JOURNAL OF

VOLUME 49 * MARCH 1984 0 NUMBER 3 Edward M. Scolnick, Editor in Chief (1987) Merck Sharp & Dohme Research Laboratories West Point, Pa. David T. Denhardt, Editor (1987) Harold S. Ginsberg, Editor (1984) Michael B. A. Oldstone, Editor (1988) University of Western Ontario Columbia University Scripps Clinic & Research Foundation London, Ontario, Canada New York, N.Y. La Jolla, Calif. Bernard N. Fields, Editor (1988) Robert M. Krug, Editor (1987) Robert A. Weisberg, Editor (1988) Harvard Medical School Sloan-Kettering Institute National Institute of Child Health and Boston, Mass. New York, N.Y. Human Development Bethesda, Md. EDITORIAL BOARD (1984) Hidesaburo Hanafusa (1986) Bernard Moss (1986) Bart Sefton (1985) Amiya K. Banerjee (1985) William S. Hayward (1984) Fred Murphy (1986) Phillip A. Sharp (1985) Andrew Becker (1985) Martin Hirsch (1986) Nancy G. Nossal (1984) Thomas E. Shenk (1984) Tamar Ben-Porat (1984) John J. Holland (1984) Abner Notkins (1986) Charles J. Sherr (1984) Kenneth I. Berns (1985) Ian H. Holmes (1986) J. Thomas Parsons (1986) Saul J. Silverstein (1985) Michael Botchan (1986) Robert W. Honess (1986) Ulf G. Petterson (1986) Lee D. Simon (1984) David Botstein (1985) Nancy Hopkins (1986) Lennart Philipson (1984) Ann Skalka (1985) Dennis T. Brown (1984) Peter M. Howley (1984) Lewis I. Pizer (1984) Ahmad I. Bukhari (1984) Alice S. Huang (1984) Craig R. Pringle (1986) Patricia G. Spear (1984) Barrie J. Carter (1984) Tony Hunter (1986) Carol Prives (1986) Nat Sternberg (1986) Purnell Choppin (1986) Masayori Inouye (1985) Robert Purcell (1986) Mark F. Stinski (1986) John M. Coffin (1986) Robert Kamen (1985) Fred Rapp (1984) F. William Studier (1984) Geoffrey M. Cooper (1984) Thomas J. Kelly, Jr. (1985) Dan S. Ray (1986) Lawrence S. Sturman (1985) Richard Courtney (1986) George Khoury (1984) M. E. Reichmann (1985) Jesse Summers (1985) Walter Doerfler (1986) Elliott Kieff (1984) Gordon M. Ringold (1984) William Summers (1985) Peter Dougherty (1986) Jonathan A. King (1984) Harriet Robinson (1985) John M. Taylor (1984) Harrison Echols (1984) Daniel Kolakofsky (1986) William S. Robinson (1986) Howard M. Temin (1985) Elvera Ehrenfeld (1986) Robert Lamb (1985) Bernard Roizman (1985) George F. Vande Woude (1986) Robert N. Eisenman (1985) Robert A. Lazzarini (1984) Naomi Rosenberg (1986) Inder Verma (1986) Suzanne U. Emerson (1986) Myron Levine (1985) Roland R. Rueckert (1985) Edward K. Wagner (1986) S. Jane Flint (1984) Douglas R. Lowy (1986) Norman P. Salzman (1984) Eckard Wimmer (1985) Yasuhiro Furuichi (1985) Robert Martin (1984) Joseph Sambrook (1985) Owen Witte (1986) Costa Georgopolous (1986) Thomas Merigan (1986) Charles Samuel (1986) Charles Hamish Young (1986) Walter Gerhard (1986) George Miller (1984) Priscilla A. Schaffer (1984) Julius S. Youngner (1986) Larry M. Gold (1985) Lois K. Miller (1985) Sondra Schlesinger (1986) Peter Gruss (1985) Peter Model (1986) June R. Scott (1986)

Helen R. Whiteley, Chairman, Publications Board Walter G. Peter III, Director of Publications Linda M. Illig, Managing Editor, Journals Paula R. Ellison, Production Editor

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination offundamental knowledge concerning of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry, biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Department. The Journal is issued monthly, four volumes per year. The nonmember subscription price is $249 per year; single copies are $21. The member subscription price is $37 (foreign, $49 [surface rate]) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs, disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Department, 1913 I St., NW, Washington, DC 20006 (phone: 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because offailure to report an address change or for issues "missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Journal of Virology, ASM, 1913 I St., NW, Washington, DC 20006. Made in the U.S.A. Copyright © 1984, American Society for Microbiology. E*: {rllif+kuJ ( I Jkt. All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the arti- cle may be made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated per-copy fee through the Copyright Clearance Center, 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Anderson, Carl W., 692, 873 Fleckenstein, Bernhard, 938 Kohler, Martin, 658 Rafield, Lori F., 960 Anderson, Steven M., 881 Friedrich, Roland, 828 Kolakofsky, Daniel, 680 Ramig, Robert F., 665 Arsenakis, Minas, 813 Friedrichs, William E., 992 Kozak, Christine, 1005 Reagan, Kevin J., 635 Kuhn, Andreas, 902 Rice, Patricia L., 766 Robertson, Alice T., 652 Babiss, Lee E., 731 Galibert, Francis, 782 Roizman, Bernard, 813 Baltimore, David, 686 Gallahan, Daniel, 1005 Langer, Charlotte A., 701 Rombaut, B., 1002 Barisas, B. George, 980 Galloway, Denise A., 724 Leuther, Michael D., 980 Rose, John W., 988 Basilico, Claudio, 984 Gentsch, Jon R., 641 Levine, Arnold J., 692 Rosenthal, Ken S., 980 Bates, Robert C., 652 Gerin, John L., 701 Levine, Myron, 947 Rueckert, Roland R., 873 Beckson, Mace, 881 Gilboa, Eli, 686 Lomniczi, Bela, 970 Rundell, M. Kathleen, 997 Beigel, Michel, 1009 Ginsberg, H. S., 731 London, William, 848 Bellini, William J., 988 Girard, M., 717 Loyter, Abraham, 1009 Salzman, Lois A., 1018 Ben-Porat, Tamar, 970 Glorioso, Joseph C., 947 Sandri-Goldin, Rozanne M., 94' Blankenship, Mayme Lee, 970 Goff, Stephen P., 909, 918 Boettiger, David, 841 Sarnow, Peter, 692 Goldberg, Barbara, 635 Mackett, Michael, 857 Schirm, Sabine, 938 Boeye, A., 1002 Goldin, Alan L., 947 Bouck, Noel, 997 Maeder, Marlies, 892, 902 Schlesinger, Sondra, 865 Gordon, Marc L., 918 Mandart, Elisabeth, 782 Schwartzberg, Pamela, 918 Bouloy, M., 717 Graham, Dale E., 819 Brown, Dale D., 1018 Mauel, Catherine, 806 Semler, Bert L., 873 Grose, Charles, 992 McFarland, Henry F., 988 Shenk, Thomas, 692 Grubman, Marvin J., 760 McFarlin, Dale E., 988 Shenoy, Suresh, 674 McKeever, Paul E., 848 Smith, Geoffrey L., 857 Callahan, Robert, 1005 Medina, Daniel, 819 Smith, Gilbert H., 819 Carter, V. Celeste, 766 Halbert, Donald N., 692 Meyer, Thomas, 709 Spear, Patricia G., 741 Champoux, James J., 686 Hanafusa, Hidesaburo, 881 Miller, Nancy R., 848 Stout, Ernest R., 652 Chejanovsky, Nor, 1009 Hassell, John A., 925 Monroe, Stephan S., 865 Swain, Margaret A., 724 Cloyd, Miles W., 772 Hearing, Patrick, 692 Montenarh, Mathias, 658 Colicelli, John, 918 Henning, Roland, 658 Moss, Bernard, 857 Cote, Paul J., 701 Hirai, Kanji, 1014 Muller, Ingrid, 938 Templeton, Dennis, 799 Crawford, Sarah, 909 Holland, John J., 793 Tevethia, Satvir S., 766 Crowell, Richard L., 635 Holland, Louis E., 947 Traub, Franz, 892, 902 Horisberger, Michel A., 709 Nichol, Stuart T., 793 Horodyski, Frank M., 793 Dailey, Lisa, 984 Ueda, Shigeharu, 1014 Desrosiers, Ronald C., 938 O'Hara, Patrick J., 793 Drexler, Henry, 754 Ikuta, Kazuyoshi, 1014 Oliff, Allen, 828 Vialat, P., 717 Durban, Elisa, 841 Omilianowski, Daniel R., 873 Vrijsen, R., 1002

Jennings, Stephen R., 766 Walker, Duard L., 848 Eckhart, Walter, 799 Padgett, Billie L., 848 Ehrlich, Melanie, 674 Wallen, William C., 848 Pallansch, Mark A., 873 Wang, Lu-Hai, 881 Engle, Ronald E., 701 Karamata, Dimitri, 806 Pardigon, N., 717 Evans, Leonard H., 772 Wang, Richard Y.-H., 674 Kato, Shiro, 1014 Patterson, Jean L., 680 Williams, Bryan R. G., 748 Kay, Alan, 782 Pellegrini, Sandra, 984 Wimmer, Eckard, 873 Keller, Beat, 902 Penn, Linda J. Z., 748 Fields, Bernard N., 641 Kew, Olen M., 873 Petrie, Betty L., 665 Fikes, John, 997 Knipe, David M., 960 Pomerantz, Betsy J., 925 Zezulak, Kathleen M., 741 Fisher, P. B., 731 Koch, Werner, 828 Ponzetto, Antonio, 701 Zimmermann, Wolfgang, 828 AUTHOR INDEX VOLUME 49

Abramczuk, Jan, 540 Copeland, Neal G., 437 Gerin, John L., 701 Karamata, Dimitri, 806 Amati, Paolo, 566 Costa, R. H., 287 Gilboa, Eli, 686 Kashmiri, S. V. S., 583 Anderson, Carl W., 692, 873 Cote, Paul J., 701 Gilden, Raymond V., 615 Kates, Joseph R., 459 Anderson, Steven M., 881 Couez, Dominique, 615 Ginsberg, H. S., 731 Kato, Shiro, 1014 Arsenakis, Minas, 813 Courtney, Richard J., 594 Giordano, Roberto, 566 Katz, Richard A., 557 Aschman, Doris P., 236 Crawford, Sarah, 909 Girard, M., 717 Kay, Alan, 782 Auer, Bernhard, 588 Crowell, Richard L., 635 Gloor, Greg, 621 Keller, Beat, 902 Cummings, Ian W., 276 Glorioso, Joseph C., 947 Kettmann, Richard, 615 Cywinski, Anita, 200 Goff, Stephen P., 909, 918 Kew, Olen M., 873 Babiss, Lee E., 731 Czarniecki, Christine W., 490 Goldberg, Barbara, 635 Khoury, George, 183 Bacchetti, S., 591 Goldin, Alan L., 947 Kieff, Elliott, 413 Bacchetti, Silvia, 162 Golini, Fred, 459 Klessig, Daniel F., 35 Bakker, Anke, 343 Dailey, Lisa, 984 Golub, E., 102 Knipe, David M., 960 Balce-Directo, L., 279 Daillie, J., 626 Goorha, Rakesh, 86 Knowles, Barbara B., 540 Baltimore, David, 269, 686 Dambrine, G., 325 Gope, Rajalakshmi, 293 Knust, Elisabeth, 363 Banerjee, Papiya T., 319 Darai, G., 609 Gordon, Marc L., 918 Koch, Werner, 828 Barisas, B. George, 980 Davis, Nancy L., 303 Gourlie, Brian B., 333 Kohler, Martin, 658 Basilico, Claudio, 984 DeBorde, Dan C., 418 Graham, Dale E., 819 Kolakofsky, Daniel, 680 Bates, Robert C., 315, 319, 652 DeClercq, Erik, 205 Graham, Frank L., 162 Kozak, Christine, 297, 1005 Bauer, William R., 1 Delius, H., 609 Granoff, Allan, 86 Krauss, Marc R., 333 Bayne, Marvin L., 333 Delli Bovi, Pasquale, 566 Graves, Michael, 409 Krystal, Mark, 418 Beckson, Mace, 881 DeLucia, Angelo L., 9 -Gregoriades, A., 229 Kuhn, Andreas, 902 Bedigian, Hendrick G., 437 Deschamps, Jaqueline, 615 Griffin, Diane E., 349, 409 Beigel, Michel, 1009 De Simone, Vincenzo, 566 Grose, Charles, 992 Bellini, William J., 988 de Soriano. Imelda Lindo, 409 Grubman, Marvin J., 760 Labedan, Bernard, 273 Benatre, A., 325 Desrosiers, Ronald C., 343, 938 Gruss, Peter, 183 Lai, Ching-Juh, 223 Benbow, Robert M., 333 de The, G., 626 Gunnell, Mark A., 297 Laimins, Laimonis A., 183 Ben-Porat, Tamar, 970 de Turenne, M., 626 Langer, Charlotte A., 701 Berk, Arnold J., 132 Dezelee, P., 325 Lederman, Muriel, 315 Bestwick, Richard K., 394 Dietzschold, B., 102 Halbert, Donald N., 692 Lerner, Teena L., 549 Bizub, Diane, 557 Drexler, Henry, 754 Hanafusa, Hidesaburo, 549, 881 Leuther, Michael D., 980 Blank, Kenneth J., 14 Dudley, Jaquelin, 92 Hanggi, Markus, 371 Levine, Arnold J., 692 Blankenhorn, Elizabeth P., 14 Durban, Elisa, 841 Hassell, John A., 925 Levine, Myron, 947 Blankenship, Mayme Lee, 970 Hays, William W., 604 Lewton, Betsy A., 9 Boettiger, David, 841 Hearing, Patrick, 692 Lomniczi, Bela, 970 Boeye, A., 1002 Eckhart, Walter, 799 Heller, Knut J., 20 London, William, 848 Ehrlich, Melanie, 674 Henning, Roland, 658 Long, D., 102, 287 Bouck, Noel, 997 Eisenberg, R., 287 Bouloy, M., 717 Herr, Winship, 471 Long, Deborah, 265 Branton, Philip E., 162 Eisenberg, R. J., 102 Hess, Jay, 349 Low, Robert L., 178 Eisenberg, Roselyn J., 265 Hiller, Gerhard, 371 Lowy, Douglas R., 601 Braun, Daniel K., 142 Ellis, Ronald W., 601 Brow, Mary Ann D., 579 Hirai, Kanji, 1014 Loyter, Abraham, 1009 Brown, Arthur, 379 Engle, Ronald E., 701 Hirsch, Robert L., 409 Esnault, E., 325 Hogue-Angeletti, Ruth, 265 Brown, Dale D., 1018 490 Bryniok, Dieter, 20 Estell, David A., Holland, John J., 793 Maassab, H. F., 418 Evans, Leonard H., 772 Holland, Louis E., 947 Machida, Curtis A., 394 Buonagurio, Deborah A., 418 M. 591 Burghoff, Robert L., 343 Evelegh, J., Honnen, William J., 452 Mackett, Michael, 857 Burny, Arsene, 615 Horisberger, Michel A., 709 Maeder, Marlies, 892, 902 Butel, Janet S., 50 Faller, Douglas V., 269 Horodyski, Frank M., 793 Maeno, Koichiro, 598 Fanning, Thomas G., 66 Hu, Shiu-Lok, 604 Mahr, Anna, 497, 510 Faust, Emanuel A., 621 Hu, Wei-Shau, 66 Mandart, Elisabeth, 782 Calenoff, Miriam, 262 Fennie, Christopher W., 490 Huang, Yung T., 572 Mangel. Walter F., 445 Callahan, Robert, 1005 Ferrer, Jorge F., 583 Hummel, Mary, 413 Maniloff, Jack, 283 Calothy, G., 325 Fields, Bernard N., 641 Huszar, D., 591 Margolskee, Robert F., 386 Cardiff, Robert D., 66 Fikes, John, 997 Mark, George E., 530 Carter, V. Celeste, 766 Fisher, P. B., 731 Markarian, K., 229 Champoux, James J., 686 Fleckenstein, Bernhard, 109, 363, Ikuta, Kazuyoshi, 1014 Markoff, Lewis J., 223 Chejanovsky, Nor, 1009 938 Innis, Michael A., 629 Maruyama, Kazuo, 479 Christie, T., 229 Fligel, R. M., 609 Isom, Harriet C., 426 Maul, Gerd, 540 Clark, B. R., 279 Foglesong, P. David, I Mauel, Catherine, 806 Clements, Janice, 349 Freshney, Mary, 253 McDougall, James K., 109, 363 Cloyd, Miles W., 772 Friedrich, Roland, 828 Jahn, Gerhard, 109, 363 McFarland, Henry F., 988 Coen, Donald M., 236 Friedrichs, William E., 992 Jasmin, Claude, 253 McFarlin, Dale E., 988 Cohen, G., 287 Friesen, Paul D., 116 Jenkins, Nancy A., 437 McKeever, Paul E., 848 Cohen, G. H., 102 Fukui, Yasuhisa, 154 Jennings, Stephen R., 766 Medina, Daniel, 819 Cohen, Gary H., 265 Johnson, Richard T., 409 Mehdi, Rafia, 583 Cole, Michael D., 171 Jones, Elaine V., 72 Meyer, Thomas, 709 Colicelli, John, 918 Galibert, Francis, 782 Jullien, P., 325 Miller, A. Dusty, 214 Collins, Peter L., 572 Gallahan, Daniel, 1005 Miller, Nancy R., 848 Compton, Teresa, 594 Galloway, Denise A., 109, 724 Mitra, Sankar, 319 Concannon, Patrick, 276 Gao, Min, 426 Kaariainen, Leevi, 403 Monroe, Stephan S., 865 Condit, Richard C., 125 Gelep, Paul T., 236 Kabat, David, 394 Montenarh, Mathias, 658 Cook, K. Anne, 57 Gentsch, Jon R., 641 Kamine, James, 343 Moss, Bernard, 72, 857 ii AUTHOR INDEX J. VIROL.

Muirhead, B., 591 Rafield, Lori F., 960 Sheffer, Darlene, 349 Vaisberg, Abraham, 409 Muller, Ingrid, 938 Ramig, Robert F., 665 Shenk, Thomas, 692 van Wyke, Kathleen L., 248 Murphy, Brian R., 248 Rapp, Fred, 205 Shen-Ong, Grace L. C., 171 Varmuza, Susannah L., 356 Rapp, Ulf R., 297, 530 Shenoy, Suresh, 674 Varrichio, A., 102 Ray, Dan S., 178 Shimojo, Hiroto, 154 Vehmeyer, Katalin, 253 Narayan, Opendra, 349 Reagan, Kevin J., 635 Shinomiya, Tomoyuki, 310 Verma, Inder M., 214 Nathans, Daniel, 386 Reck, Linda J., 248 Shiroki, Kazuko, 154 Vialat, P., 717 Nelson, Jay A., 109, 363 Renz, Christopher, 262 Skalka, Anna Marie, 557 Vrijsen, R., 1002 Nichol, Stuart T., 793 Retondo, Margaret J., 236 Smiley, James R., 356 Nishiyama, Yukihiro, 598 Rice, Patricia L., 766 Smith, Geoffrey L., 857 Nunberg, Jack H., 629 Rice, Stephen A., 35 Smith, Gilbert H., 819 Risser, Rex, 92 Smith, Julie K., 200 Roberts, Bryan E., 125, 497, 510 Snyder, Cathy E., 319 Wagner, E., 287 Oda, Kinichiro, 479 Robertson, Alice T., 652 Spear, Patricia G., 741 Walker, Duard L., 848 O'Hara, Patrick J., 793 Roedenbeck, Susi, 409 Spindler, Katherine R., 132 Wallen, William C., 848 Oker-Blom, Christian, 403 Roizman, Bernard, 142, 813 Sridhar, P., 125 Wang, Lu-Hai, 881 Oliff, Allen, 828 Rombaut, B., 1002 Steffensen, Dale M., 445 Wang, Richard Y.-H., 674 Omilianowski, Daniel R., 873 Rose, John W., 988 Stenberg, Richard M., 190 Watanabe, Sumie, 78 Ooka, T., 626 Rosenthal, Ken S., 980 Stephens, Robert M., 615 Weissbach, Arthur, 26 Ostertag, Wolfram, 253 Rosser, Debra S. E., 132 Stewart, Charles R., 300 Weller, Sandra K., 236 Rowe, David T., 162 Stinski, Mark F., 190 Wertz, Gail W., 303, 572 Rueckert, Roland R., 116, 873 Stout, Ernest R., 315, 652 Wigdahl, Brian, 205, 426 Rundell, Kathleen, 262 Strathearn, Michael D., 178 Wilhelmsen, Kirk C., 521 Padgett, Billie L., 848 Rundell, M. Kathleen, 997 Sutcliffe, J. Gregor, 579 Williams, Bryan R. G., 748 Palese, Peter, 418 Rutter, Gabriel, 253 Sveda, Michael M., 223 Williams, Mark E., 629 Pallansch, Mark A., 873 Swain, Margaret A., 724 Willis, Dawn B., 86 Pan, Sueihua, 540 Willumsen, Berthe M., 601 Pardigon, N., 717 Wimmer, Eckard, 873 Patterson, Jean L., 680 Wing, David, 26 315 Patton, John T., 303, Saito, Izumu, 154 Taylor, John M., 200 Wittek, Riccardo, 371 Pellegrini, Sandra, 984 Salser, Winston A., 276 Wolcott, Judith A., 379 J. 748 Tegtmeyer, Peter, 9 Penn, Linda Z., Salzman, Lois A., 1018 Temin, Howard M., 521 Wolfe, John H., 14 Pereira, L., 102 Sandri-Goldin, Rozanne M., 947 Wust, Carl J., 379 142 Templeton, Dennis, 799 Pereira, Lenore, Santos, Myriam, 50 Tevethia, Satvir S., 766 Petrie, Betty L., 665 Sarnow, Peter, 692 Ralf 403 Thomas, Christopher Y., 437 Pettersson, F., Sarre, Thomas, 363 Thomsen, Darrell R., 190 Pinter, Abraham, 452 Sartori, C. S., 591 Saibal K., 283 Thorley-Lawson, David, 413 Poddar, Schaffer, Priscilla A., 236 Ting, Y.-P., 279 Yee, Sui-Pok, 162 Poirier, F., 325 Scheck, Adrienne C., 205 Yewdell, Jonathan W., 248 Betsy J., 925 Traktman, Paula, 125 Pomerantz, Schirm, Sabine, 938 Traub, Franz, 892, 902 Yogo, Yoshiaki, 78 Ponce de Leon, M., 102 Schlesinger, Sondra, 865 Yoshida, Shonen, 598 Ponzetto, Antonio, 701 Schmolla, Henrik, 363 Yoshiike, Kunito, 78 Potts, Diane E., 604 Schwartzberg, Pamela, 918 Powers, David B., 490 Schweiger, Manfred, 588 Pozzatti, Rudy, 183 Scolnick, Edward M., 601 Udem, Stephen A., 57 Zaia, J. A., 279 Semler, Bert L., 873 Ueda, Shigeharu, 1014 Zezulak, Kathleen M., 741 Sen, Arup, 579 Uhlenbeck, Olke C., 445 Ziegler, Richard J., 205 Rabin, Mark, 445 Serwer, Philip, 293 Ulmanen, Ismo, 403 Zimmermann, Wolfgang, 828 SUBJECT INDEX VOLUME 49

Adenovirus 0 T4 12 bacteriophage T5, 20 cross-linking, 902 transformation-defective, replication- small-t prohead core formation in vivo, 892 nondefective early region IB mu- simian 40, 262 prohead core isolation, 902 tants, 154 surface composition, 902 S woodchuck hepatitis virus, 701 T5 cold-sensitive phenotype for transfor- T 0 -dependent mutant, 20 mation, 731 simian virus 40, 386 Black beetle virus defective phenotype for transforma- tumor early and late functions tion, 731 adenovirus, 692 translational control by competition deletion mutations, 731 Aphidicolin between viral mRNAs, 116 early region la deletion mutations, inhibition of bovine parvovirus replica- Bovine adenovirus 731 tive-form DNA, 652 sequence homology with human adeno- early region la insertion mutations, ATP virus, 604 731 effects on virus type I topoiso- Bovine leukemia virus hamster lines, 162 merase activity, I covalently closed circular DNA insertion mutations, 731 Avian myeloblastosis virus molecular cloning, 583 restriction endonuclease fragments, embryonic yolk sac integrated provirus DNA long terminal 162 relationship of cell differentiation to repeat transformation, 731 cell transformation, 841 nucleotide sequence analysis, 615 DNA-binding protein target cells, 841 viral and host sequences adjacent to viral late , 35 long terminal repeat early region 4 RNA primer removal, 686 nucleotide sequence analysis, 615 25,000-dalton protein, 692 RNase H activity, 686 Bovine parvovirus early region IB 58,000-dalton tumor target cells aphidicolin antigen, 692 embryonic yolk sac, 841 inhibition of replicative-form DNA, productively infected cells, 692 relationship of cell differentiation to 652 early region IA cell transformation, 841 replicative-form DNA transforming , 132 Avian inhibition by aphidicolin, 652 early region IB virally coded noncapsid protein, 315 58,000-dalton tumor antigen, 692 plus-strand DNA synthesis, 200 early region 4 25,000-dalton protein, reverse , 200 692 Avian sarcoma virus Caprine arthritis-encephalitis lentivirus productively infected cells, 692 recovered immunization transforming proteins, 132 viral sequence required for genera- inactivated M. tuberculosis, 349 productively infected cells tion, 881 M. tuberculosis early region IB 58,000-dalton tumor replication-defective recovered, 881 immunization, 349 antigen, 692 neutralizing antibodies, 349 early region 4 25,000-dalton protein, Bacillus subtilis persistently infected goats, 349 692 mitomycin C neutralizing antibodies transforming proteins proteins, 806 immunization with inactivated M. tu- early region IA, 132 proteins berculosis, 349 early region IB, 132 mitomycin C, 806 persistently infected goats, 349 E. coli fusion , 132 Bacteriophage persistently infected goats viral DNA replication, 35 ,X174 immunization with inactivated M. tu- AKV DNA methylation, 674 berculosis, 349 nucleotide sequence, 471 DNA single-strand initiation determi- neutralizing antibodies, 349 Antibody nant, 178 Cell lines virus, 409 replicative-form DNA, 178 hamster monoclonal transfecting activity of replicative- adenovirus 5, 162 herpesvirus of turkeys, 1014 form DNA, 674 lymphoid A virus, 248 x H. saimiri, 938 Marek's disease virus, 1014 initiation of DNA packaging by bacte- transformed hybrid neutralizing riophage Tl, 754 simian virus 40, 445 caprine arthritis-encephalitis lenti- P gene, 754 tumor virus, 349 Q gene, 754 derived from H-2 congenic mice, 14 virus, 102 P22 Gross virus-induced, 14 nonneutralizing, monoclonal with subgenome length of Cells , 1002 packaged DNA, 293 Friend erythroleukemic Antigen PS17 polyomavirus growth and persis- fusion P. aeruginosa PAO, 310 tence, 566 E. coli, 132 pyocin R2, 310 HeLa , 102 SPOI infected nuclei, 26 influenza A virus, 248 double mutant HA20, 300 vaccinia virus RNA polymerase, 26 large T Tl human peripheral blood mononuclear polyomavirus, 925 bacteriophage X P gene, 754 influenza virus vaccine, 748 simian virus 40, 658, 925, 997 bacteriophage X Q gene, 754 , 748 large tumor initiation of bacteriophage X DNA rubella virus vaccine, 748 simian virus 40, 50 packaging, 754 2-SA synthetase activity, 748 iii iv SUBJECT INDEX J. VIROL.

nonproducer Raji 12-O-tetradecanoylphorbol- 13-ace- p30-related proteins DNase, 626 tate treatment, 626 H-2 congenic mice, 14 Epstein-Barr virus, 626 envelope tumor cell lines, 14 rat 3Y1 encoding of messages by DNA frag- tumor cell lines human papovavirus BK, 78 ment, 413 p30-related proteins, 14 rhabdomyosarcoma 4p220/200, 413 Guinea pig cytomegalovirus coxsackievirus B3, 635 Zp350/300, 413 characterization of DNA, 426 T nonproducer Raji cells endogenous mouse mammary tumor DNase activity, 626 virus , 92 sodium butyrate treatment, 626 Hamsters mouse lymphomas, 92 12-O-tetradecanoylphorbol- 13-ace- cell lines target tate treatment, 626 adenovirus 5, 162 avian myeloblastosis virus, 841 sodium butyrate treatment Harvey murine sarcoma virus embryonic yolk sac, 841 DNase activity, 626 p21 v-ras gene herpes simplex virus type 2, 766 nonproducer Raji cells, 626 transforming sequences, 601 lysis by herpes simplex virus-specific 12-O-tetradecanoylphorbol- 13-acetate Hemagglutinin cytotoxic T lymphocytes, 766 treatment influenza virus relationship of cell differentiation to DNase activity, 626 altered hydrophobic carboxy termi- cell transformation, 841 nonproducer Raji cells, 626 nus, 223 transformed Escherichia coli intracellular accumulation, 223 simian virus 40, 50 fusion antigens influenza virus A/USSR/90/77 transformed mouse adenovirus transforming proteins, 132 gene nucleotide sequence, 276 reversion, 479 interferon Herpes simplex virus simian virus 40, 479 human alpha, 490 Chromosomes human beta, 490 DNA binding, 813 mouse 12 human gamma, 490 host protein, 813 BALB/c, 1005 synergistic antiviral and antiprolifera- post-a gene function, 813 mouse mammary tumor virus, 1005 tive activities, 490 antigenic determinant mouse 6 Escherichia coli virus D, 102 BALB/c, 1005 TI binding c-rafoncogene, 297 DNA methyltransferase, 588 modulation of cell surface protein mo- mouse mammary tumor virus, 1005 bility, 980 Coliphage capsids T5 Feline leukemia virus gene 35 protein binding, 142 fluid host cell membrane, 273 subgroup B cell surface protein mobility Coxsackievirus envelope gene nucleotide sequence, modulation by viral binding, 980 B3 629 modulation by viral entry, 980 altered receptor specificity, 635 Fibroblasts DNA diploid region rhabdomyosarcoma cells, 635 human diploid unstable heterozygosity, 356 herpes simplex virus genome, 205 DNA polymerase locus Foot-and-mouth disease virus fine mapping of mutations, 236 Defective-interfering particles in vitro morphogenesis, 760 molecular cloning of mutations, 236 vesicular stomatitis virus Friend mink cell focus-inducing virus entry resistant mutants, 793 envelope gene modulation of cell surface protein mo- Dithiothreitol molecular analysis, 828 bility, 980 Sendai virus long terminal repeat gene 35 proteins dissociation of adsorbed virus parti- molecular analysis, 828 binding to full surfaces, 142 cles from cell membranes, 1009 Friend murine leukemia virus nonbinding to empty capsid surfaces, DNase dual-tropic 142 Epstein-Barr virus, 626 gp7O specific domains, 452 post-translational products, 142 nonproducer Raji cells, 626 ecotropic genome Duck gp7O specific domains, 452 human diploid fibroblasts, 205 cloned genome mink cell focus-forming viruses in vitro latency, 205 comparison of nucleotide sequence recombination with specific endoge- rat sensory neurons, 205 with human hepatitis B virus se- nous proviral sequences, 772 glycoprotein D quence, 782 Frog virus 3 antigenic determinant, 102 comparison of nucleotide sequence DNA methyltransferase, 86 neutralizing antibody, 102 with woodchuck hepatitis B virus neutralizing antibody sequence, 782 glycoprotein D, 102 nucleotide sequence, 782 Germiston bunyavirus type 1 S segment transcript DNA-binding protein ICP8, 960 coding for nonstructural protein, 717 genetic analysis of genome, 947 Encapsidation coding for nucleoprotein, 717 glycoprotein B, 960 autonomous parvovirus LuIll uncapped, 717 glycoprotein C, 741 minus-strand DNA, 319 Goats glycoprotein D amino-terminal se- plus-strand DNA, 319 caprine arthritis-encephalitis lentivirus quence, 265 Epstein-Barr virus immunization, 349 herpes simplex virus type 2 glycopro- DNA fragment immunization tein C counterpart, 741 envelope glycoprotein gp220/200, 413 caprine arthritis-encephalitis lenti- herpes simplex virus type 2 mutant envelope glycoprotein gp350/300, 413 virus, 349 not expressing glycoprotein C, DNase activity Gross virus 741 nonproducer Raji cells, 626 H-2 congenic mice 6-kilobase mRNA, 287 sodium butyrate treatment, 626 p30-related proteins, 14 major capsid protein VP5, 287 VOL. 49, 1984 SUBJECT INDEX v

major mRNAs, 960 altered hydrophobic carboxy termi- owl monkeys, 848 nuclear fractions, 594 nus, 223 owl monkeys polypeptides, 591 intracellular accumulation, 223 brain tumors, 848 transcriptional analysis of genome, interferon 947 macrophages, 709 viral ribonucleotide reductase activi- mouse a, 709 Kilham rat virus ty, 591 mouse 1, 709 structural proteins virus-specific glycoproteins, 594 resistance gene Mx, 709 sequency homology, 1018 type 2 macrophages Kinase BglII N fragment, 724 mouse a interferon, 709 p6OSrc cytotoxic T lymphocytes, 766 mouse a interferon, 709 tumor formation, 325 glycoprotein D amino-terminal se- resistance gene Mx, 709 quence, 265 membrane protein herpes simplex virus type I glycopro- phosphoprotein, 229 La Crosse virus tein C, 741 two forms, 229 small-genome transcripts, 680 mutant not expressing glycoprotein mouse a interferon Ligase C, 741 macrophages, 709 polyomavirus minichromosomes, 333 polypeptides, 591 resistance gene Mx, 709 Liposomes structural gene mapping, 741 mouse 13 interferon encapsulation target cell susceptibility to lysis, 766 macrophages, 709 retrovirus, 269 viral ribonucleotide reductase activi- resistance gene Mx, 709 Lymphocytes ty, 591 resistance gene Mx cytotoxic T UV-irradiated macrophages, 709 herpes simplex virus type 2, 766 DNA polymerase a, 598 mouse a interferon, 709 lysis of herpes simplex virus-infected host cell reactivation, 598 mouse 1 interferon, 709 target cells, 766 Herpesvirus vaccine Lymphomas turkeys human peripheral blood mononuclear mouse T-cell glycoproteins, 1014 cells, 748 endogenous mouse mammary tumor monoclonal antibodies, 1014 interferon, 748 virus genomes, 92 virus neutralization, 1014 2-SA synthetase activity, 748 Herpesvirus saimiri Insect iridescent virus in vitro transformation 6 Macrophages lymphoid cell line, 938 circular permutation, 609 influenza virus lymphoid cell line terminal redundancy, 609 resistance gene Mx, 709 in vitro transformation, 938 Interferon resistance gene Mx replication-competent deletion mutants, E. coli-derived influenza virus, 709 343 human alpha, 490 Mammalian reovirus Host cell reactivation human beta, 490 bovine herpes simplex virus, 598 human gamma, 490 tryptic peptide analysis of outer cap- Human adenovirus synergistic antiviral and antiprolifera- sid polypeptides, 641 sequence homology with bovine adeno- tive activities, 490 genetic diversity in natural populations, virus, 604 human alpha 641 Human cytomegalovirus E. coli-derived, 490 human type 1 AD169 synergistic antiviral and antiprolifera- tryptic peptide analysis of outer cap- immediate-early transcripts, 363 tive activities, 490 sid polypeptides, 641 transforming region, 109 human beta human type 3 64,000-dalton glycoprotein, 279 E. coli-derived, 490 tryptic peptide analysis of outer cap- major immediate early gene, 190 synergistic antiviral and antiprolifera- sid polypeptides, 641 Human hepatitis B virus tive activities, 490 murine nucleotide sequence human gamma tryptic peptide analysis of outer cap- comparison with cloned duck hepati- E. coli-derived, 490 sid polypeptides, 641 tis B virus genome nucleotide se- synergistic antiviral and antiprolifera- Marek's disease virus quence, 782 tive activities, 490 glycoproteins Human papovavirus influenza virus vaccine monoclonal antibodies, 1014 BK human peripheral blood mononuclear virus neutralization, 1014 rat 3YI cells, 78 cells, 748 monoclonal antibodies viral early functions, 78 2-SA synthetase activity, 748 glycoproteins, 1014 Hybridization mouse a virus neutralization, 1014 in situ influenza virus, 709 virus neutralization simian virus 40, 445 macrophages, 709 glycoproteins, 1014 resistance gene Mx, 709 monoclonal antibodies, 1014 mouse 13 Measles virus Influenza virus influenza virus, 709 antibody A macrophages, 709 polypeptides, 409 antigen, 248 resistance gene Mx, 709 complicated infections, 409 matrix protein, 248 rubella virus vaccine intracellular nucleocapsid RNA, 57 monoclonal antibodies, 248 human peripheral blood mononuclear polypeptides mutant with deletion in NS segment, cells, 748 antibody, 409 418 2-SA synthetase activity, 748 human cellular immune response, 988 A/USSR/90/77 uncomplicated infections, 409 hemagglutinin gene nucleotide se- Methylation quence, 276 JC virus bacteriophage 4X174 replicative-form hemagglutinin brain tumors DNA vi SUBJECT INDEX J. VIROL.

transfecting activity, 674 pMLV-I noninfectious molecular clone mouse chromosome 6, 297 mouse mammary tumor virus proviral restoration of infectivity, 214 c-rel (turkey) DNA, 66 reverse transcriptase reticuloendotheliosis virus strain T, Methyltransferase gag gene mutations, 918 521 DNA virions structure and dimorphism, 521 E. coli virus Tl, 588 gag gene mutations, 918 frog virus 3, 86 Moloney murine sarcoma virus Mice long terminal repeat Parvovirus BALB/c enhancer elements, 183 endogenous LullI chromosomes 6 and 12, 1005 Monkeys minus-strand DNA encapsidation, mouse mammary tumor virus, 1005 owl 319 chromosome 6 brain tumors, 848 plus-strand DNA encapsidation, 319 c-raf , 297 JC virus, 848 Plasmacytoma C3H/Sm Mouse mammary tumor virus mouse mouse mammary tumor virus, 819 BALB/c mice intracisternal A-particle genes, 171 H-2 congenic chromosomes 6 and 12, 1005 Poliovirus Gross virus, 14 genomes, 1005 nonneutralizing, monoclonal antibodies tumor cell lines, 14 C3H/Sm mice intertypic cross-reactions, 1002 a interferon indigenous proviral long terminal re- protein processing map, 873 influenza virus, 709 peat-containing transcript, 819 Polymerase macrophages, 709 endogenous DNA resistance gene Mx, 709 amplification of genomes, 92 herpes simplex virus, 236 a interferon mouse T-cell lymphomas, 92 mapping, 72 influenza virus, 709 novel locations of genomes, 92 transcriptional mapping, 125 macrophages, 709 endogenous ecotropic vaccinia virus, 72, 125 resistance gene Mx, 709 DNA transfection assays, 437 DNA a normal tissues molecularly cloned proviruses, 437 herpes simplex virus, 598 mouse mammary tumor virus, 66 poorly infectious , 437 RNA plasmacytoma genomes infected HeLa cell nuclei, 26 intracisternal A-particle genes, 171 BALB/c mice, 1005 vaccinia virus, 26 simian virus 40 chromosomes 6 and 12, 1005 Polyomavirus tumor induction, 540 indigenous proviral long terminal re- cell transformation T-cell lymphomas peat-containing transcript impaired by deletion at DNA origin of endogenous mouse mammary tumor C3H/Sm mice, 819 replication, 984 virus genomes, 92 increased concentration in C3H/Sm viable mutants cold sensitive for tumor induction mice, 819 maintenance, 799 simian virus 40, 540 neoplastic transformation of mamma- deletion at DNA Minichromosomes ry epithelium in C3H/Sm mice, ability to form tandem insertions im- polyomavirus 819 paired, 984 DNA ligase activity, 333 normal mouse tissues ability to transform cells impaired, DNA topoisomerase II activity, 333 proviral DNA methylation patterns, 984 Mink cell focus-forming murine leukemia 66 DNA li'gase activity virus proviral DNA methylation patterns minichromosomes, 333 endogenous nonecotropic parent normal mouse tissues, 66 DNA topoisomerase II activity gp7O sequence, 530 Mycobacterium tuberculosis minichromosomes, 333 envelope gene sequence, 530 inactivated Friend erythroleukemic cells gp7O sequence caprine arthritis-encephalitis lenti- growth, 566 endogenous nonecotropic parent, 530 virus, 349 persistence, 566 Mink cell focus-forming viruses neutralizing antibodies, 349 growth in Friend erythroleukemic cells, Friend murine leukemia virus persistently infected goats, 349 566 recombination with specific endoge- Mycoplasma virus large T antigen nous proviral sequences, 772 L2 binding to DNA sequences in com- Minute virus of mice novobiocin, 283 mon with those of simian virus 40 metastable, partially replicated dimeric replication, 283 large T antigen, 925 intermediate, 621 Myeloproliferative sarcoma virus minichromosomes Mitogens fibroblast transformation DNA ligase activity, 333 Rous sarcoma virus p6Os'c temperature-sensitive mutants, 253 DNA topoisomerase II activity, 333 tumor formation, 325 hematopoietic transformation persistence in Friend erythroleukemic Mitomycin C temperature-sensitive mutants, 253 cells, 566 B. subtilis proteins, 806 temperature-sensitive mutants tandem insertion formation ml murine sarcoma virus fibroblast transformation, 253 impaired by deletion at DNA origin of transforming gene hematopoietic transformation, 253 replication, 984 nucleotide sequence, 579 viable mutants Moloney murine leukemia virus cold sensitive for maintenance of cell gag gene mutations Neurons transformation, 799 effects on reverse transcriptase, 918 rat sensory Pseudomonas aeruginosa effects on virions, 918 herpes simplex virus genome, 205 PAO gag protein P12 mutations Novobiocin bacteriophage PS 17, 310 blocking of early stages of infection, mycoplasma virus L2 replication, 283 pyocin R2, 310 909 Pseudorabies virus gag protein P15 mutations vaccine strains blocking of early stages of infection, deletions in genomes, 970 909 c-raf four isomers of genomes, 970 VOL. 49, 1984 SUBJECT INDEX vii

Pyocin tumor formation small-t antigenri R2 p60Src kinase activity, 325 reversal of theophylline resistance, bacteriophage PS 17, 310 p605Sc mitogenic property, 325 262 P. aeruginosa PAO, 310 Rubella virus T antigens 40S genome RNA mutant, 386 precursor to structural proteins, 403 relaxed specificity for viral DNA ori- Radioimmunoassays 24S subgenomic RNA, 403 gin of replication nucleotide se- site-specific structural proteins quence, 386 woodchuck hepatitis virus surface precursor, 403 viral DNA origin of replication nucle- antigen, 701 vaccine otide sequence, 386 Rats human peripheral blood mononuclear transformed cell surfaces 3YI cells cells, 748 , 50 human papovavirus BK, 78 interferon, 748 cellular protein, 50 Rauscher spleen focus-forming virus 2-SA synthetase activity, 748 transformed hybrid cell lines membrane glycoprotein mutations in situ hybridization, 445 reduced leukemogenicity, 394 transformed mouse cells reduced leukemogenicity Sendai virus reversion, 479 membrane glycoprotein mutations, adsorbed virus particles tumor induction 394 cell membranes, 1009 immune response of host, 540 Receptors dissociation with dithiothreitol, 1009 long-term persistence of viral coxsackievirus B3, 635 cell membranes genome, 540 Respiratory syncytial virus adsorbed virus particles, 1009 mice, 540 assignment of polypeptides to 10 viral dithiothreitol Sindbis virus genes, 572 dissociation of adsorbed virus parti- defective-interfering tenth mRNA, 572 cles, 1009 common regions, 865 Restriction endonuclease Serial affinity chromatography distinct regions, 865 adenovirus 5 fragments, 162 varicella-zoster virus glycoprotein El glycoprotein BgII gp 18, 992 immunologically cross-reactive pro- herpes simplex virus type 2 N frag- Simian SAII teins, 379 ment, 724 temperature-sensitive mutants unique conformation, 379 EcoRI morphogenesis, 665 immunologically cross-reactive proteins 7. 1-kilobase fragment, 510 protein synthesis, 665 unique conformation of El glycopro- vaccinia virus DNA fragment, 497, Simian virus 40 tein, 379 510 A protein Sodium butyrate Reticuloendotheliosis virus binding to DNA, 9 Epstein-Barr virus strain T chromosomal sites of integration DNase activity, 626 c-rel (turkey) structure and dimor- DNA sequences, 445 2-SA Synthetase phism, 521 cold-sensitive transformant influenza virus vaccine oncogene, 521 large-T-antigen-p53 complex, 997 human peripheral blood mononuclear Retrovirus mutant tsA1499, 997 cells, 748 liposome encapsulation DNA interferon, 748 efficient superinfection of resistant binding to A protein, 9 rubella virus vaccine cell lines, 269 deletions at origin of replication, 9 human peripheral blood mononuclear Reverse transcriptase DNA sequences cells, 748 avian myeloblastosis virus chromosomal sites of integration, 445 interferon, 748 RNA primer removal, 686 in situ hybridization RNase H activity, 686 transformed hybrid cell lines, 445 Moloney murine leukemia virus integrated viral sequences 12-O-Tetradecanoylphorbol- 13-acetate gag gene mutations, 918 two types of deletion, 479 Epstein-Barr virus Ribonucleotide reductase large T antigen DNase activity, 626 herpes simplex virus type 1 polypep- binding to DNA sequences in com- Theophylline tides, 591 mon with those of polyomavirus simian virus 40 small-t antigen herpes simplex virus type 2 polypep- large T antigen, 925 reversal of resistance, 262 tides, 591 oligomerization, 658 Topoisomerase RNase H temperature-sensitive A gene lesions, type I avian myeloblastosis virus reverse tran- 658 effects of ATP, I scriptase large-T-antigen-p53 complex vaccinia virus, I RNA primer removal, 686 cold-sensitive transformant, 997 type II Rous-associated virus-2 mutant tsA1499, 997 polyomavirus minichromosomes, 333 noncoding regions large tumor antigen Turkeys conserved regions important in repli- transformed cell surfaces, 50 herpesvirus cation and oncogenesis, 557 mice glycoproteins, 1014 nucleotide sequence, 557 immune response of host, 540 monoclonal antibodies, 1014 Rous sarcoma virus long-term persistence of viral virus neutralization, 1014 Bryan high-titer strain genome, 540 DNA sequence, 549 tumor induction, 540 UV irradiation extent of deletion, 549 mutant tsA 1499 herpes simplex virus genealogical relationship with other cold-sensitive transformant, 997 DNA polymerase a, 598 strains, 549 large-T-antigen-p53 complex, 997 host cell 598 p6Orc kinase activity p53 cellular protein reactivation, tumor formation, 325 transformed cell surfaces, 50 p60sr mitogenic property reversal of theophylline resistance Vaccine tumor formation, 325 small-t antigen, 262 influenza virus viii SUBJECT INDEX J. VIROL.

human peripheral blood mononuclear infected HeLa cell nuclei accumulation offew 3'-terminal muta- cells, 748 RNA polymerase, 26 tions, 793 interferon, 748 inhibitory factors accumulation of stable 5'-terminal 2-5A synthetase activity, 748 effects on activi- mutations, 793 rubella virus ty, 1 resistant to defective-interfering parti- human peripheral blood mononuclear recombinants cles, 793 cells, 748 expressing foreign genes, 857 N protein interferon, 748 RNA polymerase protein synthesis, 303 2-SA synthetase activity, 748 infected HeLa cell nuclei, 26 RNA replication, 303 Vaccinia virus type I topoisomerase activity protein synthesis ATP effects of ATP, 1 N protein, 303 effects on type I topoisomerase activi- effects of inhibitory factors, 1 RNA replication, 303 ty, 1 Varicella-zoster virus RNA replication DNA polymerase gene glycoprotein gpl 18 N protein, 303 transcriptional mapping, 125 purification by serial affinity chroma- protein synthesis, 303 DNA polymerase gene mapping tography, 992 cell-free of RNA, 72 serial affinity chromatography marker rescue, 72 glycoprotein gpl 18, 992 Woodchuck hepatitis virus EcoRI DNA fragment Vesicular stomatitis virus nucleotide sequence 7.1 kilobases, 510 defective-interfering particles comparison with cloned duck hepati- late RNAs, 510 accumulation offew 3'-terminal muta- tis B virus genome nucleotide se- six early transcripts, 497 tions, 793 quence, 782 genome accumulation of stable 5'-terminal site-specific radioimmunoassays early region, 459 mutations, 793 surface antigen, 701 mapping of gene coding for major late resistant mutants, 793 surface antigen structural polypeptide, 371 mutants site-specific radioimmunoassays, 701 Announcing a major new emphasis and broadening of the scope of Journal of Virology to include the expanding and important area of VIRAL PATHOGENESIS AND IMMUNITY

A major change to the Journal of Virology is being implemented. Starting in January 1984, JVI will publish a major new section on viral pathogenesis and immunity. To help accomplish this change, two new editors of JVI have been appointed. They are Bernard N. Fields and Michael B. A. Oldstone. Edward M. Scolnick continues as Editor in Chief. Scope Statement for New Section The major scope of this new section will be the interaction of viruses with eucaryotic organisms. Among the fields that will be appropriate for publication in the new section are those aspects of virology that include experimental viral pathogenesis (including entry into the host, spread within the host, tropism to target tissues, and cellular injury) as well as the nature of the immune response (nonspecific andl specific; cellular and humoral). In addition, such related areas as the nature of the viral receptors on host cells, determinants of tissue pathology, genetics of the host related to viral infections, and the physiology of the host as altered by viral infection will be included. Submission of Manuscripts Manuscripts should be submitted to: ASM Publications Office, 1913 I Street, NW, Washington, DC 20006, USA. Subscriptions Joumal of Virology is published monthly, approximately 4,500 printed pages a year. Members of ASM may subscribe for $37.00 per year (U.S.); $49.00 (foreign). The nonmember subscription rate is $249.00. All payments must be made in advance of subscription service and must be in U.S. dollars, drawn on a U.S. bank located within the continental United States. Price fiSMis subject to change. merican Society for Microbiology American Sodcetv for Microbiology 19131 Street, NW * Washington, DC 20006, U.S.A.