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The Norwich Research Park Translational Fund

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The Norwich Research Park Translational Fund THE NORWICH RESEARCH PARK TRANSLATIONAL FUND CONTENTS 03 FOREWORD 18 BIOSCIENCE FOR HEALTH: 32 AGRICULTURE AND FOOD SECURITY 06 OVERVIEW MICROBES AND HEALTH 40 ICT THE PROJECTS 24 FRONTIER BIOSCIENCE 44 CHEMISTRY 12 BIOSCIENCE FOR HEALTH 28 CULTURE AND HERITAGE 46 ACKNOWLEDGEMENTS DR KAREN LEWIS EXECUTIVE DIRECTOR INNOVATION AND SKILLS BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL (BBSRC) Research and Innovation Campuses such as As BBSRC Executive Director, Innovation and Norwich Research Park form an important Skills, it was an immense pleasure to work closely component of the UK innovation ecosystem. with partners across Norwich Research Park to The Norwich Research Park hosts a thriving establish the Norwich Research Park Translation community of over 80 businesses, 3,000 Fund, with the ambition to support, develop scientists, researchers and clinicians. and nurture the innovation ecosystem across the Park. Timely access to flexible funding to enable the development of innovative ideas so that they are The Fund has kick started the development of of value to business and other users is extremely promising opportunities for commercial and important. Access to small-scale early stage societal impact from researchers across the investment is key to realising impact from the Park. It has helped foster new collaborations, UK’s world class research and capability. and encouraged a culture of enterprise and innovation. BBSRC’s vision is to ensure the power of biology delivers a healthy, prosperous and sustainable It is particularly pleasing to see how the different future in the UK and beyond. Essential to projects supported through the Fund are delivering this vision is providing access to such enabling public sector investments in world flexible and early stage investments so that class research and capability to deliver real researchers and their partners on the Park can world impacts. I look forward to seeing how the realise their ambitions and help us fulfil our projects, supported through the Fund, continue commitments to develop the bioeconomy to progress and deliver long lasting impact. and support the delivery of the UK’s Industrial Strategy. 2 3 WELCOME TO NORWICH RESEARCH PARK IS MADE UP THE NORWICH OF SIX PARTNER INSTITUTIONS: RESEARCH PARK EARLHAM INSTITUTE (EI) JOHN INNES CENTRE (JIC) NORFOLK AND NORWICH UNIVERSITY HOSPITALS (NNUH) QUADRAM INSTITUTE BIOSCIENCE (QIB) LOCATED JUST THE SAINSBURY LABORATORY (TSL) 2 THE UNIVERSITY OF EAST ANGLIA (UEA) HOURS FROM LONDON Norwich Research Park has particular strengths in plant and microbial sciences, genetics and genomics, BASED IN SIX PARTNER INSTITUTIONS ACROSS climate and geo-sciences; and food, health and human nutrition. The Park’s six institutions work collaboratively to 230 address the major global challenges faced by us all, in ACRES particular food and energy security, healthy ageing and living with environmental change. NORWICH RESEARCH PARK IS A THRIVING COMMUNITY OF OVER The Park is home to three of the Biotechnology and Biological Sciences Research Council’s (BBSRC) eight strategically funded National Institutes of Bioscience (EI, QIB, JIC) between them receiving over £50 million 3,000 p.a. in research funding from the BBSRC. SCIENTISTS, RESEARCHERS AND CLINICIANS Norwich Research Park offers a supportive and collaborative environment for businesses, with a dedicated Innovation Centre offering high quality PLUS MORE THAN office and laboratory units, ideal for innovative start ups. To find out more, visit www.norwichresearchpark. 80 com/property-and-park/availability-by-building/ BUSINESSES AND COUNTING innovation-centre 4 5 OVERVIEW THE FUND BOARD HAS ALLOCATED OVER OVERVIEW £1.6 MILLION The Norwich Research Park Translational Fund (the Fund) TO 37 PROJECTS FROM ACROSS THE PARK was established in 2014 with funding from the research OVER 3 YEARS partner institutions on the Norwich Research Park (the Park), the Biotechnology and Biological Sciences Research Council (BBSRC), and local authorities. The Fund was established with three key objectives: 1. 2. 3. Increase the likelihood Encourage researchers Support collaboration that ideas and and clinicians at all career between individuals and innovations developed stages to engage in organisations across at the Park will have a activity that will translate the Park. successful commercial their work outside to outcome or real create commercial or world impact. social impact. PROJECTS HAVE ALREADY RAISED ANOTHER To achieve these objectives, the Fund: £1 MILLION 1. 2. 3. OF FUNDING Provided early stage Contributed to delivering Operated in conjunction financial support the innovation and with later stage funding to accelerate the enterprise vision for to help projects to realise development of ideas the Park. their potential. from the excellent researchers and clinicians on the Park, to enable real world impact. Funding awarded was typically used for commissioning market assessments, technical feasibility studies, prototype development With the majority of the funding allocated, the Fund is not currently considering further applications but continues to and research to strengthen the patent positions. actively manage its portfolio of funded projects which are anticipated to be completed by June 2018. 6 7 OVERVIEW The most common sector for applications was Medicine and Health with other common sectors Projects that have been funded have already led to plans for: being Agritech, Biotechnology and Synthetic Biology, and Food and Nutrition. 11% AGRITECH NEW8 COMPANIES POTENTIAL12 LICENSING 4% DEALS IN PLACE ARTS AND HUMANITIES 12% BIOTECH AND SYNTHETIC ADDITIONAL5 INCREASED AVAILABILITY 4NEW SERVICE 46% BIOLOGY PATENT FILINGS OF RESEARCH RESULTS TO OR CONSULTANCY MEDICINE EXTERNAL USERS OFFERINGS AND HEALTH APPLICATIONS BY SECTOR 7% THE LARGEST SINGLE PROJECT FUNDED RECEIVED CHEMISTRY £52,246 7% THE AVERAGE FUNDING APPROVED FOR PROJECTS WAS ENVIRONMENTAL AND BIOLOGICAL SCIENCES £44,075 2% 12% ICT FOOD AND NUTRITION 8 9 THE PROJECTS The project portfolio is balanced across a spectrum of activities and academic disciplines to accelerate the development of promising ideas and inventions that have potential for societal impact or commercial application. The following 37 projects are grouped under seven themes. THEMES: INSTITUTIONS: Bioscience for health Earlham Institute (EI) – formerly The Genome Analysis Centre Bioscience for health: Microbes and health John Innes Centre (JIC) Frontier bioscience Norfolk and Norwich University Hospital (NNUH) Agriculture and food security Quadram Institute Bioscience (QIB) – Culture and heritage formerly the Institute of Food Research ICT The Sainsbury Laboratory (TSL) Chemistry University of East Anglia (UEA) EXTERNAL PARTNERS: Iceni Fund Low Carbon Innovation Fund Plant Bioscience Limited (PBL) UK Innovation and Science Seed Fund 10 11 BIOSCIENCE FOR HEALTH BIOSCIENCE NORWICH SKIN PLATFORM DR JELENA GAVRILOVIC (UEA) DR DAMON BEVAN (UEA) FOR HEALTH PROF CATHIE MARTIN (JIC) PROF JEREMY TURNER (NNUH) PROF MARC MONCRIEFF (NNUH) DR JONATHAN CLARKE (JIC) DR GEORGINA POPE (UEA – KNOWLEDGE EXCHANGE LEAD) A 3D PRINTED SYNTHETIC SCAFFOLD New products and medicines that impact clinical partners at the Norfolk and Norwich NSP combines scientific, clinical and technical on skin conditions are continuously being University Hospital (NNUH) they developed know-how to perform “in-house” assays (lab- FOR EX-VIVO HUMAN COLONIC developed and there is an urgent need for a model with many small pieces of the surplus based investigative procedures) to provide a TISSUE CULTURE MODEL ways to test them on human skin. Testing skin, which can survive long enough outside range of analytics. In addition, NSP’s whole therapeutics and compounds directly on the body to test in the laboratory a number of skin assay has more biological relevance than DR ARAM SAEED (UEA) DR MARK WILLIAMS (UEA) a model of human skin provides the gold different products and treatments, including commonly-used reconstituted skin or cell- DR GEORGINA POPE (UEA – KNOWLEDGE EXCHANGE LEAD) standard to identify their potential beneficial new plant extracts. This human skin testing based assays, due to the complex interplay of use on skin and addresses ethical concerns model, which can be used to test potential the numerous skin components and different regarding the numbers of animals used in compounds active in skin disease, will very cell types present in whole skin. Before being given to patients, potential new more like they would in the patient than the the development of therapeutics. In addition likely reduce the number of animals used in drugs are tested on cells grown in the laboratory. conventional plastic surfaces currently used. established differences between human and therapeutics development. NSP also provides Since receiving initial funding, the project has Laboratory cells are grown on flat plastic mouse skin make human skin testing models access to a more relevant testing regime for been awarded BBSRC Business Interaction surfaces which is a very artificial and unnatural Dr Saeed and Dr Williams are developing a very attractive. Human models are also innovative industry. Vouchers with two different SMEs, as well method since the surfaces bear no resemblance bespoke 3D synthetic matrix. This product is required in the cosmetics arena where animal as a grant from the Big C cancer charity for to the bodily environments in which cells unique as it uses cells provided by the NNUH testing is not permitted in the UK or rest
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