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Extensive Exposure to Tear Gases in Ankara
Turk Thorac J 2019 DOI: 10.5152/TurkThoracJ.2018.18096 Original Article Extensive Exposure to Tear Gases in Ankara Aslıhan Ilgaz1 , Filiz Çağla Küçük Uyanusta2 , Peri Arbak3 , Arif Müezzinoğlu4 , Tansu Ulukavak Çiftçi5 , Serdar Akpınar6 , Hikmet Fırat6 , Selma Fırat Güven7 , Bülent Çiftçi8 , Selen Karaoğlanoğlu9 , Elif Dağlı10 , Feyza Erkan11 1Clinic of Pulmonary Diseases, Middle East Technical University, Medical Center, Ankara, Turkey 2Clinic of Pulmonary Diseases, ARTE Hekimköy Medical Center, Ankara, Turkey 3Department of Chest Diseases, Düzce University School of Medicine, Düzce, Turkey 4Ankara Chamber of Medical Doctors, Commission of Workers’ Health and Occupational Physicians, Ankara, Turkey 5Department of Pulmonary Diseases, Gazi University School of Medicine, Ankara, Turkey 6Clinic of Chest Diseases, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey 7Sleep Disorders Center, Atatürk Chest Diseases, Thoracic Surgery Training and Research Hospital, Ankara, Turkey 8Department of Pulmonary Diseases, Bozok University School of Medicine, Yozgat, Turkey 9Department of Pulmonary Diseases, Ordu University School of Medicine, Ordu, Turkey 10Clinic of Child Chest Diseases, Acıbadem Fulya Hospital, İstanbul, Turkey 11Department of Pulmonary Medicine, İstanbul University İstanbul School of Medicine, İstanbul, Turkey Cite this article as: Ilgaz A, Küçük Uyanusta FÇ, Arbak P, et al. Extensive Exposure to Tear Gases in Ankara. Turk Thorac J 2019; DOI: 10.5152/TurkThoracJ.2018.18096 Abstract OBJECTIVES: The most common chemical substances used as mass control agents are chloroacetophenone, chlorobenzylidene malono- nitrile, and oleoresin capsicum. These agents not only have local and rapid effects but also have systemic and long-term effects. The aim of the present study was to discuss the patterns of tear gas exposure and to investigate its effects on respiratory functions. -
Current Awareness in Clinical Toxicology Editors: Damian Ballam Msc and Allister Vale MD
Current Awareness in Clinical Toxicology Editors: Damian Ballam MSc and Allister Vale MD April 2015 CONTENTS General Toxicology 9 Metals 44 Management 22 Pesticides 49 Drugs 23 Chemical Warfare 51 Chemical Incidents & 36 Plants 52 Pollution Chemicals 37 Animals 52 CURRENT AWARENESS PAPERS OF THE MONTH Acute toxicity profile of tolperisone in overdose: observational poison centre-based study Martos V, Hofer KE, Rauber-Lüthy C, Schenk-Jaeger KM, Kupferschmidt H, Ceschi A. Clin Toxicol 2015; online early: doi: 10.3109/15563650.2015.1022896: Introduction Tolperisone is a centrally acting muscle relaxant that acts by blocking voltage-gated sodium and calcium channels. There is a lack of information on the clinical features of tolperisone poisoning in the literature. The aim of this study was to investigate the demographics, circumstances and clinical features of acute overdoses with tolperisone. Methods An observational study of acute overdoses of tolperisone, either alone or in combination with one non-steroidal anti-inflammatory drug in a dose range not expected to cause central nervous system effects, in adults and children (< 16 years), reported to our poison centre between 1995 and 2013. Current Awareness in Clinical Toxicology is produced monthly for the American Academy of Clinical Toxicology by the Birmingham Unit of the UK National Poisons Information Service, with contributions from the Cardiff, Edinburgh, and Newcastle Units. The NPIS is commissioned by Public Health England Results 75 cases were included: 51 females (68%) and 24 males (32%); 45 adults (60%) and 30 children (40%). Six adults (13%) and 17 children (57%) remained asymptomatic, and mild symptoms were seen in 25 adults (56%) and 10 children (33%). -
Scientific Advisory Board
OPCW Scientific Advisory Board SAB-III/1 27 April 2000 Original: ENGLISH REPORT OF THE THIRD SESSION OF THE SCIENTIFIC ADVISORY BOARD 1. Introduction 1.1 The Scientific Advisory Board (hereinafter referred to as the “Board”) held two meetings during its third session, which took place from 14 - 16 December 1999 and from 15 - 16 March 2000 in The Hague. 1.2 Dr Claude Eon of France, the Chairman of the Board, presided over its proceedings. 1.3 The Board considered the following issues: (a) adamsite; (b) analytical procedures; (c) equipment issues; (d) destruction technologies; (e) bio-medical samples; (f) future contributions of the Board to the preparation of the first Review Conference; and (g) any other business. 1.4 In preparation for its meeting the Board had received reports from its temporary working groups (TWGs) on adamsite and analytical procedures, and a report on a joint meeting of the temporary working groups on equipment issues and on chemical weapons destruction technologies. 1.5 During its meeting in December 1999, the Board received a briefing by the Deputy Director-General on the status of implementation of the Convention and on work priorities. The Board was also briefed by staff from the Verification and Inspectorate Divisions on experiences with the conduct of different types of inspection, as well as on analytical and equipment-related matters. It was further briefed on the results of an expert meeting on bio-medical samples conducted by the Secretariat in December 1999. CS-2000-1867 SAB-III/1 page 2 2. Work on substantive issues Adamsite 2.1 The Board received and discussed the draft report of the TWG on adamsite dated 7 October 1999, noted additional comments, and decided to include in its report the following considerations in relation to this matter: 2.2 Adamsite (10-chloro-5,10-dihydro-phenarsazine, code name DM, CAS registry number 578-94-9) is a yellow-green crystalline solid with a boiling point of 410ºC and a melting point of 195ºC. -
Copyrighted Material
1 Historical Milieu 1.1 Organophosphorus Nerve Agents 2 1.2 Blister Agents 5 1.3 Sternutator Agents 11 1.4 Chemical Weapons Convention (CWC) 13 1.4.1 Schedule of Chemicals 14 1.4.2 Destruction of Chemical Weapons 14 References 16 COPYRIGHTED MATERIAL Analysis of Chemical Warfare Degradation Products, First Edition. Karolin K. Kroening, Renee N. Easter, Douglas D. Richardson, Stuart A. Willison and Joseph A. Caruso. © 2011 John Wiley & Sons, Ltd. Published 2011 by John Wiley & Sons, Ltd. 2 ANALYSIS OF CHEMICAL WARFARE DEGRADATION PRODUCTS 1.1 ORGANOPHOSPHORUS NERVE AGENTS Organophosphorus (OP) type compounds, that is, deriva- tives containing the P=O moiety, were first discovered in the 1800s when researchers were investigating useful applica- tions for insecticides/rodenticides. There are many derivatives of organophosphorus compounds, however, the OP deriva- tives that are typically known as ‘nerve agents’ were discov- ered accidentally in Germany in 1936 by a research team led by Dr. Gerhard Schrader at IG Farben [1–4]. Schrader had noticed the effects and lethality of these organophosphorus compounds towards insects and began developing a new class of insecticides. While working towards the goal of an improved insecticide, Schrader experimented with numerous phosphorus-containing compounds, leading to the discovery of the first nerve agent, Tabun (or GA) (Figure 1.1). The potency of these insecticides towards humans was not realized until there was yet another accident, which involved a Tabun spill. Schrader and coworkers began experiencing symptoms, such as miosis (constriction of the pupils of the eyes), dizziness and severe shortness of breath, with numerous effects lasting several weeks [1, 4, 5]. -
Chapter Four – TRPA1 Channels: Chemical and Temperature Sensitivity
CHAPTER FOUR TRPA1 Channels: Chemical and Temperature Sensitivity Willem J. Laursen1,2, Sviatoslav N. Bagriantsev1,* and Elena O. Gracheva1,2,* 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA 2Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA *Corresponding author: E-mail: [email protected], [email protected] Contents 1. Introduction 90 2. Activation and Regulation of TRPA1 by Chemical Compounds 91 2.1 Chemical activation of TRPA1 by covalent modification 91 2.2 Noncovalent activation of TRPA1 97 2.3 Receptor-operated activation of TRPA1 99 3. Temperature Sensitivity of TRPA1 101 3.1 TRPA1 in mammals 101 3.2 TRPA1 in insects and worms 103 3.3 TRPA1 in fish, birds, reptiles, and amphibians 103 3.4 TRPA1: Molecular mechanism of temperature sensitivity 104 Acknowledgments 107 References 107 Abstract Transient receptor potential ankyrin 1 (TRPA1) is a polymodal excitatory ion channel found in sensory neurons of different organisms, ranging from worms to humans. Since its discovery as an uncharacterized transmembrane protein in human fibroblasts, TRPA1 has become one of the most intensively studied ion channels. Its function has been linked to regulation of heat and cold perception, mechanosensitivity, hearing, inflam- mation, pain, circadian rhythms, chemoreception, and other processes. Some of these proposed functions remain controversial, while others have gathered considerable experimental support. A truly polymodal ion channel, TRPA1 is activated by various stimuli, including electrophilic chemicals, oxygen, temperature, and mechanical force, yet the molecular mechanism of TRPA1 gating remains obscure. In this review, we discuss recent advances in the understanding of TRPA1 physiology, pharmacology, and molecular function. -
The Emerging Role of Transient Receptor Potential Channels in Chronic Lung Disease
BACK TO BASICS | TRANSIENT RECEPTOR POTENTIAL CHANNELS IN CHRONIC LUNG DISEASE The emerging role of transient receptor potential channels in chronic lung disease Maria G. Belvisi and Mark A. Birrell Affiliation: Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK. Correspondence: Maria G. Belvisi, Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Imperial College, Exhibition Road, London SW7 2AZ, UK. E-mail: [email protected] @ERSpublications Transient receptor potential channels are emerging as novel targets for chronic lung diseases with a high unmet need http://ow.ly/GHeR30b3hIy Cite this article as: Belvisi MG, Birrell MA. The emerging role of transient receptor potential channels in chronic lung disease. Eur Respir J 2017; 50: 1601357 [https://doi.org/10.1183/13993003.01357-2016]. ABSTRACT Chronic lung diseases such as asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis are a major and increasing global health burden with a high unmet need. Drug discovery efforts in this area have been largely disappointing and so new therapeutic targets are needed. Transient receptor potential ion channels are emerging as possible therapeutic targets, given their widespread expression in the lung, their role in the modulation of inflammatory and structural changes and in the production of respiratory symptoms, such as bronchospasm and cough, seen in chronic lung disease. Received: Jan 08 2017 | Accepted after revision: April 14 2017 Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com Copyright ©ERS 2017 https://doi.org/10.1183/13993003.01357-2016 Eur Respir J 2017; 50: 1601357 TRANSIENT RECEPTOR POTENTIAL CHANNELS IN CHRONIC LUNG DISEASE | M.G. -
Report on Chemical Munitions Dumped in the Baltic Sea (HELCOM 1994)
Baltic Sea Environment Proceedings No. 142 Baltic Marine Environment Protection Commission Chemical Munitions Dumped in the Baltic Sea Published by: HELCOM – Baltic Marine Environment Protection Commission Katajanokanlaituri 6 B FI-00160 Helsinki Finland www.helcom.fi Authors: Tobias Knobloch (Dr.), Jacek Bełdowski, Claus Böttcher, Martin Söderström, Niels-Peter Rühl, Jens Sternheim For bibliographic purposes this document should be cited as: HELCOM, 2013 Chemical Munitions Dumped in the Baltic Sea. Report of the ad hoc Expert Group to Update and Review the Existing Information on Dumped Chemical Munitions in the Baltic Sea (HELCOM MUNI) Baltic Sea Environment Proceeding (BSEP) No. 142 Number of pages: 128 Information included in this publication or extracts thereof are free for citation on the condition that the complete reference of the publication is given as stated above Copyright 2013 by the Baltic Marine Environment Protection Commission (HELCOM) ISSN 0357-2994 Language revision: Howard McKee Editing: Minna Pyhälä and Mikhail Durkin Design and layout: Leena Närhi, Bitdesign, Vantaa, Finland Chemical Munitions Dumped in the Baltic Sea Report of the ad hoc Expert Group to Update and Review the Existing Information on Dumped Chemical Munitions in the Baltic Sea (HELCOM MUNI) Table of Contents 1 Executive summary. .5 2 Introduction. .9 2.1 CHEMU report – subjects covered, recommendations & fulfilment. .10 2.2 MUNI report – scope & perspectives. 11 2.3 National and international activities since 1995. .14 2.3.1 Managerial initiatives. .14 2.3.2 Investigations in the Baltic Sea . .23 3 Chemical warfare materials dumped in the Baltic Sea. .28 3.1 Introduction. 29 3.1.1 Dumping activities . -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles. -
Policing in Ames - a Path Forward
POLICING IN AMES - A PATH FORWARD September 29, 2020 BACKGROUND: As in other cities throughout the country, after the death of George Floyd while in police custody, the City Council began receiving an extraordinary amount of feedback regarding the manner in which our law enforcement and criminal justice systems are being operated. This input has included questions about policing philosophy and operations as well as suggestions/recommendations/demands to modify how the Ames Police Department functions in those areas. Rather than respond individually to this input over time, the City Council requested that the City Manager compile all the correspondence received, consolidate this information into common themes, and provide recommendations regarding how to address each theme. The following is a list of the common themes: THEME PAGES I. Organizational Culture 2-3 II. Police Officer Recruitment and Selection Process 4-7 III. Police Officer Training/Education 8-10 IV. Departmental Policies 11-23 V. City Ordinances and State Law 24-27 VI. Transparency 28-29 VII. Accountability in Complaint Handling and Discipline 30-37 VIII. Communication 38-39 IX. Funding 40-42 This report is structured to deal with each theme separately, highlighting: 1) What has been suggested, 2) What the City is currently doing in regard to each theme, and 3) the City Manager’s recommendations to address each theme. The recommendations reflected in this report were influenced by the following sources: • Community member suggestions • Police Department staff suggestions • Peer department activities and services • Guidance from the President’s Task Force on 21st Century Policing 1 THEME I – ORGANIZATIONAL CULTURE WHAT HAS BEEN SUGGESTED? Many individuals who provided input wanted to ensure that there is not a culture of racial bias embedded in the Ames Police Department. -
Law Enforcement's Use of Weaponized Drones
SAINT LOUIS UNIVERSITY SCHOOL OF LAW LAW ENFORCEMENT’S USE OF WEAPONIZED DRONES: TODAY AND TOMORROW INTRODUCTION What do children, adults, photographers, farmers, utilities, agriculture, oil and manufacturing companies, and law enforcement have in common? They all asked for a drone for Christmas. In fact, the Federal Aviation Administration (“FAA”) became concerned in October of 2015 with reports of at least one million Americans likely to find a drone under the tree on Christmas morning.1 However, one of these things is not like the other. While children, adults, farmers, and companies are using drones to monitor their own activities, law enforcement agencies are using drones to monitor the activities of others.2 While a step in the right direction for those concerned with the safety of our police officers, some see this as a platform for constitutional issues.3 Amongst these varying points of view are residents of North Dakota, where a bill was passed with the intention to enumerate and limit law enforcement’s use of drones.4 However, after a close reading of the finalized bill, the text itself may actually expand law enforcement’s use of drones, rather than limit it.5 North Dakota passed House Bill 1328 into law on April 16, 2015, which “provide[s] for limitations on the use of unmanned aircraft for surveillance.”6 The purpose of the act was to restrict law enforcement’s use of drones for 7 surveillance efforts in the collection of criminal evidence. Along with these 1. Dan Reed, A Million Drones for Christmas? FAA Frets the Threat for Planes, FORBES (Oct. -
Pepper Spray: What Do We Have to Expect?
Pepper Spray: What Do We Have to Expect? Assoc. Prof. Mehmet Akif KARAMERCAN, MD Gazi University School of Medicine Department of Emergency Medicine Presentation Plan • History • Pepper Spray • Tear Gas • Symptoms • Medical Treatment • If you are the victim ??? History • PEPPER SPRAY ▫ OC (oleoresin of capsicum) (Most Commonly Used Compound) • TEAR GAS ▫ CN (chloroacetophenone) (German scientists 1870 World War I and II) ▫ CS (orthochlorobenzalmalononitrile) (US Army adopted in 1959) ▫ CR (dibenzoxazepine) (British Ministry of Defence 1950-1960) History of Pepper Spray • Red Chili Pepper was being used for self defense in ancient India - China - Japan (Ninjas). ▫ Throw it at the faces of their enemies, opponents, or intruders. • Japan Tukagawa Empire police used a weapon called the "metsubishi." • Accepted as a weapon ▫ incapacitate a person temporarily. • Pepper as a weapon 14th and 15th century for slavery rampant and became a popular method for torturing people (criminals, slaves). History of Pepper Spray • 1980's The USA Postal Workers started using pepper sprays against dogs, bears and other pets and became a legalized non-lethal weapon ▫ Pepper spray is also known as oleoresin of capsicum (OC) spray • The FBI in 1987 endorse it as an official chemical agent and it took 4 years it could be legally accepted by law enforcement agency. Pepper Spray • The active ingredient in pepper spray is capsaicin, which is a chemical derived from the fruit of plants of chilis. • Extraction of Oleoresin Capsicum from peppers ▫ capsicum to be finely ground, capsaicin is then extracted using an organic solvent (ethanol). The solvent is then evaporated, remaining waxlike resin is the Oleoresin Capsicum • Propylene Glycol is used to suspend the OC in water, pressurized to make it aerosol in Pepper Spray. -
Negative Effects of the Use of Militarization Methods by the Police Force
Negative Effects of the Use of Militarization Methods by the Police Force Children and Adults Developmental Agency Programs, Inc. (CADAprograms) Commission on the Status of Women (CSW 65) United Nations Citizens to Abolish Domestic Apartheid, Inc 2901 Maryland Ave., P.O. Box 80 North Versailles, PA 15137 Phone: (412) 829-2711 Fax: (412) 829-2788 Email: [email protected] Website: www.cadaprograms.org Committee: Chemical Pollutant Eradication Council Chair: Dr. Janis C. Brooks 1 Presentation Outline Riot Control Agents Exposure to a riot control agent Health effects of exposure to riot control agents Treatment for riot control agents Protection and exposure to riot control agents Rubber Bullets The Americans With Disabilities Act And Law Enforcement Summary 2 Riot Control Agents Chloroacetophenone (CN) Chlorobenzylidenemalononitrile (CS) Other examples include: • Chloropicrin (PS), used as a fumigant (that is, a substance that uses fumes to disinfect an area); • Bromobenzylcyanide (CA); • Dibenzoxazepine (CR); and combinations of various agents. 3 Exposure to a riot control agent How you could be exposed to riot control agents. Fine droplets or particles Skin contact, Eye contact, or Breathing. How riot control agents work. The extent of poisoning Irritation of the area of contact (for example, eyes, skin, nose) The effects of exposure to a riot control agent 4 Health effects of exposure to riot control agents Symptoms immediately after exposure: Eyes: excessive tearing, burning, blurred vision, redness Nose: runny