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SRBR 2010 Program Saturday, May 22, 2010 7:00–9:00 Pm Opening SRBR 2010 Program Saturday, May 22, 2010 7:00–9:00 pm Opening reception Sunday, May 23, 2010 8:30–10:30 am Symposium 1–Transcriptional Regulation of Circadian Clocks Chair: Stacey Harmer, University of California, Davis 8:30 The molecular mechanism of photoadaptation and light entrainment of the Neurospora clock Michael Brunner, Heidelberg University 9:00 Novel approaches for studying circadian transcription in cells and organs Ueli Schibler, University of Geneva 9:30 Molecular mechanism of the drosophila clock Amita Sehgal, HHMI/University of Pennsylvania School of Medicine 10:00 Identification of a new circadian component using data mining Stacey Harmer, University of California, Davis Symposium 2–Circadian Neural Networks Chair: Fernanda Ceriani, Leloir Institute Foundation-Buenos Aires 8:30 CRYPTOCHROME is a cell autonomous neuronal blue light sensor that rapidly regulates neuronal firing rate Todd Holmes, University of California, Irvine 9:00 Accessing neural connectivity in the Drosophila circadian clock network Orie Shafer, University of Michigan 9:30 Complex Electrical States of SCN Neurons Hugh Piggins, University of Manchester 10:00 A parallel circadian system: Making sense of olfactory clocks Erik Herzog, Washington University 10:30–11:00 am Refreshment Break 11:00 am–12:30 pm Slide Session A Chair: Martin Ralph, University of Toronto 11:00 1 • USP2, a de-ubiquitinating enzyme, directly regulates BMAL1 stability and sensitivity to early evening light Heather Scoma, CBNA, Medical College of Wisconsin, Milwaukee, Wisconsin, United States 11:15 2 • The deubiquitinating enzyme USP2 is involved in the regulation of circadian rhythms Adeline Rachalski, Laboratory of Molecular Chronobiology, Douglas Mental Health Institute, Montréal, Canada 11:30 3 • Circadian rhythms in astrocytes depend on intercellular interactions and connexin 43 Luciano Marpegan, Biology, Washington University, St. Louis, Missouri, United States 11:45 4 • Regulation of circadian period by neuronal Agrin and the a3 isoform of Na+/K+-ATPase (ATP1A3) Martin Ralph, Psychology, University of Toronto, Toronto, Canada 12:00 5 • Circadian synaptic plasticity in hypocretin axons is regulated by neuronal pentraxin Lior Appelbaum, Stanford University, Palo Alto, California, United States 12:15 6 • Cell membranes and the Arabidopsis circadian clock Harriet McWatters, University of Oxford, Oxford, United Kingdom Slide Session B Chair: Frank Weber, University of Heidelberg 11:00 7 • Novel small molecules as potent enhancers and modulators of the circadian clock Zheng (Jake) Chen, Biochem & Mol Biol, UT Health Science Center at Houston, Houston, Texas, United States 11:15 8 • Identification and characterization of inhibitors of casein kinase epsilon/delta James Offord, Neuroscience Research Unit, Pfizxer Global Research, Groton, Connecticut, United States 11:30 9 • Therapeutic rescue of disrupted circadian behavior through CK1d inhibition David Bechtold, University of Manchester, Manchester, United Kingdom 11:30 10 • Who's ubiquitinatin' whom: partnering proteasomal machinery with the clock Jason DeBruyne, Pharmacology/ITMAT, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States 11:45 11 • A sequence of specific phosphorylation events controls a core post-translational interval-timer of the Drosophila circadian clock Frank Weber, Biochemistry Center Heidelberg (BZH), University of Heidelberg, Heidelberg, Germany 12:00 12 • PSEUDO-RESPONSE REGULATORS 9 (PRR9), PRR7 and PRR5 are transcriptional repressors in the Arabidopsis circadian clock Norihito Nakamichi, Plant Productivity Systems Research Group, RIKEN Plant Science Center, Yokohama, Japan Slide Session C Chair: Nelson Chong, University of Leicester 11:00 13 • Obesity and metabolic syndrome in mice with an adipose tissue-specific deletion of Bmal1 Georgios Paschos, ITMAT, University of Pennsylvania, Philadelphia, Pennsylvania, United States 11:15 14 • The role of CREM/ICER in circadian events of the liver Damjana Rozman, Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia 11:30 15 • Disruption of peripheral circadian timekeeping in a mouse model of Huntington’s disease and its restoration by temporally scheduled feeding Akhilesh Reddy, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom 11:45 16 • Endogenous circadian rhythm in cardiovascular biomarkers during rest and in reactivity to standardized exercise Frank AJL Scheer, Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States 12:00 17 • Melatonin protects isolated ventricular cardiomyocytes from high glucose induced arrhythmias Nelson Chong, Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom 12:15 18 • Relationship of common polymorphisms in Clock to blood pressure and stroke outcome in man Madhu J. Prasai, Division of Cardiovascular and Diabetes Research, LIGHT Laboratories, University of Leeds, Leeds, United Kingdom 4:00 – 6:00 pm Symposium 3–Circadian Clocks and Sleep Chair: Ravi Allada, Northwestern University 4:30 A cell cycle gene regulates sleep in Drosophila Mike Young and Dragana Rogulja, Rockefeller University 5:00 Clocks and Sleep: Insights of Human Genetics Louis Ptacek, University of California, San Francisco and HHMI 5:30 The Photic Regulation of Sleep Russell Foster, Oxford University 6:00 Sleep timing and duration - genetic and epidemiological aspects Till Roenneberg, Ludwig-Maximilians-Universität München Symposium 4–Entrainment of Clocks Chair: Karl Obrietan, Ohio State University 4:30 Temperature-Controlled Daily Rhythms in Drosophila Herman Wijnen, University of Virginia 5:00 Dual role for ipRGCs in vision and circadian photoentrainment Samer Hattar, Johns Hopkins University 5:30 Intrinsic responses of melanopsin retinal ganglion cells to light Michael Do, Johns Hopkins University 6:00 Food: the main entraining signal for brain and peripheral oscillators Carolina Escobar, Universidad Nacional Autónoma de México Symposium 5–The Transcription/Translational Feedback Model in Eukaryotes and Prokaryotes Chair: Paul Hardin, Texas A&M University 4:30 Post-transcriptional and Post-translational control of the Neurospora circadian clock Yi Liu, UT Southwestern Medical Center 5:00 How coupled oscillators shape the clock in the cell Martha Merrow, University of Groningen 5:30 Post-translational regulation of rhythmic transcription in Drosophila Paul Hardin, Texas A&M University 6:00 The underlying oscillator: Suggestions from cyanobacteria Carl Johnson, Vanderbilt 8:00 – 10:30 pm Poster Session I Monday, May 24, 2010 8:30 – 10:30 am Symposium 6–Seasonal and Reproductive Rhythms Chair: David Hazlerigg, University of Aberdeen 8:30 Circannual rhythms: organismal approaches to elusive periodic timers Barbara Helm, University of Konstanz and Max Planck Institute for Ornithology 9:00 Molecular basis of seasonal time measurement in plants Takato Imaizumi, University of Washington 9:30 Regulation of seasonal body weight in the Siberian hamster Perry Barrett, University of Aberdeen 10:00 Evolutionary dynamics of seasonal rhythms in Drosophila melanogaster Paul Schmidt, University of Pennsylvania Symposium 7–Clocks and the Immune System Chair: Diego Golombek, National University of Quilmes-Buenos Aires 8:30 The circadian control of the adaptive immune response Nicolas Cermakian, McGill University 9:00 Clocks in the immune system Alec Davidson, Morehouse School of Medicine 9:30 Clocks, circadian gates and the inflammatory response Andrew Loudon, University of Manchester 10:00 Ticking clocks and neuroinflammatory signaling Marina Bentivoglio, University of Verona 10:30 – 11:00 am Refreshment Break 11:00 am –12:30 pm Slide Session D Chair: Ruud Buijs, Instituto de Investigaciones Biomedicas 11:00 19 • A role for the dorsomedial hypothalamic nucleus in food anticipatory rhythms in rats Ralph Mistlberger, Psychology, Simon Fraser University, Burnaby, Canada 11:15 20 • The suprachiasmatic nucleus and the dorsomedial nucleus of the hypothalamus are part of a neuronal network that comprises the food entrained oscillator Ruud Buijs, Instituto de Investigaciones Biomedicas, Mexico (DF), Mexico 11:30 21 • Increased food-anticipatory activity in tissue plasminogen activator knockout mice Eric Mintz, Biological Sciences, Kent State University, Kent, Ohio, United States 11:45 22 • Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice Naoto Hayasaka, Anatomy and Neurobiology, Kindai University, Osaka-Sayama, Japan 12:00 23 • Using automated computer vision technology to study anticipatory activity in mouse Andrew Steele, Biology, California Institute of Technology, Pasadena, California, United States 12:15 24 • Chronic methamphetamine controls the phase and organization of peripheral oscillators Jennifer Mohawk, Biology, University of Virginia, Charlottesville, Virginia, United States Slide Session E Chair: Derk-Jan Dijk, University of Surrey 11:00 25 • Physiologic indicators of sleepiness Chern-Pin Chua, Neuroscience & Behavioural Disorders Program, Duke-NUS Graduate Medical School, Singapore, Singapore 11:15 26 • Identification and validation of a candidate gene for wake and REM sleep Karrie Mrazek, Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois, United States 11:30 27 • The PERIOD3 variable number tandem repeat polymorphism and human sleep
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