Borderline Personality Disorder? Understanding the Clinical, Psychopathological, and Sociodemographic Correlates Is Critical
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Bipolar disorder or borderline personality disorder? Understanding the clinical, psychopathological, and sociodemographic correlates is critical Sabrina Correa da Costa, MD* Addiction Psychiatry Fellow lthough evidence suggests that bipolar disorder (BD) and bor- Department of Psychiatry derline personality disorder (BPD) are distinct entities, their Yale University School of Medicine differential diagnosis is often challenging as a result of consid- New Haven, Connecticut A erable overlap of phenotypical features. Moreover, BD and BPD fre- Marsal Sanches, MD, PhD, FAPA Associate Professor quently co-occur, which makes it even more difficult to differentiate Research Track Residency Training Director these 2 conditions. Strategies for improving diagnostic accuracy are crit- Department of Psychiatry and Behavioral Sciences ical to optimizing patients’ clinical outcomes and long-term prognosis. The University of Texas Health Science Center at Houston McGovern Medical School Misdiagnosing these 2 conditions can be particularly deleterious, and Houston, Texas failure to recognize their co-occurrence can result in additional burden Jair C. Soares, MD, PhD to typically complex and severe clinical presentations. Professor & Chairman This article describes key aspects of the differential diagnosis between Pat R. Rutherford, Jr. Chair in Psychiatry Director, Center of Excellence on Mood Disorders BD and BPD, emphasizing core features and major dissimilarities Executive Director UTHealth HCPC between these 2 conditions, and discusses the implications of misdiag- Department of Psychiatry and Behavioral Sciences nosis. The goal is to highlight the clinical and psychopathological aspects The University of Texas Health Science Center at Houston McGovern Medical School of BD and BPD to help clinicians properly distinguish these 2 disorders. Houston, Texas * At the time this article was written, Dr. da Costa was Chief Resident, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas. Psychopathological and sociodemographic correlates Disclosures Bipolar disorder is a chronic and severe mental illness that is classified Dr. Soares receives grant or research support from Compass, based on clusters of symptoms—manic, hypomanic, and depressive.1 It Pathways, Alkermes, Allergan, Merck, and Pfizer, is a consultant to Johnson & Johnson, Myriad, and LivaNova, and is a speaker for is among the 10 leading causes of disability worldwide, with significant 2 Sanofi and Sunovion. Dr. Soares is an Editorial Consultant for CURRENT morbidity arising from acute affective episodes and subacute states. PSYCHIATRY. Drs. da Costa and Sanches report no financial relationships Data suggest the lifetime prevalence of BPD is 2.1%, and subthreshold with any companies whose products are mentioned in this article, or 3 with manufacturers of competing products. forms may affect an additional 2.4% of the US population. The onset of symptoms typically occurs during late adolescence or early adulthood, É and mood lability and cyclothymic temperament are the most common prodromal features.4 continued Current Psychiatry LUDVIK GLAZER-NAUD Vol. 18, No. 11 27 Figure Bipolar disorder and borderline personality disorder: Clinical and sociodemographic correlates Bipolar and related disorders Bipolar disorder 2.1% of the population 1:1.1 female/male ratio or BPD? 10% to 20% mortality from suicide • Episodic course • Gradual changes in mood (days to weeks) • SI/SA in the context of mood symptoms Clinical Point • NSSI less common • Psychotic symptoms only in the presence of mood As a result of the symptoms phenotypical • Family history of mood disorders resemblance between • Interpersonal relationships usually preserved BD and BPD, the differential diagnosis Highly comorbid with: Treatments is often difficult • Anxiety disorders • First-line: Mood stabilizers, SGAs, • ADHD AEDs, and other pharmacologic agents; ECT, rTMS, and other • Substance use disorders somatic treatments (up to 60% comorbid AUD) • Adjunctive: Psychosocial/ behavioral interventions ADHD: attention-deficit/hyperactivity disorder; AEDs: antiepileptic drugs; AUD: alcohol use disorder; ECT: electroconvulsive therapy; NSSI: nonsuicidal self-injury; PTSD: posttraumatic stress disorder; rTMS: repetitive transcranial magnetic stimulation; SGAs: second-generation antipsychotics; SA: suicide attempt; SI: suicidal ideation In contrast, personality disorders, such According to the National Survey on as BPD, are characteristically pervasive Alcohol and Related Conditions (NESARC), and maladaptive patterns of emotional approximately 15% of US adults were found responses that usually deviate from an to have at least one type of personality dis- individual’s stage of development and cul- order, and 6% met criteria for a cluster B tural background.1 These disorders tend personality disorder (antisocial, borderline, to cause significant impairment, particu- narcissistic, and histrionic).7 The lifetime larly in personal, occupational, and social prevalence of BPD is nearly 2%, with higher domains. Environmental factors, such as estimates observed in psychiatric settings.7,8 Discuss this article at early childhood trauma, seem to play an As a result of the phenotypical resem- www.facebook.com/ important role in the genesis of personality blance between BD and BPD (Figure), the MDedgePsychiatry disorders, which may be particularly rel- differential diagnosis is often difficult. Recent evant in BPD, a disorder characterized by studies suggest that co-occurrence of BD and marked impulsivity and a pattern of insta- BPD is common, with rates of comorbid BPD bility in personal relationships, self-image, as high as 29% in BD I and 24% in BD II.8,9 and affect.1,5,6 Similarly to BD, BPD is also On the other hand, nearly 20% of individu- Current Psychiatry 28 November 2019 chronic and highly disabling. als with BPD seem to have comorbid BD.8,9 MDedge.com/psychiatry Borderline personality disorder 1% to 2% of the population 2:1 female/male ratio 8% to 10% mortality from suicide • Pervasive course • Abrupt changes in mood (hours) • SI/SA in the context of psychosocial stressors • NSSI common Clinical Point • Transient psychotic symptoms, usually in the context of stressful situations Evidence suggests • Chaotic interpersonal relationships that BD and BPD • Significant history of trauma have distinct underlying Highly comorbid with: Treatments neurobiological and • Mood disorders • First-line: Psychosocial/behavioral psychopathological • PTSD interventions mechanisms • Substance use • Adjunctive: Pharmacotherapy • Eating disorders ADHD: attention-deficit/hyperactivity disorder; AEDs: antiepileptic drugs; AUD: alcohol use disorder; ECT: electroconvulsive therapy; NSSI: nonsuicidal self-injury; PTSD: posttraumatic stress disorder; rTMS: repetitive transcranial magnetic stimulation; SGAs: second-generation antipsychotics; SA: suicide attempt; SI: suicidal ideation Several studies suggest that comorbid per- Multidimensional approaches have been sonality disorders represent a negative prog- proposed to better characterize these dis- nostic factor in the course of mood disorders, orders in at-risk populations, based on and the presence of BPD in patients with BD structured interviews, self-administered seems to be associated with more severe clini- and clinician-rated clinical scales (Table 1, cal presentations, greater treatment complex- page 35), neuroimaging studies, biological ity, a higher number of depressive episodes, markers, and machine-learning models.15,16 poor inter-episode functioning, and higher Compelling evidence suggests that BD and rates of other comorbidities, such as sub- BPD have distinct underlying neurobiologi- stance use disorders (SUDs).8-11 The effect of cal and psychopathological mechanisms12,13; BD on the course of BPD is unclear and fairly however, the differential diagnosis still unexplored, although it has been suggested relies on phenotypical features, since the that better control of mood symptoms may search for biological markers has not yet lead to more stable psychosocial functioning identified specific biomarkers that can be in BPD.9 used in clinical practice. Whether BD and BPD are part of the Core features of BPD, such as mood labil- Current Psychiatry same spectrum is a matter for debate.12-14 ity, impulsivity, and risk-taking behaviors, Vol. 18, No. 11 29 continued on page 35 continued from page 29 Table 1 Clinical scales used in the differential diagnosis of bipolar disorder and borderline personality disorder MDedge.com/psychiatry Rating scale Description Mood Disorder Questionnaire 15 questions (MDQ) The first 13 questions are designed to identify lifetime manic or hypomanic symptoms; the last 2 questions measure severity and level of functional impairment Hypomania/mania Checklist 2 introductory questions on current emotional state (HCL-32) 32 questions designed to identify manic and hypomanic symptoms Screening Assessment of 3-item scale: Depression-Polarity (SAD-P) • presence of delusions • number of depressive episodes • family history of major depression or mania Bipolar Prodrome Symptom Semi-structured interview developed based on DSM-IV criteria Interview and Scale-Prospective for BD and MDD, clusters of symptoms (mania, depression, and (BPSS-P) general symptom index) Clinical Point The Personality Inventory for 220-item scale assessing 25 personality trait facets, with each trait DSM-5 facet consisting