PittCon 2004 Review presents our annual wrap-up of spectroscopic instruments that appeared this year at the Pittsburgh Conference.

n the long-standing Spectroscopy tradition, the editorial shoot” analyzers that produce results virtually anywhere. The units staff presents a sampling of 2004’s PittCon product incorporate a high resolution Si PiN diode detector that eliminates Idebuts. We have gathered brief information about as many radioactive isotopes. relevant products as could be squeezed onto these pages. As in years past, each company is listed above its product Jobin Yvon (www.jobinyvon.com) description, along with a Web address. While every effort has The AS-500 ICP OES autosampler incorporates USB communications been made to present as comprehensive a listing as possible, for additional flexibility, transfer rate, and capabilities for different this article cannot be considered a complete record of every applications. Standard options include a flow through rinse station. product shown at the conference. We hope you find this An extractable enclosure option is available for environments where roundup useful, and that you enjoy perusing it as noxious fumes and vapors are emitted. much as we enjoyed compiling it. Jordan Valley ATOMIC SPECTROSCOPY (www.jordanvalley-ar.com) The EX-Calibur is a liquid nitrogen-free Buck Scientific (www.bucksci.com) benchtop EDXRF with an The model 410-HG mercury analyzer uses integrated computer system. The 50-kV, a 400-mm quartz flow through cell to 50-W spectrometer is designed to provide achieve detection limits as low as 10 ppt high-count throughputs, and features BUCK SCIENTIFIC in clean laboratory environments. Its improvements in PIN diode technology, onboard computer allows users to pick peaks to determine peak resolution, and peak-to-background ratios. areas. Leeman Labs (www.leemanlabs.com) CETAC Technologies (www.cetac.com) Hydra AA mercury analyzers are designed to achieve 1-ppt detection The LSX-3000 Nexuss laser ablation system, for use with ICP and limits by employing EPA-compliant cold vapor atomic absorption ICP-MS, delivers the 193-nm using a solid-state Nd:YAG spectrometry (CVAAS). Features include a gas–liquid separator, con- laser, providing an alternative to commercial excimer systems. The tinuous flow-through rinse, online predictive maintenance, online LSX-3000 Nexuss also will output high energy 213- audio–visual help, WinHg software, and dual- nm and 266-nm , and allows fair com- beam detectors. parison between wavelengths. Niton LLC (www.niton.com) EDAX Inc. (www.edax.com) XLi and XLt XRF analyzers feature signal process- The Trident system combines x-ray microanalysis ing and detector technology for lab-quality ele- (EDS), electron (EBSD), and wavelength mental analysis of metal alloys, soils, minerals, dispersal spectrometry (WDS) in a single microanaly- paints, and other materials. They also offer simul- sis tool. The system’s hardware and software provide taneous analysis of as many as 25 elements by a all three tools with data sharing and combining, and variety of factory-programmed calibrations or by improve the speed and accuracy of data processing. user-programmable empirical calibrations.

Horiba (www.horiba.com), X-Ray Optical PANalytical (www.panalytical.com) Systems (www.xos.com) Axios WDXRF incorporate applica- The SINDIE is a monochromatic wavelength disper- tions and capabilities tailored for specific indus- sive x-ray fluorescence instrument that is designed PANALYTICAL tries. A new x-ray tube provides extra perform- for low sulfur measurements. The SINDIE has a lower limit of detec- ance, extended operating range, and stable tube output as high as tion of 0.4 ppm by weight, and its standard deviation at 1.0 ppm is 160 mA. A new version of analysis software incorporates an improved 0.1 ppm. user interface for sample handling, multiple languages, refinements in trace analysis, and compatibility with FDA reporting requirements. Innov-X Systems (www.innov-xsys.com) Portable x-ray fluorescence (XRF) analyzers provide fast and precise PerkinElmer (www.perkinelmer.com) elemental analysis of metal alloys. They are designed as “point and The HGA 900 graphite furnace is to be used with the company’s

18 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review

AAnalyst 400 atomic absorption spec- tems) is designed for high-speed, low-level troscopy instruments. The furnace is con- ICP-OES elemental determinations. The trolled by WinLab32 software and offers fea- instruments retain the dual-view capabilities tures for trace metal analysis, such as detec- of previous Optima systems, and feature the tion limits in the picogram range, low company’s solid-state RF power supply, microliter-level sample consumption, and which is designed to offer increased power freedom from interferences. Other features efficiency and new controlling firmware and include True Temperature Control and the software that adapts to challenging sample company’s AS 800 furnace autosampler. matrices. Comes with built-in spectrometer —The updated line of Optima Instruments dual-computer processors, which provide a (Optima 5100, 5200, 5300, and 2100 sys- continuous graphics mode, allowing users SPECTRO ANALYTICAL INSTRUMENTS to watch the ICP emission intensity in real time while modifying operation conditions, such as nebulizer flow and RF power.

Shimadzu Scientific Instruments (www.ssi.shimadzu.com) The AA-630 atomic absorption spectrometer is a flame model with an optional furnace accessory. It comes equipped with a Dynamic Beam Management System (DBMS), which is designed to ensure long- term baseline stability with low noise levels for precise analysis in routine to high-level research and development environments. The spectrometer includes dual detector and dual background systems, and burner heights and gas flow rates that are automat- ically set for each element and matrix.

SPECTRO Analytical Instruments (www.spectro.com) The SPECTRO Atlas handheld XRF analyzer is designed to provide users with quick on-site results, operating simplicity, and portability. Features include a rugged construction, and an ergonomic, lightweight (approximately 3.8 lb) design. The analyzer uses a single radioisotope x-ray source, ensuring that the measurement is virtually unaffected by interference from background radiation. —PHOENIX XRF spectrometers are designed for both qualitative and quantitative nonde- structive analysis of liquids, solids, powders, pastes, slurries, films, coatings, and many other materials. Optional features include tunable technology that permits optimum excitation of selected elements, data log- ging, and networking software.

MASS SPECTROMETRY

Advanced Development (www.acdlabs.com) Version 8.0 of ACD/MS Manager features enhanced generic component extraction techniques for finding individual compo-

Circle 17 www.spectroscopyonline.com PittCon Review nents, spectral correlation capabilities for worldwide regulatory requirements. The sys- ny’s ESI-TOF mass spectrometer, the data extraction of spectrally similar compo- tem also is suited for use in the clinical, microTOF. When equipped with Focus, the nents, and applicability for homologous foods, petrochemical, metals, pharmaceuti- microTOF mass spectrometer, which is series data analysis, metabolite, and impuri- cals, forensic, and geological industries. Its designed for use in drug development, ty extraction. Octopole Reaction System features metabonomics, and combichem analysis, redesigned ion optics and a high-transmis- can reportedly reach resolutions of 15k Agilent Technologies across essentially the entire mass (www.agilent.com) . The MSD Security ChemStation —The HCTplus ion-trap mass spec- software is a data system for trometer for identifying and charac- GC–MS that addresses all terizing proteins, peptides, and drug requirements for FDA 21 CFR metabolites is designed to offer high Part 11 for a closed system, sensitivity in full-scan MS and MS- and facilitates the compliant MS, as well as ultrahigh acquisition use of GC–MS in pharmaceuti- speed, optimal spectral information cal environments. The soft- content, and efficient in-scan ware is designed to offer dynamic range. The HCTplus fea- result versioning and version tures Compass software, and is management; user-independent, AGILENT TECHNOLOGIES reportedly four times more sensitive automatic audit trails; and electronic signing sion cell, which allows it to detect analytes than the company’s existing HCT mass spec- capabilities for electronic records. at parts-per-trillion levels even in samples trometer. ChemStation supports all Agilent 6890 with high levels of dissolved solids. series gas chromatographs and 5973 series Burle Electro-Optics (www.burle.com) mass-selective detectors. Bruker Daltonics Miniature time-of-flight detectors intended —The 7500ce ICP-MS system is designed for (www.bruker-biosciences.com) for portable detection trace metal analysis in environmental appli- Focus is a technology designed to signifi- devices offer a range of configurations and cations, and to meet strict U.S. EPA and cantly increase the resolution of the compa- high levels of mass resolution, dynamic

Circle 23 PittCon Review

range, and detection sensitivity. Thermo Electron Compact packages help make (www.thermo.com) portable instruments smaller and The Finnigan vMaldi ion source is lighter. An 8-mm flat input surface designed to be used with the provides uniform ion conversion Finnigan LTQ linear ion-trap mass gains in excess of 106. spectrometer for accelerated pro- teomics research. The integrated Dionex (www.dionex.com) system combines the speed of The LC Packings’ line of 5 cm x 100 MALDI with the sensitivity of the µm monolithic nano columns is Finnigan LTQ to create SEQUEST- designed for coupling with nano- searchable MS-MS spectra for electrospray MS and LC–MALDI sys- unambiguous protein assignments. tems. The columns offer typical flow rates of 500–800 nL/min, and allow Varian (www.varianinc.com) for the simultaneous separation of The MS Workstation 6.3 with 21 proteins and peptides. CFR Part 11 software tools allows BURLE INDUSTRIES customers using the 1200L LC–MS Hamilton Sundstrand Applied AccuTOF LC-TOF mass spectrometer and the system for pharmaceutical applications to Instrument Technologies dual ESI and Corona ESI ion sources. Delta comply with FDA’s regulations requiring (www.hs-ait.com) NMR software unifies NMR data acquisition access control, audit trails, and validation. Updates for the MGA1200 process mass and processing in a single application and is The new compliant MS Workstation 6.3 soft- spectrometers provide a variety of upgrade used on all JEOL ECA and ECX NMR spec- ware allows customers within this industry paths, including systems purchased from trometers. to document their activities using required PerkinElmer. Options include upgrading electronic signatures and record keeping. from ion pumps to turbomolecular pumps, LECO Corp. (www.leco.com) which is The LC–TOF MS-MS system for complex liq- Waters (www.waters.com) uid sample analysis is a eLab Notebook software digitally captures benchtop instrument and stores scientific data of all types, includ- designed to offer acquisition ing mass spectra, chemical structures, rates of 100 spectra/s across graphs, tables, and texts. The software is a wide range to provide the designed for scientists who keep paper data density required for sup- notebooks, and can be used by multination- porting fast separation tech- al organizations and their IT professionals. niques. MOLECULAR SPECTROSCOPY MassTech (www.apmaldi.com) Analytical Spectral Devices The AP/MALDI-411 ionization (www.asdi.com) THERMO ELECTRON CORP. source is designed to interface QualitySpec Pro is a benchtop, fast-scanning with Waters/Micromass Z-spray. The NIR analyzer. Small, lighweight, and trans- designed to increase reliability by eliminat- source includes: ion source head for 96- portable, it is designed for nondestructive ing ion pump spiking, installing new spot sample plate, two 96-spot sample Windows®-based software, or the complete plates, laser control unit, elec- rebuilding of a model 1200 into a model trical and optical cables, CCD 1200EC. camera, LCD monitor, and con- trol software. IonSpec (www.ionspec.com) The QFT-7 Hybrid Fourier-transform mass Shimadzu Scientific spectrometer is a "triple quadrupole" FTMS Instruments with a dual orthagonal source. This hybrid (www.ssi.shimadzu.com) FTMS instrument has the features of the tra- LCMSsolution 3.0 software is ditional triple quad plus features and disso- part of the Lab Solutions network,

ciation techniques (IRMPD, ECD, CID) of an and offers diverse data handling, inte- ANDOR TECHNOLOGY FTMS. gration with regulatory compliance require- ments, and custom reports in both stand- materials analysis and QA/QC, and features JEOL (www.jeol.com) alone and network environments. a variety of spectral ranges for use in a wide Open Access Software is used for the variety of applications.

24 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review

Andor Technology ment, survey, and in-line monitoring appli- B&W Tek, Inc. (www.bwtek.com) (www.andor-tech.com) cations. The probes are best used with clear, The BRM-785 nm Cleanlaze Series lasers are The Mechelle spectrograph is available in a free-flowing liquids because optical radia- narrow spectral linewidth lasers designed range of resolutions and is based upon the tion makes two passes through the same for applications. The Echelle grating principle. Its optical design probe gaps to minimize diameter. lasers are based upon amplification gives low crosstalk and equally spaced order and narrowing technology, are powered by separation, providing for a wavelength range Axsun Technologies (www.axsun.com) a 5-V dc input with low-power consump- from the deep UV to the NIR, with full spec- The NIR-APS (application prototyping sys- tion, and provide a TTL modulation port, tral continuity and no overlapping wave- which can accept a modulation con- lengths. trol input of as high as 100 kHz.

Axiom Analytical Bio-Rad Laboratories (www.goaxiom.com) Informatics Division The FDR-790 diffuse reflectance probes (www.informatics.bio-rad.com) are configured for operation in remote KnowItAll version 4.0 provides users processing applications, and are designed BRUKER OPTICS of the KnowItAll Academic Edition to approach the theoretical maximum possi- with on-demand access to additional soft- ble signal level when coupled to a spec- tem) analyzer is designed for the exacting ware options. Through the software, users trometer by means of a pair of single 600- demand and hostile environments of can activate additional options within µm core optical fibers. Additional features process applications. Based upon the com- KnowItAll, such as IUPAC NameIt for IUPAC include remote operation, compatibility with pany’s MEMS tunable optical filter, micro- naming and Model IT HNMR for advanced efficient multiplexing, and extended lengths. optics, and LIGA micro-alignment structures, proton NMR spectrum predictions. —FPX transmission probes, intended for use along with a broadband SLED light source in the near-infrared and visible regions, pro- and wavelength reference, the miniature BioTools (www.btools.com) vide the benefits of high performance spec- analyzer is designed to enable true process The Chiralir molecule analyzer is based troscopic analysis in the small diameters analytical spectroscopy in industrial manu- upon vibrational (VCD) required for small-scale reaction develop- facturing settings. spectroscopy. Featuring a Bomem compact

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optical bench with a ZnSe beamsplitter and supply, voltage divider, and signal amplifier lenses, the unit is calibrated internally and in a durable housing. Each module is optically aligned for routine operations, has designed to offer low power consumption a useable spectral range of 800–1800 cm-1, (10 mA at 12 V) and minimal high-voltage and a BaF2 wire grid polarizer. Additional supply interference. The product line con- features include Bomem GRAMS-32 soft- sists of nine distinct modules, which oper- ware and Chiralir Windows®-based software. ate in the 300–660 nm and 300–800 nm —The ChiralRAMAN is a Raman optical activ- wavelength ranges. ity (ROA) spectrometer featuring fiber-optic light collection, holographic transmission Cal Sensors (www.calsensors.com) grating, CCD detection components, and A PbSe 256-element array, TEC, tempera- real-time optical artifact elimination. ture sensor, and multiplexer are assembled Software components include automatic in a low-profile package accompanied by a optimization of exposure patterns to mini- USB controller board that includes soft- mize acquisition and illumination time, and ware. Specifically designed for spec- fully automated ROA-spectra acquisition troscopy applications in the 1–5.5 µm using predefined standard conditions. region, the array has high aspect ratio pix- els on 50-µm centers.

Carl Zeiss (www.zeiss.de) The MCS 621 VIS spectrometer can measure in the UV, VIS, and NIR ranges (195–2150 nm). Modular construction allows the inte- gration of several spectrometer slots into one housing and enables one instrument to cover a wide measurement range using vari- ous spectral ranges. , noise, and BURLE INDUSTRIES linearity of the polychromators are based upon previous polychromators and the new Bruker Optics (www.brukeroptics.com) MCS CCD and PGS 1.7 units. The Vertex 70 FT-IR spectrometer features the Bruker Artificial Intelligence Network (BRAIN), Control Development Automatic Optical Component Recognition (www.controldevelopment.com) (ACR), a plug-and-play Ethernet connection, Dryer Monitors for pharmaceutical manufac- and Automatic Accessory Recognition (AAR). turing consist of an NIR spectrometer, a It provides data acquisition based upon 24- sampling head, a computer, and software. bit dynamic range analog-to-digital convert- The unit’s spectrometer is based upon 256- ers, which are integrated into the detector’s element, T.E. cooled InGaAs arrays with a preamplifier electronics. wavelength range of 900–1700 nm. The —The TPI spectra1000 turnkey Terahertz monitor is battery-operated, and has wire- spectrometer system encompasses frequen- less communications, 802.11g, making it cies from 100 GHz to approximately 3 THz. networkable and accessible from anywhere The pulsed time domain THz spectrometer in the plant. is designed to complement the company’s —The Blend Uniformity Monitor for pharma- line of FT-IR spectrometers, such as the IFS ceutical manufacturing consists of an NIR 66v/S and the IFS 125 HR. spectrometer, a sampling head, a computer, and software. The unit’s spectrometer is BURLE Industries, Inc. based upon 128-, 256-, or 512-element (www.burle.com) InGaAs arrays, which are cooled or tempera- BURLE’s Photosensor Module line is ture stabilized. The monitor is battery-oper- designed for a wide range of applications, ated and has wireless communications, including fluorescence spectroscopy in 802.11g, making it networkable and accessi- molecular biology, semiconductor wafer ble from anywhere in the plant. inspection, and low-light measurement detection activities. The new line consists of Digilab (www.digilabglobal.com) 1.125-in. diameter end window-type mod- The SpotCheck Near-IR portable spectrome- ules, which package a high-voltage power ter is a compact molecular detection system

Circle 29 www.spectroscopyonline.com PittCon Review

News From PittCon 2004: • According to the conference’s organizers, PittCon 2004 drew 25,025 total attendees for the entire event, an increase of nearly 11% from 2003, and the first increase after four years of decline. There were 1195 exhibiting companies in 2714 booths, a decline from last year’s totals of 1260 companies in 2856 booths). In addition to attending the exposition, the conferees listened to 1200 oral presentations, viewed more than 900 posters, checked out 50 seminar rooms, or attended one of 240 short courses. • This year’s theme was “Solutions for Better Chemistry.” The technical program featured major focus areas on bioanalytical chemistry, pharmaceutical chemistry, nanotechnology, environmental chemistry, forensic analysis, life science tech- nologies, food analysis, applied molecular spectroscopy, mass spectrometry and chemical separations. A number of prestigious awards were presented, and the 2002 Nobel Laureates in Chemistry, Koichi Tanaka of Shimadzu Corporation and Kurt Wuthrich of the Swiss Federal Institute of Technology, each presented special lectures. • Larry Faulkner, president of the University of Texas, presented the plenary lec- ture on the topic of “Good Chemical Measurements and Good Public Policies.” He addressed four key areas: the impact of on public debate

HARRICK SCIENTIFIC and public policy; how chemical information is handled and understood in pub- lic debates; areas of analytical chemistry that will be critical to sound public poli- designed for material identification and cy in the future; and implications for the education of both our leaders and the quality control applications. The instrument general public. is based upon an acousto-optic tunable fil- • On the heels of the February announcement that it had joined Teledyne ter, is about the size and weight of a video Instruments to form a new analytical instrument company, Teledyne Instruments camera, and is operated via a PC through a Leeman Labs and Hitachi High-Technologies, a division of Hitachi, announced USB connection. Typical applications include the formation of a spectroscopy partnership. The first line of instruments liquid fuel analysis, pharmaceutical analysis, stemming from the announcement — the Z2000 series of Zeeman atomic and gas monitoring. absorption spectrometers — were on display at the conference and included: —The Synergy QA/QC dispersive Raman Z-2000 Zeeman flame/furnace tandem atomic absorption spectrometer versions; spectrometer is designed to provide a reso- Z-2390 Zeeman flame atomic absorption spectrometers; and Z-2700 Zeeman lution of better than 8 cm-1, and to cover graphite furnace atomic absorption spectrometers. the 2000–200 cm-1 spectral range. • A merger was announced between Wilks Enterprise, Inc. and Optical Coating Applications include incoming material iden- Corporation (OCC). The partnership will be known as Wilks Enterprises, Inc., and tification, quantitative analysis of intermedi- combines the Wilks Analytical division, which manufactures infrared filter-based ates and final products, and the analysis of analytical instruments, with OCC’s experience in the design and manufacture of hazardous materials. custom optical filter and windows. Enwave Optronics (www.enwaveopt.com) bilities for sampling small, hard, corrosive, The portable HRC-10 Raman analyzer is well or irregularly shaped samples. Features suited for condensed material identification include a horizontal sampling surface with and process control. The compact and fully an active sampling diameter of less than integrated system features a high power 500 µm on its monolithic diamond crystal. NIR frequency-stabilized, narrow linewidth Typical applications include the routine diode laser, a high Raleigh rejection– analysis of samples as small as a single fiber throughput fiber optic probe, and a CCD- or bead, as well as analyses involving based high resolution/throughput spectro- extremely hard samples, abrasive powders, graph. corrosive metals, liquids, solids, and pastes.

Harrick Scientific (www.harricksci.com) INPHOTONICS/REMSPEC InPhotonics (www.inphotonics.com) The GATR grazing angle ATR accessory is crystal. The accessory reportedly provides at The VERAX Raman spectrometer offers 4 designed for the analysis of monolayers on least an order of magnitude increase in sen- cm-1 resolution and 250–1800 cm-1 range. semiconductors and metallic substrates. The sitivity to grazing angle methods. With a standard RamanProbe, the VERAX is instrument features a specially designed —The Video Meridian combines the compa- a versatile laboratory system for routine pressure applicator, which offers good con- ny’s Meridian diamond micro-ATR accessory analysis and basic research. With an indus- tact between the sample and the Ge ATR with video imaging and force sensing capa- trial probe and specialized software, the sys-

30 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review tem enables real-time reaction monitoring to offer effective, cost-efficient perform- less than 2% peak-to-peak. for process development. ance, while the FT/IR-6100, FT/IR-6200, and FT/IR-6300 models are designed for a MIDAC Corp. (www.midac.com) InPhotonics (www.inphotonics.com), wide range of critical research and devel- The Titan-OL gas analyzer provides real- Remspec (www.remspec.com) opment applications. time, multicomponent extractive gas analy- Remspec’s ReactionView fiber-optic FT-IR —The J-810 Chiro-optical spectrometer sis for online and multipoint analysis. The spectrometer system and InPhotonics’ measures circular dichroism; chiro-optical systems are packaged in NEMA enclosures VERAX fiber-optic Raman spectrometer can phenomena, such as linear dichroism; and contain a high-resolution FT-IR spec- be controlled simultaneously via Remspec’s optical, rotary ; fluorescence- trometer, gas cell, and sample manifold. RamIR reaction-monitoring system, which detected circular dichroism; and magnetic Standard manifold configurations include enables monitoring in real time with 3D circular dichroism. purge, calibration lines, and as many as 10 views of both sets of spectra, to form a sample sources. The Titan-OL system and dual FT-IR and Raman reaction moni- Kaiser Optical Systems software can accommodate additional sam- toring system. ple lines far in excess of the standard 10. International Crystal Laboratories (www. Newport Corp. internationalcrystal.net) (www.newport.com) NIST-traceable calibration OSM optical spectrometers pro- films for FT-IR spectrome- vide spectrometric analysis in a ters are available in the small footprint. The instruments 38-µm pathlength that are operated easily in a stand- matches the NIST stan- alone mode or via computer dard, and also in sets of control. The spectrometer’s two pathlengths, which optics are optimized to achieve when used, enable more stray-light levels in the hundredth- precise calibration of FT-IR of-a-percent, subnanometer resolu- instruments. The standards tion, and designed-in cooled detectors are available as freestand- for the NIR versions. ing films, and also can be deposited on KBr windows to MIDAC CORP. Ocean Optics eliminate fringing. (www.oceanoptics.com) The HR4000-UV-NIR is a high-resolution, Jasco (www.jascoinc.com) (www.kosi.com) miniature fiber-optic spectrometer for multi- The NRS-3000 Series of benchtop, singly The RamanRxn3 analyzer is a self-contained, wavelength analysis over a broad 200–1100 dispersive micro-Raman spectrometers are multichannel-capable Raman system nm range with 0.5-nm resolution. Features available in three models and feature PC- designed for use in classified hazardous include software-controlled triggering and controlled optical systems that are designed plant environments. The analyzer incorpo- timing functions, programmable digital and to maximize optical throughput while elimi- rates a long-life 785-nm laser and advanced analog outputs for higher application level nating the need for daily adjustments or detector technologies. Fiber-optic coupling and accessory integration, and USB 2.0 laser realignments. The instruments feature with either process probes or noncontact technology. a color CCD sample viewing system with optics enables real-time, in situ analysis of image-capture capability, with optical binoc- sample volumes ranging from 5 mL to 5000 PerkinElmer (www.perkinelmer.com) ular or trinocular viewing systems also gal. This unit is suitable for process develop- The Spectrum Spotlight 350 FT-NIR imaging available. Features include direct Raman ment in either the laboratory or the pilot system provides pharmaceutical develop- imaging and software switched optics for as plant, and for manufacturing within the ment organizations with information about many as six lasers. chemical, polymer, and pharmaceutical microscale chemical variations. The system —The FT/IR-4000 and FT/IR-6000 series industries. is designed to provide faster problem solv- spectrometers are based upon a highly sta- ing, shorter time-to-market for new formula- ble corner-cube interferometer, and feature Melles Griot (www.mellesgriot.com) tions, and reduced rework costs. an auto-alignment option, which is The 85 BCA series of diode-pumped solid- designed to ensure optimal instrument state single-frequency lasers is designed for PIKE Technologies (www.piketech.com) performance after changing optical compo- OEM applications in high-resolution Raman The Dual Variable VeeMAX II specular nents, and the Baseplate Purge System, spectroscopy. Designed to operate in the reflectance accessory is designed with inde- which is designed to ensure greater sensi- blue spectral region at 473 nm, the lasers pendent selection of angle of incidence and tivity across all spectral ranges. The FT/IR- feature a single longitudinal mode, angle of collection. Both angles are inde- 4100 and FT/IR-4200 models are designed enhanced beam quality, and output noise of pendently variable from 20° to 80°. Typical

32 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review

Roper Scientific Ultrasonic Scientific (www.roperscientific.com) (www.ultrasonic-scientific.com) The Spec-10 XTE CCD spectroscopy system The Kinetic Analyzer is a high-reso- is capable of being cooled to –100 °C with- lution spectrometer for titration measure- out any liquid assistance (no water or liquid ments and for analyzing kinetics of chemical nitrogen). The XTE systems come in eight reactions in small volumes (~40 µL). models, including either front- or back-illu- minated models, models with 1340 x 100- pixel or 1340 x 400-pixel CCDs, and models with or without deep-depletion technology. —The OMA V series of InGaAs detection sys- tems utilize 1024-element linear photodi- ode arrays designed to offer NIR sensitivity from 1.0 to 2.2 µm. Features include a spec- tral data rate of 900 spectra/s and cyrogenic cooling to temperatures as low as –140 °C. PIKE TECHNOLOGIES applications include the study of surface fin- Shimadzu Scientific Instruments SHIMADZU SCIENTIFIC INSTRUMENTS ishes and coatings. (www.ssi.shimadzu.com) Microstructural and molecular processes can —Three reflection crystal plates for the The SolidSpec-3700 Series UV-Vis-NIR spec- be measured when of select- MIRacle ATR accessory are available in dia- trophotometers are available in two models, ed compounds are changed (titration). mond and ZnSe, and as upgrades to exist- the SolidSpec 3700 for standard applica- ing MIRacle accessories. They are designed tions, and the 3700DUV for deep UV meas- Wilks Enterprise (www.wilksir.com) to provide a threefold increase in sample urements to 165 nm. Both models are InfraRan Specific Vapor Analyzers can meas- response, and can be used for applications equipped with three detectors, including a ure as many as four specific gases. The involving minor components in liquid or photomultiplier tube for the UV-Vis region, portable mid-IR gas analyzers weigh less and InGaAs and PbS detectors for the NIR than 18 lb and are well suited for on-site region. The instrument’s measurement survey measurements. An internal recharge- range varies from 165 to 3300 nm depend- able battery provides as much as 8 h of ing upon the application, the use of an inte- continuous field use. Typical applications grating sphere, and the optional direct include OSHA compliance testing, fume detection unit. hood evaluation, indoor air quality studies, hospital anesthetic gases, and specific gas Thermo Electron Corp. monitoring. (www.thermo.com) —The Wilks CO2 In-Line Sensor utilizes The Nicolet series of FT-IR spectrometers are infrared absorption as the measuring tech- used for routine analysis as well as nique and operates from 0 to 5 volumes with advanced research. An ETC IR source JASCO, INC. provides a stabilized signal that adds solid samples. longer source lifetime and enables —Transmission sampling plates for the com- analysis of otherwise intractable IR sam- pany’s Microliter Plate accessory utilize a ples. Gold-coated optics and a specially bonded polymer mask to define redesigned optical layout provide greater the sample area, providing an easily signal throughput. External experiment cleansed surface during sample exchange. options add capabilities for IR Typical applications involve microchemistry and imaging, FT-Raman, GC- METTLER TOLEDO formulation, and biotechnology research. IR, modulation, thermogravi- metric analysis, and other techniques and a precision of 0.02 volumes or 0 to 1000 Renishaw (www.renishaw.com) analyses. mg/100 mL, 4 mg/100 mL. There are no RA100 Raman analyzers are compact, trans- —The Nicolet Continuµm XL is a research- moving parts, filters, or permeable portable, high efficiency spectrometers that grade FT-IR featuring an optical diaphragms. can be equipped with one or more fiber- design that enables users to perform single- optic probes for remote analysis. They are point collection and imaging on the same GENERAL ideally suited to industrial process monitor- system. In single-point mode, dual remote ing, and other applications where the sam- sample masking provides optimum spatial Advanced Chemistry Development ple cannot be brought to the spectrometer. resolution. In imaging mode, high fidelity (www.acdlabs.com) optics allow rapid collection of sharp images. Version 8.0 of the ACD/UV-IR Manager soft-

34 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review ware uses the SIMPLISMA (SIMPLe-to-use- spectra archived using 2-cm-1 data resolu- Interactive Self-modeling Mixture Analysis) tion and 16-bit ordinate precision, and a fre- algorithm, a multivariate curve resolution quency range of 650–4000 cm-1. technique that resolves mixture data into pure component spectra and concentration FOSS (www.foss.dk) profiles without prior knowledge of the mix- Purgeable probes for NIR measurements of ture’s components. powders and other reflecting materials during —ACD/Curve Manager version 8.0 is processing are designed to solve sampling designed to deliver enhanced support for interface problems caused by sample buildup on the probe tip and can be inserted and retracted auto- matically through a process JASCO, INC. flange as required. When retracted, the probes facilitate plates. Spectra Manager CFR is designed for the cleaning of the probe shaft. 21 CFR Part 11 compliance and features security-enhanced software with data track- Inorganic Ventures ing and audit capabilities. (www.ivstandards.com) —The SFC chiral analysis system is optimized Premium off-the-shelf and for high-sensitivity analysis of chiral com- customized multielement stan- pounds. The system’s circular dichroism dards are available for EPA, detector simultaneously can determine both QC, calibration, and custom circular dichroism and UV absorption of the analyses. A 12-part Certificate sample in the same cell for the direct deter- of Analysis accompanies each mination of optical purity. THERMO ELECTRON CORP. standard, which features assay the management of data, including hyphen- information that details every element with Melles Griot (www.mellesgriot.com) ated techniques that currently are not man- traceability to specific NIST standard refer- The 85 YCA series of diode-pumped, solid- aged by ACD/SpecManager or ence materials, including number and lot. state lasers (DPSS) operate at 561 nm and ACD/ChromManager applications. Features are designed to produce single-frequency include the ability to directly import x-ray Jasco (www.jascoinc.com) output with less than 3% peak-to-peak powder diffraction data files in Bruker DIF- The Spectra Manager II vendor-specific, noise. The lasers are available with output FRAC-AT, Bruker DIFFRAC-PLUS, and cross-platform spectroscopy software pack- powers as high as 10 mW, have an M2 factor PANalytical instrument formats. The module of less than 1.2, and a nearly circular (<1.1:1 contains a universal viewer for hyphenated aspect ratio), linearly polarized beam. Typical data, and comes equipped with the built-in applications include confocal laser scanning ACD/ChemSketch drawing package. microscopy, ROX, and Alexa Fluor. —ACD/Automation Server provides auto- —The 56 ICS series of high-power, violet, mated data collection, processing, and diode laser systems are designed with out- database population throughout the puts of either 408 nm or 440 nm, with enterprise using ACD/Labs tools power as high as 24 mW at 408 nm and user-written programs. The and 3.5 mW at 440 nm. The systems utility comprises two subsystems that are CE and CDRH certified, fully self- communicate with each other to produce an contained, and require 8 V dc to oper- intelligent data control package, and initiates ate. They are available with elliptical macro-driven data processing through (1.0 x 2.8 mm) or circular (1.0 mm and 3.0 ACD/SpecManager SQL, and other ACD/Labs mm) beams and can be modulated at rates software modules that facilitate macro design. as high as 5 MHz.

Aldrich/SensIR Technologies WILKS ENTERPRISE Mettler Toledo (www.mt.com/us) (www.sigmaaldrich.com) LabX Balance, the latest addition to the (www.sensir.com) age for controlling a complete range of LabX software platform, is designed to help The Aldrich/SensIR Technologies ATR-IR CD- spectroscopic instrumentation, including FT- users achieve higher levels of quality man- ROM Library features high-resolution spectra IR, UV-Vis-NIR, Fluorescence, Raman, and agement and regulatory compliance. The for use with Thermo Electron SpecID spec- CD, features enhanced audit trails, an opti- software package replaces traditional, tral search software. It contains 18,000 pure mized FT-IR instrument interface, stream- paper-based weighing processes with its compounds of the most common chemical lined user interaction for instrument control, secure networked data system, and elimi- compounds found in the Aldrich handbook, and enhancements to Canvas report tem- nates the need for subsequent manual tran-

36 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review scription into a LIMS or other systems. PittCon Editors’ Awards —The Refracto 30GS is a compact, digital On the exhibition floor, one means of identifying innovation highlights from refractometer for laboratory and production the sea of new product introductions is the annual PittCon Editors’ Awards. environment measurements. Designed with This years’ informal poll of editors attracted 22 nominations proposed by 11 a sapphire prism held by a ring of industrial editors from various publications, and produced one of the closest results in hard gold-plated brass, the portable analyz- recent years, with few votes separating the winners of the Gold, Silver and er can be used as a benchtop instrument, Bronze awards. store as many as 1100 results, including In a tie for the first place, the Gold Award was presented jointly to Bruker sample identifications, measurement units, Optics, Inc. (Billerica, MA) for the TPI spectra 1000, the first commercially avail- date, and time, and display results in more able pulsed-time domain terahertz spectrometer, and Waters Corp. (Milford, MA) than 15 measurement units. for its ACQUITY Ultra Performance Liquid platform. —Stare version 8.1 is new Thermal Analysis Wyatt Technology Corp. (Santa Barbara, CA) picked up the Silver Award for its (TA) software designed to support all Optilab rEX extended range refractive index detector. The company says the Mettler Toledo TA hardware enhancements, instrument has “256 times the detection power and up to 50 times the dynamic including the new DSC sensor. The software range of every other RI detector in existence today.” works in a Windows® XP operating environ- Still only a few votes behind the Gold and Silver winners, Axsun Technologies, ment, has Ethernet capabilities, and offers Inc. (Billerica, MA), making its first appearance at PittCon, received the Bronze the ability for multiuser multitasking. Award for its NIR-APS Analyzers. The optical platform at the heart of these fully-integrated analyzers, that are not much larger than a pack of playing cards, Ocean Optics (www.oceanoptics.com) represents a breakthrough in miniaturized NIR spectroscopy, according to The FOXY-LITE handheld oxygen sensor uses the company. time-resolved fluorometry and sol-gel based Other nominations, in alphabetical order: Agilent Technologies Inc. (Palo Alto, optical sensing technology to calculate oxy- CA), orthogonal nanospray ion source; Brookhaven Instruments (Holtsville, NY), gen concentration in a sample with a BI-MwA molecular weight analyzer; ChromBA (State College, PA), fractionating response time of less than 1 s. The instru- columns for HPLC; Control Development Inc. (South Blend, IN), blend uniformity ment includes a 1000-µm stainless steel monitor and dryer monitor; Dionex Corp. (Sunnyvale, CA), APS-2000 series oxygen sensor probe with a transducer autopurification system; Giffin Analytical Technologies Inc. (West Lafayette, IN), material consisting of a fluorescent rutheni- Minotaur 300 cylindrical ion trap MS; Haber Inc. (Bayonne, NJ), EMP 15 D/A um complex immobilized in a submicrome- electromolecular propulsion instrument; Mettler Toledo (Greifensee, ter-thin gel-sol matrix. Switzerland), DSC 822e with high-sensitivity (HSS7) sensor; Nanostream Inc. (Pasadena, CA), Veloce/Brio micro-parallel HPLC system; QuantomiX Inc. PerkinElmer (www.perkinelmer.com) (Weizmann Science Park, Israel), QX capsule for wet sample SEM; SLS Micro Pyris version 7.0 thermal analysis software is Technology (Hamburg, Germany), GCM 5000 micro GC; Thermo Electron Corp designed to be used in materials and phar- (Waltham, MA), LTQ LC–MS linear ion trap; and Varian Inc. (Palo Alto, CA), CP- maceutical labs. Capabilities include a real- 4900 DMD micro GC and the 4000 ion trap GC–MS. time reference curve and calculations fea- tures, which allow users to compare a cur- rent measurement against a reference curve enhanced sensitivity and new insights into during data collection, and have the soft- materials processes that cannot be obtained ware execute real-time calculations during from traditional thermal analysis methods. sample runs. MultiCurve, another new fea- ture, allows users to save a view of several Scivex, Upchurch Scientific Division different data files in one single file for quick (www.scivex.com) reference. Software is available with 21 CFR Confluent nano fluidic modules are Part 11–compliant tools, such as user-level designed to offer isocratic fluid delivery at management, file protection, and audit trails. flow rates as low as 20 nL/min, and as —LABWORKS Enhanced Security LIMS soft- high as 4.5 µL/min. The modules use a ware schedules sample tests and collects, specially designed pump coupled with controls, documents, and disseminates Nanopeak switching valves, and inline, information from lab instruments for deci- noninvasive flow sensors to form a com- sion-making processes. Features include a plete fluid delivery system. The unit allows broad international language capability. for the connection of 1/32 in. o.d. tubing, —The HyperDSC is a thermal analysis with the option of adding even smaller method for the characterization of materials, tubing through the use of PTFE FEP tubing such as plastics, available exclusively on the sleeves, and has a maximum pressure rat- company’s Diamond differential scanning ing of 5000 psi. THERMO ELECTRON CORP. calorimeter. It is designed to provide

38 Spectroscopy 19(5) May 2004 www.spectroscopyonline.com PittCon Review

SCP SCIENCE (www.scpscience.com) validation and regulatory compliance. The sensors, gauges, bar-code scanners, meters, A new bench-top fume hood for digestion Symbion Language is tailored specifically to and other instruments. The latest version systems is built for durability and easy provide a standard set of commands for the includes upgraded TCP-Com software. access to samples. Replacement air is control of all aspects of an analytical system. drawn through dual HEPA filter inlets Tienta Sciences (www.jyhoriba.com) offering cleaner ambient air. An optional TALtech Inc. (www.taltech.com) As Tienta Sciences’ first product offering, blower unit removes all fumes into a labo- The latest version of the WinWedge 32 Pro SpectRIM, available through Jobin Yvon, is a ratory fumehood and exhausts it out of Software collects RS232 data from any labo- standardized, mass-produced substrate that the building. ratory instrument or device directly into Excel, can facilitate Raman, reflectance IR spec- —The DigiPREP HT digestion block system’s Access, LIMS, and other Windows® applica- troscopy, mass spectrometry, and reflectance heating system can reach temperatures as high tions. Typical applications include collecting light microscopy on the same sample. as 450 °C and has a built-in reflux zone real-time data from balances, pH meters, designed for faster digestions. Varian, Inc. Available in 40-tube (100-mL) and (www.varianinc.com) 20-tube (250-mL) models, the sys- Diffuse reflectance accessories tem is CE/UL/CSA approved and (DRAs) complement the 4000- comes with either a key pad or a 6000i series spectrophotometers. touch screen controller. The new DRAs are available as internal or external components Symbion Systems and come in three different mod- (www.goaxiom.com) els designed to extend the flexibil- The Symbion-DX process analysis ity of specific base instruments. software suite controls every aspect DRAs employ an integrating of an analysis, including sample sys- sphere and a highly reflective tem design and control, data acquisi- internal coating material to detect tion, multivariate analysis, trend plot- the transmission and reflection of ting, data archiving, performance SCP SCIENCE radiation from a sample. ■

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