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Genome-Wide Association Study of Pulse Pressure and Mean Arterial Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure Supplementary Information Louise V Wain, Germaine C Verwoert, Paul F O’Reilly, Gang Shi, Toby Johnson, Andrew D Johnson, Murielle Bochud, Kenneth M Rice, Peter Henneman, Albert V Smith, Georg B Ehret, Najaf Amin, Martin G Larson, Vincent Mooser, David Hadley, Marcus Dörr, Joshua C Bis, Thor Aspelund, Tõnu Esko, A Cecile JW Janssens, Jing Hua Zhao, Simon Heath, Maris Laan, Jingyuan Fu, Giorgio Pistis, Jian’an Luan, Pankaj Arora, Gavin Lucas, Nicola Pirastu, Irene Pichler, Anne U Jackson, Rebecca J Webster, Feng Zhang, John F Peden, Helena Schmidt, Toshiko Tanaka, Harry Campbell, Wilmar Igl, Yuri Milaneschi, Jouke-Jan Hottenga, Veronique Vitart, Daniel I Chasman, Stella Trompet, Jennifer L Bragg-Gresham, Behrooz Z Alizadeh, John C Chambers, Xiuqing Guo, Terho Lehtimäki, Brigitte Kühnel, Lorna M Lopez, Ozren Polašek, Mladen Boban, Christopher P Nelson, Alanna C Morrison, Vasyl Pihur, Santhi K Ganesh, Albert Hofman, Suman Kundu, Francesco US Mattace-Raso, Fernando Rivadeneira, Eric JG Sijbrands, Andre G Uitterlinden, Shih-Jen Hwang, Ramachandran S Vasan, Thomas J Wang, Sven Bergmann, Peter Vollenweider, Gérard Waeber, Jaana Laitinen, Anneli Pouta, Paavo Zitting, Wendy L McArdle, Heyo K Kroemer, Uwe Völker, Henry Völzke, Nicole L Glazer, Kent D Taylor, Tamara B Harris, Helene Alavere, Toomas Haller, Aime Keis, Mari-Liis Tammesoo, Yurii Aulchenko, Inês Barroso, Kay-Tee Khaw, Pilar Galan, Serge Hercberg, Mark Lathrop, Susana Eyheramendy, Elin Org, Siim Sõber, Xiaowen Lu, Ilja M Nolte, Brenda W Penninx, Tanguy Corre, Corrado Masciullo, Cinzia Sala, Leif Groop, Benjamin F Voight, Olle Melander, Christopher J O’Donnell, Veikko Salomaa, Adamo Pio d’Adamo, Antonella Fabretto, Flavio Faletra, Sheila Ulivi, Fabiola Del Greco M, Maurizio Facheris, Francis S Collins, Richard N Bergman, John P Beilby, Joseph Hung, A William Musk, Massimo Mangino, So-Youn Shin, Nicole Soranzo, Hugh Watkins, Anuj Goel, Anders Hamsten, Pierre Gider, Marisa Loitfelder, Marion Zeginigg, Dena Hernandez, Samer S Najjar, Pau Navarro, Sarah H Wild, Anna Maria Corsi, Andrew Singleton, Eco JC de Geus, Gonneke Willemsen, Alex N Parker, Lynda M Rose, Brendan Buckley, David Stott, Marco Orru, Manuela Uda, LifeLines Cohort Study , Melanie M van der Klauw, Weihua Zhang, Xinzhong Li, James Scott, Yii-Der Ida Chen, Gregory L Burke, Mika Kähönen, Jorma Viikari, Angela Döring, Thomas Meitinger, Gail Davies, John M Starr, Valur Emilsson, Andrew Plump, Jan H Lindeman, Peter AC ‘t Hoen, Inke R König, EchoGen consortium , Janine F Felix, Robert Clarke, Jemma C Hopewell, Halit Ongen, Monique Breteler, Stéphanie Debette, Anita L DeStefano, Myriam Fornage, AortaGen Consortium , Gary F Mitchell, CHARGE Consortium Heart Failure Working Group , Nicholas L Smith, KidneyGen consortium , Hilma Holm, Kari Stefansson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, CKDGen consortium , Cardiogenics consortium , CardioGram , Nilesh J Samani, Michael Preuss, Igor Rudan, Caroline Hayward, Ian J Deary, H-Erich Wichmann, Olli T Raitakari, Walter Palmas, Jaspal S Kooner, Ronald P Stolk, J Wouter Jukema, Alan F Wright, Dorret I Boomsma, Stefania Bandinelli, Ulf B Gyllensten, James F Wilson, Luigi Ferrucci, Reinhold Schmidt, Martin Farrall, Tim D Spector, Lyle J Palmer, Jaakko Tuomilehto, Arne Pfeufer, Paolo Gasparini, David Siscovick, David Altshuler, Ruth JF Loos, Daniela Toniolo, Harold Snieder, Christian Gieger, Pierre Meneton, Nicholas J Wareham, Ben A Oostra, Andres Metspalu, Lenore Launer, Rainer Rettig, David P Strachan, Jacques S Beckmann, Jacqueline CM Witteman, Jeanette Erdmann, Ko Willems van Dijk, Eric Boerwinkle, Michael Boehnke, Paul M Ridker, Marjo-Riitta Jarvelin, Aravinda Chakravarti, Goncalo R Abecasis, Vilmundur Gudnason, Christopher Newton-Cheh, Daniel Levy, Patricia B Munroe, Bruce M Psaty, Mark J Caulfield, Dabeeru C Rao, Martin D Tobin, Paul Elliott, Cornelia M van Duijn 1 Contents Supplementary Figures ........................................................................................................................... 5 Supplementary Tables .......................................................................................................................... 18 Supplementary Note ............................................................................................................................. 52 Phenotype modelling ........................................................................................................................ 52 Selection of SNPs for follow-up in Stage 2 ........................................................................................ 53 Risk score analyses using multi-SNP predictors ................................................................................ 53 Comparison of PP and SBP risk scores .......................................................................................... 54 Functional SNPs in linkage disequilibrium with novel PP and MAP SNPs ......................................... 55 RNA sequence expression analysis ................................................................................................... 55 eQTL analyses.................................................................................................................................... 56 Study Descriptions ............................................................................................................................ 57 AGES Reykjavik .............................................................................................................................. 57 ARIC ............................................................................................................................................... 57 ASPS .............................................................................................................................................. 57 B58C-T1DGC .................................................................................................................................. 58 B58C-WTCCC ................................................................................................................................. 58 BHS ................................................................................................................................................ 58 BLSA .............................................................................................................................................. 58 CHS ................................................................................................................................................ 58 CoLaus ........................................................................................................................................... 59 CROATIA-Korcula ........................................................................................................................... 59 CROATIA-Split ................................................................................................................................ 59 CROATIA-Vis .................................................................................................................................. 59 DGI................................................................................................................................................. 60 EGCUT ........................................................................................................................................... 60 EPIC-Norfolk .................................................................................................................................. 60 ERF................................................................................................................................................. 60 Fenland .......................................................................................................................................... 60 FHS ................................................................................................................................................ 61 FUSION .......................................................................................................................................... 61 InChianti ........................................................................................................................................ 61 INGI CARL ...................................................................................................................................... 62 2 INGI FVG ........................................................................................................................................ 62 INGI Val Borbera ........................................................................................................................... 62 KORA S3 ......................................................................................................................................... 63 KORA F4 ......................................................................................................................................... 63 LBC1921/1936 ............................................................................................................................... 63 LifeLines ........................................................................................................................................ 64 LOLIPOP ........................................................................................................................................
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