Cryonics Magazine, Q3 1998
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Physiology of Highly Radioresistant Escherichia Coli After Experimental Evolution for 100 Cycles of Selection
Lawrence Berkeley National Laboratory Recent Work Title Physiology of Highly Radioresistant Escherichia coli After Experimental Evolution for 100 Cycles of Selection. Permalink https://escholarship.org/uc/item/5bj102bg Authors Bruckbauer, Steven T Martin, Joel Minkoff, Benjamin B et al. Publication Date 2020 DOI 10.3389/fmicb.2020.582590 Peer reviewed eScholarship.org Powered by the California Digital Library University of California fmicb-11-582590 September 17, 2020 Time: 16:43 # 1 ORIGINAL RESEARCH published: 22 September 2020 doi: 10.3389/fmicb.2020.582590 Physiology of Highly Radioresistant Escherichia coli After Experimental Evolution for 100 Cycles of Selection Steven T. Bruckbauer1, Joel Martin2, Benjamin B. Minkoff1,3, Mike T. Veling4, Illissa Lancaster1, Jessica Liu1, Joseph D. Trimarco1†, Brian Bushnell2, Anna Lipzen2, Elizabeth A. Wood1, Michael R. Sussman1,3, Christa Pennacchio2 and Michael M. Cox1* Edited by: Vasco Ariston De Carvalho 1 Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, United States, 2 DOE Joint Genome Institute, Azevedo, Berkeley, CA, United States, 3 Center for Genomic Science Innovation, University of Wisconsin School of Medicine and Public Federal University of Minas Gerais, Health, Madison, WI, United States, 4 Department of Systems Biology, Harvard Medical School, Boston, MA, United States Brazil Reviewed by: Bing Tian, Ionizing radiation (IR) is lethal to most organisms at high doses, damaging every cellular Zhejiang University, China macromolecule via induction of reactive oxygen species (ROS). Utilizing experimental Vera Y. Matrosova, evolution and continuing previous work, we have generated the most IR-resistant Henry M. Jackson Foundation for the Advancement of Military Escherichia coli populations developed to date. After 100 cycles of selection, the Medicine, United States dose required to kill 99% the four replicate populations (IR9-100, IR10-100, IR11- Suzanne Sommer, Université Paris-Saclay, France 100, and IR12-100) has increased from 750 Gy to approximately 3,000 Gy. -
Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law
Journal of Contemporary Health Law & Policy (1985-2015) Volume 2 Issue 1 Article 13 1986 Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law Harold A. Buetow Follow this and additional works at: https://scholarship.law.edu/jchlp Recommended Citation Harold A. Buetow, Medical-Legal Aspects of Cryonics: Prospects for Immortality Ethical - Legal and Social Challenges to a Brave New World Genetics - Ethics and the Law, 2 J. Contemp. Health L. & Pol'y 173 (1986). Available at: https://scholarship.law.edu/jchlp/vol2/iss1/13 This Book Review is brought to you for free and open access by CUA Law Scholarship Repository. It has been accepted for inclusion in Journal of Contemporary Health Law & Policy (1985-2015) by an authorized editor of CUA Law Scholarship Repository. For more information, please contact [email protected]. BOOK REVIEWS MEDICAL-LEGAL ASPECTS OF CRYONICS: PROSPECTS FOR IMMORTALITY. New York City: Associated Faculty Press 1983. Pp. 81. $12.00. ETHICAL, LEGAL AND SOCIAL CHALLENGES TO A BRAVE NEW WORLD. New York City: Associated Faculty Press 2 Vols. 1982. 1 Vol. Pp. 286, $32.00. 2 Vol. Pp. 264, $28.50. GENETICS, ETHICS AND THE LAW. By George P. Smith, II. New York City: Associated Faculty Press, 1981. Pp. 241. $28.50, cloth; $18.50, paper. Reviewed by Harold A. Buetow, M.A., Ph.D., J.D. In 1968, the University of Michigan Law Review published an article enti- tled, "Through A Test Tube Darkly: Artificial Insemination and The Law."' Its author was George P. -
Part I—Write an Obituary Worth Reading
Writing An Obituary Worth Reading A Guide For Writing A Fulfilling Life-Review This Sampler version contains the first half of the book. You can find a complete print copy version at Amazon. Or, you can ask the author for a free digital PDF version in exchange for your donation to the causes listed on the last page entitled I Give, You Give. By Martin Kimeldorf Draft 28 Images for obituaries provided by authors and friends. All other words (not quoted) and images by Martin Kimeldorf. ©.Kimeldorf.2015 Second updating and digital distribution April 3, 2016 SearchInc Press, Tumwater, WA All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means-electronic, mechanical, photocopying, recording, or otherwise without written permission from the author. Write to him at [email protected] Publishing History: First Digital Distribution and copyright in 2015 by Martin Kimeldorf. Publication Data: Kimeldorf, Martin. Writing An Obituary Worth Reading 1. Philosophy 2. Writing Copyright Code TXu 1-967-439 This book is licensed and distributed for your personal enjoyment only. This electronic PDF book version and the print version may not be re-sold, distributed nor given away to other people without the author’s permission. Thank you for respecting my hard work on this book. Other works can be found at www.martinkimeldorf.org. This book is not intended to diagnose, prescribe or treat any ailment, nor is it intended as a replacement for medical, counseling or other professional consultation. The author and publisher strongly suggest that at the first suspicion of illness or problem the reader should consult a professional care provider. -
The Transhumanist Reader Is an Important, Provocative Compendium Critically Exploring the History, Philosophy, and Ethics of Transhumanism
TH “We are in the process of upgrading the human species, so we might as well do it E Classical and Contemporary with deliberation and foresight. A good first step is this book, which collects the smartest thinking available concerning the inevitable conflicts, challenges and opportunities arising as we re-invent ourselves. It’s a core text for anyone making TRA Essays on the Science, the future.” —Kevin Kelly, Senior Maverick for Wired Technology, and Philosophy “Transhumanism has moved from a fringe concern to a mainstream academic movement with real intellectual credibility. This is a great taster of some of the best N of the Human Future emerging work. In the last 10 years, transhumanism has spread not as a religion but as a creative rational endeavor.” SHU —Julian Savulescu, Uehiro Chair in Practical Ethics, University of Oxford “The Transhumanist Reader is an important, provocative compendium critically exploring the history, philosophy, and ethics of transhumanism. The contributors anticipate crucial biopolitical, ecological and planetary implications of a radically technologically enhanced population.” M —Edward Keller, Director, Center for Transformative Media, Parsons The New School for Design A “This important book contains essays by many of the top thinkers in the field of transhumanism. It’s a must-read for anyone interested in the future of humankind.” N —Sonia Arrison, Best-selling author of 100 Plus: How The Coming Age of Longevity Will Change Everything IS The rapid pace of emerging technologies is playing an increasingly important role in T overcoming fundamental human limitations. The Transhumanist Reader presents the first authoritative and comprehensive survey of the origins and current state of transhumanist Re thinking regarding technology’s impact on the future of humanity. -
Cryonics Magazine, Q1 1999
Mark Your Calendars Today! BioStasis 2000 June of the Year 2000 ave you ever considered Asilomar Conference Center Hwriting for publication? If not, let me warn you that it Northern California can be a masochistic pursuit. The simultaneous advent of the word processor and the onset of the Initial List Post-Literate Era have flooded every market with manuscripts, of Speakers: while severely diluting the aver- age quality of work. Most editors can’t keep up with the tsunami of amateurish submissions washing Eric Drexler, over their desks every day. They don’t have time to strain out the Ph.D. writers with potential, offer them personal advice, and help them to Ralph Merkle, develop their talents. The typical response is to search for familiar Ph.D. names and check cover letters for impressive credits, but shove ev- Robert Newport, ery other manuscript right back into its accompanying SASE. M.D. Despite these depressing ob- servations, please don’t give up hope! There are still venues where Watch the Alcor Phoenix as the beginning writer can go for details unfold! editorial attention and reader rec- Artwork by Tim Hubley ognition. Look to the small press — it won’t catapult you to the wealth and celebrity you wish, but it will give you a reason to practice, and it may even intro- duce you to an editor who will chat about your submissions. Where do you find this “small press?” The latest edition of Writ- ers’ Market will give you several possibilities, but let me suggest a more obvious and immediate place to start sending your work: Cryonics Magazine! 2 Cryonics • 1st Qtr, 1999 Letters to the Editor RE: “Hamburger Helpers” by Charles Platt, in his/her interest to go this route if the “Cryonics” magazine, 4th Quarter greater cost of insurance is more than offset Sincerely, 1998 by lower dues. -
Great Mambo Chicken and the Transhuman Condition
Tf Freewheel simply a tour « // o é Z oon" ‘ , c AUS Figas - 3 8 tion = ~ Conds : 8O man | S. | —§R Transhu : QO the Great Mambo Chicken and the Transhuman Condition Science Slightly Over the Edge ED REGIS A VV Addison-Wesley Publishing Company, Inc. - Reading, Massachusetts Menlo Park, California New York Don Mills, Ontario Wokingham, England Amsterdam Bonn Sydney Singapore Tokyo Madrid San Juan Paris Seoul Milan Mexico City Taipei Acknowledgmentof permissions granted to reprint previously published material appears on page 301. Manyofthe designations used by manufacturers andsellers to distinguish their products are claimed as trademarks. Where those designations appear in this book and Addison-Wesley was aware of a trademark claim, the designations have been printed in initial capital letters (e.g., Silly Putty). .Library of Congress Cataloging-in-Publication Data Regis, Edward, 1944— Great mambo chicken and the transhuman condition : science slightly over the edge / Ed Regis. p- cm. Includes bibliographical references. ISBN 0-201-09258-1 ISBN 0-201-56751-2 (pbk.) 1. Science—Miscellanea. 2. Engineering—Miscellanea. 3. Forecasting—Miscellanea. I. Title. Q173.R44 1990 500—dc20 90-382 CIP Copyright © 1990 by Ed Regis All rights reserved. No part ofthis publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Printed in the United States of America. Text design by Joyce C. Weston Set in 11-point Galliard by DEKR Corporation, Woburn, MA - 12345678 9-MW-9594939291 Second printing, October 1990 First paperback printing, August 1991 For William Patrick Contents The Mania.. -
The Signal Newsletter of the World Association for Infant Mental Health
Vol. 20, No. 1 | January–March 2012 THE SIGNAL Newsletter of the World Association for Infant Mental Health The father-child activation relationship: a new theory to understand the development of infant mental health By Daniel Paquette, Ph. D. exploration system that fosters the child’s the world (Paquette et al., 2009). According School of psychoeducation, knowledge acquisition and adaptation to Le Camus (2000), paternal roles can be University of Montreal to unfamiliar environments. Children grouped together under the function of regularly seek comfort through contact opening children to the outside world. The activation relationship theory is a with attachment figures when tired, Fathers act as catalysts for risk-taking, complement to the attachment theory. hungry, sick or afraid or when feeling inciting children to use initiative in According to John Bowlby (1969), insecure in the presence of novelty, and unfamiliar situations, to explore, take attachment consists of two opposing, this comfort provides them with the chances, overcome obstacles, be braver complementary behaviour systems: 1) necessary confidence to explore their in the presence of strangers, and stand up the proximity behaviour system that environment further. The Strange Situation for themselves (Paquette, 2004a, 2004b; ensures the child’s protection and 2) the Procedure (SSP) developed by Mary Paquette, Eugène, Dubeau & Gagnon, Ainsworth and colleagues (1978) has made 2009). This function of opening children it possible to assess the quality of the to the world is also mediated by language. Contents attachment relationship in children ages Studies have shown that fathers play the Paquette: The father-child activation 12-18 months by focusing more on the role of a linguistic bridge to the outside relationship: a new theory to understand the secure base than on the parent’s response world by using more complex forms of development of infant mental health ............1 to the baby’s need for stimulation in language (by referring to past events, exploratory contexts. -
PINTS for PRESS Business Park in Scottsdale, Arizona, Offers Two Types of “Cryonic Suspension” Services: Full-Body for $200,000, and APRIL 24 Head-Only for $80,000
COVER STORY THEFROZEN FIGHT FOR THE ONE SON’S MISSION TO MAKE HIS DAD WHOLE AGAIN BY TYLER HAYDEN Dr. Laurence Pilgeram didn’t believe in heaven, but HEAD he did believe in life after death. In 1990, at the age of 66, Pilgeram signed a contract with the Alcor Life Extension Foun- dation to freeze his body upon his death with the hope that, decades or centuries from now, medical science would resurrect him. Alcor, headquartered in a sand-colored PINTS FOR PRESS business park in Scottsdale, Arizona, offers two types of “cryonic suspension” services: full-body for $200,000, and APRIL 24 head-only for $80,000. It’s a bargain for Dr. Laurence Pilgeram a shot at immortality. Clients typically pay by signing over their life insurance policies. The head-only option, the company This article’s author, Tyler Hayden, will explains, is the most cost-effective way When Kurt demanded to to preserve a patient’s identity; using know why his father’s whole body COURTESY discuss the reporting and writing of this story future nanotechnology, a new hadn’t been preserved, he received conflicting with editor Matt Kettmann on Wednesday, body might be grown around accounts from Alcor, according to court records. First, the the brain. But Pilgeram never company said Laurence’s body had decayed beyond saving. Then, it April 24, 5:30 p.m., at Night Lizard liked the idea of “Neurocryo- claimed he hadn’t kept up with his yearly $525 membership dues. Finally, preservation,” his family has it suggested the technicians didn’t want to wait for the permit necessary Brewing Company in the Santa Barbara said, so he chose “Whole-Body to transport a full body across state lines. -
“Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014
1 “Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014 2 “We all know we must die. But that, say the immortalists, is no longer true… Science has progressed so far that we are morally bound to seek solutions, just as we would be morally bound to prevent a real tsunami if we knew how” - Bryan Appleyard 1 “The moral argument for cryonics is that it's wrong to discontinue care of an unconscious person when they can still be rescued. This is why people who fall unconscious are taken to hospital by ambulance, why they will be maintained for weeks in intensive care if necessary, and why they will still be cared for even if they don't fully awaken after that. It is a moral imperative to care for unconscious people as long as there remains reasonable hope for recovery.” - ALCOR 2 “How many cryonicists does it take to screw in a light bulb? …None – they just sit in the dark and wait for the technology to improve” 3 - Sterling Blake 1 Appleyard 2008. Page 22-23 2 Alcor.org: ‘Frequently Asked Questions’ 2014 3 Blake 1996. Page 72 3 Introduction Biologists have known for some time that certain organisms can survive for sustained time periods in what is essentially a death"like state. The North American Wood Frog, for example, shuts down its entire body system in winter; its heart stops beating and its whole body is frozen, until summer returns; at which point it thaws and ‘comes back to life’ 4. -
N E W S L E T T
PUBLISHED BY THE CRYONICS INSTITUTE ISSUE 03 | 2020 Cryonics insights and information for members and friends of the Cryonics Institute NEWSLETTER cryonics.org • [email protected] • 1 (866) 288-2796 CI BULLETIN I am proud to be a part of this history, and happy to report the Cryonics Institute continues to expand. Most notably, we are completing the improvements on our second facility. We are currently reviewing and finalizing plans to retrofit the facility with a bulk LN2 tank and insulated supply lines for the cryostats that will be used to store patients once the existing facility reaches capacity. On the financial front, the CI Board of Directors continues to monitor investments and operations to ensure the long term solvency of our organization. Despite challenges related to the covid epidemic, operations and patient care remain out- standing and have not slipped in the least. However, there are still some poor outcome situations that result directly from patient next of kin who are hostile to cryonics. Hello Everyone, In numerous issues of this magazine as well as in articles on our web site and our other social media venues we continue I hope you are all doing well during these trying times. With to stress the critical importance of identifying, planning and Covid, world politics, and a spattering of civil unrest it can be preparing for circumstances and situations that could cause a little depressing, but cryonicists are indeed a rare breed. a person to not be suspended. Historically, the two biggest We are known for thinking outside the box and rising above factors have been when family or friends actively block a any negative consensus. -
Anti-Aging: Radical Longevity, Environmental Impacts, and Christian Theology
Article Anti-Aging: Radical Longevity, Environmental Impacts, and Christian Theology Anti-Aging: Radical Longevity, Environmental Impacts, and Christian Theology Dorothy Boorse Current biomedical research shows promise for prolonging human life spans. Responses to these possible technologies vary from extreme caution, to exuberance, to a futuristic vision of humanity transforming itself. Bioethicists express concerns about big social and individual costs. Some views are expressed in the rhetoric of a culture war similar to those over cloning, stem cell research, and euthanasia. The possible effect on the environment is unknown. The biggest effect is likely to be on an increase in individual consumption of resources by a few and greater gaps between the rich and the poor. On a number of levels, radical longevity affects our view of self, humans in community, and our role in the natural world. I propose that prolonging human primary life span substantially is not a biblical mandate and is only appropriate when placed in the context of our role as humans and current environmental Dorothy Boorse and social issues. “Our technological abilities have outpaced our moral intuition” —Scholarship applicant, Gordon College 2001. n the 1998 novel The First Immortal,1 to elongate the natural human life span so Understanding Iauthor James Halperin paints a picture that people can live 150 years or longer.3 of a future world in which people rou- aging tinely have themselves frozen cryogenically until the day when scientists have cured can- Science: Why We Age, mechanisms cer and solved degenerative disorders. They Life Expectancy and can then thaw frozen people, solving their Life Span may help us medical problems so they live extremely Life expectancy, the mean likelihood of living long, almost immortal lives. -
Funeral & Obituary Planning Booklet
Funeral & Obituary Planning Booklet FROM THE PASTOR… Cremation or Not Disposition of the bodies of deceased Catholics by means of cremation is a fairly recent development. The 1917 Code of Canon Law forbade the practice, and this prohibition continued until 1963. While making allowance for cremation (as long as it was not chosen as a sign of denial of Christian teaching) the 1963 instruction Piam et Constantem issued by the Holy Office (now the Congregation for the Doctrine of Faith) urged that “the practice of burying the bodies of the faithful is by all means to be kept.” This 1963 concession is provided for in the 1969 Ordo Exsequiarum, the Latin edition of the revised Catholic funeral ritual and was later incorporated into the 1983 Code of Canon Law in canon 1176: “The Church earnestly recommends that the pious custom of burying the bodies of the dead be observed; it does not, however, forbid cremation unless it has been chosen for reasons which are contrary to Christian teaching.” The Order of Christian Funerals reflects a theology and a tradition in which burial of the body has been the principal manner of final disposition of the body. The long-standing practice of burying the body of the deceased in a grave or tomb as Jesus, continues to be encouraged as a sign of Christian faith. However, owing to contemporary cultural interaction, the practice of cremation has become part of Catholic practice in the United States and other parts of the western world. Although cremation is now permitted it does not enjoy the same value as burial of the body.