student must be a chemistry, biochemistry, chemical engineering, or molecular biology major in good standing, and have completed at least two full years of college-level chemistry by summer, 2003. Application: Application forms are available on the NESACS web site.

107 REPORT OF THE ESSELEN AWARD COMMITTEE - 2003 Arno H. A. Heyn, Chair

The 17th Gustavus John Esselen Award for Chemistry in the Public Interest was presented on April 10, 2003. to Dr. Bruce D. Roth. The Award reception and dinner were held at the Harvard Faculty Club with over 120 people at the dinner. The Award Ceremony and Recipient’s Address, “The Discovery and Development of Lipitor® (Atorvastatin calcium),” were held in the Pfizer Lecture Hall in Mallinckrodt Chemistry Building., with an audience that nearly filled the lecture hall. The Award recipient was introduced by James A. Bristol. The Award was presented to Dr. Roth by Mr. Gustavus John Esselen, III

Dr. Arno Heyn was elected Chair of the Esselen Award Committee for 2003.

The Esselen Award Committee has selected the Esselen Award winner for 2003, whose name will be announced to the NESACS Board at their February meeting, in the February 24th issue of Chemical and Engineering News and the March issue of The NUCLEUS. The Award will be presented on April 10, 2003, at the Harvard Faculty Club, Cambridge, MA.

Dr. E. Joseph Billo was elected Chair of the Esselen Award Committee for 2004, with duties to commence after the Esselen Award events for 2003.

In an effort to keep Esselen Award expenses within budget and make provision for reinvestment of some of the principal for future awards, the Esselen Award Committee voted to limit the expenses to be covered from the Esselen Award funds.

Respectfully submitted, Arno H. A. Heyn, Chair Esselen Award Committee, 2003

Dr. Bruth D. Roth

Esselen Award Recipient 2003

108 NOMINATIONS SOUGHT

GUSTAVUS JOHN ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

The Esselen Award for Chemistry in the public interest is one of the most prestigious honors provided by the Northeastern Section of the American Chemical Society. The award annually recognizes a chemist whose scientific and technical work has contributed to the public well-being, and has thereby communicated positive values of the chemical profession. The Awardee should be a living resident of the United States or Canada at the time of nomination, and the significance of this work should have become apparent within the five years preceding nomination.

The Esselen Award has no limitations with respect to the chemical field in which the nominees are active. Since its inception, the award has been given to the following chemists (see over for subjects):

1987: F. Sherwood Rowland 1994: Kary B. Mullis Mario J. Molina 1995: Howard J. Schaeffer 1988: Alfred P. Wolf Joanna S. Fowler 1996: Roy G. Gordon

1989: Carl Djerassi 1997: Rangaswamy Srinivasan

1990: Thomas J. Dougherty 1998: Kyriacos C. Nicolaou

1991: Jerrold Meinwald 1999: Robert S. Langer Thomas Eisner 2000: William A. Pryor 1992: Bruce N. Ames 2001: Joseph M. DeSimone 1993: James G. Anderson 2002: Ronald Breslow

THE AWARD CONSISTS OF A MEDAL AND A CHECK FOR $5,000. Travel expenses incidental to the conferring of this award will be reimbursed. The award will usually be held in Cambridge, Massachusetts at the April meeting of the Northeastern Section. The Awardee will deliver an address on the subject of the work for which the honor is being conferred, or for work in progress which is also directed to chemistry in the public interest.

TO NOMINATE a candidate please provide statements from two co-sponsors as well as a brief biography of the candidate, a description of the work which has been recognized as communicating the positive values of the chemistry profession, and copies of selected, pertinent articles. Popular news and feature articles should be included as an indication of public interest. Nominations and inquiries should be directed to Dr. Arno Heyn, c/o Karen Piper, 19 Mill Road, Harvard, MA 01451. NOMINATIONS SHOULD BE POSTED NO LATER THAN OCTOBER 15, 2002. Joint nominations are acceptable. The Committee will review the nominations and the award recipient will be notified by the first of February.

109 Invitation to Esselen Award Dinner

The Board of Directors of the Northeastern Section of the American Chemical Society requests the honor of your presence on the occasion of the seventeenth presentation of The Gustavus John Esselen Award for Chemistry in the Public Interest to Bruce D. Roth on Thursday, April 10, 2003

5:30 o’clock 8:15 o’clock Preprandial hour and dinner Award ceremonies Harvard Faculty Club Pfizer Lecture Hall 20 Quincy Street Mallinckrodt Chemistry Laboratories Cambridge, Massachusetts 12 Oxford Street Cambridge, Massachusetts Black Tie Optional

Reply card

The favor of a reply is requested by April 4, 2003

M ______

will ______attend

Please indicate if you prefer a vegetarian entreé ______

110 from the Esselen Award Dinner Program:

Presentation of the

Seventeenth

GUSTAVUS JOHN ESSELEN AWARD

for

CHEMISTRY IN THE PUBLIC INTEREST

BRUCE D. ROTH

Thursday, April Tenth Two Thousand Three Harvard University Cambridge, Massachusetts

111 BRUCE D. ROTH Pfizer Global Research and Development Ann Arbor Laboratories

Bruce D. Roth, Vice President of chemistry t Pfizer Global Research and Development, Ann Arbor Laboratories, was born in Philadelphia, Pennsylvania on February 16, 154. He received his undergraduate education at St. Joseph's College in Philadelphia and his graduate education from Iowa State University where he received the Ph.D. in Organic Chemistry under Dr. George A. Kraus. Following a post-doctoral year at the University of Rochester with Dr. Andrew S. Kende, he joined the Atherosclerosis Chemistry Section of the Parke-Davis Research Division, Warner-Lambert Company, now Pfizer Global R&D.

Dr. Roth's dissertation title was "The total synthesis of antifungal antibiotics" and included the total synthesis of the antifungal, antibiotic (±)-Kalafungin. During his tenure at the University of Rochester in 1981-2, Dr. Roth completed the total synthesis of the insect antifeedant (±)-Ajugarin IV and the anticancer agent (±)-Quadrone. Upon joining Warner Lambert he worked on a project aimed at discovering and developing potent and specific inhibitors of the enzyme HMG-CoA reductase, the rate-limiting enzyme in endogenous cholesterol biosynthesis. At this time, all HMG-CoA reductase inhibitors were derived from natural products produced by microorganisms. Dr. Roth conceived of liver specificity as a means to enhance the efficacy of these drugs, and designed this property into the synthesis of atorvastatin. In July of 1985 the racernic version of atorvastatin (PD 123832) was synthesized and, subsequently, was separated into its two component enantiomers. A chiral synthesis was developed to prepare the active (+)-stereoisomer which was then developed as atorvastatin and is now marketed in the United States under the name Lipitor®. Dr. Roth received the 1997 Warner-Lambert Chairman's Distinguished Scientific Achievement Award for the discovery and development of Lipitor®, the 1999 "Inventor of the Year Award" from the New York Intellectual Property Law Association, Inc., and the 2003 American Chemical Society Award for Creative Invention. In addition to being the inventor of Lipitor, Dr. Roth led the chemistry team involved in the project and was the co- chair of the Atherosclerosis Discovery Team which was responsible for all of the decision-making with regard to the preclinical development of Lipitor®.

Dr. Roth is the inventor or co-inventor of 42 issued U.S. patents and the author or co-author of 48 manuscripts, 35 published abstracts and 8 book chapters and review articles. He is also an Adjunct Associate Professor in the Department of Medicinal Chemistry in the School of Pharmacy of the University of Michigan. He is married with 4 children.

Program

Preprandial Hour and Dinner Harvard Faculty Club Esselen Award Ceremonies Pfizer Lecture Hall Mallinckrodt Chemistry Laboratories Chairman, Northeastern Section John L. Neumeyer The Esselen Award Arno Heyn Bruce D. Roth James A. Bristol Presentation of the Award Gustavus J. Esselen, III Esselen Award Address Bruce D. Roth

“The Discovery and Development of Lipitor® (Atorvastatin calcium) “

The Esselen Award is made possible through an endowment by the EsselenFamily in memory of Dr. Gustavus J. Esselen

5 112 GUSTAVUS JOHN ESSELEN 1888-1952

Born in Roxbury, Massachusetts, Gustavus J. Esselen received his higher education at Harvard, where he was awarded the A.B. (magna cum laude) in chemistry in 1909 and the doctorate in 1912. In that same year he married Henrietta W. Locke, a chemistry graduate at Radcliffe. Their three children are Mrs. Bradford K. Bachrach, Mrs. George B. Hanson and Gustavus John III.

His professional career was devoted to chemical research, first with General Electric Co. in Lynn, Arthur D. Little, Inc. in Cambridge, and Skinner, Sherman and Esselen, in Boston. In 1930 he founded Gustavus J. Esselen, Inc., later known as Esselen Research Corporation. Over the years he successfully solved a variety of problems for industrial clients in such fields as plastics, synthetic fibers, paper, rubber, and glass. Among these was the development of anhydride curing agents for epoxy resins and polyvinyl butyral as an improved material for safety glass, both of which enjoyed considerable commercial success. More than 40 U.S. patents were issued as a result of his research efforts.

Esselen was an active member of the American Chemical Society for 43 years. He served two terms as chairman of the Northeastern Section (1922 and 1923) and was Councilor and Director at the National level. In 1948 he received the James Flack Norris Honor Scroll as "the person who has done most to advance the interests of the Northeastern Section."

He was the recipient of The Modern Pioneer Award from the National Association of Manufacturers in 1940, and in 1950 he was made an honorary member of the American Institute of Chemists in recognition of his services to the professions of chemistry and chemical engineering. He was Chairman of the American Section of The Society of the Chemical Industry of Great Britain, President of the American Council of Commercial Laboratories, Director of the Boston Chamber of Commerce and President of the Rotary Club of Boston.

Esselen's distinguished contributions to chemistry and chemical engineering were in accordance with the highest ethics of these professions; his recognition of the duties of a professional led to his exertion of a wise and beneficent influence on all the professional societies to which he gave so generously of his time and led to his active participation in church and civic activities in the Boston area.

Esselen was a very sensitive person, devoted throughout his life to the fine arts and music. His motto, contained on a tapestry in his office, was a quotation of Richard Wilstatter, "It is our destiny, not to create, but to unveil."

113 PRIOR RECIPIENTS OF THE ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

F. Sherwood Rowland and Mario J. Molina ...... 1987 Discovery of the effect of chlorofluorocarbons on the ozone layer.

Alfred P. Wolf and Joanna S. Fowler ...... 1988 Chemical methods used in positron emission tomography for medical diagnostics.

Carl Djerassi ...... 1989 Contraception and the synthesis of the first birth control drug.

Thomas J. Dougherty ...... 1990 Photodynamic therapy for treatment of malignant disease.

Jerrold Meinwald and Thomas Eisner ...... 1991 Insect Chemistry and Human Welfare

Bruce N. Ames ...... 1992 Understanding the Causes of Aging and Cancer

James G. Anderson ...... 1993 Global Ozone Loss and its Prediction

Kary B. Mullis ...... 1994 The Polymerase Chain Reaction

Howard J. Schaeffer ...... 1995 Nucleosides with Antiviral Activity; Discovery of Acyclovir (Zovirax®)

Roy G. Gordon ...... 1996 Low-Emissivity Glass; Energy Conserving Windows

Rangaswamy Srinivasan ...... 1997 Ablative Photo Decomposition for Micromachining of Polymers and Biological Tissue

Kyriacos C. Nicolaou ...... 1998 Chemical Synthesis and Chemical Biology of Natural Substances

Robert S. Langer ...... 1999 The Development of Unique Polymers for Medical Applications

William A. Pryor ...... 2000 Vitamin E and the Prevention of Heart Disease

Joseph M. DeSimone ...... 2001 Green Chemistry for Sustainable Economic Develoment

Ronald Breslow ...... 2002 Chemistry Lessons from Biology and vice versa

114 REPORT OF THE GOVERNMENT RELATIONS COMMITTEE - 2003 Doris I. Lewis, Chair

Our Section has three active participants in the ACS Joint Board-Council Committee on Chemistry and Public Affairs. Dr. Michael J. Hearn is a committee member and is Chair of the Grassroots Advocacy and Membership Subcommittee. Timothy L. Rose serves on the Awards Subcommittee. Doris Lewis is a committee member. Dr. Hearn and Dr. Lewis attended the committee meeting in Washington and ACS Legislative Summit April 7-9, making several congressional visits. Dr. Rose was prevented from doing so by injuries received in an auto accident, from which he has since recovered.

Dr. Lewis informed the NESACS Board of opportunities for participation in the Legislative Action Network.

Respectfully submitted,

Doris Lewis, Chair

115 REPORT OF THE LONG-RANGE PLANNING MEETING

Northeastern Section AMERICAN CHEMICAL SOCIETY

Administrative Secretary (MA & NH only) Phone or Fax (800) 872-2054 23 Cottage Street Phone or Fax (508) 653-6329 Natick, MA 01760 e-mail: [email protected]

A Long-RangeMeeting Notice Planning Meeting will be held Monday, June 9, 2003 from 5:00 p.m. - 7:00 p.m. at McLEAN HOSPITAL 115 Mill Street Belmont, MA in Room 116 Francis deMarneffe Building (same building is also the Cafeteria and Library)

Light refreshments will be served.

Please notify Marilou Cashman by Thursday, June 5, if you will be attending. [email protected] or (800) 872-2054

Directions to McLean Hospital and a map of the grounds are enclosed. In addition, these items may be found at the following internet sites:

DIRECTIONS: http://www.mcleanhospital.org/map.htm#Directions

MAP OF THE GROUNDS & BUILDINGS: http://www.mcleanhospital.org/map/grounds.html

116 Long-Range Planning Meeting June 9, 2003 5:00 p.m. - 7:00 p.m. McLean Hospital, Belmont

Minutes of the Meeting

The meeting was called to order at 5:00 p.m. with J. Neumeyer in the Chair.

Some suggestions: Emphasize community outreach, NCW, active high school outreach, lecture at Museum of Science.

· Public Relations Committee -- who are the members? · Were articles sent to the local newspapers of the High School Recipients?

117 · Mukund Chorghade is supposed to be the PR Chair; has he been trained by National? · Ask Mukund if any articles were sent about the Education Night Awards · Put article in The Nucleus looking for interested PR persons! · Ask local papers to send reporters to NESACS events (unlikely) · Ask for reporters at each college/university to send weekly/monthly reports · Wally suggests sending letters to recipients' school superintendent to release to media · Send monthly meeting notice to Globe “Events Calendar”, and other newspapers. · Public Relations Issues are unresolved!!!!!!!!!!!!!

Esseleen and Richards Awards Committees: Chairs and committee members take office immediately, not in January.

Handbook: Material requested by Karen Piper. This will be an “operating manual”--operations of various committees and officers etc. It is 60% complete.

The ACS Handbook (Green Monster) for Local section officers is now on CD

Meeting adjourned approximately 7:15 p.m.

Notes taken courtesy of Jean Fuller-Stanley and Don Rickter

118 MEDICINAL CHEMISTRY GROUP Annual Report 2003 Pamela Nagafuji, Chair

The Medicinal Chemistry Group (MCG) of the NESACS successively held 3 technical medicinal chemistry mini-symposia this year with an average of 91 attendees per meeting. This year (2003) the topics covered : · genomics · design of protease inhibitors · recent advances in cancer treatment

These symposia continue to provide a means for area NESACS scientists to present their research, to foster collaborations, to further professional development and to pursue personal scientific interests in areas outside their expertise and are open to the general public. For the year 2002 the MCG demographically represented approximately 50% of the sections 6,592 members with an annual operating budget of $7,500.

The following is a description of the three symposia held this year.

· A joint symposium was held with the Swiss House for Advanced Research and Education and the MCG on June 5, 2003. Dr. Dalia Cohen, Vice President and Global Head Functional Genomics at the Novartis Institutes of Biomedical Research (NIBR), Cambridge, MA gave the lecture “From Genome to Therapy.”

· The October 7, 2003 symposium, “The Design of Selective Inhibitors” featured talks on specific inhibition of cysteine and serine proteases by medicinal chemists from Novartis, GlaxoSmith Klein, and Pfizer. Edwin Villhauer from Novartis spoke about the inhibition of DPP-IV, a serine protease, using synthesized 2-Cyanopyrrolidines for the potential treatment of type II diabetes. Dennis Yamashita described osteoclast specific Cathspin K inhibitors developed in his labs at GSK and Peter Dragovich presented Pfizer’s discovery of Rupintivir a rhinovirus 3C protease inhibitor with potential to treat SARS. John Tally from Microbia recounted his role as the lead inventor of Celebrex™, the commercially available NSAID (non-steroidal anti-inflammatory drug) that is the first selective inhibitor of COX-2.

· The December 11th 2003 meeting, “New Approaches in the Treatment of Cancer” comprised strategies using folates, boronic acids, humanized antibodies and inhibition of protein kinases to selectively inhibit cancer cell growth. Richard Henson spoke about Genentech’s monoclonal antibody Pertuzumab which prevents HER-2 heterodimerization and subsequent phosphorylation and is effectively used to treat ovarian cancer. Andre Rosowsky disclosed the development of PT523, a folate antagonist recently approved for Phase I clinical trials and recounted the molecular modifications required to inhibit polyglutamation, while markedly enhancing binding affinity for the reduced folate carrier, the membrane-anchored protein responsible for active transport of both serum folates and classical antifolates into cells. Julian Adams’ lecture was a chronicle of the development of Velcade™, the first proteasome inhibitor to be approved for the treatment of multiple myleoma. Paul Manley’s contributions at Novartis led to the advancement of0 Gleevec™ the first specific tyrosine kinase inhibitor which prevents phosphorylation catalysed by Bcr-Abl and is a highly effective therapy for chronic phase CML(Chronic myelogenous leukemia).

119 MED-CHEM FLYER: NESACS/SHARE SYMPOSIUM

Joint Symposium of the Swiss House for Advanced Research and Education (SHARE) and the Medicinal Chemistry Group of the Northeastern Section of the American Chemical Society (NESACS)

Thursday, June 5, 2003

Consulate of Switzerland, SHARE, 420 Broadway, Cambridge, MA 02138

6:30 pm Welcome and Introduction, Dr. Christoph von Arb, Director, Consul, Consulate of Switzerland, SHARE, Cambridge, MA

7:00 pm “From Genome to Therapy”, Dr. Dalia Cohen, Vice President and Global Head Functional Genomics at the Novartis Institutes of Biomedical Research (NIBR), Cambridge, MA

8:00 pm Q & A Session followed by a Cocktail Hour with Refreshments and Hors d’Oeuvres

For RSVP, please call or fax Marilou Cashman at (800) 872-2054 or e-mail at [email protected] no later than noon, June 2, 2003. Contributions to offset the cost for food and drinks (alcoholic and non- alcoholic) would be greatly appreciated. Please send contributions to the NESACS office: c/o Marilou Cashman, 23 Cottage St., Natick, MA 01760

SHARE is located at 420 Broadway, close to Harvard Square in Cambridge. As parking is limited in the neighborhood, we suggest that you use public transportation. Directions can be found at: http://www.shareboston.org/info/directions.shtml

DALIA COHEN

Dalia Cohen, Ph.D., is Vice President and Global Head of Functional Genomics at Novartis Institutes. She also serves on the Board of Directors for the SNP Consortium and is an Adjunct Professor at the UMDNJ-Robert Wood Johnson Medical School in New Jersey, US.

From 1997 to 1998, Dr. Cohen held the position of Executive Director and Senior Expert, Molecular and Cellular Biology, at Novartis Pharma Research, prior to which she was an associate in the Oncology Department from 1992 to 1996. Between 1986 and 1992, she worked as a Research Associate in the Department of Molecular Pharmacology at the Albert Einstein College of Medicine.

Dr. Cohen received her Ph.D. in cell biology from the Faculty of Medicine at Technion, Israel Institute of Technology, and has published more than 50 scientific articles.

120 MEETING NOTICE: MED-CHEM GROUP

Medicinal Chemistry Group Meeting

The Meeting of the Northeastern Section Of the American Chemical Society Medicinal Chemistry Group

Symposium: The Design of Selective Inhibitors

Tuesday, October 7, 2003 MIT Faculty Club; 50 Memorial Dr., Cambridge, MA

3:00 pm Refreshments 3:15 pm Edwin Villhauer, Novartis, East Hanover, NJ N-Substituted Glycyl 2-Cyanopyrrolidines as a New Family of DPP-IV Inhibitors and their Potential in Type II Diabetes. 4:15 pm Dennis Yamashita, Glaxo SmithKline, Collegeville, PA Peptidomimetic Inhibitors of the Osteoclast-Specific Cysteine Protease Cathepsin K. 5:15 pm Peter Dragovich, Pfizer Global R&D, San Diego, CA Discovery of Rupintrivir (AG-7088): A Potent and Selective Human Rhinovirus 3C Protease Inhibitor. 6:15 pm Reception 6:45 pm Dinner 8:00 pm John Talley, Microbia, Cambridge, MA Discovery of Celebrex.

Dinner reservations should be made no later than noon, Sept. 30. Please call or fax Marilou Cashman at (800) 872-2054 or e-mail at [email protected]. Please specify: Chef's Choice or Vegetarian. Reservations not cancelled at least 24 hours in advance must be paid. Members, $28.00; Non- members, $30.00; Retirees, $15.00; Students, $ 10.00.

THE PUBLIC IS INVITED.

Anyone who needs special handicap services or transportation, please call Marilou Cashman a few days in advance so that suitable arrangements can be made.

121 FLYER: NESACS/MED-CHEM SYMPOSIUM

December Meeting

The 847th Meeting Northeastern Section of the American Chemical Society Northeastern Section of the American Chemical Society

Symposium: New Approaches in the Treatment of Cancer

Organized by the Medicinal Chemistry Section of the Northeastern Section, American Chemical Society

Thursday - December 11th, 2003 Radisson Hotel - 15 Middlesex Canal - Woburn, MA

3.00 pm Refreshments 3.30 pm History of the Development of PT523--A Potent Folate Antagonist Recently Approved for Clinical Trial Andre Rosowsky, Dana-Farber Cancer Institute, Boston, MA 4.30 pm Proteasome Inhibitors: Discovery and Development of VelcadeTM (Bortezomib, PS-341) Julian Adams, Infinity Pharmaceuticals, Cambridge, MA 5.30 pm Social Hour 6.30 pm Dinner 7:45 pm Targeted Drugs for Cancer Therapy. Gleevec: A New Paradigm Paul Manley, Novartis Pharma Ltd., Basel, Switzerland

Dinner reservations should be made no later than 12:00 noon on Thursday, November 5. Please call Marilou Cashman at (800) 872-2054 or (508) 653-6329 or respond by e-mail to [email protected]. Reservations not canceled at least 24 hours in advance must be paid. Members, $28.00; Non-members, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made.

Directions

A. From Boston - Cambridge - Points North: Take Route I-93 to Route 95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). *After about 500 feet at the traffic light, turn right into Middlesex Canal Street to the hotel entrance. B. From the West: Take Route 95/128 North to Exit 35 South (Route 38 - Main Street. Follow directions from * above. THE PUBLIC IS INVITED

122 Paul W. Manley Targeted drugs for cancer therapy. Gleevec: a new paradigm

The goal of treating cancer by eliminating only neoplastic cells, without effecting normal cells, has until recently been elusive. Cancer comprises of over 200 diseases and although many of these share mechanisms of carcinogenesis, different types of neoplasm differ in their pathophysiology and underlying biochemistry. To exploit these differences molecular biology and genetics have been used to identify and characterise components of the mitogenic signaling pathways of normal and neoplastic cells, thereby providing much insight into the biochemistry of many cancers. From this understanding, together with epidemiological evidence, protein kinases are implicated as being crucial to the generation and maintenance of the transformed phenotype in many types of tumour. Therefore a key to increasing the responsiveness of a particular tumour type to a therapeutic approach, is to phenotype the neoplasm according to the expression of a particular target and then to direct therapy against that target. With such an approach coupled with the ability of researchers to design tyrosine kinase inhibitors which are both effective and suitable for chronic therapy, we are becoming increasingly successful in specifically targeting cancer cells. Chronic myelogenous leukaemia (CML) results from a reciprocal chromosomal translocation in haematopoietic stem cells (HSCs) which leads to formation of the BCR-ABL hybrid gene. This gene encodes the oncogenic Bcr-Abl fusion protein, the kinase activity of which is constitutively activated. The unregulated phosphorylation catalysed by Bcr-Abl is responsible for the transformation of HSCs to produce a phenotype exhibiting deregulated clonal proliferation., enhanced mobility and decreased apoptosis. Gleevec (imatinib; STI571) was designed to target the ATP binding site of the c-Abl kinase and is a highly effective therapy for chronic phase CML. Despite the efficacy of Gleevec, many advanced stage patients in blast crisis relapse. Recent studies show that many relapsed patients carry point mutations in the kinase domain of Bcr-Abl, which render the enzyme resistant to inhibition by Gleevec. This lecture will describe the drug discovery process for Gleevec and detail the molecular interaction of the drug with its target, thereby rationalising drug resistance on a molecular level.

Paul W. Manley was born in Bristol (U.K.) and awarded a Ph.D. in organic chemistry from University of Liverpool in 1979. He first joined Searle Research & Development (Bucks., U.K.) as a medicinal chemist, after working on antifungal and antibacterial agents, he took responsibility for the Platelet and Vascular Dysfunction Program, focusing on thromboxane synthase inhibitors, type-3 phosphodiesterase inhibitors and PAF antagonists. In 1986 he moved to Sandoz (Basel, Switzerland) to work on potassium channel activators and type-4 phosphodiesterase inhibitors, for use in cardiovascular and asthma therapy. In 1998, he joined the Oncology Research Department of the newly formed Novartis, to work in the area of tyrosine kinase inhibitors and currently leads a program directed towards anti-leukaemia drugs.

Peer reviewed publications: 48 Patents: 30

123 Julian Adams Proteasome Inhibitors: Discovery and Development of Velcade™(Bortezomib, PS-341).

VELCADE TM is the first proteasome inhibitor to be approved for the treatment of cancer, specifically, multiple myleoma. The lecture will chronicle the development of VELCADE, which is still under intense investigation in numerous malignancies, with specific focus on the role that Cap CURE played in the development and support of the concept of proteasome inhibition. Without the vision of the scientific advisory group, and specifically Howard Soule and Christopher Logothetis, the first trial in prostate cancer, would have been significantly delayed, and it is conceivable that the drug may have been dropped altogether. The talk will focus on the persistence and dedication of the people involved, as well acknowledge the risk and challenges in developing new therapies. This is still a work in progress, and it is hoped that the collaborative nature of industry, advocacy groups, and academic science and medicine should be the modus opperendum for future discoveries and drug development to eradicate cancer and other life threatening illnesses.

Julian Adams recently joined Infinity Pharmaceuticals, Inc. as Chief Scientific Officer. Prior to Infinity, he served as Senior Vice President, Drug Discovery and Development at Millennium Pharmaceuticals, Inc. (NASDAQ MLNM). Dr. Adams joined Millennium Pharmaceuticals, Inc. in December of 1999 following the Company's merger with LeukoSite. He brought to Millennium the recently approved drug VELCADETM, a proteasome inhibitor for cancer therapy and led drug discovery teams in producing drug candidates through lead optimization for preclinical development in both the U.S. and U.K. At LeukoSite, he served as Senior Vice President of Research and Development since July 1999. From 1994 to 1999, he served as Executive Vice President of Research and Development at Proscript, Inc., a biopharmaceutical company. In 1987, he joined Boehringer Ingelheim where he served in various positions including Director of Medicinal Chemistry. At Boehringer, he successfully discovered the drug Viramuneâ, for HIV. From 1982 to 1987, he was a Medicinal Chemist at Merck in Montreal. Dr. Adams received a B.S. from McGill University and a Ph.D. from the Massachusetts Institute of Technology in the field of synthetic organic chemistry. He also received many awards, most recently the 2001 Ribbon of Hope Award for PS- 341 from the International Myeloma Foundation. Dr. Adams is an inventor of over forty patents and has authored over a hundred papers and book chapters in peer reviewed journals.

Andre Rosowsky History of the Development of PT523, A Potent Folate Antagonist Recently Approved for Clinical Trial

Nonpolyglutamatable analogs of classical antifolates like aminopterin (AMT), methotrexate (MTX) are potentially of therapeutic interest for the treatment of solid tumors that are inherently refractory, or have an acquired resistance, to MTX as a result of decreased expression of the enzyme folyl gpolyglutamate synthetase (FPGS), which has nearly absolute specificity for folate and antifolate substrates with an L-glutamate side chain. An interesting class of highly cytotoxic antifolates has been developed, in which the normal side chain of classical antifolates is replaced by a dhemiphthaloyl- L-ornithine side chain. This simple molecular modification doesn't allow polyglutamation, and yet markedly enhances binding affinity for the reduced folate carrier, the membrane-anchored protein responsible for active transport of both serum folates and classical antifolates into cells. These analogues are also exceedingly potent competitive inhibitors of dihydrofolate reductase (DHFR), the target enzyme for AMT and MTX, and as one would expect, are very potent inhibitors of tumor cell growth in culture. Most importantly, their effect on cell proliferation is independent of the presence or absence of cellular FPGS activity, and is much less dependent than classical antifolates on the concent-ration of exogenous reduced folate cofactors Pharmacokinetic and toxicologic studies on the lead compound of the series, Na-(4-amino-4-deoxypteroyl)-Nd-hemiphthaloyl-Lornithine (PT523), were recently completed under the auspices of the NCI, and the first Phase I trial is scheduled to begin shortly.

Andre Rosowsky graduated from the University of California at Berkeley, with a B.S. degree in Chemistry, and from the University of Rochester, with a Ph.D. degree in Organic Chemistry. After a year at Harvard University as an NSF Post- doctoral Fellow with Professor E. J. Corey, he joined the Children's Cancer Research Foundation (now

124 the Dana-Farber Cancer Institute) as a Research Associate. In 1987 he became an Associate Professor in the Division of Cancer Pharmacology at the Dana-Farber Cancer Institute and the Department of Biological Chemistry and Pharmacology at Harvard Medical School. For a number of years he was also on the adjunct faculty at Northeastern University, where he taught evening classes in the College of Pharmacy and Allied Health Professions. He is a former Chairman of the Medicinal Chemistry Group of the ACS Northeastern Section, and for several years represented the Northeastern Section in the ACS National Council. He has served on two NIH study sections, and has more than 200 publications in peer-reviewed journals.

REPORT OF THE MEMBERSHIP COMMITTEE Michaeline Chen, Chair

In 2003, "Welcome New Member" letters were sent to 1017 new members. The dates and number of letters are listed below:

Date No. of Letters

February 26, 2003 123 March 27, 2003 137 April 25, 2003 232 July 27, 2003 166 August 22, 2003 94 September 26, 2003 118 November 28, 2003 147

Total 1017

The following individuals were of great assistance: Mrs. Karen Piper, Business Manager of The Nucleus, supplied the labels for the new members' roster. The ACS envelopes were from our Section Secretary, Marilou Cashman. Our Editor of The Nucleus, Dr. Arno Heyn, placed a short note in the 2003 issues of The Nucleus to invite new members to our monthly meeting and dinner. The number of new members who came to dinner ranged from 2-11. Not as many new members took advantage of the Section's invitation to attend the dinner meetings at the Section's expense as I had expected.

The purpose of the membership committee is to welcome new members, assist and support our members in need and refer them to the appropriate resources, monitor membership in our Section and recommend chemists and chemical scientists for membership. More new members are interested in employment opportunities and job information. Some are interested in National Chemistry Week; others are interested in Government Relations, Hospitality and other functions. A survey of new members was conducted and the results appear in Appendix 3-A of the 2003 Annual Report.

The committee should consist of 2-4 members and meet at least once a year (maybe by e-mail) and work very closely with the Editor of The Nucleus, the Section Secretary, Business Manager of The Nucleus, and the Hospitality Committee.

A copy of my welcome letter to new members is attached.

Michaeline F. Chen, Chair, Membership Committee, NESACS

125 Sample Welcome Letter to New Members

26 September 2003 Dear Colleague,

Congratulations on your joining the American Chemical Society and its Northeastern Section. Welcome aboard! We intend to make sure your decision to join was a wise one. We also provide you with a broad range of services and opportunities to help you personally and professionally.

I would like to invite you to be a guest of our section at the next dinner meeting on Thursday, October 9, 2003. at Wellesley College, 106 Central St. Wellesley, MA (Rte.16) Wellesley College Club. 5:30pm Social hour and dinner 8:00pm Evening meeting: Speaker: Dr. David Yesair (BioMolecular Prod.) “Creating a New Biomolecular Enterprise”

For dinner reservations, please contact our section secretary Marilou Cashman at 1-800-872-2054 or 508- 653-6329, or E-mail: [email protected], on or before the 2nd October. and let her know that you are a new member or a new Local Section member. If you cannot make it this time, you may join us at one of our monthly dinner-lecture meetings of your choice in the future. Our dinner-lecture meetings are usually held on the second Thursday of each month (September through May). Social hour is at 5:30 pm where a table of Career Services Aids and literature will be available. Dinner is at 6:30 p.m. with a guest speaker to follow. The lectures are on a drop-in basis, but reservations are necessary for the dinner.

Information about our monthly meetings will be provided through The Nucleus, our monthly publication. Have you received a copy of The Nucleus? If not, please call the Business Manager of The Nucleus, Karen Piper at 978-456-8622 or Email [email protected].

Once again, welcome to ACS and the Northeastern Section!

Sincerely yours,

Michaeline F. Chen

Chair, Membership Committee Northeastern Section, ACS e-mail: [email protected] or [email protected] 529 Grove Street Needham, MA 02492-1009 Tel: 781-235-5201 from The Nucleus

126 REPORT OF NATIONAL CHEMISTRY WEEK - 2003 Christine Jaworek, Chair

Christine H. Jaworek, Chair National Chemistry Week Northeastern Section, ACS

127 Report printed in The Nucleus, September 2003

NERM 2003 Saratoga Springs, NY - June 15 - 18, 2003 By Morton Z. Hoffman, Boston University;, NESACS Representative to the Northeast Regional Steering Committee

The 31st Northeast Regional Meeting of the American Chemical Society, hosted by the Eastern New York Section, was held in Saratoga Springs on June 15—18. Organized by General Chair Tony Noce (MWH Americas) and Program Co-chairs Susan Hayes (Starfire Systems) and Steve Tysoe (General Electric Global Research Center), the meeting attracted nearly 500 chemists, including about 50 undergraduate students. With corporate support from Albany Molecular Research, General Electric Global Research Center, Starfire Systems, and MWH Americas, and academic support from Union College, the program featured 200 oral and poster presentations, including 26 undergraduate research posters, a wide range of symposia, workshops for students and educators, and a chemical exhibition.

Highlights of the meeting included the presentation of the Buck-Whitney Award of the Eastern New York Section to Thomas Szyperski (SUNY-Buffalo), the Northeast Regional Industrial Innovation Awards to Steven Brickner, Michael Barbachyn, Douglas Hutchinson, and Peter Manninen (Pfizer; Groton, CT), and William Pfefferle (Precision Combustion; New Haven, CT), and the Northeast Regional Award in High School Chemistry Teaching to Sally Mitchell (East Syracuse-Minoa Central High School; East Syracuse, NY). The Eminent Scientist Lecture was presented at a Student Affiliates-Women Chemists Committee luncheon by Linda Schadler (Rensselaer Polytechnic Institute). This author presented a workshop with Barbara Stewart (University of Maine) on “The Peer-Led Team Learning Model” in the symposium on trends and innovations in undergraduate education. Important symposia were offered on light emission, the chemistry of the origins of life, forensics and the 9/11 attacks, nanotechnology, biosensing, and parallel synthesis.

Chemists and engineers from the Northeastern Section who made presentations at NERM include Jack Szostak (Massachusetts General Hospital), Thomas Pochapsky (Brandeis University), Francesco Stellacci (MIT), Tao Deng (MIT), Deli Wang (Harvard University), Martin Polz (MIT), Michael Hearn (Wellesley College), Gary Weisman (University of New Hampshire), Glen Miller (University of New Hampshire), John Porco (Boston University), Li Deng (Brandeis University), Timothy Jamison (MIT), and Morton Hoffman (Boston University).

Ruth Tanner (University of Massachusetts Lowell) served as the facilitator at the meeting for the Division of Chemical Education, and Howard Mayne (University of New Hampshire) represented the previous NERM in 2001 as its General Chair. Also in attendance were the candidates for ACS President-Elect, Michael Strem (Strem Chemicals, Inc.) and William Carroll (Occidental Chemicals Corporation); also present were ACS President Elsa Reichmanis (Lucent Technologies), and Anne O’Brien (Wyeth Research, Retired), ACS District I Director.

The Northeast Regional Steering Committee voted to proceed with the incorporation of the “Northeast Region of the American Chemical Society,” following the trend of other ACS regions around the country in order to ensure the financial continuity and institutional memory of their regional meetings. The Committee examined the proposed bylaws of incorporation, which will be reviewed again at the Fall ACS meeting in New York.

The next NERM, to be hosted by the Rochester Section, will be held in Rochester, NY, on October 31 -November 3, 2004; for details see . NERM 2005 will be hosted by the Western Connecticut Section at Sacred Heart University, Fairfield, CT, on July 14 - 17, 2005. The sites for NERM 2006 and 2008 are under discussion. Because of the Fall ACS National Meeting in Boston in 2007, there will be no NERM that year.

The Nucleus September 2003

128 REPORT OF THE NOMINATING COMMITTEE - 2003 Morton Z. Hoffman, Chair

The Nominating Committee was chaired by Dr. Morton Z. Hoffman, immediate Past-Chair of the Northeastern Section. The following are the results of the balloting for the 2003 ACS officers of the Northeastern Section. There were a total of 653 ballots counted..

NESACS ELECTION RESULTS - 2003 BALLOT

Name Votes Result Position Term

Amy E. Tapper 411 Elected Chair-Elect 1 year Ernest V. Groman 196 Chair-Elect

Michael Singer 535 Elected Secretary 2 years

Joseph A. Lima 534 Elected Trustee 3 years

Catherine E. Costello 397 Elected Councilor 3 years Dorothy J., Phillips 353 Elected Councilor 3 years Julia H. Miwa 333 Elected Councilor 3 years Patricia A. Mabrouk 320 Elected Councilor 3 years Michaeline F. Chen 316 Elected Councilor 3 years Arno H. A. Heyn 306 Elected Alternate Councilor 3 years. Alfred Viola 269 Elected Alternate Councilor 3 years. Howard R. Mayne 258 Elected Alternate Councilor 3 years. Barbara G. Wood 257 Elected Alternate Councilor 3 years. Wallace J. Gleekman 239 Elected Alternate Councilor 3 years. Michael Singer 235 Lowell H. Hall 201 J. Donald Smith 190 Mark Froimowitz 180 David Warr 143

Sarah A. Iacobucci 364 Elected Director-at-Large 3 years Stephen Lantos 271 Elected Director-at-Large 3 years Henry Brown 234 Robert S. Umans 193

Dean E. Wilcox 311 Elected Nominating Committee 1 year Patrick M. Gordon 278 Elected Nominating Committee 1 year Myron S. Simon 266 Donald O. Rickter 237

William Klemperer 386 Elected Esselen Committee 4 years Robert S. Langer 370 Elected Esselen Committee 4 years Mukund S. Chorghade 216 Martin Idelson 165

Stephen J. Lippard 375 Elected Richards Committee 4 years Gary R. Weisman 280 Elected Richards Committee 4 years Amir H. Hoveyda 245 Thomas D. Tullius 232

129 REPORT OF THE NORRIS AWARD COMMITTEE - 2003 Frederick D. Greene, Chair

The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry is presented annually by the Northeastern Section to an educator who is both an excellent classroom teacher and whose professional activities have had a wide-ranging effect on chemical education. The committee of peers who selects the award recipient consists of elected members from the Northeastern Section and external members chosen by the committee, one of whom is the Editor of the Journal of Chemical Education.

After studying the nomination materials the committee met via conference call in late Spring to select the awardee. As is often the case, the committee was presented with a number of outstanding chemical educators who had been nominated, making the choice a difficult one.

The 2003 award was presented to David N. Harpp, Sir William C. Macdonald Professor of Chemistry at McGill University, Montreal, Canada, at a dinner meeting on November 13, 2003. The citation which was presented to Professor Harpp may be found immediately following this report.

Respectfully submitted, Frederick D. Greene, Chair

Committee members for 2003: - Professor Frederick Greene (ret.), Massachusetts Institute of Technology - Professor Robert Umans, Boston University - Professor Howard R. Mayne, University of New Hampshire - Professor Marietta Schwartz, University of Massachusetts Boston - Professor Jerry Mohrig, Carleton College - Professor Mary Virginia Orna, College of New Rochelle - Professor John W. Moore, University of Wisconsin, Editor, Journal of Chemical Education

130 Citation Presented to Professor David N. Harpp The Northeastern Section of the American Chemical Society confers the fifty-second James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry on David N. Harpp McGill University - Montreal, Quebec, Canada In recognition of a career exemplifying excellence in chemical education

You are honored with this award because of the esteem in which you are held by those whom you have taught and by colleagues likewise devoted to education. Your passion for chemistry and education manifests itself in your classroom, with your research group, as advisor and mentor, in your writing, in your interactions with colleagues at many levels, and in your achievements in bringing chemistry to the larger public. Your knowledge and enthusiasm for chemistry and your extraordinary ability to communicate this to others have generated a host of intellectually excited students and teachers. You have notably enriched the heritage and future of chemical education.

Frederick D. Greene November 13, 2003 John L. Neumeyer Chair, Norris Award Committee Chair, Northeastern Section

131 from the Norris Award Dinner Program:

PROGRAM Holiday Inn Newton, MA

5:30 P.M. Social Hour 6:30 P.M. Dinner 7:45 P.M. Norris Award Ceremonies

John L. Neumeyer Chair, Northeastern Section, Presiding

James Flack Norris Myron S. Simon

Introduction of Award Recipient Joseph A. Schwarcz McGill University, Montreal, Canada

Presentation of Award Frederick D. Greene Chair, Norris Award Committee

Norris Award Address "Communicating Chemistry -- from Large Classes to the Larger Public"

David N. Harpp McGill University, Montreal, Canada

Reception in honor of Professor Harpp

132 from The Nucleus

Pictures from the James Flack Norris Award Dinner November, 2003

Joseph A. Schwarcz - Introducer and former Norris Award Winner

Myron S. Simon - Archivist spoke on James Flack Norris

John L. Neumeyer NESACS Chair, 2003

David N. Harpp McGill University Norris Award Winner 2003

David N. Harpp, Awardee John L. Neumeyer, NESACS Chair Frederick D. Greene, Chair of Norris Award Committee

133 REPORT OF THE PROFESSIONAL RELATIONS COMMITTEE - 2003 Submitted by Truman S. Light, Arlene W. Light and Mukund Chorghade

Truman and Arlene Light attended both National Meetings (New Orleans and New York) actively participating in the CEPA Committee work and its subcommittee on Employment Practices. Mukund Chlorghade also attended these meetings and worked extensively with the ACS Department of Career Services in reviewing resumes and conducting mock interviews at National and Regional meetings and also consulted with candidates by telephone, fax and e-mail.

A job seeking seminar for Framingham State College was scheduled and postponed several times and is still pending. Chorghade arranged for publication of a seminal 18-page Employment Guide document in the NUCLEUS.

Copies of the ACS National Employment Guides: The Interview Handbook, Tips on Resume Preparation, Guide for Foreign Chemists have been procured for distribution at the Monthly Northeastern Section Meetings along with Employment Counseling ‘on the spot’.

Assistance is being given to the Chair-elect in planning the annual October Professional Relations meeting, which includes presentation of 50-year pins, and the Henry Hill Award for Outstanding Local Service and a speaker pertinent to Professional Relations activities.

REPORT OF THE CHAIR–ELECT / PROGRAMS - 2003 Jean Fuller-Stanley

As Program Chair, the Chair–Elect organized those monthly meetings of the Section (speakers, venues, etc.) that were not otherwise within the purview of the special awards committees (Esselen, Norris, Richards) and the Medicinal Chemistry Group.

January 9, 2003 No. attended: 70 Speaker: Dr. Leslei E. Orgel (Salk Institute, LaJolla, CA) Title: “The RNA World and the Origin of Life” Location: MIT Faculty Club, Cambridge, MA

February 13, 2003 - Joint Meeting with Younger Chemists Committee (YCC) No. attended: 72 Speaker/NESACS Meeting: Dr. Iona Black (Yale University) Title: “An Investigation of Bonding in Selected Platinum (II) Complexes ” YCC Program: "YCC Symposium - Alternative Careers for Chemists" Speakers: Jack Cunniff (Thermo Finnigan, Regional Sales Manager) Melissa Huang (Rhodia Chirex, Manager--Business Development) Darlene Vanstone (Geltex Pharmaceuticals, Senior Patent Counsel) Two additional speakers Location: Holiday Inn, Newton, MA

March 13, 2003 No. attended: 60 Speaker: Prof. Felice Frankel (MIT) Title: "Envisioning Science; Making Good Science Look Good” Location: Wellesley College

134 April 10, 2003 (Esselen Award) No. attended: 122 Speaker: Dr. Bruce D. Roth (Pfizer Global Research Development, Ann Arbor Laboratories) Recipient of the Gustavus J. Esselen Award for Chemistry in the Public Interest Title: “The Discovery and Development of Lipitor® (Atorvastatin Calcium)” Location: Harvard Faculty Club, Cambridge, MA

May 8, 2003 - Education Awards Program No. attended: 115 Speaker: Dr. Guy A. Crosby (Consultant, writer, lecturer on food & nutrition chemistry) Title: “Recent Developments in the Chemistry of Nutrition and Their Impact on Human Health” Location: Boston University, Boston, MA

September 18, 2003 No. attended: 62 Speaker: Dr. Patrick D. McDonald (Waters Corp.) Title: “Evolution of HPLC: An Insider's View” Location: Merrimack College, No. Andover, MA

October 9, 2003 No. attended: 60 Presentation of Henry A. Hill Award for Service to the Local Section to Dr. Doris I. Lewis Presentation of Certificates to 50-Year ACS Members Speaker: Dr. David W. Yesair (BioMolecular Products) Title: “Creating a New Biomolecular Enterprise” Location: Wellesley College

November 13, 2003 (Norris Award) No. attended: 85 Speaker: Prof. David N. Harpp (McGill University, Montreal, Canada) Recipient of the James Flack Norris Award for Outstanding Achievement in Teaching Chemistry Title: “Communicating Chemistry - from Large Classes to the Larger Public” Location: Holiday Inn, Newton, MA

December 11, 2003 - Joint Meeting with Medicinal Chemistry Group No. attended: 61 Symposium: New Approaches in the Treatment of Cancer Speakers: Andre Rosowsky (Dana-Farber Cancer Institute, Boston) History of the Development of PT523--A Potent Folate Antagonist Recently Approved for Clinical Trial Julian Adams (Infinity Pharmaceuticals, Cambridge) Proteasome Inhibitors: Discovery and Development of Velcade™ (Bortezomib, PS-341) Paul Manley (Novartis Pharma Ltd., Basel, Switzerland) Targeted Drugs for Cancer Therapy. Gleevec: A New Paradigm Location: Radisson Hotel, Woburn, MA

135 REPORT OF THE PUBLIC RELATIONS COMMITTEE Mukund S. Chorghade, Chair

· All activities listed in this report were publicized extensively in The Nucleus · Information relating to all activities was provided to The Nucleus, the Boston Globe, and posted on the NESACS web site; information relating to the Esselen and Norris Awards were publicized in national journals. · Press releases relating to Section activities were written, as information was provided and upon request from officers and committee chairs; these were distributed appropriately via flyers, The Nucleus, area newspapers, Chemical & Engineering News, and area television and radio stations. In addition, information was personally provided to journalist contacts at the Wellesley Townsman, Natick Bulletin and New England India News. · Dr. Chorghade personally delivered flyers, mentioned forthcoming programs and solicited participation from scientists at companies he visited on business engagements. Particular attention was devoted to recent entrants into industry and scientists who had recently relocated to the Boston Metropolitan area. . · Publicity for the programs of the local section was enhanced by targeted e-mailings to the practicing chemists at the biotechnology companies in the area. Companies were encouraged to distribute the notices to their employees and to place them on display on public notice boards. We have secured contacts, via the Mass Biotechnology Council at several biotechnology companies in the area. A personal letter was sent to chemists in these companies soliciting participation in the section's activities. · A photographer was present at all meetings during which awards were presented; i.e., · April Esselen Award · May Education Awards · October Hill Award and 50-year Member Certificates · November Norris Award · A photographer was present at additional activities of the Section, including the Phyllis A. Brauner Memorial Lecture, the German Program, the Medicinal Chemistry programs, and National Chemistry Week activities.

Monthly Meetings: Flyers were e-mailed to individuals, businesses, and colleges approximately three weeks prior to each monthly meeting; approximately 1,800+ monthly meeting flyers were mailed during the year with a similar number of reminders e-mailed one week prior to each meeting.

· Medicinal Chemistry Symposia: A total of 1350+ flyers were e-mailed to publicize the three Symposia conducted by the Medicinal Chemistry Group.

· 50-Year Member Recognition: Invitations to attend the October meeting as guests of the Northeastern Section were sent to 44 members celebrating their 50th year of membership.

· Esselen Award: 200+ flyers were e-mailed publicizing the Esselen Award Program in addition to formal invitations sent to ~150 people.

· Hill Award: Invitations to attend the October meeting as guests of the Northeastern Section were sent to 19 past award winners and two members of the family of Henry A. Hill.

· Norris Award: A total of ~120 formal invitations to the James Flack Norris Dinner and Award Ceremony were mailed to individuals and couples representing approximately 200 people.

136 · Phyllis A. Brauner Memorial Lecture: ~200 flyers were mailed and/or e-mailed to individuals and businesses relating to the Phyllis A. Brauner Memorial Lecture conducted at Wellesley College

· ACS Short Courses: More than 1,000 flyers were mailed publicizing the two ACS Short Courses offered by the Section, as follows:

College and University Programs:

· German Programs: Invitations and flyers were mailed relating to the German Program conducted in the spring; with additional letters and applications mailed to colleges relating to the German Program planned for 2004. · Levins Prize: Publicity was provided via the web site, The Nucleus, and e-mails informing individuals in all of the graduate programs within the geographical area of the Northeastern Section to publicize the process for requesting to be considered for the Levins Prize. · Norris-Richards Summer Research Scholarships: Letters, flyers, and application forms were mailed to 96 college chemistry and/or chemistry-related departments within the geographical area of the Northeastern Section. · Grants-in-Aid: Flyers and applications were mailed to every college chemistry and/or chemistry- related department within the geographical area of the Northeastern Section publicizing the Section's Grant-in-Aid Program to provide financial assistance to undergraduate college students to attend and participate in a National Meeting

High School Programs

· Richards Secondary School Teaching Award: This award was made known to 395 high schools to which flyers and applications were mailed. · Newell Awards: A total of 388 letters were sent to high schools including applications to participate in the competition for the Lyman Newell Award providing financial assistance to attend the NEACT Summer Conference. · Ashdown Examination: Informational letters and applications were mailed to 396 high schools and additional reminder letters sent to all of the individual teachers who had participated in the Ashdown Examination for the past three years. · Connections to Chemistry: Flyers were mailed to 388 high schools publicizing the Connections to Chemistry program that was conducted in conjunction with National Chemistry Week.

137 Flyer Soliciting Public Relations Support

Northeastern Section - American Chemical Society Public Relations Committee

NESAC is looking for a few Good Enthusiastic writers to:

¨ Serve as local section publicist for events and activities ¨ Serve with local section chair as spokesperson for NESACS

Requirements: Good writer Ability to create Good publicity Ability to establish and maintain acquaintanceships with key media people Informed Innovative and imaginative

Outcomes:

¨ Provide public relations expertise at the local level ¨ Increase media coverage ¨ Communicate awareness of local section activities such as (but not limited to) ¨ National Chemistry Week ¨ Project Seed ¨ Chemistry Olympiad ¨ Education Night and other Awards meetings

National ACS has training sessions and will provide editorial and other assistance.

If interested and want to know more about what this will entail, please contact:

Jean Fuller-Stanley Ph.D. NESACS Chair-elect 2003 [email protected] 781 283 3224

138 Example of NCW Press Release: This program was also advertised onRadio Station WCRB during Kids Concert Hour attracting several families who had not previously attended NESACS events.

Jean Fuller-Stanley Professor of Chemistry, Wellesley College & NESACS 2004 Chair

139 REPORT OF THE PUBLIC SERVICE COMMITTEE - EDUCATION TASK FORCE - 2002 James A. Golen, Chair and William L. Dills, Jr.

Science (mostly hands-on classroom) outreach activities

We wish to report the following school activities for the 2003 year. We would also like to note that these activities were significantly reduced during 2003, due to the fact that both of us had job changes that limited our availability for this type of programs.

Activities for 2003

3/19, Middleboro, MA – Elementary School (5th grade, about 300 students) Chemistry Show 3/19, Middleboro, MA – Elementary School (4th grade, about 300 students) Chemistry Show 3/20, Middleboro, MA – Elementary School (3rd grade, about 300 students) Chemistry Show 5/1, Rochester, MA - Elementary School (Brownie Troop 689 Tie Dye 15 2nd and 3rd graders) 5/2, Dartmouth, MA – Cushman elementary School, (70, 5th graders) Tie Dye 6/24 Cotuit, MA – Public Library, Summer Program (50 3rd-5th graders) Tie Dye 7/10, Dartmouth, MA – UMASS Dartmouth (250 high schools students) Chemistry Show 7/12, Dartmouth, MA – UMASS Dartmouth (250 high school students) Chemistry Show 12/4, Dartmouth, MA - Cushman elementary Schools (70, 5th graders) Polymers 12/27 Dartmouth, MA – UMASS Dartmouth (200 individual – general public) Chemistry Show 12/28 Dartmouth, MA – UMASS Dartmouth (200 individuals – general public) Chemistry Show

2003 ANNUAL REPORT of the BOARD OF PUBLICATIONS Marietta Schwartz, Chair

The Board of Publications of the Northeastern Section is responsible for the publication of the section’s publication The Nucleus, as well as the section directory and the section’s web page. The Board consists of three members who serve for a three year term (one member is appointed by the Section chair each year). The members for 2003 were Marietta Schwartz (chair), Patrick Gordon and Vivian Walsh, and Samuel Kounaves as Webmaster. Joseph Billo acted as a consultant to the Board of Publications.

Board meetings were held on a regular monthly basis, except during the summer months. In addition to the three voting members mentioned above, the Editor (Arno Heyn), Associate Editor (Myron Simon) and Advertising Manager (Vince Gale) regularly attended the meetings. The Business Manager (Karen Piper) attended occasionally.

140 Ten issues of the Nucleus were published during 2003: four 20 page issues, three 24-page issues, two 28- page issues and one 32-page issue, for a total of 240 pages. Of this, 66.1 pages (27.5%) were advertising. A directory was not produced this year. The October issue included the second annual Nucleus Buyers Guide. This was a listing of suppliers, products, and services of interest to the Section members.

Advertising revenue was almost $7,000 higher than anticipated, and both production and administrative costs were on budget, with the result that The Nucleus finished the year having used only 75% of the allocated funds from the Section. An abbreviated Financial Report may be found on the following page, and a detailed report is attached.

In an effort to include in The Nucleus more material of general interest, articles such as the following were included (in addition to regular features such as meeting reports, eight book reviews, three Summer Scholar reports, historical notes, safety issues, puzzles):

· ACS Delegation Travels to Cuba (March) · Felice Frankel’s Imagery: Interstellar Chemistry by Klemperer, Faraday Lecture, from the author and also in Proceedings, The Royal Institution (April) · Edward Frankland’s Crusade for Clean Water by Sharon Bertsch McGrayne, from Chem. Heritage (May) · NESACS - YCC - GDCh/JSF Exchange Trip to Germany; ACS Career Services (Summer) · How to Function in Cross-Functional Teams; Friedrich Miescher, the Man Who Discovered DNA by George Wolf, from Chem. Heritage (September) · Communicating Chemistry - From Large Classes to the General Public by David N. Harpp, 2003 Norris Awardee

Frank Gorga, the section’s Webmaster, resigned at the end of 2002. A major item of business for the Board during the end of 2002 and early 2003 was finding a replacement; after a short search, Samuel Kounaves of Tufts University volunteered to take on the task. During the first few months of 2003 he completely redesigned the website, taking it (in the opinion of the Board) to the next level and doing an excellent job of keeping it up to date, including PDF files of each issue of The Nucleus and a very current calendar. A usage summary for the section website is appended. The Board wishes to express its great appreciation for the job that Sam has been doing this past year.

Arno Heyn, the long-time Editor for The Nucleus, gave notice of his intent to resign after the May 2004 issue. An ongoing project for the Board is searching for a permanent replacement for Arno; a task that will not be easy.

Respectfully Submitted,

Marietta H. Schwartz Chair, Board of Publications (2003)

141 Annual Reports for 2002, 2003 (from Arno Heyn)

2003 Total pp. Ads. Pp 2002 Total pp. Ads. Pp. January 20 6.17 24 6.6 February 20 7.83 20 7.7 March 24 7.67 28 7.9 April 24 6.33 20 5.3 May 32 6.33 32 7.7 Summer 24 7.33 48* 16.8 September 28 7.67 20 6.7 October 28 5.42 28 5.2 November 20 5.67 20 4.7 December 20 5.67 20 5.7 TOTALS 240 66.09(27.5%) 260 74.3(29%) % of budgeted pp 96.8% 100% *Special National Meeting Issue

Special Articles in 2003: · ACS Delegation travels to Cuba (March); · Felice Frankel’s Imagery; Interstellar Chemistry by Klemperer, Faraday Lecture, from the author and also in Proceedings, The Royal Institution, London (April) · Edward Frankland’s Crusade for Clean Water by Sharon Bertsch McGrayne, from Chem. Heritage (May) · NESACS – YCC-GDCh/JSF Exchange trip to Germany; ACS Career Services (Summer) · How to Function in Cross-Functional Teams; Friedrich Miescher, The Man who Discovered DNA by George Wolf, from Chem. Heritage (September) · Annual NUCLEUS Buyers Guide (October) · Communicating Chemistry – From Large Classes to the General Public (by Harpp, 2003 Norris Awardee); Harold R. Paretchan – Promoter of the Public Appreciation of Chemists; Ion Chromatography by Hamish Small, from Chem. Heritage (December)

Also: Eight Book Reviews, three Summer Scholar Reports

Respectfully submitted,

Arno Heyn, Editor

142 Web Site Usage Summary (from Samuel Kounaves)

Summary by Month

Daily Avg Monthly Totals Month Hits Files Pages Visits Sites KBytes Visits Pages Files Hits

Jan 2004 882 576 202 119 1343 486676 1912 3233 9229 14127 Dec 2003 813 544 220 114 2201 789214 3555 6833 16886 25220 Nov 2003 962 635 216 108 2568 957330 3261 6489 19050 28882 Oct 2003 1093 749 224 125 2720 1117137 3899 6951 23248 33897 Sep 2003 1023 686 305 122 2196 785584 3668 9167 20596 30699 Aug 2003 723 524 143 68 1877 640693 2129 4443 16254 22422 Jul 2003 765 549 176 84 1913 745013 2630 5481 17032 23737 Jun 2003 769 562 144 83 2132 745477 2504 4337 16865 23073 May 2003 932 670 186 88 2382 874277 2758 5770 20778 28894 Apr 2003 1181 785 216 105 2247 940973 3171 6504 23577 35448 Mar 2003 1216 818 241 101 2284 912824 3132 7493 25384 37704 Feb 2003 1182 842 227 93 961 314247 939 2274 8422 11821

Totals 9309445 33558 68975 217321 315924

143 Board of Publications Financial Report for 2003 (summarized)

budgeted actual Income: Advertising sales $46,000 $53,229

Expenses: Administration (editor, business manager, $10,000 $9,708 office expense) Production (printing, assembly, mailing) $48,490 $48,424 Advertising Commissions $11,500 $13,012 Total expenses $69,990 $71,145

Operating Deficiency (from Section funds) $23,990 $17,916 [This includes Section funds, Norris funds, and Nominating Committee expenses]

Receivables as of December 31, 2003 were approximately $12,930 (comparable to last year).

144 REPORT OF THE RICHARDS MEDAL COMMITTEE - 2003 Patricia A. Mabrouk, Chair

This report summarizes the work of the T. W. Richards Medal Committee for the year 2003.

The Richards Medal is awarded bi-annually to an individual whose work has been recognized for "Conspicuous Achievement in Chemistry." The work of this committee in 2003 related to the selection of an individual to receive the Richards Medal at the Award Ceremony to take place in March, 2004.

The Richards Medal Committee is composed of four members elected by the Northeastern Section, two ACS members who are not members of the Northeastern Section, and the Editor of the Journal of the American Chemical Society. The 2003 committee was composed of the following:

From the Northeastern Section, ACS Prof. Pam Mabrouk, Chair Northeastern University Dr. Charles Kolb President of Aerodyne, Inc. Dr. Mary Mahaney Haartz, Inc. Prof. Vahe Marganian Bridgewater State College From outside of the Northeastern Section: Prof. Josef Michi University of Colorado Prof. Kristin Bowman-James University of Kansas Prof. Peter J. Stang Editor, Journal of the American Chemical Society

Prof. John Ross, Camille and Henry Dreyfus Professor of Chemistry, Emeritus, at Stanford University was identified as the 2004 T. W. Richards awardee. He will be presented with the award at the dinner meeting of the Northeastern Section to be held at Harvard University on March 11, 2004, at which time he will give an address entitled Complex Chemical, Biochemical Reaction Mechanisms: Determination and Synthesis.

from The Nucleus

145 REPORT OF THE SPEAKERS' BUREAU COMMITTEE - 2003 Susan Buta, Chair

The NESACS is reviving the James Flack Norris Speakers Bureau,. The Speakers Bureau committee, chaired by Director-At-Large, Susan Buta, focused on researching the needs and interests of possible users of the Speakers Bureau. Sixty high schools, seven colleges and universities, eleven townships and cities, four community organizations, two Upward Bound programs, one Museum of Science, and one collegiate organizations were contacted with about a 15 per cent response rate. The results and a Call for Section Participants are scheduled for publication in the February 2004 issue of The Nucleus.

REPORT OF THE SUMMERTHING COMMITTEE - 2003 Wallace J. Gleekman, Chair

Summerthing I: April 14, 2003 Boston Red Sox vs. Tampa Bay Devil Rays

The Red Sox did it again. It was another come from behind victory over the Tampa Bay Devil Rays in the bottom of the ninth. Shea Hillenbrand’s bases loaded single - his fourth hit of the game - brought the Red Sox to a 6-5 win. In the final inning, Bill Meuller walked. Nomar Garciaparra singled to center. Manny Ramirez then flied to center with Meuller going to third. Todd Walker walked loading the bases. Hillenbrand singled up the middle and that was the ball game.

In the eighth inning the 5 to 1 lead enjoyed by the Red Sox disappeared as the Devil Rays came up with four runs. Casey Fossum, the starting Red Sox pitcher, had given up a second inning home run to Terry Shumpert and gone seven innings striking out four in a masterful performance. But then the roof fell in. Ramon Mendoza, recently acquired from the Yankees, took over and couldn’t hold the lead. Two singles, a wild pitch and another single produced two runs. Then two more singles tied up the game. Mendoza had faced four batters, given up four singles and four runs with not one out recorded. Manager Grady Little was soundly booed when he came out to remove Mendoza who was likewise showered with boos. Mike Timlin came on to finish the eighth and nonth for his second win.

Johnny Damon doubled and homered in the game as the Red Sox pounded out 15 hits. It was a very cold night at Fenway Park as the fans including NESACS members came all bundled up but many others stayed away from the game. The attendance of 29,617 was not a sellout (33,691) - one of the rare events of the season. During the game the message board in right field spelled out “Red Sox Welcome American Chemical Society”.

Summerthing II: May 15, 2003 Boston Red Sox vs. Texas Rangers

NESACS members were treated to a sterling performance by Pedro Martinez, ace of the Red Sox pitching staff. Pedro allowed five hits in six shutout innings as the Red Sox beat the Texas Rangers 12 to 3. Martinez struck out eight and walked one before leaving with a 10-0 lead. Only one Ranger base runner reached third against him. Alan Benes allowed six runs on seven hits and two walks before leaving with nobody out in the fourth inning.

146 Boston scored two runs in the third when Nomar Garciaparra’s popup fell in front of right fielder Carl Everett and then bounced by him for a triple. In the fourth the Red Sox put together three consecutive singles before Bill Mueller’s triple chased Benes. In the sixth, Johnny Damon tripled, Todd Walker doubled, Garciaparra doubled and David Ortiz signled to give the Red Sox a 10-0 lead. In the seventh, Everett homered for Texas making it 10-2 and giving the Boston fans even more reason to boo him. Everett had had two disruptive seasons with the Red Sox before they traded him to the Rangers. After a half inning of the crowd chanting “Throw it back!” a fan finally threw the ball back onto the field. The sell out crowd of 34,017 erupted in cheers. During the game the message board displayed a sign that said “Red Sox and Fenway Park Welcome Northeastern Section, Amer Chem Soc”

Summerthing III: September 23, 2003 Boston Red Sox vs. Baltimore Orioles

What a game our NESACS members were treated to!! With the Red Sox vying for a wild card slot - the magic number was 4 - the sellout crowd of 33,723 was waiting for a recovery from the disastrous loss to the Cleveland Indians the day before. After Sox starting pitcher Tim Wakefield gave up a three run homerun to Luis Matos, the Orioles lead by a 3 to 2 score going into the final inning. Then, in the top of the ninth, the Orioles scored twice to take a commanding 5 to 2 lead. But none in the crowd left. After the first out, none left. After the second out, none left. And then pinch hitter Jason Varitek hit a single. Nomar Garciaparra drew a walk. Two on and two out. The count went to 3 and 2 on Todd Walker, one strike away from an Orioles victory. But Walker hit a line drive to right field. The right fielder turned the wrong way and then turned back. But it was too late, the ball just barely cleared the fence and dropped into the bullpen for a home run. Tie game!

In the tenth inning, lead off hitter David Ortiz hit a towering fly ball into the new seats atop the “Green Monster” and the game was over. Wave after wave of cheers echoed down from the grandstand. Players rushed out of the dugout to greet and surround Ortiz as the crowd shouted “Orteez, Orteez”.

The magic number is now 3 and, during the game, the message board flashed the sign “Red Sox and Fenway Park Welcome Northeastern Section, Amer Chem Soc” Red Sox from The Nucleus Tickets April 17, 2003 at 6:05 pm Red Sox vs. Tampa Bay Devil Rays May I5, 2003 at 7:05 pm Red Sox vs. Texas Rangers

Right field box seats (normally @ $37) available for $27. Call Marilou Cash- man at 800-872-2054, then send a check to her: 23 Cottage St., Natick, MA 01760.

For information, call: Wally Gleekman at 617-527-1192

147 REPORT OF THE TREASURER - 2003 James U. Piper, Treasurer

James U. Piper Treasurer

REPORT OF THE BOARD OF TRUSTEES - 2003 Esther A. H. Hopkins, Joseph A. Lima, Michael E. Strem

The Trustees of the Section for the year 2003 were Esther A. H. Hopkins, Michael Strem and Joseph Lima. We met with our financial consultant, Robert M. Sarly, Senior Vice President at Smith Barney, Inc., held informal meetings, received reports from Smith Barney and from Piper Enterprises and discussed recommendations for the Board as to uses for the Funds in our care in keeping with the wishes of the donors of the funds.

As voted by the Board of Directors on April 10, $25,000 in Permanent Trust Fund assets in the Consolidated Account was designated for the Brauner Memorial Fund. The date for recalculating the Consolidated Account percentages was set at March 31, 2003. The net value of the Consolidated Account on that date was $1,203,615.55. The Permanent Trust owned 16.5204% of the Consolidated Account on that date so that the transfer resulted in the Brauner Trust owning 2.0771% of Consolidated and the Permanent Trust owning 14.4433%. The Brauner Trust “income account” will hold both additional principal and income until such time as the principal additions have stabilized, at which time all of the principal will be transferred to the Consolidated Account.

As a result, the Trust Funds of the Northeastern Section are now in three Trust Accounts and six income accounts. The Trust Accounts are (one)—the Consolidated, comprising the principal amounts of the Richards, the Norris, the Publication, the Permanent, the Hill and a portion of the Brauner trusts, (two)— the Esselen Trust, and (three)—the Levins Trust. To keep the capital ratios constant in the Consolidated Trust, capital amounts withdrawn from it are distributed to the Income accounts in the ratio of their ownership.

The Consolidated Account for 2003 had an opening portfolio value of $1, 225,333.78. Withdrawals made over the year totaled $48,000. The adjusted opening balance was, therefore, $1,177,333.78. The closing balance was $1,539,184.89 for an increase of $361,851.11. This represents a gain of 31%. The

148 Consolidated Trust contains money funds, common stocks, closed end funds, mutual funds and corporate bonds. The current yield at year-end was 4.51% and the annualized anticipated income was $69,424.45.

The Esselen Fund, comprising money funds, mutual funds and government bonds, had an opening balance of $443,406.06. $12,000 was withdrawn for the expense of the award this year. The adjusted opening value was $331,406.06 and the closing value was $457,990.57. The Levins Fund, comprising money funds, common stocks, and mutual funds had an opening portfolio balance of $10,589.37. No funds were withdrawn during the year. The closing portfolio value was $13,689.87. The Brauner Trust “income account” comprised of money funds, common stock and closed end funds had a closing value of $14,738.89 of which $741.68 was income and the remainder was Trust principal.

The Hill income account comprising only money funds had an opening portfolio value of $9,743.18, received $2,397.16 from the prorated distribution from the Consolidated Account, and wrote checks for $4,000.00 for an adjusted value of $8,140.34. The closing value was $8,208.42. The Norris Award income account, comprising money funds, common stocks, and mutual funds had an opening portfolio value of $17,532.16 and an adjusted value of $10,043.23 after receiving 28,002.91 from the prorated distribution and writing checks for $35,491.84. The closing portfolio value was $12,565.81. The Permanent income account, comprising money funds and common stocks had an opening portfolio value of $48,882.26, received $7,431.29 from the prorated distribution and wrote checks for $13,953.78 for an adjusted value of $42,359.77. The closing value of the portfolio was $50,035.58. The Publication income account, comprising money funds and common stocks had an opening portfolio value of $31,351.94, received $3,918.82 from the prorated distribution and wrote checks for $4,000.00 for an adjusted value of $31,270.76. The closing value was $35,184.14. The Richards income account, comprising money funds, common stocks, and mutual funds had an opening value of $43,938.79, received $5,751.32 from the capital distribution, wrote checks for $16,437.88 for an adjusted value of $33,252.23. The closing value was $42,009.53.

Respectfully submitted,

The Trustees

Esther A.H. Hopkins Michael Strem Joe Lima

149 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5-A

Programs: NSCRC Connections to Chemistry

http://www.nesacs.org

150 Complete Program - NSCRC The Fifth Annual Northeast Student Chemistry Research Conference

Boston University Metcalf Center for Science and Engineering April 26, 2003

151 TABLE OF CONTENTS

Members of the NSCRC 2003 Organizing Committee 2

The American Chemical Society (ACS) 3

The Northeastern Section of the ACS (NESACS) 3

ACS Younger Chemists Committee 4

NESACS Younger Chemists Committee 4

Acknowledgements 5

Schedule of Events 6

Abstracts: Oral Presentations 8

Abstracts: Poster Presentations 11

Author Index 32

Map of the Metcalf Center for Science and Engineering 35

Biography: The Capstone Speaker 7 Professor Charles Lieber of Harvard University

152 MEMBERS OF THE NSCRC 2003 ORGANIZING COMMITTEE

Co-Chairs:

SuzAnn Hertzler, Boston University Lauren Wolf, Boston University

WebMaster:

LinTao Bu, Boston University

Program and Printing:

Truc Diep, Boston University Dawn Troast, Boston University

Gifts and Journal Committee:

Aida Herrera, Tufts University Ivan Korendovych, Tufts University Sonia Taktak, Tufts University

Set-up and Arrangements:

Erin Eastwood, Boston University Christina Fields, Boston University Justyna Kucharczak, Boston University Jennifer Levine, Boston University Karen Miller, Massachusetts Institute of Technology

Steering Committee:

Amy Tapper, GelTex Pharmaceuticals, Inc. Dr. Ruth Tanner, University of Massachusetts Lowell

153 The American Chemical Society

The ACS is a self-governed individual membership organization that consists of more than 163,000 members-60% from industry, at all degree levels. This provides ample opportunity for peer interaction, regardless of your professional or scientific interests.

The ACS seeks to: · Promote the public perception and understanding of chemistry and the chemical sciences through public outreach programs and public awareness campaigns · Assist the federal government with advice on scientific and technological issues involving the chemical sciences · Enrich professionals in academia and private industry through development programs, peer interactions and continuing educational courses · Host national, regional and local section meetings for the exchange of ideas, information and chemical research discoveries · Foster communication and understanding between members, the chemical industry, the government and the community to enhance the quality of scientific research, support economic progress and ensure public health and safety

The Northeastern Section of the American Chemical Society

The chemical society of Philadelphia was the forerunner of what later became the American Chemical Society. Celebrating 150 years the ACS was founded in New York in 1896. Two years later in 1898, the Northeastern Section of the ACS was begun when a group of 150 chemists gathered together in Parker House, thus initiating a series of monthly meetings which have continued to the present day. NESACS enjoyed its centennial anniversary in 1998 and is one of the largest local sections. The current chair of NESACS is John L. Neumeyer, McLean Hospital, Harvard Medical School.

Membership activities have resulted in a number of National Awards, such as the grassroots Award from the ACS office of Legislative and Government and the Outstanding Local YCC Section Award. The NSYCC & the NSCRC are excellent examples of the way in which a professional organization, working in tandem with its younger members, can yield a fruitful outcome, ensuring continuing growth in membership and securing the society's future.

154 American Chemical Society Younger Chemists Committee

The American Chemical Society Younger Chemists Committee was formed to identify needs and concerns of younger chemists and to develop programs responsive to their needs. We are driven by our three strategic goals: 1. To make the ACS relevant to younger chemists 2. Increase the involvement of younger chemists in the ACS at all levels 3. Develop mechanisms to integrate younger chemists into the profession

What are Younger Chemists? One YCC member coined the definition: "Younger chemists are people not yet established in their careers. The criterion for being a member of this group is not age, but experience."

YCC is a Joint Board-Council committee of the ACS whose members represent industry, government and academis. Committee members are appointed for three-year terms by the ACS President and Chairman of the Board. The Committee holds executive and open sessions at each ACS national meeting and any interested chemist is welcome to participate.

The Northeastern Section Younger Chemists Committee The Northeastern Section Younger Chemists Committee (NSYCC) is a local section YCC devoted to the professional advancement of chemists in industry, government laboratories, undergraduate institutions, graduate schools, and postdoctoral positions. Its membership is drawn from the northeast region's colleges and universities, corporations and laboratories. We hope to expand our membership in the NSYCC by including representatives from different northeastern colleges and universities as well as industrial corporations.

155 ACKNOWLEDGEMENTS

The members of the Northeastern Section of the American Chemical Society’s Younger Chemists’ Committee would like to thank the following people and sponsors for their generous contributions:

Amanda Donathen, AAAS Charise Liggins, Nature Adam Kirszner, Wiley ACS NESACS Justin Stewart, American Physical Society Bret Tobias and Ramon Sender, Institute of Physics Maureen Naff, Kluwer James Tonna, Elsevier Diane Saulon, Jessica Cole, and Samantha Crew, Dekker Lesley Maw and Clare Viney, Royal Society of Chemistry Jessica Vakili, CRC Press Linda Morris, Journal of Chemical Education Florence Sumaray, American Chemical Society

Alfa Aesar US EPA/Green Chemistry Program Special Thanks to the Judges of the Oral and Poster Presentations:

Cassandra Celatka, Suntory Pharmaceutical Research Laboratories, Inc. Angeles Dios, GeltexPharmaceuticals Anthony Fernandez, Merrimack College

156 SCHEDULE OF EVENTS

8:30 - 9:00 Poster Set-Up and Registration, Breakfast

9:00 - 9:15 Welcoming Remarks

9:15 - 9:35 Trina L Foster (Boston University) “Modeling Nature's Pathways: Reproducing the Remarkable”

9:35 - 9:55 Meaghan O’Keefe (Boston College) “Engineering DNA-electrode connectivities: manipulation of linker length and structure”

9:55 - 10:15 Ivan V. Korendovych (Tufts University) “Iron complexes with pentadentate macrocyclic ligands as potential enzyme mimics”

10:15 - 10:30 Coffee Break

10:30 - 10:50 Justin Tourigny (Boston University) “Investigating SZ2 Energies of Protonation through Density Functional Theory and the QALE model”

10:50 - 11:10 Andrei Burnin (Dartmouth College) “SCnS linear chain production by direct laser ablation”

11:10 - 11:30 Christopher Crafts (Merrimack College) “Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems”

11:30 - 12:30 First Poster Session

12:30 - 1:00 Lunch

1:00 - 2:00 Second Poster Session

2:00 - 2:30 German-Exchange Program and 2003 Trip Presentation

2:30 - 3:30 Capstone speaker, Dr. Charles Lieber of Harvard University: “Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things”

3:30 – 3:50 Award Presentations: Brauner Undergraduate Book Award (sponsored by the Education Committee of NESACS) Oral and Poster Presentation Awards (sponsored by the ACS)

3:50 - 4:00 Closing Remarks, Poster Take-Down

157 THE CAPSTONE SPEAKER:

Dr. Charles Lieber Department of Chemistry and Chemical Biology, Harvard University

“Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things”

Charles M. Lieber was born in Philadelphia, PA in 1959. He attended Franklin and Marshall College for his undergraduate education and graduated with honors in Chemistry. After doctoral studies at Stanford University and postdoctoral research at the California Institute of Technology, he moved in 1987 to the East Coast to assume an Assistant Professor position at Columbia University. Here Lieber embarked upon a new research program addressing the synthesis and properties of low-dimensional materials. His early work at Columbia was recognized by a number of awards, including Presidential Young Investigator Award, David and Lucile Packard Fellowship in Science and Engineering, and a Sloan Fellowship. Lieber moved to Harvard University in 1991 as a Professor of Chemistry and now holds a joint appointment in the Department of Chemistry and Chemical Biology, where he holds the Mark Hyman Chair of Chemistry, and the Division of Engineering and Applied Sciences. At Harvard, Lieber has pioneered the synthesis of a broad range of nanoscale materials, the characterization of the unique physical properties of these materials, and the development of powerful methods of hierarchical assembly of nanoscale wires, together with the demonstration of visionary applications of these materials in nanoelectronics, biological sensing and nanophotonics. Lieber has also pioneered the creation and application of new chemically sensitive microscopies for probing organic and biological materials at nanometer to molecular scales. This work has been recognized by a number of awards, including the Feynman Award in Nanotechnology, ACS Pure Chemistry Award, NSF Creativity Award, and Leo Hendrik Baekeland Award. Lieber is a Fellow of the American Academy of Arts and Sciences, American Physical Society and the American Association for the Advancement of Science, and serves on the Editorial and Advisory Boards of a number of science and technology journals. Lieber has published more than 200 papers in peer-reviewed journals and is the principle inventor on more than 15 patents. In his spare time, Lieber recently founded a nanotechnology company, NanoSys, Inc., with the modest goal of revolutionizing commercial applications in chemical and biological sensing, computing, photonics, and information storage.

Oral Presentations

1. Modeling Nature's Pathways: Reproducing the Remarkable Trina L Foster, John P Caradonna Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

2+ Model complexes such as [Fe2 (H2Hbamb)2(N-MeIm)2], [1], (H-2Hbamb, 2,3-bis(2-hydroxybenzamido)2,3- dimethylbutane) have been developed in order to investigate the mechanistic pathway of analogous metalloenzymes. In the presence of oxygen atom donor molecules, [1] has shown the ability to catalyze the hydroxylation of alkanes and arenes, the epoxidation of alkenes and the oxidation of sulfides. Recent studies have shown the ability of [1] to heterolytically cleave 2-methyl-1-phenyl-2propyl hydroperoxide (MPPH). Examinations into the oxidative ability of [1] have been carried out using a variety of alkane substrate and sulfides. The results show that [1] is capable of

158 highly efficient oxygen atom transfer chemistry in high turnover numbers. Recent studies have focused on the mechanistic pathways employed by this complex in order to better understand its relevance as a biological model.

2. Engineering DNA-electrode connectivities: manipulation of linker length and structure Meaghan O’Keefe, Bradford J. Taft, and Shana O. Kelley Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

The development of electrical or electrochemical DNA-based biosenors requires the attachment of oligonucleotides to electrode surfaces through linkages with appropriate structural and electronic properties. Using a straightforward and versatile synthetic method, we prepared DNA molecules with a series of aliphatic and aromatic thiol-terminated linkers. The modified oligonucleotides self-assemble on gold electrode surfaces and form densely-packed monolayers. The kinetics and extent of monolayer formation are sensitive to the rigidity of the tether and are also affected by the presence of a single-stranded or double-stranded DNA structure. A redox-active intercalator was used to study charge transport through the series of different DNA films. The heterogeneous electron-transfer kinetics are modulated by the structure of the DNA-electrode connection, with a linker attached directly to a DNA base facilitating the most efficient charge transport through the film. These studies constitute the first systematic analysis of the effect of linker structure on DNA-electrode coupling, and provide important information for the development of new electrical DNA biosensors.

3. Iron complexes with pentadentate macrocyclic ligands as potential enzyme mimics Ivan V. Korendovych, Elena V. Rybak-Akimova, William M. Reiff, Richard J. Staples Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

Emulating processes in natural enzymes can lead to development of relatively simple, environmentally friendly complexes capable of selective stereospecific oxidation of commercially available substrates. Macrocyclic ligands containing amide groups were chosen as potential enzyme mimics due to their stable structure, possibility of pendant arm modification and high thermodynamic and kinetic stability, which prevents uncontrolled metal oxidation and hydrolysis. Complexes of Fe(II) and Fe(III) with pentadentate macrocyclic amide containing ligand (1) have been characterized structurally and spectroscopically. The nature of the counter-ions has a significant impact on the coordination mode of the amide group. Mossbauer and magnetic susceptibility studies provided additional information about properties of the complexes. Due to three-dimensional network of hydrogen bonds Fe(III) complex of (1) shows magnetic ordering at 3.2 K. The reaction of Fe(II) complex of (1) with dioxygen has been kinetically studied in different solvents at various temperatures (from -80 ºC to +25 ºC). Formation of an intermediate was observed by UV-Vis spectroscopy.

159 4. Investigating SZ2 Energies of Protonation through Density Functional Theory and the QALE model W. Giering, A. Prock, J. Tourigny Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

The empirical multi-parameter linear regression model called QALE [Quantitative Analysis of Ligand Effects] has been used to correlate physicochemical properties with the stereoelectronic properties of molecules. Using a Density Functional Theory computation with the B3LYP functional, we calculated the Energies of Protonation of a variety of sulfur compounds (SZ2) and compared them to experimental Proton Affinity values using the QALE model. Good approximations and strong correlations to the QALE parameters were found.

5. SCnS linear chain production by direct laser ablation Andrei Burnin and Joseph J. BelBruno Dartmouth College, Department of Chemistry, 6128 Burke Laboratory, Hanover, NH 03755

Cumulenic polycarbons SCnS (n = 2-27) were generated by laser ablation of various mixtures of elemental carbon and sulfur. The resulting molecules were analyzed in a time-of-flight mass spectrometer. The spectra exhibited ideal odd/even intensity alternation attributed to their relative stability and the formation mechanism of the clusters. The structures and energies of the neutral and charged carbon chains capped with two sulfur atoms were studied by density functional theory. The results were consistent with the experimental observations. Evidence of sulfur poisoning of fullerene formation was observed and explained in terms of one of the existing models for fullerene formation and growth.

6. Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems Christopher Crafts and Stephen M. Theberge Merrimack College, Department of Chemistry, 315 Turnpike Street, North Andover, MA 01845

Gold/mercury amalgam microelectrodes were constructed and deployed for in situ volumetric analysis of porewaters in fresh and saltwater sediments. The study sites included ponds, ephemeral pools, and a salt marsh. Voltammetric scans were performed using a portable AIS DLK-60 Electrochemical Analyzer, powered with a standard 12V marine battery. Sediment cores were taken and analyzed in the laboratory when additional analyses were preformed. Voltammetric analysis eliminates the need for cutting and squeezing sediment cores, thus reducing artifacts of the analytical method. The concentrations of several dissolved electroactive inorganic species were determined simultaneously as proxies for the decomposition of organic matter. Profiles of dioxygen, iron(II), manganese(II), and several reduced sulfur species will be shown.

160 POSTER PRESENTATIONS

1. The Chemistry and Biology of the Cytostatic Natural Product Migrastatin Bing Xia, Melissa M. C. Dominguez, Scott E. Schaus Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

The novel macrolide natural product migrastatin displays a remarkable inhibitory effect on the migration of human tumor cells and it also selectively inhibits growth under anchorage-independent conditions, which is characteristic of malignant tumors. Migrastatin is unique because it does not inhibit the synthesis of macrobiomolecules such as DNA, RNA and protein and it is not cytotoxic. Furthermore, migrastatin is shown to be a chemosensitizer of vinblastine in human tumor cells. Migrastatin belongs to a class of natural products which includes isomigrastatin, dorrigocin A and dorrigocin B. Based on their potent anticancer properties, migrastatin and other novel members are ideal synthetic targets. Total synthesis of members of this family would constitute a meaningful contribution to the area of natural product synthesis. More importantly, use of migrastatin and other members to investigate tumor cell migration will result in a significant advance in cellular biology since currently the mechanism is not well understood. The potential use of migrastatin as a treatment for metastasis, the predominant cause of death in most cancer patients, is also very promising since tumor cell migration is required for metastasis. The successful synthesis of migrastatin would supply adequate amounts of materials to investigate its bioactivities and guide the total synthesis of its other family members. Identification of the target protein of migrastatin allows for further investigation into the mechanism of tumor cell migration. Migrastatin will also be chemically modified to obtain structural analogues and the resulting biological mode of action of migrastatin could be used as a model for a therapeutic approach to the treatment of tumor metastasis.

2. Kinetics of 2-carbon hydrogen exchange of 1-Ethyl-3-methylimidazolium bromide Adam W. Turner, Edward J. Dix, and Brian K. Niece Assumption College, 500 Salisbury St. Worcester, MA 01609

The exchange of the 2-carbon hydrogen of 1-ethyl-3-methylimidazolium bromide with water has been observed using NMR and D2O. The rate law for the exchange was determined via the peak height of the 2-carbon hydrogen. As the peak height goes down it follows the first order rate law. We used the rate law observed to calculate the rate constant K. The reaction rate changes as varied concentrations of H+ and OH- are introduced into the reaction. The exchange of a proton with H2O is slowed down in the presence of H+ while in the presence of OH- the reaction is accelerated. We believe the reason for this observation is that OH- is a catalyst in the reaction, which speeds up the process due to the interaction of the hydroxide with the 2-carbon hydrogen of 1-ethyl-3-methylimidazolium bromide. The H+ slows down the reaction because it reduces the amount of OH- present in solution.

3. Controlling surface chemistry via selective excitation of rovibrational states Dan Killelea, R. R. Smith, D. F. Del Sesto, and A. L. Utz Tufts University, 62 Talbot Ave., Medford, MA 02155

The selective rovibrational excitation of molecules in a supersonic molecular beam via direct infrared excitation prepares an ensemble of reactive molecules with well-defined internal and translational energies. We study the dissociative chemisorption probability of these state-selected molecules on clean, single crystal metal surfaces as a function of their translational energy and rovibrational quantum state. Control of rotational, vibrational and translational energy allows insight into the reaction channels available to the molecule in a gas-surface interaction. The selectivity afforded by laser excitation offers an opportunity to control the outcome of a chemical reaction at the gas surface interface. We will report recent results from a series of state-resolved measurements that explore our ability to control the outcome of the reactions.

161 4. The Development of an Efficient Synthetic Methodology to Synthesize a Class of Angiogenesis Inhibitors John Westbrook and Scott E. Schaus Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

A class of compounds called Lignans, have been isolated from various fauna sources and shown strong biological activity as angiogenesis inhibitors and possible anti-rheumatic agents. Angiogenesis is a strictly controlled event in the body, but the exact cellular signaling pathway that these molecules regulate is unknown. Inflammation associated with rheumatoid arthritis and the method through which solid tumors acquire nutrients are two examples of angiogenic associated disorders. The synthesis of these compounds and possible derivatives can provide information such that we gain insight into the cellular signaling pathway. Numerous compounds of biological importance have cyclobutane rings as their core structure. The synthesis cyclobutane rings has been accomplished through a variety of means including photolysis, thermolysis, ring contraction, and radical cyclizations. One of the most direct methods is the dimerization of a carbon-carbon double bond. Catalytic amounts of iron (III) perchlorate has been shown to mediate the stereoselective, radical dimerization of trans-anethole to form cyclobutane rings with a trans-anti-trans relationship. The successful synthesis of the natural product, magnosalin, has been accomplished through the iron (III) perchlorate initiated cycloaddition. The scope of reactivity is currently under investigation.

5. The Synthesis of a Library of Compounds to Understand Cellular Signaling Joshua R. Giguere, Lauren M. Smyla, and Scott E. Schaus Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

The foundation of chemical genetics relies on the ability of a small molecule to alter the function of a particular protein target of interest. Individual small molecules have the ability to bind to a protein, or induce a desired cellular or organismal response, aiding in understanding biological pathways. The first step in utilizing chemical genetics to study protein function is the logical synthesis of libraries of diverse compounds capable of altering cellular function. Stereochemical and structural diversity within the library is important to increase the potential for finding a compound capable of perturbing biological systems. The synthesis of a structurally diverse library of compounds aimed to inhibit the protein kinase casein kinase-2 (CK2) is presented. This library of compounds is based upon the benzopyran scaffold, a common structural unit found in several biologically active compounds, which have been isolated from various plant sources found in Nature. Diversification of the scaffolds will be completed using known methods for Stille coupling, oxime and carbamate formation. Non-natural alkoxyamines will be prepared and used as building blocks within the library, to further enhance structural diversity. The library will be used to help elucidate the unknown cellular signaling pathway(s) associated with CK2.

6. Crystal Structure of the DNA-wrapping Domain of DNA Gyrase A John Huetsch, Alex Ruthenburg, and Greg Verdine Harvard University, 227 Quincy Mail CenterCambridge, MA 02138

DNA gyrase is unique among topoisomerases in that it is able to introduce negative supercoils into DNA using the free energy of ATP hydrolysis. Gyrase’s supercoiling activity is dependent upon the right-handed wrapping of DNA around the gyrase A (GyrA) C-terminal domain. We have determined the 2.6 Å crystal structure of this C-terminal DNA-wrapping domain of GyrA, and have found that it folds as a six-bladed beta-propeller. The structure of the GyrA beta-propeller differs significantly from that of other beta-propellers, in that it does not fold as a flat torus, but instead adopts a right-handed helical rise. We believe that this fold represents a novel class of beta-propeller, which we have termed the beta-screw. The outer perimeter of the GyrA beta-propeller presents a substantial positively charged surface, which we propose serves as the domain’s DNA-wrapping surface. The right-handed wrapping of DNA around the GyrA beta-propeller domain suggests a model of positive node formation between the G- and T- segments that may explain the strict directionality of the gyrase strand passage mechanism.

162 7. Modeling Nature's Pathways: Reproducing the Remarkable Trina L Foster, John P Caradonna Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Monooxygenase enzymes are found throughout the plant, animal and microorganism kingdoms and are responsible for a wide variety of organic transformations. Utilizing a variety of specialized strategies, these mono- and binuclear iron centers activate molecular oxygen and induce heterolytic cleavage of O-O bond thereby generating high-valent iron-based oxidants that are capable of formally inserting and oxygen atom into unactivated C-H bonds. Understanding these biological processes is therefore an area of intense fundamental and commercial interest. 2+ Model complexes such as [Fe2 (H2Hbamb)2(N-MeIm)2], [1], (H-2Hbamb, 2,3-bis(2-hydroxybenzamido)2,3- dimethylbutane) have been developed in order to investigate the mechanistic pathway of analogous metalloenzymes. In the presence of oxygen atom donor molecules, [1] has shown the ability to catalyze the hydroxylation of alkanes and arenes, the epoxidation of alkenes and the oxidation of sulfides. Recent studies have shown the ability of [1] to heterolytically cleave 2-methyl-1-phenyl-2propyl hydroperoxide (MPPH). Examinations into the oxidative ability of [1] have been carried out using a variety of alkane substrate and sulfides. The results show that [1] is capable of highly efficient oxygen atom transfer chemistry in high turnover numbers. Recent studies have focused on the mechanistic pathways employed by this complex in order to better understand its relevance as a biological model.

8. Synthesis of Louisianin C John Beierle, Costa Metallinos, Ekundayo Osumboni, Yajun Zhao, and T. Ross Kelly Boston College, Department of Chemistry, Chestnut Hill, MA 02467

The synthesis of louisianin C, a member of a small family of 3,4,5-trisubstituted pyridyl natural products, is achieved in six steps and 11% overall yield starting from commercially available 3,5-dibromopyridine. The key step is a fluoride-induced desilylation-cyclization to carbinol.

9. Investigating Steady-State and Pre-Equilibrium: A Computation Kinetics Exercise for Undergraduate Physical Chemistry Marianne Mearn and John Beauregard Department of Natural Sciences, Assumption College, Worcester, MA 01609

In this poster, preliminary results of an independent study on Computational Chemical Kinetics will be presented. The goal of this project is the development of an exercise for use in undergraduate Physical Chemistry. The computer program ‘Mathematica’ was used to numerically solve the kinetics equations for the model two-step mechanism: A <---> B ---> C. In particular, the values of the rate constants for the forward and reverse steps in the mechanism were varied systematically. The steady–state approximation and pre-equilibrium are commonly used—perhaps too liberally—by those studying chemical kinetics. It is hoped that this exercise will help students gain a better understanding of the general conditions under which either the steady-state approximation or pre-equilibrium apply.

163 10. Synthesis of the first myo-inositol-1,2-diamine derived ligand for the investigation of iron complexes reactivity. Marc d'Alarcao, Elena Rybak-Akimova, and Viatcheslav N. Azev Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

A method for the preparation of 1,2-didesoxy-1,2-diamino-3,4,5,6-tetrabenzyl-myo-inositol (2) from readily available myo-inositol (1) has been developed. This compound has been converted into 1,2-didesoxy-1,2-di(N- methyl-N-(2-picolyl)amino)-3,4,5,6-tetrabenzyl-myo-inositol (3), which is an analog of the ligands previously employed in preparation of potent catalysts of alkene epoxidation reaction.

11. Spherical Harmonic Analysis of Orientation Dependent Statistical Potentials Derived from Protein Structural Databases Warren Ansaldo, Warren P. Giering, and Alfred Prock Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Using computational methods, gas phase energies of protonation of phosphorus(III) compounds have been calculated and the results analyzed via the QALE model (quantitative analysis of ligand effects). The QALE model employs initial graphical analyses followed by linear regression analysis using four stereoelectronic parameters. The goal is to clarify the quantum mechanical basis of these parameters. The energies of protonation have been calculated at the 6-31**G++ level using GAUSSIAN98 with geometry optimization. The calculated energies are close to experimental proton affinities. These computed results correlate well with the QALE parameters (r2=0.989). The relationship between the quantum mechanical properties of the phosphorus(III) compounds the QALE parameters will be discussed.

12. Intramolecular Inverse Electron Demand Diels-Alder Reaction of Imidazoles with 1,2,4- Triazines: A New Route to 1,5-Naphthyridines and Related Heterocyclic Scaffolds. Grace H. C. Woo, Zhao-Kui Wan, Brian Lahue, and John K. Snyder Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Several years ago, an improved and efficient method to synthesize various 1,2,3,4-tetrahydro-1,5-naphthyridines, related A-ring homologues and similar structural derivatives was reported by our group member. The core structure of the naphthyridines was constructed by an intramolecular inverse electron demand Diels-Alder (IEDDA) cycloaddition of imidazoles tethered to the C3 position of 1,2,4-triazines by tri-methylene linkage in good to excellent yields. In presence of the antioxidant BHT under an argon atmosphere, only nonaromatized 1,2,3,4- tetrahydro-1,5-naphthyridines were observed after the loss of dinitrogen and the immediate elimination of nitrile. The efficiency and the ease of IEDDA methodology to prepare these naphthyridines led to the consideration of these structures as scaffolds to develop a diverse chemical library. Recent investigations involve preparation of these naphthyridines and development of a chemical library from a minimum of three key functional loci for attachment to a support or for further diversifications: the aromatic ester, the secondary amine, and the primary alcohol. These naphthyridine cores are exemplary as scaffolds because they are small, contain two nitrogens and carry functionality suitable for further diversification. Furthermore, 1,5-naphthyridines resemble drug-like structure that has been shown to have wide range of biological activities which make them even more attractive as scaffold.

164 Several model studies were executed to collect preliminary results and confirm the suitability of these 1,2,3,4- tetrahydro-1-5-naphthyridines as library cores. For example, a boronic Petasis Mannich reaction with formaldehyde and secondary amine on the A-ring was preformed on a model naphthyridine to afford N-allyl naphthyridine in good yield (71%, unoptimized). Furthermore, the explosive field of palladium-catalyzed cross coupling reactions has been included in this project. The model naphthyridine was arylated by bromobenzene under various palladium- catalyzed conditions. Hartwig conditions, Pd2(dba)3-DPPF-NaOtBu, gave a very promising yield for this model system, 89%. Preliminary studies were also undertaken to determine the suitability of pyridine carboxaldehydes for further chemistry. A hetero Diels-Alder cycloaddition was performed using 2-pyridine-carboxaldehyde as a model. 2-Pyridinecarboxaldehyde readily reacted with Danishefsky’s diene in presence of Eu(fod)3 to afford cycloadduct and subsequent desilylation gave desired products in good yield (68%, unoptimized). This result indicates that an aldehyde group at C-6 of the tetrahydronaphthyridines should also be successful in similar hetero Diels-Alder reactions. In conclusion, 1,2,3,4-tetrahydro-1,5-naphthyridines are attractive structures to diversify in to a chemical library. The core structures can be readily synthesized by intramolecular IEDDA in good yield based on the preliminary results. Several model studies showed that diversifications at three functional loci on the 1,2,3,4-tetrahydro-1,5- naphthyridine can be easily accomplished.

13. Manipulation of Macrocyclic Complexes with Pendant Amino Arms: Metal Substitution and Arm Modification Aida M. Herrera, Sergey V. Kryatov, Richard J. Staples, and Elana Rybak-Akimova Tufts University, 62 Talbot Ave., Medford, MA 02155

A series of macrocyclic Ni(II) complexes were prepared by the template condensation of a 2,6-disubstituted pyridine (2,6-diacetyl- or 2,6-diformylpyridine) and tris-(3-aminopropyl)amine, followed by the reduction of the azomethine bonds with sodium borohydride. Metal substitution from Ni(II) to Cu(II) was subsequently conducted. All of the metal complexes were structurally characterized by X-ray diffraction. In all of the complexes the protonation of the pendant 3-aminopropyl arm leads to the un-coordination of the arm. The pKa of all complexes was studied by spectrophotometric pH-titrations. Treatment of a reduced nickel(II) complex with acylating agents leads to the modification of the pendant arm. Free macrocyclic ligands with the acylated arms were isolated and characterized by GC-MS and NMR. The Cu(II) complex of a macrocycle with a modified arm was prepared and characterized by X-ray diffraction.

14. Engineering DNA-electrode connectivities: manipulation of linker length and structure Meaghan O’Keefe, Bradford J. Taft, and Shana O. Kelley Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

165 15. Studies Toward the Synthesis of the Novel Antibiotic, CJ-15,801 Chong Han, Ruichao Shen, and John A. Porco, Jr. Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Recently, a novel antibiotic CJ-15,801 which contains the unique N-acyl vinylogous carbamic acid moiety was isolated from the fermentation broth of the fungus Seinatosporium sp. CL28611. This natural product exhibits antibacterial activity against Gram-positive multi-drug resistant (MDR) bacteria and therefore is a potential drug for methicillin-resistant Staphylococcus aureus (MRSA). We have developed a stereoselective, Cu (I)-mediated amidation reaction to prepare N-acyl vinylogous carbamic esters. In this poster, we will report the synthesis of the natural product CJ-15,801 using this methodology and progress towards the synthesis of related N-acyl vinylogous ureas.

16. A Chemical Genomic Approach to Studying the Anti-proliferative Agent Borrelidin Erin L. Eastwood and Scott E. Schaus Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Borrelidin is a natural product that inhibits cell proliferation in a rat aorta matrix which growth has been induced by VEGF. We are interested in studying the molecular mechanism through which borrelidin affects cellular proliferation. Our initial studies included a combination of small-molecule perturbation experiments with traditional genetics, using Saccharomyces cerevisiae as our model system. Whole genome transcription profiling with the drug showed increased transcript levels of the amino acid biosynthetic enzymes. The transcription factor GCN4p is involved in the transcriptional regulation of amino acid biosynthetic genes under cellular stress. We have determined that induction of the amino acid biosynthetic pathway involves GCN4 by treating a yeast strain lacking this gene and observing the absence of increased transcription of these genes. Experiments were repeated using a strain lacking GCN2. The kinase activity of GCN2p results in increased translation of Gcn4p. Treatment of the GCN2 deletion strain showed increased transcript levels of the amino acid biosynthetic enzymes upon treatment with borrelidin. These results indicate that borrelidin induces the transcription of amino acid biosynthetic enzymes through a GCN4 dependent pathway, in the presence or absence of GCN2. These results provide evidence of the primary cellular effects of borrelidin in the model system.

17. Kinetic study of urea binding to dinuclear iron model complexes Sonia Taktak, Sergey V. Kryatov, Elena V. Rybak-Akimova Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

A novel dinuclear iron(III) complex of BPMEN (BPMEN = N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)-ethane-1,2- diamine) with a bridging urea anion has been synthesized and fully characterized by IR, UV-Vis, Elemental Analysis , X-ray diffraction and NMR. The study of its kinetics of formation from the reaction of urea and the 3+ [Fe2(m-O)(m-OH) (BPMEN)2] precursor in acetonitrile is reported. Two steps have been observed which correspond to the addition of urea followed by the elimination of a molecule of water and binding of the deprotonated urea nitrogen. The first step of the reaction is rapid and was studied by stopped-flow techniques. The second step is rather slow at room temperature and was followed using a regular UV- Vis spectrophotometer. The mechanism of urea binding using diiron BPMEN complexes is similar to the one previously described for TPA (TPA = tris(2-pyridylmethyl)amine) analogues1. The slower reaction rates observed with BPMEN species allowed a better detection of the intermediate. Both mechanisms will be discussed and compared.

3+ 3+ 3+ O O O First step Second step (BPMEN)Fe Fe(BPMEN) (BPMEN)Fe Fe(BPMEN) (BPMEN)Fe Fe(BPMEN) + CO(NH2)2 OH O HN O + H2O O H C NH2 H2N NH2 (1) Kryatov, S. V.; Nazarenko, A. Y.; Robinson, P. D.; Rybak-Akimova, E. V. Chemical Communications 2000, 921-922.

166 18. Water Thin Films on Magnesium Oxide Powder Kurt van Vloten University of Massachusetts Boston, Department of Chemistry, 100 Morrissey Blvd., Boston, MA 02125

Metal oxides are commonly used as catalysts and catalytic supports, and water is often present in the reactant feed stream or as a product of reaction. Adsorbed water, in either its molecular or dissociated form, is thought to play a critical role in the mechanism of many metal oxide – catalyzed reactions. Using varying concentrations of potassium hydroxide solutions, we were able to establish dynamic equilibrium between the MgO powder and an environment with a constant relative humidity. Using TGA we were able to monitor water uptake and desorption from the surface of MgO powder under these known conditions. We have found that water both chemisorbs and reversibly physisorbs onto MgO surfaces forming liquid like thin films under ambient conditions.

19. A Cross Metathesis Approach to Isoprostanes Marc L. Snapper and Bhaumik A. Pandya Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

A concise, efficient, and stereoselective total synthesis of the isoprostanes is necessary in order to probe the role of these lipid metabolites generated from free radical oxidation of membrane bound arachadonic in various cell signaling events associated with inflammation and immune response. A synthetic strategy for all of the 5-F2 isoprostanes based on a late stage cross metathesis of two advanced intermediates is being implemented to provide entry to sufficient quantities of these compounds.

20. Structure and Function of Class VII Myosins as Determined by X-Ray Crystallography Samantha Desmarais and F. Jon Kull Dartmouth College, Department of Chemistry, 6128 Burke Laboratory, Hanover, NH 03755

Usher syndrome is an inherited autosomal recessive disorder and is the most frequent cause of deaf-blindness in humans. Patients suffering from Usher syndrome type 1B (USH1B) are born deaf, experience constant inner ear problems, and become progressively blind in the teen years due to retinal degradation. USH1B is caused by mutations in the gene encoding myosin VIIA. Myosin VIIA is a protein with a tail region that contains two MYTH4 domains, two FERM domains, and one SH3 domain. The function of these domains is unknown. Over 55 distinct mutations, located in each of the domains of the myosin VIIA gene, have been identified in patients suffering from USH1B. Recent studies indicate this protein is involved in assembling and maintaining stereocilium, a structure in inner ear hair cells. In order to characterize the structural and functional basis of the mutations identified for USH1B, MyoI, a class VII myosin from Dictyostelium discoideum that has very high homology to human myosin VIIA, will be used. Determination of the MyoI structure and comparison of its wild type and mutant structures will clarify the exact function of myosin VIIA. Rational drug design can then be based on this structure.

Force generation in myosin: Myosin’s prepowerstroke state, based on structures of myosin and actin, determined by X-ray crystallography and modeled into low resolution electron microscopic reconstructions. The lever arm is in the UP conformation. Myosin shown167 on left in red, green, 21. Sequence-Dependent DNA Surface Interactions: Specific vs. Non-Specific Contributions Lauren K. Wolf, Yang Gao, and Rosina M. Georgiadis Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

It has been shown that DNA probe surface density can strongly affect probe-target interactions. As a result, the method of DNA film preparation is very important. The probe immobilization process encompasses both non- specific DNA-surface interactions and specific linker-surface interactions. Here, we examine how DNA sequence composition may affect probe immobilization and consequent probe-target interactions. We use surface plasmon resonance (SPR) spectroscopy to study both thiolated and non-thiolated (non-specific) oligomer attachment to a gold surface. We compare the immobilization kinetics for single-stranded poly(dT) and poly(dA) sequences to random (~50% GC content) oligomers. We also discuss the contributions of non-specific interactions to the overall immobilization process and their effect on subsequent probe-target interactions.

22. Iron complexes with pentadentate macrocyclic ligands as potential enzyme mimics Ivan V. Korendovych, Elena V. Rybak-Akimova, William M. Reiff, Richard J. Staples Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

23. Studies on the Scope and Mechanism of Tricyclo Heptane Thermal Fragmentations Michael J. Williams, Holly L. Deak, and Marc L. Snapper Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

Our current approach toward complex bicyclo decanes involves an intermolecular cyclopropanation of functionalized cyclobutenes followed by a thermal ring expansion. In our efforts to expand the scope and further understand the mechanism of thermal fragmentation, we employed the use of a tethered a-diazocarbonyl to obtain a new cis-syn-cis cyclopropane geometry. With this rigidly confined architecture, we were able to obtain the alternate stereochemical series of cycloheptadiene products upon thermolysis and were therefore able to demonstrate that an alternative mechanism is in effect. We were also able to demonstrate that the cis-syn-cis cyclopropane geometry converts to cis-anti-cis upon tether cleavage indicating that this geometry is thermodynamically more stable.

24. Pi-Cation Interactions in Coiled Coil Model Proteins Brooke Nussbaum and Krishna Kumar Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

The design, synthesis, and characterization of model proteins based on the 33 residue coiled coil domain of the yeast transcription factor GCN4 to study the contribution of the pi-cation interaction to protein stability. The e and g positions of the characteristic heptad repeat were replaced with an aromatic (homophenylalanine) and positively charged residue (lysine)in order to measure the effect of the pi-cation interaction The peptides were synthesized by manual solid phase peptide synthesis using the in situ neutralization protocl with t-Boc chemistry, and purified by

168 reverse phase HPLC. Further characterization of the model peptides using circular dichroism studies and analytical centrifugation are needed to quantitatively determine the magnitude of pi-cation contributions in the context of protein-protein interactions.

25. Asymmetric Catalytic Reductive Coupling of Alkynes and Aldehydes Karen M. Miller and Timothy F. Jamison Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Ave., 18-543 Cambridge, MA 02139

Chiral allylic alcohols are useful building blocks in the preparation of a variety of organic molecules and are found in many natural products with potential therapeutic applications. Existing methods for the generation of enantiomerically enriched allylic alcohols from alkynes and aldehydes require stoichiometric use of a transition metal; the development of a complementary process that is catalytic in transition metal is desirable for both environmental and economic reasons. We have found that a catalyst derived from bis(1,5-cyclooctadiene)nickel(0) and (S)-neomenthyldiphenylphosphine (NMDPP), which are both commercially available, can reductively couple both aliphatic and aromatic aldehydes with a variety of aromatic alkynes to provide trisubstituted allylic alcohols in high yields and up to 96% ee. Exclusive cis addition across the alkyne is observed, and regioselectivities with respect to the alkyne are excellent in all cases. Critical to the reaction development was the observation that the use of a 1:1 mixture of ethyl acetate: 1,3-dimethylimidazolidinone (DMI) as solvent led to significant enhancements in both reactivity and enantioselectivity. The product allylic alcohols can also be transformed into synthetically useful á-hydroxy ketones via ozonolysis. Current efforts are focused on the creation of a more reactive, versatile catalyst system and a broader investigation of substrate scope.

26. SCnS linear chain production by direct laser ablation Andrei Burnin and Joseph J. BelBruno Dartmouth College, Department of Chemistry, 6128 Burke Laboratory, Hanover, NH 03755

27. Investigation of Sequence Variation and Posttranslational Modification of Light Chains Isolated From Patients Diagnosed With Light Chain-Associated Diseases Andrew B. Dykstra, Amareth Lim, Lawreen H. Connors, Mary T. Walsh, Martha Skinner, and Catherine E. Costello Boston University, School of Medicine, Boston, MA 02215

Overexpression of immunoglobulin (IG) light chain (LC) is associated with various diseases, including multiple myeloma (MM) and primary amyloidosis. Sequence variation and posttranslational modification (PTM) may affect

169 the stability of the LC, resulting in misfolding of the protein. To identify proteins obtained from pateints’ urine and to better understand the mechanism of how LC amyloids form, we are using electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) together with enzymatic digestions to verify cDNA-deduced amino acid sequences and investigate sequence variation and PTM of proteins. ESI mass analysis of a purified sample from the urine of one patient indicated it had a molecular mass of 23,514 Da, 119 Da higher in mass than that calculated from cDNA-deduced sequence. MALDI mass analysis of the enzymatic digests gave complete sequence coverage and identified the +119 Da shift as a cysteinylation of Cys214. This protein was confirmed as kappa 1 LC. MALDI mass analysis of another protein isolated from the urine of another patient showed a broad peak at 35,402 Da, suggesting heterogeneity. After treatment with PNGase-F, the broad peak disappeared, indicating N-linked glycosylation. MALDI mass analysis of the Glu-C digestion identified the protein as alpha 1-acid glycoprotein.

28. Trajectory Study of Energy Transfer in Collisional Quenching of Highly Vibrationally Excited Molecules Ziman Li and Amy S. Mullin Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Highly vibrationally excited molecules are strongly involved in a variety of molecular processes. Especially, they play an elementary role in unimolecular and recombination reactions, where collision induced activation and deactivation are essential for a complete dynamic description. So far, both the experimental and theoretical work has revealed many features of collisional energy transfer (CET), however, a satisfactory understanding of the fundamental processes is still largely needed. Most of experimental studies on CET for large polyatomic molecules have dealt with the investigation of aromatic system like azulene, benzene, toluene and C6F6. In our group, we previously studied the energy transfer from highly vibrationally excited azabenzene to H2O, CO2 and DCl bath molecules by using transient infrared absorption spectroscopy. On the theoretical side, trajectory simulations have proved to be a powerful complementary tool gaining information on fundamental mechanism of CET. I studied the CET between highly vibrationally excited pyrazine and CO2. Trajectory study of CET for pyrazine/CO2 is performed aimed at understanding the molecular features that make molecules efficient energy donors or acceptors. The goal is to know what motions of the donor molecule are responsible for the strong collisions; what the dynamics of weak collisions are; if there is any particular orientation or initial condition that preferentially results in supercollisions, and if the classical trajectory calculation can reproduce our experimental results or there are other quantum effects. In classical trajectory calculations, Newton’s Laws of Motion is used for the molecular motion, isolated molecules are treated as collections of harmonic oscillators, and intermolecular potentials are formed by pair-pair Lennard-Jones potentials.

29. Vibrational Energy Relaxation in Myoglobin Lintao Bu and John E. Straub Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

In a previous molecular dynamics simulation study, the kinetic energy relaxation of photolyzed heme in solvated carbonmonoxy myoglobin was found to be a single exponential decay process with the relaxation time constant 5.9 ps [D.E. Sagnella and J.E. Straub, J. Phys. Chem. B 105, 7057 (2001)]. The strong electrostatic interaction of the isopropionate side chains and the solvating water molecules was shown to be the single most important “doorway” for dissipation of excess kinetic energy in the heme. In this work, the results of a molecular dynamics simulation study of heme “cooling” in two modified myoglobins, in which (1) the two isopropionate side chains in the heme are replaced by hydrogen or (2) the proximal histidine is replaced by glycine, His93Gly, are presented. For each “tailored” protein, the relaxation of the heme's excess kinetic energy is found to be a single exponential decay process. For the His93Gly mutant protein, the relaxation time is found to be 5.9 ps in agreement with the relaxation time in native wild type myoglobin. For myoglobin with the modified heme lacking isopropionate side chains, the relaxation time was found to be 8.8 ps - a decrease by 50 % compared to that for native myoglobin. These results lend strong support to the proposal that the predominant channel for fast kinetic energy relaxation of the heme in native myoglobin is directed energy “funneling” through the heme side chains to the surrounding solvent.

170 30. The Asymmetric Morita-Baylis-Hillman Reaction and the Development of Chiral Bronsted Acids for Organo-Catalysis Nolan T. McDougal and Scott E. Schaus Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Asymmetric catalysis provides access to valuable chiral building blocks for synthesis of organic compounds. Traditionally, catalytic asymmetric reactions have been done either through the use of an enzyme or a chiral transition metal species. Few examples exist, however, of asymmetric catalysis by non-enzymatic, organic compounds. Furthermore, little success has been achieved with asymmetric Bronsted acid catalysis. The Morita- Baylis-Hillman (M-B-H) reaction, the coupling of activated alkenes with carbon electrophiles under the influence of a phosphine Lewis base, is an emerging carbon-carbon bond formation reaction for the formation of highly functionalized products. Although much research has been done to increase reaction rate and to expand substrate scope, an efficient and atom-economic asymmetric version has not been developed. Presented is the M-B-H condensation of aldehydes and a,b-cyclic ketones to give 3-hydroxy-2-methylene-carbonyl compounds in high enantioenrichments (up to 94%ee) and in moderate yields (40%-75%y.) using a cooperative catalyst system of a trialkylphosphine and an enantiopure, ortho-substituted binaphthol derivative as a chiral, Bronsted acid co-catalyst. This methodology allows for the use of M-B-H products as chiral synthetic precursors for synthesis of drugs and natural products.

O O OH O Phosphine (R'3P) R R1 H Chiral-Bronsted acid 1 n R n R1= alkyl, or aryl 3

OH OH

R3=H, halide, or aryl

31. Nucleotide Excision Repair from a Site-specifically Cisplatin-Modified Nucleosome Dong Wang, Ryujiro Hara, Gitanjali Singh, Aziz Sancar, Stephen J. Lippard Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Ave., 18-425 Cambridge, MA 02139

Nucleotide excision repair (NER) is a major cellular defense mechanism against the toxic effects of the anticancer drug cisplatin. In this study, mononucleosomes containing either a site-specific cisplatin-DNA intrastrand d(GpG) or an intrastrand d(GpTpG) cross-link were prepared. The effects of the histone proteins in the core nucleosome on the efficiency of NER of the well-defined platinum adducts were investigated as a model for exploring the cellular response to cisplatin damage in chromatin. Comparison of the repair signals of free and nucleosomal DNA containing the same cisplatin adduct indicates that the nucleosome significantly inhibits nucleotide excision repair. For a naked GTG-Pt DNA template, the excision signal in CHO cell free extract is about 10% of the total DNA, whereas for the nucleosomal GTG-Pt DNA, the excision signal is only 1.2%. For a naked GG-Pt DNA template, the excision signal is about 1.1% of total DNA, whereas for the nucleosomal GG-Pt DNA, the response diminishes to only 0.35%. The major GG-Pt and minor GTG-Pt cross-links are thus differentially inhibited, the relatively efficiencies are being 33% and 12%, respectively, for naked vs. nucleosomal substrates. The in vitro system established in this study will facilitate investigation of other cellular processing of the platinum-DNA damage at nucleosome level.

171 32. Synthesis of (5-cyanopentyl)-3-diazarine for use in outlining mechanistic details of nitrogenase catalysis Peter Germano and Edwin Jahngen University of Massachusetts Lowell, 76 West Street Pepperell, MA 01463

Nitrogenase is capable of reducing many small, unsaturated molecules and ions. The most important of these to biological systems is the reduction of atmospheric N2 to NH3. The mechanistic detail of this reduction pathway is still unclear. The use of alternative substrates serves as a useful adjunct in determining the chemical mechanism by which nitrogenase reduces its natural substrate. Diazirine is shown to be reduced to methane, methylamine, and ammonia in a ratio of ca. 1:2:4-5, with a Km of all three products similar to N2 (0.06-0.12 mM). HCN is an alternative substrate, which partially modifies the active site and has a very large comparative Km (4.5 mM). By synthesizing a substrate, (5-cyanopentyl)-3-diazirine (shown below), combining these two partial systems, elucidation of part of the chemical mechanism by which nitrogenase reduces its natural substrate may be resolved.

33. A Novel Copper Catalyzed Cycloaddition Coupling Reaction of Azides and Terminal Alkynes Baudouin Gerard, Aaron B. Beeler and John A. Porco, Jr. Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

A regioselective 1,3-dipolar cycloaddition/coupling process was developed for the formation of 1,4,5-trisubstituted triazoles employing a catalytic amount of Cu(CH3CN)4PF6, N,N- dimethylethylene diamine or N,N,N- trimethylethylene-1,2-diamine and NMO as cooxidant. Primary, secondary, and aromatic azides undergo smooth 1,3-dipolar cycloaddition with an excess of alkyne to yield 1,4,5-trisubstituted triazole in moderate yield which will be described in detail in this poster.

34. Synthesis of Novel Biologically Active Indolocarbazoles Sudipta Roy, Dr. Gordon Gribble, and Dr. Alan Eastman Dartmouth CollegeHanover, NH-03755

DNA damaging anticancer agents induce arrest at various checkpoints throughout the cell cycle. In search of inhibitors that abrogate cell cycle arrest in the presence of human plasma, Gö6976 was found to be one of the most potent checkpoint abrogator with far less cytoxicity. This observation led us towards the design and synthesis of the analogs of Gö6976 based on the structure-activity analysis and testing these novel compounds for activity against the protein kinases. The first analog ICP-103 (7-keto-Gö6976) has already been synthesized in our lab. Indeed, after testing it was found that ICP-103 is also a potent checkpoint abrogator. It showed comparable potency to abrogate S arrest and also to abrogate G2 arrest. ICP-101 and ICP-102 were intermediates in the synthesis which is closer to the structure of ICP-103 and but these compounds failed to abrogate cell-cycle arrest. To synthesize ICP-103, an earlier N-alkylation protocol was used followed by the coupling of two indole pieces.

172 35. New Tandem Catalysis. Preparation of Cyclic Enol Ethers through a Ruthenium-Catalyzed Ring Closing Metathesis-Olefin Isomerization Sequence Amanda E. Sutton, Benjamin A. Seigal, David F. Finnegan, and Marc L. Snapper Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

Tandem reactions that proceed with a single metal catalyst precursor offer novel opportunities for developing efficient new reaction sequences. In this regard, reaction conditions have been identified that allows for a tandem ring-closing metathesis-olefin isomerization sequence catalyzed by a common ruthenium precursor. Specifically, the tandem process generates cyclic enol ethers from a variety of readily available acyclic dienes in a single reaction vessel using Grubbs' ruthenium alkylidene.

36. An Approach to the Synthesis of Azaphilone Natural Products Using Cycloisomerization of o- Alkynylbenzaldehydes Jianglong Zhu and John A. Porco, Jr. Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

A number of natural products that have been isolated belong to the azaphilone family. These compounds have very interesting structures containing a highly oxygenated bicyclic core, as well as a quaternary center between two carbonyl groups. These azaphilones exhibit a wide range of biological activities, including kinase, telomerase, Grb2-Shc interaction inhibitory activities. Recently we have developed an acid-catalyzed 2-benzopyrylium salt formation via cycloisomerization of o-alkynylbenzaldehydes and in-situ oxidation to prepare the bicyclic core which will be discussed in this poster

37. Investigating SZ2 Energies of Protonation through Density Functional Theory and the QALE model W. Giering, A. Prock, J. Tourigny Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

38. Development of Thiazole Catalysts for the Asymmetric Stetter Reaction Jarred T. Blank, Michelle B. Tran, and Scott J. Miller Boston College, Department of Chemistry, 2609 Beacon Street, Chestnut Hill, MA 02467

The Stetter reaction was first reported several decades ago, but the first asymmetric variant appeared only recently. Nature approaches this carbon-carbon bond forming reaction with the use of Thiamine as a co-factor.

173 Inspired by such processes, we are undertaking a biomimetic approach toward finding a selective catalyst. Our research focuses currently on developing peptide catalysts incorporating thiazole containing amino acids to carry out a stereoselective selective Stetter. Catalysts were designed around a b-turn motif using an alklyated thiazole alanine as the reactive center. It was discovered that the first tetra-peptide delivered the product in 30% ee. Extensive investigation of the structure showed that thiazole alanine alone delivered the product in 42% ee. This simplified catalyst structure allows numerous modifications; this includes synthesis of b-substituted a-amino acids and a-substituted b-amino acids. Current efforts are focused on developing chiral thiazole catalysts to screen against a wide variety of additional substrates.

39. Pyridine receptor appended cyclidene "Molecular Tweezers" which reversibly bind dicarboxylic acids Jeremy S. Disch, Richard J. Staples, and Elena V. Rybak-Akimova Tufts University, Department of Chemistry, 62 Talbot Ave., Medford, MA 02155

Ni(II) cyclidene platforms of various ring sizes ([14]-, [15]-, [16]-) were synthesized and modified with pyridine arms [2-aminoethyl-(2-pyridine), picolyamine, and dipicolylamine] Binding studies of these new "Molecular Tweezers" with a series of dicarboxylic acids were studied by 1H NMR spectroscopy. The saddle shaped [16]- cyclidene variant shows improved 1:1 dicarboxylate binding, due to its folded nature, compared to the analogous flat [14]-cyclidene alternative. The conformationally flexible [15]-cyclidene shows intermediate binding characteristics. X-ray crystal structural comparisons of the host macrocycles will additionally be presented.

40. Exo2 as an Inhibitor of the Exocytic Pathway and as a Tool in Chemical Genetics. Richard D. Langfield and Gerald B. Hammond University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02747

The emerging field of chemical genetics stems from the integration of chemistry and biology; this approach identifies and manipulates small molecules in order to investigate the specific mechanism of biological pathways. The compounds active in inhibiting, or activating certain exocytotic pathways were identified in prior screening of chemical libraries. From this screening, Exo2 was found to perturb the endoplasmic reticulum (ER) to Golgi apparatus movement. The major objective was to find out how the action of Exo2 differed from that of a previously identified, and well known, compound Brefeldin A. Brefeldin A (Bref A) causes the Golgi to tubulate, and then redistribute its contents and membrane to the ER. Upon initial investigation Exo2 and Bref A act in the same way, that is to say they both stop the ER to Golgi transport, and cause the collapse of the Golgi. The question is does Exo2 cause the release of Arf1 into the cytoplasm before the collapse of the Golgi, as is the case with Bref A, or does Arf1 stay attached to the membrane during collapse. The findings of this study do show a difference in the action of Bref A and Exo2 with regard to the Arf1 protein.

174 41. Naphthoannulation: A New Procedure Patrick M. Donovan and Lawrence T. Scott Boston College, Department of Chemistry, Chestnut Hill, MA 02467

The 4-step naphthoannulation of thioxanthen-9-one (1) shown below gives the previously unknown sulfur heterocycle 4. Details of this procedure and its application to other diaryl ketones will be presented.

42. Active Site Characterizations of the Aromatic Amino Acid Hydroxylases; Understanding the Chemical Basis of Clinical Pathology SuzAnn Hertzler, S. Datta, H. Le, N. Mitic, J. Kemsley, J. P. Caradonna, E. I. Solomon Boston University, Department of Chemistry, 590 Commonwealth Ave., Boston, MA 02215

Phenylalanine Hydroxylase (E.C.1.14.16.1), Tyrosine Hydroxylase (E.C.1.14.16.2), and Tryptophan Hydroxylase (E.C.1.14.16.4) are non-heme, iron-dependent monooxygenases that require molecular oxygen and tetrahydrobiopterin for catalytic activity. These enzymes play essential roles in the biosynthetic pathways of neurotransmitters. Phenylalanine hydroxylase (PAH) serves to maintain L-phenylalanine homeostasis; a deficiency in PAH activity leads to hyperphenylalaninemia or, in more severe cases, phenylketonuria (PKU). Tyrosine hydroxylase (TYH) is the rate-limiting step in the biosynthesis of the catecholamine neurotransmitters; dopameric irregularities have been associated with disorders such as Parkinson's disease, Segawa's syndrome, bipolar disorders, and schizophrenia. Tryptophan hydroxylase (TrpH), which converts L-Trp to 5-hydroxytryptophan, catalyzes the first step in the biosynthesis of the neurotransmitter serotonin. Our lab has applied a variety of spectroscopic and kinetic techniques to investigate the mechanism and coordination environment of the iron active site of PAH. Multiple states of the allosteric enzyme have been spectroscopically (MCD, XAS, EPR) characterized in order to assess the influence of bound substrate and cofactor on the active iron site environment. In all states except one, PAH adopts a six coordinate geometry for both the ferric and ferrous forms. The exception is a five-coordinate square pyramidal structure of activated ferrous PAH, with cofactor and substrate bound, in which a bound water ligand is released. Analogous experiments have also been applied to two PKU-inducing mutants that are found in the western European population; expression and characterization of selected PKU-mutants can provide insight into the chemical basis of PKU. Comparable experiments have also been launched to investigate the mechanism and iron coordination environment of TYH. These studies would allow for chemical comprehension into the disorders associated with TYH deficiencies and permit comparative analyses of the hydroxylases.

43. Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems Christopher Crafts and Stephen M. Theberge Merrimack College, Department of Chemistry, 315 Turnpike Street, North Andover, MA 01845

175 determined simultaneously as proxies for the decomposition of organic matter. Profiles of dioxygen, iron(II), manganese(II), and several reduced sulfur species will be shown.

44. FT-EPR study of alkyl radicals photogenerated from alkylcobaloximes. Cecilia W. Kiarie, Debora M. Martino, and Hans van Willigen. University of Massachusetts Boston, Department of Chemistry, 100 Morrissey Blvd., Boston, MA 02125

Alkyl radicals photo-generated from alkylcobaloximes were studied using Fourier Transform Electron Paramagnetic Resonance (FT-EPR). Alkylcobaloximes are model compounds of vitamin B12 a coenzyme whose activity is attributed to the presence of a Co-C bond. There is evidence that the radical pair (RP) resulting from homolytic cleavage of this bond is important to the activity of the coenzyme. The objective of the present investigation was to contribute to the information on these RP’s through Chemically Induced Dynamic Electron Polarization (CIDEP) effects observed in FT-EPR spectra of alkyl radicals generated upon irradiation of alkylcobaloximes at 355nm. It was expected that the spectroscopic data would give an insight into the bond dissociation process particularly the spin state of the dissociative excited state. CIDEP patterns were strongly influenced by the nature of the solvent and axial ligand. This is an indication that the excited state involved in the bond cleavage reaction and the evolution of the geminate radical pair depends highly on the nature of the axial ligands and solvent-solute interactions. Therefore depending on the identity of the solvent and the axial base, the spin polarization pattern may be dominated by a contribution from a singlet excited state reaction channel or a triplet excited state reaction channel.

176 AUTHOR INDEX

Note: Presenting authors are in bold print Author Affiliation Page Ansaldo, Warren Boston University 15 Azev, Viatcheslav N. Tufts University 15 Beauregard, John Assumption College 14 Beeler, Aaron B. Boston University 26 Beierle, John Boston College 14 BelBruno, Joseph J. Dartmouth College 10, 23 Blank, Jarred T. Boston College 28 Bu, Lintao Boston University 24 Burin, Andrei Dartmouth College 10, 23 Caradonna, John P. Boston University 8, 14, 30 Connors, Lawreen H. Boston University 23 Costello, Catherine E. Boston University 23 Crafts, Christopher Merrimack College 10, 31 d'Alarcao, Marc Tufts University 15 Datta, S. Boston University 30 Deak, Holly L. Boston College 21 Del Sesto, D. F. Tufts University 12 Desmarais, Samantha Dartmouth College 20 Disch, Jeremy S. Tufts University 29 Dix, Edward J. Assumption College 11 Dominguez, Melissa M. C. Boston University 11 Donovan, Patrick M. Boston College 30 Dykstra, Andrew B. Boston University 23 Eastman, Alan Dartmouth College 27 Eastwood, Erin L. Boston University 18 Finnegan, David F. Boston College 27 Foster, Trina L. Boston University 8, 14 Gao, Yang Boston University 20 Georgiadis, Rosina M. Boston University 20 Gerard, Baudouin Boston University 26 Germano, Peter UMass Lowell 26 Giering, Warren P. Boston University 9, 15, 28 Giguere, Joshua R. Boston University 13 Gribble, Gordon Dartmouth College 27 Hammond, Gerald B. Umass Dartmouth 29 Han, Chong Boston University 17 Hara, Ryujiro M.I.T. 25 Herrera, Aida M. Tufts University 17 Hertzler, SuzAnn Boston University 30 Huetsch, John Harvard University 13 Jahngen, Edwin UMass Lowell 26 Jamison, Timothy F. M.I.T. 22 Kelley, Shana O. Boston College 8, 17 Kelly, T. Ross Boston College 14 Kemsley, J. Boston University 30 Kiarie, Cecilia W. UMass Boston 31

177 Killelea, Dan R. Tufts University 12 Korendovych, Ivan V. Tufts University 9, 21 Kryatov, Sergey V. Tufts University 17, 18 Kull, F. Jon Dartmouth College 20 Kumar, Krishna Tufts University 22 Lahue, Brian Boston University 16 Langfield, Richard D. Umass Dartmouth 29 Le, H. Boston University 30 Li, Ziman Boston University 24 Lim, Amareth Boston University 23 Lippard, Stephen J. M.I.T. 25 Martino, Debora M. UMass Boston 31 McDougal, Nolan T. Boston University 25 Mearn, Marianne Assumption College 14 Metallinos, Costa Boston College 14 Miller, Karen M. M.I.T. 22 Miller, Scott J. Boston College 28 Mitic, N. Boston University 30 Mullin, Amy S. Boston University 24 Niece, Brian K. Assumption College 11 Nussbaum, Brooke Tufts University 22 O'Keefe, Meaghan Boston College 8, 17 Osumboni, Ekundayo Boston College 14 Pandya, Bhaumik A. Boston College 19 Porco, John A., Jr. Boston University 17, 26, 28 Prock, Alfred Boston University 9, 15, 28 Reiff, William M. Tufts University 9, 21 Roy, Sudipta Dartmouth College 27 Ruthenburg, Alex Harvard University 13 Rybak-Akimova, Elena V. Tufts University 9, 15, 17, 18, 21, 29 Sancar, Aziz M.I.T. 25 Schaus, Scott E. Boston University 11, 12, 13, 18, 25 Scott, Lawrence T. Boston College 30 Seigal, Benjamin A. Boston College 27 Shen, Ruichao Boston University 17 Singh, Gitanjali M.I.T. 25 Skinner, Martha Boston University 23 Smith, R. R. Tufts University 12 Smyla, Lauren M. Boston University 13 Snapper, Marc L. Boston College 19, 21, 27 Snyder, John K. Boston University 16 Solomon, E. I. Boston University 30 Staples, Richard J. Tufts University 9, 17, 21, 29 Straub, John E. Boston University 24 Sutton, Amada E. Boston College 27 Taft, Bradford J. Boston College 8, 17 Taktak, Sonia Tufts University 18 Theberge, Stephen M. Merrimack College 10, 31 Tourigny, Justin Boston University 9, 28 Tran, Michelle B. Boston College 28

178 Turner, Adam W. Assumption College 11 Utz, A. L. Tufts University 12 van Vloten, Kurt UMass Boston 19 van Willigen, Hans UMass Boston 31 Verdine, Greg Harvard University 13 Walsh, Mary T. Boston University 23 Wan, Zhao-Kui Boston University 16 Wang, Dong M.I.T. 25 Westbrook, John Boston University 12 Williams, Michael J. Boston College 21 Wolf, Lauren K. Boston University 20 Woo, Grace Boston University 16 Xia, Bing Boston University 11 Zhao, Yajun Boston College 14 Zhu, Jianglong Boston University 28

179 Complete Program: Connections to Chemistry

Connections to Chemistry

Burlington High School Burlington, Massachusetts October 8, 2003

Sponsored by the Northeastern Section of the American Chemical Society

180 The American Chemical Society and The Northeastern Section

The American Chemical Society (ACS) is the largest scientific organization in the world that is devoted to a single discipline –chemistry– with more than 160,000 members at all degree levels. Among its members are teachers that span the entire spectrum of chemical education: high schools, two- and four-year colleges, and research universities. The specific interests of the members of the ACS are reflected in the activities of the 34 technical divisions, such as the divisions of Organic Chemistry, Biological Chemistry, Computers in Chemistry, Chemical Education, and the History of Chemistry.

The membership in the Division of Chemical Education (DivCHED) is open to anyone who has an interest in chemical education, including those who teach chemistry in high schools, community colleges, 4-year colleges and universities; membership also includes chemists in industry, government, and foundations. DivCHED publishes the Journal of Chemical Education, which is a monthly journal for all teachers of chemistry, from K–16 and beyond. In addition, DivCHED offers programs for teachers and students to further enhance the learning of chemistry and the future of the profession. For more information, visit the American Chemical Society website at http://www.acs.org.

The ACS has more than 180 local sections of which the Northeastern Section (NESACS) is one of the largest, with almost 6,000 members, encompassing Eastern Massachusetts and New Hampshire. NESACS holds monthly meetings and offers a wide range of technical and social programs for younger chemists, retirees, and all those in between. The Education Committee of NESACS sponsors programs for high school and college students, and programs for chemistry teachers and others who have an interest in chemical education. For more information, visit the NESACS website at http://www.nesacs.org.

181 Program Schedule

Connections to Chemistry

October 8, 2003

3:30 – 4:00 p.m. Registration and Refreshments Main Lobby, Burlington High School

4:00 – 4:25 p.m. Welcome, Overview, and Review of the Sessions (Auditorium) Ruth Tanner, Chair, Education Committee, NESACS Professor of Chemistry, University of Massachusetts Lowell

Morton Hoffman, Program Chair, Division of Chemical Education, ACS Professor or Chemistry, Boston University

Steve Lantos, Chair, High School Education Committee, NESACS Chemistry Teacher, Brookline (MA) High School

4:30 – 6:10 p.m. Four Simultaneous Workshops in Two Sessions: Session I: 4:30 – 5:15 Session II: 5:25 – 6:10

Workshop A: Performing Effective Chemical Demonstrations (Room 172) John Mauch, Braintree High School and Chair of the High School Committee, ACS Division of Chemical Education with Linda Weber, Natick High School

Workshop B: Liability in the Laboratory and Classroom (Room (Room 157) Attorney Sarah Gibson, sponsored by the Massachusetts Teachers Association

Workshop C: NCW, Will a Match Burn in the Absence of Gravity? (Room 176) Thomas Gilbert, Associate Professor of Chemistry and Education, Northeastern University

Workshop D: Exploring Quantum Concepts in Chemistry (Room 177) Alan Crosby and Associates, Department of Chemistry; and Peter Garik, School of Education, Boston University (A two session workshop, 4:30 - 6:10)

6:15 – 6:55 p.m. Dinner (High School Cafeteria)

7:00 –7:45 p.m. Address (Auditorium) Around the World on 37 Cents! Or How to Find Unusual Resources for Teaching Sally Mitchell, Recipient of the Northeast Regional ACS Outstanding High School Teacher Award

182 Keynote Address

Mrs. Sally Mitchell

Sally Mitchell is a chemistry teacher at East Syracuse-Minoa High School in East Syracuse, New York. She is teaching chemistry to advanced high school students. In addition, she is the Regional Director of the Science Olympiad, the coordinator for Chemagination for the Syracuse Section of the ACS, and a state supervisor for a middle school event called Can’t Judge a Powder by its Color. Among her numerous awards, she has been the mole of the year for the National Mole Day Foundation from 2001-2003, and was the recipient of the Northeast Regional ACS outstanding High School Teacher Award in 2003. Sally received a BS in Chemistry and Biology and a MS in Science Education from Syracuse University.

Sally has had a significant and positive influence on the national chemical community, through both her exemplary contribution to high school chemistry teaching and her public service. For 20 years, she has been a passionate educator, giving presentations at national conferences and science museums, headlining workshops, presenting chemical demonstration programs, coaching chemistry clubs, and working with college students on outreach activities. Affiliation with a major airline enabled her to visit science museums around the globe, shaping her view of chemistry as a dynamic science – a belief with which she motivates both her students and colleagues through her humor, encouragement, enthusiasm, and pursuit of excellence.

Around the World on 37 Cents! How to Find Unusual Resources for Teaching

There are many opportunities for high school teachers to get involved with other chemists, with outside school activities and with college programs. Food Science has been a connecting tool to entice students to have a love of chemistry. The connection to the stomach has always churned up many new and exciting ideas. The chemistry from the National Science Olympiad can be incorporated into the laboratory through qualitative analysis, laboratory instrumentation, polymer study, and most recently forensics. Forensic chemistry is the hottest subject being taught. High school chemistry clubs can be connected to college programs and industrial programs. Development of integrated programs in conjunction with cosmetology, culinary institutes and auto shop departments can be the spark students need to become excited about chemistry. What are your students’ interests? Incorporate chemistry into them.

183 National Chemistry Week

Celebrate National Chemistry Week October 19-25, 2003

National Chemistry Week (NCW) provides an opportunity for your students to share the fun and relevance of chemistry with members of their school and neighborhood communities. It also provides a way for them to share in a nation-wide celebration of Chemistry. Teachers can participate in NCW by holding events that focus on celebrating this year’s theme Earth’s Atmosphere and Beyond. The October issue of ChemMatters, the ACS magazine for high school students, contains articles and activities that reflect this theme. The October issue of the Journal of Chemical Education also features articles about the chemistry of cleaning, and lists numerous resources

As part of the National Chemistry Week 2003 celebration, the Northeastern Section of the American Chemical Society (NESACS) will sponsor a daylong program at Wellesley College on Sunday, October 19, 2003. Chemistry demonstrations regarding Earth’s atmosphere, and hands-on activities will be featured at the Wellesley Science Center. A special presentation of chemical demonstrations will be given by Dr. Bassam Shakhashiri at 11AM – noon and repeated from 2 PM – 3 PM; the presentations are free; seating is on a first-come, first-served basis. Dr. Shakhashiri is a Professor of Chemistry at the University of Wisconsin-Madison and is well known for captivating audiences with his scientific demonstrations.

In addition to the program at Wellesley College, the NESACS will sponsor a program at MIT entitled What’s New in the Air? Atmospheric Chemistry in the 21st Century. It will being at 7:00 PM in the Eastman Lecture Hall, Room 6-120 and will feature several prominent atmospheric scientists from MIT and Harvard University.

For more information on the National Chemistry Week programs for the Northeastern Section, go to http://www.nesacs.org.

184 Workshops

185 Workshop A: Performing Effective Chemical Demonstrations

John Mauch and Linda Weber will present some of their favorite demonstrations with tips about how to safely perform demonstrations in your chemistry classroom. ACS guidelines will be discussed.

After the demo presentations, participations will have a chance to practice some demonstrations using kits provided by Flinn Scientific. The demo kits cover a wide range of topics from chemical reactions, colloids, acid-base reactions, kinetics and equilibrium.

· Orange Juice to Strawberry Float: Change a glass of orange juice to a strawberry float. Mix the chemicals and a huge mound of foam will erupt out of the glass. Kids love it! (Acid-base indicators, neutralization reactions) · Rainbow Out of the Blue: Produce an entire spectrum of color by adding blue food coloring to varying concentration of acid solutions. Then discuss wavelengths of light absorbed by the dye and the color observed. (Acid-base indicators, light absorption, spectrum) · Four Square Diffusion: An easy way to demonstrate diffusion, vapor pressure intermolecular forces, and Raoult’s Law by sprinkling a few crystals into the opposite quadrants of a divided Petri dish. (Equilibrium, diffusion, sublimation and Raoult’s Law) · Hot and Cold Equilibrium: Pour some violet-colored solution into three different test tubes. Place one of the test tubes in hot water and one in cold water. The hot turns deep blue from the top down; the cold turns pink from the bottom up. The room temperature remains violet. Then reverse the tubes in the baths and watch what happens. (Equilibrium, LeChatelier’s Principle) · ROY G BIV Clock Reaction: Seven different dry chemicals added to separate beakers and a colorless liquid is added; in less than a minute a large pH change at the end of this clock reaction causes a blooming of seven rainbow colors. (acid-base buffers, clock reactions, pH) · Four-Color Oscillator: Measure and mix four solutions together. In about 10 seconds the solution turns from green to blue and then purple followed by red. It repeats itself for about an hour! (oscillating reactions, equilibrium) · Reversible Orange and Blue Reaction: Easy to do demo where a warm, clear blue solution starts to bubble and suddenly turns an opaque orange color when the temperature increases and bubbling becomes vigorous. The change repeats itself several times. (Redox reactions) · Polyurethane Foam: Mix two viscous liquids together and watch as the mixture expands to about 30 times its original volume. (polymers, catalysts) · Chemical Kidney: Tell a story as you perform this demo. Mix various ingredients with water and watch the solutions change from red wine to lemonade to grape juice to finally a distinct yellow color. (complex ions, chemical reactions) · Aloha Sunset: Watch the sunset over a beautiful Hawaiian Island as light passes through a colloidal suspension is affected by the size of the particles. (colloids, precipitates, Tyndall effect) · Flaming Vapor Ramp: Are volatile, flammable liquid vapor heavier than air? Find out with this demonstration. (combustion, fire safety)

Placement within the chemistry curriculum, demonstration styles and other ideas will be discussed with the workshop participants.

186 Workshop B: Liability and Litigation

Every science teacher’s nightmare is an accident in a laboratory or a classroom that injures one or more students. Increasingly, we assume that where there is an accident, litigation and liability will soon follow. But is that assumption accurate?

This workshop will review the laws, regulations, and court cases that govern teachers’ health and safety obligations, and the consequences if teachers do not meet those obligations. The discussion led by Attorney Sarah Gibson, a lawyer provided by the Massachusetts Teachers Association, will include:

What’s the worst case?

· potential liability resulting from statutes and regulations concerning hazardous materials handling

· potential liability for lab accidents, generally

· consequences of health and safety problems for teachers’ employment security, certification, and pensions

Prevention

· how can science teachers minimize their own liability and maximize the safety of their classes and labs?

· dealing with uncooperative students

· dealing with uncooperative or inattentive administrators

The goal of this workshop is to give science teachers an overview of the statutes and regulations that apply to health and safety in laboratories, explain how liability may be attributed in cases of failure to safeguard students’ well-being, and how to avoid litigation altogether.

187 Workshop C: Earth’s Atmosphere and Beyond

Humans have wondered about “sky things” for millennia. Stars mesmerize us! What are they made of? How do we know? Even understanding our own atmosphere is a relatively new field in science. It was only a couple hundred years ago that the concept of air and oxygen were even described by Priestly and Lavoisier.

The National Chemistry Week workshop includes three experiments emphasizing physical and chemical properties of planetary and celestial atmospheres led by Professor Thomas Gilbert from the Department of Chemistry at Northeastern University and assisted by Jerusha Vogel, a high school chemistry teacher at Lexington High School.

The first will address the dynamics of cloud formation: Temperature, pressure, and particulate matter all effect cloud formation. Household items will be utilized in Bob Becker’s experiment of making clouds in a 2-L plastic bottle. Mr. Becker’s experiment is published the October, 2003 issue of ChemMatters as part of the American Chemical Society’s National Chemistry Week activities.

The second experiment is based on the chemical reaction between CaCl2 (sidewalk deicer) and NaHCO3 (baking soda). These solids are added to opposite corners of a Ziploc bag. Then a small plastic cup containing about 25 mL of water and a few drops of universal indicator is placed in the bag. The bag is sealed, and it and its contents are weighed. Then the cup is allowed to tip over onto the pile of baking soda. After the baking soda dissolves and the indicator changes color, this solution is mixed with the calcium chloride. A chemical reaction ensues, the reactions mixture changes temperature, the indicator changes color, and the bag inflates. After the reaction is complete the bag is reweighed and, voila, it is about a gram lighter.

The many measurements and observations that can be made before, during and after this reaction allow teachers to bring together topics in thermochemistry, acids and bases, gas pressure, and the law of conservation of mass. Students’ attempts to explain where the missing gram “went” provide opportunities to examine the own understanding of, or misconceptions about, physical laws, the meaning of “mass” vs. “weight”, the notion of buoyancy, and the density of Earth’s atmosphere.

The third experiment introduces students to how scientists know the components of an atmosphere. How do we measure what we can’t see or can’t touch? How do we know we have an ozone hole? How do we know that the Martian atmosphere is primarily carbon dioxide? How did 19th century scientists discover that the sun contains helium, a relatively rare gas here on Earth? We will use diffraction gratings and spectroscopes to look at fine line spectra in visible light, and then provide an opportunity for those who are interested to learn about the spectroscopic observations of Hubble and others that led to profound changes in how we view the dynamics of the universe and the manner of its creation.

188 Workshop D: Exploring Quantum Concepts in Chemistry

Peter Garik, Daniel Dill, Morton Hoffman, Alan Crosby, Alex Golger, Luciana Garbayo and Peter Carr, Boston University

Quantum concepts are the foundations of our modern understanding of chemistry. An introduction to these concepts is standard fare in many introductory chemistry textbooks, with students leaving high school with an Aufbau recipe of s, p, d, and f orbitals coupled to principal quantum numbers engraved in their minds along with images of bulbous geometrical figures. Parallel to their introduction to atomic structure, but disconnected from it, students are introduced to a host of heuristics: the octet rule, Lewis dot structures, electronegativity, periodicity, and so on, for explaining bonding. What is missing for the students is what makes the quantum model of the atom so powerful: the connections between quantum concepts and atomic structure and molecular bonding. Instead of finding unity in the quantum model, students frequently emerge in a fog concerning wave-like particulate electrons.

The goal of the Exploring Quantum Concepts in Chemistry Project is to provide instructors with software tools that can be used by students to investigate the underlying unity of atomic and molecular structure from a quantum perspective. In this workshop we will model the use of three programs that we have developed:

· The Atomic Explorer provides students with representations of the orbitals for hydrogen through xenon. The displays include two and three-dimensional representations of the orbitals, an energy level diagram for all electrons in the atom, and a display of the average electronic radius. Either orbital amplitude or the electron density can be displayed.

· The Bond Explorer simulates how two nuclear centers, each with a single orbital, share a single electron. The relative energies of the two orbitals as well as the symmetry of the orbitals can be varied by the user.

· The Diatomic Explorer offers students the opportunity to study the molecular orbitals that arise from the bonding between the simpler elements. Students can study sigma and pi bonding, the dipole moment that arises, as well as trends in the nature of the bonds and the electronic distribution around the atoms.

In the workshop we will provide a tour of this software with applications to standard issues that arise in the curriculum. After many prior workshops with teachers and college instructors, it is our experience that many instructors do not explicitly use the unifying power of quantum ideas to simplify chemistry for their students. We will try to emphasize the ways that this can be done.

The work for this project is funded by the U.S. Department of Education’s Fund for the Improvement of Post Secondary Education (FIPSE), Award No. P116B020856. Earlier work for this project was funded by the National Science Foundation.

189 Thank You

We gratefully acknowledge the contributions of the following organizations and individuals for their support of the 2003 Connections to Chemistry program. We would like to extend our special thanks to Burlington High School for hosting this program.

Program Conference Committee

Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Chair, NESACS, Boston University Susan Buta, Chemistry Faculty, Lincoln-Sudbury (MA) Regional High School Steve Lantos, Chemistry Faculty, Brookline (MA) High School Jerusha Vogel, Chemistry Faculty, Lexington (MA) High School

Planning and Program Associates

Sarah Iacobucci, National Chemistry Week Committee, NESACS; Tufts University Christine Jaworek, Chair, National Chemistry Week, NESACS; Emmanuel College Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Nancy Spicer, Research Scientist, Industrial Consultant Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell John Riley, Membership Chair, Chemistry and the Law, American Chemical Society

Material Assistance

Lin Morris, Assistant Editor, Journal of Chemical Education Helen Herlocker, Manager, Office of High School Science, ACS, (ChemMatters) Robin Giroux, Assistant Managing Editor, Editing & Production, Chemical & Engineering News William Robinson, Chair, Division of Chemical Education, ACS Marilou Cashman, Executive Secretary, NESACS

Publicity Support

New England Association of Chemistry Teachers (NEACT) Massachusetts Association of Science Supervisors (MASS) Massachusetts Association of Science Teachers (MAST) The Nucleus (NESACS)

190 Registered Schools

Massachusetts Massachusetts

Milton High School Natick High School Minuteman Regional High School Needham High School Mt. St. Joseph Academy Newton Country Day School Ayer High School North Andover High School Barnstable High School North High School Belmont High School North Middlesex Regional High School Berwick Academy North Reading High School Beverly High School Notre Dame Academy Billerica Memorial High School Oliver Ames High School Bishop Fenwick High School Pingree School Bishop Stang High School Poland Regional High School Boston Latin Academy Pope John XX111 High School Boston Latin School Portsmouth Christian Academy Bridgewater Raynham Regional High School Presentation of Mary Academy Brookline High School Sandwich High School Calvary Christian School Sharon High School Central High School St. Mark's School Chelmsford High School Stoughton High School Dana Hall School Tech Boston Academy Danvers High School Tewkbury Memorial High School Dover Sherborn Regional High School West Roxbury High School Duxbury High School Westford Academy Fontbonne Academy Weymouth High School Gloucester High School Woburn High School Groton Dunstable Regional High School Wocester Academy Hingham High School Holliston High School Hopkinton High School New Hampshire Hudson Catholic High School Hull High School Bishop Guertin High School John Stark High School Concord High School Lawrence Academy Franklin Pierce College Lexington High School Goffstown Area High School Lynnfield High School Londonderry High School Malden High School Manchester Central High School Malden Catholic High School Monadnock Regional High School Mansfield High School Oyster River High School Medfield High School Pinkerton Academy Medford High School Somersworth High School Methuen High School Milton High School Minuteman Regional High School Connecticut Mt. St. Joseph Academy N. Middlesex Regional High School Naugatuck High School

191 National Chemistry Week Earth’s Atmosphere and Beyond!!

Phyllis A. Brauner Memorial Lecture by Dr. Bassam Shakhashiri

Dr. Bassam Shakhashiri is a Professor of Chemistry at the University of Wisconsin-Madison and is the William T. Evjue Distinguished Chair for the Wisconsin Idea. Professor Shakhashiri has captivated audiences with his scientific demonstrations at a varitety of locations including Boston’s Museum of Science, the National Academy of Sciences and the Smithsonian's National Air and Space Museum in Washington.

Sunday, October 19, 2003 11 am – 12 pm repeated from 2 pm – 3 pm Wellesley College, Science Center, Room 277 The Sunday presentations are free and open to the public. Tickets are available on a first come, first serve basis though reservations are recommended. To reserve tickets, please contact Marilou Cashman either via email [email protected] (preferred) or by phone 1-800-872-2054. Tickets will be available for pick-up outside of the Science Center on the 19th. Parking is free. For directions to Wellesley College, please visit http://www.wellesley.edu/Admin/travel.html. While at Wellesley, a visit to the arboretum and greenhouses (which are open to the public) is a must. For more information, visit http://www.wellesley.edu/FOH/greenhouse.html.

192 ANNUAL REPORT Northeastern Section, ACS

APPENDIX 6 YOUNGER CHEMISTS COMMITTEE REPORT

http://www.nesacs.org

193 APPENDIX 6 - YCC REPORT

Northeastern Section LSYCC Annual Report 2003 Submitted by Lauren K. Wolf, Chair NSYCC 2003-2005 (follows format prescribed by ACS)

I. Overall Evaluation

For the Northeastern Section Younger Chemists Committee (NSYCC), 2003 was a very pivotal and successful year. Dr. Amy Tapper, Chair of the Committee from 1999-2003 stepped down early in the year to pursue other local section positions and interests. We are proud to announce that Amy is now Chair-Elect of the NESACS for 2004.

As such, the YCC goals for 2003 primarily involved finding new officers, growing the committee, becoming more organized, and continuing all of the wonderful programs established in years past. These goals were all accomplished readily. New officers were put into position from a variety of universities and backgrounds (see below). The Northeast Student Chemistry Research Conference (NSCRC) 2003 subcommittee also saw its largest, most diverse membership since the start of the conference in 1999. The annual Career Symposium, German Exchange Program, and NSCRC were all continued successfully, attracting new members and giving the new NSYCC officers ideas for future program improvements.

In addition, the NSYCC hired a graphic artist to design a new, more organized website. The design and content took four months to finish, but we are happy to announce its completion as of January 2004 (see www.nsycc.org). The new site highlights all of the annual activities organized by the YCC, providing photos, schedules, and other detailed information from past programs. Younger chemists will be able to register for upcoming career fairs and submit abstracts for upcoming student research conferences through the website. The site also features a current news page where younger chemists can get updated information on monthly activities (such as the NESACS monthly meetings) and a “Sign-Up” for new members to be added to our mailing list.

II. Officers and Members

The Annual Report is submitted by the NSYCC Chair each year.

LSYCC Officers

Lauren K. Wolf – Chair Department of Chemistry Boston University 590 Commonwealth Ave., Boston, MA 02215 [email protected] (617)353-3241

Ivan Korendovych – Assistant Chair Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 [email protected] (617)627-5745

194 Sonia Taktak – Treasurer Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 [email protected] (617)627-5745

Aida Herrera – Career Chair Department of Biological Engineering Massachusetts Institute of Technology 77 Massachusetts Ave., Cambridge, MA 02139 [email protected] (617)253-5772

Slava Azev - Webmaster Department of Chemistry Tufts University 62 Talbot Ave., Medford, MA 02155 [email protected] (617)627-2042

YCC Mentors

Dr. Amy Tapper – Past YCC Chair Genzyme Drug Discovery and Development 153 Second Ave. Waltham, MA 02451 [email protected] (781)434-3518

Dr. Michael Strem – Chair of German Exchange Steering Committee Strem Chemicals, Inc. [email protected]

Dr. Ruth Tanner – Chair of NESACS Education Committee University of Massachusetts Lowell [email protected]

Dr. Morton Hoffmann – Past NESACS Chair Boston University [email protected]

YCC Members

Northeast Student Chemistry Research Conference (NSCRC) 2003 Subcommittee

Co-Chairs: SuzAnn Hertzler Boston University [email protected] Lauren Wolf Boston University [email protected]

Webmaster:

195 Lintao Bu Boston University [email protected]

Program and Printing: Truc Diep Boston University [email protected] Dawn Troast Boston University [email protected]

Gifts and Journals: Aida Herrera Tufts University [email protected] Ivan Korendovych Tufts University [email protected] Sonia Taktak Tufts University [email protected]

Set-up and Arrangements: Erin Eastwood Boston University [email protected] Christina Fields Harvard University [email protected] Justyna Kucharczak Boston University [email protected] Jennifer Levine Boston University [email protected] Karen Miller MIT [email protected]

III. Activities

Schedules, photographs, and detailed information about each of this year’s activities are available on the new NSYCC website, www.nsycc.org.

Career Symposium 2003: Alternative Careers in Chemistry

The annual YCC Career Symposium was held on February 14, 2003 from 3:30-5:30pm prior to the NESACS monthly meeting at the Holiday Inn in Newton, MA. This year’s theme was selected to introduce younger chemists to a variety of non-traditional careers in chemistry. These careers require the knowledge and skills of a chemist, but exist outside of the traditional laboratory setting. In today’s competitive job market, it is important for younger chemists to know about such career alternatives.

The speakers at the symposium were Jack Cunniff (Thermo Finnigan – Regional Sales Manager), Vinkey Moroak (Biogen – Clinical Project Manager), Michael Strem (Strem Chemicals – President), Melissa Huang (Rhodia Chirex – Business Development Manager), Darlene Vanstone (Geltex Pharmaceuticals – Senior Patent Counsel), and Christopher Doona (US Army, Natick – Leader of the Combat Feeding Innovative Team). Each of these speakers shared their personal career experiences and answered questions from the attending students. The informal atmosphere of the symposium, coupled with the interesting “how I got here” stories from the speakers, made the symposium a great success. In the future, however, the YCC will invite fewer speakers and allot more time per speaker, as there wasn’t enough time to take all student questions. There were 20-30 younger chemists in attendance, many of whom stayed for the NESACS monthly meeting and dinner.

NESACS-YCC/GDCh-JCF Exchange Program

196 Saturday February 22: Depart from Boston in the evening.

Sunday February 23: Arrive in Munich in the morning. Sight-seeing in Downtown Munich – informal tour by JCF-Munich representatives. Lunch at traditional Bavarian restaurant near Marienplatz. Evening trip to famous Hofbrauhaus. Group Dinner at the Ratskellar (Rathaus).

Monday February 24: Morning tour of laboratories and NMR facility at Munich Technical University, Garching. Afternoon International Career Symposium at the University. Speakers include Dr. Elsa Reichmanis (ACS President 2003), Dr. Stefan Buchholz (Degussa AG), and others. Group Dinner at traditional Bavarian restaurant sponsored by Degussa.

Tuesday February 25: Morning trip to Munich Deutches Museum (science museum). “Behind-the-scenes” tour of chemistry exhibits in museum Afternoon free time. Evening lecture by Dr. Elsa Reichmanis at the Ludwig Maximilian University.

Wednesday February 26: Bus trip past Alps to Wacker-Chemie GmbH (Burghausen). Morning lectures on Wacker production. Tour of plant and Siltronic facility at Wacker. Lunch hosted by Wacker in private dining room. Afternoon lectures on global business opportunities. Flight from Munich to Dresden. Evening dinner with JCF representatives in downtown Dresden.

Thursday February 27: Morning/afternoon free time. Evening welcoming lectures for the Euregionale student research conference held at Dresden Technical University. Evening Euregionale student research poster session. Dinner buffet for Euregionale participants at the University.

Friday February 28: Morning student oral research presentations at Euregionale. Afternoon student research poster session. Evening student party/dinner buffet hosted by JCF.

Saturday March 1: Morning student oral research presentations at Euregionale. Euregionale awards presentation. Afternoon group sight-seeing tour of downtown Dresden. Evening farewell dinner at Pulverturm in downtown Dresden.

Sunday March 2: Return to Boston.

197 student research conference in Dresden. The remaining students presented posters. They represented the Northeastern Section well and were nominated in three of the four possible award categories at the Euregionale. A report was written by two of the participating students and was published in The Nucleus (the NESACS monthly newsletter). The article, as well as photographs and programs, can be found on our new website under “German Exchange 2003.”

Northeast Student Chemistry Research Conference (NSCRC)

The Fifth Annual NSCRC took place at Boston University on Saturday, April 26, 2003. The event, located in the Metcalf Center for Science and Engineering, attracted approximately 80 participants from schools in the Boston area. Of these participants, record percentages of students from both Tufts University (15%) and Boston College (10%) were in attendance. As the host institution, Boston University had the largest representation (40%).

The event featured six graduate/undergraduate oral presentations and 44 poster presentations. Free online journal subscriptions, donated by the ACS, were awarded to the best graduate and undergraduate presentations. These awards were as follows:

Best oral presentation Ivan V. Korendovych (Tufts University) “Iron complexes with pentadentate macrocyclic ligands as potential enzyme mimics” Best graduate poster presentations Karen M. Miller (MIT) “Asymmetric Catalytic Reductive Coupling of Alkynes and Aldehydes” Patrick M. Donovan (Boston College) “Naphthoannulation: A New Procedure” Best undergraduate poster presentations Andrew B. Dykstra (Boston University) “Investigation of Sequence Variation and Posttranslational Modification of Light Chains Isolated From Patients Diagnosed With Light Chain-Associated Diseases” John Beierle (Boston College) “Synthesis of Louisianin C”

In addition, the Brauner Undergraduate Book Award, sponsored by the Education Committee of NESACS, was presented by Dr. Ruth Tanner of UMass Lowell. The award went to an undergraduate student who gave an oral presentation at the conference:

Christopher Crafts (Merrimack College) “Fabrication and Deployment of Solid-State Microelectrodes in Natural Systems”

A slideshow about the NESACS-YCC/GDCh-JCF German-Exchange Program and 2003 Trip to Munich and Dresden was given by 6 of the 12 American participants in this year’s exchange. The presentation featured pictures from the trip itself and information on how students in the area can get involved in the exchange program in 2004 and 2005.

198 The keynote address, entitled “Nanowires as Building Blocks for Nanoscale Science and Technology: Building a Big Future from Small Things,” was given by a post-doctoral student, Deli Wang. Deli gave the address in place of Dr. Charles Lieber of Harvard University, who fell ill the day before the conference. To show appreciation to Deli for giving the keynote address, the NSCRC committee presented him with a desk clock engraved with the name and date of the conference.

The NSCRC 2003 was a great success in terms of attracting new students and improving organization. The Science and Engineering Center where the conference was held, however, is not really adequate for an event of this size. Next year, the YCC hopes to find a larger, more attractive venue to support twice the attendance. In order to achieve this increase in attendance, we would also like to organize a more professional advertising campaign. In addition, we would like to obtain financial support from area companies to sponsor cash prizes for student posters and talks.

IV. Budget

February Career Symposium $200.00 NESACS-YCC/GDCh-JCF German Exchange Program $5247.60 The 5th annual NSCRC (co-sponsored by Education Committee) $2129.02 Website (www.nsycc.org) Design $1000.00

Total Expenses $8576.62

The source of all funds was the Northeastern Section of the American Chemical Society (NESACS).

V. Future Plans

The NSYCC has begun organization of our 4th annual Career Symposium, to be held February 12, 2004 at Boston College. The theme of the symposium will be “Careers in Communicating Science and Chemistry” and will feature a professor from Tufts University, a Pulitzer Prize-winning science writer, and a scientific staffing professional. Each speaker will discuss different aspects of communicating science and chemistry to students, the public, and potential employers.

We have also begun plans for the 4th annual exchange between the NESACS-YCC and the GDCh-JCF. This year, we will host 13 German students during the week of April 18, 2004 in Boston. The students will visit the Whitehead Institute, the Museum of Fine Arts, Harvard University, and a Northeastern pharmaceutical company. In addition, they will take in the Boston Marathon, a Red Sox game, and a performance of the Boston Symphony Orchestra. The last full day of the week’s exchange (April 24th) will coincide with the 6th annual Northeast Student Chemistry Research Conference (NSCRC). The German students will participate in the conference by presenting research posters and talks. The keynote address of the conference this year will be given by Dr. Stephen J. Lippard of MIT. Closing remarks and awards will be presented by ACS President 2004, Dr. Charles P. Casey.

The NSYCC has also planned the first Northeast Student Chemistry Career Fair (NSCCF), to be held during the week of the exchange on April 23, 2004. The event will feature morning workshops on resume writing and interviewing skills, given by ACS Career Services. During the afternoon job fair, student attendees will be given the opportunity to meet representatives from Northeastern companies to discuss employment.

Beyond April 2004, the NSYCC plans to participate in National Chemistry Week 2004 and hold Summer and Fall social/networking events. We will strive to become an organization that younger chemists in the region recognize and respect. We want to become a stronger presence in the NESACS

199 and represent the interests of younger chemists in the Northeast. We will continue to work to help students and young professionals along their career paths by involving them in national and local society events. The NSYCC will also support the professional advancement of younger chemists by working to form a network with representatives from companies in the Northeast, connecting them with our members.

200 ANNUAL REPORT Northeastern Section, ACS

PART III

ANNUAL FINANCIAL REPORT

http://www.nesacs.org

201 PART III - ANNUAL FINANCIAL REPORT

Part A. Statement of Revenues and Expenses Operating Fund Part B. Balance Sheet as of 12/31/03

For financial statements, please see report filed online with the National ACS office.

http://www.acs.org

Addendum to Annual Financial Report - 2003

NORTHEASTERN SECTION Attachments to 2003 Financial Report

Line 10 Other Revenues Transfers from Trust Accounts 68,991.75 Refund of Wellesley College Grant 3,618.00 Other refunds 90.00

Total 72,699.75

Line 23 Restricted Funds (including restricted cash) Consolidated Account 1,539,185.00 Esselen Trust 457,991.00 Richards Trust Inc Acct 42,010.00 Norris Trust Inc Acct 12,566.00 Publications Trust Inc Acct 35,184.00 Hill Trust Inc Acct 8,208.00 Levins Award Fund 13,690.00 Brauner Memorial Trust 14,739.00

Total 2,123,573.00

202 ANNUAL REPORT Northeastern Section, ACS

PART IV

CHEMLUMINARY AWARDS

http://www.nesacs.org

203 PART IV - CHEMLUMINARY AWARDS

Award Category: Outstanding Performance by Local Sections

Contact Person: John L. Neumeyer Harvard Medical School / McLean Hospital 115 Mill Street Belmont, MA 02478-9106

Phone: 617-855-3388 Fax: 617-855-2519 e-mail: [email protected]

Description of Activity/Program:

The Northeastern Section provided an extremely rich program during 2003 for the general public and its large and varied membership: Students and faculty at educational institutions, employees of industrial and governmental facilities, retired and unemployed persons, younger chemists, and active researchers, administrators and teachers. The Section maintained its connection to legislative action, re-instituted a Speakers' Bureau, and worked to upgrade its website www.nesacs.org. It engaged in long-term planning, established a watchdog finance committee to oversee the flow of income and expenses on a regular basis, and provided monetary and honorific awards nationally and locally for research, chemistry in the public interest, teaching, and student achievement. Members of the Section, many of whom teach and do research at some of the nation's most important academic, industrial, and governmental institutions, fanned across the globe in 2003 to make presentations about their work in chemistry and education, representing NESACS and the Society to the whole world. Ten issues of the Section's newsmagazine, The Nucleus, with a total of 260 pages, were published in 2003.

At the same time, the Section was successful in emphasizing its human side to the membership and the public at large. Our National Chemistry Week events at Wellesley College and MIT reached out to over 1,000 students, their parents and their teachers, as well as members of the general public. The Membership and the Section Chair sent personal letters and a questionnaire to the almost 1,300 new members of the Section, inviting them to the monthly meetings and as its guest at the dinner that precedes the presentation by the invited speaker. Those expressing an interest in specific functions, such as government relations and hospitality, were directed to the chairs of those committees. The Chair wrote letters of congratulations to members who were honored and, sadly, letters of condolence to the families of those who passed away. Enthusiasm in the Section was evidenced by the high attendance at meetings of the Board of Directors and at the monthly meetings. The practice of holding 8-9 meetings of the Executive Committee during the year, which was begun three years ago, was continued in 2003 with very good effect; the experience and institutional memory of the past chairs provided invaluable guidance to the current officers.

· NESACS organized and sponsored a number of significant events during the year that we think were outstanding. The National Chemistry Week events, Earth's Atmosphere and Beyond, this year incorporated the Phyllis A. Brauner Memorial Lecture delivered by Dr. Bassam Shakhashiri. A symposium was also held later in the week at the Massachusetts Institute of Technology on the theme What's New in the Air? Atmospheric Chemistry in the 21st Century. · The exchange between the Younger Chemists Committee (YCC) and the Jungchemiker Forum of the German Chemical Society emphasized the international nature of research and education in the U.S.A. and Germany.

204 · Throughout the year, the events of the Education Committee, which continued to be extremely proactive, were very well attended with very enthusiastic high school and college students and their teachers. The Committee organized two student research conferences, the Connections to Chemistry workshop program for high school chemistry teachers, the Northeast Regional Undergraduate Day, and the education night meeting of the Section; it also gave awards to outstanding teachers and students, summer research scholarships, grants-in-aid for travel to the spring ACS National Meeting, and conducted the Section and National qualifying examinations for the Chemistry Olympiad. · During 2003, the Section presented the James Flack Norris Award in Physical Organic Chemistry to Dr. Ralph Bergman, University of California Berkeley, at the ACS National Meeting in New Orleans; the Gustavus J. Esselen Award to Dr. Bruce D. Roth for the discovery and development of Lipitor®. The award recognizes "a chemist whose scientific and technical work has contributed to the public well-being and has thereby communicated positive values of the chemical profession." The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry was also awarded to Dr. David N. Harpp of McGill University. The Henry A. Hill Award for Outstanding Service to the Northeastern Section was presented to Dr. Doris I. Lewis of Suffolk University.

To summarize, we can say that the year 2003 was successful in all respects. The Section was honored by receiving three ChemLuminary Awards at the National Meeting in New York City in September. The awards received were in the following categories: Committee on Local Sections: Outstanding Performance by a Local Section--Very Large Section; Committee on Minority Affairs: Outstanding ACS Scholars Program; and National Chemistry Week Task Force: Outstanding Event for the General Public Using the Yearly Theme. In addition, the Northeastern Section was named as an award finalist in the categories of National Chemistry Week Most Original Hands-On Activity or Chemical Demonstration and Outstanding Local Section Younger Chemists Committee Event.

We are proud of our accomplishments throughout the year and of all our members who worked so hard to accomplish our goals and to provide programs and activities of benefit to members of the Northeastern Section. We believe they merit recognition for their outstanding contributions.

Abstract:

The Northeastern Section is one of the largest and most active sections in the ACS with a most impressive list of universities, industries and research institutes matched nowhere else in the world. Due to the active participation of the membership of our Section and the work of our Board of Directors, we were again able to provide an extremely rich program during 2003 for the varied membership and the general public. Significant events included National Chemistry Week activities, the international exchange between YCC and the Jungchemiker Forum of the German Chemical Society, the presentation of awards nationally and locally for research in the public interest, teaching, service to the Northeastern Section, and student achievement. Our Education Committee continued to be proactive, organizing student research conferences, workshops for high school chemistry teachers and undergraduate students, and in the administration of the examination for the Chemistry Olympiad.

205 Pictures from the James Flack Norris Award Dinner November, 2003

Joseph A. Schwarcz - Introducer and former Norris Award Winner

Myron S. Simon - Archivist spoke on James Flack Norris

John L. Neumeyer NESACS Chair, 2003

David N. Harpp, Awardee McGill University Norris Award Winner 2003

David N. Harpp, Awardee John L. Neumeyer, NESACS Chair Frederick D. Greene, Chair of Norris Award Committee

Joel Haskell, Photographer

206 ACS Local Section Annual Report Part IV ChemLuminary Award Nominations

Award Category: Outstanding Local Section Younger Chemists Committee

Contact Person: Name: Lauren K. Wolf Address:Department of Chemistry Boston University 590 Commonwealth Ave. Boston, MA 02215 Phone: (617) 353-3241 Fax: (617) 353-6466 Email: [email protected]

Description of Activity/Program:

The Northeastern Section YCC (NSYCC) and its sponsored activities benefited from drastically improved organizational stability in 2003. The new NSYCC officers set forth the goal of becoming an organization that younger chemists in the region recognize and respect. We are working toward that goal by developing a more professional, organized structure. The NSYCC wants to become a stronger presence in the NESACS and represent the interests of younger chemists in the Northeast and beyond.

Because today's younger chemist is connected to the Internet and communicates most readily by e-mail, the NSYCC decided to network its members through a new website, www.nsycc.org. We worked very hard this year on a site that would truly represent the committee, its past and present accomplishments, and its future. The new site highlights all of the annual activities organized by the NSYCC, providing photos, schedules, and other detailed information from past programs. Younger chemists will be able to register for upcoming career fairs and submit abstracts for upcoming student research conferences through the website. The site also features a current news page where younger chemists can get updated information on monthly activities (such as the NESACS monthly meetings) and a “Sign-Up” for new members to be added to our mailing list ([email protected]). This NSYCC website is quite advanced compared to most local section sites; we are proud of it and feel it deserves some applause.

The NSYCC activities of 2003, the Annual Career Symposium, German Exchange Program, and Northeast Student Chemistry Research Conference, were all quite successful this year, attracting new members and participation from previously under-represented schools, such as Boston College and Tufts University. The Northeast Student Chemistry Research Conference (NSCRC) 2003 subcommittee also saw its largest, most diverse membership since the start of the conference in 1999. The conference itself, held on April 26, 2003 at Boston University, also boasted a large, diverse participation (approximately 80 attendees). For the first time, the NSYCC was able to award poster and oral presentations this year, giving winners free on-line journal subscriptions donated by the ACS. The annual career symposium, held February 14, 2003 at the Holiday Inn in Newton, MA, introduced younger chemists to non-traditional careers in chemistry. Speakers from areas such as patent law, sales, and Army food preservation inspired and informed younger chemists, encouraging them to attend the NESACS monthly meeting to further discuss employment issues. The German Exchange Program 2003 was perhaps, the most spectacular, well-organized, week-long exchange to date. Twelve undergraduate and graduate students from New Hampshire and Eastern Massachusetts traveled to Dresden and Munich, Germany, participating in networking events, a regional student research conference, and local industry tours. The program also boasts a true "success" this year; one of the NSYCC members that participated in the week's events applied for a post-doctoral fellowship, received it and will begin study in Germany in March 2004!

Abstract:

The Northeastern Section YCC (NSYCC) improved organization, installed new officers, and attracted new members in 2003. The NSYCC designed an innovative, professional website (www.nsycc.org), which provides its members with photographs and schedules from past programs, registration for new programs, and mailing list/membership

207 sign-up. In addition, the NSYCC held a career symposium featuring alternative careers in chemistry, sponsored a student research conference attracting presenters from schools in the Boston area and New Hampshire, and sent twelve undergraduate and graduate students to Germany for a week of science and networking.

208 ACS Local Section Annual Report Part IV ChemLuminary Award Nominations

Award Category: Outstanding Local Section Younger Chemists Committee Event

Contact Person: Name: Lauren K. Wolf Address: Department of Chemistry Boston University 590 Commonwealth Ave. Boston, MA 02215 Phone: (617)353-3241 Fax: (617)353-6466 Email: [email protected]

Description of Activity/Program:

The Northeastern region students who participated were selected based on their accomplishments in research, their interests, and a recommendation from their advisors. The steering committee, consisting of Dr. Amy Tapper, Dr. Michael Strem, Dr. Ruth Tanner, and Dr. Morton Hoffman, helped to coordinate the exchange and select the students. During the week, the students visited the Munich Technical University and viewed an impressive 900 MHz NMR, attended an International Career Symposium with featured speaker, Elsa Reichmanis, ACS President 2003, visited and toured facilities for silicon wafer production at Wacker-Chemie, and attended a regional student research conference, the Euregionale. Four of our students gave oral presentations at the Euregionale in Dresden. The remaining students presented posters. They represented the Northeastern Section well and were nominated in three of the four possible award categories at the conference.

A report was written by two of the participating students and was published in The Nucleus (the NESACS monthly newsletter) regarding the Exchange. The report began with a question: “Did you ever wonder where the triangular American Chemical Society logo originated?” The students go on to answer this question, displaying the knowledge gained during a visit to a replicate of Justus Liebig’s laboratory at the Deutsches Museum in Munich. “[The] five-bulb apparatus, [the Kaliaparrat] invented in 1831, allowed absorption of carbon dioxide generated by combustion. This, in turn, allowed the first determination of carbon in a sample by weight. One of the founding members of the ACS, J.L. Smith, studied with Liebig and suggested incorporation of the monumental Kaliapparat into the ACS logo we have today.” The students then detailed the week’s schedule (this can be viewed at German Exchange 2003 on the NSYCC website, www.nsycc.org) and concluded by saying, “What we’ve learned is that in many ways, the NESACS/YCC-GDCh/JCF exchange program can also be symbolized by the Kaliapparat. Our two societies have many common bonds and we still have much to learn from one another. The contacts we’ve made in Germany will last a lifetime. As we’ve learned from history, the

209 benefits of fostering this relationship between our societies can be vast. The exchange program can help make this all possible.”

Abstract:

During the week of February 23, 2003, twelve graduate and undergraduate students from the Northeast participated in the third annual exchange program between the Younger Chemist Committees of the Northeastern Section of the American Chemical Society (NESACS) and the German Chemical Society, Gesellschaft Deutscher Chemiker (GDCh). Students from universities in Massachusetts and New Hampshire were chosen based on their interests, research, and recommendations to participate in this year’s program, held in Munich and Dresden. The 2003 exchange offered students the opportunity to present research in an international forum, to learn about career possibilities in Germany and the United States, to explore foreign culture, and to make international contacts.

Photo:

210 ACS Local Section Annual Report Part IV ChemLuminary Award Nominations

Local Section: Northeastern Section of the American Chemical Society Award Category: Most Original Hands-on Activity or Chemical Demonstration Contact Person: Christine Jaworek Address: Emmanuel College 400 The Fenway Boston, MA 02115 Phone: (617) 264-7614 Fax: (781) 659-2231 E-mail: [email protected]

Description of the Activity: Name of the Activity/Program: UV Bead Activity1 Date Conducted: Sunday, October 19, 2003 Location of the Event: Wellesley College Number of Participants: Number of ACS members involved: 20 Number of volunteers: 60 Approximate size of audience reached: 400

For National Chemistry Week 2003, the Northeastern Section of the American Chemical Society and Wellesley College sponsored and co-hosted the kick-off event. Of the many hands-on activities and demonstrations available at the event, one that participants really enjoyed was entitled UV Bead Activity.

In this exploratory activity, participants first prepared a UV detector bracelet using a piece of rawhide and 10 UV sensitive beads (items readily available through www.teachersource.com). The participants were then sent outdoors to observe any changes in the beads. Upon returning indoors, participants were asked to share their experiences regarding their bracelets. During periods of cloudiness, the bracelets were placed in a black box and a UV light source was used to demonstrate the same concept.

The second part of this activity used pre-melted UV sensitive beads (baked in an oven for 10 minutes at 300 oF), sunscreens (same brand and different SPF factor or different brand same SPF factor), and Q-tips. A volunteer obtained three pre-melted beads; two were coated with sunscreens and the third was left as a control. The beads were placed on a piece of paper and carried outside. Alternatively, the beads were placed in a black box and a UV light source was used. Participants were asked to comment on the observations made during this portion of the experiment. Discussion then ensued regarding why one should wear sunscreens, what SPF means, and does brand of sunscreen matter.

Participants were allowed to take the bracelet home. Volunteers suggested that participants compare UV activity of the beads at different times of day. For this activity, there was an accompanying worksheet to complete, a take home sheet regarding purchase information for the beads, as well as a poster explaining the chemistry behind this activity.

This activity was successful in accomplishing the goals of National Chemistry Week. Educators who attended were impressed by this activity and were pleased with the accompanying information sheets, making this activity easily repeatable in the classroom, propagating chemistry enthusiasm.

1 Trupp, T. (2001) “Putting UV-Sensitive Beads to the Test,” J. Chem. Ed., Vol. 78, #5, p. 648A.

211 Abstract of the Activity: One activity enjoyed by participants at the National Chemistry Week Kick-Off Event sponsored and co- hosted by the Northeastern Section of the American Chemical Society and Wellesley College was the UV-bead activity (J. Chem. Ed, 2001, 78, 648A). In this activity, UV-sensitive bracelets were made using rawhide and UV-sensitive beads. Pre-melted beads were used to test the efficacy of sunscreens.

NCW 2003

Event: Kickoff Event for NCW Wellesley College October 19, 2003

Making a UV Detector

Individuals in Photo: Victoria Garbitt & Jennifer

212 ACS Local Section Annual Report Part IV ChemLuminary Award Nominations

Local Section: Northeastern Section of the American Chemical Society Award Category: Outstanding On-going NCW Event Contact Person: Christine Jaworek Address: Emmanuel College 400 The Fenway Boston, MA 02115 Phone: (617) 264-7614 Fax: (781) 659-2231 E-mail: [email protected]

Description of the Activity: Name of the Activity/Program: Phyllis A. Brauner Memorial Lecture Date Conducted: Sunday, October 19, 2003 Location of the Event: Wellesley College Number of Participants: Number of ACS members involved: 50 Approximate size of audience reached: 350

“The Phyllis A. Brauner Memorial Lecture honors the memory of Phyllis A. Brauner (1916-2000) and her steadfast dedication to the chemistry community and to teaching chemistry to the public.”2 Phyllis was an instructor of chemistry at Northeastern University as well as Swarthmore College; she was a professor of chemistry at Simmons College for 34 years. Actively involved in the Northeastern Section of the American Chemical Society, Phyllis was chair of the section in 1974, a Member of the Board of Directors, a Councilor of the section, a Trustee, and the Editor of the Nucleus.

“Over the years, Phyllis organized numerous lectures featuring chemistry educators, such as Hubert Alyea, Jerry Bell, and Dudley Herschbach. The lectures have always been free to the public and have drawn enthusiastic audiences of all ages.”3 In 1986, Phyllis played an integral role in starting a Holiday Lecture Series at the Museum of Science. Professor Bassam Shakhashiri presented the inaugural lecture on December 29, 1986.

“In commemoration of Phyllis’ lifetime of work the Northeastern Section of the ACS has instituted the annual Phyllis A. Brauner Memorial Lecture to be held during National Chemistry Week.”4 On November 4, 2001, the first memorial lecture was held at the Museum of Science in Boston. Professor Bassam Shakhashiri presented a lecture entitled Picasso, Da Vinci, Shakhashiri: Artistry and Chemistry. Approximately 400 individuals attended this free lecture.5 On October 20, 2002, Professor Bassam Shakhashiri regaled audiences at the Museum of Science-Boston with a Phyllis A. Brauner Memorial Lecture entitled “Quest for Chemistry: Moles, Molecules, and Mummies.” Once again, approximately 400 individuals attended this free lecture. The third memorial lecture was held on October 19, 2003 at Wellesley College; approximately 350 individuals attended the lecture-demonstrations performed by Professor Bassam Shakhashiri. Highlights of the lecture included: the methanol cannon and demonstrations of complete vs. incomplete combustion reactions. This lecture was the centerpiece of a day of hands-on activities featuring volunteers of all ages from retired chemists to student affiliates and

2 http://ase.tufts.edu/chemistry/iacobucci/brauner/phyllis.html (last accessed January 27, 2004) 3 http://ase.tufts.edu/chemistry/iacobucci/brauner.lecture.html (last accessed January 27, 2004) 4 http://ase.tufts.edu/chemistry/iacobucci/brauner/lecture.html (last accessed January 27, 2004) 5 Through the generous support of the Lowell Institute, these presentations were free.

213 involving participants from preschoolers through high school. This year’s event at Wellesley College featured the largest number of student affiliate chapters ever (6) to participate in a single NESACS NCW event, with approximately 50 SAACS students sharing the chemistry of the atmosphere with airplane experiments, tornados in a bottle, cloud formation, acid rain, and (others) while sporting the popular NCW tattoos. Volunteers were treated to an informal lunch with Dr. Shakhashiri in a brief break from the day’s whirlwind of activities. Approximately 350 individuals attended the lecture-demonstrations performed by Professor Bassam Shakhashiri. Highlights included: the methanol cannon and demonstrations of complete vs. incomplete combustion reactions.

For the last three years, the Northeastern Section of the American Chemical Society and either the Museum of Science or Wellesley College has co-sponsored these lectures. These popular lecture demonstrations have been performed to capacity filled lecture halls for the last three years. This event has become a highlight of the Northeastern Section’s National Chemistry Week Kick-off Event.

Abstract of the Activity:

The Phyllis A. Brauner Memorial Lectures honors the memory of Phyllis A. Brauner (1916-2000), a dedicated educator in and out of the classroom. For the last three years, the Brauner Memorial Lecture has been a part of the National Chemistry Week Kick-Off Event for the Northeastern Section of the American Chemical Society. Professor Bassam Shakhashiri has presented to capacity-filled lecture halls at each of these memorial lectures.

NCW 2003

Event: Phyllis A. Brauner Memorial Lecture Wellesley College October 19, 2003

Bassam Shakhashiri and his Fog Machine

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