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Chronic Hyperaldosteronism in Cryptochrome-Null Mice Induces High-Salt- and Blood Pressure- Independent Kidney Damage in Mice
Hypertension Research (2014) 37, 202–209 & 2014 The Japanese Society of Hypertension All rights reserved 0916-9636/14 www.nature.com/hr ORIGINAL ARTICLE Chronic hyperaldosteronism in Cryptochrome-null mice induces high-salt- and blood pressure- independent kidney damage in mice Dwi Aris Agung Nugrahaningsih1, Noriaki Emoto1,2, Nicolas Vignon-Zellweger2, Eko Purnomo1, Keiko Yagi2, Kazuhiko Nakayama1,2, Masao Doi3, Hitoshi Okamura3 and Ken-ichi Hirata1 Although aldosterone has an essential role in controlling electrolyte and body fluid homeostasis, aldosterone also exerts certain pathological effects on the kidney. Several previous studies have attempted to examine these deleterious effects. However, the majority of these studies were performed using various injury models, including high-salt treatment and/or mineralocorticoid administration, by which the kidney changes observed were not only due to aldosterone but also due to prior injury caused by salt and hypertension. In the present study, we investigated aldosterone’s pathological effect on the kidney using a mouse model with a high level of endogenous aldosterone. We used cryptochrome-null (Cry 1, 2 DKO) mice characterized by high aldosterone levels and low plasma renin activity and observed that even under normal salt exposure conditions, these mice showed increased albumin excretion and kidney tubular injury, decreased nephrin expression and increased reactive oxygen species production in the absence of hypertension. Exposure to high salt levels exacerbated the kidney damage observed in these mice. Moreover, we noted that decreasing blood pressure without blocking aldosterone action did not provide beneficial effects to the kidney in high-salt-treated Cry 1, 2 DKO mice. Thus, our findings support the hypothesis that aldosterone has deleterious effects on the kidney independent of high-salt exposure and high blood pressure. -
CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical
CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical Institute Department of Neuroscience University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., NA4.118 Dallas, Texas 75390-9111 (214) 648-1876, FAX (214) 648-1801 Email: [email protected] DATE OF BIRTH: December 16, 1951 NATIONALITY: U.S. Citizen by birth EDUCATION: 1981-1983 Pharmacology Research Associate Training Program, National Institute of General Medical Sciences, Laboratory of Clinical Sciences and Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 1979-1981 Ph.D., Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, Oregon, Dr. Michael Menaker, Advisor. Summer 1977 Hopkins Marine Station, Stanford University, Pacific Grove, California 1975-1979 Department of Zoology, University of Texas, Austin, Texas 1970-1974 B.A. in Biology, Swarthmore College, Swarthmore, Pennsylvania PROFESSIONAL EXPERIENCE: 2013-present Principal Investigator, Satellite, International Institute for Integrative Sleep Medicine, World Premier International Research Center Initiative, University of Tsukuba, Japan 2009-present Professor and Chair, Department of Neuroscience, UT Southwestern Medical Center 2009-present Loyd B. Sands Distinguished Chair in Neuroscience, UT Southwestern 2009-present Investigator, Howard Hughes Medical Institute, UT Southwestern 2009-present Professor Emeritus of Neurobiology and Physiology, and Walter and Mary Elizabeth Glass Professor Emeritus in the Life Sciences, Northwestern University -
Department of Systems Biology
DIVISION OF BIOINFORMATICS AND CHEMICAL GENOMICS Research Profile Department of Systems Biology Professor: Hitoshi Okamura, Associate Professor: Masao Doi, Assistant Professor: Yoshiaki Yamaguchi, Senior Lecturer: Jean-Michel Fustin Research Projects: How TIME is generated and tuned? We will clarify feedback loop of clock genes. the secret of generation and tuning of TIME in 1.3 Clock genes and cell metabolism, birth, and mammalian circadian system by multi-layered view death at intracellular, intercellular and individual levels. Why virtually all cells in the body have the clock Through clarifying the integration network mecha- inside the cell? We will identify how clock genes nism of TIME, we will develop new drugs for tuning work on the energy metabolism, cell cycles, and TIME. cell death. The subject of our study is circadian timing system 2. Intercellular system for synchronizing TIME in mammals. In this system, the circadian TIME gen- 2.1 Region-specific knockdown of SCN erated at molecular clock in the suprachiasmatic SCN biological clock is composed of thousands nucleus (SCN) evokes the synchronized oscillation of clock cells which are subdivided into several of molecular clocks in the whole body. Between groups. We will perform region-specific knockdown them, TIME is transmitted in multilayer systems: 1) of these subdivisions to address the functional sub- intracellular system of generation of cyclic TIME, 2) division of SCN. Intercellular system for synchronizing TIME, and 3) 2.3 Geography of SCN Symphony of TIME in individuals. SCN clock cells are highly organized in time and 1. Clarification of clock machinery to generate space. For example, in our real-time luciferase- TIME imaging system at cell level, time is generated and 1.1 Identification of all components of CLOCK synchronized in a very highly organized system. -
Behavioral Neurobiology Biological Rhythms
Handbook of Behavioral Neurobiology Volume 4 Biological Rhythms HANDBOOK OF BEHAVIORAL NEUROBIOLOGY General Editor: Frederick A. King Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia Editorial Board: Vincent G. Dethier Robert W. Goy David A. Hamburg Peter Marler James L. McGaugh William D. Neff Eliot Stellar Volume 1 Sensory Integration Edited by R. Bruce Masterton Volume 2 Neuropsychology Edited by Michael S. Gazzaniga Volume 3 Social Behavior and Communication Edited by Peter Marler and J. G. Vandenbergh Volume 4 Biological Rhythms Edited by Jiirgen Aschoff Volume 5 Motor Coordination Edited by Arnold L. Towe and Erich S. Luschei A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. Handbook of Behavioral Neurobiology Volume 4 Biological Rhythms Edited by Jiirgen Aschoff Max-Planck Institut fur Verhaltensphysiologie Andechs, German Federal Republic PLENUM PRESS, NEW YORK AND LONDON Library of Congress Cataloging in Publication Data Main entry under title: Biological rhythms. (Handbook of behavioral neurobiology; v. 4) Includes index. 1. Biological rhythms. I. Aschoff, J iirgen. II. Series. QP84.6.B56 591.1'882 80-21037 ISBN 978-1-4615-6554-3 ISBN 978-1-4615-6552-9 (eBook) DOl 10.1007/978-1-4615-6552-9 © 1981 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1981 A Division of Plenum Publishing Corporation -
Profile of Jay C. Dunlap
PROFILE PROFILE Profile of Jay C. Dunlap Paul Gabrielsen Science Writer On moonless nights, the wakes of oceangoing back to oceanography,” Dunlap says, “but I boats sparkle with the blue bioluminescence just thought clocks were the greatest things of unicellular dinoflagellates. As a graduate I’deverheardabout.” He chose to attend student at Harvard University, Jay C. Dunlap Harvard. pondered the carefully orchestrated biological Dunlap found Hastings’ approach to his rhythms that direct dinoflagellates to produce students’ research to be supportive but hands light only at night. Dunlap, a student of off. “He provided all these resources,” Dunlap oceanography at the time, realized that the says, “but he never told people what to do. He field of biological rhythms was still a wide- would give you great feedback on what you open frontier, with many fundamental ques- were doing, but you needed to find your own tions yet to be answered. “This was a place,” way. And if you were lucky enough to do that, he says, “where I could make a mark.” then you really learned how to do science.” Dunlap, Nathan Smith Professor and Chair In 1977, Dunlap attended a 10-week of Genetics at Dartmouth’s Geisel School of summer course on biological rhythms at Medicine and a member of the National Hopkins Marine Station in Pacific Grove, Academy of Sciences since 2009, has devoted California organized by Colin Pittendrigh, his career to answering those fundamental who, along with Hastings, had made pio- questions. His work has uncovered how cir- neering advances in the field of rhythms. The cadian rhythms work at a genetic level, how course attracted scientists studying rhythms environmental cues, such as light, can set bi- along with their graduate students, who, ological clocks, and how the clock can regu- Dunlap says, composed an entire generation Jay C. -
Crystal Structure of the Avirulence Gene Avrlm4-7 of Leptosphaeria Maculans. Illuminates Its Evolutionary and Functional Charact
Crystal structure of the Avirulence Gene AvrLm4-7 of Leptosphaeria maculans. Illuminates its evolutionary and functional characteristics Isabelle Fudal, Francoise Blaise, K Blondeau, M. Graille, A. Labarde, A. Doisy, Bm Tyler, S.D. Kale, Guillaume Daverdin, Marie-Helene Balesdent, et al. To cite this version: Isabelle Fudal, Francoise Blaise, K Blondeau, M. Graille, A. Labarde, et al.. Crystal structure of the Avirulence Gene AvrLm4-7 of Leptosphaeria maculans. Illuminates its evolutionary and functional characteristics. 26. Fungal Genetics Conference at Asilomar, Mar 2011, Asilomar, United States. pp.234. hal-01000740 HAL Id: hal-01000740 https://hal.archives-ouvertes.fr/hal-01000740 Submitted on 6 Jun 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 26th Fungal Genetics Conference at Asilomar March 15-20 2011 Principle Financial Sponsors Genetics Society of America Burroughs Wellcome Fund US National Institutes of Health Novozymes Great Lakes Bioenergy Research Center Konkuk University Bio Molecular Informatics Center Genencor, A Danisco Division -
Abstracts from the Neurospora 2002 Conference
Fungal Genetics Reports Volume 49 Article 13 Abstracts from the Neurospora 2002 conference Neurospora 2002 conference Follow this and additional works at: https://newprairiepress.org/fgr This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License. Recommended Citation Neurospora 2002 conference. (2002) "Abstracts from the Neurospora 2002 conference," Fungal Genetics Reports: Vol. 49, Article 13. https://doi.org/10.4148/1941-4765.1195 This Supplementary Material is brought to you for free and open access by New Prairie Press. It has been accepted for inclusion in Fungal Genetics Reports by an authorized administrator of New Prairie Press. For more information, please contact [email protected]. Abstracts from the Neurospora 2002 conference Abstract Abstracts and Poster abstracts from the Neurospora 2002 conference This supplementary material is available in Fungal Genetics Reports: https://newprairiepress.org/fgr/vol49/iss1/13 : Abstracts from the Neurospora 2002 conference Neurospora 2002 Schedule March 14-17, 2002 Invited Abstracts Asilomar Conference Center Pacific Grove, CA. Poster Abstracts SCIENTIFIC PROGRAM Index Barry Bowman Gloria Turner Schedule of Activities Thursday, March 14 3:00 - 6:00 pm, Registration: Administration 6:00 - 7:00 pm, Dinner: Crocker 7:00 - 10:00 pm, Mixer: Kiln Friday, March 15 7:30 - 8:30 am, Breakfast, Crocker 8:30 - 12:00 Noon, Session I, Chapel Genomic Analysis : Mary Anne Nelson, Chair 8:35 - Bruce Birren, MIT, Whitehead Institute. "Genome sequencing for Neurospora crassa." 9:05 - Gertrud Mannhaupt, Heinrich-Heine-University. "The MIPS Neurospora crassa database- MNCDB." 9:30 - Chuck Staben, U. of Kentucky. "Gene finding and annotation for fungal genomes." 9:55 - Alan Radford, University of Leeds. -
Single-Cell Analysis on the Biological Clock Using Microfluidic
SINGLE-CELL ANALYSIS ON THE BIOLOGICAL CLOCK USING MICROFLUIDIC DROPLETS by ZHAOJIE DENG (Under the Direction of Leidong Mao and Jonathan Arnold) ABSTRACT Single-cell analysis has become crucial for uncovering the underlying mechanism for cell heterogeneity. Different biological questions pose different challenges for single-cell analysis. In order to answer questions like, whether a single-cell has a biological clock and how the clocks synchronize among cells to overcome the heterogeneity, continuous long-term measurement on large numbers of single-cells is required. However traditional measurement techniques usually involve measurement on millions of cells. My dissertation addresses these challenges by developing a microfluidic droplet platform capable of measuring the biological clock on >1000 Neurospora crassa single-cells for up to 10 days. The results show that in Neurospora crassa a single cell has the three major properties of a biological clock: a circadian oscillator, light entertainment, and temperature compensation and that single-cells synchronize their biological clock with each other possibly through quorum sensing. INDEX WORDS: Single-cell analysis, Microfluidic droplets, Neurospora crassa, Circadian rhythm, Biological clock, Stochastic noise, Synchronization SINGLE-CELL ANALYSIS ON THE BIOLOGICAL CLOCK USING MICROFLUIDIC DROPLETS by ZHAOJIE DENG B.A., Huazhong University of Science and Technology, China, 2008 M.S., Huazhong University of Science and Technology, China, 2011 A Dissertation Submitted to the Graduate Faculty -
Challenging the Human Circadian Clock by Daylight Saving Time and Shift-Work
Challenging the human circadian clock by Daylight Saving Time and Shift-Work Academic Dissertation (Doctor rerum naturalium) At the Centre for Chronobiology Institute for Medical Psychology Ludwig-Maximilians-University Munich Written by Thomas Kantermann Born 26th of February, 1979 in Gütersloh Arbeit eingereicht am: 17.07.2008 1. Gutachter / Prüfer: Prof. Gisela Grupe 2. Gutachter / Prüfer: Prof. Benedikt Grothe 3. Prüfer: Prof. Susanne Foitzik 4. Prüfer: Prof. Gerhard Haszprunar Sondergutachter: Prof. Till Roenneberg Tag der mündlichen Prüfung: 15.12.2008 Für meine Schwester Stefanie „Probleme kann man niemals mit derselben Denkweise lösen, durch die sie entstanden sind.“ Albert Einstein dt.-amerikan. Physiker, 1921 Nobelpreis für Physik 1879 – 1955 Contents 1. INTRODUCTION ..................................................................................... 1 1.1. Biological (circa-) Rhythms..........................................................................................2 1.2. Sleep.............................................................................................................................4 1.2.1. Two Process Model of Sleep..................................................................................6 1.2.2. Circadian Rhythm Sleep Disorders, Sleepiness and Fatigue....................................7 1.3. The Internal Clock ........................................................................................................8 1.3.1. Phase of Entrainment – Chronotype .....................................................................11 -
Rhythmic Properties of the Hamster Suprachiasmatic Nucleus in Vivo
The Journal of Neuroscience, December 15, 1998, 18(24):10709–10723 Rhythmic Properties of the Hamster Suprachiasmatic Nucleus In Vivo Shin Yamazaki, Marie C. Kerbeshian, Craig G. Hocker, Gene D. Block, and Michael Menaker National Science Foundation Center for Biological Timing, Department of Biology, University of Virginia, Charlottesville, Virginia 22903 We recorded multiple unit neural activity [multiunit activity between the SCN and other brain areas, and another, with a (MUA)] from inside and outside of the suprachiasmatic nucleus period of ;14 min, was in-phase between the SCN and other (SCN) in freely moving male golden hamsters housed in brain areas. The periods of these ultradian rhythms were not running-wheel cages under both light/dark cycles and constant significantly different in wild-type and tau mutant hamsters. Of darkness. The circadian period of MUA in the SCN matched the particular interest was the unique phase relationship between period of locomotor activity; it was ;24 hr in wild-type and 20 the MUA of the bed nucleus of the stria terminalis (BNST) and hr in homozygous tau mutant hamsters. The peak of MUA in the the SCN; in these two areas both circadian and ultradian com- SCN always occurred in the middle of the day or, in constant ponents were always in-phase. This suggests that the BNST is darkness, the subjective day. There were circadian rhythms of strongly coupled to the SCN and may be one of its major output MUA outside of the SCN in the ventrolateral thalamic nucleus, pathways. In addition to circadian and ultradian rhythms of the caudate putamen, the accumbens nucleus, the medial MUA, neural activity both within and outside the SCN was septum, the lateral septum, the ventromedial hypothalamic acutely affected by locomotor activity. -
HEIDI ELIZABETH HAMM, Ph.D
- 1 - 5/22/2019 CURRICULUM VITAE HEIDI ELIZABETH HAMM, Ph.D. Vanderbilt University Medical Center Professor, Department of Pharmacology 442 Robinson Research Building Nashville, TN 37232-6600 Tel. (615) 343-9536 Fax (615) 343-1084 email: [email protected] DATE AND PLACE OF BIRTH August 26, l950, Loma Linda, California RESEARCH INTERESTS Structure and function of GTP binding proteins Molecular mechanisms of signal transduction Photoreceptors and visual transduction Regulatory mechanisms of GTPases Cellular and molecular neurobiology G protein regulation of secretion Mathematical modeling of signaling networks EDUCATION 1980 - 1983: University of Wisconsin-Madison, Postdoctoral Traineeship (Advisor: M. Deric Bownds, Ph.D.) 1976 - 1980: University of Texas-Austin, Ph.D. Zoology, Feb. l980. (Advisor: Michael Menaker, Ph.D.) 1974 - 1976: University of Florence, Italy, Biology. 1969 - 1973: Atlantic Union College, Lancaster, Massachusetts, B.A., Foreign Language, June, l973. RESEARCH AND PROFESSIONAL EXPERIENCE 2012 – present Aileen M. Lange and Annie Mary Lyle Chair in Cardiovascular Research, Professor of Pharmacology, Vanderbilt University Medical Center. 2000 – 2014 Professor and Chair, Department of Pharmacology, Vanderbilt University Medical Center. Heidi Elizabeth Hamm - 2 - 2000 – 2012 Earl W. Sutherland, Jr., Professor of Pharmacology, Vanderbilt University Medical Center. 2006 – present: Professor, Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center. 2001 – present: Professor, Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center. 1996 - 2000: Professor, Northwestern University Institute for Neuroscience Departments of Molecular Pharmacology and Biological Chemistry and Ophthalmology, Northwestern University School of Medicine. 1994 - 1996: Professor, Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine. 1990 - 1994: Associate Professor, Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine. -
Neurospora 2018 OCTOBER 18-21 ASILOMAR CONFERENCE CENTER
PROGRAM and ABSTRACTS Neurospora 2018 OCTOBER 18-21 ASILOMAR CONFERENCE CENTER PACIFIC GROVE CALIFORNIA Cover design by Stephanie Herzog, Technische Universität Braunschweig Neurospora 2018 October 18-21 Asilomar Conference Center Pacific Grove California Scientific Organizers André Fleißner Thomas M. Hammond Technische Universität Braunschweig Illinois State University Neurospora Policy Committee Barry Bowman Jason E. Stajich Molecular Cell & Developmental Biology Dept. Plant Pathology & Microbiology University of California - Santa Cruz University of California - Riverside André Fleißner Thomas M. Hammond Institut für Genetik School of Biological Sciences Technische Universität Braunschweig Illinois State University Brief Schedule Morning Afternoon Evening Thursday Arrival Dinner October 18 Registration Mixer (Heather) Breakfast Lunch Friday Plenary Session I Plenary Session II Dinner October 19 Cell Biology and Metabolism, Signaling and Poster Session Morphogenesis Development Breakfast Lunch Banquet Saturday Plenary Session III Plenary Session IV Speaker October 20 Gene Expression and Genomics, Evolution, and Poster Session Epigenetics Tools Breakfast Sunday Plenary Session V Lunch October 21 Circadian Clocks and Departure Environmental Sensing All Plenary Sessions will be held in Heather. Posters will be displayed in Heather and Toyon throughout the meeting. They should be set up Friday and displayed until the end of the poster session/reception on Saturday evening. Schedule of Activities Thursday, October 18 15:00 - 18:00 p.m. Registration: