The porcine Major Histocompatibility Complex and related paralogous regions: a review Patrick Chardon, Christine Renard, Claire Gaillard, Marcel Vaiman
To cite this version:
Patrick Chardon, Christine Renard, Claire Gaillard, Marcel Vaiman. The porcine Major Histocom- patibility Complex and related paralogous regions: a review. Genetics Selection Evolution, BioMed Central, 2000, 32 (2), pp.109-128. 10.1051/gse:2000101. hal-00894302
HAL Id: hal-00894302 https://hal.archives-ouvertes.fr/hal-00894302 Submitted on 1 Jan 2000
HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Genet. Sel. Evol. 32 (2000) 109–128 109 c INRA, EDP Sciences Review The porcine Major Histocompatibility Complex and related paralogous regions: a review
Patrick CHARDON , Christine RENARD, Claire ROGEL GAILLARD, Marcel VAIMAN Laboratoire de radiobiologie et d’ etude du g enome, D epartement de g en etique animale, Institut national de la recherche agronomique, Commissariat al’ energie atomique, 78352, Jouy-en-Josas Cedex, France (Received 18 November 1999; accepted 17 January 2000)
Abstract – The physical alignment of the entire region of the pig major histocompat- ibility complex (MHC) has been almost completed. In swine, the MHC is called the SLA (swine leukocyte antigen) and most of its class I region has been sequenced. Over one hundred genes have been characterised, including the classical class I and class I-related genes, as well as the class II gene families. These results in swine provide new evidence for the striking conservation during the evolution of a general MHC framework, and are consistent with the location of the class I genes on segments re- ferred to as permissive places within the MHC class I region. Recent results con rm the involvement of the SLA region in numerous quantitative traits. pig / major histocompatibility complex / physical map / performance / paralo- gous regions
R esum e – Le complexe majeur d’histocompatibilit e du porc et les r egions par- alogues. La construction de la carte physique du Complexe Majeur d’Histocompatibi- lit e du porc (SLA) est pratiquement achev ee et la s equence nucl eotidique d’une grande partie de la r egion SLA des g enes de classe I est d’ores et d ej a disponible. Plus de 100 g enes de la r egion dont les di erentes familles de g enes d’histocompatibilit eont et e caract eris es. Les r esultats obtenus chez le porc montrent l’existence d’une trame ancestrale de g enes, conserv ee durant l’ evolution. Ils renforcent l’hypoth ese de la multiplication et di erenciation des g enes de classe I apr es sp eciation et de leur con- nement dans des segments particuliers, d esign es comme permissifs, de la r egion de classe I. Des r esultats r ecents con rment la participation de la r egion SLA dans de multiples caract eres quantitatifs. porc / histocompatibilit e / carte physique / r egions paralogues / caract eres quantitatifs