SMARCC2 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science SMARCC2 Rabbit pAb Catalog No.: A1967 Basic Information Background Catalog No. The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose A1967 members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Observed MW The encoded protein is part of the large ATP-dependent chromatin remodeling complex 171kDa SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been Calculated MW found for this gene. 124kDa/126kDa/132kDa Category Primary antibody Applications WB,IHC Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:200 - 1:2000 Gene ID Swiss Prot 6601 Q8TAQ2 IHC 1:50 - 1:200 Immunogen A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SMARCC2 (NP_620706.1). Synonyms SMARCC2;BAF170;CRACC2;Rsc8 Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using SMARCC2 antibody (A1967) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- embedded rat kidney using SMARCC2 embedded human prostate cancer using antibody (A1967) at dilution of 1:100 (40x SMARCC2 antibody (A1967) at dilution of lens). 1:100 (40x lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Statistical Analysis of the Genomic Distribution and Correlation of Regulatory Elements in the ENCODE Regions
Downloaded from genome.cshlp.org on October 6, 2021 - Published by Cold Spring Harbor Laboratory Press Letter Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions Zhengdong D. Zhang,1 Alberto Paccanaro,2 Yutao Fu,3 Sherman Weissman,5 Zhiping Weng,3,4 Joseph Chang,6 Michael Snyder,7 and Mark B. Gerstein1,8,9 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA; 2Department of Computer Science Royal Holloway, University of London, Egham Hill, TW20 0EX, United Kingdom; 3Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA; 4Biomedical Engineering Department, Boston University, Boston, Massachusetts 02215, USA; 5Department of Genetics, Yale University, New Haven, Connecticut 06510, USA; 6Department of Statistics, Yale University, New Haven, Connecticut 06520, USA; 7Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA; 8Program in Computational Biology and Bioinformatics Yale University, New Haven, Connecticut 06520, USA The comprehensive inventory of functional elements in 44 human genomic regions carried out by the ENCODE Project Consortium enables for the first time a global analysis of the genomic distribution of transcriptional regulatory elements. In this study we developed an intuitive and yet powerful approach to analyze the distribution of regulatory elements found in many different ChIP–chip experiments on a 10∼100-kb scale. First, we focus on the overall chromosomal distribution of regulatory elements in the ENCODE regions and show that it is highly nonuniform. We demonstrate, in fact, that regulatory elements are associated with the location of known genes. Further examination on a local, single-gene scale shows an enrichment of regulatory elements near both transcription start and end sites.
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