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United States Patent (19) 11 Patent Number: 5,695,752 Rosen Et Al US00569.5752AIII United States Patent (19) 11 Patent Number: 5,695,752 Rosen et al. 45 Date of Patent: Dec. 9, 1997 (54) TREATING INFLAMMATION WIA THE Stoolman et al., “Phosphomannosyl Receptors May Partici ADMINISTRATION OF SPECIFIC pate in the Adhesion Interaction between Lymphocytes and SULFATASE ENZYMES AND/OR SULFATION High Endothelial Venules". J. Cell Biol, 99:1535-1540 INHIBITOR (1984). Willenborg et al., "Phosphosugars are potent inhibitors of 75) Inventors: Steven D. Rosen; Stefan Hemmerich, central nervous system inflammation'. Faseb. J., both of San Francisco, Calif.; Yasuyuki 3:1968-1971 (1989). Imai, Tokyo, Japan Willenborg et al., "Inhibition of Allergic Encephalomyeltis in Rats by Treatment With Sulfated Polysaccharides". J. 73) Assignee: The Regents of the University of Immunol., 140:3401-3405 (1988). California, Oakland, Calif. 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