The Functional O-Mannose Glycan on A
RESEARCH ARTICLE The functional O-mannose glycan on a- dystroglycan contains a phospho-ribitol primed for matriglycan addition Jeremy L Praissman1†, Tobias Willer2,3,4,5†, M Osman Sheikh1†, Ants Toi6, David Chitayat7,8,9, Yung-Yao Lin10,11,12, Hane Lee13,14,15, Stephanie H Stalnaker1, Shuo Wang1, Pradeep Kumar Prabhakar1, Stanley F Nelson13,14,15, Derek L Stemple12, Steven A Moore16, Kelley W Moremen1,17, Kevin P Campbell2,3,4,5*, Lance Wells1,17* 1Complex Carbohydrate Research Center, University of Georgia, Athens, United States; 2Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, United States; 3Howard Hughes Medical Institute, University of Iowa, Iowa City, United States; 4Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, United States; 5Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, United States; 6Department of Medical Imaging, Mount Sinai Hospital, Toronto, Canada; 7Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, University of Toronto, Toronto, Canada; 8The Prenatal Diagnosis and Medical Genetics Program, Mount Sinai Hospital, Toronto, Canada; 9Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada; 10Blizard Institute, London, United Kingdom; 11Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; 12Wellcome *For correspondence: kevin- Trust Genome Campus, Wellcome Trust Sanger Institute,
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