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Tuesday Scientific Session Listing:438–626 TUESDAY SCIENTIFIC SESSION LISTING:438–626 Washington, DC Nov. 11–15 Complete Session Listing Tuesday AM LECTURE Walter E. Washington Convention Center SYMPOSIUM Walter E. Washington Convention Center 438. Bridge Over Troubled Synapses: C1q Proteins, Glud 440. Exciting New Tools and Technologies Emerging From Receptors, and Beyond — CME the BRAIN Initiative — CME Tue. 8:30 AM - 9:40 AM — Hall D Tue. 8:30 AM - 11:00 AM — Ballroom C Speaker: M. YUZAKI, Keio Univ. Sch. of Med. Chair: J. A. GORDON The C1q complement family has emerged as a new class The BRAIN Initiative seeks to reveal how brain cells and of synaptic organizers. C1q is shown to regulate synapse circuits dynamically interact in time and space to shape elimination. In the cerebellum, Cbln1 binds to its pre- and our perceptions and behavior. BRAIN investigators are postsynaptic receptors neurexin (Nrx) and the δ2 glutamate accelerating the development and application of new tools receptor (GluD2), respectively. The Nrx/Cbln1/GluD2 and neurotechnologies to tackle these challenges. This tripartite complex across the synaptic gap is essential not symposium highlights advances that will enable exploration only for synapse formation, but also for synaptic plasticity. of how the brain records, stores, and processes vast Similar mechanisms are beginning to be revealed for amounts of information, shedding light on the complex links other Cbln- and C1q-like proteins in various circuits in the between brain function and behavior. forebrain. 8:30 440.01 Introduction. 8:35 440.02 High density carbon fiber electrode array for the SYMPOSIUM Walter E. Washington Convention Center detection of electrophysiological and dopaminergic activity. C. A. CHESTEK. Univ. of Michigan. 439. Tau Homeostasis and Toxicity in Neurodegeneration — CME 9:10 440.03 Multi-scale, multi-modal imaging of spontaneous activity in mice. M. C. CRAIR. Yale Univ. Tue. 8:30 AM - 11:00 AM — Ballroom A AM Tues. 9:45 440.04 Magnetic nanotransducers for wireless neural Chair: L. GAN excitation. P. ANIKEEVA. MIT. Co-Chair: K. ASHE 10:20 440.05 Sonogentics: A non-invasive method for Microtubule-binding protein tau has emerged as a central manipulating neurons. S. CHALASANI. The Salk Inst. For player in neurodegenerative diseases. Imbalanced tau Biol. Studies. proteostasis, characterized with accumulation and spread, is linked with neuronal and synaptic toxicity. The aim of the 10:55 440.06 Closing Remarks. symposium is to discuss how tau proteostasis becomes dysregulated and how tau becomes toxic. The symposium will focus on the post-translational mechanisms, as well MINISYMPOSIUM Walter E. Washington Convention Center as cell autonomous and non-cell autonomous forms of regulation in both animal models and human stem cells. 441. Glia-Neuron Interactions Regulate Sleep — CME 8:30 439.01 Introduction. Tue. 8:30 AM - 11:00 AM — Ballroom B 8:35 439.02 ● Tau lifespan in neurodegenerative diseases. B. T. Chair: P. J. SHIROMANI HYMAN. Massachusetts Gen. Hosp. Co-Chair: M. FRANK 9:10 439.03 ● Insights into regulation of tau proteostasis in Current models of sleep-wake regulation are neuron- human stem cell models of dementia. R. LIVESEY. Univ. of centric and cannot explain key aspects of sleep. This Cambridge. minisymposium will present research showing that sleep network models need to be revised to include glia. The 9:45 439.04 Caspase-2 cleavage of tau reversibly impairs session will present new evidence gathered using innovative memory. K. H. ASHE. Univ. of Minnesota. methods that prove a glial-neuron network modulates sleep 10:20 439.05 Critical role of tau acetylation in tau homeostasis architecture and homeostatic sleep drive. This also explains and toxicity. L. GAN. Gladstone Institutes, UCSF. why sleep is necessary, a topic of interest to everyone. 10:55 439.06 Closing Remarks. 8:30 441.01 Introduction. 8:35 441.02 Optogenetic activation of astroglia induce sleep in mice. C. A. BLANCO-CENTURION. Med. Univ. of South Carolina. 8:55 441.03 Wakefulness stimulates D-serine release from astrocytes. P. G. HAYDON. Tufts Univ. Sch. of Med. 9:15 441.04 Conserved glial mechanisms in sleep architecture and regulation. M. FRANK. Washington State University, Spokane. 9:35 441.05 Glial adenosine acts on A1 receptors to regulate sleep drive. R. W. GREENE. UTSW & VAMC. • Indicated a real or perceived conflict of interest, see page 149 for details. Indicates a high school or undergraduate student presenter. Neuroscience 2017 | Tuesday AM | 1 * Indicates abstract’s submitting author 9:55 441.06 Activation of the glymphatic system during sleep: A 8:55 443.03 Auditory-tactile interactions in mouse function of sleep. M. NEDERGAARD. Univ. Rochester. somatosensory cortex. D. H. O’CONNOR. The Johns Hopkins Univ. Sch. of Med. 10:15 441.07 Sleep loss induces structural changes in astrocytes. M. BELLESI. Univ. of Wisconsin-Madison. 9:15 443.04 Where and how in the cerebral cortex do single neurons process more than one sensory modality during 10:35 441.08 Closing Remarks. perceptual judgments? J. VERGARA. Inst. de Fisiología Celular, Natl. Autonomous Univ. of Mexico & El Colegio Nacional. MINISYMPOSIUM Walter E. Washington Convention Center 9:35 443.05 The role of the beta rhythm in supramodal 442. The Structure and Function of Specific Cell-Cell information processing. S. HAEGENS. Columbia Univ. Col. Interactions in Neural Development: Protocadherins and of Physicians and Surgeons. Atypical Cadherins — CME 9:55 443.06 Neural correlates of auditory-tactile integration in Tue. 8:30 AM - 11:00 AM — 145B meter perception. J. HUANG. Johns Hopkins Univ. Chair: J. D. JONTES 10:15 443.07 Distributed representations of auditory and tactile Co-Chair: J. A. WEINER frequency in the human brain. J. M. YAU. Baylor Col. of Med. Cell-cell interactions control nearly every process 10:35 443.08 Closing Remarks. underlying neural circuit assembly. Protocadherins and atypical cadherins comprise a large and diverse group of molecules within the cadherin superfamily that mediate MINISYMPOSIUM Walter E. Washington Convention Center intercellular interactions in a broad range of developmental contexts. This minisymposium will explore recent advances 444. Functional Diversity of Prefrontal Cortical Regions and in understanding the structure, function, and disease- Networks — CME associated disruption of these diverse cell-surface proteins. Tue. 8:30 AM - 11:00 AM — 151B 8:30 442.01 Introduction. Chair: D. E. MOORMAN 8:35 442.02 The outs and ins of protocadherins in dendrite Co-Chair: S. HEILBRONNER arborization. J. A. WEINER. The Univ. of Iowa. The prefrontal cortex (PFC) is a complex structure that plays 8:55 442.03 Dscam masks adhesion mediated by classical diverse roles in cognition and emotion and is disrupted in cadherins and protocadherins. A. M. GARRETT. The multiple diseases. Despite decades of research into rodent Jackson Lab. PFC, there is no formal model of how its heterogeneous anatomy predicts its multifaceted role in behavior and 9:15 442.04 The role of d-protocadherins in the assembly of disease. This minisymposium will present recent research functional neural networks. J. D. JONTES. Ohio State Univ. using a range of modern techniques to advance new 9:35 442.05 The ins and outs of Fat3-dependent neuronal perspectives on the intersection between structure and morphogenesis. L. V. GOODRICH. Harvard Med. Sch. function in medial and orbital PFC networks. 9:55 442.06 Sound perception and brain wiring enabled by 8:30 444.01 Introduction. exceptional cadherins. M. SOTOMAYOR. Ohio State Univ. 8:35 444.02 Connectivity reveals PFC homologies across 10:15 442.07 Molecular logic of neuronal self-avoidance through rodents and nonhuman primates. S. R. HEILBRONNER. protocadherin interactions. R. RUBINSTEIN. Columbia Univ. Univ. of Rochester. 10:35 442.08 Closing Remarks. 8:55 444.03 Functional heterogeneity in the rat prefrontal cortex supports correctly timed responses. I. DIESTER. Albert Ludwigs Univ. Freiburg. MINISYMPOSIUM Walter E. Washington Convention Center 9:15 444.04 Prefrontal cortical encoding of valence and action. D. E. MOORMAN. Univ. of Massachusetts Amherst. 443. Good Vibrations: Genetic, Neural, and Behavioral Links Between Auditory and Tactile Perception — CME 9:35 444.05 Toggling between actions and habits: Involvement of the orbitofrontal cortex. S. L. GOURLEY. Emory Univ. Tue. 8:30 AM - 11:00 AM — 146A 9:55 444.06 Time-dependent regulation of fear memories: Chair: J. M. YAU Focus on prefrontal cortical circuits. F. H. DO MONTE. The Co-Chair: S. HAEGENS Univ. of Texas Hlth. Sci. Ctr. While the neural systems underlying perception have been 10:15 444.07 The infralimbic cortex: What does it actually do well-studied, it remains debatable whether our senses rely during cocaine-seeking behavior? R. T. LALUMIERE. Univ. on supramodal mechanisms. Recent evidence suggests of Iowa. that circuits traditionally considered modality-dedicated may support multiple senses. This minisymposium addresses 10:35 444.08 Closing Remarks. the relationship between audition and touch — senses that signal by mechanotransduction. The speakers will consider cross-species evidence for links between audition and touch spanning genetics, neurophysiology, and behavior. 8:30 443.01 Introduction. 8:35 443.02 Do common genes govern tactile and auditory performance? G. LEWIN. Max-Delbrück Ctr. for Mol. Med. (MDC). 2 | Society for Neuroscience • Indicated a real or perceived conflict of interest, see page 149 for details. Indicates a high school or undergraduate student presenter. * Indicates abstract’s submitting author BASIC-TRANSLATIONAL-CLINICAL ROUNDTABLE Walter E. NANOSYMPOSIUM Washington Convention Center 448. Neuronal Differentiation Mechanisms 445. ● Advances and Challenges in Deep Brain Stimulation — CME Theme A: Development Tue. 8:00 AM – Walter E. Washington Convention Tue. 8:30 AM - 11:00 AM — 206 Center, 156 Organizer: A. M. LOZANO 8:00 448.01 A systems level view on miR-124 function Speakers: P. BROWN, C. C. McINTYRE, P. L. STRICK during neuronal differentiation from human iPS cells. L.
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