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MEDICC Review July–October 2021 Vol 23, No 3–4 More Accurately Estimating Iron-Deficiency Anemia in 37 Cuban Children Improving Diagnosis of Ketosis-Prone Type 2 Diabetes in Africa 61 Potential of Enhanced Recovery Protocols 46 for Cardiac Surgery Another Cuban Monoclonal Antibody for Non-Small Cell Lung Cancer? 21 Comparing Responses in Rwanda, South Africa 15 & Zimbabwe Vaccines: Cuba’s National Regulatory Authority 9 Managing Hypoxemia to Prevent Cytokine Storms 54 Are Other Zoonoses Spreading During 8 the Pandemic? Peer reviewed since 2007 www.mediccreview.org Editor-in-Chief C. William Keck MD MPH FACPM Executive Editor Gail Reed MS Senior Editor, English Edition Caitlin Baird PhD Senior Editor Conner Gorry MA July–October 2021, Vol 23, No 3–4 Primary Issue Coordinator Jorge Bacallao PhD DSc EDITORIAL Issue Coordinators Alina Alerm MD MS 4 US Sanctions on Cuba Further Imperil Global Vaccine Equity Lila Castellanos PhD DSc Gisele Coutin MD MS ABOUT THE CONTRIBUTORS Esther María Fajardo MS 7 Editorial Associates Tania L. Aguilar MD MS Anna Kovac LETTERS Annet Sánchez 8 At Least One Zoonosis Silently Spreads During COVID-19: Brucellosis Guillermo Antonio Barreto-Argilagos PhD Copy Editor and Herlinda de la Caridad Rodríguez-Torrens DVM MS Carolyn Gorry Communications Consultant CUBA'S WOMEN OF SCIENCE Elizabeth Sayre MA 9 Cuba’s National Regulatory Authority & COVID-19: Publishing & Circulation Olga Lidia Jacobo-Casanueva MS Aram Álvarez MFA Director, Center for State Control of Medicines and Medical Devices (CECMED) Silvia García Tania L. Aguilar-Guerra MD MS, et al. Yenny Leal Translators POLICY & PRATICE Pamela Boyle 15 COVID-19: Comparison of the Response in Rwanda, South Africa and Zimbabwe MEDICC Review is indexed in: Tafadzwa Dzinamarira MPH PhD, et al. MEDLINE®/PubMed® ORIGINAL RESEARCH 21 Racotumomab in Non-Small Cell Lung Cancer as Maintenance and Second-Line Treatment Haslen H. Cáceres-Lavernia MD MS, et al. 29 Subtype-Dependent Co-receptor Tropism in Cuban HIV-1–Infected Patients: Implications for Maraviroc Treatment Global Health Tropical Diseases Bulletin Yenisleidys Martínez-Montesino MS, et al. ELSEVIER EMBASE EBSCO TM 37 Infl uence of Infl ammation on Assessing Iron-Defi ciency Anemia SCOPUS in Cuban Preschool Children Gisela M. Pita-Rodríguez MD MS, et al. REVIEW ARTICLE 46 Improved Recovery Protocols in Cardiac Surgery: MEDICC Review is a unique open-access platform for A Systematic Review and Meta-Analysis of Observational Latin American and Caribbean praxis addressing today’s and Quasi-Experimental Studies critical interactions between human health, development of sustainable societies, and the health of our planet. Draw- María O. Agüero-Martínez MD MS PhD, et al. ing upon the contributions of the region in social medicine, social movements, rich diversity and scientifi c prowess, Latin America and Caribbean authors published in the PERSPECTIVE journal can help fi ll gaps in thinking and evidence sorely 54 Hypoxemia and Cytokine Storm in COVID-19: Clinical Implications needed to build a sustainable future and a hopeful legacy Calixto Machado-Curbelo MD PhD FAAN and Alina González-Quevedo MD PhD for future generations. We look forward to contributing to increased visibility for their work and to its positive impact on both regional integration and worldwide solutions. VIEWPOINT MEDICC Review is published by MEDICC, a US nonprofi t 61 Improving Ketosis-Prone Type 2 Diabetes Diagnosis in Africa organization founded in 1997, based in Oakland, Califor- Dagoberto Álvarez-Aldana MD MS nia, USA, and dedicated to US, Cuban and global health cooperation and equity. 63 Unnecessary Referrals to Pediatric Immunology Services MEDICC Review online (ISSN 1527-3172) is an open- Jesús S. Burón-Hernández MD access publication: see our Creative Commons License online for details. www.mediccreview.org – Copyright © 2021, MEDICC Review July–October 2021, Vol 23, No 3–4 REPRINT 65 A Year in the COVID-19 Epidemic: Cuba and Uruguay in the Latin American Context Luis Carlos Silva-Ayçaguer and Jacqueline Ponzo-Gómez Translated from the Spanish and reprinted with permission from the Revista Cubana de Higiene y Epidemiología, Vol 59, 2021, ID 1063 KEYNOTES 74 Open Letter to President Biden about COVID Vaccines for Cuba Document presented by BioCubaFarma Scientists in Havana on August 10, 2021 ABSTRACTS Cuban Research in Current International Journals Special Abstracts Section COVID-19 Cover photo credits, left to right: Top row (www.cubadebate.cu, www.minrex.gob.cu/es) Middle row (www.granma.cu, www.cubadebate.cu) Bottom row (www.radiococo.icrt.cu, www.cubadebate.cu) AAvailablevailable onlineonline onlyonly https://doi.org/10.37757/MR2021.V23.N3 MEDICC Review Editorial Board Neil Arya BASc MD CCFP FCFP Tee L. Guidotti MD MPH DABT André-Jacques Neusy MD DTM&H Director, Offi ce of Global Health Consultant, Occupational & Environmental Health Senior Director, Training for Health Equity Network Schulich School of Medicine and Dentistry and Medicine, Toronto, Canada THEnet, USA Western University, Canada Jean Handy PhD F. Javier Nieto MD PhD Rifat Atun MBBS MBA FRCGP FFPH FRCP Associate Professor of Microbiology & Immunology Dean, College of Public Health & Human Sciences Professor of Global Health Systems University of North Carolina School of Medicine, USA Oregon State University, USA Director, Health Systems Cluster Harvard University School of Public Health, USA Barbara J. Hatcher PhD MPH RN FAAN Peter Orris MD MPH Associate Professor, George Mason University Professor and Chief, Occupational & Environmental Michael Bird MSW MPH College of Nursing & Health Sciences, USA Public Health Consultant, Kewa Pueblo Health Board Medicine, University of Illinois Hospital and Health Sciences System, USA Urban Indian Health Commission Raúl Herrera MD PhD DSc Albuquerque, New Mexico, USA Distinguished Professor, Medical University of Havana; Chair, National Nephrology Group, Cuba Jorge Pérez MD MS James Boex PhD MBA Adviser to the Director and Full Professor Pedro Kourí Tropical Medicine Institute, Cuba Emeritus Professor of Medical Education Eve J. Higginbotham SM MD University of Cincinnati College of Medicine, USA Vice Dean of Diversity & Inclusion, University of Pennsylvania Perelmen School of Medicine, USA Patricia Rodney RN MPH PhD Peter Bourne MD MA Partners in Health, Education and Development, USA Visiting Senior Research Fellow Sharon K. Hull MD MPH Green Templeton College, University of Oxford, UK Founder and CEO María Isabel Rodríguez MD Metta Solutions, USA Health and Education Advisor to the President of the Alfred Brann MD Republic, El Salvador Professor of Pediatrics C. William Keck MD MPH FACPM Emory University School of Medicine, USA Professor Emeritus, Family and Community F. Douglas Scutchfi eld MD FACPM FAAP Medicine, Northeast Ohio Medical University, USA Peter P. Bosomworth Professor of Health Services Jaime Breilh MD MSc PhD Research and Policy, University of Kentucky Director, Health Department Ann Marie Kimball MD MPH FACPM Colleges of Public Health and Medicine, USA Universidad Andina Simón Bolívar, Ecuador Senior Consulting Fellow, Chatham House Royal Institute of Foreign Affairs; Strategic Consultant in Paulo M. Buss MD MPH Global Health, Rockefeller Foundation, USA Stuart G. Shanker DPhil MA Director, FIOCRUZ Center for Global Health Distinguished Research Professor of Philosophy and Oswaldo Cruz Foundation, Brazil Psychology; Director, Milton & Ethel Harris Research Barry Kistnasamy MBChB Mmed Initiative, York University, Canada Head, Occupational Health, Department of Health Pastor Castell-Florit MD PhD DSc South Africa Director, National School of Public Health, Cuba Augusto Sola MD Patrick Kuma-Aboagye MB-BCH MPH Neonatologist, St Jude’s Hospital and Children’s José F. Cordero MD MPH Deputy Director and Head Hospital, Orange County, California, USA Patel Distinguished Professor of Public Health Reproductive and Child Health Department Chair, Department of Epidemiology and Biostatistics Ghana Health Service, Ghana Ronald St. John MD MPH College of Public Health, University of Georgia, USA President, St. John Public Health Consulting Albert Kuperman PhD International, Canada Yamila de Armas MD Emeritus Associate Dean for Medical Education Professor, National School of Public Health, Cuba Albert Einstein College of Medicine of Yeshiva Pedro Urra MS University, USA Full Professor, University of Havana, Cuba Maria Cecilia de Souza Minayo MS PhD Professor of Sociology Margaret Larkins-Pettigrew MD MEd MPPM Pedro A. Valdés-Sosa MD PhD National School of Public Health, Brazil Assistant Professor, Global Health/OB-GYN and Reproductive Biology, Univ Hospitals, Case Medical Deputy Director, Neuroscience Center, Cuba Timothy De Ver Dye MS MA MPA PhD Center & MacDonald Women’s Hospital, USA Professor, OB–GYN and Pediatrics Luis F. Vélez MD MPH PhD Public Health Sciences and Medical Informatics Linh Cu Le MD MSc PhD Director, Program Development, Evaluation University of Rochester School of Medicine and Associate Professor of Public Health and Quality Improvement Dentistry, USA Vinmec International Hospital JSC, Viet Nam DePelchin Children’s Center, USA Roger Downer PhD DSc FRSC MRIA Noni MacDonald MD MSc FRCPC FCAHS Howard Waitzkin MD PhD FACP President Emeritus, University of Limerick, Ireland Professor of Pediatrics and Computer Science Distinguished Professor Emeritus Dalhousie University, Canada University of New Mexico, USA Leith L. Dunn PhD Senior Lecturer & Head, Institute for Gender Pedro Más MD PhD DSc Suwit Wibulpolprasert