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Cerebral astroblastoma: A radiopathological diagnosis http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040033/?report=printable

J Pediatr Neurosci. 2014 Jan-Apr; 9(1): 45–47. PMCID: PMC4040033 doi: 10.4103/1817-1745.131485

Cerebral astroblastoma: A radiopathological diagnosis

Deepak Kumar Singh , Neha Singh ,1 Ragini Singh , 1 and Nuzhat Husain 2

Department of Neurosurgery, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India 1 Department of Radiodiagnosis, King George's Medical University, Lucknow, Uttar Pradesh, India 2 Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India Address for correspondence: Dr. Deepak Kumar Singh, Department of Neurosurgery, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow - 226 010, Uttar Pradesh, India. E-mail: [email protected]

Copyright : © Journal of Pediatric Neurosciences

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract Astroblastoma is a rare glial whose histogenesis has been clarified recently. It primarily occurs in children and young adults. We are reporting a case of 12-year-old girl child who presented with features of raised intracranial tension and generalized tonic-clonic seizures. Brain magnetic resonance imaging revealed a large well-circumscribed, cystic lesion without perifocal edema, and enhancing mural nodule in right parietal region. A radiological differential diagnosis of pilocytic and cerebral astroblastoma was made. A complete excision was done and histologically the lesion turned out to be an astroblastoma. We review the histology, immunohistochemistry, and imaging features of astroblastoma and survey the current literature, treatment strategies, and prognostic aspects for the management of this rare neoplasm.

Keywords: Astroblastoma, , cystic tumor, glial tumor

Introduction Astroblastomas are uncommon of uncertain origin, constituting 0.45%-2.8% of all neuroglial tumors. These lesions are prone for misdiagnosis as they share radiopathologic features with other neuroglial tumors and their rare occurrence in clinical practice. This article

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describes the case of a young girl with a large supratentorial cerebral astroblastoma with its clinical, radiological, and pathological features.

Case Report A 12-year-old girl child presented with episodes of generalized tonic-clonic seizures for 6 months and headache and episodic vomiting for 2 months. Neurological examination did not reveal any significant abnormality. Bilateral papilledema was detected on fundoscopy. Routine blood and biochemical investigations were within normal limits. Brain magnetic resonance imaging (MRI) revealed a large well-defined predominantly cystic lesion without perilesional edema in right parietal region extending from cortex to periventricular region with mass effect in form of effacement of overlying cortical sulci, ipsilateral sylvian fissure, and lateral ventricle with significant midline shift towards left. The lesion was hyper intense on T2 fluid-attenuated inversion recovery (FLAIR), T2- and T1-weighted images (WI). Foci blooming on gradient recoiled echo images were noted at the periphery of lesion suggestive of calcifications. Gadolinium administration demonstrated peripheral enhancement of the lesion with strongly enhancing mural nodule [ Figure 1 ] Based on these findings, differential diagnosis of and cerebral astroblastoma were made.

The patient was operated under general anaesthesia. A right parietal craniotomy was made and gross total excision of tumor was achieved. The tumor was largely cystic with small soft, vascular, and suckable solid component. The tumor was well-demarcated from the surrounding brain without any areas of hemorrhage or necrosis.

Patient made an uneventful recovery in the postoperative period and there was no additional neurological deficit.

Histopathological examination of tumor tissue revealed perivascular arrangement of cells with short stout cytoplasmic processes anchored to blood vessel walls (pseudorosettes) without any evidence of necrosis, mitosis, or vascular proliferation. Tumor cells were spindle shaped having moderately eosinophilic cytoplasm and eccentrically placed nuclei with strong immunopositivity to glial fibrillary acidic protein (GFAP), , and S-100 [ Figure 2 ]. Based on these findings, a histopathological diagnosis of low-grade cerebral astroblastoma was made and patient was referred for adjuvant radiotherapy.

Discussion Astroblastoma is a rare tumor of glial origin that occurs most frequently in older children or young adults. These lesions were first described by Bailey and Cushing[ 1] in 1926, and their statistical analysis was supported by Bailey and Bucy in 1930.[ 2] These tumors are classified as neuroepithelial tumors; however, lack of sufficient clinicopathological data thwarts the World Health Organization (WHO) grading of these tumors.[ 3,4] The cell of origin of astroblastoma is still arguable but broadly accepted to be the astroblast − an intermediate cell between spongioblast and .[ 2] Yao et al .,[ 5] has recently published a case of 36-year-old man with astroblastoma-arteriovenous malformation complex at same location and concluded the possibility that the vascular needs for astroblastoma growth were most likely partly supplied by the arteriovenous malformation (AVM) and that their concurrent finding in the same location in the brain was probably determined by a

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common genetic and molecular basis.

The studies performed till date show striking female preponderance with a male to female ratio of 1:11.[ 6] Most commonly patients present with features of raised intracranial tension, drowsiness, and seizures.

Astroblastomas are usually supratentorial neoplasms; however, these have been rarely reported in infratentorial locations like , , and extracranial sites like and cauda equina nerve roots.[ 7,8] In cerebral hemispheres, occipital and frontal lobes are the most frequently affected sites.

Radiologically, they are well-demarcated solid cystic lesions with “bubbly" appearance which results from the angioarchitecture of tumor causing signal voids on MRI. Astroblastomas typically extend from cortex to periventricular region with absent or mild perilesional edema as compared with their potentially large size, suggesting absence of local infiltration in the surrounding brain parenchyma. The lesions are hyperintense to white matter on fast FLAIR and T2-weighted images and hypo- to isointense on T1-weighted images. It shows heterogeneous and rim enhancements on contrast-enhanced T1-weighted images. Calcifications are common findings seen in most of the reported cases.[ 6]

Major radiological differential diagnosis of astroblastoma is , astrocytoma, and . can be differentiated by their predilection for infratentorial intraventricular or periventricular locations. If located supratentorially, moderate perilesional edema is usually seen and the solid component lacks the characteristic “bubbly” appearance seen with astroblastoma.[ 9] and are associated with marked perilesional edema and cystic appearance is caused by central necrosis. are rare tumors that may appear bubbly due to foci of cystic degeneration but 70%-90% of these lesions show nodular or clumped calcifications, in distinction to the punctate calcifications seen in astroblastoma.

Imaging of our case shows a large cystic lesion with peripheral punctate calcifications and enhancing mural nodule, extending from cortex to periventricular region so differential diagnosis of pilocytic astrocytoma and astroblastoma were kept.

The histological hallmark of astroblastoma, as described by Bailey and Bucy[ 2] is perivascular arrangement of neoplastic cells having thick and short cytoplasmic processes with peripheral nuclei, forming a pseudorosette giving the characteristic “cartwheel” appearance. Other features of diagnostic importance are lack of fibrillary background, variable number of hyalinized vessels, and compressive rather than infiltrative margin. Perivascular pseudorosettes can also be seen in glioblastoma, anaplastic astrocytoma, and ependymomas. These changes are usually focal in first two differentials but diffuse in astroblastomas. Ependymomas can be differentiated on the basis of compact perivascular arrangement of cells with thin cytoplasmic processes compared with thick and blunt processes in astroblastomas cells.[ 10 ]

Astroblastomas show strong immunopositivity for GFAP, S-100 protein, and vimentin. Bonnin and Rubinstein[ 11 ] categorized these tumors into low-grade and high-grade astroblastomas. Low-grade astroblastoma were characterized as well-differentiated tumor with perivascular pattern, little cellular atypia, low to moderate mitotic figures, and prominent sclerosis of the vascular walls. These lesions have an indolent

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course and patients may have long-term survival after total resection. High-grade astroblastomas had anaplastic features, high cellularity, cytological atypia, a high mitotic rate and endothelial hyperplasia without sclerosis of the vessel walls. These tumors are more aggressive and can transform into glioblastoma-like tumors. Histological features in our case were consistent with low-grade astroblastoma.

The ideal management of astroblastoma remains to be defined. Favorable prognosis is almost always associated with well-circumscribed tumors, which permits total resection.[ 12 ] Given the peripheral location of astroblastomas, total resection seems a goal easier to achieve than in other . Close follow-up of all cases and adjuvant therapy for high grade and recurrent cases is recommended.[ 11 ] In low-grade astroblastomas radical surgery may be the only necessary treatment, though we have given adjuvant radiation in view of nonstandardization and reports of early recurrence even after radiologically complete excision.[ 13 ] The lack of enough information about the natural history favors the use of adjuvant radiotherapy from the beginning.

Ahmed et al .,[ 14 ] have recently published the largest series of 239 patients and concluded that supratentorial location, age >60 years at diagnosis and treatment before 1990 were correlated with decreased survival.

However, continued clinical studies and longer patient follow-up with a tumor-based registry would further clarify the real behavior of astroblastoma and its optimal management.

Footnotes

Source of Support: Nil

Conflict of Interest: None declared.

References 1. Bailey P, Cushing H. Philadelphia: J.B. Lippincott Company; 1926. A classification of the tumors of the group on a histogenetic basis with a correlated study of prognosis; pp. 134–67.

2. Bailey P, Bucy PC. Astroblastomas of the brain. Acta Psychiatr Neurol. 1930;5:439–61.

3. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the . Acta Neuropathol. 2007;114:97–109. [PMCID: PMC1929165] [PubMed: 17618441]

4. Salvati M, D’Elia A, Brogna C, Frati A, Antonelli M, Giangaspero F, et al. Cerebral astroblastoma: Analysis of six cases and critical review of treatment options. J Neurooncol. 2009;93:369–78. [PubMed: 19214707]

5. Yao K, Li TF, Zhu MW, Duan ZJ, Liu CQ, Wang JQ, et al. Mixed astroblastoma-arteriovenous malformation complex: A case report. Neurol India. 2013;61:439–42. [PubMed: 24005749]

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6. Bell JW, Osborn AG, Salzman KL, Blaser SI, Jones BV, Chin SS. Neuroradiologic characteristics of astroblastoma. Neuroradiology. 2007;49:203–9. [PubMed: 17216265]

7. Grotts BF. Astroblastoma of the cerebellum in an infant; report of a case. Arch Pediatr. 1949;66:283–8. [PubMed: 18134318]

8. Notarianni C, Akin M, Fowler M, Nanda A. Brainstem astroblastoma: A case report and review of the literature. Surg Neurol. 2008;69:201–5. [PubMed: 17765957]

9. Furie DM, Provenzale JM. Supratentorial ependymomas and : CT and MR appearance. J Comput Assist Tomogr. 1995;9:518–26. [PubMed: 7622676]

10. Port JD, Brad DJ, Burger PC, Pomper M. Astroblastoma: Radiologic-pathologic correlation and distinction from Ependymoma. Am J Neuroradiol. 2002;23:243–7. [PubMed: 11847049]

11. Bonnin JM, Rubinstein LJ. Astroblastomas: A pathological study of 23 tumors, with a postoperative follow-up in 13 patients. Neurosurgery. 1989;25:6–13. [PubMed: 2755581]

12. Caroli E, Salvati M, Esposito V, Orlando ER, Giangaspero F. Cerebral astroblastoma. Acta Neurochir (Wien) 2004;146:629–33. [PubMed: 15168232]

13. Cabello A, Madero S, Castresana A, Diaz-Lobato R. Astroblastoma: Electron microscopy and immunohistochemical findings: Case report. Surg Neurol. 1991;35:116–21. [PubMed: 1990478]

14. Ahmed KA, Allen PK, Mahajan A, Brown PD, Ghia AJ. Astroblastomas: A SEER Based Patterns of Care Analysis. World Neurosurg. 2013

Figures and Tables

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Figure 1

Magnetic resonance imaging brain axial T2 fluid-attenuated inversion recovery (a), T1WI (c) and coronal T2WI (b) shows a well-defined hyperintense cystic lesion with few thin peripheral septation and mural nodule in right parietal region causing mass effect with midline shift to left. Note, the characteristic absence of perilesional edema. Coronal contrastenhanced T1WI (d) shows enhancement of the cyst wall (arrow heads) and mural nodule (arrow)

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Figure 2

Histopathological examination showing (a) Perivascular arrangement of tumor cells with short stout cytoplasmic processes anchored to blood vessel walls (H and E × 100) with strong immunopositivity to glial fibrillary acidic protein (b), vimentin (c), and S-100 (d)

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