In Vitro Fertilization: Four Decades of Reflections and Promises
Biochimica et Biophysica Acta 1810 (2011) 843–852 Contents lists available at ScienceDirect Biochimica et Biophysica Acta journal homepage: www.elsevier.com/locate/bbagen In vitro fertilization: Four decades of reflections and promises Yulian Zhao a,⁎, Paul Brezina a, Chao-Chin Hsu b, Jairo Garcia a, Peter R. Brinsden c, Edward Wallach a a Department of Gyn/Ob, Johns Hopkins University School of Medicine, Johns Hopkins at Green Spring Station, Lutherville, MD 21093, USA b Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, Taiwan c Bourn Hall Clinic, Cambridge, UK article info abstract Article history: Background: In 2010, Robert Edwards was awarded the Nobel Prize in Medicine for his pioneering work in the Received 21 March 2011 development of in vitro fertilization, a field that has touched millions of lives across the globe. Edwards Received in revised form 3 May 2011 dedicated his career to helping couples overcome infertility. He first established principles of early embryo Accepted 4 May 2011 development that served as the foundation for his later work. In the 1960s, he achieved the first human Available online 13 May 2011 fertilized oocyte in vitro while at the Johns Hopkins Hospital. He then continued his work at Cambridge University. In 1978, the world witnessed the birth of the first “test tube baby”. This achievement is a landmark Keywords: not only in the reproductive sciences but also in the history of mankind's technological evolution. Nobel Prize fi Robert Edwards Scope of review: This article outlines the development and progression of IVF from its infancy to the re ned In vitro fertilization and broadly utilized technology offered to patients today.
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