Elabscience® Recombinant Human LRP10 Protein

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Elabscience® Recombinant Human LRP10 Protein

Tel:240-252-7368(USA) Fax:240-252-7376(USA) www.elabscience.com ® E-mail:[email protected] Elabscience Elabscience Biotechnology Inc. Recombinant Human LRP10 Protein (Fc Tag) Catalog No. PKSH030687 Description Synonyms LRP9;MST087;MSTP087 Species Human Expression_host HEK293 Cells Sequence Met 1-Lys 440 Accession Q7Z4F1-1 Mol_Mass 73 kDa AP_Mol_Mass 80-90 kDa Tag C-Fc Properties Purity > 88 % as determined by reducing SDS-PAGE. Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method. Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. Shipping This product is provided as lyophilized powder which is shipped with ice packs. Formulation Lyophilized from sterile PBS, pH 7.4 Reconstitution Please refer to the printed manual for detailed information. Background Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN), plasma membrane (PM), and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing, suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease. For Research Use Only Focus on your research Thank you for your recent purchase. If you would like to learn more about proteins,please visit www.elabscience.com. Service for life science Tel:240-252-7368(USA) Fax:240-252-7376(USA) www.elabscience.com ® E-mail:[email protected] Elabscience Elabscience Biotechnology Inc. SDS-PAGE For Research Use Only Focus on your research Thank you for your recent purchase. If you would like to learn more about proteins,please visit www.elabscience.com. Service for life science Powered by TCPDF (www.tcpdf.org).

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Cholesterol in the Pathogenesis of Alzheimer's
REVIEWS Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction A. M. Petrov*, M. R. Kasimov, A. L. Zefirov Kazan State Medical University, Normal Physiology department, Butlerova str. 49, Kazan, 420012, Russia *E-mail: [email protected] Received April 22, 2016; in final form, November 28, 2016 Copyright © 2017 Park-media, Ltd. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT In our previous review, we described brain cholesterol metabolism in control conditions and in the case of some rare neurological pathologies linked to defects in the genes which are directly involved in the syn- thesis and/or traffic of cholesterol. Here, we have analyzed disruptions in cholesterol homeostasis in widespread neurodegenerative diseases (Alzheimer’s and Parkinson’s diseases) and autism spectrum disorders. We particu- larly focused on the synaptic dysfunctions that could arise from changes in both membrane cholesterol availa- bility and oxysterol production. Notably, alterations in the brain cholesterol metabolism and neurotransmission occur in the early stages of these pathologies and the polymorphism of the genes associated with cholesterol homeostasis and synaptic communication affects the risk of onset and severity of these diseases. In addition, pharmacological and genetic manipulations of brain cholesterol homeostasis in animal models frequently have marked effects on the progression of neurodegenerative diseases. Thus, the development of Alzheimer’s, Parkin- son’s and autism spectrum disorders may be partially associated with an imbalance of cholesterol homeostasis that leads to changes in the membrane cholesterol and oxysterol levels that, in turn, modulates key steps in the synaptic transmission.
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