JOURNAL of VIROLOGY Volumel6 Contents for December Number6 Animal Viruses Uukuniemi Virus Contains an RNA Polymerase

Total Page:16

File Type:pdf, Size:1020Kb

JOURNAL of VIROLOGY Volumel6 Contents for December Number6 Animal Viruses Uukuniemi Virus Contains an RNA Polymerase JOURNAL OF VIROLOGY Volumel6 Contents for December Number6 Animal Viruses Uukuniemi Virus Contains an RNA Polymerase. MARJUT RANKI AND RALF F. PETTERSSON* .1420 Isolation of RNA Transcripts from the Entire Sendai Viral Genome. LAURENT RoUX AND DANIEL KOLAKOFSKY* .1426 Characterization of the mRNA of Influenza Virus. SYLVIA E. GLASS, DUNCAN MCGEOCH,* AND RICHARD D. BARRY .1435 Complementation Between Temperature-Sensitive and Deletion Mutants of Reovirus. D. A. SPANDIDOS AND A. F. GRAHAM* .1444 Role of Carbohydrate in Determining the Immunochemical Properties of the Major Glycoprotein (gp7l) of Friend Murine Leukemia Virus. D. P. BOLOGNESI,* J. J. COLLINS, J. P. LEIS, V. MOENNIG, W. SCHXFER, AND P. H. ATKINSON .... 1453 Purification of Influenza Viral Complementary RNA: Its Genetic Content and Activity in Wheat Germ Cell-Free Extracts. POLLY R. ETKIND AND ROBERT M. KRUG* .1464 Thermolabile Reverse Transcriptase of a Mammalian Leukemia Virus Mutant Temperature Sensitive in Its Replication and Sarcoma Virus Helper Func- tions. STEVEN R. TRONICK, JOHN R. STEPHENSON, INDER M. VERMA, AND STUART A. AARONSON* .1476 Homology Between Avian Oncornavirus RNAs and DNA from Several Avian Species. M. SHOYAB AND M. A. BALUDA* .1492 Regulation of Macromolecular Synthesis in Reovirus-Infected L-929 Cells. I. Effect of L-Histidinol. R. C. WARRINGTON* AND N. WRATTEN .... .......... 1503 Replication of Picornaviruses. I. Evidence from In Vitro RNA Synthesis that Poly(A) of the Poliovirus Genome is Genetically Coded. KAROLINE DORSCH- HXSLER, YOSHIAKI YOGO, AND ECKARD WIMMER* .1512 Physical Properties of Moloney Murine Leukemia Virus High-Molecular-Weight RNA: a Two Subunit Structure. CHARLES H. RIGGIN, MAURICE BONDURANT, AND WILLIAM M. MITCHELL* .1528 Human Cytomegalovirus. IV. Specific Inhibition of Virus-Induced DNA Polymerase Activity and Viral DNA Replication by Phosphonoacetic Acid. ENG-SHANG HUANG .1560 Transcription of 70S RNA by DNA Polymerases from Mammalian RNA Viruses. JOHN W. ABRELL, MARVIN S. REITZ, AND ROBERT C. GALLO* .1566 Effect of Cordycepin (3'-Deoxyadenosine) on Virus-Specific RNA Species Synthe- sized in Newcastle Disease Virus-Infected Cells. SUSAN REICH WEISS AND MICHAEL A. BRATT* .1575 Synthesis of Herpes Simplex Virus, Vaccinia Virus, and Adenovirus DNA in Iso- lated HeLa Cell Nuclei. I. Effect of Viral-Specific Antisera and Phosphono- acetic Acid. ARTHUR BOLDEN, JAYME AUCKER, AND ARTHUR WEISSBACH* .... .. 1584 Effect of the Fv-1 Locus on the Titration of Murine Leukemia Viruses. PAUL JOLICOEUR AND DAVID BALTIMORE* .1593 Relationships Among the Polypeptides of Newcastle Disease Virus. LAWRENCE E. HIGHTOWER, TRUDY G. MORRISON, AND MICHAEL A. BRATT* .1599 tRNA's Associated with the 70S RNA of Avian Myeloblastosis Virus. LARRY C. WATER,* BETH C. MULLIN, EDDIE G. BAILIFF, AND RAYMOND A. Popp ... 1608 Tryptic Peptide Analysis of Nonstructural and Structural Precursor Proteins from Continued on following page Continued from preceding page Semliki Forest Virus Mutant-Infected Cells. BAT-EL LACHMI, NIALL GLAN- VILLE, SIRKKA KERANEN, AND LEEVI KXXRIXINEN* .1615 Nuclear Polyhedrosis Virus Detection: Relative Capabilities of Clones Developed from Trichoplusia ni Ovarian Cell Line TN-368 to Serve as Indicator Cells in a Plaque Assay. LoY E. VOLKMAN* AND MAX D. SUMMERS .1630 Replication and Persistence of Measles Virus in Defined Subpopulations of Human Leukocytes. BARRY S. JOSEPH, PETER W. LAMPERT, AND MICHAEL B. A. OLD- STONE*.1638 Block to Multiplication of Adenovirus Serotype 2 in Monkey Cells. DANIEL F. KLESSIG* AND CARL W. ANDERSON .1650 Adenovirus Assembly: Self-Assembly of Partially Digested Hexons. PIERRE A. BOULANGER .1678 Bacterial Viruses Thymineless Bacteriophage Induction in Staphylococcus aureus. I. High-Frequency Transduction with Lysates Containing a Bacteriophage Related to Bacterio- phage 511. LARS RUDIN AND MARTIN LINDBERG*.1357 Thymineless Bacteriophage Induction in Staphylococcus aureus. II. Specific Trans- duction of Constitutive and Inducible Erythromycin Resistance. MARTIN LINDBERG* AND LARS RUDIN.1367 Alkali Lability of Bacteriophage XW-14 DNA. HILARY ANN LEWIS, R. C. MILLER, JR., J. C. STONE, AND R. A. J. WARREN* .1375 F-Factor-Mediated Restriction of Bacteriophage T7: Synthesis of RNA and Protein in T7-Infected Escherichia coli F- and F+ Cells. PATRICIA A. WHITAKER, YOSHIHIKO YAMADA, AND DAI NAKADA* .1380 Bacteriophage T4 Baseplate Components. I. Binding and Location of the Folic Acid. LLOYD M. KOZLOFF,* MURL LUTE, AND LOUISE K. CROSBY .1391 Bacteriophage T4 Baseplate Components. II. Binding and Location of Bacterio- phage-Induced Dihydrofolate Reductase. LLOYD M. KOZLOFF,* LOUISE K. CROSBY, MURL LUTE, AND DWIGHT H. HALL .1401 Bacteriophage T4 Baseplate Components. III. Location and Properties of the Bacteriophage Structural Thymidylate Synthetase. LLOYD M. KOZLOFF,* LOUISE K. CROSBY, AND MURL LUTE .1409 F-Factor-Mediated Restriction of Bacteriophage T7: Protein Synthesis in Cell- Free Systems from T7-Infected Escherichia coli F- and F+ Cells. YOSHIHIKO YAMADA AND DAI NAKADA* .1483 Bacteriophage P22 Virion Protein Which Performs an Essential Early Function. I. Analysis of 16 ts Mutants. BARBARA HOFFMAN AND MYRON LEVINE* .. .. .. .. 1536 Bacteriophage P22 Virion Protein Which Performs an Essential Early Function. II. Characterization of the Gene 16 Function. BARBARA HOFFMAN AND MYRON LEVINE* .1547 Identification of P48 and P54 as Components of Bacteriophage T4 Baseplates. PETER B. BERGET AND HUBER R. WARNER* .1669 Chemical Stability of Bacteriophage T7 Early mRNA. YOSHIHIKO YAMADA, PA- TRICIA A. WHITAKER, AND DAI NAKADA* .1683 Errata Interferon-Directed Inhibition of Chronic Murine Leukemia Virus Production in Cell Cultures: Lack of Effect on Intracellular Viral Markers. ROBERT M. FRIEDMAN,* ESTER H. CHANG, JANET M. RAMSEUR, AND MAUREEN W. MYERS .... 1688 Purification and Properties of Spleen Necrosis Virus DNA Polymerase. SATOSHI Continued on following page Continued from preceding page MIZUTANI AND HOWARD M. TEMIN* .. ....... .. .. .... .... .. .. .... .. .. .. .. 1688 Structure, Subunit Composition, and Molecular Weight of RD-114 RNA. HSING- JIEN KUNG, JAMES M. BAILEY, NORMAN DAVIDSON,* MARGERY 0. NICOLSON, AND ROBERT M. MCALLISTER .......... .. .. .... ................. ... 1688 * Asterisk refers to person to whom inquiries regarding the paper should be addressed..
Recommended publications
  • Replication of Picornaviruses I
    JouRNAL oF VnoLoGy, Dec. 1975, p. 1512-1527 Vol. 16, No. 6 Copyright ©) 1975 American Society for Microbiology Printed in U.SA. Replication of Picornaviruses I. Evidence from In Vitro RNA Synthesis that Poly(A) of the Poliovirus Genome is Genetically Coded KAROLINE DORSCH-HASLER, YOSHIAKI YOGO,' AND ECKARD WIMMER* Department ofMicrobiology, St. Louis University School ofMedicine, St. Louis, Missouri 63104, and Department ofMicrobiology, School ofBasic Health Sciences, State University ofNew York at Stony Brook, Stony Brook, New York 11794 * Received for publication 3 July 1975 A crude replication complex has been isolated from poliovirus-infected HeLa cells and used for synthesis of poliovirus replicative intermediate (RI) RNA, replicative form (RF) RNA, and single-stranded (SS) RNA in vitro. All three classes of virus-specific RNA synthesized in vitro are shown to contain poly(A). Poly(A) of RF and of SS RNA [RF-poly(A) and SS-poly(A)] has a chain length (50 to 70 nucleotides) that is shorter than that of poly(A) of in vivo-synthesized RNAs. Poly(A) of RI [RI-poly(A)], however, is at least 200 nucleotides long and, therefore, larger than poly(A) of RI isolated from HeLa cells 4 h after infection. The crude membrane-bound replication complex contains a terminal adenylate transferase activity that is stimulated by Mn2+ and the addition of an (Ap),AoH primer. This transferase activity is found also in extracts of mock-infected cells. Partial purification of the replication complex in a stepwise sucrose gradient, in which the viral replicase is associated with the smooth cytoplasmic membrane fraction, does not remove the terminal transferase.
    [Show full text]
  • Abstract Book (Pdf)
    6th EMBO/EMBL Conference on Science and Society Science and Security 28 – 29 October 2005 at the European Molecular Biology Laboratory Heidelberg, Germany Organising Committee: Andrew Moore (EMBO, Chair), Halldòr Stefànsson (EMBL), Alessandra Bendiscioli (EMBO), Frank Gannon (EMBO), Iain Mattaj (EMBL) Welcome message n September this year, plans for a new bio-defence laboratory in Montana, USA, were Iunveiled. In the $66.5 million facility, researchers will apply similar scientific knowledge to that which makes bio-terrorism or biological warfare a possibility in the first place. The double-edged sword of science application can hardly be more evident. How successfully can we prevent the misuse of research findings that otherwise give us important insights into the workings of nature and prospects of useful applications? What would be the consequences of tackling this problem by constraining research, the mobility of researchers and the funding and publication of their research? Could we, indeed, ever successfully define “research that should not be done”? How much thought should scientists give to the downstream consequences of their work when deciding what to research, or which experiments to do? In June this year, the USA announced that it would delay the introduction of compulsory biometric passports for travellers from 27 countries in Europe and the Asia-Pacific region until October 2006. But whenever they appear, biometric passports will be part of normal life in the future. In the era of international terrorism, this could, indeed, lead to a safer world; an example of a beneficial use of science. On the other hand, it increases the perception by normal citizens that they are being unnecessarily “watched” by an all- seeing, all-controlling state – the so-called Big Brother of Orwell’s 1984.
    [Show full text]
  • “Let There Be Life”
    Focus: Brave New World “We have reason to believe that the disease is created by a man-made super pathogen...” AND MAN SAID, “LETa short story THERE BE LIFE” By Lawrence Valverde e have reason to believe the nearly 200 scientists simmered with “Wdisease is caused by a man- mumbled comments. The researcher made super-pathogen. The construc- whose speech had been interrupted tion seems to be loosely based on the straightened himself and raised his smallpox virus, but with significant voice in response. modifications, including genes encod- “I hear your concern, Dr. Boots, ing immune system antagonists. It but we have not confirmed whether or also seems to have been specifically not this is, in fact, a terrorist act…” engineered to resist known antivi- “Who else would do such a thing, ral…” Dr. Cervantes?” Dr. Boots demanded. “What do you mean specifically “It wasn’t necessarily done on engineered!” boomed an overweight purpose…” said Dr. Cervantes—the man as he hauled himself out of speaker—but he was interrupted by his chair. “Are you proposing that the clamor that erupted as scientists terrorists may have the technology jump up from their seats. Dr. Cervantes to synthetically create their own vi- frowned. Trying to speak over the ruses?” The surrounding panel of crowd was clearly a lost cause. When credit: Clipart courtesy FCIT. http://etc.usf.edu/clipart credit: Clipart courtesy FCIT. fall 2008 • Harvard Science Review 9 valverde.indd 9 2/9/2009 11:24:54 PM Focus: Brave New World did this whole business with artificially Dr. Boots sputtered.
    [Show full text]
  • Profile of Eckard Wimmer
    PROFILE Profile of Eckard Wimmer he finding caused an uproar. vitalism—the belief that chemicals in liv- Researchers at Stony Brook Uni- ing systems are somehow distinct from Tversity in New York had engi- the chemicals in inorganic systems, such neered poliovirus in a test tube as salt and rocks. That notion was shat- (1). The discovery, led by Eckard Wimmer, tered in 1828, when German chemist elected in 2012 to the National Academy Friedrich Wöhler synthesized the organic of Sciences, dispelled the belief that compound urea from inorganic pre- viruses require a live host to grow cursors (5). and spread. By the 1940s, theoretical physicists and The thought of synthetic viruses terrified biochemists had begun to wonder about an American public still reeling from 9/11 what constitutes life. Wimmer was en- and the subsequent anthrax attacks. What thralled. Biochemistry squared perfectly if the technology to engineer viruses with his worldview, the idea that something wound up in the hands of bioterrorists? as seemingly profound as life could be pared However, today, just a decade later, it is down to its simplest—chemical—form. widely accepted that the ability to engineer While completing his second post- viruses also allows researchers to develop doctoral fellowship at the University of viruses that work as synthetic vaccines, British Columbia in Vancouver in the to carry genetic material into a cell for use mid-1960s, Wimmer attended a talk on in gene therapies, or to preferentially viruses and had his eureka moment. “It attack cancer cells (2). was clear, even though it wasn’t men- Wimmer says his motivations for engi- tioned in that talk, that if viruses can be neering polio were strictly scientific.
    [Show full text]
  • Bert Lawrence Semler
    Curriculum Vitae: Bert Lawrence Semler Contact Information Department of Microbiology and Molecular Genetics School of Medicine, Med Sci B237 University of California Irvine, CA 92697 USA E-mail: [email protected] Phone: (949) 824-7573 FAX: (949) 824-2694 Education 1970-1974 University of California, Irvine Bachelor of Science - Biological Sciences 1974-1979 University of California, San Diego Doctor of Philosophy - Biology Research and Professional Experience 1972-1974 Undergraduate research with Professor H. W. Moore Department of Chemistry, University of California, Irvine 1975-1979 Graduate student with Professor John J. Holland Department of Biology, University of California, San Diego 1979-1983 Postdoctoral fellow with Professor Eckard Wimmer, Department of Microbiology, State University of New York at Stony Brook 1983-1987 Assistant Professor, Department of Microbiology and Molecular Genetics College of Medicine, University of California, Irvine 1987-1991 Associate Professor, Department of Microbiology and Molecular Genetics College of Medicine, University of California, Irvine 1991-2018 Professor, Department of Microbiology and Molecular Genetics School of Medicine, University of California, Irvine 1996-2006 Chair, Department of Microbiology and Molecular Genetics School of Medicine, University of California, Irvine 2000-2010 Associate Director, Center for Virus Research University of California, Irvine 2010-present Director, Center for Virus Research University of California, Irvine 2018-present Distinguished Professor, Department
    [Show full text]
  • NAT265 NEW Mx
    news Poliovirus advance sparks fears of data curbs Erika Check, Washington The recent laboratory synthesis of an infec- tious poliovirus is prompting fears among SCIENCE US biologists that the publication of results GETTY IMAGES deemed potentially useful to terrorists may be restricted. The virus was synthesized by a team led by virologist Eckard Wimmer at the State University of New York at Stony Brook. The results, published online by Science on 11 July (J. Cello, A. V. Paul & E. Wimmer Science 10.1126/science.1072266), sparked media reports worldwide suggesting that similar techniques might be used by terrorists to synthesize the Ebola virus or even smallpox. For Eckard Wimmer, his results brought a ‘scary Culture shock: researchers have synthesized this Geneticists fear that the report — the first realization’ that viruses can be recreated. infectious poliovirus in the laboratory. demonstration that a published genome can be turned into an infectious virus — will been used to demonstrate the technique. sequence information. He claims that the encourage calls for a clampdown on the open Wimmer defends his group’s decision to latest research proves that the world can publication of gene sequences of viruses. publish, saying that they are only pointing never stop vaccinating against polio. “You US government officials have been floating out the fact that terrorists could misuse cannot eliminate a virus from existence,” he the idea of such restrictions since the terror- published data. “We’ve been criticized for says. “Somebody can always resynthesize it, ist attacks last autumn (see Nature 414, playing into the hands of a bioterrorist, but and that’s a scary realization.” 237–238; 2001).
    [Show full text]
  • Defective Interfering Particles of Poliovirus I
    JOURNAL OF VIROLOGY, Apr. 1971, p. 478-485 Vol. 7, No. 4 Copyright © 1971 American Society for Microbiology Printed int U.S.A. Defective Interfering Particles of Poliovirus I. Isolation and Physical Properties CHARLES N. COLE, DONNA SMOLER, ECKARD WIMMER, AND DAVID BALTIMORE Departmenit of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Received for publication 8 January 1971 A class of defective interfering (DI) poliovirus particles has been identified. The first was found as a contaminant of a viral stock; others have been isolated by serial passage at a high multiplicity of infection. The DI particles are less dense than standard virus and sediment more slowly. Their ribonucleic acid (RNA) sediments more slowly than standard RNA and has a higher electrophoretic mobility. Compe- tition hybridization experiments with double-stranded viral RNA indicate that DI RNA is 80 to 90'- of the length of standard RNA. The proteins of DI particles are indistinguishable from those of standard poliovirus. Defective interfering (DI) particles are found (ii) virus diluted serially in medium; (iii) HeLa cells in stocks of many different types of viruses (9). washed twice with medium and resuspended at 107/ml These particles are a natural form of mutant in medium plus 1 horse serum. A mixture of 0.2 which could be useful in the study of viral multi- ml of a given virus dilution with 0.6 ml of cells and 0.6 ml of agar were spread rapidly over base layer plication. They are also of interest because of plates at room temperature, and plates were incu- their possible role in viral disease processes (9).
    [Show full text]
  • Synthetic Biology: Synthesis and Modification of a Chemical Called Poliovirus
    Synthetic biology: Synthesis and modification of a chemical called poliovirus Steffen Mueller, Dimitris Papamichail, John Robert Coleman, Jeronimo Cello, Aniko Paul, Steven Skiena, and Eckard Wimmer SUNY–Stony Brook, U.S.A. Synthetic biology is a newly emerging scientific field, encompassing knowledge of different disciplines, such as engineering, physics, chemistry, computer sciences, mathematics, and biology. Synthetic biology aims to create novel biological systems with functions that do not exist in nature. There seem infinite possibilities of constructing unique derivatives of existing organisms (bacteria, yeast, viruses). Apart from designing novel building elements for engineering biological systems, a fundamental requirement in synthetic biology is the ability of large-scale DNA synthesis and DNA sequencing. Viruses can be described in chemical terms; the empirical formula of the organic matter of poliovirus being:1 C332,652H492,388N98,245O131,196P7,501S2,340. Placing these atoms into order, a particle of high symmetry emerges2 with all the properties required for its proliferation and “survival” in nature. These properties are encoded in the viral genome, which is a single stranded nucleic acid (RNA) of about 7,500 nucleotides. Guided by the published nucleotide sequence,3 we have recently synthesized the DNA equivalent of the polio RNA genome and converted it by simple biochemical manipulations in a cell-free environment (outside living cells) into authentic poliovirus particles.4 The synthesis of a replicating "organism" in the absence of a natural template was without precedence at the time of publication4 and it provoked widespread responses – good and bad. Poliovirus is a human virus that replicates after ingestion in the gastrointestinal tract.
    [Show full text]
  • Profile of Eckard Wimmer
    PROFILE Profile of Eckard Wimmer he finding caused an uproar. vitalism—the belief that chemicals in liv- Researchers at Stony Brook Uni- ing systems are somehow distinct from Tversity in New York had engi- the chemicals in inorganic systems, such neered poliovirus in a test tube as salt and rocks. That notion was shat- (1). The discovery, led by Eckard Wimmer, tered in 1828, when German chemist elected in 2012 to the National Academy Friedrich Wöhler synthesized the organic of Sciences, dispelled the belief that compound urea from inorganic pre- viruses require a live host to grow cursors (5). and spread. By the 1940s, theoretical physicists and The thought of synthetic viruses terrified biochemists had begun to wonder about an American public still reeling from 9/11 what constitutes life. Wimmer was en- and the subsequent anthrax attacks. What thralled. Biochemistry squared perfectly if the technology to engineer viruses with his worldview, the idea that something wound up in the hands of bioterrorists? as seemingly profound as life could be pared However, today, just a decade later, it is down to its simplest—chemical—form. widely accepted that the ability to engineer While completing his second post- viruses also allows researchers to develop doctoral fellowship at the University of viruses that work as synthetic vaccines, British Columbia in Vancouver in the to carry genetic material into a cell for use mid-1960s, Wimmer attended a talk on in gene therapies, or to preferentially viruses and had his eureka moment. “It attack cancer cells (2). was clear, even though it wasn’t men- Wimmer says his motivations for engi- tioned in that talk, that if viruses can be neering polio were strictly scientific.
    [Show full text]
  • Doctor Atomic and Doctor Genomic
    GENDER MEDICINE/VOL. 5, NO. 4, 2008 Editorial Doctor Atomic and Doctor Genomic As I watched Doctor Atomic, John Adams’ fascinating new production with The Metropolitan Opera that dramatizes the Manhattan Project’s creation of the atomic bomb, I applauded the brilliant portrayal of the dilemma that our greatest scientific achievements pose. Because of their completely novel and tremen- dous power, these achievements have the potential for both enormous good and unimaginably terrible consequences. The opera’s libretto used original sources, and in their own words described the gut-wrenching tensions among the scientists involved in making the bomb. No imagined dialogue could possibly have been more compelling. Edward Teller and Robert Wilson tried, unsuccessfully, to persuade their colleagues to petition President Truman to refrain from dropping the bomb on Japan. Yet Robert Oppenheimer, the complex, highly cultured, and charismatic project leader whom Adams dubbed “Dr. Atomic,” pushed the testing of the device to completion, despite his own misgivings. He later said, “As I watched the explosion, I thought of a quotation from the Bhagavad Gita: ‘I am become death, the destroyer of worlds.’” The average age of the more than 300 men and women who worked on the Manhattan Project was 25. At Los Alamos, beer drinking, lovemaking, and frenzied devotion to finishing the project were all, predict- ably, going on at once. Many worked to the point of exhaustion: one young scientist was hospitalized with a nervous breakdown. The opera touched on the thousand difficulties faced by Oppenheimer as he knit the project together despite the disparate enthusiasms, misgivings, and diametrically opposed moti- vations of the gifted scholars, many of them Nobel laureates, who worked to complete it.
    [Show full text]
  • Discover the World of Microbes Related Titles
    Gerhard Gottschalk Discover the World of Microbes Related Titles Dale, J. W., Park, S. F. Molecular Genetics of Bacteria 2010 ISBN: 978-0-470-74184-9 Krämer, R., Jung, K. (eds.) Bacterial Signaling 2010 ISBN: 978-3-527-32365-4 Feldmann, H. Yeast Molecular and Cell Biology 2010 ISBN: 978-3-527-32609-9 Wiegel, J., Maier, R., Adams, M. (eds.) Incredible Anaerobes From Physiology to Genomics to Fuels ISBN: 978-1-57331-705-4 Wilson, M. Bacteriology of Humans An Ecological Perspective 2008 ISBN: 978-1-4051-6165-7 Gerhard Gottschalk Discover the World of Microbes Bacteria, Archaea, and Viruses The Author Limit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in Prof. Dr. Gerhard Gottschalk preparing this book, they make no representations Institut für Mikrobiologie und or warranties with respect to the accuracy or Genetik completeness of the contents of this book and Georg-August-Universität specifically disclaim any implied warranties of Grisebachstr. 8 merchantability or fitness for a particular purpose. 37077 Göttingen No warranty can be created or extended by sales Germany representatives or written sales materials. The advice and strategies contained herein may not be Cover suitable for your situation. You should consult with The cover was designed by Anne a professional where appropriate. Neither the Kemmling, Göttingen. Source of publisher nor authors shall be liable for any loss of the micrographs (left to right: profit or any other commercial damages, including row 1, Anne Kemmling; row 2, but not limited to special, incidental, consequential, Manfred Rohde, Braunschweig, or other damages.
    [Show full text]
  • Celebratory Speech by Professor Dr
    Laudatio by Prof. Dr. Hans-Georg Kräusslich for Prof. Dr. Eckard Wimmer [Check against delivery.] [Address] “A Heart for Viruses” - that was the title of an article on Eckard Wimmer in the ‘My Career – Jobs and Opportunities’ column in the German newspaper Frankfurter Allgemeine Zeitung this July. It is surely no coincidence that Ernst-Ludwig Winnacker, the 2011 Robert Koch Gold Medal winner wanted to call one of his books “I Love Viruses”. Given that these pathogens cause many diseases, this title was deemed to have too much potential for misunderstanding, and changed to “Viruses, the Secret Rulers” in the end. This fascination with the astonishing properties of these miniscule pathogens and their importance for the evolution and development of illnesses is what unites Eckard Wimmer and Ernst-Ludwig Winnacker, and forms a link to last year’s award. By awarding him the Robert Koch Gold Medal, we are now honouring Eckard Wimmer's life's work and his great contribution to polio virus research, and to the development of molecular virology as a whole. Eckard Wimmer is a chemist, as evidenced by the way he approaches his research subjects and what drives him in his work. Of course, this is mainly the desire to understand an important pathogen and its ability to reproduce and spread, as well as to explain its pathogenic potential. He concentrated on the virus which causes infantile paralysis, the polio virus, an ancient pathogenic virus that wreaked havoc on mankind for many centuries. Today, the polio virus is one of the most thoroughly studied viruses, in no small part thanks to Eckard Wimmer’s research.
    [Show full text]