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Les Vaccins : Pourquoi Font-Ils Peur ? Nelly Gallino, Lucie Le Pennec

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Les Vaccins : Pourquoi Font-Ils Peur ? Nelly Gallino, Lucie Le Pennec Les vaccins : pourquoi font-ils peur ? Nelly Gallino, Lucie Le Pennec To cite this version: Nelly Gallino, Lucie Le Pennec. Les vaccins : pourquoi font-ils peur ?. Sciences pharmaceutiques. 2018. dumas-01762521 HAL Id: dumas-01762521 https://dumas.ccsd.cnrs.fr/dumas-01762521 Submitted on 10 Apr 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. AVERTISSEMENT Ce document est le fruit d'un long travail approuvé par le jury de soutenance et mis à disposition de l'ensemble de la communauté universitaire élargie. Il n’a pas été réévalué depuis la date de soutenance. Il est soumis à la propriété intellectuelle de l'auteur. Ceci implique une obligation de citation et de référencement lors de l’utilisation de ce document. D’autre part, toute contrefaçon, plagiat, reproduction illicite encourt une poursuite pénale. Contact au SID de Grenoble : [email protected] LIENS LIENS Code de la Propriété Intellectuelle. articles L 122. 4 Code de la Propriété Intellectuelle. articles L 335.2- L 335.10 http://www.cfcopies.com/juridique/droit-auteur http://www.culture.gouv.fr/culture/infos-pratiques/droits/protection.htm UNIVERSITÉ GRENOBLE-ALPES FACULTÉ DE PHARMACIE DE GRENOBLE Année : 2018 N° LES VACCINS : POURQUOI FONT-ILS PEUR ? THÈSE PRESENTÉE POUR L’OBTENTION DU TITRE DE DOCTEUR EN PHARMACIE DIPLÔME D’ÉTAT [Données à caractère personnel] Nelly GALLINO Lucie LE PENNEC [Données à caractère personnel] THÈSE SOUTENUE PUBLIQUEMENT À LA FACULTÉ DE PHARMACIE DE GRENOBLE Le : 20 Mars 2018 Directeur de thèse : Dr. Catherine GILLY, Maître de conférences en chimie thérapeutique DEVANT LE JURY COMPOSÉ DE Président du jury : Dr. Raphaële GERMI, Maître de Conférences Universitaire en microbiologie Membres : Dr. Fabienne GUTTIN-GANANSIA, Docteur en pharmacie Dr. Éric BALME, Docteur en pharmacie La Faculté de Pharmacie de Grenoble n’entend donner aucune approbation ni improbation aux opinions émises dans les thèses ; ces opinions sont considérées comme propres à leurs auteurs. Page 1 sur 190 Page 2 sur 190 Page 3 sur 190 DOMAINE DE LA MERCI – 38706 LA TRONCHE CEDEX – France - TEL : +33 (0)4 76 63 71 00 – FAX : +33 (0)4 76 63 71 70 Page 4 sur 190 REMERCIEMENTS Lucie et Nelly Nous souhaitons remercier le Dr Raphaële GERMI, pour avoir accepté de bien vouloir présider notre jury, ainsi que pour ses cours dispensés tout au long de nos études en pharmacie. Nous remercions particulièrement le Dr Catherine GILLY d’avoir accepté de diriger notre thèse et de nous avoir épaulées et conseillées pendant toute sa rédaction. Merci également au Dr Fabienne GUTTIN et au Dr Eric BALME pour avoir accepté d’être membres de notre jury, de nous avoir aidées pour cette thèse et pour nous avoir accueillies au sein de leurs officines durant nos stages. Un grand merci à Jojo et Sophie pour leur patience et leurs beaux graphiques ! Merci à tous les patients qui ont pris quelques minutes de leur temps pour répondre à notre questionnaire. Nelly Merci à toi, Lucie, d’avoir accepté d’être ma partenaire de thèse pour le meilleur et pour le pire mais surtout pour ton amitié. Merci (ou pas) au C2i qui a traumatisé mes vendredis matin de deuxième année mais qui surtout m’a permis de vous rencontrer. On en aura passé du temps ensemble à travailler sur cette thèse mais on ne retiendra que les bons moments passés et tous ceux à venir. Merci à mes parents pour votre soutien durant toutes ces années, je n’y serai jamais arrivée sans vous. Merci pour les allers-retours à Grenoble, pour les boîtes, pour les visites du Mercredi et les ravitaillements pendant les révisions. J’ai beaucoup de chance d’avoir des parents comme vous. Je vous aime. Merci à Gaylord, mon mari. Difficile de trouver les mots pour te dire à quel point je te remercie car si toutes ces années d’études n’ont pas toujours été faciles pour moi elles n’ont pas dû l’être pour toi qui les as subies. Pourtant ton amour, ta patience et ton soutien n’ont jamais failli. Avec l’achèvement de cette thèse c’est un peu une page de notre vie qui se tourne pour en commencer une nouvelle pleine de beaux projets. Je t’aime. Merci à mon frère, Vincent pour ton soutien et les bons moments passés ensemble. Même si les séances de devoirs étaient parfois houleuses tu as trouvé ta voie et je suis très fière de l’homme que tu es devenu. Merci à ma grand-mère, Elise, je vais avoir plus de temps pour venir te voir maintenant ! Merci à ma famille et à ma belle-famille qui m’a si bien accueillie. Merci à mes copines de fac Sarah, Elodie, Caroline et Anaïs pour tous ces bons moments passés ensemble et pour m’avoir donné l’envie de revenir à Grenoble après chaque vacances ! J’espère que malgré la distance et la fin de la trilogie de Grey on continuera à trouver des moments pour se voir, mais je n’en doute pas. Merci à la pharmacie de Corps, Eric et Djelil, pour m’avoir accueillie et formée durant mes stages. Page 5 sur 190 Merci à la pharmacie de Tokoro de m’avoir embauchée durant mes études. Travailler dans votre officine a été très formateur. Merci à la pharmacie des Gentianes, en particulier Isabelle, Laurie, Sabrina, Manue, Annie, Clémentine et Xavier pour ce super été passé à vos côtés. Merci à toute l’équipe du Rochasson, Fabrice, Alain le retraité, Laurence, Sylvie et Delphine de m’accueillir à présent. Lucie Merci à ma maman, Claudine, et à mon papa, Michel, pour m’avoir aidée à choisir ma voie, pour m’avoir fait confiance, et pour votre soutien indéfectible pendant toutes mes études et même bien avant. Merci pour les petits plats, pour les allers retours à la gare, et toutes les attentions que vous avez eues. Merci Papa pour avoir relu notre thèse. Merci de ne pas m’avoir mise dehors en attendant que je trouve un appart. Merci pour tout, je vous aime. Merci à mon frérot Jean pour avoir été présent et pour m’avoir supportée l’année de mon concours et après. Je te souhaite toute la réussite possible, tu le mérites vraiment. Je te souhaite aussi un très bon séjour en Suède. Tu vas me manquer. Merci à mes grands-parents paternels Guy et Manou, pour leur présence même à mille kilomètres de distance. Merci pour vos innombrables cartes postales lors de ma première année. Merci pour vos tout aussi innombrables appels sur Skype. Merci pour toutes ces belles vacances passées en Bretagne. Votre soutien a été sans aucun doute un des facteurs de ma réussite. Merci à mes grands-parents maternels Pierre et Monique pour leur soutien et leurs encouragements. Merci pour tous ces moments passés ensemble dans le Var avec toute la famille. Votre parcours, votre combativité, et vos valeurs sont un exemple à suivre pour nous tous. Vous savoir fiers de moi est la plus belle des récompenses. Et merci pour la Saxo qui m’a bien servie et me sert toujours ! Merci à mes oncles et tantes, Titi, Cricri, David, Anne pour leur soutien. Merci aussi à mes cousins et cousines Patricia, Camille, Julie et Arthur. Les moments passés avec vous sont précieux. Merci à Mathilde, une amie comme on en voit peu. La galère de la P1, on l’a connue ensemble, même si on n’était pas au même endroit. Ton amitié est une des meilleures choses qui me soit arrivées. Merci à ta maman de nous avoir présentées, nous, les deux petites nouvelles du CE2, il y a déjà 17 ans… Ça nous rajeunit pas ! Je pense que tu vas devoir me supporter encore longtemps et j’espère qu’on fera encore plein de voyages ensemble. Merci à Jessica, toujours présente depuis plus de 16 ans. Une amie précieuse et fidèle, qui m’a toujours soutenue. Toujours à côté de moi en classe, même si tu devais te mettre au premier rang. C’est comme ça qu’on reconnaît les meilleurs ! Tu es une super prof d’histoire, et je te souhaite vraiment de réussir, tu le mérites amplement. Merci à Claire, que je connais depuis toujours. Je n’oublierai pas toutes les vacances passées ensemble à Embrun ou chez tes grands-parents. Merci à Anaïs, qui m’a beaucoup soutenue pendant ma première année, et avec qui j’ai eu beaucoup de fous rires. Page 6 sur 190 Merci à Fabienne et à toute l’équipe de la pharmacie Guttin qui m’a accueillie et formée pendant mon stage de 6ème année, et qui m’a aidée à distribuer les questionnaires de cette thèse. À tous ceux que j’ai rencontré pendant mes études : Merci à toi Elodie, avec qui j’ai pu partager ma détresse lors de notre premier TP à la fac. Merci pour tous ces covoits, ces goûters, ces sorties, et d’avoir pris soin de moi comme une maman quand j’étais malade. Je remercie la fac de t’avoir mise sur ma route. Merci à toi Sarah, pour être toi. Pour ta mythomanie, pour les fous rires en cours (malaxage), pour ta bonne humeur, et pour toutes ces soirées ensemble.
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