2020 Annual Report
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2020 ANNUAL REPORT TABLE OF EDITORIAL 10 YEARS OF PROGRESS CONTENTS & INNOVATION • Paris Brain Institute, a revolutionary model to accelerate the fight against brain diseases .p8 • Highlights 2020 .p10 • Our research team’s achievements .p13 • Key Figures .p14 RESEARCH • 2020, a year filled with scientific breakthroughs.p16 • Cutting-edge technological platforms .p26 • IHU, Paris Institute of Translational Neuroscience .p30 • Paris Brain Institute teams .p32 • Internationnal partnerships .p34 CLINICAL RESEARCH AND CARE • COVID-19 Pandemic : the Institute’s clinical forces unite .p36 • The Clinical Investigation Center works towards tailored treatment for each patient .p38 INNOVATION AND KNOWLEDGE TRANSFER • Research applications .p40 • Open Brain School .p44 PARIS BRAIN INSTITUTE • Human resources .p46 • Governance .p48 • Financial report .p51 • Communications and Development .p56 © Inserm/Dournaud, Pascal. Groupe Publicis. Mathieu Génon. Jimmy Delpire. Bioserenity. Guillaume Miquel. • Thank You .p60 Nicolas Renier. Théo Ribierre. Alexandre Bône. John Bersi. Julien Pigeon. Jean-Philippe Pariente. ” AS WE LOOK BACK ON THE DESPITE CONTINUING UNCERTAINTIES, WE YEAR 2020, WE MUST FIRST THINK HAVE CONTINUED TO EVOLVE AND GROW. DESPITE THE PANDEMIC, THE INSTITUTE UPHELD A OF ALL THOSE WHO HAVE BEEN THE CHEVALERET CAMPUS, AN INCUBATOR REMARKABLE RESEARCH DYNAMIC IN 2020 WITH DEDICATED TO MEDICAL TECHNOLOGIES AFFECTED, ARE STILL AFFECTED CONTINUED SUCCESS, INCLUDING THE RECRUITMENT AND ARTIFICIAL INTELLIGENCE, WHICH OR HAVE DISAPPEARED BECAUSE OF SEVERAL RESEARCHERS, AWARDS, AND HIGHLY OF COVID-19. WE HAVE ALL BEEN WILL OPEN IN 2021, PROMISES GREAT COMPETITIVE FUNDING INCLUDING OUR 15TH ERC AFFECTED PHYSICALLY, SOCIALLY AND SUCCESS; THE GREATER INTEGRATION (EUROPEAN RESEARCH COUNCIL) GRANT. THIS OF THE PARIS BRAIN INSTITUTE IN THE ECONOMICALLY. IN THIS DIFFICULT YEAR ALSO SAW AN UNPARALLELED NUMBER OF VARIOUS ASPECTS OF CLINICAL RESEARCH, PERIOD, THE PARIS BRAIN INSTITUTE PUBLICATIONS FROM OUR RESEARCHERS IN TOP IN CLOSE COLLABORATION WITH THE HAS SHOWN A FANTASTIC CAPACITY SCIENTIFIC AND MEDICAL JOURNALS. THIS IS A DIRECT MEDICAL-UNIVERSITY DEPARTMENT FOR ADAPTABILITY, FLEXIBILITY OF NEUROSCIENCES AT THE PITIÉ- RESULT OF AMBITIOUS AND HIGH-RISK PROJECTS AND REACTIVITY. TOWARDS THE SALPÊTRIÈRE HOSPITAL; THE PURSUIT OF LAUNCHED 3 TO 5 YEARS AGO THAT ARE COMING TO HOSPITAL, WITH THE MOBILISATION OF HIGH-LEVEL RESEARCH ON NEUROLOGICAL FRUITION. HUMAN AND MATERIAL RESOURCES; AND PSYCHIATRIC DISEASES, BUT ALSO THE INSTITUTE WAS ALSO INVOLVED IN RESEARCH TOWARDS ITS STAFF, TO GUARANTEE ON THE FUNDAMENTAL UNDERSTANDING ON COVID-19 WITH THE LAUNCH OF THE COVID THEIR SAFETY AND TO DEVELOP OF THE BRAIN IN NORMAL CONDITIONS, NEUROSCIENCE COHORT TO STUDY NEUROLOGICAL SALIVARY TESTS TO DETECT COVID-19; THE PROGRESSION OF ARTIFICIAL AND PSYCHIATRIC CONSEQUENCES OF SARS-COV-2 TOWARDS SCIENCE, BY DEVELOPING INTELLIGENCE AND THE IMPROVEMENT OF INFECTION. NEW RESEARCH SUCH AS THE COVID COGNITIVE CAPACITIES. NEUROSCIENCE COHORT TO MONITOR I WOULD LIKE TO TAKE A MOMENT TO ACKNOWLEDGE THE NEUROLOGICAL AND PSYCHIATRIC I WOULD LIKE TO THANK YOU, PARTNERS, PROF JEAN-YVES DELATTRE, OUR INSTITUTE’S CONSEQUENCES OF COVID-19, AND DONORS AND VOLUNTEERS, FOR YOUR MEDICAL DIRECTOR AND DIRECTOR OF THE MEDICAL- BY CONTINUING ITS WORK ON THE INVOLVEMENT AND YOUR UNFAILING UNIVERSITY NEUROSCIENCE DEPARTMENT AT NERVOUS SYSTEM, MAINTAINING SUPPORT FOR THE PARIS BRAIN INSTITUTE PITIÉ-SALPÊTRIÈRE AP-HP HOSPITAL, WHO RETIRED A HIGH LEVEL OF SCIENTIFIC IN THIS VERY SPECIAL CONTEXT. THE LAST NOVEMBER. HIS RETIREMENT WAS A VERY PUBLICATIONS. RESEARCH CARRIED OUT HERE IS ONLY ” IN THE FACE OF COVID-19, THE ENTIRE PARIS Prof. Gérard Saillant, TOUCHING MOMENT FOR THE INSTITUTE COMMUNITY, POSSIBLE THANKS TO THE MOBILISATION BRAIN INSTITUTE COMMUNITY HAS PROVEN ITS President of AND A TRIBUTE TO HIS CONCERN FOR HUMANKIND OF EVERYONE. ” STRENGTH, ABILITY TO DESIGN NEW APPROACHES, Paris Brain Institute AND HIS EXCEPTIONAL INVOLVEMENT. PROF NEW PROJECTS, LEADING TO MANY SCIENTIFIC CATHERINE LUBETZKI IS TAKING OVER TO CONTINUE BREAKTHROUGHS. ALTHOUGH THE PANDEMIC IS OUR ACTIONS TO REINFORCE THE RELATIONSHIP NOWHERE NEAR OVER, I AM CONFIDENT THAT IT BETWEEN OUR INSTITUTE AND CLINICAL UNITS AT THE REINFORCED OUR COLLECTIVE VALUES AND THAT HOSPITAL. PATIENTS ARE TRULY AT THE HEART OF ” THE COVID-19 PANDEMIC RADICALLY CHANGED OUR PROFESSIONAL LIVES THESE HAVE BECOME A MAJOR STRENGTH FOR OUR RESEARCH. AND FORCED US TO REINVENT THE WAY WE WORK. OUR MODEL AND THE THE INSTITUTE. “SAFETY”, “ANTICIPATION” AND STRENUOUS FLEXIBILITY WE APPLY ON A DAY-TO-DAY BASIS HAVE PROVEN “CONTINUITY” HAVE BEEN OUR KEYWORDS IN THIS WE KNOW THAT THE NEXT FEW MONTHS WILL REMAIN THEIR STRENGTHS IN THIS TIME AND ALLOWED US TO MAINTAIN A HIGH CRISIS SINCE DAY ONE. THANKS TO THE SUPPORT UNCERTAIN AS WE WAIT FOR VACCINATION LEVELS LEVEL OF EFFICACY. THROUGH COLLABORATION, PERMANENT AND FLEXIBLE OF OUR IT TEAMS, WE ADAPTED TO THE SITUATION TO RISE. IN ADDITION TO PROTECTING HEALTH AND COMMUNICATION AND HIGH STANDARDS, WE WERE ABLE TO ENSURE THAT PROMPTLY TO ENABLE WORKING FROM HOME AS WELL-BEING, WE MUST ALSO PROTECT OUR RESEARCH EVERYONE CONTINUED TO WORK IN THE BEST CONDITIONS. FOR TEAMS TO MUCH AS POSSIBLE. WORKING CONDITIONS ON-SITE DYNAMIC. DEVELOPING NEW COLLABORATIONS AND DEDICATE THEMSELVES FULLY TO RESEARCH, WITH LIMITED ADMINISTRATIVE WERE ALSO ADAPTED AND MADE SAFE WITH THE INTERDISCIPLINARY APPROACHES, GROUNDBREAKING CONSTRAINTS. FOR PLATFORMS TO ENSURE OPTIMAL SERVICE AND SUPPORT SUPPORT OF OUR LOGISTICS TEAMS AND RESPECTED PROJECTS ON THE NERVOUS SYSTEM AND TEAMS WHILE DEVELOPING THEIR ORGANIZATION. FOR SUPPORT TEAMS PHYSICAL DISTANCING BY EACH AND EVERY ONE ITS PATHOLOGIES, AND INVESTING IN NOVEL TO REMAIN AS OPEN AS POSSIBLE TO RESEARCH TEAMS WHILE MAKING OF US AT THE INSTITUTE. THE INSTITUTE ALSO TECHNOLOGY DEVELOPMENT REMAIN ABSOLUTELY SURE THAT WE FOLLOW THE NECESSARY RULES FOR THE SITUATION. THE IMPLEMENTED AND CARRIED OUT COVID-19 SALIVA ESSENTIAL. MEDICAL RESEARCH MUST REMAIN A INVOLVEMENT OF THE ENTIRE INSTITUTE COMMUNITY IS WHAT HAS MADE PCR TESTS ON A VOLUNTARY AND ANONYMOUS BASIS PRIORITY FOR SOCIETY, AND WE HAVE AN A MAJOR SUCCESS POSSIBLE TODAY AND WILL GUARANTEE THE SUCCESS OF FUTURE FOR INSTITUTE PERSONNEL, TO ENSURE OUR STAFF’S ROLE TO PLAY. ” ORGANIZATIONAL AND SCIENTIFIC PROJECTS AS WELL. ” SAFETY. Corinne Fortin, Prof. Alexis Brice, Secretary General of Paris Brain Institute Executive Director of Paris Brain Institute 6 • PARIS BRAIN INSTITUTE • 2020 ANNUAL REPORT A decade of progress and innovations ICM receives state certification as part of the ICM’s funding ”French Tech Seed” fund managed by Bpifrance. is renewed and This certification confirms the dynamic strategy supplemented for PARIS BRAIN INSTITUTE, implemented by the iPEPS bio-incubator to promote the IHU program. entrepreneurship with strong expertise in the fields of A REVOLUTIONARY MODEL neurology and psychiatry. 2019 TO ACCELERATE THE FIGHT Identification of compensation 2018 mechanisms in Alzheimer’s disease with the INSIGHT cohort of elderly subjects by Professor Bruno Dubois’s Open Brain AGAINST BRAIN (AP-HP, Sorbonne Université) team School DISEASES with Pitié-Salpêtrière Hospital. PARIS Paris Brain Institute launches its training center, Open Brain School, to share neuroscience knowledge and strengthen training for future researchers and doctors on a national and international level. PARIS BRAIN INSTITUTE WAS BUILT ON THE INVOLVEMENT OF CELEBRITIES AND PUBLIC INSTITUTIONS WITH A SHARED GOAL : UNDERSTANDING THE 2017 BRAIN AND TREATING NEUROLOGICAL Creation of the AND PSYCHIATRIC ILLNESS. Neuroinformatics Center for cutting-edge research and medicine. 2003 - 2010 An idea turns into a project, driven by hope and motivation ! Thanks to the founding members, donors and public stakeholders, the Institute comes to life: in 2020, the Paris Brain Institute building was inaugurated within Pitié-Salpêtrière Hospital in Paris. 2011 Development of a new 2016 imaging technique to visualize The Clinical Investigation Center (AP-HP, remyelination in patients with Inserm) opens its doors to patients taking multiple sclerosis, impossible part in clinical trials within the Institute. to see with classic imaging 2014 techniques. Obtaining the Carnot label, to accelerate the development of new Acquisition and operation technologies in the fields of neurology and psychiatry of a PET-MRI with AP-HP, the first in France with both Along with its institutional clinical and research use. 2015 partners, the Institute 2012 receives certification as a “Center for excellence in ICM becomes one of 6 centers for scientific neurodegenerative diseases” and medical excellence supported by the as part of a national program on Investments in the Future project implemented Bioserenity, a startup incubated at Paris neurodegenerative diseases. by the Ministry of Higher Education and Brain Institute, designs the Neuronaut : Research and the Ministry of Health (IHU). smart clothing for at-home care and monitoring of patients with epilepsy.Today, Bioserenity has Inauguration of iPEPS-ICM, the over 500 employees worldwide. The company first startup incubator dedicated to is part of the Next 40, an index created by the nervous system diseases. French government in 2019 to track the 40 8 • PARIS BRAIN INSTITUTE • 2020 ANNUAL REPORT 2020 ANNUAL REPORT • PARIS BRAIN INSTITUTE • 9 French start-ups with very high potential. A decade of progress and innovations