2017 RESEARCH ANNUAL REPORT

TABLE OF CONTENTS

SUMMARIES OF 2017 NATIONAL INSTITUTES OF HEALTH AND OTHER FEDERAL GRANTS AWARDED TO HFHS

PART I – INTERNAL MEDICINE DEPARTMENT______

ALLERGY AND IMMUNOLOGY ...... 1

CARDIOLOGY/CARDIOVASCULAR RESEARCH…………………………………………….1

ENDOCRINOLOGY AND METABOLISM ...... 2

GASTROENTEROLOGY ...... 3

HEMATOLOGY/ONCOLOGY…………………………………………………………………...4

HYPERTENSION AND VASCULAR RESEARCH……………………………………………...5

INFECTIOUS DISEASE…………………………………………………………………………..9

PULMONARY……………………………………………………………………………………10

SLEEP MEDICINE ...... 11

GENERAL INTERNAL MEDICINE…………………………………………………………….13

PART II – ALL OTHER CLINICAL DEPARTMENTS______

DERMATOLOGY ...... 14

NEUROLOGY ...... 15

NEUROSURGERY……………………………………………………………………………….23

ORTHOPAEDICS/BONE & JOINT……………………………………………………………..24

PATHOLOGY ...... 25

RADIATION ONCOLOGY ...... 26

PART III POPULATION SCIENCES______

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ...... 28

DEPARTMENT OF PUBLIC HEALTH SCIENCES ...... 33

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PUBLICATIONS

ADMINISTRATION……………………………………………………………………………..46

ANESTHESIOLOGY ...... 46

BEHAVIORAL HEALTH SERVICES/PSYCHIATRY...... 46

Neuropsychology……………………………………………………………………………...47

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ...... 47

CLINICAL QUALITY AND SAFETY…………………………………………………………..49

DERMATOLOGY ...... 49

DIAGNOSTIC RADIOLOGY…………………………………………………………………....53

EMERGENCY MEDICINE ...... 55

FAMILY MEDICINE…………………………………………………………………………….56

GLOBAL HEALTH INITIATIVE ...... 57

GRADUATE MEDICAL EDUCATION………………………………………………………...57

INTERNAL MEDICINE

Allergy and Immunology……………………………………………………………………..57

Cardiology/Cardiovascular Research…………………………………………………………58

Endocrinology and Metabolism……………………………………………………………….63

Gastroenterology………………………………………………………………………………65

Hematology-Oncology………………………………………………………………………..66

Hypertension and Vascular Research ...... 68

Infectious Diseases……………………………………………………………………………69

Nephrology……………………………………………………………………………………70

Pulmonary and Critical Care Medicine ...... 71

Rheumatology…………………………………………………………………………………72

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Sleep Medicine…………………………………………………………………………….….72

General Internal Medicine/Palliative Medicine/Hospitalist/Other……………………………73

NEUROLOGY ...... 74

NEUROSURGERY ...... 79

NURSING………………………………………………………………………………………..82

OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES………………...... 82

OPTHALMOLOGY AND EYE CARE SERVICES…………………………………………….83

ORTHOPAEDICS/BONE AND JOINT……………………………………………………...….83

OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...... 86

PATHOLOGY ...... 87

PEDIATRICS...... 89

PHARMACY…………………………………………………………………………………….89

PUBLIC HEALTH SCIENCES ...... 90

RADIATION ONCOLOGY……………………………………………………………………..95

RESEARCH ADMINISTRATION

Image Analysis Program……………………………………………………………………...98

Genetics Research…………………………………………………………………………….99

SURGERY…………………………………………………………………………………….....99

Plastic Surgery…………………………………………………………………………….…102

UROLOGY……………………………………………………………………………………...102

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ABSTRACTS

ANESTHESIOLOGY ...... 106

BEHAVIORAL HEALTH SERVICES………………………………………………………...107

Psychology/Neuropsychology……………………………………………………………….107

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ...... 107

CLINICAL QUALITY AND SAFETY………………………………………………………...108

COMMUNITY HEALTH EQUITY AND WELLNESS……………………………………….108

DERMATOLOGY………………………………………………………………………………108

DIAGNOSTIC RADIOLOGY ...... 111

EMERGENCY MEDICINE ...... 113

FAMILY MEDICINE…………………………………………………………………………..115

GLOBAL HEALTH INITIATIVE ...... 115

INTERNAL MEDICINE

Allergy and Immunology…………………………………………………………………….115

Cardiology/Cardiovascular Research………………………………………………………...115

Endocrinology and Metabolism……………………………………………………………...120

Gastroenterology……………………………………………………………………………..121

Hematology-Oncology……………………………………………………………………….123

Hypertension and Vascular Research………………………………………………………...125

Infectious Disease……………………………………………………………………………126

Nephrology…………………………………………………………………………………...126

Pulmonary and Critical Care Medicine………………………………………………………127

Rheumatology………………………………………………………………………………..129

Sleep Medicine……………………………………………………………………………….129

General Internal Medicine/Palliative Medicine/Hospitalist/Other…………………………..129

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NEUROLOGY ...... 130

NEUROSURGERY ...... 134

OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES ...... 137

Urogynecology……………………………………………………………………………….138

OPHTHALMOLOGY AND EYE CARE SERVICES ...... 139

ORTHOPAEDICS/BONE & JOINT AND ATHLETIC MEDICINE ...... 139

OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...... 140

PATHOLOGY ...... 140

PHARMACY ...... 142

PUBLIC HEALTH SCIENCES ...... 142

RADIATION ONCOLOGY ...... 147

RESEARCH ADMINISTRATION

Cytogenetics ...... 153

Image Analysis Program…………………………………………………………………….153

SURGERY ...... 154

UROLOGY ...... 157

v Summaries of 2017 National Institutes of Health and other Federal Grants Awarded to HFHS

Part I –Department of Internal Medicine

• Allergy and Immunology • Cardiology/Cardiovascular Research • Endocrinology and Metabolism • Gastroenterology • Hematology/Oncology • Hypertension and Vascular Research • Infectious Disease • Pulmonary • Sleep Medicine • General Internal Medicine

Allergy and Immunology

Principal Investigator: Edward Zoratti, M.D. ICAC 3 - Inner City Asthma Consortium Infrastructure (UM1AI114271) Subcontract

The objectives of the Inner City Asthma Consortium are to implement a long range scientific plan to reduce asthma severity and prevent asthma among inner city children and to identify the mechanisms involved in the immunopathogenesis of asthma in these populations. The specific objectives are to: 1) conduct clinical trials to evaluate the safety and efficacy of promising immune based therapies in reducing asthma severity and preventing disease onset in minority children residing in inner cities in the United States; 2) conduct research to delineate the underlying mechanisms of such therapies as an integral part of the clinical trials undertaken by the Consortium; 3) conduct clinical studies on the immunopathogenesis of asthma onset, progression and severity; and 4) develop and validate surrogate/biomarkers to measure disease stage, progression and therapeutic effect.

Principal Investigator: Edward Zoratti, M.D. Pets and the Infant Microbiome: Effect on Immune Maturation & Atopic Asthma– Project 2 (P01A1089473)

The Program Project Grant (PPG) application seeks an increased understanding of the relationships between dog or cat exposure during infancy and a lower risk of allergic asthma. We believe that this protective association is related to different patterns of microbial stimulation during immune development. Four synergistic Projects will examine our hypothesis that the presence of pets in a home results in a more diverse bacterial community composition (BCC) of the dust in the home which in turn influences the development of the gut BCC of a newborn infant living in the home. A more diverse gut BCC shifts the maturation of the infant's immune system such that later immune responses are less likely to produce IgE antibody responses and allergic asthma. Project 2 will recruit a new birth cohort of children either living with or without a dog, measure infant stool BCC, and follow the cohort with detailed studies of immune function until 18 months of age to determine the impact of dog exposure on immune maturation. The Projects are supported by five Cores which each provide essential services to all four Projects.

1 Cardiology/Cardiovascular Research

Principal Investigator: David Lanfear, M.D., Hani Sabbah, Ph.D. Plasma Metabolomics and Myocardial Energetics in Heart Failure (R01HL132154)

Heart failure (HF) remains an enormous public health problem despite advances in treatment. Disease progression and response to therapy in HF varies widely between individuals, but breakthrough technologies such as genomics and metabolomics are helping to unravel the disease heterogeneity that confounds patient management. Perturbed energy metabolism may be a key contributor to cardiac dysfunction and the development of clinical HF. Evidence from a variety of sources indicates that impaired structure and function of the energetic apparatus in the myocardium contributes to disease severity, progression, and may influence response to treatment. However, in order to advance these observations toward meaningful interventions for HF patients, several key steps are still needed: 1) confirming the importance of metabolic variation in human HF, 2) developing noninvasive markers of myocardial energetic status, and 3) identifying promising targets for intervention. Our proposed project is a series of interwoven translational investigations in humans and dogs with HF to define the association of plasma metabolite levels with disease severity, myocardial energetics, and disease progression. This project leverages substantial infrastructure already in place, a large existing genetic cohort study, available plasma samples suitable for metabolomic profiling, comprehensive translational laboratory capabilities, and a cohesive multidisciplinary research group focused on HF. Together the planned studies will address the overarching hypothesis that the peripheral metabolomic signature can indicate disease progression/treatment responsiveness in HF patients and that this is driven by altered myocardial energy metabolism. If true, then these data will help advance personalized therapy and identify novel targets for HF intervention, leading to improved outcomes for HF patients.

Principal Investigator: Dee Dee Wang, M.D. Cardiac Computed Tomography and Ultrasound Core Laboratory: NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction during Transcatheter Mitral Valve Implantation (HHSN268201700225A)

Transcatheter mitral valve replacement (TMVR) is an option to treat mitral valve failure when no surgical options exist. In as many as half of patients, TMVR can cause life-threatening blockage of the left ventricle by displacing the existing mitral valve leaflet. For these patients the only options appear to avoid TMVR or in some to cause a focused heart attack and to wait 6 weeks. The investigators have developed and tested a technique to tear the existing mitral valve leaflet and enable TMVR in patients who have no other options. The procedure is called intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (LAMPOON). Although there are no dedicated TMVR devices commercially available, there has been short-term success with implanted transcatheter aortic valve devices in the mitral position for TMVR. The purpose of this study is to perform LAMPOON and TMVR in patients who have no good options to treat their mitral valve failure, using heart valve devices designed to implant in the aortic valve position. Endocrinology and Metabolism

Principal Investigator, Arti Bhan, M.D. Epidemiology of Diabetes Interventions and Complications (U01DK094157) Subcontract

The Diabetes Control and Complications Trial (DCCT, 1983-1993) compared intensive therapy aimed at near normal glycemia versus conventional therapy with no specific glucose targets in 1441 subjects with type 1 diabetes (T1DM). In 1993, after a mean follow-up of 6.5 yrs, the study showed conclusively that intensive therapy reduced the risks of retinopathy, nephropathy, and neuropathy by 35-76%, and that hyperglycemia was a primary determinant of complications. We also described potential adverse effects of intensive therapy; assessed its effects on cardiovascular disease (CVD) risk factors, neurocognition and quality of life; and projected the lifetime health-economic impact. DCCT intensive therapy was then

2 adopted world- wide as standard-of-care for T1DM. The Epidemiology of Diabetes Interventions and its Complications (EDIC, 1994-present) is the observational follow-up study of the DCCT cohort, with 95% of those surviving actively participating. Most outcomes are evaluated annually. CVD events and deaths are carefully documented and adjudicated. EDIC has notably discovered that the early beneficial effects of intensive treatment on complications have persisted for over 10 years despite the similar HbA1c levels during EDIC in the two groups, termed metabolic memory. Remarkably, former intensive therapy also greatly reduced the risk of CVD events. DCCT/EDIC collaborators have also conducted numerous ancillary studies, with separate funding, most recently including measurement of cardiac function on cardiac MRI and measurement of biomarkers of oxidative stress and inflammation as determinants of complications. The overarching goals for the next 5 years are to follow at least 90% of the surviving cohort; to describe accurately the study-long effects of glycemia (HbA1c) and other established and putative risk factors on diabetes complications and the metabolic memory effects of prior DCCT intensive therapy; and to expand knowledge regarding T1DM and its complications by supporting collaborations for new research funding applications to maximally utilize the cohort, phenotypic data set, and collected biologic and genetic samples. The specific scientific aims are to 1) evaluate effects of risk factors, biomarkers and glycemia on risk of clinical CVD; 2) assess the long-term changes in CVD risk factors; 3) describe effects of DCCT intensive versus conventional therapy on mortality; 4) evaluate risk factors for severe retinopathy/nephropathy; 5) assess effects of diurnal glycemic variation on complications; and 6) conduct eight new research projects involving new measurements and analyses.

Principal Investigator: D. Sudhaker Rao, M.D. Pathogenesis of Atypical Femaur Fractures on Long Term Bisphosphonate Therapy (R01AR062103)

Bisphosphonates (BP) have been used successfully for over a decade to prevent and treat osteoporosis and reduce osteoporotic fractures. However, since 2005 there have been many reports of atypical femoral fractures (AFF) in patients on prolonged BP therapy. Recently, it has been found that a prodromal bone deterioration (PBD) usually appears before the development to AFF. However, many PBDs may be asymptomatic, not necessarily progress to AFF, and heal spontaneously after discontinuation of BP therapy. Therefore, the prevalence of PBD may be much higher than AFF. To date, there is no evidence to support this hypothesis. It has been reported that many patients with PBD and AFF have severely suppressed bone turnover (SSBT). However, since not all patients with PBD/AFF also have SSBT, factors other than SSBT might contribute to the development of PBD/AFF. Our preliminary study suggests that PBD/AFF may be associated with osteocyte death, bone hypermineralization, and microdamage accumulation which compromise bone mechanical properties. These facts collectively led us to formulate the hypothesis that BP treated patients who develop SSBT and consequent increase in bone age, in conjunction with previous osteocyte deficiency, are predisposed to micropetrosis, accumulation of fatigue microdamage, PBD, and eventually to stress fracture manifested as AFF. To pursue this hypothesis we propose the following specific aims: Aim 1 is to determine the prevalence of PBD and AFF in 1,000 patients with postmenopausal osteoporosis, either treated with BP for more than 2 years (500 subjects), or never BP treated (500 subjects). X-rays of the femurs will be performed to systematically screen the patients for PBD/AFF. PBD can be defined as an X- ray finding of focal cortical thickening associated with a fracture line at the lateral femoral cortex.

Suspected PBD patients, whose x-ray does not show clear fracture line at focally thickened cortex, will be evaluated further using x-ray tomosynthesis, isotope bone scan or MRI. Aim 2 will determine the contribution of osteocyte deficit to PBD/AFF and SSBT in iliac bone biopsies obtained from long term BP treated patients. Degree of bone mineralization and bone nano- mechanical properties will also be assessed on these biopsies.

Gastroenterology

Principal Investigator: Stuart Gordon, M.D. Chronic Hepatitis Cohort Study II (CHeCS-II) (U18PS005154)

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Hepatitis B (HBV) affects over 1.25 million Americans, and hepatitis C (HCV) over 3.2 million Americans. In the decades to come, more than 150,000 Americans are expected to die from these conditions unless steps are taken to increase awareness, diagnosis, and access to necessary care and treatment. Emerging interferon-free, direct-acting all-oral antiviral (DAA) treatments have changed the landscape of HCV treatment and care. These treatments appear to be safer than interferon-based treatments and provide exceptionally high rates of sustained virological response (SVR). Both HBV and HCV treatment guidelines have been updated to reflect evidence regarding initiation of new therapies; however, the evidence for those recommendations is largely based on clinical trials conducted under highly controlled conditions in restricted patient populations with limited data collection. Significant health disparities—across race, sex, age, and co-infection (with HIV or dual hepatitis)—may limit the generalizability of these populations. Data from longitudinal cohorts of “real world” hepatitis patients are needed to assess the population impact of rapidly evolving antiviral therapies, to understand the spectrum of disease and its natural history, and to evaluate the public health impact of chronic viral hepatitis.

The Chronic Hepatitis Cohort Study (CHeCS) is the first comprehensive longitudinal cohort study of chronic viral hepatitis in the US, and has served as a model platform for observational data collection in this population. Since 2010, CHeCS has reported valuable information and expanded knowledge on many facets of hepatitis disease and policy. We propose to build upon CHeCS to develop “CHeCS-II,” in order to achieve the long-term goal of applying this rich data and infrastructure resource to inform public health planning, policy decisions, and clinical management of HBV and HCV. To achieve this, we will leverage the established CHeCS infrastructure, which has: (1) a diverse, real-world, non- veteran-based US cohort of >3,000 HBV, >11000 HCV, and >500 HIV co-infected patients receiving care through four U.S. health systems; (2) an experienced multidisciplinary team; (3) an efficient system for patient identification and data collection.

We will provide scientific leadership to identify research findings and priorities by: (1) Offering seamless collaboration across study sites and with the Centers for Disease Control (Aim 1); (2) Expanding our HCV cohort to over 14,000 patients with >2 years’ follow-up; (3) Increasing follow-up of HBV patients to >5 years; (4) Collecting additional data regarding social determinants of health, including access to and uptake of care (Aim 2); (5) Applying rigorous analytical approaches to develop an in-depth understanding of health disparities and comorbidities, as well as investigating how these differences impact access to and uptake of antiviral therapy; (6) Advancing translation of this research to inform hepatitis-related policy and practice (Aim 3).

Hematology/Oncology

Principal Investigator: Frederick Valeriote, Ph.D. Merging Marine-Derived Cytotoxic Natural Products with Experimental Therapeutics (R01CA047135) Subcontract

Our long-term objective is to discover and develop leads for new anticancer agents. This research utilizes a collaboration between the Marine Bioorganic Chemistry group at U. of California Santa Cruz (UCSC) led by Prof. P. Crews and the Developmental Therapeutics Program at the Josephine Ford Cancer Center (JFCC) led by Dr. F. A. Valeriote. The hypothesis is that small molecule natural products (<2000 amu), can be identified and used, to selectively inhibit the growth of solid cancer tumors. The aims outlined below will provide a foundation to discover and explore new biomolecules that will be of broad interest while also addressing general hypotheses guiding this research. Our focus is on tumors with relative insensitivity to most of the standard anticancer drugs. Thus, the overall aim is to obtain new compounds with effective activity against solid tumors, especially pancreatic, colo-rectal, breast, prostrate, brain, ovarian, and lung cancers. The general aims for the next grant period are: 1. To mine our repository of unstudied sponges either to continue or to begin new studies on both known and new bioactive, small biomolecules. 2. To use marine-derived fungi cultured in various media as a source for new active small biomolecules.

4 3. To use and refine our sponge-inspired hypothesis as the rationale for pursuing culture of Gram- positive and Gram-negative bacteria as a source of new active small biomolecules. 4. To utilize the in vitro cytotoxicity disk diffusion assay network to identify extracts obtained from Aims 1, 2, and 3 with solid tumor selectivity for follow-up fractionation and SAR expansion in Aim 6. 5. To make use of promising analytical methodologies, especially DART MS and DANS NMR, to guide further work on marine extracts, fractions, and library pure compounds obtained from Aims 1, 2, and 3. 6. To efficiently isolate, characterize and/or dereplicate compounds by focusing on the priority hits identified in Aims 4 and 5. 7. To continue capstone studies of solid tumor selective compounds through pharmacology evaluations and therapeutic assessment.

Hypertension and Vascular Research

Principal Investigator: Oscar A. Carretero, M.D. Project 1 and Project 3 Principal Investigator: Pamela Harding, Ph.D. Project 2 Autacoids in Hypertension: Pathogenesis and End Organ Damage (2P01HL028982-35)

This PPG was started in September, 1982. The central theme is "the study of the role of vasoactive systems (autocrine, juxtacrine, paracrine and endocrine) in the regulation of renal function and blood pressure (BP) and mediation of end organ damage (EOD)". The general hypothesis to be tested is that there is a balance between systems that promote water and sodium retention, hypertension and EOD, including Angiotensin II (Ang II), prostanoids, reactive oxygen species and inflammation, and systems that antagonize these effects like Ac-SDKP, activation of the Ang II type 2 receptor (AT2), kinins, NO, PGE2/EP4, and the newly discovered cross-talk between the connecting tubule and the afferent arteriole (CTGF) which may participate in both natriuresis and renal damage. Alterations of this balance in favor of the former are responsible for retention of water and sodium and development of hypertension and EOD, while alterations of this balance in favor of the latter have therapeutic effects. We will use molecular, physiological, and pharmacological approaches' to study vasoactive systems at the subcellular, cellular, and isolated organ levels in hypertension in rats and various transgenic and gene knockout mice. We will mainly use Dahl salt-sensitive rats (Dahl SS) and Ang ll-induced hypertensive rats as models. In Project I, using Dahl SS rats, we will study whether N-acetyl-seryl- aspartyl-lysyl-proline protects against EOD by decreasing adaptive immunity. In Project II we will study whether expression of cyclooxygenase-2 and generation of PGE2 via the EP4 receptor protects against EOD in Ang ll-induced hypertension. In Project III, using Dahl SS rats, we will study whether CTGF causes glomerular damage via afferent arterole dilatation and increases in capillary glomerular pressure. In Project IV, using Dahl SS rats, we will study whether a decrease in the renal thick ascending limb AT2-signaling participates in the pathogenesis of hypertension. The Four Cores - Administrative (A), Analytical and Morphological (B), Mutant Mouse (C), and Biostatistics (D) - will support the scientific efforts of the investigators. This PPG provides integration of our efforts, collaboration, sharing of ideas and expertise, thus accelerating acquisition of knowledge on the causes of hypertension and EOD. Project 4, which is subcontracted to Case Western Reserve University in Cleveland, and the 4 Cores are not described in the abstracts below.

Principal Investigator: Oscar A. Carretero, M.D. Project 1:

In hypertension, end organ damage (EOD) is due in part to the mechanical forces exerted by high blood pressure (BP); however, other mechanisms such as inflammation, oxidative stress, the RAS, and genetic predisposition, all play key roles in its pathogenesis. In hypertension, Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a naturally occurring peptide hydrolyzed mainly by ACE, reduces cardiovascular and renal inflammation and fibrosis without lowering BP. We have evidence that Ac-SDKP mediates some of the anti-fibrotic and anti- inflammatory effects of ACE inhibition and also prevents experimental autoimmune

5 myocarditis in rats. Thus we propose to test the general hypothesis that in hypertension Ac-SDKP shifts the balance between pro- inflammatory/pro-oxidative and anti-inflammatory/anti-oxidative systems in favor of the latter by decreasing innate and adaptive immunity and thus slowing the development of EOD. Furthermore, the effects of Ac-SDKP on BP and EOD are related to the degree of participation of innate and adaptive immunity in the pathogenesis of hypertension and EOD. This hypothesis will be studied in 3 aims. Aim I: In hypertensive Dahl salt- sensitive rats (Dahl SS) and in mice with systemic lupus erythematosus and hypertension, a model of autoimmune disease, Ac-SDKP acts as an immune modulator, reducing innate and adaptive immunity and thus EOD. Some of the effects of Ac-SDKP depend on the degree of participation of innate and adaptive immunity in the pathogenesis of hypertension and EOD. Aim II: The effects of ACE inh on the pro-inflammatory transcription factor NF-KB, TH cells and Treg cells are mediated by an increase in Ac- SDKP. Aim III: The effects of Ac-SDKP are multiphasic; central to these effects are decreases in: 1) the pro- inflammatory transcription factor NF-KB, 2) differentiation and maturation of dendritic cells (DCs), 3) DC transformation of T cells in effector T cells, and 4) TH cell proliferation, activation, migration, and differentiation into pro- inflammatory phenotypes. The effects of Ac-SDKP on TH are partly due to an increase in Treg cells.Project I is related to III and IV which also study Dahl SS; 2) II and III, which also study the pathogenesis of EOD; and 3) II and IV which also study Ang II. Project 1 will use all 4 Cores.

Project 3:

In hypertension, high glomerular capillary pressure (PGC) leads to glomerulosclerosis. In African- Americans with salt-sensitive (SS) hypertension, high salt intake causes an increase in estimated PGC, which could explain their high rate of hypertensive renal disease. Dahl SS rats on high salt intake have hypertension, high PGC and significant glomerular injury compared to SHR with similar blood pressure. Connecting tubule glomerular feedback (CTGF) is a cross- talk that dilates the afferent arteriole (Af-Art) when Na is increased in the connecting tubule (CNT). General hypothesis: In SS hypertension, during high salt intake there is an imbalance between factors that cause Af- Art constriction (myogenic response and TGF) versus dilatation (CTGF) in favor of the latter, leading to an increase in PGC and glomerular damage. Aim I, Hypothesis: In normotensive animals, chronic high salt intake causes TGF resetting due to heightened CTGF via increased release of EETs and PGE2 by the CNT. Mice with a gain-of-function mutation of ENaC have increased CTGF and reduced TGF, while mice with deletion of ENaC in the CNT have decreased or no CTGF and enhanced TGF. Aim II, hypothesis: In hypertensive Dahl SS rats CTGF is increased, causing TGF resetting leading to increases in PGC and glomerular damage. Conversely, in SHR CTGF is decreased, causing an enhancement of myogenic response and TGF which in turn decreases PGC and protects the glomerulus from damage. In SHR, high salt will increase CTGF, causing attenuation of the myogenic response, TGF resetting, increased PGC, and glomerular damage. In Ang II-induced hypertension in mice with increased ENaC activity, glomerular damage will be greater due to an increase in CTGF, while in mice with selectively decreased ENaC in the CNT glomerular damage will be lower, due to a decrease in CTGF. Aim III, hypothesis: In hypertensive Dahl SS rats, CTGF is augmented due to increases in ENaC, COX-2 and PGE2. In contrast, in SHR CTGF is attenuated due to increased soluble epoxide hydrolase and decreased EET release. Project III is closely related to 1): I and IV which also study Dahl SS; I and II which also study the pathogenesis of EOD; and II which also studies arachidonic acid metabolites. Project III will use all 4 Cores.

Principal Investigator: Pamela Harding, Ph.D. Project 2:

Uncontrolled hypertension (HTN) is a major cause of end organ damage (EOD) and a risk factor for cardiovascular morbidity and mortality. Although prostaglandin E2 (PGE2) was historically thought to be a mediator of inflammation, more recent evidence suggests that it may be pro or anti- inflammatory, depending on the involvement of specific PGE2 EP receptor sub-types that signal through divergent signaling pathways. We previously reported that aged male mice lacking the EP4 receptor on cardiomyocytes develop heart failure characterized by reduced ejection fraction, left

6 ventricle dilation and fibrosis, coupled with elevated expression of chemokines (fractalkine and MCP- 5) in the left ventricle. This proposal examines whether the protective and anti-inflammatory effects of PGE2 via EP4 are mediated by reduced fractalkine and MCP-5. It tests the general hypothesis that EP4, activated by PGE2, reduces the EOD that occurs in Angiotensin II (Ang II)-dependent hypertension and myocardial infarction (MI) by inhibiting the production and/or release of the inflammatory chemokines fractalkine and MCP-5. Aim I will study whether PGE2 via its EP4 receptor reduces production and /or secretion of fractalkine and MCP-5 via its EP4 receptor and cAMP in cardiac myocytes and fibroblasts and opposes the deleterious effects of Ang II. AIM II will study whether EP4- dependent reductions in fractalkine and/or MCP-5 improve cardiac function both in vivo and in vitro. Aim III will study whether PGE2 via its EP4 receptor and inhibition of fractalkine and/or MCP-5 synthesis and/or release prevents EOD by reducing infiltration of inflammatory cells into the myocardium in models of Ang II-dependent HTN and myocardial infarction (MI). The proposal will utilize a novel mouse model coupled with state-of-the art molecular techniques to address these aims. These studies are of utmost importance in determining the role of PGE2 and EP4 in cardiac hypertrophy and EOD. Project II is closely related to: 1) Projects I and III which also study the pathogenesis of EOD; 2) Project IV which also studies AT1 receptors and superoxide; and 3) Project III which also studies arachidonic acid metabolites. Project II will use all 4 Cores.

Principal Investigator: Mariela Mendez, Ph.D. Hydrogen Peroxide Stimulates Renin Release: Role in Hypertension and Diabetes (R03DK105300)

Hypertension and diabetes are the principal cause for chronic kidney disease (CKD). In both diseases, a high percentage of patients show activation of the renin angiotensin system (RAS). Renin is the rate-limiting enzyme in the activation of the RAS. Thus, understanding the mechanism and proteins involved in the release of renin may offer alternative targets for hypertension and CKD. Renin is stored in dense-core granules in juxtaglomerular (JG) cells, located at the pole of the renal afferent arteriole, in the kidney cortex. In hypertension and diabetes, reactive oxygen species, including hydrogen peroxide (H2O2), are enhanced in the kidney cortex. We found that hydrogen peroxide stimulate renin release from JG cells. However, the enzymes responsible for production of hydrogen peroxide in JG cells have not been identified. Hydrogen peroxide is mainly a product of superoxide dismutation or enzymatic formation by NADPH oxidases (NOX1-5). The NOX4 isoform preferentially produces hydrogen peroxide and its expression in the renal cortex is enhanced in diabetes and hypertension. Our preliminary data shows that NOX4 is expressed in renin granules in JG cells, suggestive of intragranular production of H2O2. However it is not known whether NOX4 produces the pool of hydrogen peroxide that stimulates renin release from JG cells; and whether NOX4/H2O2-induced renin release contributes to increase blood pressure and kidney damage in diabetic nephropathy. In addition the mechanism by which H2O2 stimulate renin release is unknown. In other cells H2O2 induces signaling by oxidation of protein thiols. In this proposal we will test the hypothesis that the NADPH oxidase isoform NOX4 produces hydrogen peroxide in juxtaglomerular cells and stimulate renin release, thereby increasing blood pressure and contributing to glomerular damage. We will also explore the protein targets by which H2O2 stimulates renin release. In Aim 1 we will use primary cultures of juxtaglomerular cells, isolated afferent arterioles and Akita mice to test the role of NOX4-derived hydrogen peroxide in renin release in vitro and in vivo. In Aim 2 we will use a proteomics approach and subcellular fractionation of renin granules, to identify proteins that are oxidized by hydrogen peroxide in juxtaglomerular cells. This approach will allow us to collect critical preliminary data for an RO1 submission and focus on new protein targets of hydrogen peroxide that mediate renin release.

Principal Investigator: Pablo Ortiz, M.D., Ph.D. Fructose Induced Salt-Sensitive Hypertension: Role of Thick Ascending Limb Transport (R01DK107263)

A high-fructose diet is linked to the epidemic of hypertension, diabetes, and obesity. Up to 25 million

7 Americans consume up to 20% of their calories from added fructose1,2. We found that feeding rats a fructose-enriched diet (20%) for 4 weeks did not increase blood pressure. However, a fructose-enriched diet combined with high salt (4% Na) caused salt-sensitive hypertension within 1 week (Figures 1,11); prior to the development of metabolic abnormalities. The initial phase of salt-sensitive hypertension is in part mediated by a renal defect that prevents NaCl excretion during high salt intake. The thick ascending limb (TAL) reabsorbs 25% of filtered NaCl. Enhanced TAL NaCl absorption is related to salt-sensitive hypertension in humans and rodents3-5. However, the mechanism by which a fructose-enriched diet rapidly (1 week) causes salt-sensitive hypertension is not clear and the role of TAL NaCl absorption in this process is completely unknown.

NaCl reabsorption by the TAL depends on the apical Na/K/2Cl cotransporter NKCC2, the target of loop diuretics. Our preliminary data show that a fructose-enriched diet enhanced NKCC2 phosphorylation at Threonine (Thr)96,101. NKCC2 phosphorylation at Thr96,101 activates NKCC26,7. Our data show that NKCC2-mediated NaCl transport is abnormally elevated in rats fed fructose plus a high salt diet. However, the effects of fructose and the signaling induced in the TAL and the distal nephron have not been studied. Our data show that plasma and urine fructose increase rapidly after fructose intake. Thus, fructose reaching the nephron may be transported in by a fructose channel, activating protein kinase signaling. The only kinases known to phosphorylate Thr96,101 of NKCC2 are SPAK (STE20/SPS1- related proline-alanine-rich kinase) and OSR1 (Oxidative Stress Responsive 1) kinases. In the TAL, these kinases specifically phosphorylate NKCC2. In the distal convoluted tubule (DCT), these kinases specifically phosphorylate the thiazide-sensitive NaCl transporter NCC. We found that a 20% fructose diet increases SPAK/OSR1 phosphorylation in TALs. In addition, stimulation of β-adrenergic receptors (β-AR) in the TAL activates NKCC213. A fructose-enriched diet may increase sympathetic activity by 2 weeks12, or enhance the sensitivity or signaling of β-AR. Our preliminary data show that β- AR stimulation increases SPAK/OSR1 phosphorylation in TALs. In the Dahl salt sensitive (SS) rat, NKCC2 and SPAK/OSR1 phosphorylation are abnormally enhanced in a normal salt diet. It is not known whether this increases the effect of fructose on blood pressure and NaCl absorption. We hypothesize that a fructose-enriched diet enhances thick ascending limb (TAL) and distal tubule (DCT) NaCl absorption by inducing NKCC2 and NCC phosphorylation via SPAK/OSR1 kinases and enhanced β-AR signaling. These effects occur within 1 week, prior to metabolic alterations, and are maintained chronically (16 weeks), promoting salt- sensitive hypertension in normal rats. In Dahl SS rats, abnormally elevated SPAK/OSR1 in the TAL, enhances the effect of fructose on blood pressure in normal- or high-salt diets.

Principal Investigator: Suresh Palaniyandi, Ph.D. 4-hydoxy-2-nonenal in Mitochondrial DNA Damage and Contractile Dysfunction in Diabetic Heart: A Role for Aldehyde Dehydrogenase 2 (R56HL131891)

Diabetes mellitus (DM) afflicts 26 million people in the US. 40-70% of these diabetics die of cardiovascular complications. We and others found that DM increases reactive oxygen species (ROS)- mediated aldehydes like 4-hydroxy-2-nonenal (4HNE) generation. 4HNE forms covalent bonds with macromolecules known as adducts, which lead to cellular damage and decreased cardiac function. Aldehyde dehydrogenase (ALDH2) is a mitochondrial enzyme that detoxifies 4HNE in the heart. We and others reported that in streptozotocin-induced hyperglycemic models, ALDH2 levels and activity in the heart are reduced, whereas 4HNE protein adducts are increased. Although we think this causes cardiac dysfunction, the exact mechanism is unclear. However, most diabetic patients have type-2 DM. Thus, it is imperative to investigate whether hyperglycemia-induced 4HNE and lower ALDH2 activity contribute to cardiac dysfunction in type-2 DM models. We recently demonstrated that high glucose stress or 4HNE administration decreased mitochondrial respiration with increased mitochondrial DNA (mtDNA) damage in cultured cardiomyocytes. In our preliminary study using type-2 diabetic mouse heart, we found an increase in mitochondrial levels of 8-hydroxyguanine (8OHG), an oxidized mtDNA product. 8- oxoguanine glycosylase (OGG)-1 is responsible for identification and excision of 8OHG. Next, we found increased 4HNE adduct formation on OGG-1 and reduced OGG-1 levels. These data suggest that 4HNE adduction on OGG-1 reduces its level and activity thereby raising the unmetabolized 8OHG level. Thus we postulate that 4HNE-mediated mtDNA damage is part of the mechanism by which lower

8 ALDH2 activity causes mitochondrial respiratory dysfunction. To test our idea, we will use a high-fat diet induced type-2 DM model in wild type (WT) C57BL/6 and ALDH2*2 mutant mice. This mutation mimics East Asians with the E487K variant (ALDH2*2), which exhibits lower ALDH2 activity. We will treat our diabetic mice with Alda-1, the only specific drug available to improve the catalytic activity of both WT and mutant ALDH2. We propose following three specific aims: Aim 1-Hyperglycemia in models of type-2 diabetes reduces ALDH2 activity in the heart by increasing 4HNE adduction with ALDH2, further leading to cardiac dysfunction: Aim 2-Reduced ALDH2 activity leads to increased 4HNE adduct formation on mtDNA and 8-oxoguanine glycosylase (OGG)-1, a mtDNA repair enzyme, thereby causing mtDNA damage and poor mitochondrial respiration in type-2 DM: AIM 3-Augmenting ALDH2 activity ameliorates cardiac function in type2-DM. This study will identify a novel role of ALDH2 in hyperglycemia mediated cardiac dysfunction and establish that ALDH2 could be a therapeutic target for restoring cardiac function in DM patients.

Principal Investigator: Tengis Pavlov, Ph.D. Regulation of ENaC in Salt-Sensitive Hypertension via Inflammation-Induced ROS Production (R00HL116603)

Reduced ability to maintain sodium homeostasis and normal levels of arterial pressure is the hallmark of salt-sensitive hypertension (SSH). In the kidney, discretionary Na+ reabsorption mediated by epithelium sodium channel (ENaC) is a determinant of the pressure-natriuresis relationship which is of fundamental importance in the long-term control of arterial pressure. According to the initial proposal we continue developing specific aims focused on regulation of ENaC by reactive oxygen species (ROS) in this pathological condition. Our data indicate that ENaC-mediated Na+ reabsorption in the distal nephron contributes to salt-sensitive hypertension in and I hypothesize here that excessive H2O2 production mediates this effect. Using genetically modified strains derived from Dahl Salt-Sensitive rats, we found that ROS production by renal tissue NADPH oxidase significantly contributes to upregulation of ENaC activity associated with high salt consumption. As planned initially, the current proposal is focused on Aim 2 studying cellular and molecular mechanisms by which ROS modulate ENaC activity and complete Aim 1. We hypothesize here that H2O2 production increased in response to high salt diet results in destroying of the actin cytoskeleton and activation of ENaC activity. Moreover, we propose that cortactin and MIM proteins are required for proper regulation of the channel by the actin cytoskeleton. Also, we shall continue studies on the role of different NADPH oxidase subunits and T-cell infiltration in the development of hypertension in Dahl SS rats. This work provides mechanistic insight on the relationships between high salt consumption, development of high blood pressure, inflammation and kidney damage and the role of sodium reabsorption. Such approach allows generating clinically relevant data interesting for broad scientific community.

Infectious Disease

Principal Investigator: Marcus Zervos, M.D.

A Phase 2 Randomised, Double-blind, Placebo-controlled, Single-dose, Dose-ranging Study of the Efficacy and Safety of MEDI4893, a Human Monoclonal Antibody Against Staphylococcus aureus Alpha Toxin in Mechanically Ventilated Adult Subjects (UM1AI104681) Subcontract A Phase 2 Proof-of-concept Study to Evaluate the Efficacy and Safety of MEDI3902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginosa (UM1AI104681) Subcontract

Our goal is to create and implement an Antibacterial Resistance Leadership Group (ARLG) that will develop, design, implement, and manage a clinical research agenda that will increase knowledge of and mitigate the important factors that drive resistance. We will pair an unprecedented team of over two dozen of the world's top investigators with the organizational excellence of the Duke Clinical Research Institute (DCRI), one of the world's largest Academic Research Organizations. Because of the complexity of integrating multiple components of such a large-scale clinical research network, our submission features centralized leadership through an Executive Committee and a dual PI approach.

9 One PI (Fowler) focuses primarily on operations and the other (Chambers) focuses largely on scientific agenda. The organizational structure, modeled after that of the ACTG, also features Scientific Subcommittees devoted to four priority areas: Gram-negative bacterial infections, Stewardship and infection prevention, Gram-positive bacterial infections, and Diagnostics and devices. These Subcommittees are supported by three Special Emphasis Panels (SEPs) (Pediatrics, Pharmacokinetics, and Special Populations) and a Mentoring Core. Each Subcommittee, SEP, and Core contains internationally recognized investigators, ensuring expertise. To complement the current research activities of both NIH and the pharmaceutical biotechnology industry, our ARLG has established collaborative ties with members of both communities. Our long-term goals are 1) to complete a superiority trial of new anti-infectives (either new agent or new dosing regimen of existing agent) for MDR-Gram negative bacterial infections; 2) to define shorter course, narrow-spectrum therapeutic regimens for common infections as a principal means to support stewardship; 3) to test a rapid diagnostic that identifies antimicrobial resistance based on genotypic markers in bacteria; and 4) to identify a more effective alternative to vancomycin for MRSA infections. The research agenda reflects our overall strategy of making realistic, incremental steps in early phase studies upon which to build toward more complex transformational trials that will change clinical practice and reduce the impact of antibacterial resistance.

Pulmonary

Principal Investigator: Bruno DiGiovine, M.D. CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL Network: VIOLET: Vitamin D to Improve Outcomes by Leveraging Early Treatment (U01HL123009) Subcontract

This proposal is a response to the RFA-HL-14-015 for the coordinating center of the Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network. We propose to provide leadership in the design, analysis and conduct of the studies of the PETAL Network and to provide the infrastructure and communications that will create a cohesive and productive group. Over the past 18 years we have served as the coordinating center of the Acute Respiratory Distress Syndrome (ARDS) Network under the leadership of an experienced clinical trials statistician and an acute care physician. We recently published our approach to the statistical and logistics issues of the ARDS Network. We propose to enhance those methods to improve performance of these activities for PETAL. Our proposal for the PETAL network focuses on the novel challenges of prevention trials. We suggest that the feasibility of a prevention trial depends on the choice of endpoint, in particular that studies using mortality as the primary endpoint would not be feasible with a conventional trial design and other clinical endpoints may be problematic. The optimal endpoint would be the occurrence of ARDS or a measure of the clinical consequences of ARDS. The proposal discusses the issues of cluster randomized trials and adaptive designs. We discuss the statistical and scientific issues in creating a biomarker resource for the PETAL Network. We also describe our proposals to increase productivity of the network by implementing an efficient IRB review process, plans for applying a computer-assisted technique to set network priorities, and plans for soliciting community involvement on an ongoing basis. We describe the methods we will use to provide the needed infrastructure (such as a remote data and trial management system) and the coordination of all network activities: data quality control, protocol compliance, protocol initiation, randomization, drug distribution, sample management, adverse event reporting, statistical reporting, data dissemination, communication, and logistics.

Principal Investigator: Bruno DiGiovine, M.D. Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung: Reevaluation of Systemic Early Neuromuscular Blockade (U01HL123031) Subcontract

Purpose: This study is evaluating whether giving a neuromuscular blocker (skeletal muscle relaxant) to a patient with acute respiratory distress syndrome will improve survival. Half of the patients will receive a neuromuscular blocker for two days and in the other half the use of neuromuscular blockers will be discouraged .

10 Trial Summary: Study Design: This is a multi-center, prospective, 2-arm, unblinded, randomized clinical trial of two management strategies of neuromuscular blockade (also called skeletal muscle relaxant and muscle relaxant). Purpose: To assess the efficacy and safety of early neuromuscular blockade in reducing mortality and morbidity in patients with moderate-severe ARDS in comparison to a control group with no routine early neuromuscular blockade. Sample Size: This trial will enroll approximately 1400 subjects from PETAL network hospital ICUs.

Principal Investigator: Jennifer Swiderek, M.D. Testing a Nurse-led Algorithmic Approach to Terminal Ventilator Withdrawal (R01NR015768) Subcontract

Terminal ventilator withdrawal is a process that entails the cessation of mechanical ventilatory support with patients who are unable to sustain spontaneous breathing and is commonly performed in the ICU. Ventilator withdrawal is undertaken to allow a natural death. Opioids and/or benzodiazepines are administered before, during, and after as an integral component of the ventilator withdrawal process to prevent or relieve respiratory distress, but there are few guidelines to determine how much to administer or when. Insufficient opioid and/or benzodiazepine administration places the patient at risk for unrelieved respiratory distress and preventable suffering. Conversely, excessive medication administration may hasten death, an unintended consequence, and one that concerns clinicians. The effective doses of medications given during ventilator withdrawal are unknown. We hypothesize that an algorithmic approach to ventilator withdrawal, relying on a biobehavioral instrument to measure and trend distress, will ensure patient comfort, and guide effective opioid and/or benzodiazepine administration. We plan to use a stepped wedge cluster randomized controlled trial with all clusters providing unstructured usual care until each cluster is randomized to implement the algorithmic approach (intervention). The proposed study is innovative because there is no standardized, evidence- based approach guided by an objective measure of respiratory distress to this common ICU procedure. The study has broad clinical significance to provide knowledge that can potentially reduce patient suffering.

Sleep Medicine

Principal Investigator: Philip Cheng, Ph.D. Clinical Translation of Phenotypes of Shift Work Disorder (1K23HL138166)

Shift work disorder (SWD) is a significant threat to public health and safety; over 6 million shift workers in the United States experience the debilitating symptoms of excessive sleepiness and insomnia, and suffer functional impairments that increases the risk of catastrophic industrial accidents. However, patients with SWD are often inadequately treated because the pathophysiology is not well- characterized, and current diagnostic assessments do not identify specific treatment targets. Consequently, clinicians are unable to deliver precise interventions that target the underlying causes of SWD. The proposed project in this career development award will address these gaps by taking the initial steps of translating two phenotypes of SWD for clinical use. Previous research has indicated that SWD can arise from two independent pathways that can be categorized as pathophysiological phenotypes. The first is the circadian misalignment phenotype, characterized by poor adjustment of the biological clock to the nocturnal work schedule. The second is the sleep reactivity phenotype, characterized by a trait vulnerability to sleep disturbance triggered by environmental stressors. Both phenotypes lead to symptoms of sleepiness and insomnia in SWD, and is not currently distinguished in the clinic; however, the requisite treatments for each pathophysiological phenotype are entirely different. As such, the appropriate intervention of SWD requires that these phenotypes be adequately characterized and identified in the clinic. The proposed aims will complete the requisite foundational research to launch the translation of these phenotypes of SWD for clinical use. The first research aim will examine the stability of each phenotype in shift workers to characterize them as either state or trait phenotypes, which will impact both assessments of interventions. The second research aim will identify the specific clinical attributes that can be used to index the phenotypes in a brief, accurate, and cost- effective assessment tool. Finally, the third research aim will identify differences in cognitive and

11 performance deficits between the two phenotypes so that accidents and injuries can be preempted with targeted interventions. To successfully complete the research aims, and to support my long term goal of conducting translational research to improve the health and productivity of shift workers, this career development award will provide further training in the following areas: (1) development of clinical screening tools, (2) advanced methodologies in clinical and translation research, (3) feasibility of real- world behavioral interventions for shift work disorder, and (4) advanced field measurement of circadian phase. In combination, the training activities outlined in this career development award will provide the necessary expertise for a sustained career in translational research and circadian medicine.

Principal Investigator: Christopher Drake, Ph.D. Behavioral Treatment of Menopausal Insomnia; Sleep, Depression, Daytime Outcomes (R01NR013959)

Insomnia is recognized as one of the most prevalent and costly sleep disorders and is associated with considerable morbidity including significantly reduced quality of life, impaired work performance, and increased risk for major depressive disorder. Insomnia is a key symptom of the menopausal transition with 40-50% of postmenopausal women (> 17 million) having insomnia. Insomnia associated with menopause has a pattern of sleep disturbance predominantly characterized by sleep maintenance difficulties including frequent awakenings and arousals, reduced sleep efficiency, and overall fragmented sleep. It has recently been demonstrated that this pattern of sleep disturbance, difficulty maintaining sleep, increases throughout the progression of menopause. We have recently found sleep maintenance problems in menopause are associated with reduced work performance, increased healthcare utilization, and impaired quality of life. Historically, menopausal symptoms including sleep disturbance, were treated using hormone replacement therapy (HRT). However, evidence linking HRT to increased risks of heart disease and cancer have led to a 40% reduction in the use of sex steroid hormones by postmenopausal women and highlight the need for alternative approaches to treatment. Importantly, the American Association of Clinical Endocrinologists guidelines for management of menopause do not address treatment of menopausal-related insomnia due to the absence of research findings in this area. Cognitive-behavioral therapy for insomnia (CBT-I) yields equivalent short-term efficacy and superior long-term durability to pharmacological treatment of insomnia. However, the efficacy of cognitive behavioral therapy for insomnia comorbid with menopause, one of the primary focuses of the present proposal, has not been tested. Traditional CBT-I has disadvantages however, including the need for a trained therapist and significant time commitment on the part of the patient. Therefore, widespread availability of multicomponent CBT-I is limited by the relatively low number of CBT sleep specialists, complexity of therapy, and patient burden. Thus, another aim of this project is to test the acute and long-term efficacy of a single component behavioral therapy for menopausal- related insomnia. Given the significant daytime impairment present in insomnia comorbid with menopause including depression, quality of life, and fatigue, a final aim of this proposal is to determine the efficacy of CBT-I on these measures in women with menopausal- related insomnia.

The project will test the efficacy of cognitive-behavioral therapy for insomnia (CBT-I), as a safe and effective evidence-based alternative to medication for sleep disturbance associated with menopause. Because CBT-I is costly and time intensive, we will also test the efficacy of abbreviated single component sleep restriction therapy (SRT) in the treatment of menopausal- insomnia. Importantly, we will also test the efficacy of each of these treatments on improvements in depression, fatigue, and quality of life.

Principal Investigator: Timothy Roehrs, Ph.D. Risks for Transition from Therapeutic Hypnotic Use to Abuse (R01DA038177)

The acknowledged drugs of choice for the pharmacological treatment of insomnia are the benzodiazepine receptor ligand hypnotics (BzRL). Our nighttime studies show that with therapeutic doses used either short-term or chronically, the abuse liability of BzRLs in insomnia is not seen

12 universally and is relatively low. The data from our last grant, a first-ever study, showed the abuse liability of chronic zolpidem use in insomniacs was low. Yet case reports and retrospective studies continue to report BzRL dependence and for the majority of these cases the abuse developed through initial therapeutic use. In our study some subjects showed an increase in dose across time. Understanding the transition from therapeutic use to abuse and identifying risk factors, such as specific patient and drug characteristics, is both mechanistically and clinically important. Our preliminary data have shown that a subset of insomniacs, those insomniacs that have signs of hyperarousal as reflected by elevated Multiple Sleep Latency Test (MSLT) scores, increased their nightly zolpidem dose across time. BzRLs have differential receptor binding affinities and associated anxiolytic or antidepressant properties. Zolpidem has selective alpha 1 BzRL affinity and little mood activity and thus may show less risk for transition from therapeutic use to abuse than another currently frequently prescribed BzRL with less alpha subtype selectivity such as eszopiclone. We propose to study the abuse liability of a selective (zolpidem) vs nonselective (eszopiclone) hypnotic during chronic use (six months) in an at-risk sub-population (insomniacs with hyperarousal shown by elevated MSLTs). The proposal is highly innovative as it reflects a paradigm shift in understanding the abuse liability of hypnotics. In the end, this proposal will generate a unique set of data addressing a number of previously clinically important unanswered questions regarding hypnotic abuse by insomniacs (i.e., its likelihood as a function of arousal state and specific hypnotic pharmacology, of dose escalation over time and change in mood/drug effect ratings over time). It will provide clinicians with behavioral indicators of abuse risk.

General Internal Medicine

Principal Investigator: Michelle Schreiber, M.D. eASSIST A Post-Visit Patient Portal Tool to Promote Colorectal Cancer Screening (R01CA197205) Subcontract

Colorectal rectal cancer (CRC) is the third most common cancer in the US with over 50,000 individuals dying annually from the disease. Despite multiple effective screening tests, CRC screening remains underutilized relative to other cancer screening. A driving factor behind this underutilization among insured populations is the gap that exists between a physician recommendation for care and the patient's receipt of screening. How best to support patients in CRC screening once they have a physician recommendation for care remains unknown. The proposed project will test the effectiveness and impact of a post-visit, patient portal tool, e-Assist, for engaging and supporting primary care patients in their decision making regarding, and ultimately in their obtaining, CRC screening. The tool purposely leverages the cue to action provided by a physician recommendation for care as well as the secure patient portal platform now commonly found within primary care practices. It seamlessly combines important patient-physician decision making content with assistance in removing personal and structural barriers to screening. Our research will answer four overarching questions: (1) Can a post-visit, patient portal tool, e-Assist, increase adherence to physician-recommended CRC screening? (2) How does e- Assist engage primary care patients in the CRC screening decision making process? (3) Are there subgroups of the primary care population for whom e-Assist is more engaging and effective? and (4) What adaptations are needed to e-Assist to improve its reach, and ensure its adoption, implementation, and ultimately its impact on evidence-based CRC screening use among diverse primary care patients and clinics? These questions will be addressed using a two-arm, practical randomized trial supplemented with findings from focus groups and in-depth interviews with patients, clinicians and other clinic staff to ensure a comprehensive understanding of not only program effectiveness and implementation, but the factors driving overall program impact. Results will illustrate how e-tools can be used following an office visit to support both patient decision making, and the dissemination and implementation of evidence-based cancer screening services in primary care.

13 Part II – All Other Clinical Departments

• Dermatology • Neurology • Neurosurgery • Orthopaedics/Bone & Joint • Pathology • Radiation Oncology

Dermatology

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. microRNAs and NKT Cell Development and Function (R01AI119041)

Natural killer T (NKT) cells are an evolutionarily conserved subset of T cells that are developmentally and functionally distinct from conventional T cells. The ability to quickly secrete large quantities of a variety of cytokines upon activation enables NKT cells to be potent regulators of diverse immune responses. The deficiencies in NKT cell number and function have been linked to the development of many diseases. However, a significant gap remains in our understanding of how the development and function of NKT cells are precisely regulated. MicroRNAs (miRNAs), a recently discovered class of evolutionarily conserved small non- coding RNAs, negatively regulate the expression of protein-coding genes and thereby control essential biological functions and contribute to the development of many diseases. We were the first to report that the deletion of Dicer (a key enzyme for miRNA biogenesis) during hematopoiesis results in a significantly reduced NKT cell number and impaired NKT cell maturation and function, without alternating conventional T cell development in the thymus, suggesting that miRNAs are required for NKT cells. Our long-term goal is to understand how miRNAs regulate NKT cell development and function. While more than 1000 experimentally reported miRNAs, very few specific miRNAs are linked to NKT cells so far. Our objective here is to define specific miRNAs and their targets that regulate NKT cell development and function. Using miRNA arrays, we recently identified dynamic expression of miRNAs, including miR- 155, and miR-17-92 cluster, during NKT cell development and activation. These findings plus our recent other report lead to our central hypothesis that these dynamically expressed miRNAs serve as critical regulators controlling NKT cell development and function through fine-tuning of specific target genes. Here we will further test this hypothesis. We will investigate how dynamic and miR-155 and miR-17-92 expression regulates NKT cell development and function using specific miRNA mutant mice with the gain or loss of miRNA gene. The results from proposed studies may not only illuminate the new immunological and molecular mechanisms underlying NKT cell development, but may also facilitate the development of new and more efficient intervention strategies for autoimmune diseases, infection, and cancer based on the NKT cell therapy.

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. Roles of HDAC3 in Epidermal Langerhans Cell Ontogeny and Function (R01AR069681)

Langerhans cells (LCs), the skin residing dendritic cells (DCs), form a contiguous immune network in skin and are involved in allergy, infection, cancer, and autoimmune disease development. However, the regulatory mechanisms involved in the development and functions of LCs have not been completely elucidated. Histone deacetylases (HDACs) are enzymes that regulate gene expression by modifying chromatin structure through removal of acetyl groups from target histones or directly deacetylating nonhistone proteins, and represent a key epigenetic regulatory mechanism. HDAC inhibitors (HDI) are shown to have anti-tumor and anti- inflammatory effects in a variety of diseases, in which LCs play an important role. However, the mechanisms underlying the clinical effectiveness of HDI remain largely unknown. We recently reported that the inhibition of Class I/II HDACs by Trichostatin A (TSA) regulates the homeostasis and function of LCs in vitro and in vivo and modulates the non-coding miRNA expressions in LCs, while miRNAs also control LC development and function.

14 Our preliminary data indicate that LCs express all Class I/II HDACs. To evaluate the role of individual HDACs in LC development and function, we generated knockout (KO) mice with selective deletion of HDAC3 (Class I) or HDAC4 (Class II) in epidermal LCs. Interestingly, LC number was significantly reduced in LC-HDAC3KO mice, but unaffected in LC-HDAC4KO mice. Furthermore, LC maturation and function were altered in LC-HDAC3KO mice. Thus, we hypothesize that HDAC3 is a key epigenetic component that controls LC development and function. In Aim 1, we will investigate the roles of HDAC3 in LC development and homeostasis, using LC-HDAC3KO mice for homeostasis after birth and using constitutive Csf1r-specific HDAC3-deletion mice (Csf1r-HDAC3) and inducible Csf1rspecific HDAC3-deletion (Csfr1.Mer-HDAC3) mice for early embryonic LC development; Aim 2, we will investigate the roles of HDAC3 in LC function, using inducible LCER. HDAC3KO mice. In Aim 3, we will elucidate the molecular mechanisms and signaling pathways by which HDAC3 regulates LC development and function, by combining cDNA array, miRNA array and ChiP-Seq techniques. The proposed studies will uncover the epigenetic regulatory mechanisms of HDAC3 in LC development and function, and may also elucidate new mechanisms for HDI therapy.

Principal Investigator: Qing-Sheng Mi, M.D., Ph.D. Serum MicroRNA Biomarkers of Islet Autoimmunity (R01AI123258) Subcontract

Under Dr. Mi’s leadership, the team at Henry Ford Health System will perform miRseq profiles and quantitative miRNA analysis on serum samples using the Exiqon RT-PCR platform. Based on preliminary data, a custom panel of 188 microRNAs will be used. This strategy will allow greatly reducing the cost of measuring microRNAs by almost 50% and yet allow to study serum microRNA extensively; making it possible to measure a larger number of samples for increased statistical power. Over the course of the four year program, we anticipate measuring microRNA levels in 600 serum samples from the DPT�1 cohort, as described in the experimental plan. In addition to this, the team at Henry Ford Health System will perform miRseq to define potential candidates that may be missed by the Exiqon platform.

Neurology

Principal Investigator: Gregory Barkley, M.D. Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (U01NS038455) Subcontract

There is a compelling need for prospective, properly controlled studies in women with epilepsy (WWE) during pregnancy to improve maternal and child outcomes. The proposed investigations are pertinent to the NINDS Epilepsy Research Benchmarks and will address multiple gaps in our knowledge noted by the recent American Academy of Neurology guidelines. This multicenter investigation will employ a prospective, observational, parallel-group, cohort design with an established research team. The specific aims are to: 1) Determine if WWE have increased seizures during pregnancy and delineate the contributing factors;2) Determine if C-section rate is increased in WWE and delineate contributing factors;3) Determine if WWE have an increased risk for depression during pregnancy and post-partum period and characterize risks factors;4) Determine the long- term effects of in utero AED exposure on verbal intellectual abilities and other neurobehavioral outcomes in the children of WWE;5) Determine if small for gestation age and other adverse neonatal outcomes are increased in children of WWE;6) Determine if breastfeeding when taking AEDs impairs the child's verbal intellectual and other cognitive abilities. An overall goal f the proposed research is to establish the relationship between AED exposure and outcomes in the mother and child as well as describe and explain the variability in AED exposure and response. Anticonvulsant blood levels (ABLs) and area-under-the- concentration-time- curves (AUCs) will be used as direct measures of drug exposure. The results will enable clinicians to prospectively calculate individual dosing regimens for the mother in order to optimize dosing and limit unnecessary drug exposure to the child. In addition, genetic samples will be collected, which will provide a valuable resource for future pharmacogenetics studies to further delineate individual variability across patients.

15 Principal Investigator: Jieli Chen, Ph.D. Neurorestorative Therapy of Stroke with HUCBC in Type Two Diabetic Mice (R01NS083078)

Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. Hyperglycemia and diabetes instigate a cascade of events leading to vascular endothelial cell dysfunction, increased vascular permeability and poor recovery after ischemic stroke. Diabetic animals exhibit more severely injured white matter (WM) than non-DM animals after stroke. There is lso a differential response to treatment of stroke between DM and non- DM subjects. Effective therapy of stroke in the non-DM population may not necessarily transfer to the DM population, prompting the need to develop therapeutic approaches specifically designed to reduce neurological deficits after stroke in the DM population. Our preliminary data show that T2DM significantly decreases microRNA- 126 (miR-126) and Angiopoietin-1 (Ang1) expression in the circulation and in the ischemic brain of mice.Human umbilical cord blood cell (HUCBC) treatment of stroke in T2DM mice starting at 3 days after stroke significantly improves recovery of neurological function as well as increases miR-126 and Ang1 expression in the ischemic brain. Therefore, based on our robust preliminary data, we propose to use HUCBCs for the treatment of stroke in the T2DM mice and to investigate the role of intercellular communication via miR-126 encapsulated within Exosomes/Microvesicles (EMVs) in mediating the therapeutic benefit on HUCBCs for ischemic stroke. This application includes three Aims. Aim 1 will test if miR-126 mediates HUCBC treatment induced neurorestorative effects after stroke in T2DM mice. We hypothesize that miR-126 mediates HUCBC treatment–induced vascular integrity, axonal outgrowth, and WM remodeling, and improves functional outcome after stroke in T2DM mice. Aim 2 will test whether miR-126 generated by HUCBCs is transferred to brain endothelial cells (BECs) and parenchymal cells via EMVs. We hypothesize that HUCBCs secrete EMVs containing miR-126 which are taken up by BECs and parenchymal cells. Aim 3 will investigate whether miR-126 regulation of Ang1 promotes the HUCBC-induced neurorestorative effects after stroke in T2DM mice. We hypothesize that: 1) HUCBC treatment of stroke in T2DM mice increases Ang-1 signaling activity in the ischemic brain; 2) miR-126 regulates Ang1 expression and thereby regulates vascular remodeling, axonal outgrowth and oligodendrocyte survival and differentiation; 3) Restoration of Ang1 with an Ang1 mimetic peptide will rescue the neurorestorative effects of knockdown of miR-126 in HUCBC after stroke in T2DM mice. In this application, we are the first to propose that, generation of miR-126 encapsulated in EMVs by HUCBCs contributes to its robust therapeutic restorative effects and that miR-126 and its regulation of Ang-1 mediate HUCBC- induced neurovascular and WM remodeling, and thereby improve stroke functional recovery in T2DM mice. This proposal is highly clinically relevant and if successful, will significantly impact the treatment of diabetic and possibly all stroke patients.

Principal Investigator: Jieli Chen, Ph.D. MiR-126/ABCA1 Mediates Exosome Induced Neurorestorative Effects after Stroke in T2DM Mice (1R01NS099030)

Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. Stroke in type two DM (T2DM) patients and in animal models increases vascular and white matter (WM) damage in the ischemic brain, and stroke in T2DM patients has a distinct clinical pattern and a poor prognosis compared to non-DM stroke. Exosomes (Exo), are active nano-size biological lipid containers, which transport regulatory genes and proteins between cells and form a major biological communication conduit, facilitating a plethora of biological responses. The regulatory molecules contained in the exosome include microRNAs (miRs), which regulate gene translation and play primary roles in mediating a vast range of biological functions. MicroRNA-126 (miR-126) is an angiogenic microRNA and primarily expressed in endothelial cells (EC). Specific conditional knockout of EC miR-126 (miR- 126EC-/-) mice have significantly worse functional outcome after stroke as well as decreased brain miR-126 and ATP-binding cassette transporter A1 (ABCA1) expression. Exosomes derived from EC (EC-Exo) have a high level of miR-126. Based on our robust preliminary data, in this pioneering study, we propose that treatment of stroke with EC-Exo will enhance neurorestorative effects after stroke in T2DM mice, possibly, via the miR-126/ABCA1 signaling pathway. This application includes three Aims. Aim-1: To test the therapeutic effects of EC-Exo on cerebral ischemic stroke in adult male and female T2DM mice. Aim-2: To evaluate whether miR-126 mediates EC-Exo treatment induced neurorestorative effects, we will evaluate the therapeutic effects of treatment of stroke in specific

16 conditional knockout of EC miR-126 (MiR-126EC-/-) and in non-miR-126 knockout control (miR- 126fl/fl) T2DM mice with EC-Exo derived from miR-126EC-/- brain ECs (miR-126EC-/- EC-Exo) or EC- Exo derived from wild type miR-126fl/fl brain ECs (miR-126fl/fl-EC-Exo) on vascular and axonal/WM remodeling and neurological and cognitive functional outcome. Aim-3: To test whether ABCA1, an indirect target of miR-126, contributes to EC-Exo treatment induced neurorestorative effects after stroke in adult male T2DM mice, mice with specific knockout of brain ABCA1 (ABCA1-B/-B) and WT ABCA1 knockout control (ABCA1fl/fl) mice will be employed. In this application, we are the first to propose that, generation of miR-126 encapsulated in EC-Exo contributes to its robust therapeutic restorative effects and that miR- 126/ABCA1 pathway mediates EC-Exo-induced neurovascular and WM remodeling, and thereby improves stroke neurological and cognitive functional recovery in T2DM mice. This proposal is highly clinically relevant and if successful, will significantly impact the treatment of diabetic stroke, and possibly all stroke patients.

Principal Investigator: Michael Chopp, Ph.D. miR-17-92 Exosome Treatment of Stroke (R01NS088656)

Exosomes, small lipid microvesicles (30-150 nm), are active biological containers, which transport regulatory genes and proteins between cells and form a major biological communication conduit, facilitating a plethora of biological responses. The regulatory molecules contained in the exosomes include microRNAs (miRNAs), short (22-25 nt) non-coding RNAs which regulate gene translation and play primary roles in mediating a vast range of biological functions. In this proposal, based on strong preliminary data, we propose to manufacture a distinct exosome population which contains increased levels of the miR- 17-92 cluster as a proof-of-principle and a mechanistic demonstration of a new method of treating stroke and possibly other neurological diseases and injury. We test the premise, that by modulating their miRNA content, exosomes can be designed to enhance plasticity of axons and thereby further promote neurological recovery post stroke. Success of this novel approach may lead to a new designer-based paradigm for the treatment of stroke and neurological disease. The following Specific Aims and associated Hypotheses are proposed: Specific Aim 1: To employ exosomes derived from multipotent mesenchymal stromal cells (MSCs) to treat stroke in order to enhance neurovascular remodeling and thereby, functional recovery post stroke. Hypothesis: Exosomes, derived from MSCs when administered to rats after stroke promote neurovascular remodeling which improves functional outcome. Specific Aim 2: To alter specific miRNAs contained within exosomes generated by MSCs as a means to enhance axonal plasticity and neurological recovery post stroke. Hypothesis: Administration of exosomes with increased miR-17-92 cluster to rats post stroke promotes axonal remodeling and enhances functional outcome. There are multiple layers of innovation in our application: we generate biological exosome carriers tailored for specific miRNAs; we use these exosomes to treat stroke, without the administration of exogenous cells; we employ electrophysiological methods, laser capture, fiber track tracing, a battery of neurological tests, and an array of novel approaches, e.g. microfluidic chambers, and ex vivo slice cultures, to mechanistically determine the molecular pathways of the target exosomes which mediate axonal outgrowth. Development of this designer exosome-based therapy, also serves as a prototype for capitalizing on the characteristics of exosomes to transport specific miRNAs and for the manufacture of designer exosomes. Developing a therapy for stroke that is exosome-based opens up a wide variety of means to deliver targeted regulatory genes to enhance multifaceted aspects of central nervous system (CNS) plasticity and to amplify neurological recovery for neural injury and neurodegenerative diseases.

Principal Investigator: Xu Cui, Ph.D. ABCA1 Regulates White Matter Remodeling and Oligodendrogenesis after Stroke (R01NS092917)

Stroke is a major cause of white matter (WM) damage which induces long-term disability. There is limited WM remodeling in the adult brain. Many neuroprotective treatments of stroke have failed in clinical trials because they cannot protect WM. Therefore, there is a compelling need to investigate the mechanism underlying WM remodeling and oligodendrogenesis of the adult brain and to develop

17 effective long-term stroke therapy. Cellular cholesterol modulates axonal and dendritic outgrowth and is required for myelination. The level of HDL-cholesterol is related to the progression and recovery of stroke patients. ATP-binding cassette transporter A 1 (ABCA1) is a major cholesterol transporter and plays critical roles in regulation of HDL- cholesterol and ApoE synthesis and metabolism in the central nervous system. Brain specific- ABCA1 deficient (ABCA1-B/-mice have very low brain HDL- cholesterol/ApoE level, and exhibit neuronal ultrastructure changes and functional deficits. Both HDL- cholesterol and ApoE increase neurite outgrowth in culture conditions. Our preliminary study shows that ABCA1-B/-B mice exhibited increased WM damage and reduced oligodendrogenesis and exacerbated neurological functional deficits after stroke. Primary cultured neurons derived from ABCA1- B/-B mice show decreased neurite outgrowth, which can be attenuated by HDL treatment. ABCA1-B/-B astrocyte- conditioned media also decreased wild type neurite outgrowth after hypoxic ischemia. Therefore, we propose the following three specific aims: Aim1 To investigate whether brain-deficient in ABCA1 exhibits decreases in WM-remodeling and axonal growth after stroke. ABCA1-B/-B and floxed-control mice will be subjected to stroke, WM-changes and oligodendrogenesis will be measured. Aim2 To investigate molecular mechanism underlying ABCA1 in regulation of WM-remodeling and oligodendrogenesis after stroke, we will examine whether ABCA1 regulates brain HDL and ApoE level, and whether brain HDL and ApoE levels mediate ABCA1-induced WM-remodeling and oligodendrogenesis after stroke. Aim3 To investigate cellular mechanisms of ABCA1 in regulation of WM- remodeling and oligodendrogenesis, we will examine neurons and oligodendrocytes and the cross talk of astrocytes with neurons and oligodendrocytes on ABCA1-induced WMremodeling and oligodendrogenesis in vitro and in vivo. We expect that ABCA1 deficient brain will exhibit significant decreases in HDL and ApoE level, and decreases WM-remodeling and oligodendrogenesis as well as reduced functional outcome after stroke. The level of HDL/ApoE in brain or cerebrospinal fluid will, at least partially, mediate ABCA1-induced WM-remodeling and oligodendrogenesis in the ischemic brain after stroke. To our knowledge, no one has investigated the functional effect of ABCA1 on oligodendrogenesis and WMremodeling post- stroke recovery, especially by using ABCA1- B/-B mice. The new insights gleaned from this study will contribute to our understanding of the beneficial role of ABCA1/HDL-C/ApoE in brain plasticity which will impact development of rational restorative approaches to improve neurological outcome for stroke patients.

Principal Investigator: Shailendra Giri, Ph.D. Role of AMP-Activated Protein Kinase in Bacterial Endophthalmitis (R01EY026964) Subcontract

The role of myeloid cells such as neutrophils in providing host defense to microbial infections is well- established; however, the contribution of monocytes/macrophages (M¿) to the pathophysiology of bacterial endophthalmitis is less clear. Our preliminary studies revealed that M¿ depletion results in increased inflammatory mediators at the resolution phase, suggesting their involvement in the resolution of endophthalmitis. The M¿ perform multiple tasks, including sensing pathogens, tissue repair, and, in response to host-derived mediators, they differentiate into distinct functional phenotypes; a feature termed "plasticity". The "classically activated" M¿ (M1) produce inflammatory cytokines and nitric oxide, contributing to host tissue damage. Conversely, the "alternatively activated" M¿ (M2) mediate tissue repair through the elimination of damaged cells/tissue and the production of anti-inflammatory molecules to resolve inflammation. Therefore, understanding the mechanisms governing the phenotypic switch of M¿ can be utilized to develop novel therapeutic strategies. Our transcriptome and metabolomics analyses of the bacteria-infected retina directed us to the identification of adenosine monophosphate- activated protein kinase (AMPK), a metabolic gene, which modulates the infiltrating myeloid cell phenotype in endophthalmitis. We discovered that mice with global deletion (knockout) of AMPKa1 (KO) developed severe endophthalmitis and pathology compared to wild type (WT) mice. M¿ lacking AMPKa1 maintained a low metabolic state, even in the hyper-inflammatory state. To precisely examine the role of AMPK in myeloid cells, we induced endophthalmitis in myeloid cell specific KO of AMPKa1 (LysM-KO) and observed that LysM-KO displayed exacerbated inflammation and reduced retinal function compared to WT mice, suggesting an essential role of AMPK in myeloid cells in the pathogenesis of bacterial endophthalmitis. Building on these findings, we propose to test our central hypothesis that AMPK exerts protective effects in bacterial endophthalmitis by modulating the polarization of infiltrating monocytes/M¿ to promote inflammation resolution and that metabolic reprograming is an underlying mechanism of the

18 monocytes/M¿ phenotype switch. To test our hypothesis, in Aim 1, we will investigate the mechanisms underlying reduced AMPK activity in bacterial endophthalmitis by examining the modification of LKB1 via nitrosylation or chemical adduct formation. Aim 2 tests the hypothesis that AMPKa1 ablation enhances the activation state of myeloid cells and maintains their proinflammatory (M1) state during the resolution phase of the disease. In Aim 3, we will decipher the bioenergetic events, regulated by AMPK in M¿, that polarize and maintain their pro-inflammatory nature. The anticipated results of this study will demonstrate that defective AMPK activity in myeloid cells, mainly in monocytes/M¿¿ impacts the resolution of endophthalmitis via regulation of cellular metabolism. Also, it may provide novel therapeutic targets for the development of anti- inflammatory therapies for endophthalmitis and other microbial infections.

Principal Investigator: Quan Jiang, Ph.D. Impairment of the Glymphatic System in the Aged Diabetic Brain (R21AG052735)

Type II diabetes mellitus (T2DM) is a common metabolic disease and an established risk factor for cognitive dysfunction in the elderly population. However, the pathological mechanisms that underpin the development and progression of DM-related deficits remain unclear. Recent investigations1-4 have altered the traditional model of cerebrospinal fluid (CSF) hydrodynamics. The brain lacks specialized organ-wide anatomic structure to facilitate lymphatic clearance although the brain has complex architecture and high metabolic activity. However, a newly identified glymphatic system has been shown to modulate the CSF-interstitial (ISF) exchange, which facilitates clearance of interstitial solute from the brain parenchyma. Impairment of the glymphatic system is involved with the development of neurodegenerative conditions, including Alzheimers disease and sleep disorders, etc2, 4. Although the impact of the glymphatic system is being investigated in Alzheimers disease and sleep disorders, with promising results, there are no reported data related to diabetes and the glymphatic system. Using a model of T2DM in middle- aged rats and noninvasive MRI methodologies, our preliminary data indicate that compared with age-matched non-DM rats, the T2DM rats reduced clearance rate of interstitial Gd- DTPA agent from brain parenchyma by approximately 84 % and increased clearance time by 4.2 time of Non- DM rats in the hippocampus, leading to accumulation of Gd-DTPA agent in these regions and consequently high MRI signal intensity in T1 weighted MRI (T1WI). In parallel, ex-vivo confocal imaging analysis revealed that in Non-DM rats, the concentration of interstitial Texas Red-conjugated dextran (TR-3, MW 3kD) reached a plateau in the brain interstitium approximately 3h after injecting TR-3 into the cisterna magna and after that TR-3 began to clear and was almost completely cleared from brain parenchyma at 6h after the injection, whereas in middle-age T2DM rats TR-3 accumulated in the hippocampal interstitium with time and exhibited strong fluorescent signals at 6h after the injection. These ex-vivo data are consistent with in vivo MRI findings, indicating that T2DM impairs the glymphatic clearance of interstitial solutes in the brain. In addition, T2DM rats exhibited microvascular thrombosis and blood brain barrier (BBB) leakage in the hippocampus in immunofluorescent analysis and also showed spatial learning deficits compared to Non-DM rats. Based on our novel preliminary data, we will employ MRI and 3D confocal microscopy to evaluate for the first time, temporal and spatial profiles of paravascular CSF-ISF exchange throughout the brain during the development of T2DM. We propose to further develop MRI protocol and analysis modeling as an effective means to evaluate the function and status of the glymphatic system (Aim 1). We will then use the optimized MRI protocol and analysis to explore the relationships between impairment of glymphatic system, vascular damage, and functional deficits during develop of DM (Aim 2). Data generated from this application will provide new insights into the progression of DM associated impairment of the glymphatic system.

Principal Investigator: Quan Jiang, Ph.D., Jieli Chen, Ph.D. Investigation of D4-F Effects on Neurovascular Remodeling after Diabetic Stroke (R01NS097747)

Ischemic stroke patients with Diabetes mellitus (DM) exhibit a distinct risk-factor and etiologic profile and a worse neurovascular prognosis than non-DM patients. Therefore, there is a compelling need to investigate neurovascular changes after stroke in the DM and non-DM population and to develop therapeutic approaches specifically designed to reduce neurological deficits after stroke. Type 2 diabetes (T2DM) constitutes 90% of diabetic patients and is associated with low high-density lipoprotein cholesterol (HDL-C), impairment of the anti-oxidative capacity of HDL-C, low phosphorylation of

19 endothelial nitric oxide synthase (p-eNOS), and with reduced ATP-binding cassette transporter A1 (ABCA1) gene expression. D-4F is an economical apolipoprotein A-I (ApoA-I) mimetic peptide, presently employed in clinical trials to reduce coronary atherosclerosis in patients with acute coronary syndrome. However, the therapeutic effects of D-4F in post-ischemic stroke have not been investigated. Our preliminary data show that D-4F treatment of stroke starting 2h or 24h after ischemic stroke improves recovery of neurological function in both T2DM and non-DM mice and also increases p-eNOS and ABCA1 in the ischemic brain. In a novel and clinically relevant approach, based on our robust preliminary data, we propose to use D-4F in the treatment of stroke in the non-DM and T2DM population in mice. We seek to develop D-4F as a novel neurorestorative therapy to reduce white matter (WM) dysfunction and vascular damage, in T2DM and non-DM mice when treatment is initiated at 24h after onset of ischemic stroke. In addition, most development of stroke treatments has focused on young adult animals, but not on old animals, the prevalent population with stroke. Increased age also increases neurological impairment after stroke. We have also developed and implemented multimodality MRI imaging which can dynamically monitor neurovascular remodeling in both the animal and the patient. In the current study, we will measure WM and vascular changes and elucidate the mechanisms of action of D-4F in young adult and aged animals with and without T2DM after stroke. Our hypothesis is that D-4F increases ABCA1 and p-eNOS signaling activity which mediates vascular and WM remodeling and in concert improve functional outcome after stroke. We, therefore, propose two highly integrated and longitudinally designed Specific Aims. Aim 1 will investigate the delayed (24h after stroke) therapeutic effects of D-4F in non-DM and T2DM in young adult and aged mice after stroke. The differences in cerebral WM and vascular changes, and neurological functional outcome after stroke between non-DM and T2DM mice treated with or without D-4F will be analyzed. MRI will be employed to measure the dynamics of neurovascular reorganization underlying therapeutic response and recovery. In Aim 2, using eNOS knockout mice and specific loss of brain ABCA1 mice, we will investigate the mechanisms by which D-4F promotes neurovascular remodeling and hence, neurological recovery. The long-term objective of this RO1 is to develop a neurorestorative treatment for stroke in patients with or without diabetes.

Principal Investigator: Quan Jiang, Ph.D. Glymphatic and Cognitive Impairment of Aging and Diabetes (RF1AG057494)

The objective of this application is to investigate glymphatic impairment and cognitive deficits during progression of aging with and without diabetes. Emerging data1-5 indicate that the glymphatic system in the brain mediates the cerebrospinal fluid (CSF)-interstitial (ISF) exchange and solute clearance from the brain parenchyma. However, despite the well-described dysfunction of the glymphatic system in the development of neurodegenerative conditions, there is still no reported study that focuses on the role of the glymphatic system in the development of cognitive impairment during aging and aging with type-2 diabetes (DM). Using noninvasive MRI methodologies to investigate cerebral solute waste clearance in middle-age control and type-2 diabetic (DM) rats, we have found increased impairment of the glymphatic system, as indicated by reduced clearance of interstitial Gd-DTPA in brain parenchyma, primarily in the hippocampus and hypothalamus in DM rats (Fig.2&3). In parallel, 3D confocal microscopic analysis of the brain-wide distribution of fluorescent tracers revealed increased delayed clearance of ISF in the hippocampus and hypothalamus from DM rats (Fig.2&3). Impairment of the glymphatic system in DM rats was shown to be highly correlated with cognitive deficits as measured by an array of cognitive tests including the Morris Water Maze (MWM) for hippocampal related learning and memory. Importantly, histopathological analysis shows that delayed clearance of interstitial solutes is associated with sporadic cerebral microvascular thrombosis in the hippocampus 2 months after hyperglycemia (15 months from birth), while extensive microvascular thrombosis and para-vascular accumulation of beta-amyloid (Aβ) are detected at 4 months after induction of hyperglycemia (17 months from birth), suggesting that the impairment of the glymphatic system leads to Aβ accumulation. Collectively, our preliminary data, for the first time, demonstrate that non-invasive MRI methodologies can detect DM-induced early impairment of the glymphatic system which is highly correlated with hippocampal related dysfunction of learning and memory. Based on our novel preliminary data, we will employ MRI and 3D confocal microscopy to evaluate and quantitatively measure kinetic clearance parameters of the glymphatic system during progression of aging with and without DM(Aim 1). We will then investigate: whether impairment of the glymphatic system predicts cognitive dysfunction, the sensitivity and association between impairment of

20 the glymphatic system, the onset of brain vascular dysfunction, and cognitive deficits during aging with and without DM (Aim 2). Data generated from this application will provide new insights into aging and age-matched DM associated impairment of the glymphatic system and the relationship of the glymphatic system with vascular and cognitive dysfunction.

Principal Investigator: Xianshuang Liu, M.D. Translational Study of miR-146a Gene Therapy for Diabetic Peripheral Neuropathy (R01DK102861)

Peripheral neuropathy is the major complications of diabetes. There is a compelling need to develop effective therapeutic approaches specifically designed to improve neurological function in the damaged peripheral nervous system after diabetes. MicroRNA-146a (miR- 146a) has been implicated in the regulation of multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. In a novel set of experiments, our preliminary data show that intravenous administration of miR-146a remarkably improved sciatic nerve vascular function, axonal myelination and peripheral nerve function in diabetic mice, indicating that miR-146a may have a beneficial effect on the clinical treatment of DPN. In this application, we therefore seek to investigate the mechanisms underlying the therapeutic effects of miR-146a on DPN. We propose that miR- 146a by improving vascular function and suppressing pro-inflammation factors ameliorates DPN. The associated hypotheses are: 1. Treatment with chemically engineered miR-146a improves neurological outcomes in DPN in dose and therapeutic window dependent manners. 2. Elevation of miR-146a levels suppresses its target genes, IRAK1/TRAF6 and their down-stream pro-inflammatory factors in vascular endothelial cells and monocytes of type II diabetic mice, thereby, leading to the improvement of neurovascular function and consequently ameliorating peripheral neuropathy. To investigate the effect of miR-146a on neurological outcomes, type II diabetic mice which develop severe peripheral neuropathy will be treated with miR-146a at various time points and doses after onset of DPN. To investigate the underlying molecular mechanisms, the effects of miR-146a overexpression and knockdown on target genes and inflammatory genes that mediate miR- 146a-enhanced neurovascular function will be determined. These studies are innovative and will provide novel insights into mechanisms underlying the neurological dysfunction of DPN and likely lead to the development of a new miRNA-based gene therapy.

Principal Investigator: Hongqi Xin, Ph.D. Exosome Transfer of miR-133b Mediates MSC Induced Neurological Recovery after Stroke (R01NS081189)

Multipotent mesenchymal stromal cells (MSCs) have potential therapeutic benefit in many diseases including neurological diseases and injury. MSC-based therapies enhance recovery from stroke. We have previously demonstrated that exogenously administered MSCs interact with neural cells, increase the production of neurites, reduce expression of axonal inhibitory molecules and stimulate the production of growth and plasticity positive factors in neural cells which promote neurorestoration and recovery of neurological function. However, it is unknown how MSCs interact with neural cells, alter their protein expression, and thereby promote functional recovery. In the present proposal, we provide fundamental and novel mechanistic insight into how cell-based therapies promote recovery. MicroRNAs (miRNAs) act as master switches regulating the translation of many genes, and exosomes are membrane vesicles, 40-100nm in diameter, that are secreted by a wide range of cell types. We propose that MSCs increase specific miRNA levels in neural cells via exosomes, which subsequently stimulate neurite outgrowth and functional recovery. Based on our preliminary data, we will primarily focus on miR-133b, as an important target miRNA. Two specific aims are proposed. Aim 1: To investigate whether exosomes primarily mediate cell-cell communication by direct transfer of miR-133b to neural cells and/or indirectly by stimulating miR-133b expression in neural cells, which subsequently promote neurite outgrowth and functional recovery after stroke. Aim 2: To investigate the mechanisms by which miR-133b promotes neurite remodeling after treatment of stroke with MSCs. This study opens up important and novel ways to elucidate how exogenously administered cells communicate with and alter neural cells to activate restorative events. Confirming our hypothesis represents a major leap forward in our understanding of cell-cell communication and will lead to novel ways to augment brain

21 recovery.

Principal Investigator: Li Zhang, M.D. Combination Treatment with Vepoloxamer and tPA for Acute Stroke (R01NS102744)

Stroke is one of leading causes of death and disability worldwide, mainly affecting elderly. Tissue plasminogen activator (tPA), the only Food and Drug Administration (FDA) approved treatment, is limited in its use to < 8.5% of stroke patients. Therefore, there is a compelling need to develop new and broader utility therapies for acute ischemic stroke. Vepoloxamer is a well characterized proprietary amphipathic copolymer with rheological properties, which is currently under investigation in a global phase III clinical trial for patients with sickle cell disease. Our preliminary studies demonstrate that administration of Vepoloxamer in combination with tPA 4h after embolic stroke facilitates recanalization and thrombolysis reduces ischemic neuronal damage and improves neurological outcome, but does not increase cerebral hemorrhage in young adult rats. We also found that platelet-derived exosomes contribute to the therapeutic effect of Vepoloxamer on enhanced tPA-thrombolysis. In this application, we propose to investigate effect of Vepoloxamer in combination with tPA on acute stroke and molecular mechanisms underlying the combination therapy on the thrombolysis and neurovascular function in the aged male and female rats. Data generated from this application may provide a novel and potentially useful treatment strategy for patients with acute stroke.

Principal Investigator: Li Zhang, M.D. Cerebral Endothelial Derived-Exosomes Improve Cognitive Function in Aged Diabetic Rat (R56AG055583)

Diabetes mellitus (DM) is a common metabolic disease in the middle-aged and older population, which is associated with cognitive decline and an increased risk of developing dementia in the elderly. Given the growing size of the aging population and increased prevalence of DM, development of specific interventions to maintain cognitive integrity by counteracting DM induced pathophysiological processes is of major clinical importance. Clinical trials show that the achievement of improved glycemic control may not prevent progression of cognitive impairment. The underlying cause of DM-induced cognitive deficits remains unknown. Exosomes are nanovesicles with a size of 40 to 120 nm in diameter and mediate intercellular communication by transferring proteins, lipids, and genomic materials including mRNAs and microRNAs (miRNAs) between source and target cells. Our preliminary data demonstrated aged-DM rats exhibit substantial cognitive impairment, which is associated with dysfunction of cerebral endothelial cells and neural stem cells. We also found that exosomes derived from dysfunctional cerebral endothelial cells induced by DM communicated with and damaged neural stem cells. More importantly, administration of exosomes isolated from cerebral endothelial cells of healthy young adult brain to aged-DM rats effectively improved cognitive function and minimize DM-induced dysfunction of cerebral endothelial cells and neural stem cells. In this application, we therefore, propose to develop the endothelial exosomes as a mechanism-based therapy for DM-induced cognitive decline in aged population. Our hypotheses are: 1) The cerebral endothelial exosome (CEE) treatment reduces cognitive deficits in the aged-DM rat, 2) The CEE treatment improves cerebral vascular patency and integrity, and promotes neurogenesis and oligodendrogenesis in the aged-DM rat, and 3) Engineered exosomes carrying elevated miR-1 and -146a have enhanced effects on cerebral vascular function, neurogenesis and oligodendrogenesis as well as cognitive function. Aim 1 is to investigate whether the CEE derived from young adult rats improve cognitive function in the aged-DM rat, when the CEE is administered at an early (2 months) or advanced (4 months) stage of DM in aged male and female rats. Aim 2 is to investigate whether the CEE treatment improves cerebral vascular function and enhances neurogenesis and oligodendrogenesis in the aged-DM rat. Cerebral vascular patency and integrity, neurogenesis and oligodendrogenesis will be measured. Aim 3 is to investigate whether treatment of the aged-DM rat with tailored endothelial exosomes carrying elevated miR-1 and miR146a further enhances vascular function, neurogenesis and oligodendrogenesis as well as cognitive function. We will generate the tailored CEE and then administer the tailored CEE to aged-DM rats. These studies are innovative and highly clinically relevant.

22 Principal Investigator: Zheng Gang Zhang, M.D., Ph.D. Ac-SDKP for Treatment of Acute Stroke (R01NS079612)

Stroke is a leading cause of death and disability worldwide and approximately 72% of people who suffer a stroke are over the age of 65. Tissue plasminogen activator (tPA) is the only drug approved by the Food and Drug Administration (FDA) for treatment of acute stroke (within 4.5h). The most feared complication after tPA treatment of stroke is an increased risk of cerebral hemorrhage. Our preliminary data indicate that N- acetylseryl- aspartyl-lysyl-proline (Ac-SDKP), a peptide normally presented in human plasma, in combination with tPA reduced infarct volume by more than 50% and improved neurological outcome, but did not increase the incidence of hemorrhagic transformation in young adult rats. In this application, we propose to develop a combination therapy of Ac- SDKP and tPA for treatment of acute stroke in aged rats and to investigate molecular mechanisms underlying the combination therapy on the neurovascular unit. In Specific Aim 1, using MRI and 3D laser confocal microscopy, we will investigate the effect of Ac-SDKP alone and Ac-SDKP in combination with tPA on recanalization of the occluded MCA, cerebral microvascular perfusion and vascular integrity, brain hemorrhage, and ischemic neuronal damage in aged rats subjected to embolic middle cerebral artery occlusion (MCAO). In Specific Aim 2, we will examine whether Ac-SDKP suppresses the ischemia- and tPA-activated nuclear transcription factor-κB (NF-ĸB) pathway in cerebral vessels, which leads to enhancement of cerebral microvascular patency and integrity by reduction of thrombosis. In Specific Aim 3, we will examine whether Ac-SDKP blocks the ischemia- and tPA- activated transforming growth factor β (TGFβ) signaling pathway in cerebral vessels and astrocytes, which leads to reduction of thrombosis by down regulation of plasminogen activator inhibitor1 (PAI- 1). These studies could potentially provide a new therapy to minimize the adverse effect of tPA on ischemic neurovascular damage, leading to improved neurological outcomes after acute stroke.

Neurosurgery

Principal Investigator: Meser Ali, Ph.D. Treatment of Glioma with Nanocombretastatin with MRI Monitoring (R01CA206190)

Glioblastoma (GBM) is a highly aggressive hypervascularized brain tumor characterized by high recurrence rates and poor prognosis despite advanced treatment. The vasculature of GBM is fundamentally different from that of normal vasculature and offers a unique target for anti-cancer therapy. Therefore, direct targeting of tumor vasculature with vascular disrupting agents (VDAs) is distinctly different from anti-angiogenic strategies, and offers a complementary approach to standard therapies. Combretastatin A4 (CA4) is a potent vascular disrupting drug. CA4 induces rapid shutdown of tumor blood supply, typically promoting a necrosis at the core of the tumor, but leaves a rim of viable tumor cells at the periphery which can then rapidly re-grow. However, CA4 is not effective in inducing necrosis at the core of GBM tumor. The ineffectiveness of small molecule chemotherapy drugs in treating malignant brain tumors has been attributed to the blood-brain barrier (BBB) being a significant impediment to the transvascular extravasation of drug fraction across the barrier into the extravascular compartment of tumor tissue and the high tumor interstitial fluid pressure also presents an additional delivery barrier. Nanotechnology is already benefiting to deliver drugs across the BBB and into brain tumors. We have engineered a nano-sized polymeric CA4 conjugate which demonstrates high water solubility. Preliminary intravenous (i.v.) delivery of G3-CA4 in an orthotopic glioma model demonstrated necrosis at the core of the tumor leaving a rim of viable tissue. By applying the designed nano-prodrug strategy and tumor-specific prodrug activation mechanism, we observed the true success of inducing necrosis at the core of the tumor in an orthotopic U-251 glioma animal model first time. Tumor-VDAs have significant potential when combined with cytotoxic chemotherapy and radiotherapy in treating other tumor models. Combined treatment with radiation is attractive, as radiation therapy (RT) represents a standard of care and RT should effectively kill the well-oxygenated cancer cells in the well-perfused tumor rim. We have shown that GBM cancer stem cells are sensitive to radiation exposure in culture and a single dose of 50Gy irradiation yielded necrosis in primary GBM rat model. Therefore, this study is extended to include SRS and standard cytotoxic temozolomide (TMZ) therapies with G3-CA4. We hypothesize that the combination of G3-CA4 with SRS and TMZ will show synergistic cytotoxic effect in

23 clinical relevant primary GBM model. Our objectives of the proposed research are A) To incorporate CA4 molecules with dendrimer-based nanoparticles (G3-CA4) that demonstrates full solubility in aqueous media, B) To determine the efficacy and safety of small molecule CA4, CA4-P and G3-CA4 nano-prodrug in U251 glioma tumor model, C) To determine the efficacy and safety of G3-CA4 alone or in combination with SRS in primary GBM, D) To determine the efficacy and safety of a combined G3- CA4 and standard TMZ therapy in primary GBM model. The overall therapeutic effect from G3-CA4 alone or in combination with SRS/TMZ will be evaluated by image-guided MRI monitoring of long-term survival rats.

Principal Investigator: Meser Ali, Ph.D. Extracellular pH Mapping as Therapeutic Readout of Nanoparticle-based Drug Delivery in Glioblastoma (R01EB023366) Subcontract

Extracellular acidosis (i.e., low pHe) is a tumor microenvironment hallmark, caused by atypical metabolism and perfusion. Acidic pHe enhances cancer growth, proliferation, and builds therapy resistance. The prognosis remains dismal for most brain tumor patients. Malignant gliomas, including glioblastoma multiforme (GBM), fail treatments because gliomas invade outside tumor boundaries conventionally demarked by MRI contrast and the blood-brain barrier (BBB) blocks most drugs. Furthermore conventional MRI methods are insensitive to physicochemical parameters like pHe and mainly track intratumoral volume. Among the primary MRI methods are paramagnetic agents for longitudinal (T1) contrast, where assessment of treatment response involves 2D or 3D measurement with Gd3+ enhanced MRI contrast. However, such methods are not reliable in distinguishing pseudoprogression and pseudoresponse from actual changes in tumor status. Thus there is an urgent need for alternative MR techniques sensitive to metabolic changes, which can aid in effective monitoring of therapeutic response in addition to measuring the tumor size. Because acidic pHe milieu is conducive to tumor growth and builds resistance to therapies, simultaneous mapping of pHe inside and outside the tumor (i.e., intratumoral-peritumoral pHe gradient) is an important cancer imaging need. A novel way to map intratumoral-peritumoral pHe gradient is using lanthanide III (Ln3+) agents with BIRDS methods, where physicochemical factors like pHe contribute to shifts of non-exchangeable protons. To meet the need for MR readouts of the tumor physicochemical state, we developed BIRDS to map the intratumoral-peritumoral pHe gradient, and found that it is a sensitive readout of cancer growth and treatment. Based on preliminary data obtained from GBM models (e.g., U251), including patient-derived xenograft (PDX) models, we will validate high-resolution pHe mapping with BIRDS as therapeutic readout of chemotherapy drugs delivered into human GBM models. Although we detected 1-2 mm diameter tumors with BIRDS using non-methylated agents, higher resolution mapping of intratumoral- peritumoral pHe gradients will be reached with a novel methylated multiplexed agent in Aim 1. In Aim 2 we will validate intratumoral-peritumoral pHe gradient mapping by BIRDS with fluorescent pHe probes. We will use BIRDS to examine how intratumoral-peritumoral pHe gradients change with tumor aggression (Aim 3). We will also test compatibility of pHe mapping with BIRDS for tracking response to chemotherapy drugs (e.g., Temozolomide and Sorafenib) being used to treat GBMs (Aim 4). Both of these drugs are known to cross the BBB and are used in GMB therapy. Temozolomide activates apoptosis by alkylating DNA to stall cell replication and Sorafenib is a multiple kinase inhibitor targeting several oncogenic pathways and enhances glycolysis. If successful, pHe mapping by BIRDS will enable monitoring of therapeutic response of various chemotherapy drugs for preclincal PDX models to potentially be translated clinically.

Orthopaedics/Bone & Joint

Principal Investigator: Yener Yeni, Ph.D. A Clinically Viable Noninvasive Method for Direct Measurement of Mechanical Strains in Vertebral Bone (R21AR070363)

Mechanical strains experienced at the tissue level are intimately related to the mechanical integrity of whole bones and their response to environmental and interventional stimulus. Techniques for measurement of trabecular strains in an entire cancellous bone volume have been developed for

24 laboratory studies of excised bones that can be performed using high resolution imaging systems such as microcomputed tomography (μCT). These methods involve comparing high-resolution images of bones taken under loaded and no-load conditions and, through advanced mathematical computations, calculation of tissue strains (digital volume correlation, DVC). Thus far, it has not been possible to apply DVC methodologies to human spines in vivo, due to issues with resolution, radiation exposure and the need for a safe, yet effective mechanical loading protocol within the clinical imaging modality. Modern digital tomosynthesis (DTS) systems have the characteristics needed to be able to perform strain mapping in vivo but this has never been tried. With the overall hypothesis that DTS-based strain mapping is feasible and informative, the following aims are proposed to rigorously optimize, validate and demonstrate utility in human spine through a set of in vitro and in vivo experiments: Aim 1: Identify the strain levels that can be measured with DTS-DVC under physiologically relevant load magnitudes by using human cadaveric vertebral bodies and comparison to μCT based DVC μCT will serve as the gold standard for optimizing values of DVC analysis parameters for a DTS application, determining thresholds for admissible strain values to maximize measurement accuracy and precision and identifying strain components to be further validated in the later stages of the research. Aim 2: Determine the extent to which DTS-DVC performed under a clinically applicable loading protocol predict vertebral strength and energy to failure independent from bone density. Using in vitro destructive mechanical test results as gold standard outcome, this aim will determine the relative efficacy of strain components for improving prediction of mechanical failure in cadaveric vertebrae and define margins of error for these predictions. Aim 3: Determine the range of in vivo vertebral strains measured with DTS-DVC in a sample of human subjects with a vertebral deformity and those without. Testing the ability of DTS-DVC to discriminate between cases with a predictable strain outcome from those that are normal will provide in vivo proof of concept. Through comparison of in vivo and in vitro strains, it will be possible to estimate the error in predictive models to be tested in future clinical studies. Development of the DTS-DVC methodology through the proposed aims is expected to substantially improve understanding of etiologies of age- and disease-related bone and joint degeneration, assessment of fracture risk and assessment of efficacy of therapeutic and surgical interventions aiming to restore bone function.

Pathology

Principal Investigator: Azadeh Stark, Ph.D., Molecular Markers of Risk of Subsequent Invasive Breast Cancer in Women with Ductal Carcinoma In Situ (R01CA218429) Subcontract

Ductal carcinoma in situ (DCIS) is considered to be a non-obligate precursor of invasive breast cancer (IBC). Use of screening mammography has led to a substantial increase in detection of DCIS over the past 2-3 decades. About 5-14% of patients diagnosed with DCIS and treated with breast-conserving therapy, with or without radiation, develop an ipsilateral IBC and 1-6% develop a contralateral IBC over a period of 10 years. However, natural history studies have shown that, in the absence of treatment, 14- 53% of DCIS cases develop IBC if followed for up to ~30 years. Treatment of DCIS is variable, and many DCIS patients are either under- or over-treated. Elucidation of the molecular changes detectable in DCIS lesions that are associated with risk of IBC development is critically needed, as this may help not only to reduce risk of development of IBC but also to prevent overtreatment of patients with lower risk of IBC. In this regard, a multigene expression assay, consisting of genes related to proliferation, as well as PR and GSTM1, was recently shown to predict risk of subsequent ipsilateral IBC in women with DCIS. Similarly, immunohistochemically-detected expression of p16, COX-2, and Ki67 has also been associated with increased risk of IBC development. However, these findings require confirmation. Furthermore, novel prognostic (and ultimately predictive) markers may emerge from assessment of gene expression patterns on a global scale. In this regard, microRNAs (miRNAs), which are noncoding RNAs that are master regulators of gene expression, are thought to contribute to the development of invasive cancer. Against this background, our overarching goal is to facilitate early detection of patients with DCIS at risk of IBC development. To this end, building upon our previous work, we propose to use clinical data and archived formalin-fixed paraffin-embedded (FFPE) tissue from a large, population- based multi-center cohort of 7,275 patients initially diagnosed with DCIS in community-based health plans and followed for subsequent IBC development, to identify and then validate miRNA expression changes associated with risk of subsequent IBC, to evaluate risk of IBC in association with 2 previously

25 identified sets of markers (Oncotype DX DCIS score; positivity for p16, COX-2, and Ki67 protein expression), and to examine the association between clinical factors and risk of subsequent IBC in the largest such study to date. Our molecular epidemiologic study, which proposes to apply state-of-the art technologies to archived DCIS FFPE specimens for the detection of molecular changes associated with risk of IBC development in a large, multi-center population-based cohort of women initially diagnosed with DCIS, has the potential to lead to approaches that will help to refine identification of women who need enhanced surveillance and early aggressive treatment.

Radiation Oncology

Principal Investigator: Mohamed Elshaikh, M.D. Molecular Classification of High Grade Endometrial Cancers: Extending TCGA Findings to a High Risk Population (R01CA200864) Subcontract

To update the Henry Ford Health System database for patients with endometrial cancer that includes more than 1,900 women in regards to the different prognostic factors including treatment factors in addition to survival data. Additionally, to identify the patterns of recurrence for those who receive no treatment after surgery compared to those who received radiation treatment chemotherapy for a combination of both. To identify patients who are at higher risk for recurrence based on the known prognostic factors. To conduct data analysis and reporting of the results.

Principal Investigator: Carri Glide-Hurst, Ph.D. Development of Anatomical Patient Models to Facilitate MR-only Treatment Planning (1R01CA204189)

Accurate delineation of targets and organs at risk for radiation therapy planning (RTP) remains a challenge due to the lack of soft tissue contrast in computed tomography (CT), the standard of care imaging for RTP. Radiation Oncology has addressed this limitation by registering magnetic resonance images (MRI) to CT datasets to take advantage of the superior soft tissue contrast afforded by MRI. MRI brings considerable value to RTP by improving delineation accuracy which, in turn, has enabled dose escalation to improve local control while maintaining or reducing normal tissue toxicities. However, the current integration of MRI as an adjunct to CT has significant drawbacks as it requires image registration and contour transfer between datasets. This process introduces systematic geometric uncertainties that persist throughout treatment and may compromise tumor control. Thus, we propose to translate MR-only RTP into clinical use, with the ultimate goal of improving patient outcomes accomplished via improved treatment plan design. MR-only RTP will eliminate redundant CT scans (reducing dose, patient time, and costs), streamline clinical efficiency, entirely circumvent registration uncertainties, and fully exploit the benefits of MRI for high-precision RTP. Yet, MRI is not routinely used alone for RTP, largely due to its known spatial distortions, lack of electron density, and inability to segment the bone needed for online image guidance and electron density mapping for dose calculation. The central hypothesis is that the innovative technologies that our multi- disciplinary academic/industrial (Henry Ford Health System/Philips Healthcare) collaboration develop will yield geometrically accurate patient models built from MRI data across several platforms/field strengths with CT-equivalent densities that can be used in confidence throughout the entire RTP workflow. In Aim 1, we will perform geometric distortion corrections, determine distortion variability with changing anatomy, benchmark the results in a novel modular phantom, and develop an image processing toolkit. In Aim 2, we will fully automate MR image segmentation in the brain and male/female pelvis to yield accurate synthetic CT patient models derived from novel MRI sequences, including provisions for metal implants, and benchmark the results in phantom. In Aim 3, we will conduct end-to-end testing to characterize the uncertainties in the MR-only RTP workflow. We will perform a virtual clinical trial of MR-only RTP for brain and male/female pelvis and compare to the standard of care. Final translation will include developing physician-physicist practice guidelines, end-user validation of all translational steps, and dissemination of image processing tools into the Radiation Oncology community. This research will systematically address the major challenges limiting MR-only RTP and lay the groundwork for multi-institutional clinical trials across MRI platforms. It will support future work related

26 to MR-guided RT, functional MRI for biologically adaptive RT, and focal RT to areas of high tumor burden.

Principal Investigator: Brent Griffith, M.D. A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE) (UH3AR066795) Subcontract

Low back pain, an Institute of Medicine priority condition for comparative effectiveness research, is of major public health importance. It is one of the most common reasons for physician visits and an important cause of functional limitation and disability. Imaging is frequently performed as part of the diagnostic evaluation and is an important contributor to the cost of back pain care, which totaled more than $86 billion in 2005. It is well known that, even without back pain, magnetic resonance (MR) imaging of the lumbar spine frequently reveals findings such as disc desiccation or bulging. Patients and their providers may attribute greater importance to these findings, which are often age-related, than they should, because they do not have an appropriate frame of reference in which to interpret the findings. These incidental findings may initiate a cascade of events leading possibly even to surgery, without improving patient outcomes. We propose a pragmatic, randomized controlled trial (RCT) to determine the effectiveness of inserting epidemiological benchmarks into imaging reports at reducing subsequent tests and treatments. Our rationale is that providing a context for both physicians and patients to better interpret imaging findings may reduce concern about incidental findings and reduce unnecessary further diagnostic tests and treatments. Our intervention is simple, inexpensive and easy to deploy. We propose an efficient, novel, cluster randomized design referred to as a stepped wedgedesign, permitting longitudinal comparisons while controlling for temporal trends. As called for in the Request for Applications, we plan to passively collect primary outcome measures of healthcare utilization both pre- and post-intervention, using robust electronic medical records at our participating sites. We hypothesize that for patients of primary care providers, inserting epidemiological benchmarks in lumbar spine imaging reports will reduce subsequent diagnostic and therapeutic interventions, including MR and CT, opioid prescriptions, spinal injections and surgery. The rationale is that the epidemiologic data may provide a context for both physicians and patients to better interpret imaging findings. The long-term public health significance is high. Not only may this simple, inexpensive intervention substantially reduce unnecessary and expensive care for back pain; thee intervention can easily be generalized to all diagnostic tests, and could become the dominant paradigm for communicating diagnostic information.

Principal Investigator: Jae Ho Kim, M.D. Improving the Radiation Therapeutic Ratio by Inhibiting Proinflammatory Cytokines (R21CA205660)

The goal of the proposal is to determine the potential of a new class of compounds, selective inhibitors of dysregulated proinflammatory cytokines/chemokines, to increase the therapeutic gain for cancer patients receiving radiotherapy for tumors that are known to be radiation resistant (e.g. malignant brain tumors, pancreatic cancer, and lung cancer - stage III/IV). The exploratory proposal builds on our previous discoveries that the lead cytokine/chemokine inhibitor mitigates radiation injury in multiple tissues and the same compound confers an enhancement in radiation tumor growth delay. Two specific aims are planned to confirm the studies in orthotopic tumor models and to elucidate the mechanism of action. In Aim 1, we test the hypothesis that the inhibitor when administered to rats with brain tumors enhances the radiotherapy efficacy and reduces the radiation injury to normal brain. We aim to determine if the therapeutic ratio of a cytokine inhibitor combined with radiation is superior to radiation alone. In Aim 2, we test the hypothesis that the inhibitor suppresses acute proinflammatory cytokines including those produced by activated macrophage in the tumor tissue and reduces neuroinflammation caused by activated microglia in the normal brain following radiation. We aim to elucidate the mechanism of action of a cytokine inhibitor’s effects on the radiation response of tumor and normal brain following single and fractionated radiation. At the completion of these studies we expect that a new paradigm for improving radiation therapy will have been initiated.

27 Part III – Population and Health Sciences

• Center for Health Policy and Health Services Research • Department of Public Health Sciences

Center for Health Policy and Health Services Research

Principal Investigator: Brian Ahmedani, Ph.D. A Targeted Approach to Safer Use of Antipsychotics in Youth (HHSN271201600002C) Subcontract

The National Institute of Mental Health (NIMH) and the National Institutes of Health (NIH) seek to launch a research initiative to address the rising use of antipsychotic medications by youth who do not suffer from a psychotic disorder. Most of the antipsychotic use in communities is for the management of non- psychotic conditions. Antipsychotic use increases the risk of metabolic syndrome and consequently, higher rates of obesity and diabetes. Additionally, the long-term implications of antipsychotic use in youth are unknown. For these reasons, efforts should be made to develop successful alternative treatment approaches that allow a more targeted and appropriate use of antipsychotics with the goal to minimize their usage by youths who do not suffer from a psychotic disorder.

The objective of this study is to successfully identify alternative treatments to the use of antipsychotics in youth (ages 5-17) that are not psychotic, which can manage the emotional and behavior disturbances of these children and adolescents.

The initiative is articulated around the following specific objectives, which will function as sequential phases (i.e., contract options):

A. PHASE 1 - Develop an algorithmic approach to the treatment of non-psychotic behavioral and mood disturbances of youth that minimizes antipsychotic exposure by using non-antipsychotic interventions first and, in case of use of antipsychotics, limiting their use to acute stabilization.

B. PHASE 2 - Pilot-test the algorithm(s) for feasibility, acceptability, preliminary effectiveness.

C. PHASE 3 - Test the effectiveness of the algorithmic approach vs. usual care in practice settings, using a mental health research network, and identify moderators and mediators of treatment outcome.

Principal Investigator: Brian Ahmedani, Ph.D. Treatment Utilization Before Suicide (TUBS) (R01MH103539)

Adult suicide rates in the United States rose by almost 30 percent between 1999 and 2010. These rates have not markedly improved in decades. To date, previous suicide attempts and psychiatric diagnoses are largely the only known clinical risk factors for suicide death. Recent research shows that most individuals who die by suicide make a health care visit in the weeks and months prior to their death. Most of these visits occur in primary care or outpatient medical specialty settings. However, over half of these visits do not include a psychiatric diagnosis.

Thus, there is limited evidence available from health care users in the US general population to inform targeted suicide screening and risk identification efforts in general medical settings. New research is needed to investigate the general medical clinical factors associated with increased suicide risk among individuals without a known risk factor. This research project uses data on more than 4000 individuals who died by suicide and made health care visits to one of eight health care systems across the United States in the year prior to their death. These health systems are

28 members of the Mental Health Research Network and have affiliated health plans. They are able to capture nearly all health care for their members via the Virtual Data Warehouse (VDW). The VDW consists of electronic medical record and insurance claims data organized using standardized data structures and definitions across sites. These data are matched with official regional mortality data. This project includes the following specific aims: 1) identify clinical factors from general medical visits prior to suicide across sites, 2) compare clinical factors to a matched sample of health care users across sites, and 3) investigate indications of psychiatric and other concerns in general medical chart notes prior to suicide. This is the first study with a large enough sample in the US general population to be able to study general medical treatment utilization prior to suicide death. This project will allow the identification of previously unknown factors that increase risk of suicide death, including general medical diagnoses, medications, health care procedures, and types of visits. These results will inform decisions about how to focus suicide prevention efforts in general medical settings.

Principal Investigator: Brian Ahmedani, Ph.D. An Evaluation of the National Zero Suicide Model Across Learning Healthcare Systems (U01MH114087)

Suicide is a major public health concern – it is the 10th leading cause of death and number one cause of injury related death in the United States (US). Due to national concern about this problem, the National Action Alliance for Suicide Prevention and the US Surgeon General published the joint 2012 National Strategy for Suicide Prevention (NSSP). The NSSP outlines a series of Aspirational Goals (AG) with the specific objective to reduce the national suicide rate by 20%. AG 8 and 9 promote healthcare settings as primary targets for suicide prevention. Consistent with this message, Henry Ford Health System’s (HFHS) Perfect Depression Care (PDC) Zero Suicide Initiative was the first US program linked with a substantial decrease in the suicide rate among behavioral health patients after implementation. These findings have motivated national promotion of this model for suicide prevention in health systems. As such, the National ZS Model (NZSM) was developed, based on the HFHS PDC program, but with flexibility to allow adaptation to diverse settings and patient populations. Overall, the NZSM is founded on the realization that suicidal individuals often fall through multiple cracks in a fragmented and sometimes distracted healthcare system, and on the premise that a systematic, comprehensive approach to care is necessary for suicide prevention. The comprehensive approach of the NZSM includes implementation of a series of clinical and quality strategies within the following components: 1) Identification of those at-risk, 2) Engagement and care management; 3) Effective treatment, and 4) Care transition. Despite being a model program promoted internationally for healthcare system quality improvement in suicide prevention, the NZSM has very limited evidence outside of the findings from the HFHS PDC program. The proposed study seeks to conduct a comprehensive process and outcome evaluation of NZSM implementation in real-world clinical settings across 6 large, diverse Mental Health Research Network affiliated Learning Healthcare Systems providing healthcare for over 9 million individuals each year. The project aims are to:1) Collaborate with health system leaders to develop EHR metrics to measure specific quality improvement targets and care processes tailored to local NZSM implementation, 2) Examine the fidelity of the specific NZSM care processes implemented in each system, and 3) Investigate suicide attempt and mortality outcomes within and across NZSM system models. Study data are captured using electronic health records and insurance claims. Given strong national support for NZSM, if it is found to be effective to reduce suicide behavior, this model will have nationwide implications for suicide prevention in healthcare settings.

Principal Investigator: Brian Ahmedani, Ph.D. Mental Health Research Network II (U19MH092201) Subcontract

This application requests five years of funding to sustain and expand the Mental Health Research Network (MHRN), a consortium of 13 research centers affiliated with large integrated health systems. Two new members will join the network, increasing the diversity of health system organization and adding a larger rural population. Established data and informatics infrastructure will be maintained (with

29 reduced levels of funding). New infrastructure development will aim to address the opportunities and challenges described above and to address specific goals described in RFA MH-14-110: * Dissemination of MHRN tools and resources to the broader mental health research community * Facilitating new research collaborations with investigators outside of MHRN member institutions * Improving capacity for ongoing surveillance of mental health treatment patterns and outcomes MHRN will be governed by a steering committee of participating investigators and representatives from NIMH. An Administrative Core will house specific infrastructure activities, including: The Informatics Unit will maintain and expand data infrastructure to support multi-site research. The Organizational Unit will continue work to streamline administrative and regulatory processes. The Outreach and External Collaboration Unit will continue engagement with health system partners and external stakeholders while expanding outreach to external investigators. Four specific research projects are proposed: Reducing cardiovascular risk in adults with SMI using EMR-based clinical decision support - This cluster randomized trial will test an informatics-based intervention to reduce risk factors for cardiovascular disease among people living with severe mental illness. Maximizing biospecimen collection from children with mental health conditions - This pilot study will evaluate strategies for collecting biospecimens from families affected by early-onset mental disorders. Next-generation assessment using mobile devices - This pilot study will evaluate the feasibility, acceptability, and potential utility of direct assessment of behavior and neuropsychological performance (including NIMH RDoC constructs) for prediction or early detection of depression treatment response. Automated outreach for depression treatment dropout - This pilot study will evaluate the feasibility and acceptability of population-based outreach to address early dropout from depression treatment.

Principal Investigator: Jordan Braciszewski, Ph.D. Promoting Smoking Cessation Among Youth Exiting Foster Care (R21CA205190)

Each year, roughly 30,000 youth exit the foster care system due to “aging out” at age 18, losing access to support services while also becoming fully responsible for their own financial, health, employment, and housing needs. Progressing from homes disproportionately high in neglect and maltreatment, these emerging adults face independence with an increased likelihood of heavy tobacco use and, ultimately, the development of tobacco use disorders. Indeed, lifetime tobacco use is nearly ubiquitous among foster youth, while daily use rates are four times that of the general population. Services to curtail such use while young people remain in the foster care system are severely limited, if they are offered at all. Once removed from foster care, these youth have far less access to health services compared to their non-foster care peers. The proposed feasibility study seeks to address these gaps in availability, accessibility, and use of tobacco cessation services for youth aging out of the foster care system.

Computer- and mobile phone-based interventions have the capacity to provide evidence-based treatment content while reducing many of the barriers relevant to tobacco cessation service delivery for foster youth. The proposed study will begin a program of research to synthesize the benefits of these approaches in a way that addresses the needs of a vulnerable population who experience tobacco-related health disparities. More specifically, this study seeks to test an adaptation of an existing substance use intervention (iHeLP: Interactive Healthy Lifestyle Preparation) for smoking cessation among youth aging out of foster care. Rooted in motivational interviewing, the transtheoretical model, and social cognitive theory, iHeLP is a one-time computerized screening and brief intervention (SBI), supplemented by six months of tailored text messaging based on participants’ SBI results and subsequent fluctuations in their readiness to change. The goal of this pilot study is to obtain data on acceptability and feasibility of a novel intervention, as well as examine direction of effects on both overall motivation to change and actual tobacco use. As such, we will conduct a two- arm feasibility trial, testing iHeLP against a contact-control condition. The use of daily text messaging represents a novel method for delivering intervention boosters. Low-intensity, high-frequency interactions are a marked change from traditional interventions and have high potential for extending initial gains. In addition, tailoring of these messages through dynamic, text-based communication with participants is innovative. Given the potential of wide dissemination to multiple at-risk populations at low cost, the proposed study has high potential public health and clinical significance.

30 Principal Investigator: Jordan Braciszewski, Ph.D. Brief Alcohol Intervention and mHealth Booster for Suicidal Adolescents (R34AA025763) Subcontract

Alcohol use puts adolescents with suicide-related thoughts and behaviors at high risk for attempted suicide and suicide death. Typically, adolescents who make a suicide plan or attempt are admitted to an inpatient psychiatric hospital for a brief time period in order to be evaluated. These inpatient units rarely address alcohol use in a comprehensive fashion as the adolescent's suicide risk is the primary focus of treatment. Given the significant role alcohol can play in subsequent suicidal ideation and attempts, greater attention to the assessment and initial treatment of alcohol use in adolescent inpatient psychiatric settings is essential, with a post-discharge follow-up plan playing a critical role in the safety of the suicidal adolescent. The proposed study will develop and test iASIST (integrated Alcohol and Suicide Intervention for Suicidal Teens), a novel adjunctive intervention for alcohol use and alcohol-related suicidal thoughts and behaviors. iASIST involves three components: 1) one 60-90 minute individual intervention with the adolescent in which motivational enhancement techniques are used to explore alcohol use as a risk factor for continued suicide-related thoughts and behaviors, build the adolescent's motivation to reduce or stop their alcohol use, and create a change plan if the adolescent is ready, 2) a subsequent 30 minute family intervention in which the interventionist facilitates a discussion between the adolescent and the parent about the change plan using motivational enhancement techniques to align the parent with the adolescent to strengthen the adolescent's self-efficacy and commitment to the change plan as well as the parent's confidence and ability related to supporting the adolescent in the change plan, and 3) a post-discharge mHealth booster to adolescents focused on strengthening their commitment to the change plan, and to parents focused on their commitment, confidence, and ability related to supporting the adolescent in the change plan. First, we will refine the design of the mHealth booster by obtaining feedback on proposed content, interface, and functionality via in-depth interviews with 8 adolescents and 8 parents who completed the intervention arm of PI O'Brien's current pilot trial of the in-person component of iASIST. Second, we will conduct an open trial of iASIST with 10 adolescents and their parents to test the full adaptation of iASIST (i.e., in-person sessions and mHealth booster) and make subsequent changes for the final study phase. Third, we will conduct a randomized trial with 50 adolescents and their parents to test the feasibility and acceptability of iASIST as well as alcohol- and suicide-related outcomes at 3 months post-discharge. Intervention participants will be compared to adolescents and their parents who will receive an attention-matched comparison condition focused on the role of a healthy lifestyle in mental health that includes a post-discharge mHealth control targeting the maintenance of a healthy lifestyle. The data from this project will inform the preparation of a fully powered, future trial of the intervention.

Principal Investigator: Jordan Braciszewski, Ph.D. iHeLP: Interactive Technology to Prevent Substance Use in Foster Youth (R34DA034822) Subcontract

Each year, roughly 30,000 youth exit the foster care system due to aging out at age 18, losing access to support services while also becoming fully responsible for their own financial, health, employment, and housing needs. Progressing from homes disproportionately high in neglect, maltreatment, and parental substance use, these emerging adults face independence with an increased likelihood of developing substance use disorders. Once removed from foster care, these youth have far less access to health services compared to their non- foster care peers. Moreover, substance use services offered within the foster care system are often difficult to access. The proposed pilot intervention study seeks to address these gaps in availability, accessibility, and use of substance use services for youth aging out of the foster care system. Computer- and mobile phone-based interventions have the capacity to provide evidence-based treatment content while reducing many of the barriers relevant to substance use service delivery for foster youth. The proposed study will begin a program of research to synthesize the benefits of these approaches in a way that addresses the needs of a vulnerable population with many barriers to care. More specifically, this project involves the development and pilot data collection of a preventive intervention (iHeLP) targeting the reduction of problematic substance use among foster youth who are aging out of care. Rooted in motivational interviewing, the

31 transtheoretical model, and social cognitive theory, iHeLP is a one-time computerized screening and brief intervention (SBI), supplemented by six months of tailored text messaging based on participants' SBI results and subsequent fluctuations in their readiness to change. The goal of this pilot study is to obtain preliminary daa on acceptability, feasibility, and initial efficacy. Focus groups will be conducted in which twenty four 17-year old foster youth will provide qualitative feedback on the perceived utility, likelihood of use, and preferences for the content, interface, and functionality of the proposed intervention components. Results will be used to modify the intervention content/format, which then will be delivered to sixteen foster youth in an open trial of iHeLP. Further alterations may result from the qualitative and quantitative results of the open trial. Finally, thirty youth will participate in a pilot randomized controlled trial, testing the efficacy of iHeLP against a contact-control condition. The use of daily text messaging represents a novel method for delivering intervention boosters. Low-intensity, high-frequency interactions are a marked change from traditional interventions and have high potential for extending initial gains. In addition, tailoring of these messages through dynamic, text-based communication with participants is innovative. Given the potential of wide dissemination to multiple at- risk populations at low cost, the proposed study has high potential public health and clinical significance.

Principal Investigator: Keoki Williams, M.D. Combined Transcriptomics and Genomics to Find Asthma Genes in Admixed Populations (R01HL118267)

African American individuals are more likely to develop asthma and are nearly three times as likely to experience serious asthma complications when compared with European American individuals. Genome wide association studies have identified a number of genetic risk markers for asthma, but many of the associations observed in European and European American patients have not replicated in African American individuals. This may be the result of allele frequencies, linkage disequilibria, or disease- related genes which differ by ancestry. Detailed characterization of the transcriptome can aid in the identification of asthma-related genes by circumventing some of the aforementioned problems associated with genotype association alone. Therefore, this proposal seeks to combine transcriptomics and genomics to identify asthma-related genes and the expression quantitative trait loci (eQTL) which appear to regulate these genes. We propose using RNA sequencing (RNA- seq) to characterize the transcriptome of African American individuals with and without asthma. RNA-seq is superior to traditional microarrays at quantifying transcript abundance, but this method has not been widely used in U.S. minority populations to date. The Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-ethnicity (SAPPHIRE) cohort is an ideal group in which combine these analytic approaches. In addition to being one of largest and best characterized asthma cohorts in the U.S., genome wide genotype data and banked whole blood RNA already exist for a large number of SAPPHIRE participants. In Specific Aim 1, we will use RNA-seq to identify expression differences in previously identified asthma- related genes among African American individuals by asthma status. Pre- existing genotype data will then be used to identify eQTL for these differentially expressed, asthma-associated genes. In Specific Aim 2, we will use admixture mapping to identify chromosomal regions where ancestry is associated with asthma. The genes in these regions will be interrogated for differential expression by asthma status. The resulting potentially novel, ancestry-specific asthma genes will also be assessed for eQTL. As a subset of African American SAPPHIRE participants have RNA collected at both their initial evaluation and the time of an asthma exacerbation, in Specific Aim 3 we will assess whether the genes identified in the preceding aims are also associated with asthma exacerbations. Lastly, Specific Aim 4 will attempt to replicate our findings in a separate group of African American participants with and without asthma. In summary, asthma is a complex disease with potentially distinct genetic predictors by ancestry. Persisting inequities in asthma complications by race-ethnicity underscore the need for improved disease biomarkers and therapeutic targets. As a step in this direction, we proffer an integrative approach with greater statistical power to identify asthma- related genes and their regulatory elements.

32 Principal Investigator: Keoki Williams, M.D. Leveraging Electronic Medical Records to Perform Large-Scale Diabetes Pharmacogenomics among Ancestrally Diverse Patient Populations (R01DK113003)

Diabetes mellitus is a modern day scourge, affecting an ever increasing proportion of individuals worldwide, including 26 million Americans currently. Moreover, type-2 diabetes (T2D) disproportionately affects historically disadvantaged U.S. minority groups, as evidenced by the much higher rates of disease and more severe complications among African American individuals. Although there are multiple therapeutic classes of oral medication available for treating T2D, metformin is currently recommended as the first-line therapy. Metformin lowers blood glucose levels by reducing hepatic gluconeogenesis, improving skeletal muscle insulin sensitivity, and limiting intestinal glucose uptake. It has also been shown to be an effective therapy for preventing incident diabetes. Despite being one of the most frequently prescribed drugs worldwide, very little is known about the biologic mechanism(s) through which metformin mediates its effect. This knowledge would be of value therapeutically to better understand and predict treatment response. By extension, even less is known about the activity of metformin among African American individuals, as few studies have included substantial numbers of non- European population groups. This application will help rectify existing knowledge gaps by studying a large and diverse patient population with T2D. Specifically, we will utilize electronic medical record (EMR) data for large-scale diabetes pharmacogenomics. These data have the advantage of being able to account for medication use and drug exposure over time; to provide substantial numbers of individuals for combined and population group specific analyses; and to assess clinical end-points both retrospectively and prospectively. In this application, we propose the following study aims: 1) To assess whether there are differences in metformin treatment response by self-reported race-ethnicity and genetic ancestry; 2) To use novel, gene-based association approaches to identify both shared and population group specific genetic variants influencing metformin's effect on blood glycemia (i.e., HbA1c levels); and 3) To replicate our findings in a separate group of patients and to include additional exploratory analyses to assess whether the identified genetic variants influence diabetes-related microvascular events, macrovascular events, and adverse drug reactions. The knowledge gained through this study will directly address the goals of Health People 2020 – “achieve health equity, eliminate disparities, and improve the health of all groups.”

Department of Public Health Sciences

Principal Investigator: Gwen Alexander, Ph.D. Encouraging Young Adults to Make Effective Nutrition Choices: MENU Gen Y Study (R01HD067314)

The MENU Gen Y Study will focus on developing an age-targeted web-based intervention designed to increase daily intake of fruit and vegetables for young adults (age 21 – 30 “Gen Y”) using features that appeal to and factors relevant to this targeted age group.

Principal Investigator: Gwen Alexander, Ph.D. Breastfeeding Support and Weight Management for Black Women: A Dual Intervention (R21HD085138) Subcontract

Excessive pregnancy-related weight retention is an important determinant of obesity and is more common among African American women. At the same time, breastfeeding, which has been recommended as a strategy to decrease weight retention is lowest among African American women. This racial disparity in breastfeeding may partly explain the disparity in obesity, but even if the two are not causally related, a dual intervention designed to increase breastfeeding duration and decrease postpartum weight retention makes practical sense because both are associated with the same critical postpartum time window. For this study, we will incorporate a postpartum weight management component into an effective breastfeeding support program. This dual intervention will use a

33 combination of in- person, telephone, and interactive web/mobile-based health counseling to provide education and support for breastfeeding difficulties and postpartum weight management. The intervention will be delivered by peer counselors who will be trained to provide support using motivational interviewing techniques with consultation by experts. Additionally, the web-based platform includes tools for tracking diet and physical activity, and is accessible using mobile technology. We have designed the dual intervention to provide encouragement, information, and problem- solving assistance at the appropriate pre or postpartum stage for both breastfeeding support and maternal weight management. The mixed delivery mode has proven effective in other settings and is important to build a trusting relationship while allowing frequent and flexible methods for communicating during this vulnerable time in a new mom's life. The overall goal of this developmental/exploratory R21 proposal is to gather pilot data to effectively refine the intervention so that it can be tested in a larger, longer study using a factorial design in a futur R01 phase. We will recruit, in one large inner-city prenatal care clinic (Henry Ford Health System, Detroit, MI), pregnant African American women (32-36 weeks gestation) who are considering breastfeeding (n=80), randomize them to the intervention or to a usual care group, and follow all participants to 20 weeks postpartum. Our specific aims are to: 1) test feasibility; 2) assess acceptability; and 3) estimate the effect size of the intervention at 20 weeks postpartum relative to the usual care group on (1) breastfeeding duration and (2) postpartum weight retention. This project is significant because the combined intervention is designed to work synergistically on two interrelated, highly prevalent problems that disproportionately disadvantage African American families.

Principal Investigator: Gwen Alexander, Ph.D. Automated Coding of eCoaching Exchanges to Promote Healthier Eating (R21DK108071) Subcontract

Poor eating habits, particularly low fruit and vegetable intake, is a growing, serious public health concern, particularly among young adults age 21-30, referred to as Generation Y (GenY). GenY's poor dietary practices are associated with the onset of obesity and many chronic diseases, such as type 2 diabetes, as well as declines in predicted health status and life expectancy. Thus, there is a need to develop effective interventions to improve GenY's eating habits. MENU GenY is a computer-based intervention to encourage increased fruit and vegetable intake among GenY. A critical component of MENU GenY is personalized eCoaching. eCoaches use email to deliver motivation-enhancing coaching to encourage healthy eating, grounded in the principles of Motivational Interviewing (MI), an evidence-based communication technique to increase intrinsic motivation and self-efficacy for behavior change. The MI model posits that counselor's use of “MI-consistent” communication techniques are responsible for eliciting behavior change through patient “change talk” (i.e., statements about one's own desire, ability, reasons, need for or commitment to behavior change). A growing body of empirical evidence links change talk to behavior change, but research identifying the specific provider behaviors that elicit patient change talk is limited to specific populations (mainly adults who abuse substances and a couple studies of adolescents). Identifying specific communication strategies linked to behavior change and integrating these strategies into communication-based interventions (e.g., brief, motivation-enhancing interventions delivered in a variety of settings or public health initiatives) can increase these interventions' potency. However, a significant barrier to this research is the qualitative methods traditionally used to analyze the communication process which are resource-intensive, requiring an iterative process of human (subjective) interpretation of text. Rapidly developing computational technologies, specifically machine learning combined with classification models, offer a unique opportunity to accelerate this process. Our research group has recently applied machine learning-based data mining models to similar communication data. We automated a simple communication code scheme to characterize patient communication and achieved accuracy comparable to human coders. The goals of this study are to leverage innovative computer science machine learning and classification models to fully automate the communication coding process and link patterns in eCoach-patient communication to increases in fruit and vegetable intake. We propose a secondary analysis of data collected for a NICHD randomized clinical trial (R01 HD067314). The sample is 160 members of GenY drawn from both urban and rural settings (Detroit metropolitan area and rural Pennsylvania) with outcomes measured at baseline and 3 months. Our validated approach will accelerate the pace of outcomes-oriented communication research and identify effective

34 communication strategies linked to healthy eating. These findings will be used to tailor interventions and public health messages and develop automated eCoaching.

Principal Investigator: Andrea Cassidy-Bushrow, Ph.D. Delivery Mode, Environment and the Gut Microbiome: Influence on Childhood Body Size (R01HD082147)

Caesarean section (CS) delivery, which accounts for ~32% of all US births, has been associated with offspring obesity. Little is known about the mechanisms linking CS with obesity risk. The gut microbiome, which varies by mode of delivery, is also associated with childhood obesity. In our established racially and socioeconomically diverse birth cohort (WHEALS; Wayne County Health, Environment, Allergy and Asthma Longitudinal Study), the early-life gut microbiome is associated with body mass index (BMI) category at age 2 years; CS is associated with both a distinct early-life gut microbiome and with increased BMI at age 2 years; and the presence of pets in the home, which increases microbial diversity, reduces the association between CS and BMI. Our data provide evidence for a mediating role of the gut microbiome in the CS-obesity relationship. However, to provide stronger evidence requires additional study. This project builds on extant data in WHEALS and on-going data collection in a subset of these children to examine the role of the gut microbiome in the CS-obesity association. Children will be invited for a research clinic visit for comprehensive body size assessment and blood draw at age 10-12 years. Gut microbiome composition and predicted function will be measured in banked early- life (1 and 6 months of infancy) stool samples and in samples from these children at age 10-12 years using the 16S rRNA and ITS2 biomarker genes and the Illumina MiSeq platform. A metabolomics analysis will be conducted in a subset of these stool samples. Adiposity will be measured as BMI at ages 2 and 10-12 years, BMI trajectory from birth to age 10-12 years, and anthropometric, bioimpedance and inflammatory measures at ages 10-12 years. Combined, we anticipate 630 unique children will have 10-year adiposity measures and at least one early-life microbiome measure (~405 with 1 month and ~381 with 6 month stool samples, which includes ~300 children with paired 1 and 6 month samples). Of these children, 400 will also have gut microbiome measured at age 10-12 years. Our specific aims are to: (1) examine if mode of delivery is associated with childhood adiposity; (2) examine if the gut microbiome is associated with childhood adiposity; and (3) examine whether the gut microbiome mediates relationships between mode of delivery and measures of adiposity. Such a complementary “omics” approach has never been applied to the study of childhood obesity and is likely to provide critical insights into disease development in early- life as well as potential targets amenable for intervention.

Overall Principal Investigator: Christine Cole-Johnson, Ph.D. Project 3, Project 4 Principal Investigator: Ganesa Wegienka, Ph.D. Project 1 Pets and the Infant Microbiome: Effect on Immune Maturation & Atopic Asthma (P01A1089473)

This Program Project Grant (PPG) study seeks an increased understanding of the relationships between dog or cat exposure during infancy and a lower risk of allergic asthma. We believe that this protective association is related to different patterns of microbial stimulation during immune development. Four synergistic Projects will examine our hypothesis that the presence of pets in a home results in a more diverse bacterial community composition (BCC) of the dust in the home which in turn influences the development of the gut BCC of a newborn infant living in the home. A more diverse gut BCC shifts the maturation of the infant's immune system such that later immune responses are less likely to produce IgE antibody responses and allergic asthma. Project 1 examines the relationships between the presence of a dog or cat in a home, the BCC of dust in the home, the BCC of stools of infants living in homes and allergic sensitization at 2 years of age. An innovative, culture-independent microarray (G3 PhyloChip) will be used to characterize the BCCs utilizing previously collected samples from the ongoing WHEALS birth cohort study. Changes in home BCC following introduction of a dog are also examined. Project 2 will recruit a new birth cohort of children either living with or without a dog, measure infant stool BCC, and follow the cohort with detailed studies of immune function until 18 months of age to determine the impact of dog exposure on immune maturation. Project 3 uses mouse models

35 of allergic asthma to further examine the influence of house dust from homes with and without dogs on immune responses that result in lung inflammation. The use of mouse models allows more detailed studies of immune functions from multiple compartments of the body than are possible with human children. Project 4 again utilizes the existing WHEALS birth cohort to examine the relationships between dog or cat exposure during the first year of age, 6-month infant stool BCC, and the presence of allergic asthma at 9 years of age. The Projects are supported by five Cores which each provide essential services to all four Projects. Subcontracts to the University of Michigan, UCSF, and Georgia Regents University, as well as the summaries of the Cores are not described here.

Principal Investigator: Christine Cole-Johnson, Ph.D. Project 3:

Allergic asthma is common in Westernized countries and its prevalence has increased greatly during the last century. Interestingly recent research has shown that exposure to pets during infancy correlates with a lower risk of developing allergy and asthma in later life. In addition, data generated by the PPG investigators have demonstrated that pets can be associated with alterations to the microbiota in house dust. It is well known that soil and dust are ingested by children, and alterations in gut microbiome have been associated with risk for allergic asthma development. In order to further our understanding of the mechanisms that lead to the alterations observed clinically, this project has established and utilized models of pulmonary disease with exposure to dust from homes with dogs versus no pets. Using two different mouse models of allergic asthma (cockroach antigen and ovalbumin), we will study pulmonary immune responses after oral exposure to house dust using samples collected from homes with dogs and without pets. We will test the overall hypothesis that the composition of the dust microbiome from homes with dogs versus no pets differentially alters pulmonary immune responses during allergen exposure by changing the GI microbiota or bacterial community composition (BCC), resulting in systemic changes in antigen presenting cell and bone marrow progenitor cell programming and allergic outcomes. To test this hypothesis, we will specifically focus on clinically relevant mechanisms involved in the ability of pulmonary- derived allergen responses to induce Th2 cytokines, mucus hypersecretion, physiologic changes (AHR), and changes in innate responses locally as well as systemically. Our studies will: 1) establish that exposure of mice to dust from homes with dogs versus no pets will result in differential changes in the GI BCC, 2) demonstrate that the dog dust- altered gut microbiome alters pulmonary allergic responses, 3) establish that the dog dust- induced changes alter dendritic cell responses in the lung, 4) identify that changes in innate responses are a systemic effect by examining bone marrow cell responses, and 5) utilize innovative mouse models to derive the cellular mechanisms of the altered responses. BCC will be measured using the G3 PhyloChip. Thus, these studies, in close collaboration with the other projects in this PPG, will clarify a number of previously unexplored questions and will guide exploration into this novel area of research.

Project 4:

The overall objective of Project 4 is to assess the relationship between exposure to pets, the infant home and gut microbiomes, and allergic asthma at 9 years of age, using an ethnically diverse, population- based general risk birth cohort (the WHEALS cohort). A premise with growing evidence is that lack of exposure to particular patterns of microbial stimuli during early infancy results in a heightened T-helper (Th) 2 response in the maturing immune system, likely due to a suboptimal regulatory capacity, which in turn is associated in childhood with increased immunoglobulin (lg)E, allergy, and clinical allergic conditions such as asthma. Epidemiological studies have revealed that atopic conditions have increased over the latter half of the twentieth century. Humans, in earlier centuries had lifestyles associated with closer direct contact with soil, animals and other humans, suggesting exposure to environments with richer and more diverse microbiological burdens. We hypothesize that evolutionary adaptation to such microbial exposures with respect to immune recognition and regulation may result in untoward consequences when humans are presented with the different, and probably more limited, patterns of microbial exposures found in modern Westernized societies. Our theory is that in many settings, pets, as well as farm animals in close proximity, render the home microbiome, or bacterial community composition (BCC,) to be more similar to early 20th century environments with respect to an increased bacterial richness, diversity and a more even distribution of taxa. This home microbiome impacts

36 directly through effects on the infant gastrointestinal tract BCC the immunogenesis of the infant and subsequently the development of clinically important outcomes such as childhood atopic asthma. Using a new technology (the G3 PhyloChip), capable of cost-effectively identifying, to a great depth, bacteria in environmental and biological samples, our collaborative team has preliminary data suggesting that the presence of dogs and cats is associated with distinct home and infant gut microbiomes characterized by dramatic increases in bacterial diversity, richness and evenness. Using newly measured outcome variables measured by questionnaire and clinical examinations in the WHEALS cohort, in conjunction with PhyloChip analyses of stored infant stool and dust samples, we will test whether distinct patterns of pet exposure, home microbiome and infant gut microbiome are associated with current allergic asthma at age 9 years.

Principal Investigator: Ganesa Wegienka, Ph.D. Project1

The overarching hypothesis of Project 1 is that pet ownership is associated with exposure to a wider diversity of bacteria in house dust, and that these exposures profoundly influence the bacterial community composition (BCC) of the infant gastrointestinal microbiome, maturation of immune responsiveness and subsequently, the development of allergy and allergic asthma. This Project thus proposes two population-based studies and a longitudinal panel study to shed light upon mechanisms that may explain the observed protective effects of exposure to household pets during infancy against development of atopy and high total IgE in infancy. We propose to use an advanced, highly sensitiveand semi-quantitative method for bacterial detection, the G3 PhyloChip. This method offers an unprecedented capacity for detailed, high-resolution profiling of complex microbial communities, detecting in parallel common and uncommon members of assemblages present in house dust and infant stool samples. For Aims 1 and 2, we propose to examine samples already collected and stored form a large, carefully characterized, racially and socio-economically diverse, cohort of children (the WHEALS cohort). In Aim 1 we propose using an innovative case-cohort design to compare samples from infants who became atopic at age 2 years versus samples form a randomly selected sub-cohort (serving as the control group). Using the sub-cohort in Aim 2, we will determine whether, and in what fashion, bacterial community composition of both house dust and infant stool are impacted by pet- keeping and if they are related to each other. The study of bacteria, or bacterial communities, identified as deriving from dog keeping will be enabled by a small prospective panel study proposed as Aim 3, to analyze the changes in microbial community composition of house dust in child-occupied but previously pet-free households into which a dog is introduced. Because the 16S- rRNAPhyloChipprovides information on relative abundance of every bacterial taxon detected, we aim, through statistical analyses, to take advantage of this semi-quantitative data to identify particular bacterial species as critically important in protection against atopy development.

Principal Investigator: Christine Cole-Johnson, Ph.D. Personalizing Care for Obese Patients in an Urban Health System (R24HS022417)

Today, patients and providers are presented with more health care options than ever before. There is considerable doubt and lack of understanding of science not only among patients, but also among physicians. Without systematic, evidence-based guidance for the appropriate and efficient use of the multitude of treatment options, as well as the consideration of patient preferences, the rapid growth and complexity of treatments will only add to the existing confusion about which option is best for each individual patient. The objective of the proposed Patient-Centered Outcome Research Center (PCORC) is to fully leverage and further develop the research infrastructure and clinical assets of Henry Ford Health System (HFHS) in order to conduct Patient-Centered Outcomes Research (PCOR). The PCOR evidence will guide care in order to achieve patient-desired outcomes in our urban and suburban patient populations located throughout Metropolitan Detroit. The Center will be organized into four different Cores (Patient Engagement Core, Study Design and Analysis/Measurement Core, Patient Data Network Core, and Implementation/Dissemination Core) with different functions. The Center currently has three PCOR projects proposed that are focused on our selected theme of caring for the obese patient. The HFHS PCORC will maximize programmatic and scientific efficiency within our health care system setting, promote shared use of resources and standardization of processes and

37 procedures, promote training in PCOR/Comparative Effectiveness Research (CER) methods, and facilitate rapid dissemination of research findings to the medical community and translation of those results into our system's clinical practice.

The Center will build on existing research capabilities by developing expertise in novel PCOR methods through didactic course work, educational sessions at national meetings and content-specific educational seminars. These educational experiences will allow the Center staff to learn how to develop and conduct innovative PCOR studies that will provide evidence for the many pressing issues in patient care. The Center will demonstrate its proficiency through the conduct of the proposed projects.

The proposed PCORC is relevant to public health because it provide research infrastructure and methods for the design and conduct of patient-centered outcome research (PCOR) projects in patients within our health care system. The results of those projects will provide evidence-based and patient-centered guidelines available to physicians in their offices, on a real-lime basis in order to ultimately provide care that places each individual patient and his/her preferences at the center of decision-making.

Principal Investigator: Christine Cole-Johnson, Ph.D. Trans-America Consortium of the Health Care Systems Research Network for the Precision Medicine Initiative Cohort Program (1OT2OD024610) Aim 1: Using our existing network of Patient Advisors and experts, finalize the TACH governance and establish an oversight structure to a) continuously conduct rapid assessments of recruitment, enrollment and retention goals, and b) rapidly deploy and test interventions and apply modifications as necessary, for the following processes: 1. Engagement of all recruitment site facilities and staff in our initial designated catchment areas; 2. Outreach and enrollment of research-empowered Patient Partners; 3. Collection and transfer of Patient Partners’ consent, survey and physical exam data, and biospecimens; 4. Periodic compilation and transfer of Patient Partners’ EHR data to the PMI-CP Coordinating Center and return of data to Patient Partners. Aim 2: Fully enroll within a 12 month period 10,000 Patient Partners (defined as completion of informed consent, baseline exam and survey, biospecimen collection, and initial and recurring extraction of their EHR data). Submit specimens daily to the PMI-CP Biobank and EHR data as one pipeline to the PMI-CP Data and Research Support Center (DRSC) on the schedule determined by the PMI-CP Steering Committee (PMI-CP SC). Return individual and comparative data to Patient Partners as specified.

Principal Investigator: Christine Cole-Johnson, Ph.D. Children’s Respiratory and Environmental Workgroup (CREW) (UG3OD023282)

The grant is part of $157 million in awards announced yesterday by the NIH that launches a seven- year initiative called Environmental Influences on Child Health Outcomes (ECHO). The ECHO program will investigate how exposure to a range of environmental factors in early development – from conception through early childhood – influences the health of children and adolescents.

Study Highlights The CREW consortium will be tasked with identifying specific asthma subtypes and overcome shortcomings of individual cohorts by: Providing a large and diverse national data set of nearly 9,000 births and long-term follow-up for 6,000-7,000 children and young adults. Harmonizing data related to asthma clinical indicators and early-life environmental exposures. Developing standardized measures for prospective data collection across CREW cohorts and other ECHO studies. Conducting targeted enrollment of additional subjects into existing cohorts.

Experiences during sensitive developmental windows, including around the time of conception, later in pregnancy, and during infancy and early childhood, can have long-lasting effects on the health of children. These experiences encompass a broad range of exposures, from air pollution and chemicals in our neighborhoods, to societal factors such as stress, to individual behaviors like sleep and diet.

38 They may act through any number of biological processes, for example changes in the expression of genes or development of the immune system.

Principal Investigator: Christine Cole-Johnson, Ph.D. Center for Urban Responses to Environmental Stressors (P30ES020957) Subcontract

Situated in the heart of Detroit, the environmental health sciences “identity” of the Center for Urban Responses to Environmental Stressors (CURES) is to understand the health impacts of environmental exposures to complex chemical and non-chemical contaminants in Detroit's urban landscape. Our strategic vision is to provide leadership to identify, evaluate, and mitigate environmental health concerns in close collaboration with the community and environmental policy makers. CURES has assembled a unique interdisciplinary team of established and new environmental health scientists and community partners to address major environmental health challenges facing Detroit's racially and ethnically diverse population. We hypothesize that “modern- era” diseases (e.g., cardiovascular disease, cancer, diabetes) that compromise the quality of life of residents living in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which re-program key cellular networks to favor pathogenesis. CURES advances the NIEHS 2012-2017 Strategic Plan by nurturing strong bonds with Detroit's urban community, applying translational and interdisciplinary team-research approaches to solve complex environmental health problems, and by seeking the sources of environmental health disparities. CURES is making an impact in our region. Our researchers and community partners responded rapidly and coordinately to a serious emerging health crisis in our immediate vicinity; the 2015-2016 lead watershed contamination disaster in Flint, Michigan. To create a gateway to a healthy Detroit, CURES' short-term goals are to: 1) strengthen existing partnerships and continue to develop new ones between CURES and the Detroit community; 2) in collaboration with them, identify the chief environmental health threats to Detroit's vulnerable populations; 3) conduct highly integrated mechanistic, epidemiological, and community-engaged research that addresses the impact of urban environmental exposures on human health; 4) build the capacity of CURES to accomplish its research goals by providing facility cores that are optimized to meet the needs of its members and seed funds to support pilot projects to explore the feasibility of new areas of study; and 5) enhance the impact of CURES on the field of environmental health science by providing mentoring to new and established investigators that supports their professional goals and prepares them for leadership roles in environmental health research. Our long-term goals are to 1) enhance our community partners' efforts to increase community awareness and facilitate programs for a healthier community and 2) develop appropriate strategies, based on CURES research, to inform policy so as to mitigate the risks associated with urban environmental exposures. We believe that CURES is optimally positioned on "the ground floor" of innovative team science opportunities that have the greatest promise to realize the early detection, prevention, and eventual eradication of urban environmental disease in our lifetime.

Principal Investigator: George Divine, Ph.D. Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance: Randomized Controlled Trial for Treatment of Extensively Drug-Resistant Gram-Negative Bacilli (Option 5) (HHHSN272201600049C) Subcontract The Gram-negative bacilli organisms Acinetobacter baumannii, Klebsiella spp., Escherichia coli, Enterbactor spp. and Pseudomonas aeruginosa have become a frequent cause of bloodstream infection and pneumonia in the hospital and other healthcare settings. Among these pathogens, antimicrobial resistance has emerged to many classes of antimicrobial agents. Most concerning, has been the emergence of resistance to group 2 carbapenems (such as imipenem). In several regions of the world, including Southeastern Michigan, strains of extensively-drug resistant Gram-negative bacilli (XDR-GNB) that exhibit resistance to most, and in some cases all types of available antimicrobial agents, including group 2 carbapenems, have emerged and disseminated. Treatment options for XDR-GNB typically include Colistimethate sodium (referred to as colistin in this study), used alone (monotherapy) or in combination with other agents. Unfortunately, resistance to colistin has begun to emerge in some strains

39 of XDR-GNB, which is a truly concerning development, since colistin is one of the last remaining treatment options for XDR-GNB. No prospective, randomized controlled trials have been conducted to evaluate the clinical efficacy of colistin monotherapy versus colistin-containing combination therapy or the impact of these therapeutic modalities on the emergence of colistin resistance among XDR-GNB. We plan to conduct a double-blind randomized controlled trial including patients with pneumonia and bloodstream infection due to XDR-GNB. After enrollment, subjects will be randomized to receive 14 days of either colistin monotherapy or colistin plus meropenem. In the Detroit metro area, infections due to XDR-GNB have developed into a regional challenge and common problem. We have assembled a multi-disciplinary team that includes Infectious Diseases researchers, clinicians, infectious diseases pharmacists, microbiologists, epidemiologists and statistical experts to address critically important questions and challenges regarding the management of bloodstream infection and pneumonia due to XDR-GNB. Specifically, we hypothesize that the combination of colistin and imipenem will provide superior efficacy in the treatment of XDR-GNB pneumonia and bloodstream infection and will prevent the emergence of decreased susceptibility to colistin among XDR-GNB strains. We also aim to analyze tools that could be used in "real time" to aid clinicians treating patients with infection due to XDR-GNB. For example, we aim to analyze the association between the presence of in vitro synergy of the colistin and carbapenem (imipenem or meropenem) combination (as determined by E-test) and clinical outcomes; and the association between colistin plasma levels and clinical outcomes and the development of nephrotoxicity.

Principal Investigator: George Divine, Ph.D. Pulsed UV Xenon Disinfection to Reduce Multidrug Resistant Hospital Infections (R01HS024709) Subcontract

The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control) with crossover at 12 months, following a 6-month washout period. Outcome measures include the rates of HAIs, as well as the recurrence of genetically identical clinical strains of HAIs among patients on study units. The study will be conducted in 2 hospitals covering 16 total hospital units at Detroit Medical Center. Our central hypothesis is that the addition of PX-UV to standard terminal cleaning will be associated with a significant reduction in the rate of HAIs, as well as a reduction in the recovery of genetically identical strains of MDROs. The impact of PX-UV disinfection on rates of HAIs on study units will be determined by comparing rates of HAIs on a) study units where PX-UV is added to standard terminal cleaning practices to b) units where a sham UV disinfection system is added to standard terminal cleaning; and by comparing rates of HAIs on the same medical ward during each of two 12-month phases of a crossover study (one phase when a PX-UV device is added and one when a sham device is added to standard terminal cleaning). The long-term goal of this project is to establish the efficacy of terminal cleaning plus PX-UV in reducing rates of HAIs due to the following multi-drug resistant organisms (MDROs): C. difficile, vancomycin- resistant enterococci (VRE), Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamases (ESBLs), methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. At the conclusion of the proposed project, novel data will be generated from this rigorously controlled study regarding the effectiveness of PX-UV in reducing HAIs in a representative, real-world healthcare setting.

Principal Investigator: Michael Flynn, Ph.D. CT Dose Collaboratory (R01CA181191) Subcontract

The objective is to conduct a prospective, sham controlled, double-blinded, interventional crossover trial to compare standard terminal cleaning plus PX-UV (intervention) with standard terminal cleaning plus sham PX-UV (control) with crossover at 12 months, following a 6-month washout period. Outcome

40 measures include the rates of HAIs, as well as the recurrence of genetically identical clinical strains of HAIs among patients on study units. The study will be conducted in 2 hospitals covering 16 total hospital units at Detroit Medical Center. Our central hypothesis is that the addition of PX-UV to standard terminal cleaning will be associated with a significant reduction in the rate of HAIs, as well as a reduction in the recovery of genetically identical strains of MDROs. The impact of PX-UV disinfection on rates of HAIs on study units will be determined by comparing rates of HAIs on a) study units where PX-UV is added to standard terminal cleaning practices to b) units where a sham UV disinfection system is added to standard terminal cleaning; and by comparing rates of HAIs on the same medical ward during each of two 12-month phases of a crossover study (one phase when a PX-UV device is added and one when a sham device is added to standard terminal cleaning). The long-term goal of this project is to establish the efficacy of terminal cleaning plus PX-UV in reducing rates of HAIs due to the following multi-drug resistant organisms (MDROs): C. difficile, vancomycin- resistant enterococci (VRE), Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamases (ESBLs), methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii. At the conclusion of the proposed project, novel data will be generated from this rigorously controlled study regarding the effectiveness of PX-UV in reducing HAIs in a representative, real-world healthcare setting. Principal Investigator: Lois Lamerato, Ph.D. Central Data Collection Center (CDCC) (HSN26100001) Subcontract

The PLCO Central Data Coordinating Center (CDCC) is an extension of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. To reduce costs, the extension has one data collection site under the direction of the National Cancer Institute (NCI) rather than the original ten PLCO Screening Centers. PLCO participants were invited to be transferred to the CDCC for continued, active follow up. Other participants agreed to be passively followed at the PLCO sites through tumor registry searches. PLCO was designed to determine if screening for prostate, lung, colorectal and ovarian cancer can reduce mortality from these cancers. In addition, PLCO has a collection of pre- and post-diagnostic biological samples stored in the PLCO Biorepository, and epidemiological data from questionnaires. These data are a valuable resource for cutting-edge molecular epidemiologic research. The study was extended in this streamlined fashion to increase the value of the resource. The study will continue to update key exposure data by collecting additional risk and lifestyle information, including medication use and medical conditions that are common in older adults. Also, the CDCC will collect additional clinical data and tumor tissue of selected cancers, such as that of the colon and ovaries. This extension of the PLCO Cancer Screening Trial enhances the value of the PLCO resources through the substantial increase in the number of incident cancers accrued within the Trial, strengthens the Trial's ability to clarify further the long-term effects of screening on cancer mortality, and provides a final opportunity to collect additional exposure data and expand the existing tumor pathological resource within the PLCO. Principal Investigator: Lois Lamerato, Ph.D. US Hospital Vaccine Effectiveness (VE) Network (U01P000974) Subcontract US Influenza Vaccine Effectiveness Network (U01IP001034) Subcontract

Prevention of hospitalization has long been viewed as a major health benefit of the use of influenza vaccine. This was, in large part, the rationale for the initial vaccination programs targeting the elderly and those with underlying health conditions. However, in the last decade, questions have been raised about the value of such programs. Modern study designs to assess vaccine effectiveness (VE) have required laboratory confirmation of influenza infection, as well as documentation of vaccine receipt and the use of a test-negative design to control for differences in healthcare-seeking behavior between vaccinated and unvaccinated patients. There is a need for current estimates of VE in preventing influenza-associated hospitalization using these methods. We propose estimation of influenza vaccine effectiveness in preventing influenza hospitalization in two health systems in Michigan, where we have been conducting annual assessments of VE in various populations since 2008. We will conduct surveillance at two hospitals, and will enroll adult in-patients with acute respiratory infection. Vaccination status will be

41 reported and documented, and considered with laboratory-confirmed influenza outcomes to estimate vaccine effectiveness for prevention of hospitalization. Analyses will use a test- negative design; those testing positive for influenza ar cases, those testing negative are controls. Modifiers and confounders of vaccine effectiveness such as age, health status, high-risk health conditions, functional status, frailty, education, tim from illness onset to specimen collection, calendar time, and propensity for vaccination will be assessed. In addition to our proposed influenza surveillance and VE assessment, we propose an estimation of the incidence of hospitalization in adults due to respiratory syncytial virus (RSV and other respiratory viruses. This will allow for the evaluation of bias in influenza VE assessment due to interaction between influenza vaccination, infection, and non-influenza respiratory viruses, and will establish a platform for the future evaluation of RSV vaccines. We will accomplish these additional objectives by expanding our surveillance to months before and after the typical influenza season and evaluating specimens by molecular methods for RSV and other respiratory viruses.

Principal Investigator: Albert Levin, Ph.D. Comprehensive Analysis of Gene-Environment Interaction in Sarcoidosis (R21HL129023)

Sarcoidosis is a multi-organ granulomatous, inflammatory disease of uncertain etiology, with 90% of cases presenting pulmonary involvement. Despite convincing evidence that sarcoidosis likely arises when a genetically-susceptible host is exposed to a causative environmental agent, studies of environmental agents and disease risk suggest that there is more than one single environmental trigger. Further, there have been few gene-environment interaction (GxE) studies of disease etiology published to date; those few have focused on the class II genes within the Human Leukocyte Antigen (HLA) region, the most studied and validated region associated with sarcoidosis risk. In the United States, African Americans are at highest risk for sarcoidosis; the adjusted annual incidence among African Americans is roughly three times that of European Americans (35.5/100,000 versus 10.9/100,000). Among African Americans, the disease is also more likely to be chronic and severe. We recently performed the first gene-environment-wide interaction study (GEWIS) of insecticide exposure and sarcoidosis risk in the Ancestry Mapping of Sarcoidosis Study (AMASS), a large study of sarcoidosis in African Americans. Using our recently- developed methodology, we identified a genome-wide significant GxE association in the FUT9 gene. To build on this effort, the current proposal will focus on the family-based portion of AMASS (503 families, including 818 sarcoidosis cases and 632 healthy family members), which has a rich resource of both environmental exposure and genetic (genome-wide genotyping, targeted/full exome sequencing, and imputed HLA Class I and II genes) data available. First, we propose to identify environmental exposures associated with sarcoidosis risk (Aim 1). Where existing sarcoidosis studies have been limited to investigating environmental exposures in isolation, we will move beyond this trend by using latent-class analysis (LCA) to identify patterns across multiple environmental exposures. Associated environmental exposures (individual and/or LCA- identified multi-exposure groups) will be evaluated for GxE effects (Aim 2). Current family-based GEWIS have focused on the exhaustive strategy of testing all genetic variants. To attempt to improve power, we will extend a two-step strategy to our study of related and admixed individuals and compare both exhaustive and two-step GEWIS strategies via simulation. The strategy with the highest power that also controls the type-1 error rate will be selected for GxE testing for the environmental factors from Aim 1. In summary, we propose multiple innovations to the fields of both GxE analysis and sarcoidosis research that increase the chance for better understanding of the etiology of this debilitating disease.

Principal Investigator: Benjamin Rybicki, Ph.D. A Nested Case-Control Study of Prostate Carcinogenesis (R01ES011126)

Chronic inflammation, which is caused by infectious agents or exposure to environmental factors such as heterocyclic amines, is believed to play a role in up 20% of adult cancers. In prostate, genetic, molecular pathology, and toxicology data suggest that inflammation- related processes are involved in cancer development, but these data conflict with results of epidemiological studies that show an inverse correlation between inflammation and prostate cancer risk. This may be due to bias in the

42 factors that lead men to undergo prostate biopsy, as well as complexity of the inflammatory phenotype itself. Our proposed study will address this paradox by dissecting inflammation at the cellular, molecular, and clinical level. The Henry Ford Health System biorepository contains benign prostate tissue specimens collected from over 9,000 men over the past 20 years, including over 1,000 men who subsequently developed prostate cancer. Using this unique cohort with its annotated clinical baseline and follow-up data, we will conduct a nested case-control study of 700 prostate cancer case- control pairs. Characterizing inflammatory markers in these pre-disease specimens will allow us to determine the nature of tumor- suppressive vs. tumor-supportive inflammatory signatures. We will also measure telomere length in the same benign prostate tissue specimens in which we characterize inflammation to assign a malignancy-potential signature to each specimen. Approximately 1 million prostate biopsies are performed annually in the US, two thirds of which reveal benign condition. Our cohort includes a large group of patients who are at high risk of prostate cancer despite a negative biopsy. An in-depth characterization of inflammation in the benign prostate, before histologic signs of malignancy become apparent, will provide insight into the type of inflammatory milieu associated with eventual tumor development as well as cancer progression and recurrence. A better understanding of the clinical implications of chronic inflammation of the prostate so often observed in older men can have significant impact upon millions of men where currently a negative biopsy offers little reassurance in terms of prostate cancer outcomes.

Principal Investigator: Ganesa Wegienka, Ph.D. Epidemiology of Allergic Disease Endotypes (R01AI110450)

Pediatric allergy and asthma are a costly public health burden, but so far substantial research efforts have yielded no prevention strategies. A likely reason is that despite longstanding recognition by the medical community that the term ‘asthma’ refers to a collection of diseases, researchers have historically treated the syndrome as a single disease entity. Epidemiologically, the collapse of different phenotypes (observed disease patterns) and endotypes (phenotypes further delineated by pathophysiological processes), into a single category corrupts associations between risk factors and diseases. Thus, progress in allergic disease research has been hampered. Prior attempts have been made to identify such phenotypes and endotypes, but a combination of incomplete data and oversimplified statistical methods have limited progress. We propose to apply sophisticated latent class analyses in a large general risk cohort combined with immunological markers to finely discriminate asthma and allergy disease phenotypes and endotypes and then use this information to conduct risk factor analyses. Using this approach in our WHEALS birth cohort, we have already characterized four classes at age 2 years: 1) Low to No Sensitization; 2) Highly Sensitized; 3) Milk and Egg Dominated Sensitization; and 4) Peanut and/or Inhalant allergen – No Milk Sensitization. Total IgE levels varied between the groups, as did the rates of eczema and doctor diagnosis of asthma (at age 4 years). The Highly Sensitized had the greatest rates, the Low to No Sensitization had the lowest rates, and the other two classes had rates intermediate between the Low and High Sensitization groups. These data suggest the use of latent classes, rather than the use of the “traditional” definition of atopy (any allergen-specific IgE (sIgE) _0.35 IU/mL), more specifically identifies those on a trajectory for allergic disease, yielding advancement in both allergic disease research and clinical care. Using the predominantly (62%) African American birth cohort WHEALS, we will: Aim 1) Determine which early life allergic disease phenotypes identified at age 2 years are associated with lung function (spirometry and methacholine challenge) at age 10 years; Aim 2) a) Identify the allergic disease endotypes for 10 year old children based on annual report of wheeze; lung function, eNO, obesity, cytokines, and white cell counts and extensive immunophenotyping [assessment of cellular markers to identify and quantify activation of regulatory T cells (Tregs), basophils and dendritic cells (DCs)] at age 10 years; and total IgE and sensitization (sIgE and skin prick tests) at ages 2 and 10 years; and, b) Estimate associations between early life risk factors (e.g., delivery type, pet exposure, etc.) and the identified Aim 2a endotypes; and, 3) Compare and contrast the risk factor associations with the endotypes in Aim 2 to the risk factor associations determined using “traditional” definitions of atopy and asthma (doctor diagnosis and medication use and/or symptoms in the last year). Analyses will be performed for all 900 WHEALS cohort children and separately for Black children and White children to assess racial differences.

43 Principal Investigator: Ganesa Wegienka, Ph.D. Environmental Risk Factors for Uterine Fibroids: A Prospective Ultrasound Study (R01ES028235) Study of Environment, Lifestyle, and Fibroids (SELF) (HHSN273201600003I) Subcontract

Uterine leiomyomata (UL), or fibroids, are the most common neoplasms of the uterus and are a major source of gynecologic morbidity. In the United States (U.S.), the lifetime risk of symptomatic UL is approximately 25-30%. UL are the leading indication for hysterectomy, and UL-related costs exceed $34.4 billion annually. Black women are disproportionately affected by UL, with a 3-fold greater risk of diagnosis, earlier age at diagnosis and surgery, and more symptomatic tumors on average than white women. Despite the large public health burden of UL, little is known about its natural history or pathogenesis. Animal data and cross-sectional human studies have provided compelling preliminary evidence of a role for vitamin D in UL development and growth. Exposure to heavy metals such as lead, mercury, and cadmium is widespread, with reproductive-aged women, African Americans, and those of lower socioeconomic status having higher exposure levels than other groups. Funded by the National Institute of Environmental Health Sciences (NIEHS), the Study of Environment, Lifestyle and Fibroids (SELF) is a multi-year prospective cohort study of UL determinants in black women from the Detroit area. In 2011-2012, SELF enrolled 1,696 black women aged 23-34 years who had never been diagnosed with UL. At baseline and every 20 months for a total of 5 years (4 total clinic visits), SELF participants complete interviews, have blood collected for biological measurements, and undergo transvaginal ultrasounds for precise identification and mapping of UL at each visit facilitating accurate determination of UL development and growth (cohort retention >85%). The final planned clinic visits are underway. In this application, we propose to extend follow-up of SELF for an additional five years. One more clinic visit with transvaginal ultrasound, biospecimen collection and detailed exposure assessments via interview will be conducted to achieve the following specific aims: 1) Describe the natural history of UL initiation and growth; calculate age-specific UL incidence; and evaluate changes in tumor characteristics (size, number, and location) over a 10-year period; 2) Assess whether vitamin D status influences UL incidence and growth over a 10-year period; and 3) Evaluate the influence of selected environmental toxicants on UL incidence and growth. Specifically, we will examine the influence of active and passive cigarette smoking on UL incidence and growth; assess exposure to a panel of 13 metals and metalloids (and their mixtures) measured in whole blood and UL incidence and growth over a 10-year period; and determine whether vitamin D status modifies the associations between environmental toxicants and UL incidence. With its prospective design, population of young black women, serial ultrasounds, repeated collection of data on exposures and covariates, and careful analysis of chemical mixtures, SELF is ideal for identifying environmental risk factors for UL. Using methods that overcome the limitations of prior studies, this will be the most definitive study of modifiable environmental risk factors of UL and is likely to have high impact on science, clinical care, and public health policy.

Principal Investigator: Ganesa Wegienka, Ph.D. Comparing Options for Management: Patient-Centered Results in Uterine Fibroids (COMPARE- UF) (P50HS023418) Subcontract

The broad, long-term objective of this project is to enable patients with uterine fibroids (UF) to make informed decisions about management options based on the highest possible quality evidence. To help achieve this objective, we propose a multi-center registry of a geographically, racially, ethnically, and clinically diverse group of women who have received medical or surgical treatment for UF, Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF), designed to address the following specific aims: AIM 1) Develop the infrastructure necessary to implement large- scale observational comparative effectiveness research (CER) studies of management options for women with UF, including (a) a governance structure, policies, and procedures conducive to collaborative research involving patients, clinicians, methodologists, and other stakeholders, (b) an experienced Research and Data Coordinating Center, and (c) nine geographically diverse Clinical Centers (CCs) representing a broad range of patients and providers. AIM 2) Use this infrastructure to implement 3 projects addressing high-priority evidence gaps related to the effect of different management strategies on patient-centered outcomes. These include PROJECT 1: Comparing management options for symptom relief PROJECT 2: Comparing management options for preserving

44 reproductive function PROJECT 3: Comparing effectiveness in different subpopulations. AIM 3) Evaluate innovative methods for the design, conduct, and analysis of observational comparative effectiveness research in this population. AIM 4) Translate research results into improved patient care, through both traditional peer-reviewed publications and collaborations with stakeholders to integrate the research findings into evidence-based patient decision making tools, clinical practice guidelines, and quality measures.

Principal Investigator: Ganesa Wegienka, Ph.D. Study of Ovarian Aging and Reserve in Young Women (SOAR) (R01HD088638) Subcontract

The average age for a woman to have her first child has been increasing for the last three decades in the United States, making our understanding of ovarian aging and its negative effect on the ovarian reserve, a measure of the capacity of the ovary to produce eggs capable of fertilization. Yet, we know very little about other factors in reproductive-age women that might affect the ovarian reserve, beyond aging itself. This proposal, titled Study of Ovarian Aging and Reserve in Young Women (SOAR), seeks to address the significant gap in our knowledge of factors, particularly modifiable factors, that affect ovarian reserve and might accelerate its decrease in young women. To achieve this goal, we will leverage the ongoing NIEHS Study of Environment, Lifestyle and Fibroids (SELF), which is following a cohort of 1,696 African- American women between the ages of 23-34 years over a five-year period. In this group of young women, we will assess changes in the ovarian reserve by tracking three different measures of the ovarian reserve: anti- Mullerian hormone (AMH), early follicular phase follicle- stimulating hormone (FSH), and antral follicle count (AFC). In addition to collecting survey data, we will also perform oral glucose tolerance testing (OGTT) and anthropometric and bioelectrical impedance analysis (BIA) measurements to more precisely determine the roles of glucose metabolism and obesity on the ovarian reserve. The results of our study will be clinically significant as we currently have limited longitudinal data for counseling women on risk factors for decreased ovarian reserve. Our study design is innovative in that we will use overlapping measures of the ovarian reserve and group-based trajectory modeling to determine correlates associated with decreased ovarian reserve. Specifically, we will determine the demographic, health-behavior, reproductive, and environmental factors associated with decreased AMH (as a measure of the ovarian reserve) over time (Aim 1), determine the association between various measures of obesity and decreased ovarian reserve (Aim 2), and determine the association between glucose dysregulation and decreased ovarian reserve (Aim 3). The proposed prospective longitudinal cohort study will determine the natural history of and factors associated with the change in ovarian reserve over time. Further, it will add to the extremely limited data by generating the largest set of longitudinal data on AMH and ovarian reserve in the United States to date, which will benefit all women.

45 HENRY FORD HEALTH SYSTEM PUBLICATION LIST FROM SLADEN LIBRARY: JAN – DEC 2017 (Only ePubs published in print journal or online journal in 2017 included)

ADMINISTRATION

Smith KL, Fedel P, and Heitman J. Incapacitated Surrogates: A New and Increasing Dilemma in Hospital Care J Clin Ethics 2017; 28(4):279-289. PMID: 29257763. Article Request Form

ANESTHESIOLOGY

Cata JP, Guerra CE, Chang GJ, Gottumukkala V, and Joshi GP. Non-steroidal anti-inflammatory drugs in the oncological surgical population: beneficial or harmful? A systematic review of the literature Br J Anaesth 2017; 119(4):750-764. PMID: 29121285. Full Text

Gandam Venkata H, Upadhyay AY, and Talari G. Pain as a predictor of disability in elderly population Anesthesiology 2017; 127(6):1038-1039. PMID: 29135554. Full Text

Meselhy E, Akopyan R, and Onyewuche V. Failed neonatal intubation rescued with a tongue stitch and Glidescope- assisted fiberoptic technique J Clin Anesth 2017; 44:57-58. PMID: 29121549. Full Text

BEHAVIORAL HEALTH SERVICES/PSYCHIATRY

Ahmedani BK, Peterson EL, Hu Y, Rossom RC, Lynch F, Lu CY, Waitzfelder BE, Owen-Smith AA, Hubley S, Prabhakar D, Williams LK, Zeld N, Mutter E, Beck A, Tolsma D, and Simon GE. Major physical health conditions and risk of suicide Am J Prev Med 2017;PMID: 28619532. Full Text

Akinyemi E, Watkins DC, Kavanagh J, Johnson-Lawrence V, Lynn S, and Kales HC. A qualitative comparison of DSM depression criteria to language used by older church-going African-Americans Aging Ment Health 2017:1-7. PMID: 28612654. Article Request Form

Bryce R, Guajardo C, Ilarraza D, Milgrom N, Pike D, Savoie K, Valbuena F, and Miller-Matero LR. Participation in a farmers' market fruit and vegetable prescription program at a federally qualified health center improves hemoglobin A1C in low income uncontrolled diabetics Prev Med Rep 2017; 7:176-179. PMID: 28702315. Full Text

Ghaziuddin N, Hendriks M, Patel P, Wachtel LE, and Dhossche DM. Neuroleptic malignant syndrome/malignant catatonia in child psychiatry: Literature review and a case series J Child Adolesc Psychopharmacol 2017;PMID: 28398818. Article Request Form

Jasinski MJ, Lumley MA, Soman S, Yee J, and Ketterer MW. Indicators of cognitive impairment from a medical record review: Correlations with early (30-d) readmissions among hospitalized patients in a nephrology unit Psychosomatics 2017; 58(2):173-179. PMID: 28104336. Full Text

Jesse MT, Abouljoud M, Eshelman A, De Reyck C, and Lerut J. Professional interpersonal dynamics and burnout in european transplant surgeons Clin Transplant 2017;PMID: 28185307. Full text

Ketterer MW, Chawa M, and Paone G. Prospective correlates of early (30 day) readmissions on a cardiothoracic surgery service Psychol Health Med 2017:1-8. PMID: 28161983. Article request form

MacLean L, and Prabhakar D. Why physicians die by suicide: Lessons learned from their families and others who cared J Am Acad Child Adolesc Psychiatry 2017; 56(10):898-899. PMID: Not assigned - Book Review.

Prabhakar D, and Akinyemi E. Concussion J Am Acad Child Adolesc Psychiatry 2017; 56(2):176-177. PMID: Not assigned. Full text

Prabhakar D. Ordinarily well: The case for antidepressants J Psychiatr Pract 2017; 23(5):386-387. PMID: Not assigned - Book Review.

46 Singh G, and Akinyemi E. Managing manic delirium in bipolar disorder with features of mania, catatonia, and neuroleptic malignant syndrome Prim Care Companion CNS Disord 2017; 19(6)PMID: 29272572. Article Request Form

Neuropsychology

Maiman M, Salinas CM, Gindlesperger MF, Westerveld M, Vasserman M, and MacAllister WS. Utility of the behavior rating inventory of executive function - preschool version (brief-p) in young children with epilepsy Child Neuropsychol 2017:1-11. PMID: 28849706. Article Request Form

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH

Ahmedani BK, Peterson EL, Hu Y, Rossom RC, Lynch F, Lu CY, Waitzfelder BE, Owen-Smith AA, Hubley S, Prabhakar D, Williams LK, Zeld N, Mutter E, Beck A, Tolsma D, and Simon GE. Major physical health conditions and risk of suicide Am J Prev Med 2017;PMID: 28619532. Full Text

Boggs JM, Simon GE, Ahmedani BK, Peterson E, Hubley S, and Beck A. The association of firearm suicide with mental illness, substance use conditions, and previous suicide attempts Ann Intern Med 2017;PMID: 28672343. Full Text

Boscarino JA, Moorman AC, Rupp LB, Zhou Y, Lu M, Teshale EH, Gordon SC, Spradling PR, Schmidt MA, Trinacty CM, Zhong Y, Holmberg SD, and Holtzman D. Comparison of icd-9 codes for depression and alcohol misuse to survey instruments suggests these codes should be used with caution Dig Dis Sci 2017; 62(10):2704- 2712. PMID: 28879547. Full Text

Cho J, Stock EM, Liao IC, Zeber JE, Ahmedani BK, Basu R, Quinn CC, and Copeland LA. Multiple chronic condition profiles and survival among oldest-old male patients with hip fracture Arch Gerontol Geriatr 2017; 74:184-190. PMID: 29126081. Full Text

Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA, Bauer Z, Avins AL, Nedeljkovic SS, Nerenz DR, Shi XR, Annaswamy T, Standaert CJ, Smuck M, Kennedy DJ, Akuthota V, Sibell D, Wasan AD, Diehn F, Suri P, Rundell SD, Kessler L, Chen AS, and Jarvik JG. Long term effects of repeated injections of local anesthetic with or without corticosteroid for lumbar spinal stenosis: a randomized trial Arch Phys Med Rehabil 2017;PMID: 28396242. Full Text

Gold LS, Bryan M, Comstock BA, Bresnahan BW, Deyo RA, Nedeljkovic SS, Nerenz DR, Heagerty P, and Jarvik JG. Associations between relative value units and patient-reported back pain and disability Gerontol Geriatr Med 2017; 3:2333721416686019. PMID: 28405596. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384601/

Gui H, Kwan JS, Sham PC, Cherny SS, and Li M. Sharing of genes and pathways across complex phenotypes: A multilevel genome-wide analysis Genetics 2017;PMID: 28495956. Full Text

Janssen T, Braciszewski JM, Vose-O'Neal A, and Stout RL. A comparison of long- vs. Short-term recall of substance use and hiv risk behaviors J Stud Alcohol Drugs 2017; 78(3):463-467. PMID: 28499115. Article Request Form

Keteyian CK, Nallamothu BK, and Ryan AM. The hospital tech laboratory: quality innovation in a new era of value- conscious care Am J Manag Care 2017; 23(8):501-504. PMID: 29087146. Full Text

Lanfear DE, Gibbs JJ, Li J, She R, Petucci C, Culver JA, Tang WHW, Pinto YM, Williams LK, Sabbah HN, and Gardell SJ. Targeted metabolomic profiling of plasma and survival in heart failure patients JACC Heart Fail 2017; 5(11):823-832. PMID: 29096792. Full Text

Lim HW, Collins SA, Resneck JS, Jr., Bolognia JL, Hodge JA, Rohrer TA, Van Beek MJ, Margolis DJ, Sober AJ, Weinstock MA, Nerenz DR, Smith Begolka W, and Moyano JV. The burden of skin disease in the United States J Am Acad Dermatol 2017;PMID: 28259441. Full text

Lim HW, Collins SAB, Resneck JS, Jr., Bolognia JL, Hodge JA, Rohrer TA, Van Beek MJ, Margolis DJ, Sober AJ, Weinstock MA, Nerenz DR, Smith Begolka W, and Moyano JV. Contribution of health care factors to the burden of skin disease in the United States J Am Acad Dermatol 2017;PMID: 28427793. Full Text

47 Lu M, Chacra W, Rabin D, Rupp LB, Trudeau S, Li J, and Gordon SC. Validity of an automated algorithm using diagnosis and procedure codes to identify decompensated cirrhosis using electronic health records Clin Epidemiol 2017; 9:369-376. PMID: 28744162. Full Text

Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D, Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, and North KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium PLoS Genet 2017; 13(4):e1006719. PMID: 28430825. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006719

Rossom RC, Coleman KJ, Ahmedani BK, Beck A, Johnson E, Oliver M, and Simon GE. Suicidal ideation reported on the PHQ9 and risk of suicidal behavior across age groups J Affect Disord 2017; 215:77-84. PMID: 28319695. Full Text

Salas J, Scherrer JF, Schneider FD, Sullivan MD, Bucholz KK, Burroughs T, Copeland LA, Ahmedani BK, and Lustman PJ. New-onset depression following stable, slow, and rapid rate of prescription opioid dose escalation Pain 2017; 158(2):306-312. PMID: 28092649. Full Text

Sherenian MG, Cho SH, Levin A, Min JY, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana JR, Serebrisky D, Avila PC, Kalhan R, Smith LJ, Borrell LN, Seibold MA, Keoki Williams L, Burchard EG, and Kumar R. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: the GALA II Cohort Clin Exp Allergy 2017;PMID: 28543872. Full Text

Shires DA, Schnaar A, Connolly MD, and Stroumsa D. To refer or not to refer: General pediatricians' perspectives on their role in caring for transgender youth Transgender Health 2017; 2(1):202-206. PMID: 29177196. Full Text

Stout RL, Janssen T, Braciszewski JM, and Vose-O'Neal A. Long-term recall of social relationships related to addiction and HIV risk behaviors Drug Alcohol Depend 2017; 177:124-129. PMID: 28599210. Full Text

Wolk CB, Jager-Hyman S, Marcus SC, Ahmedani BK, Zeber JE, Fein JA, Brown GK, Lieberman A, and Beidas RS. Developing implementation strategies for firearm safety promotion in paediatric primary care for suicide prevention in two large US health systems: a study protocol for a mixed-methods implementation study BMJ Open 2017; 7(6):e014407. PMID: 28647722. Full Text

Xing J, Spradling PR, Moorman AC, Holmberg SD, Teshale EH, Rupp LB, Gordon SC, Lu M, Boscarino JA, Schmidt MA, Trinacty CM, and Xu F. A point system to forecast hepatocellular carcinoma risk before and after treatment among persons with chronic hepatitis c Dig Dis Sci 2017; 62(11):3221-3234. PMID: 28965221. Full Text

Yang JJ, Williams LK, and Buu A. Identifying pleiotropic genes in genome-wide association studies for multivariate phenotypes with mixed measurement scales PLoS One 2017; 12(1):e0169893. PMID: 28081206. Full Text

Yang JJ, Williams LK, and Buu A. Identifying pleiotropic genes in genome-wide association studies from related subjects using the linear mixed model and Fisher combination function BMC Bioinformatics 2017; 18(1):376. PMID: 28836938. Full Text

Zeber JE, Coleman KJ, Fischer H, Yoon TK, Ahmedani BK, Beck A, Hubley S, Imel ZE, Rossom RC, Shortreed SM, Stewart C, Waitzfelder BE, and Simon GE. The impact of race and ethnicity on rates of return to psychotherapy for depression Depress Anxiety 2017;PMID: 29095538. Full Text

48 CLINICAL QUALITY AND SAFETY

Bardossy AC, Alsafadi MY, Starr P, Chami E, Pietsch J, Moreno D, Johnson L, Alangaden G, Zervos M, and Reyes K. Evaluation of contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus Am J Infect Control 2017;PMID: 28843943. Full Text

DERMATOLOGY

Agrawal S, Patel D, and Shwayder T. "X" marks the spot: An injection technique for alopecia areata Pediatr Dermatol 2017; 34(2):214-215. PMID: 28297148. Full Text

Bagel J, and Stein Gold L. Combining topical psoriasis treatment to enhance systemic and phototherapy: A review of the literature J Drugs Dermatol 2017; 16(12):1209-1222. PMID: 29240856. Article Request Form

Bourcier M, Stein Gold L, Guenther L, Andreassen CM, Selmer J, and Goldenberg G. A dose finding trial with a novel ingenol derivative (ingenol disoxate; LEO 43204) for field treatment of actinic keratosis on full face or 250cm2 on the chest J Dermatolog Treat 2017:1-25. PMID: 28264612. Article Request Form

Bousquet E, Zarbo A, Tournier E, Chevreau C, Mazieres J, Lacouture ME, and Sibaud V. Development of papulopustular rosacea during nivolumab therapy for metastatic cancer Acta Derm Venereol 2017; 97(4):539-540. PMID: 27826614. https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2566

Brown JR, Milgraum DM, Riyaz FR, Jahnke MN, and Thottam PJ. Successful placement of a baha implant in a patient with epidermolysis bullosa: A case report and review of the literature Ann Otol Rhinol Laryngol 2017; 126(11):778-780. PMID: 28895441. Full Text

Contributors include: C, Chaffins M, Ozog DM, and Powers M. The Scar Book: formation, mitigation, rehabilitation and prevention Wolters Kluwer 2017;PMID: ISBN 9781496322388. Sladen Library call number: WO 700 K89 2017

Chaowattanapanit S, Silpa-Archa N, Kohli I, Lim HW, and Hamzavi I. Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention J Am Acad Dermatol 2017; 77(4):607-621. PMID: 28917452. Full Text

Chung CL, Nadhan KS, Shaver CM, Ogrich LM, Abdelmalek M, Cusack CA, Malat GE, Pritchett EN, and Doyle A. Comparison of posttransplant dermatologic diseases by race JAMA Dermatol 2017;PMID: 28273280. Full Text

Dand N, Mucha S, Tsoi LC, Mahil SK, Stuart PE, Arnold A, Baurecht H, Burden AD, Callis Duffin K, Chandran V, Curtis CJ, Das S, Ellinghaus D, Ellinghaus E, Enerback C, Esko T, Gladman DD, Griffiths CEM, Gudjonsson JE, Hoffman P, Homuth G, Huffmeier U, Krueger GG, Laudes M, Lee SH, Lieb W, Lim HW, Lohr S, Mrowietz U, Muller- Nurayid M, Nothen M, Peters A, Rahman P, Reis A, Reynolds NJ, Rodriguez E, Schmidt CO, Spain SL, Strauch K, Tejasvi T, Voorhees JJ, Warren RB, Weichenthal M, Weidinger S, Zawistowski M, Nair RP, Capon F, Smith CH, Trembath RC, Abecasis GR, Elder JT, Franke A, Simpson MA, and Barker JN. Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling Hum Mol Genet 2017; 26(21):4301-4313. PMID: 28973304. Full Text

Eichenfield LF, and Stein Gold LF. Addressing the immunopathogenesis of atopic dermatitis: advances in topical and systemic treatment Semin Cutan Med Surg 2017; 36(2 Suppl 2):S45-s48. PMID: 28654711. Request Article

Eichenfield LF, and Stein Gold LF. Practical strategies for the diagnosis and assessment of atopic dermatitis Semin Cutan Med Surg 2017; 36(2 Suppl 2):S36-s38. PMID: 28654708. Request Article

Eichenfield LF, Call RS, Forsha DW, Fowler J, Jr., Hebert AA, Spellman M, Stein Gold LF, Van Syoc M, Zane LT, and Tschen E. Long-term safety of crisaborole ointment 2% in children and adults with mild to moderate atopic dermatitis J Am Acad Dermatol 2017;PMID: 28823881. Full Text

Friedman BJ, Griffith JL, and Chaffins ML. An elderly woman with painful annular erythematous plaques J Am Acad Dermatol 2017; 77(2):e25-e26. PMID: 28711096. Full Text

Giordano CN, Matarasso SL, and Ozog DM. Injectable and topical neurotoxins in dermatology: Indications, adverse events, and controversies J Am Acad Dermatol 2017; 76(6):1027-1042. PMID: 28522039. Full Text

Giordano CN, Matarasso SL, and Ozog DM. Injectable and topical neurotoxins in dermatology: Basic science, anatomy, and therapeutic agents J Am Acad Dermatol 2017; 76(6):1013-1024. PMID: 28522038. Full Text

49 Hamel RK, Madigan LM, and Hamzavi IH. Multiple lesions on the buttocks and groin J Am Acad Dermatol 2017; 77(2):e27-e28. PMID: 28711097. Full Text

Hamzavi IH, Sundaram M, Nicholson C, Zivkovic M, Parks-Miller A, Lee J, Yi J, Gu Y, Okun MM, Ganguli A, and Arikian SR. Uncovering burden disparity: A comparative analysis of the impact of moderate-to-severe psoriasis and hidradenitis suppurativa J Am Acad Dermatol 2017;PMID: 28917381. Full Text

Hao J, Lou Q, Wei Q, Mei S, Li L, Mi QS, Mei C, and Dong Z. MicroRNA-375 Is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-beta J Biol Chem 2017;PMID: 28119452. Full Text

Herndler-Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, and Flavell RA. Humanized mouse model supports development, function, and tissue residency of human natural killer cells Proc Natl Acad Sci U S A 2017; 114(45):E9626-e9634. PMID: 29078283. Full Text

Herzog SM, Lim HW, Williams MS, de Maddalena ID, Osterwalder U, and Surber C. Sun protection factor communication of sunscreen effectiveness: A web-based study of perception of effectiveness by dermatologists JAMA Dermatol 2017;PMID: 28146234. Full Text

Hoffman LK, Ghias MH, Garg A, Hamzavi IH, Alavi A, and Lowes MA. Major gaps in understanding and treatment of hidradenitis suppurativa Semin Cutan Med Surg 2017; 36(2):86-92. PMID: 28538750. Article Request Form

Jiang AJ, Eide MJ, Alexander GL, Altschuler A, Asgari MM, Geller AC, Fletcher SW, Halpern AC, and Weinstock MA. Providers' experiences with a melanoma web-based course: A discussion on barriers and intentions J Cancer Educ 2017; 32(2):272-279. PMID: 26391994. Article Request Form

Kailas A, Botwin AL, Pritchett EN, Jackson-Richards D, Lewis S, Sadhwani D, Desai SR, and Taylor SC. Assessing the effectiveness of knowledge-based interventions in increasing skin cancer awareness, knowledge, and protective behaviors in skin of color populations Cutis 2017; 100(4):235-240. PMID: 29136057. Full Text

Kircik L, Sung JC, Stein-Gold L, and Goldenberg G. United States food and drug administration product label changes J Clin Aesthet Dermatol 2017; 10(2):20-29. PMID: 28367259. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367870/

Kohli I, Shafi R, Isedeh P, Griffith JL, Al-Jamal MS, Silpa-Archa N, Jackson B, Athar M, Kollias N, Elmets CA, Lim HW, and Hamzavi IH. The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study J Am Acad Dermatol 2017;PMID: 28341348. Full Text

Krakowski AC, Ozog DM, Ginsberg D, Cheng C, and Chaffins ML. Laser-induced neocollagenesis in focal dermal hypoplasia associated with goltz syndrome in a girl JAMA Dermatol 2017;PMID: 28975212. Full Text

Levoska MA, Nicholson CL, and Hamzavi IH. A retrospective review of light- and laser-based management of hidradenitis suppurativa Semin Cutan Med Surg 2017; 36(2):67-74. PMID: 28538747. Article Request Form

Leyden J, Stein-Gold L, and Weiss J. Why Topical Retinoids Are Mainstay of Therapy for Acne Dermatol Ther (Heidelb) 2017;PMID: 28585191. Article Request Form

Li Z, Zhou Z, Hou X, Lu D, Yuan X, Lu J, Wang C, Han L, Cui L, Liu Z, Chen J, Cheng X, Zhang K, Ji J, Jia Z, Ma L, Xin Y, Liu T, Yu Q, Ren W, Wang X, Li X, Mi QS, Shi Y, and Li C. Replication of gout/urate concentrations gwas susceptibility loci associated with gout in a han chinese population Sci Rep 2017; 7(1):4094. PMID: 28642574. Full Text

Lim HW, Collins SA, Resneck JS, Jr., Bolognia JL, Hodge JA, Rohrer TA, Van Beek MJ, Margolis DJ, Sober AJ, Weinstock MA, Nerenz DR, Smith Begolka W, and Moyano JV. The burden of skin disease in the United States J Am Acad Dermatol 2017;PMID: 28259441. Full text

Lim HW, and Schneider SL. Sun safety practices-progress made, more to go JAMA Dermatol 2017;PMID: 28257532. Full text

Lim HW, Collins SAB, Resneck JS, Jr., Bolognia JL, Hodge JA, Rohrer TA, Van Beek MJ, Margolis DJ, Sober AJ, Weinstock MA, Nerenz DR, Smith Begolka W, and Moyano JV. Contribution of health care factors to the burden of skin disease in the United States J Am Acad Dermatol 2017;PMID: 28427793. Full Text

50 Liu Q, Zhang X, Yin C, Chen X, Zhang Z, Brown S, Xie H, Zhou L, and Mi QS. HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function Oncotarget 2017;PMID: 28177888. Full text

Mancuso JB, Maruthi R, Wang SQ, and Lim HW. Sunscreens: An update Am J Clin Dermatol 2017;PMID: 28510141. Article Request Form

Maranda EL, Sheinin R, Brys A, Rubin B, and Lim HW. A case of eosinophilic fasciitis associated with pyoderma gangrenosum J Eur Acad Dermatol Venereol 2017;PMID: 28150344. Full Text

Maranda EL, Riyaz F, and Shwayder T. Punch and scoop technique for removing pilomatricoma Pediatr Dermatol 2017;PMID: 28783214. Full Text

McKesey J, Berger TG, Lim HW, McMichael AJ, Torres A, and Pandya AG. Cultural competence for the 21st century dermatologist practicing in the United States J Am Acad Dermatol 2017;PMID: 28964536. Full Text

Menter A, Stein Gold L, Koo J, Villumsen J, Rosen M, and Lebwohl M. Fixed-combination calcipotriene plus betamethasone dipropionate aerosol foam is well tolerated in patients with psoriasis vulgaris: Pooled data from three randomized controlled studies Skinmed 2017; 15(2):119-124. PMID: 28528605. Article Request Form

Mohammad TF, Al-Jamal M, Hamzavi IH, Harris JE, Leone G, Cabrera R, Lim HW, Pandya AG, and Esmat SM. The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo J Am Acad Dermatol 2017;PMID: 28216034. Full text

Mohammad TF, and Hamzavi IH. Surgical therapies for vitiligo Dermatol Clin 2017; 35(2):193-203. PMID: 28317528. Full Text

Mohammad TF, Silpa-Archa N, Griffith JL, Lim HW, and Hamzavi IH. Home phototherapy in vitiligo Photodermatol Photoimmunol Photomed 2017;PMID: 28620923. Full Text

Nahhas AF, Mohammad TF, and Hamzavi IH. Vitiligo surgery: Shuffling melanocytes J Investig Dermatol Symp Proc 2017; 18(2):S34-s37. PMID: 28941491. Article Request Form

Paek SY, Hamzavi I, Danby FW, and Qureshi AA. Disease modification for hidradenitis suppurativa: A new paradigm J Am Acad Dermatol 2017; 76(4):772-773. PMID: 28325401. Full Text

Pariser D, Bukhalo M, Guenthner S, Kempers S, Shideler S, Gold LS, Tschen E, Berg J, Ferdon MB, and Dromgoole S. Two multicenter, randomized, double-blind, parallel group comparison studies of a novel enhanced lotion formulation of halobetasol propionate, 0.05% versus its vehicle in adult subjects with plaque psoriasis J Drugs Dermatol 2017; 16(3):234-240. PMID: 28301619. Full Text

Paul C, Leonardi C, Menter A, Reich K, Stein Gold L, Warren RB, Moller A, and Lebwohl M. Calcipotriol plus betamethasone dipropionate aerosol foam in patients with moderate-to-severe psoriasis: Sub-group analysis of the pso-able study Am J Clin Dermatol 2017;PMID: 28236223. Article request form

Paul C, Leonardi C, Menter A, Reich K, Stein Gold L, Warren RB, Moller A, and Lebwohl M. Erratum to: Calcipotriol plus betamethasone dipropionate aerosol foam in patients with moderate-to-severe psoriasis: Sub- group analysis of the pso-able study Am J Clin Dermatol 2017;PMID: 28540589. Article Request Form

Porto DA, Wang SQ, and Lim HW. Counseling patients on photoprotection: What the dermatologist needs to know JAMA Dermatol 2017; 153(1):110. PMID: 28114519. Full Text

Powers MC, Mehta D, and Ozog D. Cutting out the tracts: Staged excisions for dissecting cellulitis of the scalp Dermatol Surg 2017;PMID: 28221182. Full text

Puiu T, Porto DA, Siddiqui F, and Lim HW. Tumor-stage mycosis fungoides regressing with milia and pustules after total skin electron beam therapy J Eur Acad Dermatol Venereol 2017;PMID: 28557155. Full Text

Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, and Harris JE. Current and emerging treatments for vitiligo J Am Acad Dermatol 2017; 77(1):17-29. PMID: 28619557. Full Text

Rodrigues M, Ezzedine K, Hamzavi I, Pandya AG, and Harris JE. New discoveries in the pathogenesis and classification of vitiligo J Am Acad Dermatol 2017; 77(1):1-13. PMID: 28619550. Full Text

51 Schneider SL, Patel D, and Shwayder TA. Teenage boy with thickened dorsal hands and feet Pediatr Dermatol 2017; 34(6):719-720. PMID: 29144048. Full Text

Schneider S, Levandowski CB, Manly C, Dellavalle R, and Dunnick CA. Wilderness dermatology: Mountain exposures Dermatology Online Journal 2017; 23(11)PMID: Not yet assigned. Article Request Form

Schueller F, Roy S, Loosen SH, Alder J, Koppe C, Schneider AT, Wandrer F, Bantel H, Vucur M, Mi QS, Trautwein C, Luedde T, and Roderburg C. MiR-223 represents a biomarker in acute and chronic liver injury Clin Sci (Lond) 2017;PMID: 28646120. Article Request Form

Shan W, Jiang Y, Yu H, Huang Q, Liu L, Guo X, Li L, Mi Q, Zhang K, and Yang Z. HDAC2 overexpression correlates with aggressive clinicopathological features and DNA-damage response pathway of breast cancer Am J Cancer Res 2017; 7(5):1213-1226. PMID: 28560068. Full Text

Shwayder T. In Memoriam: Arnold Pieter Oranje, M.D., Ph.D. (August 7, 1948 to October 19, 2016) Pediatr Dermatol 2017; 34(3):229-230. PMID: 28523879. Full Text

Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, Mulekar SV, Lim HW, and Hamzavi IH. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas J Am Acad Dermatol 2017;PMID: 28502377. Full Text

Silpa-Archa N, Kohli I, Chaowattanapanit S, Lim HW, and Hamzavi I. Postinflammatory hyperpigmentation: A comprehensive overview: Epidemiology, pathogenesis, clinical presentation, and noninvasive assessment technique J Am Acad Dermatol 2017; 77(4):591-605. PMID: 28917451. Full Text

Smith MK, Mohammad TF, and Hamzavi IH. Assessment of dietary supplementation in the treatment of vitiligo Open Dermatol J 2017; 11:12-21. PMID: Not assigned. Article Request Form

Smith MK, Nicholson CL, Parks-Miller A, and Hamzavi IH. Hidradenitis suppurativa: an update on connecting the tracts F1000Res 2017; 6:1272. PMID: 28794864. Full Text

Spring LK, Krakowski AC, Alam M, Bhatia A, Brauer J, Cohen J, Del Rosso JQ, Diaz L, Dover J, Eichenfield LF, Gurtner GC, Hanke CW, Jahnke MN, Kelly KM, Khetarpal S, Kinney MA, Levy ML, Leyden J, Longaker MT, Munavalli GS, Ozog DM, Prather H, Shumaker PR, Tanzi E, Torres A, Velez MW, Waldman AB, Yan AC, and Zaenglein AL. Isotretinoin and timing of procedural interventions: A systematic review with consensus recommendations JAMA Dermatol 2017; 153(8):802-809. PMID: 28658462. Full Text

Stein Gold LF, and Eichenfield LF. Nonpharmacologic strategies and topical agents for treating atopic dermatitis: an update Semin Cutan Med Surg 2017; 36(2 Suppl 2):S42-s44. PMID: 28654710. Request Article

Stein Gold LF, and Eichenfield LF. Atopic dermatitis progression: evaluating intervention strategies Semin Cutan Med Surg 2017; 36(2 Suppl 2):S39-s41. PMID: 28654709. Request Article

Stein Gold LS, Papp K, Lynde C, Lain E, Gooderham M, Johnson S, and Kerrouche N. Treatment of rosacea with concomitant use of topical ivermectin 1% cream and brimonidine 0.33% gel: A randomized, vehicle-controlled study J Drugs Dermatol 2017; 16(9):909-916. PMID: 28915286. Article Request Form

Stein Gold L, Baldwin HE, and Lin T. Management of severe acne vulgaris with topical therapy J Drugs Dermatol 2017; 16(11):1134-1138. PMID: 29141062. Article Request Form

Strober B, Bagel J, Lebwohl M, Stein Gold L, Jackson JM, Chen R, Goncalves J, Levi E, and Callis Duffin K. Efficacy and safety of apremilast in patients with moderate plaque psoriasis with lower bsa: Week 16 results from the unveil study J Drugs Dermatol 2017; 16(8):801-808. PMID: 28809995. Article Request Form

Sugarman JL, Stein Gold L, Lebwohl MG, Pariser DM, Alexander BJ, and Pillai R. A phase 2, multicenter, double- blind, randomized, vehicle controlled clinical study to assess the safety and efficacy of a halobetasol/tazarotene fixed combination in the treatment of plaque psoriasis J Drugs Dermatol 2017; 16(3):197-204. PMID: 28301614. Full Text

52 Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, Ellinghaus E, Barker JN, Chandran V, Dand N, Duffin KC, Enerback C, Esko T, Franke A, Gladman DD, Hoffmann P, Kingo K, Koks S, Krueger GG, Lim HW, Metspalu A, Mrowietz U, Mucha S, Rahman P, Reis A, Tejasvi T, Trembath R, Voorhees JJ, Weidinger S, Weichenthal M, Wen X, Eriksson N, Kang HM, Hinds DA, Nair RP, Abecasis GR, and Elder JT. Large scale meta- analysis characterizes genetic architecture for common psoriasis associated variants Nat Commun 2017; 8:15382. PMID: 28537254. Full Text

Uzoma M, Singh G, and Kohen L. Green palmoplantar vesicular eruption in a patient with hyperbilirubinemia JAAD Case Rep 2017; 3(4):273-275. PMID: 28653028. Full Text van Geel N, Boniface K, Seneschal J, Jacquemin C, Speeckaert R, Wolkerstorfer A, Bekkenk M, Lommerts JE, Hamzavi I, Pandya A, Eleftheriadou V, Ezzedine K, Giannarelli D, Gnarra M, Sperduti I, Prinsen C, Harris J, Taieb A, and Picardo M. Meeting report: Vitiligo Global Issues Consensus Conference (VGICC) Workshop "Outcome measurement instruments" and Vitiligo International Symposium, Rome, Nov 30-Dec 3rd Pigment Cell Melanoma Res 2017;PMID: 28379638. Full Text

Wang J, Yang Q, Zhang Q, Yin C, Zhou L, Zhou J, Wang Y, and Mi QS. Invariant natural killer T cells ameliorate monosodium urate crystal-induced gouty inflammation in mice Front Immunol 2017; 8(DEC)PMID: Not assigned. Article Request Form

Zabetian S, Jacobson G, Lim HW, Eide MJ, and Huggins RH. Quality of life in a vitiligo support group J Drugs Dermatol 2017; 16(4):344-350. PMID: 28403268. Full Text

Zhang M, Goyert G, and Lim HW. Folate and phototherapy: What should we inform our patients? J Am Acad Dermatol 2017; 77(5):958-964. PMID: 29029903. Full Text

Zhang X, Yao Y, Wei WZ, Yang ZQ, Gu J, and Zhou L. Impaired epidermal Langerhans cell maturation in TGFβ- inducible early gene 1 (TIEG1) knockout mice Oncotarget 2017; 8(68):112875-112882. PMID: Not assigned. Article Request Form

DIAGNOSTIC RADIOLOGY

Abdollah F, Dalela D, Sood A, Sammon J, Cho R, Nocera L, Diaz M, Jeong W, Peabody JO, Fossati N, Gandaglia G, Briganti A, Montorsi F, and Menon M. Functional outcomes of clinically high-risk prostate cancer patients treated with robot-assisted radical prostatectomy: a multi-institutional analysis Prostate Cancer Prostatic Dis 2017;PMID: 28462944. Article Request Form

Akers SR, Panchal V, Ho VB, Beache GM, Brown RKJ, Ghoshhajra BB, Greenberg SB, Hsu JY, Kicska GA, Min JK, Stillman AE, Stojanovska J, Abbara S, and Jacobs JE. Acr appropriateness criteria(r) chronic chest pain-high probability of coronary artery disease J Am Coll Radiol 2017; 14(5s):S71-s80. PMID: 28473096. Full Text

Baumer TG, Davis L, Dischler J, Siegal DS, van Holsbeeck M, Moutzouros V, and Bey MJ. Shear wave elastography of the supraspinatus muscle and tendon: Repeatability and preliminary findings J Biomech 2017;PMID: 28110933. Full Text

Baumer TG, Dischler J, Mende V, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of asymptomatic rotator cuff pathology on in vivo shoulder motion and clinical outcomes J Shoulder Elbow Surg 2017;PMID: 28131679. Full Text

Chetlen AL, Degnan AJ, Guelfguat M, Griffith B, Itri J, Matta H, Tong A, Flug J, Toy D, Consul N, Walker E, Spalluto L, Smith AD, and Krupinski EA. Radiology research funding. Current state and future opportunities Acad Radiol 2017;PMID: Not assigned. Full Text

Frisch NB, Wessell NM, Taliaferro K, Van Holsbeeck M, and Silverton CD. Ultrasound findings in asymptomatic patients with modular metal on metal total hip arthroplasty Skeletal Radiol 2017;PMID: 28204856. Full text

Frisoli TM, Jain T, Swadia T, Hong X, and Guerrero M. Cardiac tamponade due to pyopneumopericardium from malignant bronchopericardial fistula Neth Heart J 2017;PMID: 28349347. Article Request Form

Kahlon PS, Mishra A, Williams TR, Sandhu NK, Donthireddy V, and Dobrostoskaya I. Diagnosing primary squamous cell cancer of the rectum in a patient with hiv: A case report J Oncol Pract 2017:Jop2016019901. PMID: 28557660. Article Request Form

53 Kelley BP, Patel SC, Marin HL, Corrigan JJ, Mitsias PD, and Griffith B. Autoimmune encephalitis: Pathophysiology and imaging review of an overlooked diagnosis AJNR Am J Neuroradiol 2017;PMID: 28183838. Full text

Kralik SF, O'Neill DP, Kamer AP, Rodriguez E, and Ho CY. Radiological diagnosis of drop metastases from paediatric brain tumours using combination of 2D and 3D MRI sequences Clin Radiol 2017;PMID: 28545686. Full Text

Larson DB, Durand DJ, and Siegal DS. Understanding and applying the concept of value creation in radiology J Am Coll Radiol 2017;PMID: 28223112. Full text

Lee C, Flynn MJ, Judy PF, Cody DD, Bolch WE, and Kruger RL. Body size-specific organ and effective doses of chest ct screening examinations of the national lung screening trial AJR Am J Roentgenol 2017:1-7. PMID: 28267354. Full Text

Lin D, and Rheinboldt M. Reversible splenial lesions presenting in conjunction with febrile illness: a case series and literature review Emerg Radiol 2017;PMID: 28523438. Full Text

Lin T, Lin D, Zhang Z, and Shah BA. Metastatic endometrial serous carcinoma to the breast Appl Radiol 2017; 46(11):42-45. PMID: Not assigned. Article Request Form

Lourenco AP, Benson KL, Henderson MC, Silver M, Letsios E, Tran Q, Gordon KJ, Borman S, Corn C, Mulpuri R, Smith W, Alpers J, Costantini C, Rohatgi N, Yang R, Ali H, Shah B, Morris M, Kass F, and Reese DE. A noninvasive blood-based combinatorial proteomic biomarker assay to detect breast cancer in women under the age of 50 years Clin Breast Cancer 2017;PMID: 28624156. Full Text

Moriarity AK, Green A, Klochko C, O'Brien M, and Halabi S. Evaluating the effect of unstructured clinical information on clinical decision support appropriateness ratings J Am Coll Radiol 2017;PMID: 28434848. Full Text

Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, Thomas C, Franceschi AM, Griffith B, Flanders A, Golfinos JG, Chi AS, and Jain R. T2-flair mismatch, an imaging biomarker for idh and 1p/19q status in lower grade gliomas: A tcga/tcia project Clin Cancer Res 2017;PMID: 28751449. Full Text

Rodriguez E, Silva JM, and Astani SA. Giant splenic pseudocyst Appl Radiol 2017; 46(7):40-42. PMID: Not assigned. Request Article

Rountree KM, and Blase JJ. Isolated orbital roof blow-in fracture Trauma Case Rep 2017; 12:16-18. PMID: Not assigned. Article Request Form

Sever AJ, Patel C, Albeer Y, and Darian VB. The technique and benefits of angiographic embolization of inferior epigastric arteries prior to pedicled tram flap breast reconstruction: Results from a single center Cardiovasc Intervent Radiol 2017;PMID: 28536869 Full Text

Shukla M, Keller R, Marshall N, Ahmed H, Scher C, Moutzouros VB, and van Holsbeeck M. Ultrasound evaluation of the ulnar collateral ligament of the elbow: Which method is most reproducible? Skeletal Radiol 2017;PMID: 28424849. Full Text

Singh H, Handa R, Arshad Z, and Hoover EG. Case of tumoral calcinosis on images: a rare clinicopathological entity BMJ Case Rep 2017; 2017PMID: 29066642. Full Text

Spain JA, Rheinboldt M, Parrish D, and Rinker E. Morel-lavallee injuries: A multimodality approach to imaging characteristics Acad Radiol 2017; 24(2):220-225. PMID: 28087046. Full Text

Spain JA, Shaikh S, and Sandberg SA. Sonographic findings and diagnostic pitfalls in evaluation for uterine rupture in a case of fetal demise and prior cesarean delivery of unknown type Ultrasound Q 2017;PMID: 28081020. Full Text

Stone M, Eyler W, Rhodenizer J, and van Holsbeeck M. Accuracy of sonography in plantar plate tears in cadavers J Ultrasound Med 2017;PMID: 28398696. Full Text

Varkey J, Astani SA, Pantelic M, and Dalal I. Rare case of angiosarcoma of the adrenal gland seen with multiple modalities Appl Radiol 2017; 46(10):30-32. PMID: Not assigned. Article Request Form

Vasileff WK, Nekhline M, Kolowich PA, Talpos GB, Eyler WR, and van Holsbeeck M. Inguinal hernia in athletes: Role of dynamic ultrasound Sports Health 2017:1941738117717009. PMID: 28732177. Full Text

54 EMERGENCY MEDICINE

Anderson EL, Nordstrom K, Wilson MP, Peltzer-Jones JM, Zun L, Ng A, and Allen MH. American association for emergency psychiatry task force on medical clearance of adults part i: Introduction, review and evidence-based guidelines West J Emerg Med 2017; 18(2):235-242. PMID: 28210358. Full text

Berger RE, Rivers E, and Levy MM. Management of Septic Shock N Engl J Med 2017; 376(23):2282- 2285. PMID: 28591533. Full Text

Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, and Brower RG. Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study Crit Care Med 2017; 45(8):1317-1324. PMID: 28538439. Full Text

Collins SP, Thorn M, Nowak RM, Levy PD, Fermann GJ, Hiestand BC, Cowart TD, Venuti RP, Hiatt WR, Foo S, and Pang PS. Feasibility of serial 6-min walk tests in patients with acute heart failure J Clin Med 2017; 6(9)PMID: 28891981. Full Text

Connor-Schuler R, Khan A, Goyal N, and Zimny E. Pressor support during a Jarisch Herxheimer reaction after initiation of treatment for Weil's disease Am J Emerg Med 2017;PMID: 28527874. Full Text

Coz Yataco A, Jaehne AK, and Rivers EP. Protocolized early sepsis care is not only helpful for patients: It prevents medical errors Crit Care Med 2017;PMID: 28098592. Full Text

Frisoli TM, Nowak R, Evans KL, Harrison M, Alani M, Varghese S, Rahman M, Noll S, Flannery KR, Michaels A, Tabaku M, Jacobsen G, and McCord J. Henry Ford HEART score randomized trial: Rapid discharge of patients evaluated for possible myocardial infarction Circ Cardiovasc Qual Outcomes 2017; 10(10)PMID: 28954802. Full Text

Gaggin HK, Chen-Tournoux AA, Christenson RH, Doros G, Hollander JE, Levy PD, Nagurney JT, Nowak RM, Pang PS, Patel D, Peacock WF, Walters EL, and Januzzi JL. Rationale and design of the icon-reloaded study: International collaborative of n-terminal pro-b-type natriuretic peptide re-evaluation of acute diagnostic cut-offs in the emergency department Am Heart J 2017; 192:26-37. PMID: 28938961. Full Text

Garcia L, and Ito K. Lemierre's syndrome presented with acute pancreatitis Acute Medicine and Surgery 2017;PMID: Not assigned. Full Text

Gingold DB, Pierre-Mathieu R, Cole B, Miller AC, and Khaldun JS. Impact of the Affordable Care Act Medicaid expansion on emergency department high utilizers with ambulatory care sensitive conditions: A cross-sectional study Am J Emerg Med 2017;PMID: 28110978. Full Text

Harmouche E, Goyal N, Pinawin A, Nagarwala J, and Bhat R. Usmle scores predict success in abem initial certification: A multicenter study West J Emerg Med 2017; 18(3):544-549. PMID: 28435509. Full Text

Harmouche E, Mahmoud GA, Ross M, Hockenberry J, Dharia R, and Nahab F. Early echocardiography has a low yield in patients with transient ischemic attack J Stroke Cerebrovasc Dis 2017;PMID: 28506591. Full Text

Jayaprakash N, Gajic O, Frank RD, and Smischney N. Elevated modified shock index in early sepsis is associated with myocardial dysfunction and mortality J Crit Care 2017; 43:30-35. PMID: 28843067. Full Text

Liroff MG. Uncomplicated J Emerg Med 2017;PMID: 28844404. Full Text

Liroff MG. I'll Fly Away Ann Emerg Med 2017; 70(5):741. PMID: 29056208. Full Text

Liroff MG. Off the Monitor Ann Emerg Med 2017; 70(6):912. PMID: 29157689. Full Text

Manthey DE, Hartman ND, Newmyer A, Gunalda JC, Hiestand BC, and Askew KL. Trends in NRMP data from 2007- 2014 for U.S. seniors matching into emergency medicine West J Emerg Med 2017; 18(1):105-109. PMID: 28116018. Full Text

Manthey DE, Hartman ND, Newmyer A, Gunalda JC, Hiestand BC, and Askew KL. Erratum: This article corrects: "Trends in nrmp data from 2007-2014 for u.S. Seniors matching into emergency medicine" West J Emerg Med 2017; 18(3):550. PMID: 28435510. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391909/

55 McCord J, Cabrera R, Lindahl B, Giannitsis E, Evans K, Nowak R, Frisoli T, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, and Mueller C. Prognostic utility of a modified HEART score in chest pain patients in the emergency department Circ Cardiovasc Qual Outcomes 2017; 10(2)PMID: 28167641. Full text

Miller JB, Nowak RM, Reed BP, DiSomma S, Nanayakkara P, Moyer M, Millis S, Kinni H, and Levy P. Hemodynamic characteristics of suspected stroke in the emergency department Am J Emerg Med 2017;PMID: 28811213. Full Text

Miller JB, Arter A, Wilson SS, Janke AT, Brody A, Reed BP, and Levy PD. Appropriateness of bolus antihypertensive therapy for elevated blood pressure in the emergency department West J Emerg Med 2017; 18(5):957-962. PMID: 28874950. Full Text

Morotti A, Romero JM, Jessel MJ, Hernandez AM, Vashkevich A, Schwab K, Burns JD, Shah QA, Bergman TA, Suri MFK, Ezzeddine M, Kirmani JF, Agarwal S, Shapshak AH, Messe SR, Venkatasubramanian C, Palmieri K, Lewandowski C, Chang TR, Chang I, Rose DZ, Smith W, Hsu CY, Liu CL, Lien LM, Hsiao CY, Iwama T, Afzal MR, Cassarly C, Greenberg SM, Martin RH, Qureshi AI, Rosand J, Boone JM, and Goldstein JN. Phantom-based standardization of CT angiography images for spot sign detection Neuroradiology 2017;PMID: 28730267. Full Text

Morris DC, Cheung WL, Loi R, Zhang T, Lu M, Zhang ZG, and Chopp M. Thymosin beta4 for the treatment of acute stroke in aged rats Neurosci Lett 2017; 659:7-13. PMID: 28864242. Full Text

Nowak R, Muller C, Giannitsis E, Christ M, Ordonez-Llanos J, DeFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Jacobsen G, Dinkel C, and Lindahl B. High sensitivity cardiac troponin t in patients not having an acute coronary syndrome: Results from the trapid-ami study Biomarkers 2017:1-26. PMID: 28532247. Article Request Form

Pang PS, Lane KA, Tavares M, Storrow AB, Shen C, Peacock WF, Nowak R, Mebazaa A, Laribi S, Hollander JE, Gheorghiade M, and Collins SP. Is there a clinically meaningful difference in patient reported dyspnea in acute heart failure? An analysis from URGENT Dyspnea Heart Lung 2017;PMID: 28433323. Full Text

Rafique Z, Kosiborod M, Clark CL, Singer AJ, Turner S, Miller J, Char D, and Peacock WF. Study design of real world evidence for treatment of hyperkalemia in the emergency department (reveal-ed): A multicenter, prospective, observational study Clin Exp Emerg Med 2017; 4(3):154-159. PMID: 29026889. Full Text

Salem D, and Delibasic M. Endovascular approach to treat median arcuate ligament compressing syndrome Vascular Disease Management 2017; 14(2):E37-E45. PMID: Not assigned.

Schuetz P, Birkhahn R, Sherwin R, Jones AE, Singer A, Kline JA, Runyon MS, Self WH, Courtney DM, Nowak RM, Gaieski DF, Ebmeyer S, Johannes S, Wiemer JC, Schwabe A, and Shapiro NI. Serial procalcitonin predicts mortality in severe sepsis patients: Results from the multicenter procalcitonin monitoring sepsis (MOSES) study Crit Care Med 2017;PMID: 28257335. Full text

Wilson SP, Vohra T, Knych M, Goldberg J, Price C, Calo S, Mahan M, and Miller J. Gonorrhea and chlamydia in the emergency department: Continued need for more focused treatment for men, women and pregnant women Am J Emerg Med 2017;PMID: 28073612. Full Text

Wilson MP, Nordstrom K, Anderson EL, Ng AT, Zun LS, Peltzer-Jones JM, and Allen MH. American association for emergency psychiatry task force on medical clearance of adult psychiatric patients. Part ii: Controversies over medical assessment, and consensus recommendations West J Emerg Med 2017; 18(4):640-646. PMID: 28611885. Full Text

Wilson SP, Vohra T, Goldberg J, Price C, Calo S, Mahan M, and Miller J. Reliable rapid assay for gonorrhea and chlamydia in the emergency department J Emerg Med 2017;PMID: 29074030. Full Text

FAMILY MEDICINE

Bryce R, Guajardo C, Ilarraza D, Milgrom N, Pike D, Savoie K, Valbuena F, and Miller-Matero LR. Participation in a farmers' market fruit and vegetable prescription program at a federally qualified health center improves hemoglobin A1C in low income uncontrolled diabetics Prev Med Rep 2017; 7:176-179. PMID: 28702315. Full Text

56 Kwarteng JL, Schulz AJ, Mentz GB, Israel BA, and White-Perkins D. Independent effects of neighborhood poverty and psychosocial stress on obesity over time J Urban Health 2017;PMID: 28895036. Full Text

Park B, Vemulapalli RC, Gupta A, Shreve ME, and Rees DA. Docetaxel-induced systemic sclerosis with internal organ involvement masquerading as congestive heart failure Case Reports Immunol 2017; 2017:4249157. PMID: 28265474. Full Text

Park B, Vemulapalli RC, Gupta A, Shreve ME, and Rees DA. Corrigendum to "docetaxel-induced systemic sclerosis with internal organ involvement masquerading as congestive heart failure" Case Reports Immunol 2017; 2017:4809124. PMID: 28690907. Full Text

GLOBAL HEALTH INITIATIVE

Ayau P, Bardossy AC, Sanchez G, Ortiz R, Moreno D, Hartman P, Rizvi K, Prentiss TC, Perri MB, Mahan M, Huang V, Reyes K, and Zervos MJ. Risk factors for 30-day mortality in patients with methicillin-resistant staphylococcus aureus bloodstream infections Int J Infect Dis 2017;PMID: 28533166. Full Text

Mendo-Lopez R, Jasso L, Guevara X, Astocondor AL, Alejos S, Bardossy AC, Prentiss T, Zervos MJ, Jacobs J, and Garcia C. Multidrug-resistant microorganisms colonizing lower extremity wounds in patients in a tertiary care hospital, Lima, Peru Am J Trop Med Hyg 2017;PMID: 28722595. Request Article

Newman LA, and Kaljee LM. Health disparities and triple-negative breast cancer in african american women: A review JAMA Surg 2017;PMID: 28355428. Full Text

Raccurt CP, Brasseur P, Ciceron M, Parke DM, Zervos MJ, and Boncy J. In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti Malar J 2017; 16(1):313. PMID: 28778206. Full Text

GRADUATE MEDICAL EDUCATION

Baker-Genaw K, and Gyiraszin C. A mathematical formula for institutional gme program support J Grad Med Educ 2017; 9(3):370-371. PMID: 28638521. Full Text

Tatem G, Kokas M, Smith CL, and DiGiovine B. A feasibility assessment of behavioral-based interviewing to improve candidate selection for a pulmonary and critical care medicine fellowship program Ann Am Thorac Soc 2017;PMID: 28306323. Full Text

Tatem G, Kokas M, Smith CL, and DiGiovine B. Reply: Combining efforts for positive progress in the graduate medical education match process Ann Am Thorac Soc 2017; 14(8):1358-1359. PMID: 28723245. Full Text

INTERNAL MEDICINE

Allergy and Immunology

Brown KR, Krouse RZ, Calatroni A, Visness CM, Sivaprasad U, Kercsmar CM, Matsui EC, West JB, Makhija MM, Gill MA, Kim H, Kattan M, Pillai D, Gern JE, Busse WW, Togias A, Liu AH, and Khurana Hershey GK. Endotypes of difficult-to-control asthma in inner-city African American children PLoS One 2017; 12(7):e0180778. PMID: 28686637. Full Text

Esquivel A, Busse WW, Calatroni A, Togias AG, Grindle KG, Bochkov YA, Gruchalla RS, Kattan M, Kercsmar CM, Khurana Hershey G, Kim H, Lebeau P, Liu AH, Szefler SJ, Teach SJ, West JB, Wildfire J, Pongracic JA, and Gern JE. Effects of omalizumab on rhinovirus infections, illnesses and exacerbations of asthma Am J Respir Crit Care Med 2017;PMID: 28608756. Full Text

Fonseca W, Lucey K, Jang S, Fujimura KE, Rasky A, Ting HA, Petersen J, Johnson CC, Boushey HA, Zoratti E, Ownby DR, Levine AM, Bobbit KR, Lynch SV, and Lukacs NW. Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation Mucosal Immunol 2017;PMID: 28295020. Article Request Form

Havstad S, Sitarik AR, Johnson CC, Zoratti EM, Ownby DR, Levin AM, and Wegienka G. Allergic sensitization in American children of Middle Eastern ethnicity at age 2 Ann Allergy Asthma Immunol 2017;PMID: 28941706. Full Text

57 Hoch HE, Calatroni A, West JB, Liu AH, Gergen PJ, Gruchalla RS, Hershey KG, Kercsmar CM, Kim H, Lamm CI, Makhija MM, Mitchell HE, Teach SJ, Wildfire JJ, Busse WW, and Szefler SJ. Can we predict fall asthma exacerbations? Validation of the seasonal asthma exacerbation index J Allergy Clin Immunol 2017;PMID: 28238748. Full text

Khan U, Ali F, Khurram MS, Zaka A, and Hadid T. Immunotherapy-associated autoimmune hemolytic anemia J Immunother Cancer 2017; 5(1)PMID: 28239468. Full text

Liu AH, Zoratti EM, Pongracic JA, Babineau DC, Visness CM, Gergen PJ, Togias A, and Busse WW. The multimorbid polysensitized phenotype is associated with the severity of allergic diseases Reply J Allergy Clin Immunol 2017; 139(4):1408-1409. PMID: Not assigned. Full Text

Liu AH, Zoratti EM, Pongracic JA, Babineau DC, Visness CM, Gergen PJ, Togias A, and Busse WW. Reply J Allergy Clin Immunol 2017;PMID: 28237730. Full text

Poowuttikul P, Hart B, Thomas R, and Secord E. Poor adherence with medication refill and medical supplies maintenance as risk factors for inpatient asthma admission in children Glob Pediatr Health 2017; 4:2333794x17710588. PMID: 28607943. Full Text

Sitarik AR, Bobbitt KR, Havstad SL, Fujimura KE, Levin AM, Zoratti EM, Kim H, Woodcroft KJ, Wegienka G, Ownby DR, Joseph CL, Lynch SV, and Johnson CC. Breast milk tgfbeta is associated with neonatal gut microbial composition J Pediatr Gastroenterol Nutr 2017;PMID: 28362692. Full Text

Sitarik AR, Bobbitt KR, Havstad SL, Fujimura KE, Levin AM, Zoratti EM, Kim H, Woodcroft KJ, Wegienka G, Ownby DR, Joseph CLM, Lynch SV, and Johnson CC. Breast milk transforming growth factor beta is associated with neonatal gut microbial composition J Pediatr Gastroenterol Nutr 2017; 65(3):e60-e67. PMID: 28827481. Full Text

Cardiology/Cardiovascular Research

Ahmed HM, Al-Mallah MH, Keteyian SJ, Brawner CA, Ehrman JK, Zhao DI, Guallar E, Blaha MJ, and Michos ED. Sex-specific maximum predicted heart rate and its prognosis for mortality and myocardial infarction Med Sci Sports Exerc 2017; 49(8):1704-1710. PMID: 28708776. Full Text

Aladin AI, Al Rifai M, Rasool SH, Keteyian SJ, Brawner CA, Blumenthal RS, Blaha MJ, Al-Mallah MH, and McEvoy JW. Relation of resting heart rate to incident atrial fibrillation (from the henry ford hospital exercise testing project) Am J Cardiol 2017; 119(2):262-267. PMID: 28126149. Full Text

Alghamdi M, Al-Mallah M, Keteyian S, Brawner C, Ehrman J, and Sakr S. Predicting diabetes mellitus using SMOTE and ensemble machine learning approach: The Henry Ford ExercIse Testing (FIT) project PLoS One 2017; 12(7):e0179805. PMID: 28738059. Full Text

Al-Mallah MH. Introduction to the special issue: Myocardial imaging in heart failure Heart Fail Rev 2017; 22(4):381- 383. PMID: 28620744. Full Text

Al-Mallah MH, Elshawi R, Ahmed AM, Qureshi WT, Brawner CA, Blaha MJ, Ahmed HM, Ehrman JK, Keteyian SJ, and Sakr S. Using machine learning to define the association between cardiorespiratory fitness and all-cause mortality (from the henry ford exercise testing project) Am J Cardiol 2017;PMID: 28951020. Full Text

Aurora L, and McCord J. Drugs to Avoid in Acute Decompensated Heart Failure (ADHF): Contraindicated Medications and Interactions Short Stay Management of Acute Heart Failure, 3rd Edition 2017; by W. Frank Peacock (Editor) Springer International AG SwitzerlandPMID: Not assigned - book chapter. Article Request Form

Babaliaros VC, Greenbaum AB, Khan JM, Rogers T, Wang DD, Eng MH, O'Neill WW, Paone G, Thourani VH, Lerakis S, Kim DW, Chen MY, and Lederman RJ. Intentional percutaneous laceration of the anterior mitral leaflet to prevent outflow obstruction during transcatheter mitral valve replacement: First-in-human experience JACC Cardiovasc Interv 2017; 10(8):798-809. PMID: 28427597. Full Text

Basir MB, Karatasakis A, Alqarqaz M, Danek B, Rangan BV, Brilakis ES, Kim H, O'Neill WW, and Alaswad K. Further validation of the hybrid algorithm for CTO PCI; difficult lesions, same success Cardiovasc Revasc Med 2017;PMID: 28314674. Full Text

58 Brawner CA, Al-Mallah MH, Ehrman JK, Qureshi WT, Blaha MJ, and Keteyian SJ. Change in maximal exercise capacity is associated with survival in men and women Mayo Clin Proc 2017;PMID: 28185659. Full text

Brawner CA, and Keteyian SJ. Do we need another walking test? JACC Heart Fail 2017; 5(6):421-422. PMID: 28501526. Full Text

Broughton ST, O'Neal WT, Al-Mallah M, Bluemke DA, Heckbert SR, Lima JAC, and Soliman EZ. Normal findings on noninvasive cardiac assessment and the prediction of heart failure: The Multi-Ethnic Study of Atherosclerosis (MESA) Int J Cardiol 2017; 249:308-312. PMID: 29121731. Full Text

Butler J, Hamo CE, Udelson JE, O'Connor C, Sabbah HN, Metra M, Shah SJ, Kitzman DW, Teerlink JR, Bernstein HS, Brooks G, Depre C, DeSouza MM, Dinh W, Donovan M, Frische-Danielson R, Frost RJ, Garza D, Gohring UM, Hellawell J, Hsia J, Ishihara S, Kay-Mugford P, Koglin J, Kozinn M, Larson CJ, Mayo M, Gan LM, Mugnier P, Mushonga S, Roessig L, Russo C, Salsali A, Satler C, Shi V, Ticho B, van der Laan M, Yancy C, Stockbridge N, and Gheorghiade M. Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations Circ Heart Fail 2017; 10(4)PMID: 28356300. Full Text

Cheema BS, Sabbah HN, Greene SJ, and Gheorghiade M. Protein turnover in the failing heart: an ever-changing landscape Eur J Heart Fail 2017;PMID: 28805968. Full Text

Cho I, B OH, Gransar H, Valenti V, Lin FY, Achenbach S, Berman DS, Budoff MJ, Callister TQ, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Chow BJW, Dunning AM, DeLago A, Villines TC, Hadamitzky M, Hausleiter J, Leipsic J, Shaw LJ, Kaufmann PA, Cury RC, Feuchtner G, Kim YJ, Maffei E, Raff G, Pontone G, Andreini D, Chang HJ, and Min JK. Prognostic implications of coronary artery calcium in the absence of coronary artery luminal narrowing Atherosclerosis 2017; 262:185-190. PMID: 28385391. Full Text

Cowger JA, Stulak JM, Shah P, Dardas TF, Pagani FD, Dunlay SM, Maltais S, Aaronson KD, Singh R, Mokadam NA, Kirklin JK, and Salerno CT. Impact of center left ventricular assist device volume on outcomes after implantation: An INTERMACS analysis JACC Heart Fail 2017; 5(10):691-699. PMID: 28888521. Full Text

Daimee UA, Vermilye K, Rosero S, Schuger CD, Daubert JP, Zareba W, McNitt S, Polonsky B, Moss AJ, and Kutyifa V. Heart failure severity, inappropriate ICD therapy, and novel ICD Programming: A MADIT-RIT Sub-Study Pacing Clin Electrophysiol 2017;PMID: 29052236. Article Request Form

Danek BA, Karatasakis A, Tajti P, Sandoval Y, Karmpaliotis D, Alaswad K, Jaffer F, Yeh RW, Kandzari DE, Lembo NJ, Patel MP, Mahmud E, Choi JW, Doing AH, Lombardi WL, Wyman RM, Toma C, Garcia S, Moses JW, Kirtane AJ, Hatem R, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Khalili H, Burke MN, Banerjee S, and Brilakis ES. Incidence, treatment, and outcomes of coronary perforation during chronic total occlusion percutaneous coronary intervention Am J Cardiol 2017; 120(8):1285-1292. PMID: 28826896. Full Text

Daubert MA, Yow E, Dunn G, Marchev S, Barnhart H, Douglas PS, O'Connor C, Goldstein S, Udelson JE, and Sabbah HN. Novel mitochondria-targeting peptide in heart failure treatment: A randomized, placebo-controlled trial of elamipretide Circ Heart Fail 2017; 10(12)PMID: 29217757. Full Text

Deseive S, Shaw LJ, Min JK, Achenbach S, Andreini D, Al-Mallah MH, Berman DS, Budoff MJ, Callister TQ, Cademartiri F, Chang HJ, Chinnaiyan K, Chow BJ, Cury RC, DeLago A, Dunning AM, Feuchtner G, Kaufmann PA, Kim YJ, Leipsic J, Marques H, Maffei E, Pontone G, Raff G, Rubinshtein R, Villines TC, Hausleiter J, and Hadamitzky M. Improved 5-year prediction of all-cause mortality by coronary CT angiography applying the CONFIRM score Eur Heart J Cardiovasc Imaging 2017; 18(3):286-293. PMID: 28363203. Full Text

Ehrman JK, Brawner CA, Al-Mallah MH, Qureshi WT, Blaha MJ, and Keteyian SJ. Cardiorespiratory fitness change and mortality risk among black and white patients: Henry ford exercise testing (fit) project Am J Med 2017;PMID: 28344150. Full Text

Eng MH, Greenbaum A, Dee Wang D, Wyman J, Dnp, Arjomand H, Yadav P, Nemeh H, Paone G, Guerrero M, and O'Neill W. Thrombotic valvular dysfunction with transcatheter mitral interventions for postsurgical failures Catheter Cardiovasc Interv 2017;PMID: 28185392. Full text

Frisoli TM, Jain T, Swadia T, Hong X, and Guerrero M. Cardiac tamponade due to pyopneumopericardium from malignant bronchopericardial fistula Neth Heart J 2017;PMID: 28349347. Article Request Form

Frisoli TM, Afana M, Mawri S, Hadid M, Sayed L, O'Neill WW, Parikh S, Wang DD, Khandelwal A, and Alaswad K. Respect the septal perforator: Septal artery perforation during cto pci resulting in massive interventricular septal hematoma and biventricular cardiac obstructive shock JACC Cardiovasc Interv 2017;PMID: 28456700. Full Text

59 Frisoli TM, Nowak R, Evans KL, Harrison M, Alani M, Varghese S, Rahman M, Noll S, Flannery KR, Michaels A, Tabaku M, Jacobsen G, and McCord J. Henry Ford HEART score randomized trial: Rapid discharge of patients evaluated for possible myocardial infarction Circ Cardiovasc Qual Outcomes 2017; 10(10)PMID: 28954802. Full Text

Frisoli TM, Wang DD, Eng M, O'Neill WW, Paone G, and Greenbaum AB. Mitral annuloplasty ring fracture and annular injury during transcatheter mitral valve-in-ring intervention JACC Cardiovasc Interv 2017; 10(19):e181-e184. PMID: 28982567. Full Text

Greenbaum AB, and Frisoli TM. Surgical paravalvular leak closure: No more second chances JACC Cardiovasc Interv 2017; 10(5):508-509. PMID: 28279318. Full Text

Guerrero M, Wang DD, Himbert D, Urena M, Pursnani A, Kaddissi G, Iyer V, Salinger M, Chakravarty T, Greenbaum A, Makkar R, Vahanian A, Feldman T, and O'Neill W. Short-term results of alcohol septal ablation as a bail-out strategy to treat severe left ventricular outflow tract obstruction after transcatheter mitral valve replacement in patients with severe mitral annular calcification Catheter Cardiovasc Interv 2017;PMID: 28266162. Full Text

Hachey BJ, Kontos MC, Newby LK, Christenson RH, Peacock WF, Brewer KC, and McCord J. Trends in use of biomarker protocols for the evaluation of possible myocardial infarction J Am Heart Assoc 2017; 6(9)PMID: 28939707. Full Text

Hansen JW, Foy A, Yadav P, Gilchrist IC, Kozak M, Stebbins A, Matsouaka R, Vemulapalli S, Wang A, Wang DD, Eng MH, Greenbaum AB, and O'Neill WO. Death and dialysis after transcatheter aortic valve replacement: An analysis of the sts/acc tvt registry JACC Cardiovasc Interv 2017; 10(20):2064-2075. PMID: 29050623. Full Text

Held C, White HD, Stewart RAH, Budaj A, Cannon CP, Hochman JS, Koenig W, Siegbahn A, Steg PG, Soffer J, Weaver WD, Ostlund O, and Wallentin L. Inflammatory biomarkers interleukin-6 and c-reactive protein and outcomes in stable coronary heart disease: Experiences from the stability (stabilization of atherosclerotic plaque by initiation of darapladib therapy) trial J Am Heart Assoc 2017; 6(10)PMID: 29066452. Full Text

Kaatz S, Bhansali H, Gibbs J, Lavender R, Mahan CE, and Paje DG. Reversing factor Xa inhibitors - clinical utility of andexanet alfa J Blood Med 2017; 8:141-149. PMID: 28979172. Full Text

Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Lombardi W, Wyman MR, Doing A, Moses JW, Kirtane A, Parikh M, Ali Z, Kandzari D, Lembo N, Garcia S, Danek BA, Karatasakis A, Resendes E, Kalsaria P, Rangan BV, Ungi I, Thompson CA, Banerjee S, and Brilakis ES. Impact of calcium on chronic total occlusion percutaneous coronary interventions Am J Cardiol 2017;PMID: 28499595. Full Text

Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Doing A, Toma C, Uretsky B, Choi J, Moses JW, Kirtane A, Parikh M, Ali Z, Lombardi WL, Kandzari DE, Lembo N, Garcia S, Wyman MR, Martinez-Parachini JR, Karatasakis A, Danek BA, Alame AJ, Resendes E, Rangan BV, Ungi I, Thompson CA, Banerjee S, and Brilakis ES. The impact of proximal vessel tortuosity on the outcomes of chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry J Invasive Cardiol 2017; 29(8):264-270. PMID: 28570257. Request Article

Karatasakis A, Danek BA, Karmpaliotis D, Alaswad K, Vo M, Carlino M, Patel MP, Rinfret S, and Brilakis ES. Approach to CTO intervention: Overview of techniques Curr Treat Options Cardiovasc Med 2017; 19(1):1. PMID: 28105600. Full Text

Karatasakis A, Iwnetu R, Danek BA, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Kandzari DE, Lembo NJ, Patel M, Mahmud E, Lombardi WL, Wyman RM, Grantham JA, Doing AH, Toma C, Choi JW, Uretsky BF, Moses JW, Kirtane AJ, Ali ZA, Parikh M, Karacsonyi J, Rangan BV, Thompson CA, Banerjee S, and Brilakis ES. The impact of age and sex on in-hospital outcomes of chronic total occlusion percutaneous coronary intervention J Invasive Cardiol 2017; 29(4):116-122. PMID: 28089997 Full Text

Kianoush S, Al Rifai M, Cainzos-Achirica M, Al-Mallah MH, Tison GH, Yeboah J, Miedema MD, Allison MA, Wong ND, DeFilippis AP, Longstreth W, Nasir K, Budoff MJ, Matsushita K, and Blaha MJ. Thoracic extra-coronary calcification for the prediction of stroke: The Multi-Ethnic Study of Atherosclerosis Atherosclerosis 2017; 267:61- 67. PMID: 29100062. Full Text

Kolte D, Khera S, Sardar MR, Gheewala N, Gupta T, Chatterjee S, Goldsweig A, Aronow WS, Fonarow GC, Bhatt DL, Greenbaum AB, Gordon PC, Sharaf B, and Abbott JD. Thirty-day readmissions after transcatheter aortic valve replacement in the United States: Insights from the nationwide readmissions database Circ Cardiovasc Interv 2017; 10(1)PMID: 28034845. Full text

60 Kontos MC, Lanfear DE, Gosch K, Daugherty SL, Heidenriech P, and Spertus JA. Prognostic value of serial n- terminal pro-brain natriuretic peptide testing in patients with acute myocardial infarction Am J Cardiol 2017; 120(2):181-185. PMID: 28599802. Full Text

Kramer F, Sabbah HN, Januzzi JJ, Zannad F, Peter van Tintelen J, Schelbert EB, Kim RJ, Milting H, Vonk R, Neudeck B, Clark R, Witte K, Dinh W, Pieske B, Butler J, and Gheorghiade M. Redefining the role of biomarkers in heart failure trials: expert consensus document Heart Fail Rev 2017;PMID: 28332132. Full Text

Kruskall LJ, Manore MM, Eickhoff-Shemek JM, and Ehrman JK. DRAWING THE LINE Understanding the Scope of Practice Among Registered Dietitian Nutritionists and Exercise Professionals Acsms Health & Fitness Journal 2017; 21(1):23-32. PMID: Not assigned. Full Text

Kupsky DF, Ahmed AM, Sakr S, Qureshi WT, Brawner CA, Blaha MJ, Ehrman JK, Keteyian SJ, and Al-Mallah MH. Cardiorespiratory fitness and incident heart failure: The henry ford exercise testing (fit) project Am Heart J 2017; 185:35-42. PMID: 28267473. Full Text

Kusne S, Mooney M, Danziger-Isakov L, Kaan A, Lund LH, Lyster H, Wieselthaler G, Aslam S, Cagliostro B, Chen J, Combs P, Cochrane A, Conway J, Cowger J, Frigerio M, Gellatly R, Grossi P, Gustafsson F, Hannan M, Lorts A, Martin S, Pinney S, Silveira FP, Schubert S, Schueler S, Strueber M, Uriel N, Wrightson N, Zabner R, and Huprikar S. An ISHLT consensus document for prevention and management strategies for mechanical circulatory support infection J Heart Lung Transplant 2017;PMID: 28781010. Full Text

Kutyifa V, Beck C, Brown MW, Cannom D, Daubert J, Estes M, Greenberg H, Goldenberg I, Hammes S, Huang D, Klein H, Knops R, Kosiborod M, Poole J, Schuger C, Singh JP, Solomon S, Wilber D, Zareba W, and Moss AJ. Multicenter automatic defibrillator implantation trial-subcutaneous implantable cardioverter defibrillator (madit s-icd): Design and clinical protocol Am Heart J 2017; 189:158-166. PMID: 28625372. Full Text

Lanfear DE, Levy WC, Stehlik J, Estep JD, Rogers JG, Shah KB, Boyle AJ, Chuang J, Farrar DJ, and Starling RC. Accuracy of seattle heart failure model and heartmate ii risk score in non-inotrope-dependent advanced heart failure patients: Insights from the roadmap study (risk assessment and comparative effectiveness of left ventricular assist device and medical management in ambulatory heart failure patients) Circ Heart Fail 2017; 10(5)PMID: 28465311. Full Text

Lanfear DE, Gibbs JJ, Li J, She R, Petucci C, Culver JA, Tang WHW, Pinto YM, Williams LK, Sabbah HN, and Gardell SJ. Targeted metabolomic profiling of plasma and survival in heart failure patients JACC Heart Fail 2017; 5(11):823-832. PMID: 29096792. Full Text

Lavie CJ, Keteyian SJ, and Ventura HO. Therapeutic cardiorespiratory fitness to prevent and treat heart failure JACC Heart Fail 2017; 5(5):375-376. PMID: 28396039. Full Text

Lederman RJ, Greenbaum AB, Rogers T, Khan JM, Fusari M, and Chen MY. Anatomic suitability for transcaval access based on computed tomography JACC Cardiovasc Interv 2017; 10(1):1-10. PMID: 28057275. Full Text

Lin J, Chudasama N, Hayashi Y, Hawk C, Ramnauth SD, Wong KY, Harxhi A, Onat D, Wakabayashi M, Uriel N, Jorde UP, LeJemtel TH, Sabbah HN, Demmer RT, and Colombo PC. Peripheral venous congestion causes time- and dose-dependent release of endothelin-1 in humans Physiol Rep 2017; 5(6)PMID: 28320895. Full Text

Luo N, Merrill P, Parikh KS, Whellan DJ, Pina IL, Fiuzat M, Kraus WE, Kitzman DW, Keteyian SJ, O'Connor CM, and Mentz RJ. Exercise training in patients with chronic heart failure and atrial fibrillation J Am Coll Cardiol 2017; 69(13):1683-1691. PMID: 28359513. Full Text

McCord J, Cabrera R, Lindahl B, Giannitsis E, Evans K, Nowak R, Frisoli T, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, and Mueller C. Prognostic utility of a modified HEART score in chest pain patients in the emergency department Circ Cardiovasc Qual Outcomes 2017; 10(2)PMID: 28167641. Full text

Mendirichaga R, Singh V, Blumer V, Rivera M, Rodriguez AP, Cohen MG, O'Neill WW, and Elmariah S. Transcatheter mitral valve repair with mitraclip for symptomatic functional mitral valve regurgitation Am J Cardiol 2017;PMID: 28645469. Full Text

Meraj PM, Doshi R, Schreiber T, Maini B, and O'Neill WW. Impella 2.5 initiated prior to unprotected left main PCI in acute myocardial infarction complicated by cardiogenic shock improves early survival J Interv Cardiol 2017;PMID: 28419573. Full Text

61 Naoum C, Berman DS, Ahmadi A, Blanke P, Gransar H, Narula J, Shaw LJ, Kritharides L, Achenbach S, Al-Mallah MH, Andreini D, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow B, Cury RC, DeLago A, Dunning A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Maffei E, Marquez H, Pontone G, Raff G, Rubinshtein R, Villines TC, Min J, and Leipsic J. Predictive value of age- and sex-specific nomograms of global plaque burden on coronary computed tomography angiography for major cardiac events Circ Cardiovasc Imaging 2017; 10(3)PMID: 28292858. Full Text

Nowak R, Muller C, Giannitsis E, Christ M, Ordonez-Llanos J, DeFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Jacobsen G, Dinkel C, and Lindahl B. High sensitivity cardiac troponin t in patients not having an acute coronary syndrome: Results from the trapid-ami study Biomarkers 2017:1-26. PMID: 28532247. Article Request Form

O'Neal WT, Mazur M, Bertoni AG, Bluemke DA, Al-Mallah MH, Lima JAC, Kitzman D, and Soliman EZ. Electrocardiographic predictors of heart failure with reduced versus preserved ejection fraction: The multi-ethnic study of atherosclerosis J Am Heart Assoc 2017; 6(6)PMID: 28546456. Full Text

O'Neill W, Basir M, Dixon S, Patel K, Schreiber T, and Almany S. Feasibility of early mechanical support during mechanical reperfusion of acute myocardial infarct cardiogenic shock JACC Cardiovasc Interv 2017; 10(6):624-625. PMID: 28335901. Full Text

Parsh J, Seth M, Green J, Sutton NR, Chetcuti S, Dixon S, Grossman PM, Khandelwal A, Dupree JM, and Gurm HS. Coronary artery perforations after contemporary percutaneous coronary interventions: Evaluation of incidence, risk factors, outcomes, and predictors of mortality Catheter Cardiovasc Interv 2017;PMID: 28145612. Full Text

Patsias I, Swanson B, Hudson M, Parikh S, Nour K, Jacobsen G, and McCord J. The (dis) utility of a change in troponin i for diagnosis of non-st-segment elevation myocardial infarction in an observation unit Crit Pathw Cardiol 2017; 16(3):105-108. PMID: 28742647. Full Text

Perini AP, Kutyifa V, Veazie P, Daubert JP, Schuger C, Zareba W, McNitt S, Rosero S, Tompkins C, Padeletti L, and Moss AJ. Effects of implantable cardioverter/defibrillator shock and antitachycardia pacing on anxiety and quality of life: A MADIT-RIT substudy Am Heart J 2017; 189:75-84. PMID: 28625384. Full Text

Sabbah HN. Pathophysiology of acute heart failure syndrome: a knowledge gap Heart Fail Rev 2017;PMID: 28952056. Full Text

Sakr S, Elshawi R, Ahmed AM, Qureshi WT, Brawner CA, Keteyian SJ, Blaha MJ, and Al-Mallah MH. Comparison of machine learning techniques to predict all-cause mortality using fitness data: the Henry ford exercIse testing (FIT) project BMC Med Inform Decis Mak 2017; 17(1):174. PMID: 29258510. Full Text

Same RV, Al Rifai M, Feldman DI, Billups KL, Brawner CA, Dardari ZA, Ehrman JK, Keteyian SJ, Al-Mallah MH, and Blaha MJ. Prognostic value of exercise capacity among men undergoing pharmacologic treatment for erectile dysfunction: The FIT Project Clin Cardiol 2017;PMID: 28805967. Full Text

Schelbert EB, Sabbah HN, Butler J, and Gheorghiade M. Employing extracellular volume cardiovascular magnetic resonance measures of myocardial fibrosis to foster novel therapeutics Circ Cardiovasc Imaging 2017; 10(6)PMID: 28512159. Full Text

Shaya GE, Juraschek SP, Feldman DI, Brawner CA, Ehrman JK, Keteyian SJ, Al-Mallah MH, and Blaha MJ. Relation of exercise capacity to risk of development of diabetes in patients on statin therapy (the henry ford exercise testing project) Am J Cardiol 2017;PMID: 28716336. Full Text

Singh V, Rodriguez AP, Bhatt P, Alfonso CE, Sakhuja R, Palacios IF, Inglessis-Azuaje I, Cohen MG, Elmariah S, and O'Neill WW. Ventricular septal defect complicating st-elevation myocardial infarctions: A call for action Am J Med 2017;PMID: 28065768. Full Text

Singh G, Lahiri MK, Khan A, and Schuger CD. Bundle branch reentrant ventricular tachycardia after transcatheter aortic valve replacement HeartRhythm Case Rep 2017; 3(3):177-185. PMID: 28491797. Full Text

Singh V, Yadav PK, Eng MH, Macedo FY, Silva GV, Mendirichaga R, Badiye AP, Sakhuja R, Elmariah S, Inglessis I, Alfonso CE, Schreiber TL, Cohen M, Palacios I, and O'Neill WW. Outcomes of hemodynamic support with Impella in very high-risk patients undergoing balloon aortic valvuloplasty: Results from the Global cVAD Registry Int J Cardiol 2017;PMID: 28377189. Full Text

62 Song C, Sukul D, Seth M, Dupree JM, Khandelwal A, Dixon SR, Wohns D, LaLonde T, and Gurm HS. Ninety-day readmission and long-term mortality in medicare patients (>/=65 years) treated with ticagrelor versus prasugrel after percutaneous coronary intervention (from the blue cross blue shield of michigan cardiovascular consortium) Am J Cardiol 2017;PMID: 29025684. Full Text

Sukul D, Seth M, Schreiber T, Khandelwal A, Cannon LA, LaLonde TA, and Gurm HS. The comparative safety and effectiveness of bivalirudin versus heparin monotherapy in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan cardiovascular consortium Catheter Cardiovasc Interv 2017;PMID: 28303632. Full Text

Sukul D, Seth M, Schreiber T, Hanzel G, Khandelwal A, Cannon LA, Lalonde TA, and Gurm HS. The comparative safety of abciximab versus eptifibatide in patients on dialysis undergoing percutaneous coronary intervention: Insights from the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) J Interv Cardiol 2017;PMID: 28543770. Full Text

Sukul D, Seth M, Dixon SR, Khandelwal A, LaLonde TA, and Gurm HS. Contemporary trends and outcomes associated with the preprocedural use of oral p2y12 inhibitors in patients undergoing percutaneous coronary intervention: Insights from the blue cross blue shield of michigan cardiovascular consortium (BMC2) J Invasive Cardiol 2017; 29(10):340-351. PMID: 28420804. Full Text

Thomas GS, Cullom SJ, Kitt TM, Feaheny KM, Ananthasubramaniam K, Gropler RJ, Jain D, and Thompson RC. The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol J Nucl Cardiol 2017;PMID: 28224449. Article request form

Tita C, Gilbert EM, Van Bakel AB, Grzybowski J, Haas GJ, Jarrah M, Dunlap SH, Gottlieb SS, Klapholz M, Patel PC, Pfister R, Seidler T, Shah KB, Zielinski T, Venuti RP, Cowart D, Foo SY, Vishnevsky A, and Mitrovic V. A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction Eur J Heart Fail 2017;PMID: 28677877. Full Text van Bilsen M, Patel HC, Bauersachs J, Bohm M, Borggrefe M, Brutsaert D, Coats AJS, de Boer RA, de Keulenaer GW, Filippatos GS, Floras J, Grassi G, Jankowska EA, Kornet L, Lunde IG, Maack C, Mahfoud F, Pollesello P, Ponikowski P, Ruschitzka F, Sabbah HN, Schultz HD, Seferovic P, Slart R, Taggart P, Tocchetti CG, Van Laake LW, Zannad F, Heymans S, and Lyon AR. The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail 2017;PMID: 28949064. Full Text

Xie JX, Eshtehardi P, Varghese T, Goyal A, Mehta PK, Kang W, Leipsic J, B OH, Bairey Merz CN, Berman DS, Gransar H, Budoff MJ, Achenbach S, Callister TQ, Marques H, Rubinshtein R, Al-Mallah MH, Andreini D, Pontone G, Cademartiri F, Maffei E, Chinnaiyan K, Raff G, Hadamitzky M, Hausleiter J, Feuchtner G, Kaufmann PA, Villines TC, Chow BJW, Min JK, and Shaw LJ. Prognostic significance of nonobstructive left main coronary artery disease in women versus men: Long-term outcomes from the confirm (coronary ct angiography evaluation for clinical outcomes: An international multicenter) registry Circ Cardiovasc Imaging 2017; 10(8)PMID: 28790123. Full Text

Yadav P, and Eng MH. Power of gradients Catheter Cardiovasc Interv 2017; 90(7):1183-1184. PMID: 29226573. Full Text

Endocrinology and Metabolism

Aleppo G, Ruedy KJ, Riddlesworth TD, Kruger DF, Peters AL, Hirsch I, Bergenstal RM, Toschi E, Ahmann AJ, Shah VN, Rickels MR, Bode BW, Philis-Tsimikas A, Pop-Busui R, Rodriguez H, Eyth E, Bhargava A, Kollman C, and Beck RW. REPLACE-BG: A randomized trial comparing continuous glucose monitoring with and without routine blood glucose monitoring in well-controlled adults with type 1 diabetes Diabetes Care 2017;PMID: 28209654. Full text

Arya AK, Bhadada SK, Singh P, Sachdeva N, Saikia UN, Dahiya D, Behera A, Bhansali A, and Rao SD. Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas Sci Rep 2017; 7(1):3123. PMID: 28600574. Full Text

63 Beck RW, Riddlesworth T, Ruedy K, Ahmann A, Bergenstal R, Haller S, Kollman C, Kruger D, McGill JB, Polonsky W, Toschi E, Wolpert H, and Price D. Effect of continuous glucose monitoring on glycemic control in adults with type 1 diabetes using insulin injections: The diamond randomized clinical trial Jama 2017; 317(4):371-378. PMID: 28118453. Full Text

Beck RW, Riddlesworth TD, Ruedy KJ, Kollman C, Ahmann AJ, Bergenstal RM, Bhargava A, Bode BW, Haller S, Kruger DF, McGill JB, Polonsky W, Price D, and Toschi E. Effect of initiating use of an insulin pump in adults with type 1 diabetes using multiple daily insulin injections and continuous glucose monitoring (DIAMOND): a multicentre, randomised controlled trial Lancet Diabetes Endocrinol 2017;PMID: 28711468. Full Text

Beck RW, Riddlesworth TD, Ruedy K, Ahmann A, Haller S, Kruger D, McGill JB, Polonsky W, Price D, Aronoff S, Aronson R, Toschi E, Kollman C, and Bergenstal R. Continuous glucose monitoring versus usual care in patients with type 2 diabetes receiving multiple daily insulin injections: A randomized trial Ann Intern Med 2017; 167(6):365- 374. PMID: 28828487. Full Text

Bergen PM, Kruger DF, Taylor AD, Eid WE, Bhan A, and Jackson JA. Translating u-500r randomized clinical trial evidence to the practice setting: A diabetes educator/expert prescriber team approach Diabetes Educ 2017:145721717701579. PMID: 28427304. Full Text

Bergenstal RM, Gal RL, Connor CG, Gubitosi-Klug R, Kruger D, Olson BA, Willi SM, Aleppo G, Weinstock RS, Wood J, Rickels M, DiMeglio LA, Bethin KE, Marcovina S, Tassopoulos A, Lee S, Massaro E, Bzdick S, Ichihara B, Markmann E, McGuigan P, Woerner S, Ecker M, and Beck RW. Racial differences in the relationship of glucose concentrations and hemoglobin a1c levels Ann Intern Med 2017;PMID: 28605777. Full Text

Bhadada SK, Dhiman V, Mukherjee S, Aggarwal S, Bal A, Sukumar SP, Sood A, Sharma DC, Khandelwal N, Bhansali A, Van Hul W, and Rao SD. Fibrogenesis imperfecta ossium and response to human growth hormone: A potential novel therapy J Clin Endocrinol Metab 2017;PMID: 28323922. Full Text

Gopalaswamy V, Dhibar DP, Gupta V, Arya AK, Khandelwal N, Bhansali A, Garg SK, Agarwal N, Rao SD, and Bhadada SK. Anabolic bone window with weekly teriparatide therapy in post menopausal osteoporosis: A pilot study Endocr Pract 2017;PMID: 28225309. Article request form

Handa R, and Rahman A. Ectopic ACTH syndrome from metastatic pancreatic neuroendocrine tumor Consultant 2017; 57(8)PMID: Not assigned. Request Article

Lahiri SW. Personalizing type 2 diabetes management: Use of a patient-centered approach to individualizing a1c goals and pharmacological regimens Clin Diabetes 2017; 35(5):321-328. PMID: 29263575. Article Request Form

Novak LM, and Kruger DF. Bolstering your armamentarium with SGLT2 inhibitors Nurse Pract 2017; 42(10):28- 34. PMID: 28926495. Full Text

Pathak RD, Schroeder EB, Seaquist ER, Zeng C, Lafata JE, Thomas A, Lawrence JM, Karter AJ, Steiner JF, Segal J, and O'Connor PJ. Response to comment on pathak et al. Severe hypoglycemia requiring medical intervention in a large cohort of adults with diabetes receiving care in u.S. Integrated health care delivery systems: 2005-2011. Diabetes care 2016;39:363-370 Diabetes Care 2017; 40(2):e26. PMID: 28108542. Full Text

Rao SD, Qiu S, Dhaliwal R, and Bhadada SK. Letter to the editor: Severe rebound-associated vertebral fractures after denosumab discontinuation J Clin Endocrinol Metab 2017; 102(6):2111. PMID: 28586451. Full Text Full Text

Sharma S, Rastogi A, Bhadada SK, Singh P, Varshney S, Behera A, Bhansali A, Singh SK, and Rao DS. Prevalence and predictors of primary hyperparathyroidism amongpatients with urolithiasis Endocr Pract 2017;PMID: 28816531. Request Article

Strong J, Kruger D, and Novak L. Insulin glargine 300 units/mL: a guide for healthcare professionals involved in the management of diabetes Curr Med Res Opin 2017:1-19. PMID: 28132529. Article Request Form

Sundaram K, Sambandam Y, Shanmugarajan S, Rao DS, and Reddy SV. Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-beta1 (SIRPbeta1) to enhance osteoclast differentiation in Paget's disease of bone Bone Rep 2017; 7:26-32. PMID: 28840181. Full Text

Thanseer N, Bhadada SK, Sood A, Mittal BR, Behera A, Gorla AKR, Kalathoorakathu RR, Singh P, Dahiya D, Saikia UN, and Rao SD. Comparative effectiveness of ultrasonography, 99mtc-sestamibi, and 18f-fluorocholine pet/ct in detecting parathyroid adenomas in patients with primary hyperparathyroidism Clin Nucl Med 2017;PMID: 28902729. Full Text

64 Ye T, Cao P, Qi J, Zhou Q, Rao DS, and Qiu S. Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats PLoS One 2017; 12(10):e0186012. PMID: 29045447. Full Text

Gastroenterology

Abu Ghanimeh M, Qasrawi A, Abughanimeh O, Albadarin S, and Clarkston W. Achalasia after bariatric Roux-en- Y gastric bypass surgery reversal World J Gastroenterol 2017; 23(37):6902-6906. PMID: 29085233. Full Text

Arnautovic JZ, Mazhar A, Tereziu S, and Gupta K. A rare association of congenital asplenia with jejunal arteriovenous malformation Am J Case Rep 2017; 18:1118-1122. PMID: 29046517. Full Text

Boscarino JA, Moorman AC, Rupp LB, Zhou Y, Lu M, Teshale EH, Gordon SC, Spradling PR, Schmidt MA, Trinacty CM, Zhong Y, Holmberg SD, and Holtzman D. Comparison of icd-9 codes for depression and alcohol misuse to survey instruments suggests these codes should be used with caution Dig Dis Sci 2017; 62(10):2704- 2712. PMID: 28879547. Full Text

Bourliere M, Gordon SC, Flamm SL, Cooper CL, Ramji A, Tong M, Ravendhran N, Vierling JM, Tran TT, Pianko S, Bansal MB, de Ledinghen V, Hyland RH, Stamm LM, Dvory-Sobol H, Svarovskaia E, Zhang J, Huang KC, Subramanian GM, Brainard DM, McHutchison JG, Verna EC, Buggisch P, Landis CS, Younes ZH, Curry MP, Strasser SI, Schiff ER, Reddy KR, Manns MP, Kowdley KV, and Zeuzem S. Sofosbuvir, velpatasvir, and voxilaprevir for previously treated hcv infection N Engl J Med 2017; 376(22):2134-2146. PMID: 28564569. Full Text

Brown K. Maximizing donors with viral hepatitis in the current era Liver Transpl 2017; 23(S1):S44-s49. PMID: 28846183. Full Text

DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, and Channick RN. Predictors of waitlist mortality in portopulmonary hypertension Transplantation 2017;PMID: 28207639. Full text

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouilleres O, Farkkila M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D, Yu L, Bowlus CL, Franke A, Lie BA, and Karlsen TH. HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry Hla 2017;PMID: 28695657. Full Text

Iqbal U, Chaudhary A, Karim MA, Siddiqui MA, Anwar H, and Merrell N. Association of autoimmune hepatitis and celiac disease: Role of gluten-free diet in reversing liver dysfunction J Investig Med High Impact Case Rep 2017; 5(2):2324709617705679. PMID: 28491884. Full Text

Jinjuvadia R, Salami A, Lenhart A, Jinjuvadia K, Liangpunsakul S, and Salgia R. Hepatocellular carcinoma: A decade of hospitalizations and financial burden in the United States Am J Med Sci 2017; 354(4):362-369. PMID: 29078840. Full Text

Jones D, Boudes PF, Swain MG, Bowlus CL, Galambos MR, Bacon BR, Doerffel Y, Gitlin N, Gordon SC, Odin JA, Sheridan D, Worns MA, Clark V, Corless L, Hartmann H, Jonas ME, Kremer AE, Mells GF, Buggisch P, Freilich BL, Levy C, Vierling JM, Bernstein DE, Hartleb M, Janczewska E, Rochling F, Shah H, Shiffman ML, Smith JH, Choi YJ, Steinberg A, Varga M, Chera H, Martin R, McWherter CA, and Hirschfield GM. Seladelpar (MBX-8025), a selective PPAR-delta agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study Lancet Gastroenterol Hepatol 2017;PMID: 28818518. Request Article

Kanwal F, Bacon BR, Beste LA, Brill JV, Gifford AL, Gordon SC, Horberg MA, Manthey JG, Reau N, Rustgi VK, and Younossi ZM. Hepatitis c virus infection care pathway-a report from the american gastroenterological association institute hcv care pathway work group Gastroenterology 2017; 152(6):1588-1598. PMID: 28442121. Full Text

Kwo PY, Poordad F, Asatryan A, Wang S, Wyles DL, Hassanein T, Felizarta F, Sulkowski MS, Gane E, Maliakkal B, Scott Overcash J, Gordon SC, Muir AJ, Aguilar H, Agarwal K, Dore GJ, Lin CW, Liu R, Lovell SS, Ng TI, Kort J, and Mensa FJ. Glecaprevir and Pibrentasvir Yield High response Rates in Patients with HCV Genotype 1-6 without Cirrhosis J Hepatol 2017;PMID: 28412293. Full Text

Lenhart A, and Chey WD. A systematic review of the effects of polyols on gastrointestinal health and irritable bowel syndrome Adv Nutr 2017; 8(4):587-596. PMID: 28710145. Request Article

65 Lenhart A, Meighani A, Hassan M, and Gordon S. Hepatitis c virus-associated aortitis caused by type I cryoglobulins ACG Case Rep J 2017; 4:e114. PMID: 29090238. Full Text

Lu M, Chacra W, Rabin D, Rupp LB, Trudeau S, Li J, and Gordon SC. Validity of an automated algorithm using diagnosis and procedure codes to identify decompensated cirrhosis using electronic health records Clin Epidemiol 2017; 9:369-376. PMID: 28744162. Full Text

Meighani A, Hart BR, Bourgi K, Miller N, John A, and Ramesh M. Outcomes of fecal microbiota transplantation for clostridium difficile infection in patients with inflammatory bowel disease Dig Dis Sci 2017;PMID: 28451916. Full Text

Piraka C, Saeed A, Waljee AK, Pillai A, Stidham R, and Elmunzer BJ. Cold snare polypectomy for non- pedunculated colon polyps greater than 1 cm Endosc Int Open 2017; 5(3):E184-e189. PMID: 28331902. Full Text

Poordad F, Felizarta F, Asatryan A, Sulkowski MS, Reindollar RW, Landis CS, Gordon SC, Flamm SL, Fried MW, Bernstein DE, Lin CW, Liu R, Lovell SS, Ng TI, Kort J, and Mensa FJ. Glecaprevir and pibrentasvir for 12 weeks for hcv genotype 1 infection and prior direct-acting antiviral treatment Hepatology 2017;PMID: 28128852. Full Text

Safwan M, Collins KM, Abouljoud MS, and Salgia R. Outcome of liver transplantation in patients with prior bariatric surgery Liver Transpl 2017;PMID: 28752920. Full Text

Tavakkoli A, Law RJ, Bedi AO, Prabhu A, Hiatt T, Anderson MA, Wamsteker EJ, Elmunzer BJ, Piraka CR, Scheiman JM, Elta GH, and Kwon RS. Specialist endoscopists are associated with a decreased risk of incomplete polyp resection during endoscopic mucosal resection in the colon Dig Dis Sci 2017;PMID: 28600656. Full Text

Terrault NA, Berenguer M, Strasser SI, Gadano A, Lilly L, Samuel D, Kwo PY, Agarwal K, Curry MP, Fagiuoli S, Fung JYY, Gane E, Brown KA, Burra P, Charlton M, Pessoa MG, and McCaughan GW. International liver transplantation society consensus statement on hepatitis c management in liver transplant recipients Transplantation 2017; 101(5):956-967. PMID: 28437388. Full Text

Terrault NA, McCaughan GW, Curry MP, Gane E, Fagiuoli S, Fung JYY, Agarwal K, Lilly L, Strasser SI, Brown KA, Gadano A, Kwo PY, Burra P, Samuel D, Charlton M, Pessoa MG, and Berenguer M. International liver transplantation society consensus statement on hepatitis c management in liver transplant candidates Transplantation 2017; 101(5):945-955. PMID: 28437387. Full Text

Wani S, Keswani R, Hall M, Han S, Ali MA, Brauer B, Carlin L, Chak A, Collins D, Cote GA, Diehl DL, DiMaio CJ, Dries A, El-Hajj I, Ellert S, Fairley K, Faulx A, Fujii-Lau L, Gaddam S, Gan SI, Gaspar JP, Gautamy C, Gordon S, Harris C, Hyder S, Jones R, Kim S, Komanduri S, Law R, Lee L, Mounzer R, Mullady D, Muthusamy VR, Olyaee M, Pfau P, Saligram S, Piraka C, Rastogi A, Rosenkranz L, Rzouq F, Saxena A, Shah RJ, Simon VC, Small A, Sreenarasimhaiah J, Walker A, Wang AY, Watson RR, Wilson RH, Yachimski P, Yang D, Edmundowicz S, and Early DS. A prospective multicenter study evaluating learning curves and competence in endoscopic ultrasound and endoscopic retrograde cholangiopancreatography among advanced endoscopy trainees: The rapid assessment of trainee endoscopy skills (rates) study Clin Gastroenterol Hepatol 2017;PMID: 28625816. Full Text

Xing J, Spradling PR, Moorman AC, Holmberg SD, Teshale EH, Rupp LB, Gordon SC, Lu M, Boscarino JA, Schmidt MA, Trinacty CM, and Xu F. A point system to forecast hepatocellular carcinoma risk before and after treatment among persons with chronic hepatitis c Dig Dis Sci 2017; 62(11):3221-3234. PMID: 28965221. Full Text

Younossi Z, Gordon SC, Ahmed A, Dieterich D, Saab S, and Beckerman R. Treating Medicaid patients with hepatitis C: clinical and economic impact Am J Manag Care 2017; 23(2):107-112. PMID: 28245654. Full Text

Younossi ZM, Stepanova M, Gordon S, Zeuzem S, Mann MP, Jacobson I, Bourliere M, Cooper C, Flamm S, Reddy KR, Kowdley K, Younossi I, and Hunt S. Patient-reported outcomes following treatment of chronic hepatitis c virus infection with sofosbuvir and velpatasvir, with or without voxilaprevir Clin Gastroenterol Hepatol 2017;PMID: 29155352. Full Text

Hematology-Oncology

Alford SH, Divine G, Chao C, Habel LA, Janakiraman N, Wang Y, Feigelson HS, Scholes D, Roblin D, Epstein MM, Engel L, Havstad S, Wells K, Yood MU, Fortuny J, and Johnson CC. Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis Cancer Causes Control 2017;PMID: 29192350. Full Text

66 Apolo AB, Infante JR, Balmanoukian A, Patel MR, Wang D, Kelly K, Mega AE, Britten CD, Ravaud A, Mita AC, Safran H, Stinchcombe TE, Srdanov M, Gelb AB, Schlichting M, Chin K, and Gulley JL. Avelumab, an anti- programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: Results from a multicenter, phase ib study J Clin Oncol 2017:Jco2016716795. PMID: 28375787. Full Text

Bendell JC, Javle M, Bekaii-Saab TS, Finn RS, Wainberg ZA, Laheru DA, Weekes CD, Tan BR, Khan GN, Zalupski MM, Infante JR, Jones S, Papadopoulos KP, Tolcher AW, Chavira RE, Christy-Bittel JL, Barrett E, and Patnaik A. A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor Br J Cancer 2017;PMID: 28152546. Full Text

Berry LL, Danaher TS, Chapman RA, and Awdish RLA. Role of kindness in cancer care J Oncol Pract 2017:Jop2017026195. PMID: 29035616. Full Text

Carruthers NJ, Stemmer PM, Chen B, Valeriote F, Gao X, Guatam SC, and Shaw J. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation Eur J Pharmacol 2017;PMID: 28576409. Article Request Form

Deeb D, Gao X, Bo Liu Y, Zhang Y, Shaw J, Valeriote FA, and Gautam SC. Inhibition of hTERT in pancreatic cancer cells by pristimerin involves suppression of epigenetic regulators of gene transcription Oncology Reports 2017; 37(3):1914-1920. PMID: Not yet assigned. Article request form

Garcia-Manero G, Montalban-Bravo G, Berdeja JG, Abaza Y, Jabbour E, Essell J, Lyons RM, Ravandi F, Maris M, Heller B, DeZern AE, Babu S, Wright D, Anz B, Boccia R, Komrokji RS, Kuriakose P, Reeves J, Sekeres MA, Kantarjian HM, Ghalie R, and Roboz GJ. Phase 2, randomized, double-blind study of pracinostat in combination with azacitidine in patients with untreated, higher-risk myelodysplastic syndromes Cancer 2017; 123(6):994-1002. PMID: 28094841. Full Text

Gulley JL, Rajan A, Spigel DR, Iannotti N, Chandler J, Wong DJ, Leach J, Edenfield WJ, Wang D, Grote HJ, Heydebreck AV, Chin K, Cuillerot JM, and Kelly K. Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN Solid Tumor): dose-expansion cohort of a multicentre, open- label, phase 1b trial Lancet Oncol 2017;PMID: 28373005. Full Text

Kahlon PS, Mishra A, Williams TR, Sandhu NK, Donthireddy V, and Dobrostoskaya I. Diagnosing primary squamous cell cancer of the rectum in a patient with hiv: A case report J Oncol Pract 2017:Jop2016019901. PMID: 28557660. Article Request Form

Lambing A, Nichols CD, Munn JE, Anderson TL, Tortella BJ, and Witkop ML. Patient, caregiver, and provider perceptions of pain and pain management in adolescents and young adults with bleeding disorders Haemophilia 2017; 23(6):852-860. PMID: 28806860. Full Text

Lin S, McCauley EP, Lorig-Roach N, Tenney K, Naphen CN, Yang AM, Johnson TA, Hernadez T, Rattan R, Valeriote FA, and Crews P. Another look at pyrroloiminoquinone alkaloids-perspectives on their therapeutic potential from known structures and semisynthetic analogues Mar Drugs 2017; 15(4)PMID: 28353633. Full Text

Liquete E, Williamson SR, Janakiraman N, and Venkat KK. Renal complications of hematopoietic stem cell transplantation: Report of a case and review of the literature Indian J Nephrol 2017; 27(6):468-471. PMID: 29217887. Full Text

Lourenco AP, Benson KL, Henderson MC, Silver M, Letsios E, Tran Q, Gordon KJ, Borman S, Corn C, Mulpuri R, Smith W, Alpers J, Costantini C, Rohatgi N, Yang R, Ali H, Shah B, Morris M, Kass F, and Reese DE. A noninvasive blood-based combinatorial proteomic biomarker assay to detect breast cancer in women under the age of 50 years Clin Breast Cancer 2017;PMID: 28624156. Full Text

McCauley EP, Lam H, Lorig-Roach N, Luu J, Lloyd C, Tenney K, Pietraszkiewicz H, Diaz C, Valeriote FA, Auerbuch V, and Crews P. Investigation of the physical and bioactive properties of bromo- and iodo- containing sponge-derived compounds possessing an oxyphenylethanamine core J Nat Prod 2017;PMID: 29144750. Article Request Form

McLaughlin JM, Munn JE, Anderson TL, Lambing A, Tortella B, and Witkop ML. Predictors of quality of life among adolescents and young adults with a bleeding disorder Health Qual Life Outcomes 2017; 15(1):67. PMID: 28388906. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383972/

67 Muffly L, Pasquini MC, Martens M, Brazauskas R, Zhu X, Adekola K, Aljurf M, Ballen KK, Bajel A, Baron F, Battiwalla M, Beitinjaneh A, Cahn JY, Carabasi M, Chen YB, Chhabra S, Ciurea S, Copelan E, D'Souza A, Edwards J, Foran J, Freytes CO, Fung HC, Gale RP, Giralt S, Hashmi SK, Hildebrandt GC, Ho V, Jakubowski A, Lazarus H, Luskin MR, Martino R, Maziarz R, McCarthy P, Nishihori T, Olin R, Olsson RF, Pawarode A, Peres E, Rezvani AR, Rizzieri D, Savani BN, Schouten HC, Sabloff M, Seftel M, Seo S, Sorror ML, Szer J, Wirk BM, Wood WA, and Artz A. Increasing use of allogeneic hematopoietic cell transplantation in patients age 70 years and older in the United States Blood 2017;PMID: 28674027. Full Text

Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, and Gerwick WH. Integrating molecular networking and biological assays to target the isolation of a cytotoxic cyclic octapeptide, samoamide a, from an american samoan marine cyanobacterium J Nat Prod 2017; 80(3):625-633. PMID: 28055219. Article Request Form

Patel MR, Ellerton J, Infante JR, Agrawal M, Gordon M, Aljumaily R, Britten CD, Dirix L, Lee KW, Taylor M, Schoffski P, Wang D, Ravaud A, Gelb AB, Xiong J, Rosen G, Gulley JL, and Apolo AB. Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open- label, phase 1 trial Lancet Oncol 2017;PMID: 29217288. Full Text

Pilling AB, Hwang O, Boudreault A, Laurent A, and Hwang C. Iap antagonists enhance apoptotic response to enzalutamide in castration-resistant prostate cancer cells via autocrine tnf-alpha signaling Prostate 2017;PMID: 28240376. Full text

Schlumberger M, Elisei R, Muller S, Schoffski P, Brose M, Shah M, Licitra L, Krajewska J, Kreissl MC, Niederle B, Cohen EEW, Wirth L, Ali H, Clary DO, Yaron Y, Mangeshkar M, Ball D, Nelkin B, and Sherman S. Overall survival analysis of EXAM, a phase 3 trial of cabozantinib in patients with radiographically progressive medullary thyroid carcinoma Ann Oncol 2017;PMID: 29045520. Full Text

Thamilselvan V, Menon M, Stein GS, Valeriote F, and Thamilselvan S. Combination of carmustine and selenite Inhibits EGFR mediated growth signaling in androgen-independent prostate cancer cells J Cell Biochem 2017;PMID: 28430389. Full Text

Varadarajan I, Basu A, Besmer S, Poli J, Richard S, and Styler M. Solitary skeletal muscle metastasis as first site of recurrence of cervical cancer: A case report Case Rep Oncol 2017; 10(2):694-698. PMID: 28878652. Full Text

Zhang H, Crews P, Tenney K, and Valeriote FA. Cytotoxic phyllactone analogs from the marine sponge phyllospongia papyrecea Med Chem 2017; 13(3):295-300. PMID: 27748180. Full Text

Hypertension and Vascular Research

Cerniello FM, Carretero OA, Longo Carbajosa NA, Cerrato BD, Santos RA, Grecco HE, and Gironacci MM. Mas1 receptor trafficking involves erk1/2 activation through a beta-arrestin2-dependent pathway Hypertension 2017; 70(5):982-989. PMID: 28874464. Full Text

Chen J, Cui C, Yang X, Xu J, Venkat P, Zacharek A, Yu P, and Chopp M. Mir-126 affects brain-heart interaction after cerebral ischemic stroke Transl Stroke Res 2017;PMID: 28101763. Article Request Form

Gordish KL, Kassem KM, Ortiz PA, and Beierwaltes WH. Moderate (20%) fructose-enriched diet stimulates salt- sensitive hypertension with increased salt retention and decreased renal nitric oxide Physiol Rep 2017; 5(7)PMID: 28408634. Full Text

Karuppagounder V, Arumugam S, Giridharan VV, Sreedhar R, Bose RJ, Vanama J, Palaniyandi SS, Konishi T, Watanabe K, and Thandavarayan RA. Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy Nutrition 2017; 34:47-54. PMID: 28063511. Full Text

Nakagawa P, Masjoan-Juncos JX, Basha H, Janic B, Worou ME, Liao TD, Romero CA, Peterson EL, and Carretero OA. Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus Physiol Rep 2017; 5(2)PMID: 28126732. Full Text

Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, and Staruschenko A. Lack of effects of metformin and aicar chronic infusion on the development of hypertension in dahl salt-sensitive rats Front Physiol 2017; 8:227. PMID: 28473772. Full Text

68 Rhoads MK, Goleva SB, Beierwaltes WH, and Osborn JL. Renal vascular and glomerular pathologies associated with spontaneous hypertension in the nonhuman primate Chlorocebus aethiops sabaeus Am J Physiol Regul Integr Comp Physiol 2017; 313(3):R211-r218. PMID: 28659284. Full Text

Wang H, Romero CA, Masjoan Juncos JX, Monu SR, Peterson EL, and Carretero OA. Effect of salt intake on afferent arteriolar dilatation: Role of connecting tubule glomerular feedback (CTGF) Am J Physiol Renal Physiol 2017:ajprenal.00320.02017. PMID: 28835421. Full Text

Infectious Diseases

Arshad S, Huang V, Hartman P, Perri MB, Moreno D, and Zervos MJ. Ceftaroline fosamil monotherapy for methicillin-resistant Staphylococcus aureus bacteremia (MRSAB): A comparative clinical outcomes study Int J Infect Dis 2017;PMID: 28131729. Full Text

Ayau P, Bardossy AC, Sanchez G, Ortiz R, Moreno D, Hartman P, Rizvi K, Prentiss TC, Perri MB, Mahan M, Huang V, Reyes K, and Zervos MJ. Risk factors for 30-day mortality in patients with methicillin-resistant staphylococcus aureus bloodstream infections Int J Infect Dis 2017;PMID: 28533166. Full Text

Bardossy AC, Alsafadi MY, Starr P, Chami E, Pietsch J, Moreno D, Johnson L, Alangaden G, Zervos M, and Reyes K. Evaluation of contact precautions for methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus Am J Infect Control 2017;PMID: 28843943. Full Text

Bourgi K, Patel J, Samuel L, Kieca A, Johnson L, and Alangaden G. Clinical impact of nucleic acid amplification testing in the diagnosis of mycobacterium tuberculosis: A 10-year longitudinal study Open Forum Infect Dis 2017; 4(2):ofx045. PMID: 28470022. Full Text

Flynt LK, Kenney RM, Zervos MJ, and Davis SL. The safety and economic impact of cefazolin versus nafcillin for the treatment of methicillin-susceptible staphylococcus aureus bloodstream infections Infect Dis Ther 2017;PMID: 28265972. Article Request Form

Gallant J, Lazzarin A, Mills A, Orkin C, Podzamczer D, Tebas P, Girard PM, Brar I, Daar ES, Wohl D, Rockstroh J, Wei X, Custodio J, White K, Martin H, Cheng A, and Quirk E. Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US-380-1489): a double- blind, multicentre, phase 3, randomised controlled non-inferiority trial Lancet 2017;PMID: 28867497. Full Text

Jovanović M, Tošić T, Jovanović S, Stevanović G, Drakulović M, Stošović R, and Zervos M. Local spread of Tn1546- like element among three species of vancomycin resistant enterococci in an intensive care unit J Infect Dev Ctries 2017; 11(9):684-690. PMID: Not assigned. Article Request Form

Linder KA, Alkhouli L, Ramesh M, Alangaden GA, Kauffman CA, and Miceli MH. Effect of underlying immune compromise on the manifestations and outcomes of group A streptococcal bacteremia J Infect 2017;PMID: 28237623. Full text

Meighani A, Hart BR, Bourgi K, Miller N, John A, and Ramesh M. Outcomes of fecal microbiota transplantation for clostridium difficile infection in patients with inflammatory bowel disease Dig Dis Sci 2017;PMID: 28451916. Full Text

Mendo-Lopez R, Jasso L, Guevara X, Astocondor AL, Alejos S, Bardossy AC, Prentiss T, Zervos MJ, Jacobs J, and Garcia C. Multidrug-resistant microorganisms colonizing lower extremity wounds in patients in a tertiary care hospital, Lima, Peru Am J Trop Med Hyg 2017;PMID: 28722595. Request Article

Ordaya EE, Jarir SA, Yoo R, and Chandrasekar PH. Hemophagocytic lymphohistiocytosis (HLH): Elusive diagnosis of disseminated Mycobacterium avium complex infection Germs 2017; 7(3):149-152. PMID: 28932715. Full Text

Raccurt CP, Brasseur P, Ciceron M, Parke DM, Zervos MJ, and Boncy J. In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti Malar J 2017; 16(1):313. PMID: 28778206. Full Text

Sangave A, Komati R, Weinmann A, Samuel L, and Desai U. Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis Am J Ophthalmol Case Rep 2017; 7:149-152. PMID: 29260103. Full Text

Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell Iv J, Bixby D, Markowitz N, Morrison SJ, and Collins KL. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo PLoS Pathog 2017; 13(7):e1006509. PMID: 28732051. Full Text

69 Segaloff HE, Evans R, Arshad S, Zervos MJ, Archer C, Kaye KS, and Martin ET. The impact of obesity and timely antiviral administration on severe influenza outcomes among hospitalized adults J Med Virol 2017;PMID: 28892181. Full Text

Steinbrink J, Alexis M, Angulo-Thompson D, Ramesh M, Alangaden G, and Miceli MH. Mycobacterium marinum remains an unrecognized cause of indolent skin infections Cutis 2017; 100(5):331-336. PMID: 29232419. Full Text

Suleyman G, Mahan M, and Zervos MJ. Comparison of daptomycin and linezolid in the treatment of vancomycin-resistant enterococcus faecium in the absence of endocarditis Infect Dis Clin Pract 2017; 25(3):151- 154. PMID: Not assigned. Full Text

Veve MP, Davis SL, Williams AM, McKinnon JE, and Ghanem TA. Considerations for antibiotic prophylaxis in head and neck cancer surgery Oral Oncol 2017;PMID: 28943204. Full Text

Nephrology

Abu Jawdeh BG, Leonard AC, Sharma Y, Katipally S, Shields AR, Alloway RR, Woodle ES, and Thakar CV. Contrast-induced nephropathy in renal transplant recipients: A single center experience Front Med (Lausanne) 2017; 4:64. PMID: 28603715. Full Text

Bress AP, Kramer H, Khatib R, Beddhu S, Cheung AK, Hess R, Bansal VK, Cao G, Yee J, Moran AE, Durazo- Arvizu RA, Muntner P, and Cooper RS. Potential deaths averted and serious adverse events incurred from adoption of the sprint intensive blood pressure regimen in the u.S.: Projections from nhanes Circulation 2017;PMID: 28193605. Full text

Cheung AK, Rahman M, Reboussin DM, Craven TE, Greene T, Kimmel PL, Cushman WC, Hawfield AT, Johnson KC, Lewis CE, Oparil S, Rocco MV, Sink KM, Whelton PK, Wright JT, Jr., Basile J, Beddhu S, Bhatt U, Chang TI, Chertow GM, Chonchol M, Freedman BI, Haley W, Ix JH, Katz LA, Killeen AA, Papademetriou V, Ricardo AC, Servilla K, Wall B, Wolfgram D, and Yee J. Effects of intensive bp control in ckd J Am Soc Nephrol 2017;PMID: 28642330. Full Text

Cheungpasitporn W, Khoury NJ, Thongprayoon C, and Craici IM. Is remote ischemic conditioning of benefit to patients undergoing kidney transplantation? J Invest Surg 2017:1-3. PMID: 29023177. Article Request Form

Isakova T, Nickolas TL, Denburg M, Yarlagadda S, Weiner DE, Gutierrez OM, Bansal V, Rosas SE, Nigwekar S, Yee J, and Kramer H. KDOQI US commentary on the 2017 kdigo clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (ckd-mbd) Am J Kidney Dis 2017;PMID: 28941764. Full Text

Jasinski MJ, Lumley MA, Soman S, Yee J, and Ketterer MW. Indicators of cognitive impairment from a medical record review: Correlations with early (30-d) readmissions among hospitalized patients in a nephrology unit Psychosomatics 2017; 58(2):173-179. PMID: 28104336. Full Text

Liquete E, Williamson SR, Janakiraman N, and Venkat KK. Renal complications of hematopoietic stem cell transplantation: Report of a case and review of the literature Indian J Nephrol 2017; 27(6):468-471. PMID: 29217887. Full Text

Neu A, and Yee J. Learning from kids Adv Chronic Kidney Dis 2017; 24(6):343-345. PMID: 29229163. Full Text

Novak JE, Alamiri K, and Yee J. Dabigatran reversal in a patient with end-stage liver disease and acute kidney injury Am J Kidney Dis 2017;PMID: 28549534. Full Text

Novak JE, Alamiri K, and Yee J. In reply to 'idarucizumab dosing in kidney failure' Am J Kidney Dis 2017;PMID: 28985981. Full Text

Soi V, and Yee J. Sodium homeostasis in chronic kidney disease Adv Chronic Kidney Dis 2017; 24(5):325-331. PMID: 29031360. Full Text

Soman SS, and Yee J. Nephrology and telehealth: Now? Or now! Adv Chronic Kidney Dis 2017; 24(1):1-3. PMID: 28224936. Full text

70 Takahashi K, Prashar R, Putchakayala KG, Kane WJ, Denny JE, Kim DY, and Malinzak LE. Allograft loss from acute Page kidney secondary to trauma after kidney transplantation World J Transplant 2017; 7(1):88-93. PMID: 28280700. Full Text

Takahashi K, Patel AK, Nagai S, Safwan M, Putchakayala KG, Kane WJ, Malinzak LE, Denny JE, Yoshida A, and Kim DY. Perioperative ketorolac use: A potential risk factor for renal dysfunction after live-donor nephrectomy Ann Transplant 2017; 22:563-569. PMID: 28924138. Full Text

Umanath K, Greco B, Jalal DI, McFadden M, Sika M, Koury MJ, Niecestro R, Hunsicker LG, Greene T, Lewis JB, and Dwyer JP. The safety of achieved iron stores and their effect on IV iron and ESA use: post-hoc results from a randomized trial of ferric citrate as a phosphate binder in dialysis Clin Nephrol 2017; 87 (2017)(3):124-133. PMID: 28128726. Full Text

Umanath K, and Emani S. Getting to the heart of the matter: Review of treatment of cardiorenal syndrome Adv Chronic Kidney Dis 2017; 24(4):261-266. PMID: 28778367. Full Text

Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, and Bazil JN. The effect of respiration buffer composition on mitochondrial metabolism and function PLoS One 2017; 12(11):e0187523. PMID: 29091971. Full Text

Yee J. The tubulointerstitium: Dark matter Adv Chronic Kidney Dis 2017; 24(2):51-54. PMID: 28284378. Full Text

Yee J. Prophylactic hemodialysis for protection against gadolinium-induced nephrogenic systemic fibrosis: A doll's house Adv Chronic Kidney Dis 2017; 24(3):133-135. PMID: 28501073. Full Text

Yee J, and Campbell RC. The interdisciplinary chronic kidney disease clinic: End of the beginning, not beginning of the end Am J Nephrol 2017; 45(6):461-463. PMID: 28501858. Full Text

Yee J, and Campbell RC. The AKI clinic for fragile patients Adv Chronic Kidney Dis 2017; 24(4):189-191. PMID: 28778356. Full Text

Yee J. Hyperkalemia: Inpatient PaniK Adv Chronic Kidney Dis 2017; 24(5):267-271. PMID: 29031351. Full Text

Pulmonary and Critical Care Medicine

Awdish RL. A view from the edge - creating a culture of caring N Engl J Med 2017; 376(1):7-9. PMID: 28052225. Full Text

Awdish RL, Mendez MP, MacDonald N, Yessayan L, Jennings JH, Albujoq K, Hegab S, and Cajigas HR. Low rate of adverse events associated with inpatient parenteral prostacyclins J Healthc Qual 2017; 39(5):e84-e90. PMID: 27631708. Article Request Form

Berry LL, Danaher TS, Beckham D, Awdish RLA, and Mate KS. When patients and their families feel like hostages to health care Mayo Clin Proc 2017; 92(9):1373-1381. PMID: 28843434. Full Text

Berry LL, Danaher TS, Chapman RA, and Awdish RLA. Role of kindness in cancer care J Oncol Pract 2017:Jop2017026195. PMID: 29035616. Full Text

Chaaban S, Simoff M, Ray C, and Diaz-Mendoza J. Posterior Tracheal Laceration Treated with a Stent Ann Am Thorac Soc 2017; 14(7):1224-1226. PMID: 28665706. Full Text

Chen Y, Khemasuwan D, and Simoff MJ. Lung cancer screening: Detected nodules, what next? Lung Cancer Manag 2017; 5(4):173-184. PMID: Not assigned. Article Request Form

Gould MK, Sakoda LC, Ritzwoller DP, Simoff MJ, Neslund-Dudas CM, Kushi LH, Carter-Harris L, Feigelson HS, Minowada G, and Doria-Rose VP. Monitoring lung cancer screening utilization and outcomes in four cancer research network sites Ann Am Thorac Soc 2017;PMID: 28683215. Full Text

Gunasekaran K, Ahmad MR, Murthi S, and Jennings J. Granulomatosis with polyangiitis (GPA) presenting as thick walled cavitary lung lesion Qjm 2017;PMID: 28541566. Full Text

Kioka MJ, DiGiovine B, Rezik M, and Jennings JH. Anaerobic antibiotic usage for pneumonia in the medical intensive care unit Respirology 2017;PMID: 28677255. Full Text

71 Mullon JJ, Burkart KM, Silvestri G, Hogarth DK, Almeida F, Berkowitz D, Eapen G, Feller-Kopman D, Fessler HE, Folch E, Gillespie C, Haas A, Islam S, Lamb C, Levine SM, Majid A, Maldonado F, Musani A, Piquette C, Ray C, Reddy C, Rickman O, Simoff M, Wahidi MM, and Lee H. Interventional pulmonology fellowship accreditation standards: Executive summary of the multi-society interventional pulmonology fellowship accreditation committee Chest 2017;PMID: 28132754. Full Text

Ouellette DR, and Lavoie KL. Recognition, diagnosis, and treatment of cognitive and psychiatric disorders in patients with COPD Int J Chron Obstruct Pulmon Dis 2017; 12:639-650. PMID: 28243081. Full text Ouellette DR, Patel S, Girard TD, Schmidt GA, Truwit JD, and Kress JP. Response Chest 2017; 151(6):1400-1401. PMID: 28599936. Full Text

Rahaghi FF, Alnuaimat H, Awdish RLA, Balasubramanian VP, Bourge RC, Burger CD, Butler JA, Cauthen CG, Chakinala M, deBoisblanc BP, Eggert MS, Engel P, Feldman J, McConnell JW, Park MH, Sager JS, Sood N, and Palevsky HI. Express: Recommendations for the clinical management of patients receiving macitentan for pulmonary arterial hypertension (pah): A delphi consensus document Pulm Circ 2017:2045893217721695. PMID: 28671484. Request Article

Schmidt GA, Girard TD, Kress JP, Morris PE, Ouellette DR, Alhazzani W, Burns SM, Epstein SK, Esteban A, Fan E, Ferrer M, Fraser GL, Gong MN, Hough CL, Mehta S, Nanchal R, Patel S, Pawlik AJ, Schweickert WD, Sessler CN, Strom T, Wilson KC, and Truwit JD. Liberation from mechanical ventilation in critically ill adults: Executive summary of an official american college of chest physicians/american thoracic society clinical practice guideline Chest 2017; 151(1):160-165. PMID: 27818329. Full Text

Smith AL, Palmer V, Farhat N, Kalus JS, Thavarajah K, Digiovine B, and Macdonald NC. Hospital-based clinical pharmacy services to improve ambulatory management of chronic obstructive pulmonary disease J Pharm Technol 2017; 33(1):8-14. PMID: Not assigned. Full Text

Shellenberger RA, Balakrishnan B, Avula S, Ebel A, and Shaik S. Diagnostic value of the physical examination in patients with dyspnea Cleve Clin J Med 2017; 84(12):943-950. PMID: 29244648. Full Text

Tatem G, Kokas M, Smith CL, and DiGiovine B. A feasibility assessment of behavioral-based interviewing to improve candidate selection for a pulmonary and critical care medicine fellowship program Ann Am Thorac Soc 2017;PMID: 28306323. Full Text

Tatem G, Kokas M, Smith CL, and DiGiovine B. Reply: Combining efforts for positive progress in the graduate medical education match process Ann Am Thorac Soc 2017; 14(8):1358-1359. PMID: 28723245. Full Text

Truwit JD, Girard TD, Kress JP, Ouellette DR, and Schmidt GA. Response Chest 2017; 151(5):1180-1181. PMID: 28483111. Full Text

Rheumatology

Broder A, Mowrey WB, Khan HN, Jovanovic B, Londono-Jimenez A, Izmirly P, and Putterman C. Tubulointerstitial damage predicts end stage renal disease in lupus nephritis with preserved to moderately impaired renal function: A retrospective cohort study Semin Arthritis Rheum 2017;PMID: 28803673. Full Text

Dozmorov MG, Coit P, Maksimowicz-McKinnon K, and Sawalha AH. Age-associated DNA methylation changes in naive CD4+ T cells suggest an evolving autoimmune epigenotype in aging T cells Epigenomics 2017;PMID: 28322571. Article Request Form

Maranda EL, Sheinin R, Brys A, Rubin B, and Lim HW. A case of eosinophilic fasciitis associated with pyoderma gangrenosum J Eur Acad Dermatol Venereol 2017;PMID: 28150344. Full Text

Namas R, Beydoun N, and Meysami A. Breast calcinosis in a patient with dermatomyositis Eur J Rheumatol 2017; 4(2):175-176. PMID: 28638697. Full Text

Sleep Medicine

Cheng P, Tallent G, Bender TJ, Tran KM, and Drake CL. Shift work and cognitive flexibility: Decomposing task performance J Biol Rhythms 2017; 32(2):143-153. PMID: 28470121. Full Text

72 Dauvilliers Y, Roth T, Guinta D, Alvarez-Horine S, Dynin E, and Black J. Effect of sodium oxybate, modafinil, and their combination on disrupted nighttime sleep in narcolepsy Sleep Med 2017; 40:53-57. PMID: 29221779. Full Text

Dolsen MR, Cheng P, Arnedt JT, Swanson L, Casement MD, Kim HS, Goldschmied JR, Hoffmann RF, Armitage R, and Deldin PJ. Neurophysiological correlates of suicidal ideation in major depressive disorder: Hyperarousal during sleep J Affect Disord 2017; 212:160-166. PMID: 28192765. Full text

Drake CL, Cheng P, Almeida DM, and Roth T. Familial risk for insomnia is associated with abnormal cortisol response to stress Sleep 2017; 40(10)PMID: 28958055. Full Text

Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, and Michelson D. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data Psychopharmacology (Berl) 2017;PMID: 28265715. Full Text

Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, and Michelson D. Suvorexant in elderly patients with insomnia: Pooled analyses of data from phase III randomized controlled clinical trials Am J Geriatr Psychiatry 2017;PMID: 28427826. Full Text

Pillai V, Roth T, Roehrs T, Moss K, Peterson EL, and Drake CL. Effectiveness of benzodiazepine receptor agonists in the treatment of insomnia: An examination of response and remission rates Sleep 2017; 40(2)PMID: 28364510. Full Text

Roehrs TA, and Roth T. Increasing presurgery sleep reduces postsurgery pain and analgesic use following joint replacement: a feasibility study Sleep Med 2017; 33:109-113. PMID: 28449888. Full Text

Roth T, Black J, Cluydts R, Charef P, Cavallaro M, Kramer F, Zammit G, and Walsh J. Dual orexin receptor antagonist, almorexant, in elderly patients with primary insomnia: A randomized, controlled study Sleep 2017; 40(2):8. PMID: 28364509. Full Text van Schrojenstein Lantman M, Mackus M, Roth T, and Verster JC. Total sleep time, alcohol consumption, and the duration and severity of alcohol hangover Nat Sci Sleep 2017; 9:181-186. PMID: 28721110. Full Text

Vargas I, Drake CL, and Lopez-Duran NL. Insomnia symptom severity modulates the impact of sleep deprivation on attentional biases to emotional information Cognit Ther Res 2017:1-11. PMID: Not assigned. Full Text

General Internal Medicine/Palliative Medicine/Hospitalist/Other

Barnes GD, Kaatz S, Lopez A, Gu X, Kozlowski J, Krol GD, and Froehlich JB. Discontinuation of warfarin therapy for patients with atrial fibrillation: The michigan anticoagulation quality improvement initiative experience JAMA Cardiol 2017;PMID: 28052153. Full Text

Barnes GD, Misirliyan S, Kaatz S, Jackson EA, Haymart B, Kline-Rogers E, Kozlowski J, Krol G, Froehlich JB, and Sales A. Barriers and facilitators to reducing frequent laboratory testing for patients who are stable on warfarin: a mixed methods study of de-implementation in five anticoagulation clinics Implement Sci 2017; 12(1):87. PMID: 28709455. Full Text

Chopra V, Kaatz S, Conlon A, Paje D, Grant PJ, Rogers MAM, Bernstein SJ, Saint S, and Flanders SA. The michigan risk score to predict peripherally inserted central catheter-associated thrombosis J Thromb Haemost 2017;PMID: 28796444. Full Text

Douketis JD, Spyropoulos AC, Anderson JM, Arnold DM, Bates SM, Blostein M, Carrier M, Caprini JA, Clark NP, Coppens M, Dentali F, Duncan J, Gross PL, Kassis J, Kowalski S, Lee AY, Le Gal G, Le Templier G, Li N, MacKay E, Shah V, Shivakumar S, Solymoss S, Spencer FA, Syed S, Tafur AJ, Vanassche T, Thiele T, Wu C, Yeo E, and Schulman S. The perioperative anticoagulant use for surgery evaluation (PAUSE) study for patients on a direct oral anticoagulant who need an elective surgery or procedure: Design and rationale Thromb Haemost 2017; 117(12):2415-2424. PMID: 29212129. Full Text

Gunasekaran K, Rudd KM, Murthi S, Kaatz S, and Lone N. Spontaneous thyroid hemorrhage on chronic anticoagulation therapy Clin Pract 2017; 7(1):932. PMID: 28243434. Full text

73 Gunasekaran K, Winans ARM, Murthi S, Ahmad MR, and Kaatz S. Rectus sheath hematoma associated with apixaban Clin Pract 2017; 7(3):957. PMID: 28808519. Full Text

Kaatz S, Mahan CE, Nakhle A, Gunasekaran K, Ali M, Lavender R, and Paje DG. Management of elective surgery and emergent bleeding with direct oral anticoagulants Curr Cardiol Rep 2017; 19(12):124. PMID: 29064044. Full Text

Kaatz S, Coleman CI, Bookhart B, Laliberte F, Nelson WW, Brown K, Martin S, Schein J, and Lefebvre P. Implications of stroke and bleeding risk-scores and comorbidities on episode-based bundled payments for patients with nonvalvular atrial fibrillation Curr Med Res Opin 2017:1-28. PMID: 29164990. Article Request Form

Kataruka A, Kong X, Haymart B, Kline-Rogers E, Almany S, Kozlowski J, Krol GD, Kaatz S, McNamara MW, Froehlich JB, and Barnes GD. SAMe-TT2R2 predicts quality of anticoagulation in patients with acute venous thromboembolism: The MAQI2 experience Vasc Med 2017:1358863x16682863. PMID: 28145152. Full Text

Khorana AA, Berger JS, Wells PS, Seheult R, Ashton V, Laliberte F, Crivera C, Lejeune D, Schein J, Wildgoose P, Lefebvre P, and Kaatz S. Risk for venous thromboembolism recurrence among rivaroxaban-treated patients who continued versus discontinued therapy: Analyses among patients with vte Clin Ther 2017;PMID: 28645879. Full Text

Smith SN, Moureau N, Vaughn VM, Boldenow T, Kaatz S, Grant PJ, Bernstein SJ, Flanders SA, and Chopra V. Patterns and predictors of peripherally inserted central catheter occlusion: The 3p-o study J Vasc Interv Radiol 2017;PMID: 28292637. Full Text

Spencer M, Lenhart A, Baker J, Dickens J, Weissman A, Read AJ, Saini S, and Saini SD. Primary care physicians are under-testing for celiac disease in patients with iron deficiency anemia: Results of a national survey PLoS One 2017; 12(9):e0184754. PMID: 28931034. Full Text

Weiss R, Vittinghoff E, Fang MC, Cimino JEW, Chasteen KA, Arnold RM, Auerbach AD, and Anderson WG. Associations of physician empathy with patient anxiety and ratings of communication in hospital admission encounters J Hosp Med 2017; 12(10):805-810. PMID: 28991945. Article Request Form

NEUROLOGY

Ali R, Elsayed M, Kaur M, Air E, Mahmood N, Constantinou J, and Schwalb J. Use of social media to assess the effectiveness of vagal nerve stimulation in Dravet syndrome: A caregiver's perspective J Neurol Sci 2017; 375:146-149. PMID: 28320117. Full Text

Al-Mufti F, and Mayer SA. Neurocritical care of acute subdural hemorrhage Neurosurg Clin N Am 2017; 28(2):267- 278. PMID: 28325461. Full Text

Bagic AI, Bowyer SM, Kirsch HE, Funke ME, and Burgess RC. American Clinical MEG Society (ACMEGS) Position Statement #2: The value of magnetoencephalography (meg)/magnetic source imaging (msi) in noninvasive presurgical mapping of eloquent cortices of patients preparing for surgical interventions J Clin Neurophysiol 2017;PMID: 28059855. Full Text

Boutros NN, Kang SS, Gustafson KM, Thomas Z, Sagduyu K, Pearson J, and Bowyer SM. A magnetoencephalography investigation of coherence source imaging in panic disorder Neuroreport 2017; 28(13):833- 837. PMID: 28658047. Full Text

Cerquera A, Gjini K, Bowyer SM, and Boutros N. Comparing eeg nonlinearity in deficit and nondeficit schizophrenia patients: Preliminary data Clin EEG Neurosci 2017:1550059417715388. PMID: 28618836. Full Text

Chartrain AG, Awad AJ, Sarkiss CA, Feng R, Liu Y, Mocco J, Bederson JB, Mayer SA, Dangayach NS, and Gordon E. A step-down unit transfer protocol for low-risk aneurysmal subarachnoid hemorrhage Neurosurg Focus 2017; 43(5):E15. PMID: 29088946. Full Text

Chen J, Cui C, Yang X, Xu J, Venkat P, Zacharek A, Yu P, and Chopp M. Mir-126 affects brain-heart interaction after cerebral ischemic stroke Transl Stroke Res 2017;PMID: 28101763. Article Request Form

Chen Z, Venkat P, Seyfried D, Chopp M, Yan T, and Chen J. Brain-heart interaction: Cardiac complications after stroke Circ Res 2017; 121(4):451-468. PMID: 28775014. Full Text

74 Dangayach NS, Caridi J, Bederson J, and Mayer SA. Enhanced recovery after neurosurgery: Paradigm shift and call to arms World Neurosurg 2017; 100:683-685. PMID: 28254597. Full Text

Dar S, Chhina J, Mert I, Chitale D, Buekers T, Kaur H, Giri S, Munkarah A, and Rattan R. Bioenergetic adaptations in chemoresistant ovarian cancer cells Sci Rep 2017; 7(1):8760. PMID: 28821788. Request Article

Ding G, Chen J, Chopp M, Li L, Yan T, Davoodi-Bojd E, Li Q, Davarani SP, and Jiang Q. White matter changes after stroke in type 2 diabetic rats measured by diffusion magnetic resonance imaging J Cereb Blood Flow Metab 2017; 37(1):241-251. PMID: 26685128. Full Text

Garvey GP, Wasade VS, Murphy KE, and Balki M. Anesthetic and Obstetric Management of Syringomyelia During Labor and Delivery: A Case Series and Systematic Review Anesth Analg 2017;PMID: 28598915. Full Text

Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Jr., Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, and Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy Epilepsia 2017;PMID: 28398014. Full Text

Gonawala S, and Ali MM. Application of dendrimer-based nanoparticles in glioma imaging J Nanomed Nanotechnol 2017; 8(3)PMID: 28856067. Full Text

Hevesi M, Bershad EM, Jafari M, Mayer SA, Selim M, Suarez JI, and Divani AA. Untreated hypertension as predictor of in-hospital mortality in intracerebral hemorrhage: A multi-center study J Crit Care 2017; 43:235-239. PMID: 28934706. Full Text

Howell BN, and Newman DS. Dysfunction of central control of breathing in amyotrophic lateral sclerosis Muscle Nerve 2017;PMID: 28063152. Full Text

Jia J, Wei C, Jia L, Tang Y, Liang J, Zhou A, Li F, Shi L, and Doody RS. Efficacy and safety of donepezil in chinese patients with severe alzheimer's disease: A randomized controlled trial J Alzheimers Dis 2017;PMID: 28157100. Article Request Form

Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King-Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Jr., Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, and Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas Epilepsia 2017;PMID: 28387951. Full Text

Kassis H, Shehadah A, Chopp M, and Zhang ZG. Epigenetics in stroke recovery Genes (Basel) 2017; 8(3)PMID: 28264471. Full Text

Kelley BP, Patel SC, Marin HL, Corrigan JJ, Mitsias PD, and Griffith B. Autoimmune encephalitis: Pathophysiology and imaging review of an overlooked diagnosis AJNR Am J Neuroradiol 2017;PMID: 28183838. Full text

Kolpakova J, Li L, Hatcher JT, Gu H, Zhang X, Chen J, and Cheng ZJ. Responses of Nucleus Tractus Solitarius (NTS) early and late neurons to blood pressure changes in anesthetized F344 rats PLoS One 2017; 12(4):e0169529. PMID: 28384162. Full Text

Konnai R, Scherer RC, Peplinski A, and Ryan K. Whisper and phonation: Aerodynamic comparisons across adduction and loudness J Voice 2017;PMID: 28366247. Full Text

Lahiri S, Schlick KH, Padrick MM, Rinsky B, Gonzalez N, Jones H, Mayer SA, and Lyden PD. Cerebral pulsatility index is elevated in patients with elevated right atrial pressure J Neuroimaging 2017;PMID: 28670797. Full Text

LeWitt PA, Li J, Lu M, Guo L, and Auinger P. Metabolomic biomarkers as strong correlates of Parkinson disease progression Neurology 2017;PMID: 28179471. Full text

75 LeWitt P. Portrayal of progressive supranuclear palsy in the 16th century Lancet Neurol 2017; 16(12):956-957. PMID: 29165255. Full Text

Li L, Chopp M, Ding G, Li Q, Mahmood A, and Jiang Q. Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study Brain Res 2017; 1675:61-70. PMID: 28899758. Full Text

Lin Y, Luo LL, Sun J, Gao W, Tian Y, Park E, Baker A, Chen J, Jiang R, and Zhang J. Relationship of circulating cxcr4+ epc with prognosis of mild traumatic brain injury patients Aging Dis 2017; 8(1):115-127. PMID: 28203485. Full text

Liu Q, Zhang X, Yin C, Chen X, Zhang Z, Brown S, Xie H, Zhou L, and Mi QS. HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function Oncotarget 2017;PMID: 28177888. Full text

Liu XS, Fan B, Szalad A, Jia L, Wang L, Wang X, Pan W, Zhang L, Zhang R, Hu J, Zhang XM, Chopp M, and Zhang ZG. Microrna-146a mimics reduce the peripheral neuropathy in type ii diabetic mice Diabetes 2017;PMID: 28899883. Full Text

Loeffler DA, Klaver AC, Coffey MP, Aasly JO, and LeWitt PA. Increased oxidative stress markers in cerebrospinal fluid from healthy subjects with parkinson's disease-associated lrrk2 gene mutations Front Aging Neurosci 2017; 9:89. PMID: 28420983. Full Text

Lyden P, Mayer SA, Lurie K, and Schmutzhard E. Temperature management in neurological and neurosurgical intensive care unit Ther Hypothermia Temp Manag 2017; 7(2):70-74. PMID: 28586295. Article Request Form

Mahajan A, Deal JA, and Carlson M. Interventions in Parkinson's disease: Role of executive function Front Biosci (Landmark Ed) 2017; 22:416-427. PMID: 27814622. Article Request Form

Mahajan A, and Sidiropoulos C. TPK1 mutation induced childhood onset idiopathic generalized dystonia: Report of a rare mutation and effect of deep brain stimulation J Neurol Sci 2017; 376:42-43. PMID: 28431625. Full Text

Mahajan A, Alshammaa A, Zillgitt A, Bowyer SM, LeWitt P, Kaminski P, and Sidiropoulos C. The effect of botulinum toxin on network connectivity in cervical dystonia: Lessons from magnetoencephalography Tremor Other Hyperkinet Mov (N Y) 2017; 7:502. PMID: 29204314. Full Text

Mayer SA. Announcing CURRENT CONCEPTS: Exploring what is new, provocative, and controversial in neurocritical care Neurocrit Care 2017; 26(3):464. PMID: 28523595. Full Text

Mayer SA, Fischer M, Polderman KH, and Atkins C. Intraoperative Temperature Management Ther Hypothermia Temp Manag 2017; 7(2):66-69. PMID: 28561599. Article Request Form

Memon AB, and Playfoot KA. Radiation-induced tongue myokymia with hypoglossal nerve damage, mimicker of motor neuron disease Clin Case Rep 2017; 5(6):1056-1057. PMID: 28588874. Full Text

Mert I, Chhina J, Allo G, Dai J, Seward S, Carey MS, Llaurado M, Giri S, Rattan R, and Munkarah AR. Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer Gynecol Oncol 2017;PMID: 28545687. Full Text

Mirza S, Yazdani U, Dewey Iii R, Patel N, Dewey RB, Jr., Miocinovic S, and Chitnis S. Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and Review Parkinsons Dis 2017; 2017:3410820. PMID: 28706748. Full Text

Modi S, Mahajan A, Dharaiya D, Varelas P, and Mitsias P. Burden of herpes simplex virus encephalitis in the United States J Neurol 2017; 264(6):1204-1208. PMID: 28516331. Full Text

Morris DC, Cheung WL, Loi R, Zhang T, Lu M, Zhang ZG, and Chopp M. Thymosin beta4 for the treatment of acute stroke in aged rats Neurosci Lett 2017; 659:7-13. PMID: 28864242. Full Text

Nagaraja TN, Elmghirbi R, Brown SL, Schultz LR, Lee IY, Keenan KA, Panda S, Cabral G, Mikkelsen T, and Ewing JR. Reproducibility and relative stability in magnetic resonance imaging indices of tumor vascular physiology over a period of 24h in a rat 9L gliosarcoma model Magn Reson Imaging 2017; 44:131-139. PMID: 28887206. Full Text

76 Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. A parametric model of the brain vascular system for estimation of the arterial input function (AIF) at the tissue level NMR Biomed 2017;PMID: 28211963. Full text

Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. An extended vascular model for less biased estimation of permeability parameters in DCE-T1 images NMR Biomed 2017;PMID: 28211961. Full text

Niethammer M, Tang CC, LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Sapan CV, Eidelberg D, During MJ, Kaplitt MG, and Feigin A. Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease JCI Insight 2017; 2(7):e90133. PMID: 28405611. Full Text

Ning R, Venkat P, Chopp M, Zacharek A, Yan T, Cui X, Seyfried D, and Chen J. D-4F increases microRNA- 124a and reduces neuroinflammation in diabetic stroke rats Oncotarget 2017; 8(56):95481-95494. PMID: 29221142. Full Text

Price RG, Knight RA, Hwang KP, Bayram E, Nejad-Davarani SP, and Glide-Hurst CK. Optimization of a novel large field of view distortion phantom for MR-only treatment planning J Appl Clin Med Phys 2017;PMID: 28497476. Full Text

Ramadan AR, and Varelas PN. Management of status epilepticus in adults J Clin Outcomes Manag 2017; 24(8):371- 384. PMID: Not assigned. Request Article

Rammo R, Robin A, John J, Pabaney A, Varelas P, and Kole M. Management of acute subdural hematoma in a patient with portopulmonary hypertension on prostanoid therapy Surg Neurol Int 2017; 8:161. PMID: 28840065. Full Text

Rao JU, Coman D, Walsh JJ, Ali MM, Huang Y, and Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH Sci Rep 2017; 7(1):7865. PMID: 28801587. Full Text

Riederer P, Korczyn AD, Ali SS, Bajenaru O, Choi MS, Chopp M, Dermanovic-Dobrota V, Grunblatt E, Jellinger KA, Kamal MA, Kamal W, Leszek J, Sheldrick-Michel TM, Mushtaq G, Meglic B, Natovich R, Pirtosek Z, Rakusa M, Salkovic-Petrisic M, Schmidt R, Schmitt A, Sridhar GR, Vecsei L, Wojszel ZB, Yaman H, Zhang ZG, and Cukierman- Yaffe T. The diabetic brain and cognition J Neural Transm (Vienna) 2017;PMID: 28766040. Full Text

Romero CA, Cabral G, Knight RA, Ding G, Peterson EL, and Carretero OA. Non-invasive measurement of renal blood flow by magnetic resonance imaging (mri) in rats Am J Physiol Renal Physiol 2017:ajprenal.00332.02017. PMID: 28978533. Full Text

Sidiropoulos C, Bowyer SM, Zillgitt A, LeWitt PA, Bagher-Ebadian H, Davoodi-Bojd E, Schwalb JM, Rammo R, Air E, and Soltanian-Zadeh H. Multimodal imaging in a patient with hemidystonia responsive to gpi deep brain stimulation Case Rep Neurol Med 2017; 2017:9653520. PMID: 28744382. Full Text

Sivakumar S, Taccone FS, Rehman M, Hinson H, Naval N, and Lazaridis C. Hemodynamic and neuro-monitoring for neurocritically ill patients: An international survey of intensivists J Crit Care 2017; 39:40-47. PMID: 28171804. Full text

Torbey MT, Brophy GM, Varelas PN, Bosel J, Manno E, Bader MK, Suarez JI, Seder D, and Freeman WD. Guidelines for family-centered care in neuro-icu populations: Caveats for routine palliative care Crit Care Med 2017; 45(6):e620-e621. PMID: 28509746. Full Text

Trosch RM, Espay AJ, Truong D, Gil R, Singer C, LeWitt PA, Lew MF, Tagliati M, Adler CH, Chen JJ, Marchese D, and Comella CL. Multicenter observational study of abobotulinumtoxinA neurotoxin in cervical dystonia: The ANCHOR-CD registry J Neurol Sci 2017; 376:84-90. PMID: 28431634. Full Text

Tsivgoulis G, Katsanos AH, Zand R, Sharma VK, Kohrmann M, Giannopoulos S, Dardiotis E, Alexandrov AW, Mitsias PD, Schellinger PD, and Alexandrov AV. Antiplatelet pretreatment and outcomes in intravenous thrombolysis for stroke: a systematic review and meta-analysis J Neurol 2017; 264(6):1227- 1235. PMID: 28550481. Full Text

77 Tsivgoulis G, Lioutas VA, Varelas P, Katsanos AH, Goyal N, Mikulik R, Barlinn K, Krogias C, Sharma VK, Vadikolias K, Dardiotis E, Karapanayiotides T, Pappa A, Zompola C, Triantafyllou S, Kargiotis O, Ioakeimidis M, Giannopoulos S, Kerro A, Tsantes A, Mehta C, Jones M, Schroeder C, Norton C, Bonakis A, Chang J, Alexandrov AW, Mitsias P, and Alexandrov AV. Direct oral anticoagulant- vs vitamin K antagonist-related nontraumatic intracerebral hemorrhage Neurology 2017;PMID: 28814457. Full Text

Varelas PN, Brady P, Rehman M, Afshinnik A, Mehta C, Abdelhak T, and Wijdicks EF. Primary posterior fossa lesions and preserved supratentorial cerebral blood flow: Implications for brain death determination Neurocrit Care 2017;PMID: 28828556. Full Text

Venkat P, Chopp M, and Chen J. Blood-brain barrier disruption, vascular impairment, and ischemia/reperfusion damage in diabetic stroke J Am Heart Assoc 2017; 6(6)PMID: 28572280. Full Text

Wang HH, Varelas PN, Henderson GV, Wijdicks EF, and Greer DM. Improving uniformity in brain death determination policies over time Neurology 2017; 88(6):562-568. PMID: 28077490. Full Text

Wang L, Chopp M, and Zhang ZG. PDE5 inhibitors promote recovery of peripheral neuropathy in diabetic mice Neural Regen Res 2017; 12(2):218-219. PMID: 28400802. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361504/

Wartenberg KE, and Mayer SA. Determining the optimal target blood pressure after thrombectomy: High or low? Neurology 2017; 89(6):528-529. PMID: 28687719. Full Text

Wei X, Shi B, Koo I, Yin X, Lorkiewicz P, Suhail H, Rattan R, Giri S, McClain CJ, and Zhang X. Analysis of stable isotope assisted metabolomics data acquired by GC-MS Anal Chim Acta 2017; 980:25-32. PMID: 28622800. Article Request Form

Xin H, Wang F, Li Y, Lu QE, Cheung WL, Zhang Y, Zhang ZG, and Chopp M. Secondary release of exosomes from astrocytes contributes to the increase in neural plasticity and improvement of functional recovery after stroke in rats treated with exosomes harvested from microrna 133b-overexpressing multipotent mesenchymal stromal cells Cell Transplant 2017; 26(2):243-257. PMID: 27677799. Full text

Xin H, Katakowski M, Wang F, Qian JY, Liu XS, Ali MM, Buller B, Zhang ZG, and Chopp M. Microrna cluster mir- 17-92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats Stroke 2017;PMID: 28232590. Full text

Xiong Y, Mahmood A, and Chopp M. Emerging potential of exosomes for treatment of traumatic brain injury Neural Regen Res 2017; 12(1):19-22. PMID: 28250732. Full text

Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, and Schwamm LH. Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke: A scientific statement for healthcare professionals from the american heart association/american stroke association Stroke 2017; 48(12):e343-e361. PMID: 29097489. Full Text

Yang S, Mei S, Jin H, Zhu B, Tian Y, Huo J, Cui X, Guo A, and Zhao Z. Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier PLoS One 2017; 12(10):e0187017. PMID: 29059256. Full Text

Yu SJ, Airavaara M, Wu KJ, Harvey BK, Liu HS, Yang Y, Zacharek A, Chen J, and Wang Y. 9-cis retinoic acid induces neurorepair in stroke brain Sci Rep 2017; 7(1):4512. PMID: 28674431. Full Text

Yu X, Yang L, Song R, Jiaerken Y, Yang J, Lou M, Jiang Q, and Zhang M. Changes in structure and perfusion of grey matter tissues during recovery from Ischaemic subcortical stroke: a longitudinal MRI study Eur J Neurosci 2017; 46(7):2308-2314. PMID: 28833690. Full Text

Zhang F, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, and Hao J. Vinpocetine inhibits nf- kappab-dependent inflammation in acute ischemic stroke patients Transl Stroke Res 2017;PMID: 28691141. Request Article

Zhang J, Gang Zhang Z, Lu M, Wang X, Shang X, Elias SB, and Chopp M. Mir-146a promotes remyelination in a cuprizone model of demyelinating injury Neuroscience 2017;PMID: 28237816. Full text

Zhang L, Chopp M, Lu M, Zhang T, Li C, Winter S, Brandstaetter H, Doppler E, Meier D, Pabla P, and Zhang ZG. Demonstration of therapeutic window of Cerebrolysin in embolic stroke: A prospective, randomized, blinded, and placebo-controlled study Int J Stroke 2017:1747493017702665. PMID: 28382851. Article Request Form

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Zhang Y, Zhang ZG, Chopp M, Meng Y, Zhang L, Mahmood A, and Xiong Y. Treatment of traumatic brain injury in rats with N-acetyl-seryl-aspartyl-lysyl-proline J Neurosurg 2017; 126(3):782-795. PMID: 28245754. Full text

Zhou ZW, Li YD, Gao WW, Chen JL, Yue SY, and Zhang JN. Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury Neural Regen Res 2017; 12(8):1322-1328. PMID: 28966648. Full Text

Zhou ZW, Li F, Zheng ZT, Li YD, Chen TH, Gao WW, Chen JL, and Zhang JN. Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury Brain Behav 2017; 7(11):e00827. PMID: 29201540. Full Text

NEUROSURGERY

Ali R, Elsayed M, Kaur M, Air E, Mahmood N, Constantinou J, and Schwalb J. Use of social media to assess the effectiveness of vagal nerve stimulation in Dravet syndrome: A caregiver's perspective J Neurol Sci 2017; 375:146-149. PMID: 28320117. Full Text

Basal LA, Bailey MD, Romero J, Ali MM, Kurenbekova L, Yustein J, Pautler RG, and Allen MJ. Fluorinated Eu- II- based multimodal contrast agent for temperature- and redox-responsive magnetic resonance imaging Chemical Science 2017; 8(12):8345-8350. PMID: Not assigned. Full Text

Basheer A, Rammo R, Kalkanis S, Felicella MM, and Chedid M. Multifocal intradural extramedullary pilocytic astrocytomas of the spinal cord: A case report and review of the literature Neurosurgery 2017; 80(2):E178-e184. PMID: 28173580. Full text

Basheer A, Alsaidi M, Schultz L, Chedid M, Abdulhak M, and Seyfried D. Preventive effect of tamsulosin on postoperative urinary retention in neurosurgical patients Surg Neurol Int 2017; 8:75. PMID: 28584678. Full Text

Basheer A, Macki M, Buraimoh M, and Mahmood A. Chronic thoracolumbar subdural empyema: Case report and surgical management Surg Neurol Int 2017; 8:167. PMID: 28840071. Full Text

Basheer A, Macki M, and Mahmood A. Traumatic pneumocephaly: trapped air from where? BMJ Case Rep 2017; 2017PMID: 29175906. Full Text

Bilsky MH, Chang SD, Gerszten PC, and Kalkanis S. Introduction: Spinal radiosurgery Neurosurg Focus 2017; 42(1):E2. PMID: 28041322. Full Text

Boyce-Fappiano D, Elibe E, Schultz L, Ryu S, Siddiqui MS, Chetty I, Lee I, Rock J, Movsas B, and Siddiqui F. Analysis of the factors contributing to vertebral compression fractures after spine stereotactic radiosurgery Int J Radiat Oncol Biol Phys 2017; 97(2):236-245. PMID: 28068232. Full Text

Boyce-Fappiano D, Elibe E, Zhao B, Siddiqui MS, Lee I, Rock J, Ryu S, and Siddiqui F. Reirradiation of the spine with stereotactic radiosurgery: Efficacy and toxicity Pract Radiat Oncol 2017;PMID: 28673511. Request Article

Brusatori M, Auner G, Noh T, Scarpace L, Broadbent B, and Kalkanis SN. Intraoperative raman spectroscopy Neurosurg Clin N Am 2017; 28(4):633-652. PMID: 28917291. Full Text

Buraimoh MA, Massie LW, and Montgomery DM. Lateral atlantoaxial osteoarthritis: A narrative literature review Clin Spine Surg 2017; 30(10):433-438. PMID: 29088012. Article Request Form

Cava C, Colaprico A, Bertoli G, Graudenzi A, Silva TC, Olsen C, Noushmehr H, Bontempi G, Mauri G, and Castiglioni I. SpidermiR: An R/Bioconductor package for integrative analysis with miRNA data Int J Mol Sci 2017; 18(2)PMID: 28134831. Full Text

Chang V, Basheer A, Baumer T, Oravec D, McDonald CP, Bey MJ, Bartol S, and Yeni YN. Dynamic measurements of cervical neural foramina during neck movements in asymptomatic young volunteers Surg Radiol Anat 2017;PMID: 28343254. Full Text

Chen Z, Venkat P, Seyfried D, Chopp M, Yan T, and Chen J. Brain-heart interaction: Cardiac complications after stroke Circ Res 2017; 121(4):451-468. PMID: 28775014. Full Text

79 Dehkordi ANV, Kamali-Asl A, Wen N, Mikkelsen T, Chetty IJ, and Bagher-Ebadian H. DCE-MRI prediction of survival time for patients with glioblastoma multiforme: using an adaptive neuro-fuzzy-based model and nested model selection technique NMR Biomed 2017;PMID: 28543885. Full Text

Figueroa JM, Skog J, Akers J, Li H, Komotar R, Jensen R, Ringel F, Yang I, Kalkanis S, Thompson R, LoGuidice L, Berghoff E, Parsa A, Liau L, Curry W, Cahill D, Bettegowda C, Lang FF, Chiocca EA, Henson J, Kim R, Breakefield X, Chen C, Messer K, Hochberg F, and Carter BS. Detection of wtEGFR Amplification and EGFRvIII Mutation in CSF-Derived Extracellular Vesicles of Glioblastoma Patients Neuro Oncol 2017;PMID: 28453784. Full Text

Fullard ME, Thibault DP, Hill A, Fox J, Bhatti DE, Burack MA, Dahodwala N, Haberfeld E, Kern DS, Klepitskava OS, Urrea-Mendoza E, Myers P, Nutt J, Rafferty MR, Schwalb JM, Shulman LM, and Willis AW. Utilization of rehabilitation therapy services in Parkinson disease in the United States Neurology 2017; 89(11):1162-1169. PMID: 28835397. Full Text

Henning PT, Wilson TJ, Willsey M, John JK, Popadich M, and Yang LJ. Pilot study of intraoperative ultrasound- guided instrument placement in nerve transection surgery for peripheral nerve pain syndromes Neurosurg Focus 2017; 42(3):E6. PMID: 28245671. Full text

Holdhoff M, Ye X, Supko JG, Nabors LB, Desai AS, Walbert T, Lesser GJ, Read WL, Lieberman FS, Lodge MA, Leal J, Fisher JD, Desideri S, Grossman SA, Wahl RL, and Schiff D. Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas Neuro Oncol 2017;PMID: 28371832. Full Text

Irtenkauf SM, Sobiechowski S, Hasselbach LA, Nelson KK, Transou AD, Carlton ET, Mikkelsen T, and deCarvalho AC. Optimization of glioblastoma mouse orthotopic xenograft models for translational research Comp Med 2017; 67(4):300-314. PMID: 28830577. Full Text

Lee I. Advances in surgical approaches in glioblastoma (GBM) Chin Clin Oncol 2017; 6(4):42. PMID: 28841804. Full Text

Leeper H, Felicella MM, and Walbert T. Recent advances in the classification and treatment of ependymomas Curr Treat Options Oncol 2017; 18(9):55. PMID: 28795287. Full Text

Li L, Chopp M, Ding G, Li Q, Mahmood A, and Jiang Q. Chronic global analysis of vascular permeability and cerebral blood flow after bone marrow stromal cell treatment of traumatic brain injury in the rat: A long-term MRI study Brain Res 2017; 1675:61-70. PMID: 28899758. Full Text

Lillehei KO, Kalkanis SN, Liau LM, Mydland DE, Olson J, Paleologos NA, Ryken T, Johnson T, and Scullin E. Rationale and design of the 500-patient, 3-year, and prospective Vigilant ObservatIon of GlIadeL WAfer ImplaNT registry CNS Oncol 2017;PMID: 29206049. Full Text

Lim S, Kesavabhotla K, Cybulski GR, Dahdaleh NS, and Smith ZA. Predictors for airway complications following single- and multilevel anterior cervical discectomy and fusion Spine (Phila Pa 1976) 2017; 42(6):379-384. PMID: 27310025. Full Text

Lim S, Kesavabhotla K, Cybulski GR, Dahdaleh N, and Smith ZA. Response to the letter: Predictors for airway complications following single or multilevel anterior cervical discectomy and fusion Spine (Phila Pa 1976) 2017;PMID: 28731913. Full Text

Macki M, Uzosike A, Kerezoudis P, Bydon A, Bydon M, and Gokaslan ZL. Duration of indwelling drain following instrumented posterolateral fusion of the lumbar spine does not predict surgical site infection requiring reoperation J Clin Neurosci 2017;PMID: 28117258. Full Text

Macki M, De la Garza-Ramos R, Murgatroyd AA, Mullinix KP, Sun X, Cunningham BW, McCutcheon BA, Bydon M, and Gokaslan ZL. Comprehensive biomechanical analysis of three reconstruction techniques following total sacrectomy: an in vitro human cadaveric model J Neurosurg Spine 2017:1-8. PMID: 28777063. Full Text

Malta TM, de Souza CF, Sabedot TS, Silva TC, Mosella MQS, Kalkanis SN, Snyder J, Castro AVB, and Noushmehr H. Glioma cpg island methylator phenotype (g-cimp): Biological and clinical implications Neuro Oncol 2017;PMID: 29036500. Full Text

80 Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, and Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1 Proc Natl Acad Sci U S A 2017; 114(40):10743-10748. PMID: 28916733. Full Text

Migliara G, Mueller M, Piermattei A, Brodie C, Paidas MJ, Barnea ER, and Ria F. PIF* promotes brain re-myelination locally while regulating systemic inflammation- clinically relevant multiple sclerosis M.smegmatis model Oncotarget 2017; 8(13):21834-21851. PMID: 28423529. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400627/

Nagaraja TN, Elmghirbi R, Brown SL, Schultz LR, Lee IY, Keenan KA, Panda S, Cabral G, Mikkelsen T, and Ewing JR. Reproducibility and relative stability in magnetic resonance imaging indices of tumor vascular physiology over a period of 24h in a rat 9L gliosarcoma model Magn Reson Imaging 2017; 44:131-139. PMID: 28887206. Full Text

Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. A parametric model of the brain vascular system for estimation of the arterial input function (AIF) at the tissue level NMR Biomed 2017;PMID: 28211963. Full text

Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. An extended vascular model for less biased estimation of permeability parameters in DCE-T1 images NMR Biomed 2017;PMID: 28211961. Full text

Ning R, Venkat P, Chopp M, Zacharek A, Yan T, Cui X, Seyfried D, and Chen J. D-4F increases microRNA- 124a and reduces neuroinflammation in diabetic stroke rats Oncotarget 2017; 8(56):95481-95494. PMID: 29221142. Full Text

Noh T, Chandra R, Kim J, and Lee I. A case of symptomatic spinal dural arteriovenous fistula after high- volume lumbar puncture Surg Neurol Int 2017; 8:164. PMID: 28840068. Full Text

Rammo R, Robin A, John J, Pabaney A, Varelas P, and Kole M. Management of acute subdural hematoma in a patient with portopulmonary hypertension on prostanoid therapy Surg Neurol Int 2017; 8:161. PMID: 28840065. Full Text

Rammo R, and Schwalb JM. Comment: Is virtual reality a useful adjunct to rehabilitation after spinal cord injury? Neurology 2017; 89(18):1902. PMID: 28986413. Full Text

Reiner AT, Witwer KW, van Balkom BWM, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lotvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, and Lim SK. Concise review: Developing best- practice models for the therapeutic use of extracellular vesicles Stem Cells Transl Med 2017; 6(8):1730-1739. PMID: 28714557. Full Text

Robin AM, Lee I, and Kalkanis SN. Reoperation for recurrent glioblastoma multiforme Neurosurg Clin N Am 2017; 28(3):407-428. PMID: 28600015. Full Text

Shwartz A, Betzer O, Kronfeld N, Kazimirsky G, Cazacu S, Finniss S, Lee HK, Motiei M, Dagan SY, Popovtzer R, Brodie C, and Yadid G. Therapeutic effect of astroglia-like mesenchymal stem cells expressing glutamate transporter in a genetic rat model of depression Theranostics 2017; 7(10):2690-2703. PMID: 28819456. Request Article

Skoch J, Tahir R, Abruzzo T, Taylor JM, Zuccarello M, and Vadivelu S. Predicting symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage with an artificial neural network in a pediatric population Childs Nerv Syst 2017;PMID: 28852853. Full Text

Snyder J, Schultz L, and Walbert T. The role of tumor board conferences in neuro-oncology: a nationwide provider survey J Neurooncol 2017;PMID: 28421461. Full Text

Than KD, Mummaneni PV, Bridges KJ, Tran S, Park P, Chou D, La Marca F, Uribe JS, Vogel TD, Nunley PD, Eastlack RK, Anand N, Okonkwo DO, Kanter AS, and Mundis GM, Jr. Complication rates associated with open versus percutaneous pedicle screw instrumentation among patients undergoing minimally invasive interbody fusion for adult spinal deformity Neurosurg Focus 2017; 43(6):E7. PMID: 29191098. Full Text

81 van den Bent M, Gan HK, Lassman AB, Kumthekar P, Merrell R, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Walbert T, Scott AM, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Bain E, Ansell PJ, Holen KD, Maag D, and Reardon DA. Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study Cancer Chemother Pharmacol 2017;PMID: 29075855. Full Text

Walbert T. Palliative Care, End-of-Life Care, and Advance Care Planning in Neuro-oncology CONTINUUM Lifelong Learning in Neurology 2017; 23(6, Neuro-oncology):1709-1726. PMID: 29200118. Full Text

Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauve CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, and Verhaak RGW. Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment Cancer Cell 2017; 32(1):42-56.e46. PMID: 28697342. Request Article

Wen PY, Drappatz J, de Groot J, Prados MD, Reardon DA, Schiff D, Chamberlain M, Mikkelsen T, Desjardins A, Holland J, Ping J, Weitzman R, and Cloughesy TF. Phase II study of cabozantinib in patients with progressive glioblastoma: subset analysis of patients naive to antiangiogenic therapy Neuro Oncol 2017;PMID: 29016998. Full Text

Wharen RE, Jr., Okun MS, Guthrie BL, Uitti RJ, Larson P, Foote K, Walker H, Marshall FJ, Schwalb J, Ford B, Jankovic J, Simpson R, Dashtipour K, Phibbs F, Neimat JS, Stewart RM, Peichel D, Pahwa R, and Ostrem JL. Thalamic DBS with a constant-current device in essential tremor: A controlled clinical trial Parkinsonism Relat Disord 2017;PMID: 28400200. Full Text

Xiong Y, Mahmood A, and Chopp M. Emerging potential of exosomes for treatment of traumatic brain injury Neural Regen Res 2017; 12(1):19-22. PMID: 28250732. Full text

Zakaria H, Haider S, and Lee I. Automated whole brain tractography affects preoperative surgical decision making Cureus 2017; 9(9):e1656. PMID: 29147631. Full Text

Zhang Y, Zhang ZG, Chopp M, Meng Y, Zhang L, Mahmood A, and Xiong Y. Treatment of traumatic brain injury in rats with N-acetyl-seryl-aspartyl-lysyl-proline J Neurosurg 2017; 126(3):782-795. PMID: 28245754. Full text

NURSING

Brown-Deacon C, Brown T, Creech C, McFarland M, Nair A, and Whitlow K. Can follow-up phone calls improve patients self-monitoring of blood glucose? J Clin Nurs 2017; 26(1-2):61-67. PMID: 27862497. Full Text

Caprara J. PICC Versus Midline Home Healthc Now 2017; 35(10):575-576. PMID: 29095342. Article Request Form

Marrocco A, and Krouse HJ. Obstacles to preventive care for individuals with disability: Implications for nurse practitioners J Am Assoc Nurse Pract 2017; 29(5):282-293. PMID: 28266148. Full Text

OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES

Abdulfatah E, Sakr S, Thomas S, Al-Wahab Z, Mutch DG, Dowdy S, Bandyopadhyay S, Munkarah A, Elshaikh M, Morris R, and Ali-Fehmi R. Clear cell carcinoma of the endometrium: Evaluation of prognostic parameters in a multi- institutional cohort of 165 cases Int J Gynecol Cancer 2017; 27(8):1714-1721. PMID: 28945214. Full Text

Dar S, Chhina J, Mert I, Chitale D, Buekers T, Kaur H, Giri S, Munkarah A, and Rattan R. Bioenergetic adaptations in chemoresistant ovarian cancer cells Sci Rep 2017; 7(1):8760. PMID: 28821788. Request Article

Elshaikh MA, Vance S, Kamal M, Burmeister C, Hanna RK, Rasool N, and Siddiqui F. Influence of comorbidity on the risk of death: A single institution study of 1132 women with early-stage uterine cancer Am J Clin Oncol 2017; 40(2):183-188. PMID: 25222075. Full Text

Khalife T, and Hanna RK. The K-technique: A novel technique for laparoscopic apical suspension using barbed sutures Female Pelvic Med Reconstr Surg 2017;PMID: 28118169. Full Text

82 Lee JK, Mahan M, Hanna RK, and Elshaikh MA. Survival outcomes and patterns of failure in women with stage IIIC2 endometrial carcinoma Eur J Obstet Gynecol Reprod Biol 2017; 216:192-197. PMID: 28800504. Full Text

Lin S, McCauley EP, Lorig-Roach N, Tenney K, Naphen CN, Yang AM, Johnson TA, Hernadez T, Rattan R, Valeriote FA, and Crews P. Another look at pyrroloiminoquinone alkaloids-perspectives on their therapeutic potential from known structures and semisynthetic analogues Mar Drugs 2017; 15(4)PMID: 28353633. Full Text

Mert I, Chhina J, Allo G, Dai J, Seward S, Carey MS, Llaurado M, Giri S, Rattan R, and Munkarah AR. Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer Gynecol Oncol 2017;PMID: 28545687. Full Text

Modh A, Burmeister C, Munkarah AR, and Elshaikh MA. External pelvic and vaginal irradiation vs. vaginal irradiation alone as postoperative therapy in women with early stage uterine serous carcinoma: Results of a National Cancer Database analysis Brachytherapy 2017;PMID: 28511891. Full Text

Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, and Gerwick WH. Integrating molecular networking and biological assays to target the isolation of a cytotoxic cyclic octapeptide, samoamide a, from an american samoan marine cyanobacterium J Nat Prod 2017; 80(3):625-633. PMID: 28055219. Article Request Form

Petersen SS, Khangura R, Davydov D, Zhang Z, and Sangha R. Placental chorangiosis: Increased risk for cesarean section Case Rep Obstet Gynecol 2017; 2017:5610945. PMID: 28607782. Full Text

Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, and Boggess JF. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study Lancet Oncol 2017;PMID: 28159465. Full Text

Saeed H, Jacques SM, and Qureshi F. Meconium staining of the amniotic fluid and the presence and severity of acute placental inflammation: A study of term deliveries in a predominantly African-American population J Matern Fetal Neonatal Med 2017:1-14. PMID: 28797201. Request Article

Tsafrir Z, Aoun J, Papalekas E, Taylor A, Schiff L, Theoharis E, and Eisenstein D. Risk factors for trachelectomy following supracervical hysterectomy Acta Obstet Gynecol Scand 2017; 96(4):421-425. PMID: 28107774. Full Text

Underwood J, Fields A, Conway EM, and Chescheir NC. Connect the Dots-November 2017 Obstet Gynecol 2017; 130(5):1155-1156. PMID: 29016502. Full Text

Wahid M, Akhter N, Jawed A, Dar SA, Mandal RK, Lohani M, Areeshi MY, Khan S, and Haque S. Pembrolizumab's non-cross resistance mechanism of action successfully overthrown ipilimumab Crit Rev Oncol Hematol 2017; 111:1-6. PMID: 28259284. Full text

Wei X, Shi B, Koo I, Yin X, Lorkiewicz P, Suhail H, Rattan R, Giri S, McClain CJ, and Zhang X. Analysis of stable isotope assisted metabolomics data acquired by GC-MS Anal Chim Acta 2017; 980:25-32. PMID: 28622800. Article Request Form

Winer I, Patel D, Dalton V, Johnston C, Quint EH, Zochowski M, Munkarah A, Morris R, and Haefner H. Involvement and comfort of gynecologic oncologists in the treatment of pediatric, adolescent, and young adult patients with gynecologic malignancies Int J Gynaecol Obstet 2017;PMID: 28485838. Full Text

Xia H, Wang W, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, and Zou W. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naive T cell apoptosis and affects tumor immunity Sci Immunol 2017; 2(17)PMID: 29150439. Article Request Form

Zhang M, Goyert G, and Lim HW. Folate and phototherapy: What should we inform our patients? J Am Acad Dermatol 2017; 77(5):958-964. PMID: 29029903. Full Text

Zwain O, Aoun J, and Eisenstein D. Minimally invasive surgery in pelvic floor repair Curr Opin Obstet Gynecol 2017;PMID: 28594646. Full Text

83 OPTHALMOLOGY AND EYE CARE SERVICES

Ahn JH, Choi SJ, Im M, Kim S, Kim CH, Kim JY, Park TJ, Lee SY, and Choi YK. Charge and dielectric effects of biomolecules on electrical characteristics of nanowire FET biosensors Appl Phys Lett 2017; 111(11):5. PMID: Not assigned. Article Request Form

Ehrlich JR, Wentzloff JN, Imami NR, Blachley TS, Stein JD, Lee PP, and Weizer JS. Establishing a regional glaucoma physician collaborative to improve quality of care Am J Ophthalmol 2017;PMID: 28483494. Full Text

Peracha-Riyaz MH, Peracha ZH, Spaulding J, Baciu P, Ahmed S, Imami NR, Darnley-Fisch D, and Desai U. First described case of anterior and posterior segment crystals in phacolytic glaucoma J Glaucoma 2017;PMID: 28234682. Full text

Sangave A, Komati R, Weinmann A, Samuel L, and Desai U. Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis Am J Ophthalmol Case Rep 2017; 7:149-152. PMID: 29260103. Full Text

ORTHOPAEDICS/BONE AND JOINT

Basheer A, Macki M, Buraimoh M, and Mahmood A. Chronic thoracolumbar subdural empyema: Case report and surgical management Surg Neurol Int 2017; 8:167. PMID: 28840071. Full Text

Baumer TG, Davis L, Dischler J, Siegal DS, van Holsbeeck M, Moutzouros V, and Bey MJ. Shear wave elastography of the supraspinatus muscle and tendon: Repeatability and preliminary findings J Biomech 2017;PMID: 28110933. Full Text

Baumer TG, Dischler J, Mende V, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of asymptomatic rotator cuff pathology on in vivo shoulder motion and clinical outcomes J Shoulder Elbow Surg 2017;PMID: 28131679. Full Text

Buraimoh MA, Liu JZ, Sundberg SB, and Mott MP. Eponymous instruments in orthopaedic surgery Iowa Orthop J 2017; 37:211-217. PMID: 28852360. Full Text

Buraimoh MA, Massie LW, and Montgomery DM. Lateral atlantoaxial osteoarthritis: A narrative literature review Clin Spine Surg 2017; 30(10):433-438. PMID: 29088012. Article Request Form

Buraimoh MA, Yu CC, Mott MP, and Graziano GP. Sacroiliac stabilization for sacral metastasis: A case series Surg Neurol Int 2017; 8:287. PMID: 29285403. Full Text

Burnham JM, Meta F, Lizzio V, Makhni EC, and Bozic KJ. Technology assessment and cost-effectiveness in orthopedics: how to measure outcomes and deliver value in a constantly changing healthcare environment Curr Rev Musculoskelet Med 2017;PMID: 28421386. Full Text

Chang V, Basheer A, Baumer T, Oravec D, McDonald CP, Bey MJ, Bartol S, and Yeni YN. Dynamic measurements of cervical neural foramina during neck movements in asymptomatic young volunteers Surg Radiol Anat 2017;PMID: 28343254. Full Text

Cvetanovich GL, Lizzio V, Meta F, Chan D, Zaltz I, Nho SJ, and Makhni EC. Variability and comprehensiveness of north american online available physical therapy protocols following hip arthroscopy for femoroacetabular impingement and labral repair Arthroscopy 2017; 33(11):1998-2005. PMID: 28969949. Full Text

Dischler JD, Baumer TG, Finkelstein E, Siegal DS, and Bey MJ. Association between years of competition and shoulder function in collegiate swimmers Sports Health 2017:1941738117726771. PMID: 28829699. Full Text

Endicott J, Holden P, and Fitzgerald J. Authentication of collagen VI antibodies BMC Res Notes 2017; 10(1):358. PMID: 28755659. Full Text

Fitzgerald J. Enhanced cartilage repair in 'healer' mice-New leads in the search for better clinical options for cartilage repair Semin Cell Dev Biol 2017; 62:78-85. PMID: 27130635. Full Text

Francis T, Washington T, Srivastava K, Moutzouros V, Makhni EC, and Hakeos W. Societal costs in displaced transverse olecranon fractures: using decision analysis tools to find the most cost-effective strategy between tension band wiring and locked plating J Shoulder Elbow Surg 2017; 26(11):1995-2003. PMID: 28927668. Full Text

84 Frisch NB, Wessell NM, Taliaferro K, Van Holsbeeck M, and Silverton CD. Ultrasound findings in asymptomatic patients with modular metal on metal total hip arthroplasty Skeletal Radiol 2017;PMID: 28204856. Full text

Frisch NB, Nahm NJ, Khalil JG, Les CM, Guthrie ST, and Charters MA. Short versus long cephalomedullary nails for pertrochanteric hip fracture Orthopedics 2017; 40(2):83-88. PMID: 27874910. Article Request Form

Frisch NB, Kadri OM, Tenbrunsel T, Abdul-Hak A, Qatu M, and Davis JJ. Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty Arthroplast Today 2017;PMID: Not assigned. Full Text

Frisch NB, Lynch JR, Banglmaier RF, and Silverton CD. The stability of dual-taper modular hip implants: a biomechanical analysis examining the effect of impact location on component stability Arthroplast Today 2017; 3(2):119-124. PMID: 28695184. Full Text

Frisch NB, Kadri OM, Tenbrunsel T, Abdul-Hak A, Qatu M, and Davis JJ. Intraoperative chlorhexidine irrigation to prevent infection in total hip and knee arthroplasty Arthroplast Today 2017; 3(4):294-297. PMID: 29204500. Full Text

Georgiadis AG, Rossow JK, Laine JC, Iobst CA, and Dahl MT. Plate-assisted lengthening of the femur and tibia in pediatric patients J Pediatr Orthop 2017; 37(7):473-478. PMID: 26368858. Full Text

Gibson GJ, and Yang M. What rheumatologists need to know about CRISPR/Cas9 Nat Rev Rheumatol 2017;PMID: 28202911. Article request form

Jacobs CA, Burnham JM, Makhni E, Malempati CS, Swart E, and Johnson DL. Allograft augmentation of hamstring autograft for younger patients undergoing anterior cruciate ligament reconstruction Am J Sports Med 2017; 45(4):892-899. PMID: 28298052. Full Text

Jasinski MJ, Lumley MA, and Mandel S. Patient factors in decision-making for orthopaedic surgery: A prospective analysis Curr Orthop Pract 2017; 28(3):287-292. PMID: Not assigned. Full Text

Keller RA, Mehran N, Marshall NE, Okoroha KR, Khalil L, Tibone JE, and Moutzouros V. Major League pitching workload after primary ulnar collateral ligament reconstruction and risk for revision surgery J Shoulder Elbow Surg 2017; 26(2):288-294. PMID: 28104091. Full Text

Kim W, Oravec D, Divine GW, Flynn MJ, and Yeni YN. Effect of view, scan orientation and analysis volume on digital tomosynthesis (dts) based textural analysis of bone Ann Biomed Eng 2017;PMID: 28083858. Full Text

Kuhns BD, Hannon CP, Makhni EC, Alter J, Mather RC, 3rd, Salata MJ, and Nho SJ. A comparison of clinical outcomes after unilateral or bilateral hip arthroscopic surgery: Age- and sex-matched cohort study Am J Sports Med 2017:363546517719020. PMID: 28820272. Full Text

Li B, Singer N, Rosenthal A, Unal M, Haggins D, Yeni YN, and Akkus O. Chemical characterization of Maltese-cross birefringent particles in synovial fluid samples collected from symptomatic joints Joint Bone Spine 2017;PMID: 28965940. Full Text

Lizzio VA, Meta F, Fidai M, and Makhni EC. Clinical evaluation and physical exam findings in patients with anterior shoulder instability Curr Rev Musculoskelet Med 2017;PMID: 29043566. Full Text

Makhni EC, Meadows M, Hamamoto JT, Higgins JD, Romeo AA, and Verma NN. Patient reported outcomes measurement information system (promis) in the upper extremity: The future of outcomes reporting? J Shoulder Elbow Surg 2017; 26(2):352-357. PMID: 28104094. Full Text

Makhni EC, Hamamoto JT, Higgins JD, Patterson T, Griffin JW, Romeo AA, and Verma NN. How comprehensive and efficient are patient-reported outcomes for rotator cuff tears? Orthop J Sports Med 2017; 5(3):2325967117693223. PMID: 28451596. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400217/

Makhni EC, Stone AV, Ukwuani GC, Zuke W, Garabekyan T, Mei-Dan O, and Nho SJ. A critical review: Management and surgical options for articular defects in the hip Clin Sports Med 2017; 36(3):573-586. PMID: 28577713. Full Text

Makhni EC, Higgins JD, Hamamoto JT, Cole BJ, Romeo AA, and Verma NN. Patient compliance with electronic patient reported outcomes following shoulder arthroscopy Arthroscopy 2017; 33(11):1940-1946. PMID: 28958797. Full Text

85 Newman JM, George J, North WT, Navale SM, Klika AK, Barsoum WK, and Higuera CA. Hematologic malignancies are associated with adverse perioperative outcomes after total hip arthroplasty J Arthroplasty 2017;PMID: 28372919. Full Text

Okoroha KR, Kadri O, Keller RA, Marshall N, Cizmic Z, and Moutzouros V. Return to play after revision anterior cruciate ligament reconstruction in national football league players Orthop J Sports Med 2017; 5(4):2325967117698788. PMID: 28451611. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400221/

Okoroha KR, Gabbard MD, 2nd, Fitts J, and Banka TR. Cutibacteriumacnes septic arthritis of the nonoperated knee: A case report Surg J (N Y) 2017; 3(3):e107-e109. PMID: 28825032. Full Text

Okoroha KR, Marfo K, Meta F, Matar R, Shehab R, Thompson T, Moutzouros V, and Makhni EC. Amount of minutes played does not contribute to anterior cruciate ligament injury in national basketball association athletes Orthopedics 2017; 40(4):e658-e662. PMID: 28481383. Available in print at Sladen, Please contact the library for assistance

Radzak KN, Putnam AM, Tamura K, Hetzler RK, and Stickley CD. Asymmetry between lower limbs during rested and fatigued state running gait in healthy individuals Gait Posture 2017; 51:268-274. PMID: 27842295. Full Text

Shukla M, Keller R, Marshall N, Ahmed H, Scher C, Moutzouros VB, and van Holsbeeck M. Ultrasound evaluation of the ulnar collateral ligament of the elbow: Which method is most reproducible? Skeletal Radiol 2017;PMID: 28424849. Full Text

Slotkin S, Frisch NB, Roc G, and Silverton CD. Hemispherical and minimally invasive total hip reamers: a biomechanical analysis of use and design Arthroplast Today 2017; 3(2):131-136. PMID: 28695186. Full Text

Stone AV, Jacobs CA, Luo TD, Meadows MC, Nho SJ, Stubbs AJ, and Makhni EC. High degree of variability in reporting of clinical and patient-reported outcomes after hip arthroscopy Am J Sports Med 2017:363546517724743. PMID: 28922016. Full Text

Trofa DP, Gancarczyk SM, Lombardi JM, Makhni EC, Popkin CA, and Ahmad CS. Visualization of the capitellum during elbow arthroscopy: A comparison of 3 portal techniques Orthop J Sports Med 2017; 5(6):2325967117712228. PMID: 28680895. Full Text

Vasileff WK, Nekhline M, Kolowich PA, Talpos GB, Eyler WR, and van Holsbeeck M. Inguinal hernia in athletes: Role of dynamic ultrasound Sports Health 2017:1941738117717009. PMID: 28732177. Full Text

OTOLARYNGOLOGY – HEAD AND NECK SURGERY

Arden RL, and Miller LK. Application of trotter approach for large intralingual thyroglossal duct cyst in an 88-year- old patient J Oral Maxillofac Surg 2017;PMID: 28284788. Full Text

Arora S, Campbell L, Tourojman M, Pucheril D, Jones LR, and Rogers C. Robotic buccal mucosal graft ureteroplasty for complex ureteral stricture Urology 2017; 110:257-258. PMID: 29153902. Full Text

Bokhari M, and Greene J. Adenoma, parotid, pleomorphic StatPearls 2017;PMID: 28613579. Full Text book chapter

Chin-Quee AL, and Yaremchuk K. Medical residents' circadian preferences across specialties Laryngoscope 2017;PMID: 28722202. Full Text

Craig JR, Palmer JN, and Zhao K. Computational fluid dynamic modeling of nose-to-ceiling head positioning for sphenoid sinus irrigation Int Forum Allergy Rhinol 2017;PMID: 28092136. Article Request Form

Greene J, and Al-Dhahir MA. Acoustic Neuroma (Vestibular Schwannoma) StatPearls 2017;PMID: 29262098. Full Text

Iwata AJ, Williams AM, Taylor AR, and Chang SS. Socioeconomic disparities and comorbidities, not race, affect salivary gland malignancy survival outcomes Laryngoscope 2017;PMID: 28498500. Full Text

Kandinov A, Smith M, and Ahsan SF. Middle ear mass causing vertigo and facial nerve weakness JAMA Otolaryngol Head Neck Surg 2017;PMID: 28056134. Full Text

86 Komorowska-Timek E, Turfe Z, and Davis AT. Outcomes of prosthetic reconstruction of irradiated and nonirradiated breasts with fat grafting Plast Reconstr Surg 2017; 139(1):1e-9e. PMID: 28027220. Full Text

Komorowska-Timek E, Turfe Z, and Davis AT. Reply: Outcomes of prosthetic reconstruction of irradiated and nonirradiated breasts with fat grafting Plast Reconstr Surg 2017; 140(3):497e-499e. PMID: 28590985. Full Text

Miller AJ, and Gardner GM. In-office vs. operating room procedures for recurrent respiratory papillomatosis Ear Nose Throat J 2017; 96(4-5):E24-e28. PMID: 28489241. Full Text

Seidman MD, Wertz AG, Smith MM, Jacob S, and Ahsan SF. Evaluation of noise exposure secondary to wind noise in cyclists Otolaryngol Head Neck Surg 2017:194599817715250. PMID: 28742424. Full Text

Smith MM, Peterson E, and Yaremchuk KL. The role of tonsillectomy in adults with tonsillar hypertrophy and obstructive sleep apnea Otolaryngol Head Neck Surg 2017:194599817698671. PMID: 28349770. Full Text Swegal WC, Chang SS, and Singer MC. Referral trends for surgical management of graves' disease Thyroid 2017;PMID: 28699420. Full Text

Williams AM, Lindholm J, Siddiqui F, Ghanem TA, and Chang SS. Clinical assessment of cognitive function in patients with head and neck cancer: Prevalence and correlates Otolaryngol Head Neck Surg 2017:194599817709235. PMID: 28585482. Full Text

Williams AM, Lindholm J, Cook D, Siddiqui F, Ghanem TA, and Chang SS. Association between cognitive function and quality of life in patients with head and neck cancer JAMA Otolaryngol Head Neck Surg 2017;PMID: 29121151. Full Text

Yaremchuk K. USPSTF recommendation for obstructive sleep apnea screening in adults JAMA Otolaryngol Head Neck Surg 2017;PMID: 28118426. Full Text

Yaremchuk K, Darian V, and Williams AM. Seasonality of auricular amputations in rabbits Laryngoscope 2017; 127(4):773-775. PMID: 28322456. Full Text

PATHOLOGY

Banks P, Brown R, Laslowski A, Daniels Y, Branton P, Carpenter J, Zarbo R, Forsyth R, Liu YH, Kohl S, Diebold J, Masuda S, Plummer T, and Dennis E. A proposed set of metrics to reduce patient safety risk from within the anatomic pathology laboratory Lab Med 2017;PMID: 28340232. Full Text

Basheer A, Rammo R, Kalkanis S, Felicella MM, and Chedid M. Multifocal intradural extramedullary pilocytic astrocytomas of the spinal cord: A case report and review of the literature Neurosurgery 2017; 80(2):E178-e184. PMID: 28173580. Full text

Calio A, Eble JN, Hes O, Martignoni G, Harari SE, Williamson SR, Brunelli M, Osunkoya AO, Wang L, Comperat E, Lopez-Beltran A, Wang M, Zhang S, Curless KL, Post KM, Chang HY, Luchini C, Baldrige LA, MacLennan GT, Montironi R, Grignon DJ, and Cheng L. Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation Oncotarget 2017; 8(33):54096-54105. PMID: 28903326. Full Text

Clarke LE, Pimentel JD, Zalaznick H, Wang L, and Busam KJ. Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma Hum Pathol 2017;PMID: 29079183. Full Text

Cohen D, Allen TC, Balci S, Cagle PT, Teruya-Feldstein J, Fine SW, Gondim DD, Hunt JL, Jacob J, Jewett K, Jiang X, Kaplan KJ, Kulac I, Meunier R, Riddle ND, Rush PS, Stall J, Stuart LN, Terrano D, Uthman E, Wasco MJ, Williamson SR, Wu RI, and Gardner JM. #InSituPathologists: how the #USCAP2015 meeting went viral on Twitter and founded the social media movement for the United States and Canadian Academy of Pathology Mod Pathol 2017; 30(2):160-168. PMID: 28084341. Full Text

Crawford JM, Shotorbani K, Sharma G, Crossey M, Kothari T, Lorey TS, Prichard JW, Wilkerson M, and Fisher N. Improving american healthcare through "clinical lab 2.0": A project santa fe report Acad Pathol 2017; 4:2374289517701067. PMID: 28725789. Full Text

Dar S, Chhina J, Mert I, Chitale D, Buekers T, Kaur H, Giri S, Munkarah A, and Rattan R. Bioenergetic adaptations in chemoresistant ovarian cancer cells Sci Rep 2017; 7(1):8760. PMID: 28821788. Request Article

87 Datta L, and Menon MP. Plasmacytoid lymphocytes: a clue to dengue diagnosis Blood 2017; 129(15):2202. PMID: 28408424. Full Text

Favazza L, Chitale DA, Barod R, Rogers CG, Kalyana-Sundaram S, Palanisamy N, Gupta NS, and Williamson SR. Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database Mod Pathol 2017;PMID: 28731045. Full Text

Flynt LK, Veve MP, Samuel LP, and Tibbetts RJ. Comparison of etest to broth microdilution for testing of susceptibility of pseudomonas aeruginosa to ceftolozane-tazobactam J Clin Microbiol 2017; 55(1):334-335. PMID: 27795348. Article Request Form

Go P, Watson J, Lu Z, Carlin A, and Hammoud Z. Robotic resection of a mediastinal parathyroid cyst Gen Thorac Cardiovasc Surg 2017; 65(1):52-55. PMID: 26353995. Full Text

Jamal M, Rayes O, Samuel L, Tibbetts R, and Pimentel JD. Closing the brief case: Benign rectal polyp with schistosoma mansoni J Clin Microbiol 2017; 55(4):1226-1227. PMID: 28341803. Article Request Form

Jamal M, Rayes O, Samuel L, Tibbetts R, and Pimentel JD. The brief case: Benign rectal polyp with schistosoma mansoni J Clin Microbiol 2017; 55(4):992-995. PMID: 28341802. Article Request Form

Kahlon PS, Mishra A, Williams TR, Sandhu NK, Donthireddy V, and Dobrostoskaya I. Diagnosing primary squamous cell cancer of the rectum in a patient with hiv: A case report J Oncol Pract 2017:Jop2016019901. PMID: 28557660. Article Request Form

Karner KH, and Inamdar KV. Plasma cell myeloma mimicking classical Hodgkin lymphoma in the bone marrow Int J Hematol 2017;PMID: 29027630. Full Text

Khurram MS, Shaikh H, Khan U, Edens J, Ibrar W, Hamza A, Zaka A, Bano R, and Hadid T. Benign multicystic peritoneal mesothelioma: A rare condition in an uncommon gender Case Rep Pathol 2017; 2017:9752908. PMID: 28607791. Full Text

Leeper H, Felicella MM, and Walbert T. Recent advances in the classification and treatment of ependymomas Curr Treat Options Oncol 2017; 18(9):55. PMID: 28795287. Full Text

Lin T, Lin D, Zhang Z, and Shah BA. Metastatic endometrial serous carcinoma to the breast Appl Radiol 2017; 46(11):42-45. PMID: Not assigned. Article Request Form

Liquete E, Williamson SR, Janakiraman N, and Venkat KK. Renal complications of hematopoietic stem cell transplantation: Report of a case and review of the literature Indian J Nephrol 2017; 27(6):468-471. PMID: 29217887. Full Text

Loudig O, Wang T, Ye K, Lin J, Wang Y, Ramnauth A, Liu C, Stark A, Chitale D, Greenlee R, Multerer D, Honda S, Daida Y, Spencer Feigelson H, Glass A, Couch FJ, Rohan T, and Ben-Dov IZ. Evaluation and adaptation of a laboratory-based cdna library preparation protocol for retrospective sequencing of archived micrornas from up to 35- year-old clinical ffpe specimens Int J Mol Sci 2017; 18(3)PMID: 28335433. Full Text

Mert I, Chhina J, Allo G, Dai J, Seward S, Carey MS, Llaurado M, Giri S, Rattan R, and Munkarah AR. Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer Gynecol Oncol 2017;PMID: 28545687. Full Text

Otrock ZK, Liu C, and Grossman BJ. Transfusion-related acute lung injury risk mitigation: an update Vox Sang 2017;PMID: 28948604. Full Text

Pagano MB, Wehrli G, Cloutier D, Galvin Karr E, Lopez-Plaza I, Schwartz J, Andrzejewski C, Winters JL, Wong EC, Wu Y, and Zantek ND. Apheresis medicine education in the united states of america: State of the discipline Transfus Apher Sci 2017; 56(1):1-5. PMID: 28089411. Full Text

Petersen SS, Khangura R, Davydov D, Zhang Z, and Sangha R. Placental chorangiosis: Increased risk for cesarean section Case Rep Obstet Gynecol 2017; 2017:5610945. PMID: 28607782. Full Text

Rundle A, Wang Y, Sadasivan S, Chitale DA, Gupta NS, Tang D, and Rybicki BA. Larger men have larger prostates: Detection bias in epidemiologic studies of obesity and prostate cancer risk Prostate 2017;PMID: 28349547.

88 Samuel L, and Plebani M. Targeting errors in microbiology: the case of the Gram stain Clin Chem Lab Med 2017; 55(3):309-310. PMID: 27718489. Full text

Sanfrancesco J, Williamson SR, Kum JB, Zhang S, Wang M, Lopez-Beltran A, Montironi R, Gardner TA, and Cheng L. Mullerian adenosarcoma of the urinary bladder: Clinicopathologic and immunohistochemical features with novel genetic aberrations Clin Genitourin Cancer 2017;PMID: 28690098. Full Text

Sangave A, Komati R, Weinmann A, Samuel L, and Desai U. Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis Am J Ophthalmol Case Rep 2017; 7:149-152. PMID: 29260103. Full Text

Sharma G, and Carter A. Artificial intelligence and the pathologist: Future frenemies? Arch Pathol Lab Med 2017; 141(5):622-623. PMID: 28447905. Full Text

Sirohi D, Smith SC, Epstein JI, Balzer BL, Simko JP, Balitzer D, Benhamida J, Kryvenko ON, Gupta NS, Paluru S, da Cunha IW, Leal DN, Williamson SR, de Peralta-Venturina M, and Amin MB. Pericytic tumors of the kidney - a clinicopathologic analysis of 17 cases Hum Pathol 2017;PMID: 28438616. Full Text

Stephen JK, Chen KM, Merritt J, Chitale D, Divine G, and Worsham MJ. Methylation markers differentiate thyroid cancer from benign nodules J Endocrinol Invest 2017;PMID: 28612287. Article Request Form

Takahashi K, Go P, Stone CH, Safwan M, Putchakayala KG, Kane WJ, Malinzak LE, Kim DY, and Denny JE. Mycophenolate mofetil and pulmonary fibrosis after kidney transplantation: A case report Am J Case Rep 2017; 18:399-404. PMID: 28408734. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398249/

Wang X, Lopez-Beltran A, Osunkoya AO, Wang M, Zhang S, Davidson DD, Emerson RE, Williamson SR, Tan PH, Kaimakliotis HZ, Baldridge LA, MacLennan GT, Montironi R, and Cheng L. TERT promoter mutation status in sarcomatoid urothelial carcinomas of the upper urinary tract Future Oncol 2017;PMID: 28052688. Article Request Form

Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Priya Kunju L, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, and Gupta NS. Diagnostic criteria for oncocytic renal neoplasms: A survey of urologic pathologists Hum Pathol 2017;PMID: 28315424. Full Text

Williamson SR, Grignon DJ, Calio A, Stohr BA, Eble JN, and Cheng L. Reply to Chou et al 'Do significant TFE3 gene rearrangements occur in succinate dehydrogenase deficient renal cell carcinoma? Borderline FISH results should be interpreted with caution' Mod Pathol 2017; in press Mod Pathol 2017; 30(10):1509-1511. PMID: 28972584. Full Text

Zarbo RJ, Copeland JR, and Varney RC. Deviation management: Key management subsystem driver of knowledge-based continuous improvement in the henry ford production system Am J Clin Pathol 2017; 148(4):354-367. PMID: 28967954. Full Text

PEDIATRICS

Kulik NL, Thomas EM, Iovan S, McKeough M, Kendzierski S, and Leatherwood S. Access to primary care child weight management programs: Urban parent barriers and facilitators to participation J Child Health Care 2017; 21(4):509-521. PMID: 29110523. Full Text

Shires DA, Schnaar A, Connolly MD, and Stroumsa D. To refer or not to refer: General pediatricians' perspectives on their role in caring for transgender youth Transgender Health 2017; 2(1):202-206. PMID: 29177196. Full Text

PHARMACY

Athans V, Veve MP, and Davis SL. Trowels and tribulations: Review of antimicrobial-impregnated bone cements in prosthetic joint surgery Pharmacotherapy 2017;PMID: 28976593. Full Text

Awdish RL, Mendez MP, MacDonald N, Yessayan L, Jennings JH, Albujoq K, Hegab S, and Cajigas HR. Low rate of adverse events associated with inpatient parenteral prostacyclins J Healthc Qual 2017; 39(5):e84-e90. PMID: 27631708. Article Request Form

89 Farhan S, Bazydlo M, Neme K, Mikulandric N, Peres E, and Janakiraman N. Chimerism in myeloid malignancies following stem cell transplantation using flubu4 with and without busulfan pharmacokinetics versus bucy Adv Hematol 2017; 2017:8690416. PMID: 29250116. Full Text

Flynt LK, Veve MP, Samuel LP, and Tibbetts RJ. Comparison of etest to broth microdilution for testing of susceptibility of pseudomonas aeruginosa to ceftolozane-tazobactam J Clin Microbiol 2017; 55(1):334-335. PMID: 27795348. Article Request Form

Flynt LK, Kenney RM, Zervos MJ, and Davis SL. The safety and economic impact of cefazolin versus nafcillin for the treatment of methicillin-susceptible staphylococcus aureus bloodstream infections Infect Dis Ther 2017;PMID: 28265972. Article Request Form

Pathak RD, Schroeder EB, Seaquist ER, Zeng C, Lafata JE, Thomas A, Lawrence JM, Karter AJ, Steiner JF, Segal J, and O'Connor PJ. Response to comment on pathak et al. Severe hypoglycemia requiring medical intervention in a large cohort of adults with diabetes receiving care in u.S. Integrated health care delivery systems: 2005-2011. Diabetes care 2016;39:363-370 Diabetes Care 2017; 40(2):e26. PMID: 28108542. Full Text

Riha HM, Summers BB, Rivera JV, and Van Berkel MA. Novel therapies for angiotensin-converting enzyme inhibitor- induced angioedema: A systematic review of current evidence J Emerg Med 2017;PMID: 28939396. Full Text

Smith AL, Palmer V, Farhat N, Kalus JS, Thavarajah K, Digiovine B, and Macdonald NC. Hospital-based clinical pharmacy services to improve ambulatory management of chronic obstructive pulmonary disease J Pharm Technol 2017; 33(1):8-14. PMID: Not assigned. Full Text

Smith ZR, Makowski CT, and MacDonald NC. Inpatient pharmacy experience with an audit for a risk evaluation and mitigation strategy for riociguat Am J Health Syst Pharm 2017; 74(21):1762-1763. PMID: 29070497. Full Text

Starosta K, Davis SL, Kenney RM, Peters M, To L, and Kalus JS. Creating objective and measurable postgraduate year 1 residency graduation requirements Am J Health Syst Pharm 2017; 74(6):389-396. PMID: 28274981. Full Text

Suleyman G, Grunwald J, Kenney RM, Davis SL, Zervos MJ, and Weinmann A. Impact of antimicrobial stewardship consultation service at an academic institution Infect Dis Clin Pract 2017; 25(5):268-271. PMID: Not assigned. Full Text

Tarantino MD, and Pindolia VK. Hemophilia management via data collection and reporting: Initial findings from the comprehensive care sustainability collaborative J Manag Care Spec Pharm 2017; 23(1):51-56. PMID: 28025929. Full Text

Trinh TD, Zasowski EJ, Claeys KC, Lagnf AM, Kidambi S, Davis SL, and Rybak MJ. Multidrug-resistant Pseudomonas aeruginosa lower respiratory tract infections in the intensive care unit: Prevalence and risk factors Diagn Microbiol Infect Dis 2017;PMID: 28716451. Full Text

Tsivgoulis G, Lioutas VA, Varelas P, Katsanos AH, Goyal N, Mikulik R, Barlinn K, Krogias C, Sharma VK, Vadikolias K, Dardiotis E, Karapanayiotides T, Pappa A, Zompola C, Triantafyllou S, Kargiotis O, Ioakeimidis M, Giannopoulos S, Kerro A, Tsantes A, Mehta C, Jones M, Schroeder C, Norton C, Bonakis A, Chang J, Alexandrov AW, Mitsias P, and Alexandrov AV. Direct oral anticoagulant- vs vitamin K antagonist-related nontraumatic intracerebral hemorrhage Neurology 2017;PMID: 28814457. Full Text

Wong A, Erdman M, Hammond DA, Holt T, Holzhausen JM, Horng M, Huang LL, Jarvis J, Kram B, Kram S, Lesch C, Mercer J, Rech MA, Rivosecchi R, Stump B, Teevan C, and Day S. Major publications in the critical care pharmacotherapy literature in 2015 Am J Health Syst Pharm 2017;PMID: 28122702. Full Text

Zhang L, Chopp M, Lu M, Zhang T, Li C, Winter S, Brandstaetter H, Doppler E, Meier D, Pabla P, and Zhang ZG. Demonstration of therapeutic window of Cerebrolysin in embolic stroke: A prospective, randomized, blinded, and placebo-controlled study Int J Stroke 2017:1747493017702665. PMID: 28382851. Article Request Form

PUBLIC HEALTH SCIENCES

Ahmedani BK, Peterson EL, Hu Y, Rossom RC, Lynch F, Lu CY, Waitzfelder BE, Owen-Smith AA, Hubley S, Prabhakar D, Williams LK, Zeld N, Mutter E, Beck A, Tolsma D, and Simon GE. Major physical health conditions and risk of suicide Am J Prev Med 2017;PMID: 28619532. Full Text

90 Alexander GL, Dixit-Joshi S, Kushi LH, Coleman LA, Sundaram ME, Clancy HA, Groesbeck M, Potischman NA, Kirkpatrick SI, Zimmerman TP, George SM, Subar AF, and Thompson FE. Comparison of recruitment and retention among demographic subgroups in a large diverse population study of diet Contemp Clin Trials Commun 2017; 6:140- 146. PMID: 28752133. Full Text

Alexander GL, Olden HA, Troy T, Miree CA, and Joseph CLM. Overweight adolescents and asthma: Revealing motivations and challenges with adolescent-provider communication J Asthma 2017:1-9. PMID: 28562121. Full Text

Alford SH, Divine G, Chao C, Habel LA, Janakiraman N, Wang Y, Feigelson HS, Scholes D, Roblin D, Epstein MM, Engel L, Havstad S, Wells K, Yood MU, Fortuny J, and Johnson CC. Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis Cancer Causes Control 2017;PMID: 29192350. Full Text

Basheer A, Alsaidi M, Schultz L, Chedid M, Abdulhak M, and Seyfried D. Preventive effect of tamsulosin on postoperative urinary retention in neurosurgical patients Surg Neurol Int 2017; 8:75. PMID: 28584678. Full Text

Baumer TG, Dischler J, Mende V, Zauel R, van Holsbeeck M, Siegal DS, Divine G, Moutzouros V, and Bey MJ. Effects of asymptomatic rotator cuff pathology on in vivo shoulder motion and clinical outcomes J Shoulder Elbow Surg 2017;PMID: 28131679. Full Text

Boggs JM, Simon GE, Ahmedani BK, Peterson E, Hubley S, and Beck A. The association of firearm suicide with mental illness, substance use conditions, and previous suicide attempts Ann Intern Med 2017;PMID: 28672343. Full Text

Boscarino JA, Moorman AC, Rupp LB, Zhou Y, Lu M, Teshale EH, Gordon SC, Spradling PR, Schmidt MA, Trinacty CM, Zhong Y, Holmberg SD, and Holtzman D. Comparison of icd-9 codes for depression and alcohol misuse to survey instruments suggests these codes should be used with caution Dig Dis Sci 2017; 62(10):2704- 2712. PMID: 28879547. Full Text

Boyce-Fappiano D, Elibe E, Schultz L, Ryu S, Siddiqui MS, Chetty I, Lee I, Rock J, Movsas B, and Siddiqui F. Analysis of the factors contributing to vertebral compression fractures after spine stereotactic radiosurgery Int J Radiat Oncol Biol Phys 2017; 97(2):236-245. PMID: 28068232. Full Text

Brodie S, Kyung Lee H, Jiang W, Cazacu S, Xiang C, Poisson LM, Datta I, Kalkanis S, Ginsberg D, and Brodie C. The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells Oncotarget 2017;PMID: 28423669. http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=15991&pu b med-linkout=1

Cassidy-Bushrow AE, Sitarik AR, Havstad S, Park SK, Bielak LF, Austin C, Johnson CC, and Arora M. Burden of higher lead exposure in African-Americans starts in utero and persists into childhood Environ Int 2017; 108:221-227. PMID: 28886415. Article Request Form

Conti DV, Wang K, Sheng X, Bensen JT, Hazelett DJ, Cook MB, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Stanford JL, Zheng W, Sanderson M, John EM, Park JY, Xu J, Stevens VL, Berndt SI, and Haiman CA. Two novel susceptibility loci for prostate cancer in men of African Ancestry J Natl Cancer Inst 2017; 109(8)PMID: 29117387. Full Text

Drake CL, Durrence H, Cheng P, Roth T, Pillai V, Peterson EL, Singh M, and Tran KM. Arousability and fall risk during forced awakenings from nocturnal sleep among healthy males following administration of zolpidem 10 mg and doxepin 6 mg: A randomized, placebo-controlled, four-way crossover trial Sleep 2017;PMID: 28575467. Full Text

Elshaikh MA, Vance S, Kamal M, Burmeister C, Hanna RK, Rasool N, and Siddiqui F. Influence of comorbidity on the risk of death: A single institution study of 1132 women with early-stage uterine cancer Am J Clin Oncol 2017; 40(2):183-188. PMID: 25222075. Full Text

Epstein MM, Divine G, Chao CR, Wells KE, Feigelson HS, Scholes D, Roblin D, Yood MU, Engel LS, Taylor A, Fortuny J, Habel LA, and Johnson CC. Statin use and risk of multiple myeloma: An analysis from the Cancer Research Network Int J Cancer 2017;PMID: 28425616. Full Text

Farhan S, Bazydlo M, Neme K, Mikulandric N, Peres E, and Janakiraman N. Chimerism in myeloid malignancies following stem cell transplantation using flubu4 with and without busulfan pharmacokinetics versus bucy Adv Hematol 2017; 2017:8690416. PMID: 29250116. Full Text

91 Fonseca W, Lucey K, Jang S, Fujimura KE, Rasky A, Ting HA, Petersen J, Johnson CC, Boushey HA, Zoratti E, Ownby DR, Levine AM, Bobbit KR, Lynch SV, and Lukacs NW. Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation Mucosal Immunol 2017;PMID: 28295020. Article Request Form

Frisoli TM, Nowak R, Evans KL, Harrison M, Alani M, Varghese S, Rahman M, Noll S, Flannery KR, Michaels A, Tabaku M, Jacobsen G, and McCord J. Henry Ford HEART score randomized trial: Rapid discharge of patients evaluated for possible myocardial infarction Circ Cardiovasc Qual Outcomes 2017; 10(10)PMID: 28954802. Full Text

Gold DR, Adamkiewicz G, Arshad SH, Celedon JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, and Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management J Allergy Clin Immunol 2017;PMID: 28502823. Full Text

Gould MK, Sakoda LC, Ritzwoller DP, Simoff MJ, Neslund-Dudas CM, Kushi LH, Carter-Harris L, Feigelson HS, Minowada G, and Doria-Rose VP. Monitoring lung cancer screening utilization and outcomes in four cancer research network sites Ann Am Thorac Soc 2017;PMID: 28683215. Full Text

Haley L, Burmeister C, Buekers T, and Elshaikh MA. Is older age a real adverse prognostic factor in women with early-stage endometrial carcinoma? A matched analysis Int J Gynecol Cancer 2017;PMID: 28060139. Full Text

Haque R, UlcickasYood M, Xu X, Cassidy-Bushrow AE, Tsai HT, Keating NL, Van Den Eeden SK, and Potosky AL. Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study Br J Cancer 2017; 117(8):1233-1240. PMID: 29017178. Full Text

Havstad S, Sitarik AR, Johnson CC, Zoratti EM, Ownby DR, Levin AM, and Wegienka G. Allergic sensitization in American children of Middle Eastern ethnicity at age 2 Ann Allergy Asthma Immunol 2017;PMID: 28941706. Full Text

Iwata AJ, Williams AM, Taylor AR, and Chang SS. Socioeconomic disparities and comorbidities, not race, affect salivary gland malignancy survival outcomes Laryngoscope 2017;PMID: 28498500. Full Text

Jiang AJ, Eide MJ, Alexander GL, Altschuler A, Asgari MM, Geller AC, Fletcher SW, Halpern AC, and Weinstock MA. Providers' experiences with a melanoma web-based course: A discussion on barriers and intentions J Cancer Educ 2017; 32(2):272-279. PMID: 26391994. Article Request Form

Jindal T, Kachroo N, Sammon J, Dalela D, Sood A, Vetterlein MW, Karabon P, Jeong W, Menon M, Trinh QD, and Abdollah F. Racial differences in prostate-specific antigen-based prostate cancer screening: State-by-state and region-by-region analyses Urol Oncol 2017;PMID: 28256311. Full text

Johnson CC, Jankowski M, Rolnick S, Yood MU, and Alford SH. Influence of NSAID use among colorectal cancer survivors on cancer outcomes Am J Clin Oncol 2017; 40(4):370-374. PMID: 25503426. Full Text

Kim W, Oravec D, Divine GW, Flynn MJ, and Yeni YN. Effect of view, scan orientation and analysis volume on digital tomosynthesis (dts) based textural analysis of bone Ann Biomed Eng 2017;PMID: 28083858. Full Text

Lamerato L, Price K, Szymialis R, Eaddy M, Ogbonnaya A, Shih HC, and Ahmad H. Comparative evaluation of treatment patterns and healthcare utilization of newly-diagnosed rheumatoid arthritis patients by anti-cyclic citrullinated peptide antibody status J Med Econ 2017:1-10. PMID: 29027497. Article Request Form

Lanfear DE, Gibbs JJ, Li J, She R, Petucci C, Culver JA, Tang WHW, Pinto YM, Williams LK, Sabbah HN, and Gardell SJ. Targeted metabolomic profiling of plasma and survival in heart failure patients JACC Heart Fail 2017; 5(11):823-832. PMID: 29096792. Full Text

Lareau CA, DeWeese CF, Adrianto I, Lessard CJ, Gaffney PM, Iannuzzi MC, Rybicki BA, Levin AM, and Montgomery CG. Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry Genes Immun 2017;PMID: 28275240. Article Request Form

Lee JK, Mahan M, Hanna RK, and Elshaikh MA. Survival outcomes and patterns of failure in women with stage IIIC2 endometrial carcinoma Eur J Obstet Gynecol Reprod Biol 2017; 216:192-197. PMID: 28800504. Full Text

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LeWitt PA, Li J, Lu M, Guo L, and Auinger P. Metabolomic biomarkers as strong correlates of Parkinson disease progression Neurology 2017;PMID: 28179471. Full text

Liu YB, Gao X, Deeb D, Pindolia K, and Gautam SC. Role of telomerase in anticancer activity of pristimerin in prostate cancer cells J Exp Ther Oncol 2017; 11(1):41-49. PMID: 28976122. Article Request Form

Loppenberg B, Sood A, Dalela D, Karabon P, Sammon JD, Vetterlein MW, Noldus J, Peabody JO, Trinh QD, Menon M, and Abdollah F. Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: A national cancer data base analysis 2004 to 2013 Clin Genitourin Cancer 2017;PMID: 28558991. Full Text

Lu M, Chacra W, Rabin D, Rupp LB, Trudeau S, Li J, and Gordon SC. Validity of an automated algorithm using diagnosis and procedure codes to identify decompensated cirrhosis using electronic health records Clin Epidemiol 2017; 9:369-376. PMID: 28744162. Full Text

Malosh RE, Martin ET, Callear AP, Petrie JG, Lauring AS, Lamerato L, Fry AM, Ferdinands J, Flannery B, and Monto AS. Respiratory syncytial virus hospitalization in middle-aged and older adults J Clin Virol 2017; 96:37- 43. PMID: 28942341. Full Text

McCord J, Cabrera R, Lindahl B, Giannitsis E, Evans K, Nowak R, Frisoli T, Body R, Christ M, deFilippi CR, Christenson RH, Jacobsen G, Alquezar A, Panteghini M, Melki D, Plebani M, Verschuren F, French J, Bendig G, Weiser S, and Mueller C. Prognostic utility of a modified HEART score in chest pain patients in the emergency department Circ Cardiovasc Qual Outcomes 2017; 10(2)PMID: 28167641. Full text

Modh A, Burmeister C, Munkarah AR, and Elshaikh MA. External pelvic and vaginal irradiation vs. vaginal irradiation alone as postoperative therapy in women with early stage uterine serous carcinoma: Results of a National Cancer Database analysis Brachytherapy 2017;PMID: 28511891. Full Text

Moller DR, Rybicki BA, Hamzeh NY, Montgomery CG, Chen ES, Drake W, and Fontenot A. Genetic, immunological and environmental basis of sarcoidosis Ann Am Thorac Soc 2017;PMID: 29073364. Full Text

Morris DC, Cheung WL, Loi R, Zhang T, Lu M, Zhang ZG, and Chopp M. Thymosin beta4 for the treatment of acute stroke in aged rats Neurosci Lett 2017; 659:7-13. PMID: 28864242. Full Text

Munblit D, Peroni DG, Boix-Amoros A, Hsu PS, Land BV, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, and Warner JO. Human milk and allergic diseases: An unsolved puzzle Nutrients 2017; 9(8)PMID: 28817095. Full Text

Nagaraja TN, Elmghirbi R, Brown SL, Schultz LR, Lee IY, Keenan KA, Panda S, Cabral G, Mikkelsen T, and Ewing JR. Reproducibility and relative stability in magnetic resonance imaging indices of tumor vascular physiology over a period of 24h in a rat 9L gliosarcoma model Magn Reson Imaging 2017; 44:131-139. PMID: 28887206. Full Text

Nakagawa P, Masjoan-Juncos JX, Basha H, Janic B, Worou ME, Liao TD, Romero CA, Peterson EL, and Carretero OA. Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus Physiol Rep 2017; 5(2)PMID: 28126732. Full Text

Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D, Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, and North KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African ancestry anthropometry genetics consortium PLoS Genet 2017; 13(4):e1006719. PMID: 28430825. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006719

93 Nowak R, Muller C, Giannitsis E, Christ M, Ordonez-Llanos J, DeFilippi C, McCord J, Body R, Panteghini M, Jernberg T, Plebani M, Verschuren F, French JK, Christenson R, Jacobsen G, Dinkel C, and Lindahl B. High sensitivity cardiac troponin t in patients not having an acute coronary syndrome: Results from the trapid-ami study Biomarkers 2017:1-26. PMID: 28532247. Article Request Form

Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, Thomas C, Franceschi AM, Griffith B, Flanders A, Golfinos JG, Chi AS, and Jain R. T2-flair mismatch, an imaging biomarker for idh and 1p/19q status in lower grade gliomas: A tcga/tcia project Clin Cancer Res 2017;PMID: 28751449. Full Text

Patsias I, Swanson B, Hudson M, Parikh S, Nour K, Jacobsen G, and McCord J. The (dis) utility of a change in troponin i for diagnosis of non-st-segment elevation myocardial infarction in an observation unit Crit Pathw Cardiol 2017; 16(3):105-108. PMID: 28742647. Full Text

Peterson PN, Greenlee RT, Go AS, Magid DJ, Cassidy-Bushrow A, Garcia-Montilla R, Glenn KA, Gurwitz JH, Hammill SC, Hayes J, Kadish A, Reynolds K, Sharma P, Smith DH, Varosy PD, Vidaillet H, Zeng CX, Normand ST, and Masoudi FA. Comparison of inappropriate shocks and other health outcomes between single- and dual-chamber implantable cardioverter-defibrillators for primary prevention of sudden cardiac death: Results from the cardiovascular research network longitudinal study of implantable cardioverter-defibrillators J Am Heart Assoc 2017; 6(11)PMID: 29122811. Full Text

Pillai V, Roth T, Roehrs T, Moss K, Peterson EL, and Drake CL. Effectiveness of benzodiazepine receptor agonists in the treatment of insomnia: An examination of response and remission rates Sleep 2017; 40(2)PMID: 28364510. Full Text

Roseland ME, Schwartz K, Ruterbusch JJ, Lamerato L, Krajenta R, Booza J, and Simon MS. Influence of clinical, societal, and treatment variables on racial differences in ER-/PR- breast cancer survival Breast Cancer Res Treat 2017;PMID: 28547656. Full Text

Rundle A, Wang Y, Sadasivan S, Chitale DA, Gupta NS, Tang D, and Rybicki BA. Larger men have larger prostates: Detection bias in epidemiologic studies of obesity and prostate cancer risk Prostate 2017;PMID: 28349547.

Salafia CM, Shah RG, Misra DP, Straughen JK, Roberts DJ, Troxler L, Morgan SP, Eucker B, and Thorp JM. Chorionic vascular "fit" in the human placenta: Relationship to fetoplacental outcomes Placenta 2017; 59:13-18. PMID: 29108632. Full Text

Sherenian MG, Cho SH, Levin A, Min JY, Oh SS, Hu D, Galanter J, Sen S, Huntsman S, Eng C, Rodriguez-Santana JR, Serebrisky D, Avila PC, Kalhan R, Smith LJ, Borrell LN, Seibold MA, Keoki Williams L, Burchard EG, and Kumar R. PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: the GALA II Cohort Clin Exp Allergy 2017;PMID: 28543872. Full Text Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, Mulekar SV, Lim HW, and Hamzavi IH. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas J Am Acad Dermatol 2017;PMID: 28502377. Full Text

Sitarik AR, Bobbitt KR, Havstad SL, Fujimura KE, Levin AM, Zoratti EM, Kim H, Woodcroft KJ, Wegienka G, Ownby DR, Joseph CL, Lynch SV, and Johnson CC. Breast milk tgfbeta is associated with neonatal gut microbial composition J Pediatr Gastroenterol Nutr 2017;PMID: 28362692. Full Text

Sitarik AR, Bobbitt KR, Havstad SL, Fujimura KE, Levin AM, Zoratti EM, Kim H, Woodcroft KJ, Wegienka G, Ownby DR, Joseph CLM, Lynch SV, and Johnson CC. Breast milk transforming growth factor beta is associated with neonatal gut microbial composition J Pediatr Gastroenterol Nutr 2017; 65(3):e60-e67. PMID: 28827481. Full Text

Smith MM, Peterson E, and Yaremchuk KL. The role of tonsillectomy in adults with tonsillar hypertrophy and obstructive sleep apnea Otolaryngol Head Neck Surg 2017:194599817698671. PMID: 28349770. Full Text

Snyder J, Schultz L, and Walbert T. The role of tumor board conferences in neuro-oncology: a nationwide provider survey J Neurooncol 2017;PMID: 28421461. Full Text

Straughen JK, Misra DP, Ernst LM, Charles AK, VanHorn S, Ghosh S, Buhimschi I, Buhimschi C, Divine G, and Salafia CM. Methods to decrease variability in histological scoring in placentas from a cohort of preterm infants BMJ Open 2017; 7(3):e013877. PMID: 28363925. http://bmjopen.bmj.com/content/7/3/e013877.long

94 Straughen JK, Misra DP, Helmkamp L, and Misra VK. Preterm delivery as a unique pathophysiologic state characterized by maternal soluble fms-like tyrosine kinase 1 and uterine artery resistance during pregnancy Reprod Sci 2017:1933719117698574. PMID: 28335685. Full Text

Straughen JK, Bazydlo M, Havstad S, Shafie-Khorassani F, and Misra DP. Maternal body weight trajectories across the life course and risk of preterm delivery J Dev Orig Health Dis 2017:1-8. PMID: 28877776. Article Request Form

Straughen JK, Misra DP, Divine G, Shah R, Perez G, VanHorn S, Onbreyt V, Dygulska B, Schmitt R, Lederman S, Narula P, and Salafia CM. The association between placental histopathology and autism spectrum disorder Placenta 2017; 57:183-188. PMID: 28864010. Full Text

Suleyman G, Mahan M, and Zervos MJ. Comparison of daptomycin and linezolid in the treatment of vancomycin-resistant enterococcus faecium in the absence of endocarditis Infect Dis Clin Pract 2017; 25(3):151- 154. PMID: Not assigned. Full Text

Taneja C, Netsch D, Rolstad BS, Inglese G, Lamerato L, and Oster G. Clinical and economic burden of peristomal skin complications in patients with recent ostomies J Wound Ostomy Continence Nurs 2017;PMID: 28574928. Full Text

Tsafrir Z, Aoun J, Papalekas E, Taylor A, Schiff L, Theoharis E, and Eisenstein D. Risk factors for trachelectomy following supracervical hysterectomy Acta Obstet Gynecol Scand 2017; 96(4):421-425. PMID: 28107774. Full Text

Vetterlein MW, Loppenberg B, Karabon P, Dalela D, Jindal T, Sood A, Chun FK, Trinh QD, Menon M, and Abdollah F. Impact of travel distance to the treatment facility on overall mortality in US patients with prostate cancer Cancer 2017;PMID: 28472547. Full Text

Wang H, Romero CA, Masjoan Juncos JX, Monu SR, Peterson EL, and Carretero OA. Effect of salt intake on afferent arteriolar dilatation: Role of connecting tubule glomerular feedback (CTGF) Am J Physiol Renal Physiol 2017:ajprenal.00320.02017. PMID: 28835421. Full Text

Wilson SP, Vohra T, Knych M, Goldberg J, Price C, Calo S, Mahan M, and Miller J. Gonorrhea and chlamydia in the emergency department: Continued need for more focused treatment for men, women and pregnant women Am J Emerg Med 2017;PMID: 28073612. Full Text

Wilson SP, Vohra T, Goldberg J, Price C, Calo S, Mahan M, and Miller J. Reliable rapid assay for gonorrhea and chlamydia in the emergency department J Emerg Med 2017;PMID: 29074030. Full Text

Xing J, Spradling PR, Moorman AC, Holmberg SD, Teshale EH, Rupp LB, Gordon SC, Lu M, Boscarino JA, Schmidt MA, Trinacty CM, and Xu F. A point system to forecast hepatocellular carcinoma risk before and after treatment among persons with chronic hepatitis c Dig Dis Sci 2017; 62(11):3221-3234. PMID: 28965221. Full Text

Yechieli RL, Robbins JR, Mahan M, Siddiqui F, and Ajlouni M. Stereotactic body radiotherapy for elderly patients with medically inoperable pancreatic cancer Am J Clin Oncol 2017; 40(1):22-26. PMID: 24879474. Full text

Yeo J, Crawford EL, Zhang X, Khuder S, Chen T, Levin A, Blomquist TM, and Willey JC. A lung cancer risk classifier comprising genome maintenance genes measured in normal bronchial epithelial cells BMC Cancer 2017; 17(1):301. PMID: 28464886. Full Text

Zhang J, Gang Zhang Z, Lu M, Wang X, Shang X, Elias SB, and Chopp M. Mir-146a promotes remyelination in a cuprizone model of demyelinating injury Neuroscience 2017;PMID: 28237816. Full text

Zhang L, Chopp M, Lu M, Zhang T, Li C, Winter S, Brandstaetter H, Doppler E, Meier D, Pabla P, and Zhang ZG. Demonstration of therapeutic window of Cerebrolysin in embolic stroke: A prospective, randomized, blinded, and placebo-controlled study Int J Stroke 2017:1747493017702665. PMID: 28382851. Article Request Form

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Abdulfatah E, Sakr S, Thomas S, Al-Wahab Z, Mutch DG, Dowdy S, Bandyopadhyay S, Munkarah A, Elshaikh M, Morris R, and Ali-Fehmi R. Clear cell carcinoma of the endometrium: Evaluation of prognostic parameters in a multi- institutional cohort of 165 cases Int J Gynecol Cancer 2017; 27(8):1714-1721. PMID: 28945214. Full Text

Bagher-Ebadian H, Siddiqui F, Liu C, Movsas B, and Chetty IJ. On the impact of smoothing and noise on robustness of ct and cbct radiomics features for patients with head and neck cancers Med Phys 2017;PMID: 28261818. Article Request Form

Boyce-Fappiano D, Elibe E, Schultz L, Ryu S, Siddiqui MS, Chetty I, Lee I, Rock J, Movsas B, and Siddiqui F. Analysis of the factors contributing to vertebral compression fractures after spine stereotactic radiosurgery Int J Radiat Oncol Biol Phys 2017; 97(2):236-245. PMID: 28068232. Full Text

Boyce-Fappiano D, Elibe E, Zhao B, Siddiqui MS, Lee I, Rock J, Ryu S, and Siddiqui F. Reirradiation of the spine with stereotactic radiosurgery: Efficacy and toxicity Pract Radiat Oncol 2017;PMID: 28673511. Request Article

Brandner ED, Chetty IJ, Giaddui TG, Xiao Y, and Huq MS. Motion management strategies and technical issues associated with stereotactic body radiotherapy of thoracic and upper abdominal tumors: A review from nrg oncology Med Phys 2017;PMID: 28317123. Article Request Form

Chetty IJ, and Fontenot J. Adaptive radiation therapy: Off-line, on-line, and in-line? Int J Radiat Oncol Biol Phys 2017; 99(3):689-691. PMID: 29280464. Full Text

Citrin DE, Prasanna PGS, Walker AJ, Freeman ML, Ekea I, Barcellos-Hoff MH, Arankalayil MJ, Cohen EP, Wilkins RC, Ahmed MM, Anscher MS, Movsas B, Buchsbaum JC, Mendonca MS, Wynn TA, and Coleman CN. Radiation- induced fibrosis: Mechanisms and opportunities to mitigate. Report of an nci workshop, september 19, 2016 Radiat Res 2017;PMID: 28489488. Full Text

Dehkordi AN, Kamali-Asl A, Ewing JR, Wen N, Chetty IJ, and Bagher-Ebadian H. An adaptive model for rapid and direct estimation of extravascular extracellular space in dynamic contrast enhanced MRI studies NMR Biomed 2017;PMID: 28195664. Full text

Dehkordi ANV, Kamali-Asl A, Wen N, Mikkelsen T, Chetty IJ, and Bagher-Ebadian H. DCE-MRI prediction of survival time for patients with glioblastoma multiforme: using an adaptive neuro-fuzzy-based model and nested model selection technique NMR Biomed 2017;PMID: 28543885. Full Text

Elshaikh MA, Vance S, Kamal M, Burmeister C, Hanna RK, Rasool N, and Siddiqui F. Influence of comorbidity on the risk of death: A single institution study of 1132 women with early-stage uterine cancer Am J Clin Oncol 2017; 40(2):183-188. PMID: 25222075. Full Text

Gardner SJ, Lu S, Liu C, Wen N, and Chetty IJ. Tuning of AcurosXB source size setting for small intracranial targets J Appl Clin Med Phys 2017; 18(3):170-181. PMID: 28470819. Full Text

Glide-Hurst CK, Gibbons JP, Jr., and Orton CG. The AAPM should significantly revise its current governance structure Med Phys 2017;PMID: 28681380. Request Article

Haley L, Burmeister C, Buekers T, and Elshaikh MA. Is older age a real adverse prognostic factor in women with early-stage endometrial carcinoma? A matched analysis Int J Gynecol Cancer 2017;PMID: 28060139. Full Text

Holliday EB, Bonner JA, Formenti SC, Hahn SM, Kalnicki S, Liu FF, Movsas B, Fuller CD, and Thomas CR, Jr. Emotional intelligence and burnout in academic radiation oncology chairs J Healthc Manag 2017; 62(5):302- 313. PMID: 28885530. Full Text

Jain M, Gamage NH, Alsulami M, Shankar A, Achyut BR, Angara K, Rashid MH, Iskander A, Borin TF, Wenbo Z, Ara R, Ali MM, Lebedyeva I, Chwang WB, Guo A, Bagher-Ebadian H, and Arbab AS. Intravenous formulation of het0016 decreased human glioblastoma growth and implicated survival benefit in rat xenograft models Sci Rep 2017; 7:41809. PMID: 28139732. Full Text

Jhawar S, Hathout L, Elshaikh MA, Beriwal S, Small W, Jr., and Mahmoud O. Adjuvant chemoradiation therapy for cervical cancer and effect of timing and duration on treatment outcome Int J Radiat Oncol Biol Phys 2017; 98(5):1132-1141. PMID: 28721897. Full Text

96 Jones WE, 3rd, Suh WW, Abdel-Wahab M, Abrams RA, Azad N, Das P, Dragovic J, Goodman KA, Jabbour SK, Konski AA, Koong AC, Kumar R, Lee P, Pawlik TM, Small W, Jr., and Herman JM. ACR appropriateness criteria(r) resectable pancreatic cancer Am J Clin Oncol 2017;PMID: 28230650. Full text

Kearney V, Huang Y, Mao W, Yuan B, and Tang L. Canny edge-based deformable image registration Phys Med Biol 2017; 62(3):966-985. PMID: 28081014. Article Request Form

Kumarasiri A, Liu C, Kamal M, Fraser C, Brown S, Chetty IJ, Kim J, and Siddiqui F. Changes in pharyngeal constrictor volumes during head and neck radiation therapy: Implications for dose delivery J Cancer Res Ther 2017; 13(2):218-223. PMID: 28643737. Full Text

Lee JK, Mahan M, Hanna RK, and Elshaikh MA. Survival outcomes and patterns of failure in women with stage IIIC2 endometrial carcinoma Eur J Obstet Gynecol Reprod Biol 2017; 216:192-197. PMID: 28800504. Full Text

Liu Q, Zhang X, Yin C, Chen X, Zhang Z, Brown S, Xie H, Zhou L, and Mi QS. HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function Oncotarget 2017;PMID: 28177888. Full text

Mahdi Z, Abdulfatah E, Pardeshi V, Hassan O, Schultz D, Morris R, Cote ML, Elshaikh MA, Bandyopadhyay S, and Ali-Fehmi R. The impact of androgen receptor expression on endometrial carcinoma recurrence and survival Int J Gynecol Pathol 2017;PMID: 28277313. Full Text

Mao W, Rozario T, Lu W, Gu X, Yan Y, Jia X, Sumer B, and Schwartz DL. Online dosimetric evaluation of larynx SBRT: A pilot study to assess the necessity of adaptive replanning J Appl Clin Med Phys 2017; 18(1):157-163. PMID: 28291932. Full Text

McLaughlin PW, Liss AL, Nguyen PL, Assimos DG, D'Amico AV, Gottschalk AR, Gustafson GS, Keole SR, Liauw SL, Lloyd S, Movsas B, Prestidge BR, Showalter TN, Taira AV, Vapiwala N, and Davis BJ. ACR appropriateness criteria(r) locally advanced, high-risk prostate cancer Am J Clin Oncol 2017; 40(1):1-10. PMID: 28059930. Full Text

Modh A, Burmeister C, Munkarah AR, and Elshaikh MA. External pelvic and vaginal irradiation vs. vaginal irradiation alone as postoperative therapy in women with early stage uterine serous carcinoma: Results of a National Cancer Database analysis Brachytherapy 2017;PMID: 28511891. Full Text

Movsas B. Radiation therapy in elderly persons: An old issue with new approaches Int J Radiat Oncol Biol Phys 2017; 98(4):715-717. PMID: 28602405. Full Text

Muir B, Culberson W, Davis S, Kim GY, Huang Y, Lee SW, Lowenstein J, Sarfehnia A, Siebers J, and Tolani N. Insight gained from responses to surveys on reference dosimetry practices J Appl Clin Med Phys 2017;PMID: 28397396. Full Text

Nagaraja TN, Elmghirbi R, Brown SL, Schultz LR, Lee IY, Keenan KA, Panda S, Cabral G, Mikkelsen T, and Ewing JR. Reproducibility and relative stability in magnetic resonance imaging indices of tumor vascular physiology over a period of 24h in a rat 9L gliosarcoma model Magn Reson Imaging 2017; 44:131-139. PMID: 28887206. Full Text

Nakagawa P, Masjoan-Juncos JX, Basha H, Janic B, Worou ME, Liao TD, Romero CA, Peterson EL, and Carretero OA. Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus Physiol Rep 2017; 5(2)PMID: 28126732. Full Text

Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. A parametric model of the brain vascular system for estimation of the arterial input function (AIF) at the tissue level NMR Biomed 2017;PMID: 28211963. Full text

Nejad-Davarani SP, Bagher-Ebadian H, Ewing JR, Noll DC, Mikkelsen T, Chopp M, and Jiang Q. An extended vascular model for less biased estimation of permeability parameters in DCE-T1 images NMR Biomed 2017;PMID: 28211961. Full text

Pierce LJ, Feng M, Griffith KA, Jagsi R, Boike T, Dryden D, Gustafson GS, Benedetti L, Matuszak MM, Nurushev TS, Haywood J, Radawski JD, Speers C, Walker EM, Hayman JA, and Moran JM. Recent time trends and predictors of heart dose from breast radiation therapy in a large quality consortium of radiation oncology practices Int J Radiat Oncol Biol Phys 2017;PMID: 28927756. Full Text

97 Price RG, Knight RA, Hwang KP, Bayram E, Nejad-Davarani SP, and Glide-Hurst CK. Optimization of a novel large field of view distortion phantom for MR-only treatment planning J Appl Clin Med Phys 2017;PMID: 28497476. Full Text

Puiu T, Porto DA, Siddiqui F, and Lim HW. Tumor-stage mycosis fungoides regressing with milia and pustules after total skin electron beam therapy J Eur Acad Dermatol Venereol 2017;PMID: 28557155. Full Text

Qin Y, Gardner SJ, Kim J, Huang Y, Wen N, Doemer A, and Chetty IJ. Evaluation of plastic scintillator detector for small field stereotactic patient-specific quality assurance Med Phys 2017;PMID: 28714067. Request Article

Ritter TA, Matuszak M, Chetty IJ, Mayo CS, Wu J, Iyengar P, Weldon M, Robinson C, Xiao Y, and Timmerman RD. Application of critical volume-dose constraints for stereotactic body radiation therapy in nrg radiation therapy trials Int J Radiat Oncol Biol Phys 2017; 98(1):34-36. PMID: 28587050. Full Text

Siddiqui F, and Movsas B. Management of radiation toxicity in head and neck cancers Semin Radiat Oncol 2017; 27(4):340-349. PMID: 28865517. Full Text

Sidiropoulos C, Bowyer SM, Zillgitt A, LeWitt PA, Bagher-Ebadian H, Davoodi-Bojd E, Schwalb JM, Rammo R, Air E, and Soltanian-Zadeh H. Multimodal imaging in a patient with hemidystonia responsive to gpi deep brain stimulation Case Rep Neurol Med 2017; 2017:9653520. PMID: 28744382. Full Text

Snyder KC, Liu M, Zhao B, Huang Y, Ning W, Chetty IJ, Siddiqui MS. Investigating the dosimetric effects of grid size ondose calculation accuracy using volumetric modulated arc therapy in spine stereotactic radiosurgery J radiosurg SBRT 2017;4(4):303-313 PMID: 29296454

Stinchcombe TE, Zhang Y, Vokes EE, Schiller JH, Bradley JD, Kelly K, Curran WJ, Jr., Schild SE, Movsas B, Clamon G, Govindan R, Blumenschein GR, Socinski MA, Ready NE, Akerley WL, Cohen HJ, Pang HH, and Wang X. Pooled analysis of individual patient data on concurrent chemoradiotherapy for stage iii non-small-cell lung cancer in elderly patients compared with younger patients who participated in us national cancer institute cooperative group studies J Clin Oncol 2017:Jco2016714758. PMID: 28493811. Full Text

Videtic GMM, Donington J, Giuliani M, Heinzerling J, Karas TZ, Kelsey CR, Lally BE, Latzka K, Lo SS, Moghanaki D, Movsas B, Rimner A, Roach M, Rodrigues G, Shirvani SM, Simone CB, 2nd, Timmerman R, and Daly ME. Stereotactic body radiation therapy for early-stage non-small cell lung cancer: Executive Summary of an ASTRO Evidence-Based Guideline Pract Radiat Oncol 2017;PMID: 28596092. Article Request Form

Williams AM, Lindholm J, Siddiqui F, Ghanem TA, and Chang SS. Clinical assessment of cognitive function in patients with head and neck cancer: Prevalence and correlates Otolaryngol Head Neck Surg 2017:194599817709235. PMID: 28585482. Full Text

Williams AM, Lindholm J, Cook D, Siddiqui F, Ghanem TA, and Chang SS. Association between cognitive function and quality of life in patients with head and neck cancer JAMA Otolaryngol Head Neck Surg 2017;PMID: 29121151. Full Text

Yechieli RL, Robbins JR, Mahan M, Siddiqui F, and Ajlouni M. Stereotactic body radiotherapy for elderly patients with medically inoperable pancreatic cancer Am J Clin Oncol 2017; 40(1):22-26. PMID: 24879474. Full text Zaorsky NG, Showalter TN, Ezzell GA, Nguyen PL, Assimos DG, D'Amico AV, Gottschalk AR, Gustafson GS, Keole SR, Liauw SL, Lloyd S, McLaughlin PW, Movsas B, Prestidge BR, Taira AV, Vapiwala N, and Davis BJ. Acr appropriateness criteria(r) external beam radiation therapy treatment planning for clinically localized prostate cancer, part i of ii Adv Radiat Oncol 2017; 2(1):62-84. PMID: 28740916. Full Text

Zaorsky NG, Showalter TN, Ezzell GA, Nguyen PL, Assimos DG, D'Amico AV, Gottschalk AR, Gustafson GS, Keole SR, Liauw SL, Lloyd S, McLaughlin PW, Movsas B, Prestidge BR, Taira AV, Vapiwala N, and Davis BJ. ACR Appropriateness Criteria for external beam radiation therapy treatment planning for clinically localized prostate cancer, part II of II Adv Radiat Oncol 2017; 2(3):437-454. PMID: 29114613. Full Text

Zhao B, Wen N, Chetty IJ, Huang Y, Brown SL, Snyder K, Siddiqui F, Movsas B, and Siddiqui MS. A prediction model of radiation-induced necrosis for intracranial radiosurgery based on target volume Med Phys 2017;PMID: 28543402. Full Text

Zhong H, Siddiqui S, Movsas B, and Chetty I. Evaluation of adaptive treatment planning for patients with non-small cell lung cancer Phys Med Biol 2017;PMID: 28072395. Article Request Form

98 Zhong H, and Chetty IJ. Adaptive radiotherapy for NSCLC patients: utilizing the principle of energy conservation to evaluate dose mapping operations Phys Med Biol 2017; 62(11):4333-4345. PMID: 28475493. Article Request Form

Zhong H, and Chetty IJ. In Reply to Hugo et al Int J Radiat Oncol Biol Phys 2017; 99(5):1310. PMID: 29165294. Full Text

RESEARCH ADMINISTRATION

Image Analysis Program

Afzali M, Fatemizadeh E, and Soltanian-Zadeh H. Sparse registration of diffusion weighted images Comput Methods Programs Biomed 2017; 151:33-43. PMID: 28947004. Full Text

Izadi H, Baniassadi M, Hasanabadi A, Mehrgini B, Memarian H, Soltanian-Zadeh H, and Abrinia K. Application of full set of two point correlation functions from a pair of 2D cut sections for 3D porous media reconstruction J Pet Sci Eng 2017; 149:789-800. PMID: Not assigned. Article request form

Mohammadi-Nejad AR, Hossein-Zadeh GA, and Soltanian-Zadeh H. Structured and sparse canonical correlation analysis as a brain-wide multi-modal data fusion approach IEEE Trans Med Imaging 2017; 36(7):1438-1448. PMID: 28320654. Request Article

Sidiropoulos C, Bowyer SM, Zillgitt A, LeWitt PA, Bagher-Ebadian H, Davoodi-Bojd E, Schwalb JM, Rammo R, Air E, and Soltanian-Zadeh H. Multimodal imaging in a patient with hemidystonia responsive to gpi deep brain stimulation Case Rep Neurol Med 2017; 2017:9653520. PMID: 28744382. Full Text

Genetics Research

Ferreira P, Chan A, and Wolf B. Irreversibility of symptoms with biotin therapy in an adult with profound biotinidase deficiency JIMD Rep 2017;PMID: 28220409. Article request form

Maheras KJ, Pindolia K, Wolf B, and Gow A. Developmental window of sensorineural deafness in biotinidase- deficient mice J Inherit Metab Dis 2017;PMID: 28516283. Full Text

Strovel ET, Cowan TM, Scott AI, and Wolf B. Laboratory diagnosis of biotinidase deficiency, 2017 update: a technical standard and guideline of the American College of Medical Genetics and Genomics Genet Med 2017;PMID: 28682309. Request Article

SURGERY

Amankwaa-Frempong E, Yeboah FA, Nguah SB, and Newman LA. Breast cancer genetic testing among african patients with breast cancer: Deoxyribonucleic acid extraction from tumor tissue and international multidisciplinary partnerships JAMA Surg 2017; 152(8):800-801. PMID: 28514482. Full Text

Bauman ZM, Ruggero JM, Squindo S, McEachin C, Jaskot M, Ngo W, Barnes S, and Lopez PP. Repeat Head CT? Not Necessary for Patients with a Negative Initial Head CT on Anticoagulation or Antiplatelet Therapy Suffering Low-Altitude Falls Am Surg 2017; 83(5):429-435. PMID: 28541850. Full Text

Camaj A, Zahuranec DB, Paone G, Benedetti BR, Behr WD, Zimmerman MA, Zhang M, Kramer RS, Penn J, Theurer PF, Paugh TA, Engoren M, DeLucia A, 3rd, Prager RL, and Likosky DS. Organizational contributors to the variation in red blood cell transfusion practices in cardiac surgery: Survey results from the state of Michigan Anesth Analg 2017;PMID: 28719425. Full Text

Carruthers NJ, Stemmer PM, Chen B, Valeriote F, Gao X, Guatam SC, and Shaw J. Phosphoproteome and transcription factor activity profiling identify actions of the anti-inflammatory agent UTL-5g in LPS stimulated RAW 264.7 cells including disrupting actin remodeling and STAT-3 activation Eur J Pharmacol 2017;PMID: 28576409. Article Request Form

Catanescu I, Long G, Bove P, Khoury M, Brown O, Rimar S, Rizk Y, Uzieblo M, and Hans S. Rupture of abdominal aortic aneurysm in patients with and without antecedent endovascular repair Ann Vasc Surg 2017; 39:99-104. PMID: 27522971. Full Text

99 Church JT, Coughlin MA, Antunez AG, Smith EA, and Bruch SW. Creating diagnostic criteria for perforated appendicitis using cross-sectional imaging Pediatr Surg Int 2017;PMID: 28674919. Full Text

Colburn JL, Mohanty S, and Burton JR. Surgical guidelines for perioperative management of older adults: What geriatricians need to know J Am Geriatr Soc 2017;PMID: 28323335. Full Text

Davis FM, Sutzko DC, Grey SF, Mansour MA, Jain KM, Nypaver TJ, Gaborek G, and Henke PK. Predictors of surgical site infection after open lower extremity revascularization J Vasc Surg 2017; 65(6):1769-1778.e1763. PMID: 28527931. Full Text

DeCaporale-Ryan L, Sakran JV, Grant SB, Alseidi A, Rosenberg T, Goldberg RF, Sanfey H, Dubose J, Stawicki S, Ricca R, Derrick ET, Bernstein CA, Jardine DA, Stefanou AJ, Aziz B, He E, Dissanaike S, Fortuna CGR, Jr., Oviedo RJ, Shapiro J, Galowitz P, and Moalem J. The undiagnosed pandemic: Burnout and depression within the surgical community Curr Probl Surg 2017; 54(9):453-502. PMID: 29073980. Full Text

Deeb D, Gao X, Liu, YB, Zhang Y, Shaw J, Valeriote FA, and Gautam SC. Inhibition of hTERT in pancreatic cancer cells by pristimerin involves suppression of epigenetic regulators of gene transcription Oncology Reports 2017; 37(3):1914-1920. PMID: Not yet assigned. Article request form

DeSantis CE, Ma J, Goding Sauer A, Newman LA, and Jemal A. Breast cancer statistics, 2017, racial disparity in mortality by state CA Cancer J Clin 2017; 67(6):439-448. PMID: 28972651. Full Text

Frisoli TM, Wang DD, Eng M, O'Neill WW, Paone G, and Greenbaum AB. Mitral annuloplasty ring fracture and annular injury during transcatheter mitral valve-in-ring intervention JACC Cardiovasc Interv 2017; 10(19):e181-e184. PMID: 28982567. Full Text

Gaye MM, Ding T, Shion H, Hussein A, Hu Y, Zhou S, Hammoud ZT, Lavine BK, Mechref Y, Gebler JC, and Clemmer DE. Delineation of disease phenotypes associated with esophageal adenocarcinoma by MALDI-IMS- MS analysis of serum N-linked glycans Analyst 2017;PMID: 28367546. Article Request Form

Go P, Watson J, Lu Z, Carlin A, and Hammoud Z. Robotic resection of a mediastinal parathyroid cyst Gen Thorac Cardiovasc Surg 2017; 65(1):52-55. PMID: 26353995. Full Text

Goodwin M, Nemeh HW, Borgi J, Paone G, and Morgan JA. Resolution of mitral regurgitation with left ventricular assist device support Ann Thorac Surg 2017;PMID: 28527962. Full Text

Grossman PM, Ali SS, Aronow HD, Boros M, Nypaver TJ, Schreiber TL, Park YJ, Henke PK, and Gurm HS. Contrast-induced nephropathy in patients undergoing endovascular peripheral vascular intervention: Incidence, risk factors, and outcomes as observed in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium J Interv Cardiol 2017;PMID: 28370487. Full Text

Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, and Craig DW. A method to reduce ancestry related germline false positives in tumor only somatic variant calling BMC Med Genomics 2017; 10(1):61. PMID: 29052513. Full Text

Jesse MT, Abouljoud M, Eshelman A, De Reyck C, and Lerut J. Professional interpersonal dynamics and burnout in european transplant surgeons Clin Transplant 2017;PMID: 28185307. Full text

Karamanos E, Dream S, Falvo A, Schmoekel N, and Siddiqui A. Use of epidural analgesia as an adjunct in elective abdominal wall reconstruction: A review of 4983 cases Perm J 2017; 21PMID: 29035177. Full Text

Ketterer MW, Chawa M, and Paone G. Prospective correlates of early (30 day) readmissions on a cardiothoracic surgery service Psychol Health Med 2017:1-8. PMID: 28161983. Article request form

Lehrberg A, and Kharbutli B. Isolated unilateral adrenal gland hemorrhage following motor vehicle collision: a case report and review of the literature J Med Case Rep 2017; 11(1):358. PMID: 29277157. Full Text

Liu YB, Gao X, Deeb D, Pindolia K, and Gautam SC. Role of telomerase in anticancer activity of pristimerin in prostate cancer cells J Exp Ther Oncol 2017; 11(1):41-49. PMID: 28976122. Article Request Form

Macki M, Basheer A, Lee I, Kather R, Rubinfeld I, and Abdulhak MM. Surgical site infection after transoral versus posterior approach for atlantoaxial fusion: a matched-cohort study J Neurosurg Spine 2017:1-7. PMID: 29076762. Full Text

100 Marrocco A, and Krouse HJ. Obstacles to preventive care for individuals with disability: Implications for nurse practitioners J Am Assoc Nurse Pract 2017;PMID: 28266148. Full Text

Miller SM, Nalamati S, and Cordova AC. Human papillomavirus manifestation after kidney-pancreas transplantation Am J Transplant 2017; 17(7):1949-1951. PMID: 28658535. Full Text

Newman LA, and Kaljee LM. Health disparities and triple-negative breast cancer in african american women: A review JAMA Surg 2017;PMID: 28355428. Full Text

Newman LA. Do patterns of breast cancer surgical care reflect national voting records? JAMA Surg 2017;PMID: 28355435. Full Text

Newman LA. Breast cancer disparities: Socioeconomic factors versus biology Ann Surg Oncol 2017;PMID: 28766222. Full Text

Park KU, and Nathanson D. Translating the 2-dimensional mammogram into a 3-dimensional breast: Identifying factors that influence the movement of pre-operatively placed wire J Surg Oncol 2017;PMID: 28475815. Full Text

Rountree KM, and Lopez PP. Emphysematous gastritis, a spectrum of disease: A four-case report Am Surg 2017; 83(8):285-287. PMID: 28822362. Full Text

Rountree KM, and Blase JJ. Isolated orbital roof blow-in fracture Trauma Case Rep 2017; 12:16-18. PMID: Not assigned. Article Request Form

Safwan M, Collins KM, Abouljoud MS, and Salgia R. Outcome of liver transplantation in patients with prior bariatric surgery Liver Transpl 2017;PMID: 28752920. Full Text

Shimunov S, and Baidoun F. Denture molding causing small bowel obstruction: Case study Surgery 2017;PMID: 28111045. Full Text

Skoog DJ, Pohlmann JR, Demos DS, Scipione CN, Iyengar A, Schewe RE, Suhaib AB, Koch KL, and Cook KE. Fourteen day in vivo testing of a compliant thoracic artificial lung Asaio j 2017; 63(5):644-649. PMID: 28719441. Full Text

Smith TA, Knepper J, Woo K, Rathbun J, and Johnson B. A look ahead into advanced alternative payment models in vascular surgery J Vasc Surg Venous Lymphat Disord 2017; 5(6):905. PMID: 29037365. Full Text

Steinbeisser M, McCracken J, and Kharbutli B. Laparoscopic sleeve gastrectomy: Preoperative weight loss and other factors as predictors of postoperative success Obes Surg 2017;PMID: 28050788. Full Text

Takahashi K, Prashar R, Putchakayala KG, Kane WJ, Denny JE, Kim DY, and Malinzak LE. Allograft loss from acute Page kidney secondary to trauma after kidney transplantation World J Transplant 2017; 7(1):88-93. PMID: 28280700. Full Text

Takahashi K, Go P, Stone CH, Safwan M, Putchakayala KG, Kane WJ, Malinzak LE, Kim DY, and Denny JE. Mycophenolate mofetil and pulmonary fibrosis after kidney transplantation: A case report Am J Case Rep 2017; 18:399-404. PMID: 28408734. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398249/

Takahashi K, Nagai S, Puchakayala KG, Safwan M, Gosho M, Li AY, Kane WJ, Singh PL, Rizzari MD, Collins KM, Yoshida A, Abouljoud MS, and Schnickel GT. Prediction of biliary anastomotic stricture after deceased donor liver transplantation: The impact of platelet counts Transpl Int 2017;PMID: 28605573. Full Text

Takahashi K, Patel AK, Nagai S, Safwan M, Putchakayala KG, Kane WJ, Malinzak LE, Denny JE, Yoshida A, and Kim DY. Perioperative ketorolac use: A potential risk factor for renal dysfunction after live-donor nephrectomy Ann Transplant 2017; 22:563-569. PMID: 28924138. Full Text

Takahashi K, Putchakayala KG, Safwan M, and Kim DY. Extrahepatic metastasis of hepatocellular carcinoma to the paravertebral muscle: A case report World J Hepatol 2017; 9(22):973-978. PMID: 28839518. Full Text

Thomas AS, Kidwell KM, Oppong JK, Adjei EK, Osei-Bonsu E, Boahene A, Jiggae E, Gyan K, and Merajver SD. Breast cancer in ghana: Demonstrating the need for population-based cancer registries in low- and middle- income countries J Glob Oncol 2017; 3(6):765-772. PMID: 29244986. Full Text

101 Varban OA, Sheetz KH, Cassidy RB, Stricklen A, Carlin AM, Dimick JB, and Finks JF. Evaluating the effect of operative technique on leaks after laparoscopic sleeve gastrectomy: a case-control study Surg Obes Relat Dis 2017; 13(4):560-567. PMID: 28089439. Full Text

Varban OA, Cassidy RB, Bonham A, Carlin AM, Ghaferi A, and Finks JF. Factors associated with achieving a body mass index of less than 30 after bariatric surgery JAMA Surg 2017;PMID: 28746723. Full Text

Vasileff WK, Nekhline M, Kolowich PA, Talpos GB, Eyler WR, and van Holsbeeck M. Inguinal hernia in athletes: Role of dynamic ultrasound Sports Health 2017:1941738117717009. PMID: 28732177. Full Text

Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, and Kearon C. Pharmacomechanical catheter-directed thrombolysis for deep-vein thrombosis N Engl J Med 2017; 377(23):2240- 2252. PMID: 29211671. Full Text

Vuyyuru S, and Kharbutli B. Epidermoid cyst of the spleen, a case report Int J Surg Case Rep 2017; 35:57- 59. PMID: 28441587. Full Text

Plastic Surgery

Boucree T, McLaughlin D, Akrawe S, Darian V, and Siddiqui A. Posterior iliac crest bone graft: How much is enough? J Craniofac Surg 2017; 28(8):2162-2164. PMID: 28968327. Full Text

Fuzesi S, Cano SJ, Klassen AF, Atisha D, and Pusic AL. Validation of the electronic version of the BREAST-Q in the army of women study Breast 2017; 33:44-49. PMID: 28279888. Full Text

Karamanos E, Dream S, Falvo A, Schmoekel N, and Siddiqui A. Use of epidural analgesia as an adjunct in elective abdominal wall reconstruction: A review of 4983 cases Perm J 2017; 21PMID: 29035177. Full Text

Sever AJ, Patel C, Albeer Y, and Darian VB. The technique and benefits of angiographic embolization of inferior epigastric arteries prior to pedicled tram flap breast reconstruction: Results from a single center Cardiovasc Intervent Radiol 2017;PMID: 28536869 Full Text

Yaremchuk K, Darian V, and Williams AM. Seasonality of auricular amputations in rabbits Laryngoscope 2017; 127(4):773-775. PMID: 28322456. Full Text

UROLOGY

Abaza R, Eun DD, Gallucci M, Gill IS, Menon M, Mottrie A, and Shabsigh A. Robotic surgery for renal cell carcinoma with vena caval tumor thrombus European Urology Focus 2017;PMID: Not assigned. Full Text

Abdollah F, Dalela D, Sood A, Sammon J, Cho R, Nocera L, Diaz M, Jeong W, Peabody JO, Fossati N, Gandaglia G, Briganti A, Montorsi F, and Menon M. Functional outcomes of clinically high-risk prostate cancer patients treated with robot-assisted radical prostatectomy: a multi-institutional analysis Prostate Cancer Prostatic Dis 2017;PMID: 28462944. Article Request Form

Abdollah F, Jindal T, and Menon M. Surgical training in the robotic surgery era: The importance of structured programs Eur Urol Focus 2017; 3(1):117-118. PMID: 28720355. Full Text

Alanee SR, Shah S, Zabor EC, Vijai J, Ostrovnaya I, Garcia-Grossman IR, Pendse DV, Littman J, Regazzi AM, Offit K, and Bajorin DF. Evaluating the association of multiple single nucleotide polymorphisms with response to gemcitabine and platinum combination chemotherapy in urothelial carcinoma of the bladder Int J Clin Pharmacol Ther 2017; 55(3):203-209. PMID: 28177276. Article Request Form

Alanee S, Delfino K, Wilber A, Robinson K, Brard L, and Semaan A. Single nucleotide variant in Nucleoporin 107 may be predictive of sensitivity to chemotherapy in patients with ovarian cancer Pharmacogenet Genomics 2017; 27(7):264-269. PMID: 28562428. Full Text Arora S. Reply to: Biochemical failure after radical prostatectomy in intermediate-risk group men increases with the number of risk factors Indian J Urol 2017; 33(2):176-177. PMID: 28469312. Full Text

102 Arora S, Gautam G, Khera R, and Ahlawat RK. Preoperative predictors of extraprostatic extension of prostate cancer (pt3a) in a contemporary indian cohort Indian J Surg Oncol 2017; 8(3):331-336. PMID: Not assigned. Full Text

Arora S, Campbell L, Tourojman M, Pucheril D, Jones LR, and Rogers C. Robotic buccal mucosal graft ureteroplasty for complex ureteral stricture Urology 2017; 110:257-258. PMID: 29153902. Full Text

Baas W, Gershburg S, Dynda D, Delfino K, Robinson K, Nie D, Yearley JH, and Alanee S. Immune characterization of the programmed death receptor pathway in high risk prostate cancer Clin Genitourin Cancer 2017;PMID: 28461179. Full Text

Chakravarthi BV, Goswami MT, Pathi SS, Dodson M, Chandrashekar DS, Agarwal S, Nepal S, Hodigere Balasubramanya SA, Siddiqui J, Lonigro RJ, Chinnaiyan AM, Kunju LP, Palanisamy N, and Varambally S. Expression and role of paics, a de novo purine biosynthetic gene in prostate cancer Prostate 2017; 77(1):10- 21. PMID: 27550065. Full Text

Cole AP, Jiang W, Lipsitz SR, Learn PA, Sun M, Choueiri TK, Nguyen PL, Kibel AS, Menon M, Sammon JD, Koehlmoos T, Haider A, and Trinh QD. The use of prostate-specific antigen screening in purchased versus direct care settings: Data from the tricare military database J Urol 2017;PMID: 28716650. Full Text

Colicchia M, Sharma V, Abdollah F, Briganti A, and Jeffrey Karnes R. Therapeutic Value of Standard Versus Extended Pelvic Lymph Node Dissection During Radical Prostatectomy for High-Risk Prostate Cancer Curr Urol Rep 2017; 18(7):51. PMID: 28589397. Full Text

Dalela D, Santiago-Jimenez M, Yousefi K, Karnes RJ, Ross AE, Den RB, Freedland SJ, Schaeffer EM, Dicker AP, Menon M, Briganti A, Davicioni E, and Abdollah F. Genomic classifier augments the role of pathological features in identifying optimal candidates for adjuvant radiation therapy in patients with prostate cancer: Development and internal validation of a multivariable prognostic model J Clin Oncol 2017:Jco2016699918. PMID: 28350520. Full Text

Dalela D, Jeong W, Prasad MA, Sood A, Abdollah F, Diaz M, Karabon P, Sammon J, Jamil M, Baize B, Simone A, and Menon M. A pragmatic randomized controlled trial examining the impact of the retzius-sparing approach on early urinary continence recovery after robot-assisted radical prostatectomy Eur Urol 2017;PMID: 28483330. Full Text

Dalela D, and Abdollah F. Editorial Comment J Urol 2017;PMID: 28780289. Full Text

Favazza L, Chitale DA, Barod R, Rogers CG, Kalyana-Sundaram S, Palanisamy N, Gupta NS, and Williamson SR. Renal cell tumors with clear cell histology and intact VHL and chromosome 3p: a histological review of tumors from the Cancer Genome Atlas database Mod Pathol 2017;PMID: 28731045. Full Text

Harms KL, Chubb H, Zhao L, Fullen DR, Bichakjian CK, Johnson TM, Carskadon S, Palanisamy N, and Harms PW. Increased expression of ezh2 in merkel cell carcinoma is associated with disease progression and poorer prognosis Hum Pathol 2017;PMID: 28739498. Full Text

Hawken SR, Auffenberg GB, Miller DC, Lane BR, Cher ML, Abdollah F, Cho H, and Ghani KR. Calculating life expectancy to inform prostate cancer screening and treatment decisions BJU Int 2017;PMID: 28199761. Full text

Holland BC, Shetty Z, and Alanee S. The effect of targeted therapy for genitourinary malignancies on sexual function and fertility Curr Urol Rep 2017; 18(8):65. PMID: 28712040. Full Text

Hussein AA, Ahmed YE, Kozlowski JD, May P, Nyquist J, Sexton S, Curtin L, Peabody JO, Abol-Enein H, and Guru KA. Robot-assisted approach to w configuration urinary diversion:A step-by-step technique BJU Int 2017;PMID: 28220593. Full text

Hussein AA, May PR, Ahmed YE, Saar M, Wijburg CJ, Richstone L, Wagner A, Wilson T, Yuh B, Redorta JP, Dasgupta P, Kawa O, Khan MS, Menon M, Peabody JO, Hosseini A, Gaboardi F, Pini G, Schanne F, Mottrie A, Rha KH, Hemal A, Stockle M, Kelly J, Tan WS, Maatman TJ, Poulakis V, Kaouk J, Canda AE, Balbay MD, Wiklund P, and Guru KA. Development of a patient and institutional-based model for estimation of operative times for robot- assisted radical cystectomy: Results from the international robotic cystectomy consortium BJU Int 2017;PMID: 28620985.

Jindal T, Kachroo N, Sammon J, Dalela D, Sood A, Vetterlein MW, Karabon P, Jeong W, Menon M, Trinh QD, and Abdollah F. Racial differences in prostate-specific antigen-based prostate cancer screening: State-by-state and region-by-region analyses Urol Oncol 2017;PMID: 28256311. Full text

103 Leyh-Bannurah SR, Budaus L, Pompe R, Zaffuto E, Briganti A, Abdollah F, Montorsi F, Schiffmann J, Menon M, Shariat SF, Fisch M, Chun F, Huland H, Graefen M, and Karakiewicz PI. North american population-based validation of the national comprehensive cancer network practice guideline recommendation of pelvic lymphadenectomy in contemporary prostate cancer Prostate 2017; 77(5):542-548. PMID: 28093788. Full Text

Leyh-Bannurah SR, Gazdovich S, Budaus L, Zaffuto E, Briganti A, Abdollah F, Montorsi F, Schiffmann J, Menon M, Shariat SF, Fisch M, Chun F, Steuber T, Huland H, Graefen M, and Karakiewicz PI. Local therapy improves survival in metastatic prostate cancer Eur Urol 2017;PMID: 28385454. Full Text

Loppenberg B, Sood A, Dalela D, Karabon P, Sammon JD, Vetterlein MW, Noldus J, Peabody JO, Trinh QD, Menon M, and Abdollah F. Variation in locoregional prostate cancer care and treatment trends at commission on cancer designated facilities: A national cancer data base analysis 2004 to 2013 Clin Genitourin Cancer 2017;PMID: 28558991. Full Text

Lucas SM, Kim TK, Ghani KR, Miller DC, Linsell S, Starr J, Peabody JO, Hurley P, Montie J, and Cher ML. Establishment of a Web-based System for Collection of Patient-reported Outcomes After Radical Prostatectomy in a Statewide Quality Improvement Collaborative Urology 2017; 107:96-102. PMID: 28652160. Full Text

Meyer CP, Krasnova A, Sammon JD, Lipsitz SR, Weissman JS, Sun M, and Trinh QD. Accountable care organizations and the use of cancer screening Prev Med 2017; 101:15-17. PMID: 28528171. Full Text

Meyer CP, Rios-Diaz AJ, Dalela D, Ravi P, Sood A, Hanske J, Chun FKH, Kibel AS, Lipsitz SR, Sun M, and Trinh QD. The association of hypoalbuminemia with early perioperative outcomes - A comprehensive assessment across 16 major procedures Am J Surg 2017; 214(5):871-883. PMID: 29106849. Full Text

Murlidhar V, Reddy RM, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott PW, Lynch WR, Orringer MB, Kumar-Sinha C, Palanisamy N, Beer DG, Wicha MS, Ramnath N, Azizi E, and Nagrath S. Poor prognosis indicated by venous circulating tumor cell clusters in early stage lung cancers Cancer Res 2017;PMID: 28716896. Full Text

Nocera L, Karabon P, and Abdollah F. 10-Year Outcomes in Localized Prostate Cancer N Engl J Med 2017; 376(2):178-179. PMID: 28079331. Full Text

Palma-Zamora ID, and Atiemo HO. Understanding the economic impact of neurogenic lower urinary tract dysfunction Urol Clin North Am 2017; 44(3):333-343. PMID: 28716315. Full Text

Palma-Zamora I, Sood A, and Dabaja AA. 30-day adverse event rates following penile prosthesis surgery: An american college of surgeons national surgical quality improvement program based evaluation Transl Androl Urol 2017; 6(Suppl 5):S767-s773. PMID: 29238657. Full Text

Pucheril D, Chun B, Dalela D, Abdollah F, Laker SA, and Rogers CG. Robot-assisted laparoscopic repair of extraperitoneal ureteral inguinal hernia with mesh placement J Endourol Case Rep 2017; 3(1):97-100. PMID: 28894843. Full Text

Rahbar H, and Rogers C. Renal tumour biopsy: let's talk about it BJU Int 2017; 119(4):507-508. PMID: 28319355. Full Text

Seisen T, Briganti A, Blanchard P, and Abdollah F. Salvage radiation therapy for biochemical recurrence after radical prostatectomy: Is earlier always better? J Clin Oncol 2017:Jco2016706879. PMID: 28135149. Full Text

Seisen T, Trinh QD, and Abdollah F. Could lead-time bias explain the apparent benefits of early salvage radiotherapy? Nat Rev Urol 2017;PMID: 28169994. Article request form

Seisen T, Sun M, Lipsitz SR, Abdollah F, Leow JJ, Menon M, Preston MA, Harshman LC, Kibel AS, Nguyen PL, Bellmunt J, Choueiri TK, and Trinh QD. Comparative effectiveness of trimodal therapy versus radical cystectomy for localized muscle-invasive urothelial carcinoma of the bladder Eur Urol 2017;PMID: 28412065. Full Text

Smith SC, Gooding WE, Elkins M, Patel RM, Harms PW, McDaniel AS, Palanisamy N, Uram-Tuculescu C, Balzer BB, Lucas DR, Seethala RR, and McHugh JB. Solitary fibrous tumors of the head and neck: A multi-institutional clinicopathologic study Am J Surg Pathol 2017;PMID: 28877055. Full Text

104 Sood A, Kachroo N, Abdollah F, Sammon JD, Loppenberg B, Jindal T, Sun M, Trinh QD, Menon M, and Peabody JO. An evaluation of the timing of surgical complications following radical cystectomy: Data from the american college of surgeons national surgical quality improvement program (ACS-NSQIP) Urology 2017;PMID: 28216450. Full text

Sood A, and Abdollah F. Re: Diagnostic accuracy of multi-parametric magnetic resonance imaging and transrectal ultrasound biopsy in prostate cancer (promis): A paired validating confirmatory study Eur Urol 2017;PMID: 28412064. Full Text

Sood A, Menon M, Hirst A, McCulloch P, and Ghani KR. Hey, I just did a better operation! Toward an ideal innovation model Ann Surg 2017; 266(1):e9. PMID: 28591016. Full Text

Sood A, Meyer CP, Abdollah F, Sammon JD, Sun M, Lipsitz SR, Hollis M, Weissman JS, Menon M, and Trinh QD. Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality Br J Surg 2017;PMID: 28632890. Full Text

Sood A, Phelps J, Palma-Zamora I, Jindal T, Abdollah F, Vuljaj A, Sammon JD, Trinh QD, Menon M, and Atiemo H. Emergency department utilization in patients with neurogenic bladder: Contemporary burden and national trends in prevalence, inpatient admission and associated charges 2006-2011 Urology 2017;PMID: 28755964. Full Text

Sood A, Abdollah F, Sammon JD, Menon M, and Rogers CG. Classification of partial nephrectomy as an outpatient surgery under cms part b reimbursement program—does the evidence justify the recommendation? Urol Pract 2017; 4(6):444-447. PMID: Not assigned. Full Text

Spratt DE, Yousefi K, Deheshi S, Ross AE, Den RB, Schaeffer EM, Trock BJ, Zhang J, Glass AG, Dicker AP, Abdollah F, Zhao SG, Lam LL, du Plessis M, Choeurng V, Haddad Z, Buerki C, Davicioni E, Weinmann S, Freedland SJ, Klein EA, Karnes RJ, and Feng FY. Individual patient-level meta-analysis of the performance of the decipher genomic classifier in high-risk men after prostatectomy to predict development of metastatic disease J Clin Oncol 2017:Jco2016702811. PMID: 28358655. Full Text

Territo A, Mottrie A, Abaza R, Rogers C, Menon M, Bhandari M, Ahlawat R, and Breda A. Robotic kidney transplantation: current status and future perspectives Minerva Urol Nefrol 2017; 69(1):5-13. PMID: 28009142. Article Request Form

Thamilselvan V, Menon M, Stein GS, Valeriote F, and Thamilselvan S. Combination of carmustine and selenite Inhibits EGFR mediated growth signaling in androgen-independent prostate cancer cells J Cell Biochem 2017;PMID: 28430389. Full Text

Vetterlein MW, Loppenberg B, Karabon P, Dalela D, Jindal T, Sood A, Chun FK, Trinh QD, Menon M, and Abdollah F. Impact of travel distance to the treatment facility on overall mortality in US patients with prostate cancer Cancer 2017;PMID: 28472547. Full Text

Vetterlein MW, Wankowicz SAM, Seisen T, Lander R, Loppenberg B, Chun FK, Menon M, Sun M, Barletta JA, Choueiri TK, Bellmunt J, Trinh QD, and Preston MA. Neoadjuvant chemotherapy prior to radical cystectomy for muscle-invasive bladder cancer with variant histology Cancer 2017;PMID: 28743155. Full Text

Vetterlein MW, Seisen T, Speed J, Friedlander DF, Meyer CP, Kibel AS, Menon M, Fisch M, Chun FKH, Sun M, Eswara JR, and Trinh QD. 30-day adverse events following cystectomy for bladder cancer versus benign bladder conditions Urology Practice 2017; 4(5):388-394. PMID: Not assigned. Full Text

Wang L, Harms PW, Palanisamy N, Carskadon S, Cao X, Siddiqui J, Patel RM, Zelenka-Wang S, Durham AB, Fullen DR, Harms K, Su F, Shukla S, Mehra R, and Chinnaiyan AM. Age and gender associations of virus positivity in Merkel cell carcinoma characterized using a novel RNA in situ hybridization assay Clin Cancer Res 2017;PMID: 28606924. Full Text

Wei X, Choudhury Y, Lim WK, Anema J, Kahnoski RJ, Lane B, Ludlow J, Takahashi M, Kanayama HO, Belldegrun A, Kim HL, Rogers C, Nicol D, Teh BT, and Tan MH. Recognizing the continuous nature of expression heterogeneity and clinical outcomes in clear cell renal cell carcinoma Sci Rep 2017; 7(1):7342. PMID: 28779136. Full Text

Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Priya Kunju L, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, and Gupta NS. Diagnostic criteria for oncocytic renal neoplasms: A survey of urologic pathologists Hum Pathol 2017;PMID: 28315424. Full Text

105

HENRY FORD HEALTH SYSTEM ABSTRACTS JAN-DEC 2017

ANESTHESIOLOGY

Al-Darzi W, El-Atrache M, Georgie F, Sadiq O, Singla S, Fernandez C, Pompa R, Galusca D, Yoshida A, and Jafri SM. Risk factors and outcomes of intracardiac thrombosis during orthotopic liver transplantation Am J Transplant 2017; 17:582. PMID: Not assigned. Abstract

Asif A, Malik M, Lundberg KA, Tarabishy A, and Hanna JS. Effectiveness of mexiletine for treatment of neuropathic pain Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Bogan J, Saraswat A, Alsaden MR, and Guruswamy J. Neuraxial analgesia in a patient with factor XII deficiency Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Chauhan G, Loomba V, Upadhyay A, and Sibai N. A case report on use of Mexiletine as panacea for opioid induced hyperalgesia Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Chauhan G, Patri M, and Loomba V. Cervical myelopathy after neck manipulation in a patient with cervical spondylosis with radiculopathy. Cause and effect or natural progression? Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Chauhan G, Patri M, Mordis C, Sandeepram B, and Hehar P. Information Needs Assessment regarding postoperative pain: Gender based analysis of adult population Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Davis H, Galusca D, Nanamori M, and Morita Y. Portopulmonary hypertension and atrial fibrillation in liver transplantation Anesthesia and Analgesia 2017; 124:439-439. PMID: Not assigned. Abstract

Chauhan G, and Garzon-Serrano J. Evaluation of low cost high fidelity USB powered arterial line simulation device for ultrasound guided vascular puncture and cannulation Anesth Analg 2017; 124(5):26-27. PMID: Not assigned. Abstract

Jain T, Wang DD, Eng M, Isley M, Paone G, Greenbaum A, and O'Neill W. Transcatheter mitral valve-in-ring implantation after failure of surgical mitral ring annuloplasty J Am Coll Cardiol 2017; 69(11):1262-1262. PMID: Not assigned. Abstract

Khanduja S, Larimore K, Loomba V, Sibai N, and Upadhyay A. A retrospective review of mri results for low backache: Are we over investigating? Pain Med 2017; 18(3):602-603. PMID: Not assigned. Abstract

Lencho T, and Morita Y. Modified tricuspid annular plane systolic excursion and its association with postoperative course in heart transpant patients Anesth Analg 2017; 124:111-112. PMID: Not assigned. Abstract

Malik MF, and Alsaden MR. Retrospective analysis of post-operative adductor canal block with epidural anesthesia for total knee replacement Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Mbuvah F, and Garzon-Serrano J. Ultrasound guided serratus anterior plane block for thoracic analgesia in a patient with multiple rib fractures Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Mbuvah F, Haddad R, Sibai N, and Kataria P. Mexiletine therapy for buerger's disease Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Meselhy E, Loomba V, and Upadhyay A. A stellate ganglion block for a patient with complex regional pain syndrome Type i following a transient ischemic attack Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Navas J, Lopez-Plaza I, Nakai K, Isley M, Ghatol D, Brightman D, Parrott S, and Galusca D. Road to zero blood waste: Improving intraoperative blood utilization through a multidisciplinary collaborative Anesth Analg 2017; 125(3):24-25. PMID: Not assigned. Abstract

Sherdiwala B, Subramanian H, and Alsaden MRA. Labor epidural analgesia in patients with neurofibromatosis type 1 Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

106 Subramanian H, Sherdiwala B, and Walton L. Are Lumbar-Peritoneal shunts a contra-indication to Epidural anesthesia in the age of the Ultrasound? Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

Vu Z, Alsaden M, and Fidkowski C. Ultrasound-guided modified out of plane infraclavicular approach Reg Anesth Pain Med 2017; 42(6)PMID: Not assigned. Abstract

BEHAVIORAL HEALTH SERVICES/PSYCHIATRY

Imami L, Stanton S, Zilioli S, Tobin ET, and Luca F. Self-disclosure and perceived responsiveness in youth with asthma: Links to gene expression and psychological well-being Psychosom Med 2017; 79(4):A147-A148. PMID: Not assigned. Abstract

Jesse M, Rebhan N, Yoshida A, Moonka D, Eshelman A, Abouljoud M, and Rizzari M. Substance abuse in acute liver failure: Time to talk about opiates Am J Transplant 2017; 17:240. PMID: Not assigned. Abstract

Toledo T, and Akinyemi E. Caregiver burnout: Application of dialectal behavioral therapy Am J Geriatr Psychiatry 2017; 25(3):S88-S89. PMID: Not assigned. Abstract

Psychology/Neuropsychology

ElShatanoufy S, Wang Y, Matthews A, Jamil ML, Yousif M, Gutta S, Gill H, and Luck A. Effect of morbid obesity on mid-urethral sling effecacy for the management of stress urinary incontinence Female Pelvic Med Reconstr Surg 2017; 23(5):S41. PMID: Not assigned. Abstract

Ryan M. Leveraging electronic distress screening: Building equity and high-value psychosocial care Psycho- Oncology 2017; 26:21-22. PMID: Not assigned. Abstract

Sousa D, Matthews A, Yousif M, Jesse M, Elshatanoufy S, and Richardson D. Divergent perceptions of gender interactions in a medical teaching environment Obstet Gynecol 2017; 130:46S-46S. PMID: Not assigned. Abstract

Williams A, Ghanem T, Siddiqui F, and Chang S. Clinical assessment of cognitive function in head and neck cancer Psycho-Oncology 2017; 26:74-74. PMID: Not assigned. Abstract

Williams A, Goldberg W, Varkas T, and Ryan M. Distress screening for program building: Similarities and differences among patient populations Psycho-Oncology 2017; 26:100. PMID: Not assigned. Abstract

CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH

Daya M, Rafaels NM, Chavan S, Boorgula M, Johnston HR, Wilson J, Williams LK, Rotimi C, Ober C, Meyers D, Bleeker E, Ortega VE, Knight-Madden J, Hansel NN, Watson H, Faruque MU, Dunston GM, Caraballo L, Araujo MI, Burchard EG, Taub M, Ruczinski I, Beaty T, Qin ZS, Mathias R, and Barnes KC. Genome-wide association study of asthma in individuals of mixed african ancestry reveals a novel association on chromosome 2q14 Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Hofmeister MG, Xing J, Moorman AC, Rupp LB, Gordon SC, Boscarino JA, Schmidt MA, Daida YH, Lu M, Teshale EH, Holmberg SD, Spradling PR, and Investigators CH. Health outcomes among surveyed patients infected with hepatitis C in the Chronic Hepatitis Cohort Study (CHeCS) Hepatology 2017; 66:559A-559A. PMID: Not assigned. Abstract

Li J, Gordon SC, Rupp LB, Zhang TL, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida Y, and Lu M. Does Hepatitis C eradication lead to improved glucose metabolism, renal and cardiovascular outcomes in diabetic patients? Hepatology 2017; 66:525A-525A. PMID: Not assigned. Abstract

Li J, Zhang TL, Gordon SC, Rupp LB, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida YH, Lu M, and For The Chronic Hepatitis Cohort S. Impact of sustained virological response on incidence of type 2 diabetes in hepatitis c patients Hepatology 2017; 66:531A-531A. PMID: Not assigned. Abstract

107 Lu M, Zhou YR, Haller I, Romanelli R, VanWormer JJ, Rodriguez CV, Anderson H, Boscarino JA, Schmidt MA, Daida Y, Sahota AK, Vincent J, Bowlus CL, Lindor KD, Zhang T, Trudeau S, Li J, Rupp LB, Gordon SC, and Fibrotic Liver Dis FC. Epidemiologic trends and treatment survival benefits in a US cohort of patients with primary biliary cholangitis (PBC) Hepatology 2017; 66:157A-157A. PMID: Not assigned. Abstract.

Pawaskar M, Iglay K, Witt EA, Rajpathak S, Engel SS, and Williams LK. The relationship between hypoglycemia severity and work productivity loss and costs among type 2 diabetes patients Value in Health 2017; 20(5):A169- A169. PMID: Not assigned. Abstract

Sherenian MG, Cho SH, Levin AM, Min JY, Sen S, Oh S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Borrell L, Williams LK, Thyne S, Seibold MA, Burchard E, and Kumar R. PAI- 1 gain of function genotype and airway obstruction in asthma J Allergy Clin Immunol 2017; 139(2):AB171. PMID: Not assigned. Abstract

CLINICAL QUALITY AND SAFETY

Behrendt R, Cerasale M, Craft S, and Beg M. Pathway for early sepsis identification and treatment in the skilled nursing facility J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Cerasale M, Mani Marashi S, Coniglio B, Entz A, Watson P, Kaatz S, and Jordan J. Missed and refused chemoprophylaxis: What is the impact on vte? J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Cerasale M, Mani Marashi S, Faraone H, Kaatz S, Ritz J, Watson P, and Jordan J. Padua to improve: Matching vte risk stratificaiton tool to the ehr J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

COMMUNITY HEALTH EQUITY AND WELLNESS

Omar J, Heidemann DL, Blum-Alexandar B, Uju-Eke C, Alam Z, Willens DE, and Wisdom K. Fresh prescription: Improving nutrition education and access to fresh produce in detroit J Gen Intern Med 2017; 32(2):S752. PMID: Not assigned. Abstract

DERMATOLOGY

Agrawal S, and Watson P. Tether-induced tenosynovitis: The importance of an intact skin barrier J Am Acad Dermatol 2017; 76(6):AB247. PMID: Not assigned. Abstract

Ahmed H, Morrow C, Yusuf N, Lim HW, Hamzavi I, Burns E, Shaheen A, Muzaffar A, Abdelgawwad M, Al-Sadek C, Foy T, Kumar R, Ptacek T, Huda S, Isedeh P, and Kohli I. Ultraviolet radiation alters the skin microbiome composition J Invest Dermatol 2017; 137(5):S102-S102. PMID: Not assigned. Abstract

Antonyan A, and McGoey J. Multiple eruptive verrucous dermatofibromas in the setting of lupus erythematosus and epidermal nevus J Ame Acad Dermato 2017; 76(6):AB172. PMID: Not assigned. Abstract

Bagel J, Lebwohl M, Stein-Gold L, Jackson JM, Chen R, Goncalves J, Duffin KC, and Strober B. Efficacy of apremilast on quality of life measures in patients with moderate plaque psoriasis (UNVEIL phase 4 study) J Am Acad Dermatol 2017; 76(6):AB119. PMID: Not assigned. Abstract

Baumann L, Goldberg DJ, Stein-Gold L, Tanghetti EA, Lain E, Kaufman J, and Ahluwalia G. Efficacy and safety of topical oxymetazoline cream 1.0% for the treatment of facial erythema associated with rosacea: Findings from the second of 2 pivotal trials J Am Acad Dermatol 2017; 76(6):AB115. PMID: Not assigned. Abstract

Bhatia BK, and Hamzavi IH. Identifying gaps in the narrowband ultraviolet B phototherapy guidelines for vitiligo Pigment Cell Melanoma Res 2017; 30(5):e131. PMID: Not assigned. Abstract

Brescoll J, Hamel R, and Kohen L. Pseudoverrucous papules and nodules in the setting of a chronically draining abscess J Am Acad Dermatol 2017; 76(6):AB207. PMID: Not assigned. Abstract

Del Rosso JQ, Stein-Gold LF, Kircik L, Tan J, Maari C, Bissonnette R, Zib B, Quiring J, and Webster G. Olumacostat glasaretil (DRM01) for the treatment of acne vulgaris: Primary results from the DRM01-ACN02 phase 2b randomized controlled trial J Am Acad Dermatol 2017; 76(6):AB184. PMID: Not assigned. Abstract

108 Eichenfield LF, and Stein-Gold L. Addressing the immunopathogenesis of atopic dermatitis: Advances in topical and systemic treatment Semin Cutan Med Surg 2017; 36:S45-S48. PMID: Not assigned. Abstract

Eichenfield LF, and Stein-Gold L. Practical strategies for the diagnosis and assessment of atopic dermatitis Semin Cutan Med Surg 2017; 36:S36-S38. PMID: Not assigned. Abstract

Eichenfield L, Call R, Forsha D, Fowler J, Hebert A, Spellman M, Stein-Gold L, VanSyoc M, Tan B, Tallman A, and Tschen E. Long-term safety of crisaborole ointment in children, adolescents, and adults with mild to moderate atopic dermatitis Pediatr Dermatol 2017; 34:S32-S33. PMID: Not assigned. Abstract

Gaulding J, and Kohen L. Neutrophilic dermatosis of the dorsal hands J Am Acad Dermatol 2017; 76(6):AB178. PMID: Not assigned. Abstract

Hertel DP, Jiang AJ, and Lim HW. A woman with hyperkeratotic, verrucous plaques on her back J Am Acad Dermatol 2017; 76(6):AB30. PMID: Not assigned. Abstract

Kannan S, and Ozog D. Challenges of laser assisted drug delivery for the treatment of palmoplantar dermatologic conditions Lasers Surg Med 2017; 49(4):432-432. PMID: Not assigned. Abstract

Kechichian E, Bhatia B, Hamzavi I, Castelneau JP, Meurant JM, Seneschal J, and Ezzedine K. VITI-SUN: A multicentric prospective study to evaluate sun protection behavior in patients with vitiligo Pigm Cell Melanoma Res 2017; 30(5):e58. PMID: Not assigned. Abstract

Khasawneh R, Unnikrishnan A, Mahmoud B, Hamzavi I, and Heydari AR. Desensitization of basal cell carcinoma to the anti-tumoral effect of vitamin D: Role of REDD1 FASEB Journal 2017; 31(1)PMID: Not Assigned. Abstract

Kohli I, Chaowattanapanit S, Mohammad TF, Nicholson CL, Kollias N, Lim HW, and Hamzavi IH. The synergistic effect of minimal amounts of long-wavelength ultraviolet A1 and visible light on pigmentation J Invest Dermatol 2017; 137(5):S138-S138. PMID: Not assigned. Abstract

Lebwohl M, Stein-Gold L, Snel A, and Reich K. A phase 3 randomized, double-blind trial comparing the efficacy and safety of the fixed combination calcipotriene 0.005% (Cal) and betamethasone dipropionate 0.064% (BD) aerosol foam with the aerosol foam vehicle used twice weekly as long-termmaintenance J Am Acad Dermatol 2017; 76(6):AB21. PMID: Not assigned. Abstract

Li D, Wikstrom J, Herter E, Li X, Pivarcsi A, Sonkoly E, Ståhle M, Mi Q, Zhou L, and Xu Landén N. Comparison of microRNAome of human normal and chronic wounds reveals microRNA-17w92 is critical for wound repair J Invest Dermatol 2017; 137(10):S306. PMID: Not assigned. Abstract

Madigan L, and Lim H. Hemorrhagic bullous amyloidosis J Am Acad Dermatol 2017; 76(6):AB152. PMID: Not assigned. Abstract

Martin CE, Yao Y, Mi QS, and Zhou L. MiRNAs are required for embryonic development of Langerhans Cells J Immunol 2017; 198(1) PMID: Not assigned. Abstract

Mehta D, and Ozog D. Use of ablative fractional co2 laser for scars in skin type iv-vi Lasers Surg Med 2017; 49:31- 31. PMID: Not assigned. Abstract

Mehta D, O'Brien R, and Kohen L. How to improve sun protection counseling in a primary care setting J Am Acad Dermatol 2017; 76(6):AB158. PMID: Not assigned. Abstract

Mi X, Yao Y, Liu Q, Kumar A, Gao H, Zhou L, and Mi QS. HDAC3 controls homeostasis of retina-resident microglia derived from embryonic precursors J Immunol 2017; 198(1) PMID: Not assigned. Abstract

Milgraum D, Patel D, and Shwayder T. Peculiar pattern over the deltoid Pediatr Dermatol 2017; 34:S172- S173. PMID: Not assigned. Abstract

Mohammad T, and Hamzavi I. Use of the 532nm q-switched neodymium-doped yttrium aluminium garnet laser for the treatment of recalcitrant re-repigmentation in vitiligo Lasers Surg Med 2017; 49(4):460-460. PMID: Not assigned. Abstract

Nicholson C, Hamzavi I, and Ozog D. The role of the carbon dioxide laser in the treatment of advanced hidradenitis suppurativa and in post-surgical complications Lasers Surg Med 2017; 49:32-32. PMID: Not assigned. Abstract

109 Patel DP, and Jahnke M. Pediatric lichen sclerosus: A retrospective series Pediatr Dermatol 2017; 34:S174. PMID: Not assigned. Abstract

Porto D, and Ozog D. Creating an effective laser procedural video Lasers Surg Med 2017; 49:34-34. PMID: Not assigned. Abstract

Putchakayala K, Skorupski S, Farhan S, Chaffins M, Ilias S, Pahari H, Collins K, Nagai S, and Abouljoud M. Graft-versus-host disease following deceased donor liver transplant Am J Transplant 2017; 17:783-784. PMID: Not assigned. Abstract

Riis PT, Saunte D, Marmol VD, Benhadou F, Guillem P, El-Domyati M, Abdel-Wahab H, Antoniou C, Dessinioti C, Gurer MA, Beksac B, Szepietowski J, Mathusiak L, Emtestam L, Lapins J, Kottb HR, Doss N, Massa AF, Hamzavi I, Nicholson C, Dolenc-Voljc M, Kim KH, Ohn J, Zouboulis C, Karagiannidis I, Durienc P, Mokos ZB, Jemec GBE, and Faster Better Study G. Clinical characteristics of low and high BMI Hidradenitis suppurativa patients Exp Dermatol 2017; 26:14-15. PMID: Not assigned. Abstract

Sheinin R, Maranda E, Rubin B, and Lim HW. Eosinophilic fasciitis associated with pyoderma gangrenosum: Report of a case and discussion J Am Acad Dermatol 2017; 76(6):AB123. PMID: Not assigned. Abstract

Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, Mulekar SV, Lim HW, and Hamzavi IH. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas J Am Acad Dermatol 2017; 77(2):318-327. PMID: Not assigned. Abstract

Smith Z, and Pritchett EN. Skin cancer in skin of color transplant patients J Am Acad Dermatol 2017; 76(6):AB236. PMID: Not assigned. Abstract

Stein-Gold L, and Eichenfield LF. Nonpharmacologic strategies and topical agents for treating atopic dermatitis: An update Semin Cutan Med Surg 2017; 36:S42-S44. PMID: Not assigned. Abstract

Stein-Gold L, and Eichenfield LF. Atopic dermatitis progression: Evaluating intervention strategies Semin Cutan Med Surg 2017; 36:S39-S41. PMID: Not assigned. Abstract

Stein-Gold L, Tan J, Kircik L, and Rueda MJ. Evolution of acne assessments and impact on acne medications: An evolving, imperfect paradigm Pediatr Dermatol 2017; 34:S102. PMID: Not assigned. Abstract

Stein-Gold L, and Werschler WP. Adapalene/benzoyl peroxide 0.3%/2.5%: An effective acne therapy regardless of age or gender J Am Acad Dermatol 2017; 76(6):AB34. PMID: Not assigned. Abstract

Stein-Gold L, Kircik LH, Diana Draelos Z, Werschler P, DuBois J, Lain E, Goldberg DJ, Kaufman J, and Tanghetti EA. Efficacy and safety of topical oxymetazoline cream 1.0% for treatment of facial erythema associated with rosacea: Findings from two phase 3, pivotal trials J Am Acad Dermatol 2017; 76(6):AB115. PMID: Not assigned. Abstract

Strober B, Bagel J, Lebwohl JM, Stein-Gold L, Jackson JM, Chen R, Levi E, and Duffin KC. Efficacy and safety of apremilast in patients with moderate plaque psoriasis (UNVEIL phase 4 study) J Am Acad Dermatol 2017; 76(6):AB111. PMID: Not assigned. Abstract

Wang J, Wu X, Bosselut R, Zhou L, and Mi QS. Aberrant generation and function of natural killer T (NKT) cell in absence of Utx and Jmjd3 J Immunol 2017; 198(1)PMID: Not assigned. Abstract

Weiss J, Stein-Gold L, Rueda MJ, and Tanghetti E. Adapalene 0.3%/benzoyl peroxide 2.5% gel for the treatment of severe inflammatory acne: A randomized, double-blind, parallel-group, controlled study Pediatr Dermatol 2017; 34:S103. PMID: Not assigned. Abstract

Weiss J, Stein-Gold L, Tanghetti E, Dujols C, and Rueda MJ. Efficacy and safety of adapalene 0.3%/benzoyl peroxide 2.5% topical gel inmoderate and severe acne vulgaris Pediatr Dermatol 2017; 34:S31. PMID: Not assigned. Abstract

Wu X, Zhou L, Wang J, Li G, and Mi QS. MiR150 over-expression impairs iNKT cell development, maturation, and function J Immunol 2017; 198(1)PMID: Not assigned. Abstract

Yao Y, Liu Q, Martin CE, Zhou L, and Mi QS. Embryonic fate mapping uncovers the critic role of miRNAs in skin- resident γδ T cell ontogeny J Immunol 2017; 198(1)PMID: Not assigned. Abstract

110 Yao Y, and Mi Q. Embryonic fate mapping uncovers the critic role of miRNAs in skin-resident gamma delta T cell ontogeny J Invest Dermatol 2017; 137(5):S11-S11. PMID: Not Assigned. Abstract

DIAGNOSTIC RADIOLOGY

Ali MM, Jayasundara S, and Ewing JR. Development and testing of nanoformulation of a vascular disrupting agent in rat glioma with MRI monitoring Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Bagher-Ebadian H, Janic B, Liu C, Pantelic M, Hearshen D, Chetty IJ, Elshaikh M, Movsas B, and Wen N. An equilibrium model for characterization and classification of dominant intraprostatic lesions and normal tissues in patients with prostate cancer Med Phys 2017; 44(6):3096. PMID: Not assigned. Abstract

Bagher-Ebadian H, Branislava J, Liu C, Pantelic M, Hearshen D, Chetty I, Elshaikh M, Movsas B, and Wen N. Examination and evaluation of MR radiomics features for characterization of dominant intraprostatic lesions Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Bagher-Ebadian H, Janic B, Liu C, Pantelic M, Hearshen D, Elshaikh MA, Movsas B, Chetty IJ, and Wen N. Detection of dominant intraprostatic lesions in patients with prostate cancer using an artificial neural network and MR multimodal radiomics analysis Int J Radiat Oncol Biol Phys 2017; 99(2):S82-S83. PMID: Not assigned. Abstract

Bakalyar D. SU-F-I-39: In search of infinity: Finding the limiting dose for an infinite ct scan on a cylinder of finite length Med Phys 2016; 43(6):3395. PMID: 28046880. Abstract

Bakalyar D, Feng W, and McKenney S. SU-G-206-06: Analytic dose function for ct scans in infinite cylinders as a function of scan length and cylinder radius Med Phys 2016; 43(6):3640. PMID: 28046900. Abstract

Bakalyar D, and Vanderhoek M. Determining CTDIvol for cone beam ct with partial rotational coverage and wide beams: Symmetry and reciprocity Med Phys 2017; 44(6):2774. PMID: Not assigned. Abstract

Balraj P, Kabbani L, Mathews J, Tinney F, Schwartz S, Kwon D, Braun F, and Wasilenko S. Epithelioid hemangioendothelioma presenting as inferior vena cava obstruction diagnosed using an endovascular thrombectomy device Ann Vasc Surg 2017; 40:3. PMID: Not assigned. Abstract

Baumer TG, Dischler J, Mende V, Zauel R, Van Holsbeeck M, Siegal DS, Moutzouros V, and Bey MJ. Influence of asymptomatic rotator cuff pathology on in-vivo shoulder motion and clinical outcomes J Orthop Res 2017; 35PMID: Not assigned. Abstract

Bevins N. MO-F-204-00: Preparing for the ABR diagnostic and nuclear medical physics exams Med Phys 2016; 43(6):3708. PMID: 28048871. Abstract

Eng M, Dee Wang D, Greenbaum A, Gheewala N, Aka T, Song T, Pantelic M, Keimig T, Hawasli H, Kendall B, Wyman J, Myers E, and O'Neill W. Prospective, randomized comparison of 3-dimensional computed tomography guidance versus tee data for left atrial appendage occlusion (pro3dlaao) J Am Coll Cardiol 2017; 70(18):B216. PMID: Not assigned. Abstract

Flynn M. TU-D-206-00: Body tomosynthesis Med Phys 2016; 43(6):3748. PMID: 28048053. Abstract

Flynn M. TU-FG-206-01: Standards support for color in medical imaging Med Phys 2016; 43(6):3760. PMID: 28047330. Abstract

Flynn M. TU-D-206-02: Body tomosynthesis image features and artifacts Med Phys 2016; 43(6):3748. PMID: 28046727. Abstract

Girotra T, Affan M, Marin H, Schultz L, and Miller D. Factors affecting distal hyperintense vessel sign, a postulated marker for intracranial collateral circulation Neurology 2017; 88(16)PMID: Not assigned. Abstract

Hakim B, Blase JJ, Rheinboldt M, DelProposto Z, and Starcevic V. Upper urinary tract infection: The spectrum of imaging findings from early detection to late complications and atypical variants Emerg Radiol 2017; 24(5):448-449. PMID: Not assigned. Abstract

Hakim B, Rheinboldt M, and DelProposto Z. MDCT imaging of acute gastric pathology: The gamut of imaging findings Emerg Radiol 2017; 24(5):450-451. PMID: Not assigned. Abstract

111 Homa DA, and Potlapally S. Incidental detection of breast cancer on CT scan Emerg Radiol 2017; 24(5):451. PMID: Not assigned. Abstract

Jones A, Dave J, Fisher R, Hulme K, Rill L, Zamora D, Woodward A, Brady S, MacDougall R, Goldman L, Lang S, Peck D, Apgar B, Shepard S, Uzenoff R, and Willis C. TU-FG-209-08: Distribution of the deviation index (di) in digital radiography practices across the United States Med Phys 2016; 43(6):3762. PMID: 28048011. Abstract

Joshi S, and Vanderhoek M. SU-F-I-71: Fetal protection during fluoroscopy: To shield or not to shield? Med Phys 2016; 43(6):3403. PMID: 28047626. Abstract

Katramados AM, Marin H, Kole M, Varelas P, Miller D, Malik S, Hefzy H, Modi S, Schultz L, Marmagkiolis K, Tsitlakidou D, Affan M, and Mitsias P. Analysis of hypoplastic variants of the circle of willis in patients with first-ever lacunar stroke Stroke 2017; 48PMID: Abstract

Kimpe T, Green P, Revie C, and Flynn M. SU-F-I-60: ICC MIWG Displays: Final recommendations for visualization of medical content on color display systems Med Phys 2016; 43(6):3400. PMID: 28047596. Abstract

Leney M, Kim J, Liu C, Sevak P, Glide-Hurst C, Elshaikh M, Pantelic M, Movsas B, Chetty I, and Wen N. MR- only planning for simultaneous integrated boost of MRI-defined dominant intraprostatic lesions Med Phys 2017; 44(6):3043. PMID: Not assigned. Abstract

Lin DS, Rheinboldt M, Griffith B, DelProposto Z, and Heilala A. Reversible callosal splenial lesions in association with febrile illness: Pathophysiology, mri findings and differential diagnostic considerations Emerg Radiol 2017; 24(5):446-447. PMID: Not assigned. Abstract

Massa P, Rheinboldt M, Gonzalez-Sandoval O, DelProposto Z, and Sever A. MDCT and sonographic imaging of post-operative complications of cesarean section: The gamut of acute and chronic findings Emerg Radiol 2017; 24(5):454-455. PMID: Not assigned. Abstract

Modi S, Marin H, Varelas P, and Mitsias P. Role of pial collateral flow in acute ischemic stroke outcomes Neurology 2017; 88(16)PMID: Not assigned. Abstract

Modi S, Shah K, Affan M, Tahir R, Varelas P, and Marin H. Trends of hospitalization cost of aneurysmal subarachnoid hemorrhage in the United States Stroke 2017; 48PMID: Not assigned. Abstract

Nkongchu K. An automated processing tool for the annual performance evaluation of an MRI scanner Med Phys 2017; 44(6):3081. PMID: Not assigned. Abstract

Oravec DJ, Flynn MJ, and Yeni YN. The relationship of whole human vertebral body creep to geometric, microstructural and material properties J Orthop Res 2017; 35PMID: Not assigned. Abstract

Oravec DJ, Kim W, Flynn MJ, and Yeni YN. Whole human vertebral body creep is associated with DTS- derived texture parameters J Orthop Res 2017; 35PMID: Not assigned. Abstract

Santoso A, Song K, Qin Y, Gardner S, Liu C, Cattaneo R, Chetty I, Movsas B, Aljouni M, and Wen N. SU-F-J-38: Dose rates and preliminary evaluation of contouring similarity metrics using 4d cone beam ct Med Phys 2016; 43(6):3414. PMID: 28048111. Abstract

Selim R, Getzen T, and Moonka D. Outcomes of TIPS for ascites as a function of baseline renal function Hepatology 2017; 66:952A-952A. PMID: Not assigned. Abstract

Shah K, Mayer SA, Kole MK, Marin HL, Schultz L, and Miller DJ. Does administration of intravenous contrast impact outcomes upon large vessel occlusion patients undergoing intra-arterial therapy? Interventional Neurology 2017; 6:91. PMID: Not assigned. Abstract

Singh V, McKenney S, Sunde P, Feng W, and Bakalyar D. SU-F-I-05: Dose symmetry for ctdi equivalent measurements with limited angle cbct Med Phys 2016; 43(6):3387. PMID: 28047451. Abstract

Spain JA, Starcevic V, Rheinboldt M, and DelProposto Z. MDCT imaging of pelvic inflammatory disease: The gamut of imaging findings with emphasis on early detection and differential diagnostic considerations Emerg Radiol 2017; 24(5):447. PMID: Not assigned. Abstract

112 Starcevic V, DelProposto Z, Rheinboldt M, and Bhandarkar V. Multimodality emergency imaging of the placenta Emerg Radiol 2017; 24(5):460. PMID: Not assigned. Abstract

Starcevic V, DelProposto Z, Rheinboldt M, Parrish D, and Bhandarkar V. Hemoperitoneum: Beyond trauma Emerg Radiol 2017; 24(5):459-460. PMID: Not assigned. Abstract

Vanderhoek M, and Bevins N. MO-DE-BRA-04: Hands-on fluoroscopy safety training with real-time patient and staff dosimetry Med Phys 2016; 43(6):3698-3699. PMID: 28048751. Abstract

Vanderhoek M. Split-dose Y-90 microsphere therapy: Does a single TC-99m MAA mapping study suffice? Med Phys 2017; 44(6):2741. PMID: Not assigned. Abstract

Vega JEV, Halani SH, Yousefi S, Amrollahi F, Holder CA, Poisson LM, Griffith B, Eschbacher J, Nalisnik M, Olson JJ, Cooper LAD, and Brat DJ. Markers of progression in oligodendroglioma Lab Invest 2017; 97:438A-438A. PMID: Not assigned. Abstract

Vega JV, Halani S, Yousefi S, Amrol-Lahi F, Holder C, Poisson L, Griffith B, Eschbacher J, Nalisnik M, Olson J, Cooper L, and Brat D. The Role of NOTCH1 and PI3K Pathways In The Progression of Oligodendrogliomas J Neuropathol Exp Neurol 2017; 76(6):515-515. PMID: Not assigned. Abstract

Yeni YN, Dix MR, Xiao A, Oravec DJ, and Flynn MJ. Vertebral endplate and shell thickness measurement using digital tomosynthesis J Orthop Res 2017; 35PMID: Not assigned. Abstract

EMERGENCY MEDICINE

Al-Darzi W, Nowak R, Hudson M, Moyer ML, Jacobsen G, and McCord J. Ischemicst-segment changes on electrocardiogram in acute myocardial infarction-still common? J Gen Intern Med 2017; 32(2):S235-S236. PMID: Not assigned. Abstract

Al-Darzi W, Chaaban S, Abu Sayf A, Tirgari S, and Uduman J. Gaps in osmolal gap: A case of mistaken osmolal gap in a patient with diabetic ketoacidosis American Journal of Respiratory and Critical Care Medicine 2017; 195PMID: Not assigned. Abstract

Bhatt K, Borde A, Bien M, Flannigan S, Soward A, Kurz M, Hendry P, Zimny E, Lewandowski C, Velilla MA, Damiron K, Pearson C, Domeier R, Kaushik S, Feldman J, Rosenberg M, Jones J, Swor R, Rathlev N, and McLean S. Living in a low socioeconomic status neighborhood increases risk of developing clinically significant ptsd symptoms after motor vehicle collision: Results of a prospective cohort study Biological Psychiatry 2017; 81(10):S84-S84. PMID: Not assigned. Abstract

Binz S, Miller J, Robell N, Calo S, and Levy P. Antihypertensive medication effect on cerebral blood flow Neurocritical Care 2017; 27(2):S238. PMID: Not assigned. Abstract

Borde A, Bien M, Flannigan S, Soward A, Kurz M, Hendry P, Zimny E, Lewandowski C, Velilla MA, Damiron K, Pearson C, Domeier R, Kaushik S, Feldman J, Rosenberg M, Jones J, Swor R, Rathlev N, Peak D, Lee D, and McLean S. Post traumatic stress disorder outcomes at six months in african americans vs. european americans experiencing motor vehicle collison Biological Psychiatry 2017; 81(10):S85-S85. PMID: Not assigned. Abstract

Brown P, AbdulHamid A, Eapen A, Elbanna A, Greib BJ, Vahia A, and Miller J. Severely elevated blood pressure in the emergency department is an independent predictor of 6 and 12 month cardiovascular events J Gen Intern Med 2017; 32(2):S315-S316. PMID: Abstract

Caldwell MT, Polk H, Hambrick NJ, Vallee P, Robinson A, Goyal N, Manteuffel J, and Guetterman T. Exploring women's acceptance of a contraception intervention in the emergency department: A mixed methods study Acad Emerg Med 2017; 24:S165. PMID: Not assigned. Abstract

Calo S, Jaehne AK, Keenan KA, Xu J, Tawil B, Thompson R, Knight RA, Miller J, Lewandowski C, and Tavarekere NN. Deterioration in recombinant tissue plasminogen activator after repeated freezing and thawing cycles for thromboelastography Stroke 2017; 48PMID: Not assigned. Abstract

Harrison M, Assar S, Saeed A, and Li J. Death by kayexalate: Intestinal necrosis in the treatment of hyperkalemia J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

113 Hrabec D, Solomon R, McCord J, Hudson M, Moyer M, and Nowak R. The duration of presenting symptoms does not aid in the diagnosis of acute myocardial infarction Acad Emerg Med 2017; 24:S88-S89. PMID: Not assigned. Abstract

Jaehne AK, Chen Y, Schoenling A, Gill JK, Deledda J, Poisson L, and Rivers EP. Sepsis-3 the dysregulated host response and cytokine changes Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Moyer M, Jacobsen G, and McCord J. How often does troponin elevation identify acute myocardial infarction in the emergency department? J Am Coll Cardiol 2017; 69(11):1191-1191. PMID: Not assigned. Abstract

Joseph NR, Ali M, Harrison M, and Uduman J. Under the radar: Bilateral phrenic nerve palsy as a cause of progressive dyspnea Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Keene S, Miller J, Price CL, Thompson R, Calo S, Levy P, and Lewandowski C. Cerebral blood flow response to fluid challenge in acute ischemic stroke Acad Emerg Med 2017; 24:S193. PMID: Not assigned. Abstract

Linnstaedt S, Jung L, Zhou C, Mauck M, Kurz M, Zimny E, Pearson C, Hendry P, and McLean S. Genetic variants in the circadian rhythm pathway predict ptsd symptoms following trauma exposure Biological Psychiatry 2017; 81(10):S365-S366. PMID: Not assigned. Abstract

Linnstaedt S, Riker K, Kutchko K, Lackey L, Kurz M, Lewandowski C, Pearson C, Hendry P, Laederach A, and McLean S. Fkbp5 variant rs3800373 alters fkbp5 rna secondary structure and prevents stress-induced micro- rna- 320a downregulation of fkbp5, resulting in glucocorticoid resistance and increased vulnerability to chronic posttraumatic pain Biological Psychiatry 2017; 81(10):S324-S324. PMID: Not assigned. Abstract

Linnstaedt S, Rueckeis C, Riker K, Yu S, Chen C, King T, Lewandowski C, Hendry P, Pearson C, Kurz M, Damiron K, Domeier R, Liberzon I, and McLean S. Microrna-19b acts as a sex-dependent regulatory hub for ptsd and chronic widespread pain development following trauma exposure Biological Psychiatry 2017; 81(10):S275- S275. PMID: Not assigned. Abstract

Linnstaedt S, Yu S, Chen C, Kurz M, Pearson C, Hendry P, Lewandowski C, Domeier R, Damiron K, and McLean S. Expression levels of xist rna predict ptsd and chronic pain outcomes in women experiencing motor vehicle collision Biological Psychiatry 2017; 81(10):S137-S137. PMID: Not assigned. Abstract

Lipari V, Mashiba M, Mendiratta V, Lawler S, and Gibbs J. Observation unit utilization in decompensated heart failure and clinical predictors for appropriate triage J Gen Intern Med 2017; 32(2):S256. PMID: Not assigned. Abstract

Mashiba M, Lawler S, Mendiratta V, Lipari V, Georgie F, Nona P, and Gibbs J. Overutilization of the observation unit for decompensated heart failure J Gen Intern Med 2017; 32(2):S260. PMID: Not assigned. Abstract

McRae M, Van Veen T, Binz S, Calo S, Rose KR, Robichaud A, and Miller J. Derivation of patient decision tool for sore throat Acad Emerg Med 2017; 24:S116-S117. PMID: Not assigned. Abstract

Miller J, Kinni H, Nowak R, Reed B, Moyer M, DiSomma S, Nanayakkara P, and Levy P. Hemodynamic disturbances in patients with transient ischemic attack Acad Emerg Med 2017; 24:S128. PMID: Not assigned. Abstract

Morris DC, Cheung WL, Chopp M, Zhang T, and Zhang Z. Beta-aminoisobutyric induces neurite outgrowth in primary cortical neurons Acad Emerg Med 2017; 24:S195. PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Zhang T, Lu M, and Zhang ZG. Reactive gliosis improves outcome in an aged rat model of embolic stroke Stroke 2017; 48PMID: Not assigned. Abstract

Noll S, Lawler S, McCord J, Hudson M, Moyer M, Jacobsen G, and Nowak R. Short-term prognostic utility of low, intermediate, and high heart scores in patients presenting to the emergency department with possible acute myocardial injury Acad Emerg Med 2017; 24:S53. PMID: Not assigned. Abstract

Nowak R, Al-Darzi W, Noll S, Hudson M, Moyer M, Jacobsen G, and McCord J. Decreasing ischemic electrocardiocraphic changes in patients diagnosed with acute myocardial infarction in the era of high sensitivity troponin assays Acad Emerg Med 2017; 24:S18. PMID: Not assigned. Abstract

114 Nowak R, Jain T, Hrabec D, Moyer M, Hudson M, Jacobsen G, and McCord J. Elevated troponin values in the emergency department: Most often not associated with acute myocardial infarction Acad Emerg Med 2017; 24:S253. PMID: Not assigned. Abstract

Nowak RM, Disomma S, Nanayakkara P, Reed B, Moyer M, Millis S, and Levy P. Presenting emergency department hemodynamic phenotypes of acute heart failure patients Eur J Heart Fail 2017; 19:46. PMID: Not assigned. Abstract

Samuel G, Baltarowich L, Albujoq K, Chaaban S, Usman M, and Ouellette D. Acetaminophen overdose in a third trimester pregnancy Chest 2017; 152(4):A379. PMID: Not assigned. Abstract

Schoenling A, Hamam M, Jaehne AK, Calo S, Gill J, Krupp S, and Rivers EP. Emergency department triage blood glucose levels: Outcomes implications in patients with severe sepsis and septic shock Acad Emerg Med 2017; 24:S240. PMID: Not assigned. Abstract

Siddiqui M, Vahia AT, Stahl V, and Miller J. Severely elevated blood pressure in the emergency department is associated with short-term stroke risk Acad Emerg Med 2017; 24:S128-S129. PMID: Not assigned. Abstract

Solomon R, Nowak R, Hudson M, Moyer M, and McCord J. Is duration of symptoms predictive of acute myocardial infarction? J Am Coll Cardiol 2017; 69(11):247-247. PMID: Not assigned. Abstract

Vahia AT, Siddiqui M, Stahl V, Brody A, Levy P, and Miller J. Severely elevated blood pressure in the emergency department is an independent predictor of 6 and 12 month cardiovascular events Acad Emerg Med 2017; 24:S8. PMID: Not assigned. Abstract

FAMILY MEDICINE

Bhan A, Kulkarni P, Honasoge M, Palnitkar S, Qiu SJ, and Rao DS. Comparison of bone histomorphometry in hypophosphatemia and vitamin D deficiency osteomalacia Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

GLOBAL HEALTH INITIATIVE

Parke D, Plum A, Prentiss T, Zervos J, Dankerlui DN, and Kaljee L. Evaluation of an international trainee exchange program developed by the global health initiative at henry ford health system Ann Glob Health 83(1):131. PMID: Not assigned. http://www.annalsofglobalhealth.org/article/S2214-9996 (17)30353-3/abstract

INTERNAL MEDICINE

Allergy and Immunology

Mann ET, Havstad SL, Sitarik A, Bellemore SM, Levin AM, Lynch SV, Ownby DR, Johnson CC, Lukacs NW, Zoratti EM, Woodcroft KJ, and Bobbitt KR. Characterization of basophils in infants in the microbes, allergy, asthma and Pets (MAAP) birth cohort J Allergy Clin Immunol 2017; 139(2):AB168. PMID: Not assigned. Abstract

Orandi D, Havstad S, Sitarik A, Bobbitt K, Jones K, Levin A, Lukacs N, Lynch SV, Wegienka G, Woodcroft K, Ownby D, Johnson C, and Zoratti E. An analysis of potential associations between delivery mode and dog- keeping to basophil FCER1 and activation marker expression during infancy J Allergy Clin Immunol 2017; 139(2):AB167. PMID: Not assigned. Abstract

Sorkness RL, Zoratti E, Kattan M, Gergen PJ, Evans M, and Visness C. Obstructive phenotype as a predictor of asthma control and stability in children Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Cardiology/Cardiovascular Research

Abdelrahim E, Eng M, Gorgis S, Mawri S, Wang DD, Greenbaum A, Mahan M, Wyman J, Paone G, and O'Neill W. Predictors of late bleeding in the tavr population J Am Coll Cardiol 2017; 69(11):1298-1298. PMID: Not assigned. Abstract

115 Al Adas Z, Miller D, Weaver M, Shepard A, Nypaver TJ, Nour K, Balraj P, and Kabbani L. Cerebrovascular injuries are commonly found in acute type b aortic dissections and are associated with blood pressure derangements and poor outcome J Vasc Surg 2017; 66(2):E28-E28. PMID: Not assigned. Abstract

Alaswad K, Khandelwal A, Schreiber T, Lombardi W, and O'Neill W. Role of hemodynamic support in high risk pci patients with left ventricular ejection fraction ef >35% Catheter Cardiovasc Interv 2017; 89:S45-S46. PMID: Not assigned. Abstract

Al-Darzi W, Nowak R, Hudson M, Moyer ML, Jacobsen G, and McCord J. Ischemicst-segment changes on electrocardiogram in acute myocardial infarction-still common? J Gen Intern Med 2017; 32(2):S235-S236. PMID: Not assigned. Abstract

Al-Darzi W, Parikh M, Aurora L, Mawri S, and Zweig B. Understanding arrhythmogenic right ventricular cardiomyopathy: Progression from diagnosis to demise Journal of Cardiac Failure 2017; 23(8):S94. PMID: Not assigned. Abstract

Al-Mallah MH, Ahmed A, Qureshi W, Elshawi R, Brawner C, Blaha M, Ahmed H, Ehrman J, Keteyian S, and Sakr S. Using machine learning to define the association between cardiorespiratory fitness and all-cause mortality: The fit (henry ford exercise testing) project J Am Coll Cardiol 2017; 69(11):1612-1612. PMID: Not assigned. Abstract

Anderson M, Morris L, Tang D, Batsides G, Kirlane A, Hanson I, Meraj P, Kapur N, and O'Neill W. Impella rp post approval study: First multi-center, prospective post market approval results for the impella rp in patients with right ventricular failure J Heart Lung Transplant 2017; 36(4):S64-S65. PMID: Not assigned. Abstract

Anderson M, O'Neill W, and Kapur N. Percutaneous right ventricular support with impella RP in severe right ventricular failure: Insights from impella RP clinical studies J Am Coll Cardiol 2017; 70(18):B43. PMID: Not assigned. Abstract

Annamalai S, Esposito M, Kuchibhotla S, Hall S, Schreiber T, O'Neill W, and Kapur N. The impella micro-axial flow catheter is safe and effective for treatment of myocarditis complicated by cardiogenic shock: An analysis from the global CVAD registry J Am Coll Cardiol 2017; 70(18):B212. PMID: Not assigned. Abstract

Aurora L, Abuzaanona A, Mawri S, Raheja S, Michaels A, and Williams C. Giant cell myocarditis: Importance of prompt diagnosis and management J Card Fail 2017; 23(8):S94-S95. PMID: Not assigned. Abstract

Azzalini L, Karatasakis A, Spratt J, Tajti P, Ybarra L, Benincasa S, Bellini B, Candilio L, Hidalgo F, Timmers L, Kraaijeveld A, Agostoni P, Roy J, Ramsay D, Weaver J, Knaapen P, Starcevic B, Ojeda S, Pan M, Alaswad K, Lombardi W, Rinfret S, Carlino M, Brilakis E, Colombo A, and Mashayekhi K. Subadventitial crossing and crushing to recanalize in-stent chronic total occlusions: A multicenter registry J Am Coll Cardiol 2017; 70(18):B11. PMID: Not assigned. Abstract

Basir M, Alqarqaz M, Alaswad K, and O'Neill W. Effects of mechanical circulatory support on coronary pressure in patients with critical coronary stenosis Catheter Cardiovasc Interv 2017; 89:S47. PMID: Not assigned. Abstract

Bryson TD, Gu X, Zhu L, Xu J, Peterson E, Yang XP, and Harding P. Overexpression of prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Chopra V, Paje D, Conlon A, Grant P, Kaatz S, Bernstein S, and Flanders S. Michigan risk score to predict picc- related venous thromboembolism J Hosp Med 2017; 12(s2)PMID: Not assigned. Abstract

Curtis R, Lee D, Garratt K, and Rowe S. Long-term events after intravascular ultrasound-vs non-intravascular ultrasound-guided percutaneous intervention Catheter Cardiovasc Interv 2017; 89:S93-S94. PMID: Not assigned. Abstract

Daimee U, Vermilye K, Schuger CD, Daubert JP, Zareba W, Rosero S, McNitt S, Polonsky S, Moss AJ, and Kutyifa V. Heart failure severity, inappropriate icd therapy, and novel icd programming: A MADIT-RIT sub-study Heart Rhythm 2017; 14(5):S498-S499. PMID: Not assigned. Abstract

116 Danek B, Karatasakis A, Hatem R, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Kandzari D, Lembo N, Patel M, Mahmud E, Choi J, Doing A, Lombardi W, Wyman RM, Toma C, Uretsky B, Garcia S, Moses J, Kirtane A, Ali Z, Karacsonyi J, Sandoval Y, Rangan B, Khalili H, Banerjee S, and Brilakis E. Incidence, treatment, and outcomes of coronary perforation during chronic total occlusion percutaneous coronary interventions: Insights from a multicenter registry Catheter Cardiovasc Interv 2017; 89:S49-S50. PMID: Not assigned. Abstract

Danek B, Karatasakis A, Hatem R, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Kandzari D, Lembo N, Patel M, Mahmud E, Choi J, Doing A, Lombardi W, Wyman RM, Toma C, Uretsky B, Garcia S, Moses J, Kirtane A, Ali Z, Karacsonyi J, Tajti P, Rangan B, Khalili H, Banerjee S, and Brilakis E. Application and outcomes of the hybrid approach to chronic total occlusion percutaneous coronary intervention: An update from progress cto (prospective global registry for the study of chronic total occlusion intervention) Catheter Cardiovasc Interv 2017; 89:S2-S4. PMID: Not assigned. Abstract

Eng M, Dee Wang D, Greenbaum A, Gheewala N, Aka T, Song T, Pantelic M, Keimig T, Hawasli H, Kendall B, Wyman J, Myers E, and O'Neill W. Prospective, randomized comparison of 3-dimensional computed tomography guidance versus tee data for left atrial appendage occlusion (pro3dlaao) J Am Coll Cardiol 2017; 70(18):B216. PMID: Not assigned. Abstract

Evans KL, Wirtz H, Li J, She RC, Maya J, Depre C, Hamer A, and Lanfear D. Genetics of heart rate observational study (genhrate) J Am Coll Cardiol 2017; 69(11):685-685. PMID: Not assigned. Abstract

Flaherty M, Khan A, and O'Neill W. Meta-analysis of early initiation of impella in acute myocardial infarction and cardiogenic shock J Am Coll Cardiol 2017; 70(18):B244. PMID: Not assigned. Abstract

Gindi R, and Parikh S. For the love of loeffler J Am Coll Cardiol 2017; 69(11):2348-2348. PMID: Not assigned. Abstract

Gupta RC, Singh-Gupta V, and Sabbah HN. Long-term therapy with elamipretide normalizes activation of the mitochondrial signal transducer and activator of transcription 3 (mstat3) in of left ventricular myocardium of dogs with chronic heart failure J Am Coll Cardiol 2017; 69(11):923-923. PMID: Not assigned. Abstract

Hansen JW, Foy A, Yadav P, Gilchrist I, Kozak M, Wang A, Wang DD, Eng M, Greenbaum A, and O'Neill W. Death and dialysis risk after transcatheter aortic valve replacement J Am Coll Cardiol 2017; 69(11):1212-1212. PMID: Not assigned. Abstract.

Hrabec D, Solomon R, McCord J, Hudson M, Moyer M, and Nowak R. The duration of presenting symptoms does not aid in the diagnosis of acute myocardial infarction Acad Emerg Med 2017; 24:S88-S89. PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Moyer M, Jacobsen G, and McCord J. How often does troponin elevation identify acute myocardial infarction in the emergency department? J Am Coll Cardiol 2017; 69(11):1191-1191. PMID: Not assigned. Abstract

Jain T, Wang DD, Eng M, Isley M, Paone G, Greenbaum A, and O'Neill W. Transcatheter mitral valve-in-ring implantation after failure of surgical mitral ring annuloplasty J Am Coll Cardiol 2017; 69(11):1262-1262. PMID: Not assigned. Abstract

Jain T, Wang DD, Abdelrahim E, Gorgis S, Eng M, Nemeh H, O'Neill W, and Greenbaum A. Impact of mitral clip implantation on left atrial appendage velocity J Am Soc Echocardiogr 2017; 30(6):B39. PMID: Not assigned. Abstract

Kamioka N, Babaliaros V, Morse M, Frisoli T, Iturbe JM, Corrigan F, Forcillo J, Caughron H, Dong A, Devireddy C, O'Neill W, Paone G, Dee Wang D, Thourani V, and Greenbaum A. Echocardiographic findings of transcatheter mitral valve-in-valve therapy vs. Re-do surgical MVR in patients with previous mitral prosthetic valves J Am Coll Cardiol 2017; 70(18):B208. PMID: Not assigned. Abstract

Kapur NK, Esposito M, Kuchibhotla S, Hall S, Schreiber T, and O'Neill W. The impella micro-axial flow catheter is safe and effective for treatment myocarditis complicated by cardiogenic shock: An analysis from the global cVA registry J Card Fail 2017; 23(8):S130-S131. PMID: Not assigned. Abstract

Karacsonyi J, Alaswad K, Hatem R, Karmpaliotis D, Jaffer F, Yeh R, Choi J, Toma C, Doing A, Uretsky B, Patel M, Mahmud E, Moses J, Kirtane A, Parikh M, Ali Z, Martinez-Parachini J, Karatasakis A, Danek B, Tajti P, Khalili H, Rangan B, Ungi I, Thompson C, Banerjee S, and Brilakis E. Use of the gaia guidewires in a contemporary multicenter registry of chronic total occlusion percutaneous coronary intervention Catheter Cardiovasc Interv 2017; 89:S54-S55. PMID: Not assigned. Abstract

117 Karacsonyi J, Alaswad K, Karmpaliotis D, Moses J, Kirtane A, Parikh M, Ali Z, Jaffer F, Yeh R, Kandzari D, Lembo N, Patel M, Mahmud E, Lombardi W, Choi J, Doing A, Wyman M, Toma C, Uretsky B, Martinez-Parachini JR, Karatasakis A, Danek B, Khalili H, Rangan B, Ungi I, Thompson C, Banerjee S, and Brilakis E. Treatment of left anterior descending coronary artery chronic total occlusion: Insights form a contemporary multicenter registry Catheter Cardiovasc Interv 2017; 89:S53-S54. PMID: Not assigned. Abstract

Kassier A, Tawney A, Nona P, and Ananthasubramaniam K. Impact of echo contrast agents on ventricular assist devices (vad) hemodynamics: Are they safe to use? J Am Coll Cardiol 2017; 69(11):1632-1632. PMID: Not assigned. Abstract

Khan J, Rogers T, Greenbaum A, Babaliaros V, and Lederman R. Intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (lampoon) during TMVR: First-in-human findings J Am Coll Cardiol 2017; 70(18):B24. PMID: Not assigned. Abstract

Khan J, Rogers T, Schenke W, Greenbaum A, Babaliaros V, Paone G, Ramasawmy R, Chen M, Herzka D, and Lederman R. Transcatheter pledget-assisted suture tricuspid annuloplasty (PASTA) J Am Coll Cardiol 2017; 70(18):B38. PMID: Not assigned. Abstract

Kittleson MM, Shah P, Lala A, McLean R, Pamboukian S, Horstmanshof D, Thibodeau J, Shah K, Lanfear D, Teuteberg J, Taddei-Peters W, Khalatbari S, Stevenson L, Mann D, Aaronson K, and Stewart G. Painting profiles of ambulatory advanced heart failure: A report from the revival registry J Heart Lung Transplant 2017; 36(4):S170-S170. PMID: Not assigned. Abstract

Kupsky D, Dee Wang D, Eng M, Gheewala N, Nakhle A, Georgie F, Shah R, Mahan M, Greenbaum A, and O'Neill W. Socioeconomic disparities in access for Watchman device insertion in patients with atrial fibrillation and at elevated risk of bleeding J Am Coll Cardiol 2017; 70(18):B177. PMID: Not assigned. Abstract

Lahiri MK, Singh G, Khan A, and Schuger CD. Successful subcutaneous implanted cardioverter-defibrillator therapy using alternate vector in a patient post-implantation of heartware left ventricular assist device Heart Rhythm 2017; 14(5):S226-S227. PMID: Not assigned. Abstract

Lala A, Ambardekar A, Estep J, Stehlik J, Mountis M, Haas D, Horstmanshof D, Thibodeau J, Shah K, Lanfear D, Teuteberg J, Taddei-Peters W, Khalatbari S, Stevenson L, Mann D, Aaronson K, and Stewart G. Slower gait speed as a measure of frailty tracks with intermacs profiles, quality of life and predicted mortality in ambulatory patients with advanced heart failure: A report from the revival registry J Heart Lung Transplant 2017; 36(4):S178-S179. PMID: Not assigned. Abstract

Mawri S, Basir MB, Fuller B, Guerrero M, Alfonso C, O'Neill B, Heldman A, Cohen M, Greenbaum A, and O'Neill V. Incidence of in-stent restenosis in pre-transcatheter aortic valve replacement percutaneous coronary intervention Catheter Cardiovasc Interv 2017; 89:S57. PMID: Not assigned. Abstract

Mawri S, Gildeh E, Joseph N, Rabbani B, and Zweig B. Cardiac Dysrhythmias and Neurological Dysregulation: Manifestations of Profound Hypomagnesemia Case Rep Cardiol 2017; 2017PMID: Not assigned. Abstract

Mawri S, Ali M, Elsheikh A, Abuzaanona A, Patel R, Koenig G, Zaidan M, Khandelwal A, Voeltz M, Kim H, O'Neill W, and Alaswad K. Comparison of an innovative hybrid closure technique versus conventional vascular closure strategy in large bore access during mechanical hemodynamic support for high risk percutaneous coronary intervention J Am Coll Cardiol 2017; 70(18):B98-B99. PMID: Not assigned. Abstract

Molina-Pallete GM, Kansagra J, and Brar I. Utilization of interferon gamma release assays (IGRAs) for the detection of latent tuberculosis infection (LTBI) at a tertiary care hospital Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Munie S, Carlin A, Keteyian S, and Kerrigan D. The relationship between reported exercise and medium term weight loss following laparoscopic bariatric surgery Surg Obes Relat Dis 2017; 13(10):S11-S12. PMID: Not assigned. Abstract

Nadeem O, Motwani A, Parikh S, Borgi J, and Hudson M. Acquired left ventricular outflow tract to right atrial fistula due to tricuspid valve endocarditis Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Nakhle A, Nasr Y, Laktineh A, and Parikh S. Cardiac involvement in hypereosinophilic syndrome J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

118 Nakhle A, and Schairer J. Acute coronary syndrome in a hemophilia patient: A clinical challenge J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Nketiah E, McCord J, and Koenig G. Cardiac electrical biomarker response during percutaneous coronary intervention J Am Coll Cardiol 2017; 69(11):1193-1193. PMID: Not assigned. Abstract

Noll S, Lawler S, McCord J, Hudson M, Moyer M, Jacobsen G, and Nowak R. Short-term prognostic utility of low, intermediate, and high heart scores in patients presenting to the emergency department with possible acute myocardial injury Acad Emerg Med 2017; 24:S53. PMID: Not assigned. Abstract

Nona P, Mittal A, Pattiala K, Brooks K, Moore MT, and Ananthasubramaniam K. Do cardiovascular health screening programs and focused counseling have impact on patient habits and lifestyle change? Early results of the heart smart screening program J Am Coll Cardiol 2017; 69(11):1815-1815. PMID: Not assigned. Abstract

Nowak R, Al-Darzi W, Noll S, Hudson M, Moyer M, Jacobsen G, and McCord J. Decreasing ischemic electrocardiocraphic changes in patients diagnosed with acute myocardial infarction in the era of high sensitivity troponin assays Acad Emerg Med 2017; 24:S18. PMID: Not assigned. Abstract

Nowak R, Jain T, Hrabec D, Moyer M, Hudson M, Jacobsen G, and McCord J. Elevated troponin values in the emergency department: Most often not associated with acute myocardial infarction Acad Emerg Med 2017; 24:S253. PMID: Not assigned. Abstract

Parsh J, Seth M, Green J, Sutton NR, Chetcuti S, Dixon S, Grossman PM, Khandelwal A, Dupree JM, and Gurm HS. Coronary artery perforations after contemporary percutaneous coronary interventions: Evaluation of incidence, risk factors, outcomes, and predictors of mortality Catheter Cardiovasc Interv 2017; 89(6):966-973. PMID: Not assigned. Abstract

Patel R, Abdelrahim E, Ali M, Desai N, Singh A, Sudasena D, Wang DD, Eng MH, O'Neill W, and Greenbaum A. Outcomes and their predictors in acute transcatheter aortic heart valve-in-transcatheter aortic heart valve therapy J Am Coll Cardiol 2017; 69(11):1990-1990. PMID: Not assigned. Abstract

Patel R, Ali M, Nair S, Alqarqaz M, Koenig G, Zaidan M, Kim H, O'Neill W, and Alaswad K. Innovative technique to achieve hemostasis with large bore access for percutaneous hemodynamic support devices J Am Coll Cardiol 2017; 69(11):1114-1114. PMID: Not assigned. Abstract

Perdoncin E, Seth M, Schreiber T, Khandelwal A, Dixon S, and Gurm H. Contemporary use and outcomes associated with rotational versus orbital atherectomy in percutaneous coronary interventions: Insights from the blue cross blue shield of michigan cardiovascular consortium (BMC2) J Am Coll Cardiol 2017; 70(18):B251. PMID: Not assigned. Abstract

Pozehl B, McGuire R, Duncan K, Kupzyk K, Norman J, Artinian N, Saval M, and Keteyian S. Effects of the HEART camp intervention on adherence to exercise in patients with heart failure J Card Fail 2017; 23(8):S88-S89. PMID: Not assigned. Abstract

Qureshi W, Ahmed A, Blaha M, Brawner C, Ehrman J, Kupsky D, Keteyian S, Ahmed H, and Al-Mallah M. Chronotropic incompetence and long-term risk of heart failure: The henry ford exercise testing project J Am Coll Cardiol 2017; 69(11):691-691. PMID: Not assigned. Abstract

Sabbah Hani HN, Gupta RC, Singh-Gupta V, Zhang K, Xu J, and Albrecht-Kuepper B. Neladenoson, a partial adenosine A1-receptor agonist, improves mitochondrial function in skeletal muscle of dogs with chronic heart failure Eur J Heart Fail 2017; 19:511. PMID: Not assigned. Abstract

Sabbah HN. Abnormalities of cardiolipin synthesis and remodeling in heart failure: A cornerstone of energy deprivation J Heart Lung Transplant 2017; 36(4):S186-S186. PMID: Not assigned. Abstract

Sabbah HN, Hartman JC, and Reardon J. Effects of acute intravenous infusion of nitroxyl donor BMS-986231 on left ventricular function and cardiac rhythm in anaesthetised dogs with intracoronary microembolisation-induced heart failure Eur J Heart Fail 2017; 19:7-8. PMID: Not assigned. Abstract

Sabbah HN. Improving quality of life in patients with chronic heart failure: Overcoming exercise intolerance Cardiology (Switzerland) 2017; 137:15. PMID: Not assigned. Abstract

119 Sabbah HN, and Gupta RC. Long-term therapy with elamipretide reverses abnormalities of cardiolipin synthesis and remodeling in left ventricular myocardium of dogs with chronic heart failure J Card Fail 2017; 23(8):S25-S26. PMID: Not assigned. Abstract

Sandoval Y, Karatasakis A, Danek B, Karacsonyi J, Karmpaliotis D, Alaswad K, Jaffer F, Yeh R, Patel M, Mahmud E, Kandzari D, Lembo N, Choi J, Lombardi W, Doing A, Wyman RM, Uretsky B, Garcia S, Toma C, Kirtane A, Moses J, Parikh M, Ali Z, Banerjee S, and Brilakis E. Frequency and outcomes of ad hoc versus planned chronic total occlusion percutaneous coronary intervention: Insights from a multicenter registry Catheter Cardiovasc Interv 2017; 89:S62-S63. PMID: Not assigned. Abstract

Schreiber T, Htun WW, Kaki A, Dixon S, Blank N, Meraj P, Grines C, and O'Neill W. Despite higher morbity and mortality risk women had similar outcomes and improvement in heart failure as men in complex PCI with impella hemodynamic support J Card Fail 2017; 23(8):S67-S68. PMID: Not assigned. Abstract

Shah R, Nasr Y, Raymond T, Khandelwal A, and Tita C. Proof is in the paclitaxel: Catheter directed intracoronary paclitaxel as salvage therapy for refractory cardiac allograft vasculopathy J Am Coll Cardiol 2017; 69(11):2462-2462. PMID: Not assigned. Abstract

Solomon R, Nowak R, Hudson M, Moyer M, and McCord J. Is duration of symptoms predictive of acute myocardial infarction? J Am Coll Cardiol 2017; 69(11):247-247. PMID: Not assigned. Abstract

Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Patel M, Mahmud E, Choi J, Burke N, Doing A, Toma C, Uretsky B, Holper E, Wyman RM, Lombardi W, Kandzari D, Lembo N, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Moses J, Kirtane AJ, Parikh M, Ali Z, Hatem R, Karatasakis A, Karacsonyi J, Danek BA, Rangan B, and Brilakis E. Utilization of the hybrid approach for percutaneous coronary interventions for chronic total occlusions: Update from a multicenter global registry J Am Coll Cardiol 2017; 70(18):B207. PMID: Not assigned. Abstract

Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Patel M, Mahmud E, Choi J, Burke N, Doing A, Toma C, Uretsky B, Holper E, Wyman RM, Lombardi W, Kandzari D, Lembo N, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Moses J, Kirtane AJ, Parikh M, Hatem R, Ali Z, Karatasakis A, Karacsonyi J, Danek BA, Rangan B, and Brilakis E. Prevalence, presentation and treatment of 'balloon undilatable' chronic total occlusions: Multicenter us experience J Am Coll Cardiol 2017; 70(18):B9-B10. PMID: Not assigned. Abstract

Tajti P, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh R, Patel M, Mahmud E, Choi J, Burke N, Doing A, Toma C, Uretsky B, Holper E, Wyman RM, Lombardi W, Kandzari D, Lembo N, Garcia S, Krestyaninov O, Khelimskii D, Koutouzis M, Tsiafoutis I, Moses J, Kirtane AJ, Parikh M, Ali Z, Hatem R, Karatasakis A, Karacsonyi J, Danek BA, Rangan B, and Brilakis E. Retrograde CTO PCI of native coronary arteries via left internal mammary artery grafts: Insights from a multicenter US registry J Am Coll Cardiol 2017; 70(18):B189. PMID: Not assigned. Abstract

Teuteberg JJ, and O'Neill W. Association between the use of invasive hemodynamic monitoring and outcomes with percutaneous left ventricular support: A call for standardization? J Heart Lung Transplant 2017; 36(4):S59-S59. PMID: Not assigned. Abstract

Ting C, Singh A, Solomon R, Murad A, Woolley R, and Michaels A. No maggic in predicting heart failure readmissions J Am Coll Cardiol 2017; 69(11):788-788. PMID: Not assigned. Abstract

To L, Jantz A, Hencken L, William C, and Nemeh H. Safety and efficacy of four factor prothrombin complex concentrate for the reversal of warfarin in lvad patients prior to heart transplantation J Heart Lung Transplant 2017; 36(4):S365-S365. PMID: Not assigned. Abstract

Endocrinology and Metabolism

Bhan A, Kulkarni P, Honasoge M, Palnitkar S, Qiu SJ, and Rao DS. Comparison of bone histomorphometry in hypophosphatemia and vitamin D deficiency osteomalacia Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, and Ruff VA. Modeling-and remodeling-based bone formation in the anabolic vs. antire-sorptive (ava) study in postmeno-pausal women with osteoporosis Osteoporosis Int 2017; 28:S191-S192. PMID: Not assigned. Abstract

120 Gopie SV, Ramakrishnan R, Rao SD, and Thudi V. Progressive scarring alopecia due to extensive subcutaneous scalp calcifications in a patient with pseudohypoparathyroidism (PHP) Endocrine Reviews 2017; 38(3)PMID: Not assigned. Abstract

Hodish I, Johnson M, Bashan E, Kruger DF, Bhargava A, and Bergenstal RM. Automated frequent insulin dosage titrations to enhance therapy effectiveness; lessons from the d-Nav® insulin guidance Diabetologia 2017; 60(1):S303. PMID: Not assigned. Abstract

Simon R, Hejab A, and Lahiri S. Pheochromocytoma presenting as takotsubo cardiomyopathy: A nearly missed diagnosis in the absence of hypertension Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

Thudi V, and Levy S. Scapular metastasis as an initial diagnosis of papillary thyroid cancer Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

Gastroenterology

Al-Darzi W, El-Atrache M, Georgie F, Sadiq O, Singla S, Fernandez C, Pompa R, Galusca D, Yoshida A, and Jafri SM. Risk factors and outcomes of intracardiac thrombosis during orthotopic liver transplantation Am J Transplant 2017; 17:582. PMID: Not assigned. Abstract

Bourliere M, Gane EJ, Jacobson I, Gordon SC, Sulkowski MS, McNabb BL, Chen F, Dvory-Sobol H, McNally J, Brainard DM, Subramanian M, Ramji A, Zeuzem S, Agarwal K, and Reddy KR. Long-term follow up of patients with chronic HCV and no or minimal fibrosis shows low risk for liver-related morbidity and mortality after achieving svr with daa-based therapy: Results from the gilead SVR registry Hepatology 2017; 66:518A-519A. PMID: Not assigned. Abstract

Bourliere M, Gordon SC, Schiff ER, Tran TT, Ravendhran N, Landis CS, Hyland RH, Zhang J, Dvory-Sobol H, Stamm LM, Brainard DM, McHutchison JG, Serfaty L, Thompson AJ, Sepe TE, Curry MP, Reddy KR, and Manns MP. SOF/VEL/VOX for 12 weeks in NS5A-inhibitor experienced HCV-infected patients: Results of the deferred treatment group in the phase 3 POLARIS-1 study Hepatology 2017; 66:633A-634A. PMID: Not assigned. Abstract

Dusheiko G, Lim J, Liou I, Tafazzoli A, Deniz B, Thibault CST, Gordon S, and Nguyen MH. Cost-effectiveness analysis of first-line administration of tenofovir alafenamide (taf), a novel nucleotide reverse transcriptase inhibitor (nrti), for the management of chronic hepatitis b (chb) in the united states (US) Value in Health 2017; 20(5):A78-A78. PMID: Not assigned. Abstract

Glynn M, Jantz A, Summers B, Salgia R, and Sulejmani N. Safety of statin therapy after liver transplantation Am J Transplant 2017; 17:585. PMID: Not assigned. Abstract

Gordon SC, Lim J, Liou I, Ozbay AB, Meyer N, Dusheiko G, and Nguyen MH. Rising prevalence of osteoporosis and bone fracture in chronic hepatitis B patients: A United States population-based study Hepatol Int 2017; 11(1):S272- S273. PMID: Not assigned. Abstract

Gordon SC, Ahmed A, Saab S, Dieterich DT, Wong RJ, Kugelmas M, Brown KA, and Younossi ZM. Health outcomes associated with sofosbuvir- based single-tablet regimens for initial and re-treatment of chronic hepatitis c in the US Hepatology 2017; 66:635A-636A. PMID: Not assigned. Abstract

Hirschfield GM, Bowlus CL, Harrison SA, Galambos MR, Borg BB, Gordon SC, Gitlin N, Hassanein TI, Odin JA, Bacon B, Bernstein DE, Vierling JM, Steinberg A, Choi YJ, Varga M, Martin R, McWherter C, Boudes P, and Jones D. Treatment efficacy and safety of low dose seladelpar, a selective PPAR-δ agonist, in patients with primary biliary cholangitis: Twelve-week interim analysis of an international, randomized, dose ranging, phase 2 study Hepatology 2017; 66(6):1256A-1257A. PMID: Not assigned. Abstract

Hofmeister MG, Xing J, Moorman AC, Rupp LB, Gordon SC, Boscarino JA, Schmidt MA, Daida YH, Lu M, Teshale EH, Holmberg SD, Spradling PR, and Investigators CH. Health outcomes among surveyed patients infected with hepatitis C in the Chronic Hepatitis Cohort Study (CHeCS) Hepatology 2017; 66:559A-559A. PMID: Not assigned. Abstract

Hou J, Weatherly J, Sellin J, Kaur M, Metwally M, Vrabie R, Ali T, Kaurk N, Gasche C, Drazain N, Oberai R, Nguyen A, Weaver A, Siegel C, and Melmed G. Feasibility of screening for anemia using the crohn's and colitis foundation anemia care pathway in ibd qorus Inflamm Bowel Dis 2017; 23:S46-S47. PMID: Not assigned. Abstract

121 Iqbal U, Siddiqui MA, Chaudhary A, and Anwar H. Gangrenous gastritis: Unusual cause of upper GI bleeding J Gen Intern Med 2017; 32(2):S503. PMID: Not assigned. Abstract

Iqbal U, Siddiqui MA, Chaudhary A, Anwar H, and Alvi M. Severe hypertriglyceridemia induced acute pancreatitis: Management strategy in a rural setup J Gen Intern Med 2017; 32(2):S387. PMID: Not assigned. Abstract

Jesse M, Rebhan N, Yoshida A, Moonka D, Eshelman A, Abouljoud M, and Rizzari M. Substance abuse in acute liver failure: Time to talk about opiates Am J Transplant 2017; 17:240. PMID: Not assigned. Abstract

Kaurala SA, Veve M, Van Lare J, Mansour JS, Andrews M, Brown KA, and Davis S. Measures of adherence to HCV therapy in a specialty pharmacy setting and association with NON-SVR Hepatology 2017; 66:594A-594A.PMID: Not assigned. Abstract

Lawitz E, Landis CS, Maliakkal BJ, Bonacini M, Ortiz-Lasanta G, Zhang J, Mogalian E, De-Oertel S, Osinusi AO, Brainard DM, McHutchison JG, Flamm SL, Gordon SC, and Gane EJ. Safety and efficacy of treatment with once- daily ledipasvir/sofosbuvir (90/400 mg) for 12 weeks in genotype 1 hcv-infected patients with severe renal impairment Hepatology 2017; 66:848A-848A. PMID: Not assigned. Abstract

Lawitz E, Poordad F, Anderson L, Vesay M, Liu H, Fernsler D, Asante-Appiah E, Hanna GJ, Robertson M, Barr E, Butterton JR, Kowdley KV, Hassanein TI, Sahota AK, Gordon SC, and Yeh WW. C-BREEZE 1: Efficacy and safety of ruzasvir 60 mg plus uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis c virus (HCV) genotype (GT)1, 2, 3, 4, or 6 infection Hepatology 2017; 66:631A-632A. PMID: Not assigned. Abstract

Li J, Gordon SC, Rupp LB, Zhang TL, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida Y, and Lu M. Does Hepatitis C eradication lead to improved glucose metabolism, renal and cardiovascular outcomes in diabetic patients? Hepatology 2017; 66:525A-525A. PMID: Not assigned. Abstract

Li J, Zhang TL, Gordon SC, Rupp LB, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida YH, Lu M, and For The Chronic Hepatitis Cohort S. Impact of sustained virological response on incidence of type 2 diabetes in hepatitis c patients Hepatology 2017; 66:531A-531A. PMID: Not assigned. Abstract

Lopez Plaza I, Eisenbrey A, Raoufi M, Yoshida A, and Moonka D. Treating refractory liver allograft rejection with photopheresis Am J Transplant 2017; 17:784. PMID: Not assigned. Abstract

Lu M, Zhou YR, Haller I, Romanelli R, VanWormer JJ, Rodriguez CV, Anderson H, Boscarino JA, Schmidt MA, Daida Y, Sahota AK, Vincent J, Bowlus CL, Lindor KD, Zhang T, Trudeau S, Li J, Rupp LB, Gordon SC, and Fibrotic Liver Dis FC. Epidemiologic trends and treatment survival benefits in a US cohort of patients with primary biliary cholangitis (PBC) Hepatology 2017; 66:157A-157A. PMID: Not assigned. Abstract.

Markus J, Bukannan A, Kashat B, and Salgia R. Contemporary outcomes and risk factors of acute graft- versus- host disease after liver transplant Am J Transplant 2017; 17:294. PMID: Not assigned. Abstract

Moonka D, Nagai S, Harper A, and Salgia R. The impact of the donor risk index on tumor free survival in patients undergoing liver transplantation with hepatocellular carcinoma Am J Transplant 2017; 17:433. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Brown K, Patel A, Yoshida A, and Abouljuod M. An argument for expanding the simultaneous liver and kidney transplant criteria: Validity of the new UNOS allocation policy Am J Transplant 2017; 17:772-773. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Patel A, Brown K, Yoshida A, and Abouljoud M. Rapid deterioration of pre-transplant kidney function requiring dialysis is a prognostic factor in liver transplant alone Am J Transplant 2017; 17:776. PMID: Not assigned. Abstract

Nguyen MH, Lim J, Liou I, Ozbay AB, Fraysse J, Costa L, Gordon SC, and Dusheiko G. Chronic hepatitis B patients have increasing prevalence and incidence of chronic kidney disease compared to matched non-chronic hepatitis B controls: Results of a real-world analysis of 1,65,594 patients in the United States Hepatol Int 2017; 11(1):S192- S193. PMID: Not assigned. Abstract

Nguyen MH, Lim J, Ozbay AB, Fraysse J, Liou I, Moore-Schiltz L, Dusheiko G, and Gordon SC. Increasing age and comorbidities of chronic hepatitis B patients in the US: A longitudinal analysis of a diverse US populationbased cohort of 44,026 CHB patients over 10 years Hepatol Int 2017; 11(1):S193-S194. PMID: Not assigned. Abstract

122 Parekh R, and Kaur N. Colonic dysplasia in patients with inflammatory bowel disease undergoing liver transplantation for primary sclerosing cholangitis Inflamm Bowel Dis 2017; 23:S56-S56. PMID: Not assigned. Abstract

Parekh R, Segovia M, and Kaur N. Course of inflammatory bowel disease activity in primary sclerosing cholangitis patients undergoing liver transplantation Am J Transplant 2017; 17:782. PMID: Not assigned. Abstract

Rana S, Bhan A, and Salgia R. Successful management of patients with co-existent autoimmune hepatitis and graves' disease Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

Safwan M, Abouljoud M, and Salgia R. Outcome of liver transplantation in patients with prior bariatric surgery Am J Transplant 2017; 17:580-581. PMID: Not assigned. Abstract

Selim R, Abdulhamid A, Shyamraj A, Watson A, Tang J, and Jafri SM. Statins in liver transplant recipients: Rates of use, mortality and rejection Am J Transplant 2017; 17:585. PMID: Not assigned. Abstract

Selim R, Getzen T, and Moonka D. Outcomes of TIPS for ascites as a function of baseline renal function Hepatology 2017; 66:952A-952A. PMID: Not assigned. Abstract

Takahashi K, Nagai S, Safwan M, Putchakayala K, Collins K, Rizzari M, Yoshida A, Abouljoud M, and Jafri SM. Lactate level immediate post-liver transplantation is a predictor of early allograft dysfunction Am J Transplant 2017; 17:581. PMID: Not assigned. Abstract

Thompson A, Sarrazin C, Cooper CL, Manns MP, Reddy RK, Kowdley K, Dvory-Sobol H, Svarovskia E, Martin R, Doehle BP, Camus G, Stamm LM, Hyland RH, Brainard DM, Mo H, Gordon SC, Bourliere M, Zeuzem S, and Flamm SL. No impact of resistance-associated substitutions on the high efficacy of sofosbuvir-velpatasvir- voxilaprevir for 12 weeks in direct-acting antiviral-experienced patients: An integrated resistance analysis of the POLARIS-1 and POLARIS-4 studies J Gastroenterol Hepatol 2017; 32:109-110. PMID: Not assigned. Abstract

Wilson E, Davitkov P, Kwo PY, Kattakuzhy S, Qureshi K, Sundaram V, Naik S, Williams LA, Wolf J, Llewellyn J, Osinusi AO, Brainard DM, Gordon SC, Backus LI, and Kowdley KV. Real world effectiveness of 8 vs 12 weeks of ledipasvir/sofosbuvir (LDV/SOF) in blacks with HCV: A comparative analysis of clinical trials with real world cohorts Hepatology 2017; 66:608A-608A. PMID: Not assigned. Abstract

Vance RB, and Piraka C. Cold snare polypectomy is a safe and effective technique to remove large, partially circumferenctial duodenal polyps Gastroint Endosc 2017; 85(5):AB295. PMID: Not assigned. Abstract

Hematology-Oncology

Abdel-Rahman Z, Ali H, Favazza L, and Chitale D. Poor concordance between 21-gene expression assay recurrence score and all Magee equation recurrence scores in a consecutive cohort of patients treated for hormone receptor positive early breast cancer Breast 2017; 32:S87-S87. PMID: Not assigned. Abstract

Abdel-Rahman Z, Alkhatib Y, and Dabak V. A mysterious cause of chest pain J Gen Intern Med 2017; 32(2):S412. PMID: Not assigned. Abstract

Abdel-Rahman Z, Alsafadi K, Jabbour H, Mendiratta V, Alkhatib Y, and Donthireddy V. Hematology referrals for mild thrombocytopenia in a tertiary center in detroit: A step towards a standardized approach for referrals and testing Blood 2017; PMID: Not assigned. Abstract

Apolo AB, Ellerton J, Infante JR, Agrawal M, Gordon MS, Aljumaily R, Britten CD, Dirix L, Lee KW, Taylor MH, Schoffski P, Wang D, Ravaud A, Gelb A, Xiong J, Rosen G, and Patel MR. Avelumab treatment of metastatic urothelial carcinoma (mUC) in the phase 1b JAVELIN solid Tumor study: updated analysis with >= 6 months of follow-up in all patients Ann Oncol 2017; 28:2. PMID: Not assigned. Abstract

Apolo AB, Ellerton J, Infante JR, Agrawal M, Gordon MS, Aljumaily R, Britten CD, Dirix L, Lee KW, Taylor MH, Schõffski P, Wang D, Ravaud A, Gelb A, Xiong J, Rosen G, and Patel MR. Avelumab treatment of metastatic urothelial carcinoma (mUC) in the phase 1b JAVELIN solid Tumor study: Updated analysis with ≥6 months of follow- up in all patients Annals of Oncology 2017; 28:v300-v301. PMID: Not assigned. Abstract

Assar S, Nakhle A, Ali H, Saeed A, and Heidemann D. More holes than swiss cheese: Myxedema coma in a patient with iatrogenic hypothyroidism J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

123 Bazhenova L, Mehra R, Nagy T, Cavanna L, Lee JS, Han JY, Kim HK, Halmos B, Shum M, Schreeder M, Rybkin I, Badin F, Mena R, Janne PA, Christensen J, Tassell V, Chao R, Faltaos D, and Kim DW. Amethyst nsclc trial: Phase 2, parallel-arm study of receptor tyrosine kinase (rtk) inhibitor, mgcd265 in patients with advanced or metastatic non- small cell lung cancer (nsclc) with activating genetic alterations in mesenchymal-epithelial transition factor (met) Ann Oncol 2016; 27:1. PMID: Not assigned. Abstract

Farhan S, Neme K, Mikulandric N, Ruemenapp K, Trapp MA, Bazydlo M, Peres E, and Janakiraman N. Early donor chimerism in patients with myeloid malignancies undergoing stem cell transplantation using FluBu4 with and without busulfan pharmacokinetics compared to busulfan and cyclophosphamide Biol Blood Marrow Transplant 2017; 23(3):S271. PMID: Not assigned. Abstract

Gajra A, Ali H, Amiri KI, Karim NA, Matrana MR, Mulford D, Ong TJ, Sanford A, Santos E, Socinski M, Spigel DR, and Lilenbaum RC. Interim safety results from the phase 2 abound.Ps2 study evaluating nab-paclitaxel (nab-p) plus carboplatin (c) followed by nab-p monotherapy in patients (pts) with nsclc and an eastern cooperative oncology group (ecog) performance status (ps) 2 Ann Oncol 2016; 27:1. PMID: Not assigned. Abstract

Gopal AK, Ramchandren R, Gabrail NY, Patel MR, Wang D, Miller LL, Goel V, Chiang GG, Webster KR, Sperry S, Vallner DT, Casseday C, and Barton J. A Phase 1-2 dose-escalation and cohort- expansion study of eFT508, a selective, orally bioavailable inhibitor of MNK1 and MNK2, in patients with hematological malignancies Blood 2017; 130(Suppl 1):4624-4624. PMID: Not assigned. Abstract

Griggs JJ, Braun T, Severson DM, Layhe EM, Gorski DH, Breslin TM, and Henry NL. Clinical and nonclinical factors associated with confirmatory biopsy in metastatic breast cancer J Clin Oncol 2017; 35(8) PMID: Not assigned. Abstract

Griggs JJ, Braun T, Severson DM, Layhe EM, Gorski DH, Breslin TM, and Henry NL. Site variation in assessment of biomarkers on biopsy specimens in patients with metastatic disease J Clin Oncol 2017; 35(8) PMID: Not assigned. Abstract

Gucalp A, Danso MA, Elias AD, Bardia A, Ali HY, Potter D, Gabrail NY, Haley BB, Khong HT, Riley EC, Ervin L, Eisner JR, Baskin-Bey E, Moore WR, and Traina TA. Phase (Ph) 2 stage 1 clinical activity of seviteronel, a selective CYP17-lyase and androgen receptor (AR) inhibitor, in women with advanced AR+ triple-negative breast cancer (TNBC) or estrogen receptor (ER)+ BC: CLARITY-01 J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Harb WA, Edelman MJ, Chambers SK, Garland LL, Armour A, Wang D, Goss GD, and Sachdev J. Phase 1 dose escalation study of the folate receptor-targeted small molecule drug conjugate EC1456 J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Harb WA, Rosen LS, Wang D, Fakih M, Mahadevan D, Clemens W, Selvaggi G, Bosque S, Brown R, Alvis S, Champion B, and McElwaine-Johnn H. A phase I study of enadenotucirev (EnAd), an oncolytic Ad11/Ad3 chimeric group B adenovirus, in combination with nivolumab in tumors of epithelial origin J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Lupak O, Bazydlo M, Siddiqui F, Chang S, Coniglio B, and Wang D. Timing of percutaneous endoscopic gastrostomy (PEG) tube placement as supportive care in HNSCC patients (Pts) receiving concurrent chemoradiotherapy (CRT) J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Malik D, Kuriakose P, Philip J, Hejab A, Horbal A, and Mendiratta V. Evaluating the clinical utility of testing for autoimmune disorders in the setting of leukopenia/neutropenia in an ambulatory hematology clinic Blood 2017; PMID: Not assigned. Abstract

Nemunaitis J, Borghaei H, Akerley W, Gadgeel S, Spira A, Rybkin I, Faltaos D, Chen I, Christensen J, Potvin D, Velastegui K, Levisetti M, and Husain H. Phase 2 study of glesatinib or sitravatinib with nivolumab in non-small cell lung cancer (NSCLC) after checkpoint inhibitor therapy J Thorac Oncol 2017; 12(1):S1078. PMID: Not assigned. Abstract

Park K, Choi S, Ali H, Divine G, Bensenhaver J, Nathanson D, Proctor E, Petersen L, and Newman L. Clinicopathologic features and models predicting for high-risk 21-gene recurrence score (RS) are unreliable in predicting primary tumor downstaging with neoadjuvant chemotherapy (NACT) Ann Surg Oncol 2017; 24(1):S49- S50. PMID: Not assigned. Abstract

Putchakayala K, Skorupski S, Farhan S, Chaffins M, Ilias S, Pahari H, Collins K, Nagai S, and Abouljoud M. Graft-versus-host disease following deceased donor liver transplant Am J Transplant 2017; 17:783-784. PMID: Not assigned. Abstract

124 Rahman ZA, Philip J, Mohtadi O, Kahlon PS, and Donthireddy V. Effect of follow-up appointments and admission unit on readmissions in patient with cancer on chemotherapy: A tertiary center experience J Clin Oncol 2017; 35(15) PMID: Not assigned. Abstract

Sachdev JC, Edelman M, Harb W, Armour A, Wang D, and Starodub AN. Phase 1 dose-escalation study of the folic acid-tubulysin small-molecule drug conjugate (smdc) folate-tubulysin ec1456: Study update Ann Oncol 2016; 27:1. PMID: Not assigned. Abstract

Saeed A, Assar S, Ali H, and Heidemann D. Its not always dementia: A rare case of vzv encephalitis J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Selim R, Philip J, and Donthireddy V. Comparison of high dose methotrexate treatments in CNS lymphoma patients: The Henry Ford experience J Clin Oncol 2017; 35(15) PMID: Not assigned. Abstract

Sood SL, Cheng D, Shapiro AD, Kessler CM, Key NS, Quon DV, Eyster ME, Manco-Johnson MJ, Kempton CL, Cuker A, Ragni MV, Gill JC, Kuriakose P, Von Drygalski A, Kouides P, Escobar MA, Wheeler AP, Wang T, Leissinger CA, Galdzicka S, and Konkle B. Chronic kidney disease in the U.S. Hemophilia population: A cohort study Blood 2017; 130(Suppl 1):2359-2359. PMID: Not assigned. Abstract

Swinnen LJ, Flowers CR, Wang D, Reid E, Fowler N, Cordero J, Dunbar M, Enschede S, Nolan C, Petrich AM, Ross J, Salem AH, Verdugo M, Wong S, Zhou L, Kozloff M, Nastoupil L, and De Vos S. Venetoclax (VEN), bendamustine (B) and rituximab (R) in patients (PTs) with relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL): Final results of a phase I study Hematol Oncol 2017; 35:90. PMID: Not assigned. Abstract

Werner T, Heist R, Carvajal R, Adkins D, Alva A, Goel S, Hong D, Bazhenova L, Saleh M, Siegel R, Kyriakopoulos C, Blakely C, Eaton K, Lauer R, Wang D, Schwartz G, Neuteboom S, Potvin D, Faltaos D, Chen I, Christensen J, Levisetti M, Chao R, and Bauer T. A Study of MGCD516, a receptor tyrosine kinase (RTK) inhibitor, in molecularly selected patients with NSCLC or other advanced solid tumors J Thorac Oncol 2017; 12(1):S1068-S1069. PMID: Not assigned. Abstract

Williams A, Goldberg W, Varkas T, and Ryan M. Distress screening for program building: Similarities and differences among patient populations Psycho-Oncology 2017; 26:100. PMID: Not assigned. Abstract

Yardley D, Coleman R, Conte P, Cortes J, Brufsky A, Shtivelband M, Young R, Bengala C, Ali H, Eakel J, Schneeweiss A, Merino LD, Wilks S, O'Shaugnessy J, Gluck S, Li H, Beck R, Barton D, and Harbeck N. nab- paclitaxel plus carboplatin or gemcitabine vs gemcitabine/carboplatin as first-line treatment for patients with triple- negative metastatic breast cancer: Results from the randomized phase 2 portion of the tnAcity trial Cancer Research 2017; 77:3. PMID: Not assigned. Abstract

Hypertension and Vascular Research

Ares G, Caceres P, Kassem KM, and Ortiz PA. Stimulation of sweet taste receptors expressed in the kidney enhance surface NKCC2 levels in thick ascending limbs (TALs) FASEB Journal 2017; 31(1) PMID: Not assigned. Abstract

Bryson TD, Gu X, Zhu L, Xu J, Peterson E, Yang XP, and Harding P. Overexpression of prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Burgraff N, Pavlov T, Levchenko V, Geurts A, Forster H, Staruschenko A, Hodges M, and Palygin O. Altered pH homeostasis and acoustic induced seizures associated with KCNJ16 loss of function mutation FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Ilatovskaya D, Levchenko V, Pavlov TS, and Staruschenko A. Effects of dietary sodium content on cysts formation in ARPKD FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Jaykumar AB, Caceres P, Henson EL, Beierwaltes WH, and Ortiz PA. Deletion of ALMS1 (alstrom syndrome 1) enhances salt-sensitive hypertension, and induces insulin resistance and obesity in rats FASEB Journal 2017; 31(1) PMID: Not assigned. Abstract

Kassem KM, Ares G, and Ortiz P. A role for sweet taste receptors (T1R2/T1R3) in fructose-induced increase in nkcc2 phosphorylation in thick ascending limbs (TALs) FASEB Journal 2017; 31(1) PMID: Not assigned. Abstract

125 King-Medina KN, Jaykumar A, and Ortiz P. Exaggerated salt-sensitive hypertension in the ALMS1 (alstrom syndrome 1) knockout rat FASEB Journal 2017; 31(1) PMID: Not assigned. Abstract

Mendez M. Imaging renin granule exocytosis in Juxtaglomerular cells by Total internal reflection (TIRF) microscopy FASEB Journal 2017; 31(1) PMID: Not assigned. Abstract

Pan GD, Deshpande M, and Palaniyandi SS. Decreased aldehyde dehydrogenase (aldh)2 activity contributes to coronary endothelial dysfunction in diabetic cardiomyopathy J Mol Cell Cardiol 2017; 112:135-136. PMID: Not assigned. Abstract

Ziaul Haque M, McIntosh VJ, Mohammad RM, Abou Samra AB, and Lasley RD. Cholesterol depletion increased cardiomyocyte contractility associated with phosphorylation of cytosolic AKT FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Infectious Diseases

Gallant J, Lazzarin A, Mills A, Orkin C, Podzamczer D, Tebas P, Girard PM, Brar I, Daar E, Wohl D, Rockstroh J, Wei X, White K, Martin H, Quirk E, and Cheng A. A Phase 3 randomized controlled clinical trial of bictegravir in a fixed dose combination, B/F/TAF, vs ABC/DTG/3TC in treatment-naive adults at Week 48 J Int AIDS Soc 2017; 20:103-104. PMID: Not assigned. Abstract

Jebastin J, Tibbetts R, Pritt BS, Boxwalla A, and Samuel L. Chronic obstructive pulmonary disease exacerbation that worsened with standard treatment Clin Infect Dis 2017; 64(12):1798-1800. PMID: Not assigned. Abstract

Molina-Pallete GM, Kansagra J, and Brar I. Utilization of interferon gamma release assays (IGRAs) for the detection of latent tuberculosis infection (LTBI) at a tertiary care hospital Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Nephrology

Al-Abid B, Sohaney R, Alamiri K, Kumbar L, Soi V, and Yee J. Dementia and catheter dysfunction as under identified and documented risk factors for catheter related blood stream infections Am J Kidney Dis 2017; 69(4):A19- A19. PMID: Not assigned. Abstract

Al-Abid B, and Uduman J. Hyperkalemia induced syncope Blood Purification 2017; 43(1-3):251-252. PMID: Not assigned. Abstract

Al Adas Z, Nypaver T, Shepard AD, Weaver MR, Malinzak L, Alamiri, K, Patel A, and Kabbani L. Kidney transplant increases the risk of ipsilateral critical limb ischemia J Vasc Surg 2017; 65(6):117S. PMID: Not assigned. Abstract

Al-Darzi W, Chaaban S, Abu Sayf A, Tirgari S, and Uduman J. Gaps in osmolal gap: A case of mistaken osmolal gap in a patient with diabetic ketoacidosis American Journal of Respiratory and Critical Care Medicine 2017; 195PMID: Not assigned. Abstract

Harrison M, Assar S, Saeed A, and Li J. Death by kayexalate: Intestinal necrosis in the treatment of hyperkalemia J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Joseph NR, Ali M, Harrison M, and Uduman J. Under the radar: Bilateral phrenic nerve palsy as a cause of progressive dyspnea Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Kumbar L, Zasuwa G, Zaborowicz M, Taylor A, and Yee J. Post-angioplasty changes in venous access pressure ratio is a novel diagnostic tool predicting access failure Am J Kidney Dis 2017; 69(4):A60-A60. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Brown K, Patel A, Yoshida A, and Abouljuod M. An argument for expanding the simultaneous liver and kidney transplant criteria: Validity of the new UNOS allocation policy Am J Transplant 2017; 17:772-773. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Patel A, Brown K, Yoshida A, and Abouljoud M. Rapid deterioration of pre-transplant kidney function requiring dialysis is a prognostic factor in liver transplant alone Am J Transplant 2017; 17:776. PMID: Not assigned. Abstract

126 Patel A, and Prashar R. Does gender affect renal transplant outcomes? Am J Transplant 2017; 17:631-632. PMID: Not assigned. Abstract

Prashar R, Shah A, Stewart D, Williamson S, and Patel A. Bk polyoma virus and malignancy: Cause or co- incidence? Am J Transplant 2017; 17 :483. PMID: Not assigned. Abstract

Sonalika A, Muhammad F, Vini S, and Snigdha R. Lvad-a cause of cola-colored urine Am J Kidney Dis 2017; 69(4):A18-A18. PMID: Not assigned. Abstract

Thaxton S, Rouen P, Groh C, Li J, and Peterson E. Practice standards and health-related quality of life in kidney disease Am J Kidney Dis 2017; 69(4):A97-A97. PMID: Not assigned. Abstract

Winkelmayer W, Block G, Chertow G, Fishbane S, Komatsu Y, McCullough P, Pergola P, Rosenberger C, Williamson D, Yee J, Collins A, Khawaja Z, Sharma A, Zuraw Q, and Maroni B. The inno(2)vate phase 3 program of vadadustat for treatment of anemia in dialysis-dependent ckd: Rationale and study design Am J Kidney Dis 2017; 69(4):A102- A102. PMID: Not assigned. Abstract

Pulmonary and Critical Care Medicine

Abu Sayf A, Razvi SA, Al-Darzi W, Hegab S, and Awdish R. Pulmonary veno-occlusive disease masquerading as chronic thrombo embolic pulmonary hypertension Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Albujoq K, Awdish R, and Hegab S. The PE that never was: A rare case of combined PVOD and pulmonary vein thrombosis Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Al-Darzi W, Zlatopolsky M, Abu Sayf A, and Awdish RL. To close or not to close a patent foramen ovale: That is the question J Gen Intern Med 2017; 32(2):S624-S625. PMID: Not assigned. Abstract

Al-Darzi W, Chaaban S, Abu Sayf A, Tirgari S, and Uduman J. Gaps in osmolal gap: A case of mistaken osmolal gap in a patient with diabetic ketoacidosis American Journal of Respiratory and Critical Care Medicine 2017; 195PMID: Not assigned. Abstract

Ali M, Saleh Z, Laktineh A, and Huda N. Acute eosinophilic pneumonia in a hookah smoker Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Assar S, Nakhle A, and Lazar M. Eat your heart out: Right heart collapse from bowel obstruction Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Avasarala SK, Hejab A, and Lazar M. It is not always about lady windermere: Cavitating lung disease due to mycobacterium avium complex Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Bachert H, Bazan L, and Thavarajah K. Shrinking lung syndrome with hypercapneic respiratory failure responsive to mycophenolate mofetil and systemic steroids Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Chaaban S, and Thavarajah K. Penicillum marneffei presenting as a pneumonia and obstructive airway disease exacerbation Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Chupp G, Kline J, Khatri SB, McEvoy C, Silvestri GA, Shifren A, Bansal S, McClelland M, Dransfield M, Olivenstein R, Lawson E, Simoff M, Wahidi MM, Lamb CR, Ferguson S, Haas A, Hogarth K, Tejedor R, Toth JW, Majid A, Rafeq S, Fitzgerald JM, Enfield K, Grubb GM, McMullen E, and Laviolette M. Post-approval study for bronchial thermoplasty (BT): Results to 2 years Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Dudar A, Chaaban S, Lazar M, and Ouellette D. Juvenile rheumatoid arthritis or childhood sarcoidosis? Chest 2017; 152(4):A930. PMID: Not assigned. Abstract

Garbarino A, Miller N, and Tatem G. Successful catheter-directed thrombolysis for pulmonary embolism during pregnancy Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Gezahegne S, Morris Z, Folt D, Miller N, Garbarino A, and DiGiovine B. Predictor of exertional hypoxemia: Dlco Vs. Dlco/va. a retrospective study Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

127 Gezahegne S, Hart R, and Awdish R. The red inmate Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Gorgis S, Sen P, and Jennings J. The silent giant: A rare case of a pleural hemangiopericytoma Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Hanlon K, Stone C, and Morris Z. Follicular bronchiolitis: A rare cause of cystic lung disease Chest 2017; 152(4):A437. PMID: Not assigned. Abstract

Kawar Y, and Starosta D. Pulmonary vein thrombosis due to IVIG use in Guillain-Barre syndrome Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Kelly BA, Awdish R, and Hegab S. Good fences make good neighbors: How an iatrogenic atrial septal defect can impact the pulmonary circulation Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Mahmoud M, Awdish R, and Thavarajah K. A rare case of antisynthetase syndrome presented with cardiogenic shock as an initial presentation Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Miller N, Garbarino A, Folt D, and Jennings J. Metastatic bronchopulmonary leiomyosarcoma: A rare progression of benign disease Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Miller N, Garbarino A, and Jennings J. A case of propofol infusion syndrome in the intensive care setting Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Molina-Pallete GM, Kansagra J, and Brar I. Utilization of interferon gamma release assays (IGRAs) for the detection of latent tuberculosis infection (LTBI) at a tertiary care hospital Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Molina-Pallete GM, and Ray C. Chronic cough of unknown primary Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Nadeem O, Motwani A, Parikh S, Borgi J, and Hudson M. Acquired left ventricular outflow tract to right atrial fistula due to tricuspid valve endocarditis Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Nakhle A, Polevoy R, Ali M, Assar S, and Mesleh G. Bilateral pneumothorax due to unexpected cause J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Nebor AE, and Morris Z. Respiratory bronchiolitis associated interstitial lung disease (RBILD)/desquamative interstitial pneumonia (DIP) presenting as cystic lung disease Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Onyenekwe JC, and Awdish R. Cardiac tamponed masking as decompensated RV failure in a PH patient Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Razvi SA, Ali M, and Corrales JP. A rare presentation of post-transplant lymphoproliferative disorder as isolated splenomegaly in a lung transplant recipient Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Saeed A, Kelly B, Awdish R, and Hegab S. Natural killer cell lymphocytosis as a cause of pulmonary arterial hypertension: A case report Chest 2017; 152(4):A1015. PMID: Not assigned. Abstract

Samuel G, Baltarowich L, Albujoq K, Chaaban S, Usman M, and Ouellette D. Acetaminophen overdose in a third trimester pregnancy Chest 2017; 152(4):A379. PMID: Not assigned. Abstract

Samuel G, Diaz-Mendoza J, Paidipaty MSB, and Ray C. The fake iron tumor Chest 2017; 152(4):A721. PMID: Not assigned. Abstract

Selim R, Gorgis SA, Al-Darzi W, Abdelrahim E, and Digiovine B. A case of isolated acquired factor VIII inhibitor J Gen Intern Med 2017; 32(2):S394-S395. PMID: Not assigned. Abstract

Veljanovski J, and Ouellette DR. Risk factors for hospital admission with a respiratory illness in a comparative effectiveness cohort of patients with chronic obstructive pulmonary disease (COPD) Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

128 Yung RC, Ost D, Simoff M, Reddy C, Goyal A, Barjakarevic I, Garff M, Larson K, O'Driscoll J, and Makani S. Baseline characteristics of participants in pl-208: A multi-center trial of the prolung test (TM) (Transthoracic Bioconductance Measurement) as an adjunct to CT chest scans for the risk stratification of patients with pulmonary lesions suspicious for lung cancer Annals of Oncology 2017; 28:1. PMID: Not assigned. Abstract

Rheumatology

Coniglio B, Drake S, and Meysami A. Musculoskeletal ultrasound training for the internal medicine resident: Development and assessment of a teaching curriculum for elective rotation J Gen Intern Med 2017; 32(2):S694- S695. PMID: Not assigned. Abstract

Sheinin R, Maranda E, Rubin B, and Lim HW. Eosinophilic fasciitis associated with pyoderma gangrenosum: Report of a case and discussion J Am Acad Dermatol 2017; 76(6):AB123. PMID: Not assigned. Abstract

Sreih AG, Ezzedine R, Leng L, Fan J, Yao J, Reid D, Carette S, Cuthbertson D, Dellaripa P, Hoffman GS, Khalidi NA, Koening CL, Langford CA, McAlear CA, Maksimowicz-Mckinnon K, Monach PA, Seo P, Specks U, St Clair W, Stone J, Ytterberg SR, Edberg J, Merkel PA, and Bucala R. The role of macrophage migration inhibitory factor in the pathogenesis of granulomatosis with polyangiitis Rheumatology 2017; 56:118-119. PMID: Not assigned. Abstract

Sleep Medicine

Herring WJ, Connor KM, Snyder E, Snavely DB, Zhang Y, Hutzelmann J, Matzura-Wolfe D, Benca RM, Krystal AD, Walsh JK, Lines C, Roth T, and Michelson D. Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data Psychopharmacology 2017; 234(11):1703-1711. PMID: Not assigned. Abstract

General Internal Medicine/Palliative/Other

Abdel-Rahman Z, and Avasarala SK. Denosumab-induced hypocalcemia J Gen Intern Med 2017; 32(2):S483. PMID: Not assigned. Abstract

Abdel-Rahman Z, Alsafadi K, Jabbour H, Mendiratta V, Alkhatib Y, and Donthireddy V. Hematology referrals for mild thrombocytopenia in a tertiary center in detroit: A step towards a standardized approach for referrals and testing Blood 2017; PMID: Not assigned. Abstract

Al-Darzi W, Rahman M, Sandhu S, Philip J, and Shah V. Rare case of olanzapine induced hypoglycemia, bradycardia, and hypothermia J Gen Intern Med 2017; 32(2):S576-S577. PMID: Not assigned. Abstract

Cerasale M, Starakiewicz P, Parikh M, Stanley S, and Mohtadi O. Code blue outcomes: Relation to the modified early warning score J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Coniglio B, Drake S, and Meysami A. Musculoskeletal ultrasound training for the internal medicine resident: Development and assessment of a teaching curriculum for elective rotation J Gen Intern Med 2017; 32(2):S694- S695. PMID: Not assigned. Abstract

Garza N, Georgie F, Horbal A, Willens DE, and Haftka-George AC. Does physician gender effect ordering practice J Gen Intern Med 2017; 32(2):S169. PMID: Not assigned. Abstract

Gildeh E, and Cerasale M. Rhabdomyolysis and pancytopenia secondary to an unexpected interaction between ledipasvir/sofosbuvir, atorvastatin and colchicine J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Gunderson H, Cerasale M, Jeffries II J, Akhras E, Bazzi K, Lingam C, Watson P, and Luyeho P. Putting the shm key principles into practice: Direct objective clinical evaluation of new-hire hospitalists to improve physician communication and engagement while fulfilling fppe J Hosp Med 2017; 12(s2)PMID: Not assigned. Abstract

Joshi S, Cerasale M, Heidemann D, Yarlagadda J, Rana S, and Jeffries II J. Is the New Orleans criteria for head ct useful for inpatient falls? J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

129 Kupsky D, Dee Wang D, Eng M, Gheewala N, Nakhle A, Georgie F, Shah R, Mahan M, Greenbaum A, and O'Neill W. Socioeconomic disparities in access for Watchman device insertion in patients with atrial fibrillation and at elevated risk of bleeding J Am Coll Cardiol 2017; 70(18):B177. PMID: Not assigned. Abstract

Malik D, Kuriakose P, Philip J, Hejab A, Horbal A, and Mendiratta V. Evaluating the clinical utility of testing for autoimmune disorders in the setting of leukopenia/neutropenia in an ambulatory hematology clinic Blood 2017; PMID: Not assigned. Abstract

Mawri S, Ali M, Elsheikh A, Abuzaanona A, Patel R, Koenig G, Zaidan M, Khandelwal A, Voeltz M, Kim H, O'Neill W, and Alaswad K. Comparison of an innovative hybrid closure technique versus conventional vascular closure strategy in large bore access during mechanical hemodynamic support for high risk percutaneous coronary intervention J Am Coll Cardiol 2017; 70(18):B98-B99. PMID: Not assigned. Abstract

Robbins-Ong M, Chasteen KA, and Cerasale MT. Palliative medicine consultation triggers on the general practice unit J Gen Intern Med 2017; 32(2):S780-S781. PMID: Not assigned. Abstract

Saeed A, Kelly B, Awdish R, and Hegab S. Natural killer cell lymphocytosis as a cause of pulmonary arterial hypertension: A case report Chest 2017; 152(4):A1015. PMID: Not assigned. Abstract

Samuel G, Baltarowich L, Albujoq K, Chaaban S, Usman M, and Ouellette D. Acetaminophen overdose in a third trimester pregnancy Chest 2017; 152(4):A379. PMID: Not assigned. Abstract

Samuel G, Diaz-Mendoza J, Paidipaty MSB, and Ray C. The fake iron tumor Chest 2017; 152(4):A721. PMID: Not assigned. Abstract

Schaefer JK, Souphis NM, Sood SL, Haymart B, Gu X, Kline-Rogers E, Almany SL, Kozlowski JH, Krol GD, Kaatz S, Froehlich JB, and Barnes GD. The impact of adding aspirin to warfarin without an apparent indication: An exploration of patients anticoagulated for atrial fibrillation or venous thromboembolic disease Blood 2017; 130(Suppl 1):220-220. PMID: Not assigned. Abstract

Selim R, Abdelrahim E, and Alam Z. A case of allopurinol-induced dress syndrome J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Selim R, Getzen T, and Moonka D. Outcomes of TIPS for ascites as a function of baseline renal function Hepatology 2017; 66:952A-952A. PMID: Not assigned. Abstract

Singh Z, and Gunderson H. Bacteremia: A noble source J Gen Intern Med 2017; 32(2):S454. PMID: Not assigned. Abstract

NEUROLOGY

Affan M, Kananeh M, Schultz L, Elias S, and Cerghet M. Disease course and treatment of neurosarcoidosis in a single center cohort study of 113 cases Neurology 2017; 88(16)PMID: Not assigned. Abstract

Ahmad A, Tahir R, and Mitsias P. Moyamoya vasculopathy in a patient with scleroderma: A case report and review of the literature Neurology 2017; 88(16) PMID: Not assigned. Abstract

Al Adas Z, Lin J, Nypaver T, Weaver MR, Shepard AD, Chau LC, Miller D, and Kabbani L. Natural history of progression of carotid artery stenosis J Vasc Surg 2017; 65(6):50S. PMID: Not assigned. Abstract

Al Adas Z, Miller D, Weaver M, Shepard A, Nypaver TJ, Nour K, Balraj P, and Kabbani L. Cerebrovascular injuries are commonly found in acute type b aortic dissections and are associated with blood pressure derangements and poor outcome J Vasc Surg 2017; 66(2):E28-E28. PMID: Not assigned. Abstract

Ali MM, Jayasundara S, and Ewing JR. Development and testing of nanoformulation of a vascular disrupting agent in rat glioma with MRI monitoring Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Ali M, Jayasundara S, DeCarvalho A, and Ewing J. Nanoformulation of a vascular disrupting agent for the treatment of glioma with MRI monitoring Neuro-Oncology 2017; 19:vi24-vi25. PMID: Not assigned. Abstract

130 Arcila-Londono X, Kashouty R, Ryczko S, Steijlen K, Newman D, and Walbert T. The effect of the percutaneous endoscopic gastrostomy (PEG) tube placement on the quality-of-life of ALS patients and their caregivers Amyotroph Lateral Scler Frontotemporal Degener 2017; 18:312-313. PMID: Not assigned. Abstract

Bagher-Ebadian H, Dehkordi A, and Ewing J. SU-F-I-26: Maximum likelihood and nested model selection techniques for pharmacokinetic analysis of dynamic contrast enhanced mri in patients with glioblastoma tumors Med Phys 2016; 43(6):3392. PMID: 28048158. Abstract

Bagher-Ebadian H, Mohammadian Behbahani M, and Ewing J. WE-FG-206-03: An adaptive model for pharmacokinetic nested model selection in dynamic contrast enhanced mri data analysis Med Phys 2016; 43(6):3831. PMID: 28048278. Abstract

Biondo AM, and Bowyer S. Meg localization of cortical activity during language processing utilizing mr- focuss and coherence source imaging Neurology 2017; 88(16)PMID: Not assigned. Abstract

Brady P, Kananeh M, Louchart L, Mehta C, Rehman M, Lewis A, Greer D, Mayer S, and Varelas P. Single or dual brain death exams: Tertiary hospital experience over 11.5 years Neurocritical Care 2017; 27(2):S56. PMID: Not assigned. Abstract

Calo S, Jaehne AK, Keenan KA, Xu J, Tawil B, Thompson R, Knight RA, Miller J, Lewandowski C, and Tavarekere NN. Deterioration in recombinant tissue plasminogen activator after repeated freezing and thawing cycles for thromboelastography Stroke 2017; 48PMID: Not assigned. Abstract

Cerghet M, Poisson L, Dutta I, Suhil H, Elias SB, Giri S, and Mangalam A. A blood-based, six metabolite signature for relapsing-remitting multiple sclerosis Mult Scler J 2017; 23(1):14-14. PMID: Not assigned. Abstract

Chen J, Cui C, Zacharek A, Venkat P, Yu P, and Chopp M. Neurorestorative therapy of stroke in T2DM mice with exosomes derived from brain endothelial cells Stroke 2017; 48PMID: Not assigned. Abstract

Chen Z, Yan T, Zhao Q, Shen Y, Li W, Chopp M, and Chen J. Brain-heart interaction: Age aggravates cardiac damage after cerebral ischemic stroke Stroke 2017; 48PMID: Not assigned. Abstract

Dharaiya D, Modi S, Schultz L, and Varelas P. Drug intoxication and increased mortality in anoxic brain injury Neurocrit Care 2017; 27(2):S29. PMID: Not assigned. Abstract

Girotra T, Affan M, Marin H, Schultz L, and Miller D. Factors affecting distal hyperintense vessel sign, a postulated marker for intracranial collateral circulation Neurology 2017; 88(16)PMID: Not assigned. Abstract

Girotra T, Alshammaa A, Butt R, and Malik S. “what are the odds?”: A rare clinical syndrome from a rare vascular condition caused by a commonly used medication Neurology 2017; 88(16)PMID: Not assigned. Abstract

Irshad K, Schultz L, Zahoor S, and Malik S. Moyamoya and ethnic diversity Neurology 2017; 88(16) PMID: Not assigned. Abstract

Kananeh M, Louchart L, Brady P, Mehta C, Rehman M, Lewis A, Greer D, and Varelas P. Single or dual brain death exams: Tertiary hospital experience over 11 years Neurology 2017; 88(16)PMID: Not assigned. Abstract

Kananeh M, Louchart L, Brady P, Mehta C, Rehman M, Lewis A, Greer D, and Varelas P. Consent rate for organ donation after brain death: A single center experience over 11 years Neurology 2017; 88(16)PMID: Not assigned. Abstract

Katramados AM, Marin H, Kole M, Varelas P, Miller D, Malik S, Hefzy H, Modi S, Schultz L, Marmagkiolis K, Tsitlakidou D, Affan M, and Mitsias P. Analysis of hypoplastic variants of the circle of willis in patients with first-ever lacunar stroke Stroke 2017; 48PMID: Abstract

Khan H, and Hefzy HM. A transition of care program to reduce stroke related hospital readmissions Stroke 2017; 48PMID: Not assigned. Abstract

LeWitt PA, Fernandez HH, Hauser RA, Isaacson SH, Lew M, Pahwa R, Saint-Hilaire M, Waters C, Sedkov A, and Oh C. Inhaled levodopa (CVT-301 84mg) significantly improves motor function during off periods in Parkinson's disease (PD) subjects: A phase 3 study (SPAN-PD™) Mov Disord 2017; 32(9):e1-e2. PMID: Not assigned. Abstract

131 Li R, Chopp M, Chen J, Zacharek A, Wang F, Landshoot-Ward J, and Cui X. ABCA1/HDL signaling pathway mediates white matter remodeling and improves functional outcome after stroke Stroke 2017; 48PMID: Not assigned. Abstract

Mahajan A, Bowyer S, Zillgitt A, LeWitt P, Kaminski P, and Sidiropoulos C. A multiparametric MEG study of the effect of medications on neuronal oscillations in generalized or cervical dystonia Mov Disord 2017; 32PMID: Not assigned. Abstract

Mahajan A, Bowyer S, Zillgitt A, LeWitt P, Kaminski P, and Sidiropoulos C. A pilot magnetoencephalographic study of coherence in cervical dystonia and meige syndrome Mov Disord 2017; 32(9):e2. PMID: Not assigned. Abstract

Mahajan A, Jankovic J, Marsh L, Patel A, and Patel N. Substance abuse in cervical dystonia Mov Disord 2017; 32(9):e16. PMID: Not assigned. Abstract

Maraka S, Karam A, Walbert T, and Lee I. Malignant cerebral edema associated with radiation and laser ablation for brain tumors Neurology 2017; 88(16)PMID: Not assigned. Abstract

Memon A, Madani S, Schultz L, Grover K, Arcila-Londono X, Sripathi N, and Ahmad B. Terminal latency index (TLI) and sensory electrophysiology in paraproteinemic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Neurology 2017; 88(16)PMID: Not assigned. Abstract

Memon A, Madani S, Ahmad BK, Schultz L, Grover K, Arcila-Londono X, and Sripathi N. Does electrophysiology and treatment response differ in idiopathic vs diabetic chronic inflammatory demyelinating polyneuropathy (CIDP)? J Peripher Nerv Syst 2017; 22(3):340-341. PMID: Not assigned. Abstract

Mittelstaedt D, Klahr P, Nejad-Davarani S, Schulz H, Goshen L, Morris E, and Glide-Hurst C. Sensitivity of auto- segmentation to CT reconstruction algorithms Med Phys 2017; 44(6):3302. PMID: Not assigned. Abstract

Modi S, Marin H, Varelas P, and Mitsias P. Role of pial collateral flow in acute ischemic stroke outcomes Neurology 2017; 88(16)PMID: Not assigned. Abstract

Modi S, Shah K, Affan M, Tahir R, Varelas P, and Marin H. Trends of hospitalization cost of aneurysmal subarachnoid hemorrhage in the United States Stroke 2017; 48PMID: Not assigned. Abstract

Molaeimanesh Z, A NVD, Faghihi R, Elmghirbi R, Ewing J, Wen N, I JC, and Bagher-Ebadian H. Quantitative MR estimation of interstitial fluid pressure in a pre-clinical rat model of glioblastoma tumors using an adaptive model and principle component analysis Med Phys 2017; 44(6):3018-3019. PMID: Not assigned. Abstract

Morris DC, Cheung WL, Chopp M, Zhang T, and Zhang Z. Beta-aminoisobutyric induces neurite outgrowth in primary cortical neurons Acad Emerg Med 2017; 24:S195. PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Zhang T, Lu M, and Zhang ZG. Reactive gliosis improves outcome in an aged rat model of embolic stroke Stroke 2017; 48PMID: Not assigned. Abstract

Mullen E, Ratner M, Sobotka S, Rasouli J, Chartrain A, Wheelwright D, Griffiths S, Bederson J, Gordon E, Neibart E, Mayer S, and Dangayach NS. The predictive value of inflammatory biomarkers on 30-day mortality in the neurological critical care setting Neurocrit Care 2017; 27(2):S234. PMID: Not assigned. Abstract

Nagaraja TN, Elmghirbi R, Irtenkauf S, Hasselbach L, Tawil B, Brown SL, Panda S, Cabral G, Mikkelsen T, Ewing JR, and DeCarvalho A. Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patientderived xenograft mouse models of glioblastoma Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Nejad-Davarani S, Weiss S, Sevak P, Renisch S, and Glide-Hurst C. Analysis of temporal patient-specific MR distortions:A per-organ assessment Med Phys 2017; 44(6):3137. PMID: Not assigned. Abstract Pan W, Liu X, Zhang X, Wang X, Hu J, Zhang R, Chopp M, and Zhang ZG. The microrna 17-92 cluster in neural progenitor cells is required for stroke-induced neurogenesis and gliogenesis Stroke 2017; 48PMID: Not assigned. Abstract

132 Pfeiffer RF, Quigley EMM, Factor S, Fernandez H, McDermott MP, Shannon K, Casaceli C, de Blieck EA, Sharma S, Gottesdiener K, Hylan ML, Hebert D, Drasby E, Freeman A, Goudreau J, Deik A, Lew M, Burack M, Uc E, Kurlan R, Morgan J, Malaty I, Shukla AW, Brodsky M, Elmer L, LeWitt P, Lannon M, Kawai C, Olalde H, Sieren J, Farrow B, Wilson S, Kaminski P, Russell D, and Parkinson Study G. A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned Parkinsonism Relat Disord 2017; 37:101-105. PMID: Not assigned. Abstract

Price RG, Knight RA, Hwang K, Bayram E, and Glide-Hurst C. TU-AB-BRA-05: Optimization of a novel large field of view distortion phantom for mr-only treatment planning Med Phys 2016; 43(6):3734. PMID: 28046653. Abstract

Qian JY, Chopp M, Chen N, and Liu Z. Subacute intranasal administration of tissue plasminogen activator increases corticospinal tract plasticity and functional recovery after stroke in mice Stroke 2017; 48PMID: Not assigned. Abstract

Race JN, Griffiths S, Wheelwright D, Gordon E, Bederson J, Mayer SA, and Dangayach NS. Does cognitive reserve predict 3-month functional outcome in neurocritical care? Neurocritical Care 2017; 27(2):S209. PMID: Not assigned. Abstract

Rao JU, Coman D, Walsh J, Ali M, Huang Y, and Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH J Cereb Blood Flow Metab 2017; 37:490-490. PMID: Not assigned. Abstract

Rattan R, Buekers TE, Chhina J, Uddin MH, Giri S, and Munkarah AR. Cisplatin exposure causes metabolic stress and adaptation in ovarian cancer cells Gynecol Oncol 2017; 145:110. PMID: Not assigned. Abstract

Rattan R, Dar S, Rasool N, Ali-Fehmi R, Giri S, and Munkarah AR. Depletion of immunosuppressive myeloid- derived suppressor cells impedes ovarian cancer growth Gynecol Oncol 2017; 145:213-214. PMID: Not assigned. Abstract

Rehman MF. Multidisciplinary management approach to fulminant hepatic encephalopathy in the neurocritical care unit: A single-center experience Neurocritical Care 2017; 27(2):S221. PMID: Not assigned. Abstract

Shah K, Alshammaa A, Affan M, Schultz L, and Zaman I. MyChart enrollment and other factors that affect no show rates in the neurology resident clinic Neurology 2017; 88(16)PMID: Not assigned. Abstract

Shah K, Martin K, Yousuf A, and Chandok A. Tacrolimus-associated posterior reversible encephalopathy syndrome Neurology 2017; 88(16) PMID: Not assigned. Abstract

Shah K, and Miller DJ. Eagle's syndrome: Viewing a rare disorder from a new perspective Neurology 2017; 88(16) PMID: Not assigned. Abstract

Shah K, Mayer SA, Kole MK, Marin HL, Schultz L, and Miller DJ. Does administration of intravenous contrast impact outcomes upon large vessel occlusion patients undergoing intra-arterial therapy? Interventional Neurology 2017; 6:91. PMID: Not assigned. Abstract

Sharifi H, Zhang H, Jin JY, Kong FM, Chetty IJ, and Zhong H. TU-AB-202-07: A novel method for registration of mid-treatment pet/ct images under conditions of tumor regression for patients with locally advanced lung cancers Med Phys 2016; 43(6):3738. PMID: 28047401. Abstract

Sharifi H, Glide-Hurst C, Gopal A, Brown S, Chetty IJ, Movsas B, and Zhong H. Evaluation of the physiological response to fractionated radiotherapy Med Phys 2017; 44(6):2813. PMID: Not assigned. Abstract

Sharifi H, Zhang H, Ajlouni M, Jin JY, Kong FM, Chetty IJ, and Zhong H. Investigation of heterogeneous tumor response in adaptive radiation therapy for patients with lung cancer Int J Radiat Oncol Biol Phys 2017; 99(2):E495. PMID: Not assigned. Abstract

Struck A, Osman G, Rampal N, Biswal S, Legros B, Hirsch L, Westover MB, and Gaspard N. Multistate survival analysis for seizure prediction on continuous EEG Neurology 2017; 88(16)PMID: Not assigned. Abstract

Uddin MH, Buekers TE, Elshaikh MA, Giri S, Munkarah AR, and Rattan R. Differential effects of saturated and unsaturated fatty acids on ovarian cancer growth Gynecologic Oncology 2017; 145:210. PMID: Not assigned. Abstract

133 Varelas PN, Brady P, Kananeh M, Louchart L, Mehta C, Schultz L, Abdelhak T, Mayer SA, and Rehman MF. Single versus dual brain death examination in donors does not influence the number of organs recovered or transplanted Neurocritical Care 2017; 27(2):S57. PMID: Not assigned. Abstract

Varelas PN, Kananeh M, Brady P, Louchart L, Mehta C, Mayer SA, Abdelhak T, and Frehman M. Factors that affect the approach for donation of families whose relatives became brain dead Neurocritical Care 2017; 27(2):S38. PMID: Not assigned. Abstract

Venkat P, Chopp M, Zacharek A, and Chen J. Exosomes derived from bone marrow mesenchymal stem cells of type two diabetes rats promotes neurorestoration after stroke in type two diabetic rats Stroke 2017; 48PMID: Not assigned. Abstract

Wang L, Chopp M, and Zhang ZG. PDE5 inhibitors promote recovery of peripheral neuropathy in diabetic mice Neural Regen Res 2017; 12(2):218-219. PMID: Not assigned. Abstract

Weiss S, Nejad-Davarani S, Renisch S, and Glide-Hurst C. Comparison of two methods for patient specific distortion corrections for MR only treatment planning Med Phys 2017; 44(6):3097-3098. PMID: Not assigned. Abstract

Xin H, Katakowski M, Wang F, Qian J, Santra M, Liu XS, Ali MM, Buller B, Zhang ZG, and Chopp M. Tailored multipotent mesenchymal stromal cell harvested exosomes carrying elevated miR-17-92 cluster enhance neurovascular remodeling & improve functional recovery after stroke in rats Stroke 2017; 48PMID: Not assigned. Abstract

Zhang L, Chopp M, Li C, Jiang Q, Ding GL, Zhang Y, Xiong Y, Wei M, and Zhang ZG. Exosomes derived from cerebral endothelial cells of young adult rats reduced cognitive deficits in aged diabetic rats Stroke 2017; 48PMID: Not assigned. Abstract

Zhang RL, Pan W, Zhang X, Liu X, Landschoot-Ward J, Li C, Fan B, Wang X, Chopp M, and Zhang ZG. Cerebral endothelial derived exosomes abolish cognitive impairment induced by ablation of dicer in adult neural progenitor cells Stroke 2017; 48PMID: Not assigned. Abstract

NEUROSURGERY

Ahmad A, Tahir R, and Mitsias P. Moyamoya vasculopathy in a patient with scleroderma: A case report and review of the literature Neurology 2017; 88(16) PMID: Not assigned. Abstract

Ali MM, Jayasundara S, and Ewing JR. Development and testing of nanoformulation of a vascular disrupting agent in rat glioma with MRI monitoring Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Ali M, Jayasundara S, DeCarvalho A, and Ewing J. Nanoformulation of a vascular disrupting agent for the treatment of glioma with MRI monitoring Neuro-Oncology 2017; 19:vi24-vi25. PMID: Not assigned. Abstract

Arcila-Londono X, Kashouty R, Ryczko S, Steijlen K, Newman D, and Walbert T. The effect of the percutaneous endoscopic gastrostomy (PEG) tube placement on the quality-of-life of ALS patients and their caregivers Amyotroph Lateral Scler Frontotemporal Degener 2017; 18:312-313. PMID: Not assigned. Abstract

Bier A, Bernstein P, Cazacu S, Dori A, and Brodie C. Mesenchymal stem cells and their secreted exosomes exert therapeutic effects in Duchenne muscular dystrophy J Extracell Vesicles 2017; 6:151-152. PMID: Not assigned. Abstract

Boyce-Fappiano D, Elibe E, Siddiqui MSU, Lee I, Rock J, and Siddiqui F. Incidence of local and marginal treatment failure following postoperative single fraction spine stereotactic radiosurgery Int J Radiat Oncol Biol Phys 2017; 99(2):E517. PMID: Not assigned. Abstract

Brodie S, Cazacu S, Poisson L, Kalkanis S, Ginsburg D, and Brodie C. The novel long non-coding RNA TALNEC2 regulates the stemness and mesenchymal transformation of glioma stem cells and their exosomemediated interaction with microglia cells J Extracell Vesicles 2017; 6:7. PMID: Not assigned. Abstract

134 Calo S, Jaehne AK, Keenan KA, Xu J, Tawil B, Thompson R, Knight RA, Miller J, Lewandowski C, and Tavarekere NN. Deterioration in recombinant tissue plasminogen activator after repeated freezing and thawing cycles for thromboelastography Stroke 2017; 48PMID: Not assigned. Abstract

Cloughesy T, Landolfi J, Vogelbaum M, Ostertag D, Elder B, Carter B, Chen C, Kalkanis S, Lai A, Mikkelsen T, Nghiemphu P, Piccioni D, Accomando W, Diago O, Hogan D, Jolly D, Wood K, Yang L, Gruber H, Das A, and Walbert T. Durable responses observed in idh1 wildtype and mutant recurrent high grade glioma (RHGG) with Toca 511 & Toca FC treatment Neuro-Oncology 2017; 19:vi26. PMID: Not assigned. Abstract

DeCarvalho AC, Kim H, Poisson L, Koeman J, Mikkelsen T, and Verhaak R. Discordant inheritance of chromosomal and extrachromosomal DNA elements contribute to dynamic disease evolution in glioblastoma Neuro- Oncology 2017; 19:vi97. PMID: Not assigned. Abstract

Elibe E, Boyce-Fappiano D, Siddiqui S, Lee I, Rock J, and Siddiqui F. Stereotactic radiosurgery for malignant intradural and intramedullary tumors of the spine Int J Radiat Oncol Biol Phys 2017; 99(2):E512-E513. PMID: Not assigned. Abstract

Elibe E, Boyce-Fappiano D, Siddiqui S, Lee I, Rock J, and Siddiqui F. Repeat courses of spine stereotactic radiosurgey (SRS): Efficacy and toxicity Int J Radiat Oncol Biol Phys 2017; 99(2):E518-E519. PMID: Not assigned. Abstract

Elisevich K, Mahmoudi F, Bagher-Ebadian H, Nazem-Zadeh MR, Schwalb J, Kaur M, and Soltanian-Zadeh H. Data miningmrimage features of select structures for lateralization of mesial temporal lobe epilepsy Epilepsia 2017; 58:S67-S67. PMID: Not assigned. Abstract

Jimenez-Shahed J, Bressman S, Burack M, Farace E, McInerney J, Kirk J, Saunders-Pullman R, Schwalb J, Shih L, Spindler M, Moro E, and York M. RAD-PD: Registry for the advancement of DBS in Parkinson's disease Mov Disord 2017; 32(9):e14. PMID: Not assigned. Abstract

Jolly DJ, Aghi M, Vogelbaum MA, Kalkanis SN, Bota D, Chen CC, Carter B, Elder B, Engh J, Goldlust SA, Kaptain GJ, Kesari S, Landolfi J, Liau LM, Mikkelsen T, Piccioni D, Portnow J, Singer S, Walbert T, Gruber H, Ibanez C, Mitchell L, Ostertag D, Shorr JS, Yang LQ, Das A, and Cloughesy TF. Long-term follow-up data from 126 patients with recurrent high grade glioma from three phase 1 trials of toca 511 and toca fc: Update and justification for a phase 2/3 trial Mol Ther 2017; 25(5):24-25. PMID: Not assigned. Abstract

Kandagatla P, MacKi M, Hodari-Gupta A, and Rubinfeld I. Unplanned return to the operating room in the neurosurgical population: What drives this dreaded event? J Am Coll Surg 2017; 225(4):S143. PMID: Not assigned. Abstract

Katramados AM, Marin H, Kole M, Varelas P, Miller D, Malik S, Hefzy H, Modi S, Schultz L, Marmagkiolis K, Tsitlakidou D, Affan M, and Mitsias P. Analysis of hypoplastic variants of the circle of willis in patients with first-ever lacunar stroke Stroke 2017; 48PMID: Abstract

Lassman AB, van den Bent M, Gan HK, Reardon DA, Kumthekar P, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Bain E, Holen K, and Merrell R. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, with temozolomide (TMZ) in recurrent glioblastoma (rGBM) Ann Oncol 2016; 27:1. PMID: Not assigned. Abstract

Lassman AB, Van Den Bent MJ, Gan HK, Reardon DA, Kumthekar P, Butowski NA, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Gomez EJ, Lee HJ, Roberts-Rapp L, Xiong H, Bain EE, Maag D, and Merrell RT. Efficacy analysis of ABT-414 with or without temozolomide (TMZ) in patients (pts) with EGFR-amplified, recurrent glioblastoma (rGBM) from a multicenter, international phase I clinical trial J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Malta T, Sokolov A, Gentles AJ, Burzykowski T, Gevaert O, Laird PW, Noushmehr H, and Wiznerowicz M. Molecular hallmarks of cancer: Stemness Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Malta T, Snyder J, Kalkanis S, Castro AV, and Noushmehr H. PD-l1 expression associated with glioma molecular subtypes: Clinical implications Neuro-Oncology 2017; 19:vi126. PMID: Not assigned. Abstract

Maraka S, Karam A, Walbert T, and Lee I. Malignant cerebral edema associated with radiation and laser ablation for brain tumors Neurology 2017; 88(16)PMID: Not assigned. Abstract

135 Modi S, Shah K, Affan M, Tahir R, Varelas P, and Marin H. Trends of hospitalization cost of aneurysmal subarachnoid hemorrhage in the United States Stroke 2017; 48PMID: Not assigned. Abstract

Mosella M, Sarraf T, Malta T, Chedraoui T, Noushmehr H, and Castro AV. Epigenomic glioma subtype evaluation across 31 tumor types Neuro-Oncology 2017; 19:vi103-vi104. PMID: Not assigned. Abstract

Nagaraja TN, Elmghirbi R, Irtenkauf S, Hasselbach L, Tawil B, Brown SL, Panda S, Cabral G, Mikkelsen T, Ewing JR, and DeCarvalho A. Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patientderived xenograft mouse models of glioblastoma Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Noh T, Felicella M, Poisson L, Zakaria HM, DeCarvalho A, Broadbent B, Auner G, and Kalkanis S. Raman laser damage threshold of rat pial cortex Neuro-Oncology 2017; 19:vi239. PMID: Not assigned. Abstract

Ostertag D, Accomando W, Hogan D, Diago O, Gammon D, Haghighi A, Mitchell L, Rodriguez-Aquirre M, Cloughesy T, Kalkanis S, Mikkelsen T, Landolfi J, Chen C, Vogelbaum M, Gruber H, Das A, and Jolly D. Immunological activation in responding patients with recurrent HGG after treatment with toca 511 & toca FC: Results from a phase 1 trial Neuro-Oncology 2017; 19:vi31-vi32. PMID: Not assigned. Abstract

Reardon D, Nabors B, Kumthekar P, Badruddoja M, Fink K, Lieberman F, Hu J, Dunbar E, Walbert T, Schiff D, Sherman J, Tran D, Ashby LS, Butowski N, Iwamoto F, Moertel C, Schulder M, Chen J, Bullington J, Shemesh S, Brooks C, Goswami T, and Peereboom DM. Phase 2 trial of SL-701, a novel immunotherapy comprised of synthetic short peptides against GBM targets IL-13ra2, EPHA2, and survivin, in adults with second-line recurrent GBM Neuro- Oncology 2017; 19:vi28. PMID: Not assigned. Abstract

Sabedot TS, Poisson L, DeCarvalho AC, and Noushmehr H. Depletion of 5-hydroxymethylcytosine in aggressive G-CIMP subtype Neuro-Oncology 2017; 19:vi105. PMID: Not assigned. Abstract

Shah K, Mayer SA, Kole MK, Marin HL, Schultz L, and Miller DJ. Does administration of intravenous contrast impact outcomes upon large vessel occlusion patients undergoing intra-arterial therapy? Interventional Neurology 2017; 6:91. PMID: Not assigned. Abstract

Souza C, and Noushmehr H. Predictive signature of malignant recurrence in G-CIMP tumors Neuro-Oncology 2017; 19:vi98. PMID: Not assigned. Abstract

Walbert T, Bota D, Vogelbaum M, Kalkanis S, Liau L, Mikkelsen T, Gruber H, Shorr J, Rodriguez-Aguirre M, Ostertag D, Mitchell L, Jolly D, and Cloughesy T. Quantifiable levels of the transgene, cytosine deaminase, in tumor samples following intravenous delivery of toca 511 in patients with recurrent high grade glioma Neuro-Oncology 2017; 19:265-266. PMID: Not assigned. Abstract

Walbert T, Bota D, Vogelbaum M, Kalkanis S, Liau L, Mikkelsen T, Gruber H, Shorr J, Rodriguez-Aquirre M, Ostertag D, Mitchell L, Jolly D, and Cloughesy T. Intravenous delivery of toca 511 in patients with high grade glioma results in quantifiable expression of cytosine deaminase in tumor tissue Neuro-Oncology 2017; 19:vi30-vi31. PMID: Not assigned. Abstract

Wang QH, Hu BL, Hu X, Squatrito M, Scarpace L, Decarvalho AC, Lyu S, Li PP, Li Y, Barthel FP, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng SY, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz K, Wang GC, Eskilsson E, Hu J, Mikkelsen T, Depinho R, Muller F, Heimberger A, Sulman E, Nam DH, and Verhaak R. Deciphering glioma intrinsic transcriptional subtypes identifies tumor evolution associates with changes in immune-microenvironment Neuro-Oncology 2017; 19:247-248. PMID: Not assigned. Abstract

Yeni YN, Lindquist M, Oravec D, Baumer T, Bey MJ, Bartol S, and Chang V. Cervical nerve root to foraminal size ratio correlates with post-surgical patient-reported outcomes J Orthop Res 2017; 35PMID: Not assigned. Abstract

Zhang L, Chopp M, Li C, Jiang Q, Ding GL, Zhang Y, Xiong Y, Wei M, and Zhang ZG. Exosomes derived from cerebral endothelial cells of young adult rats reduced cognitive deficits in aged diabetic rats Stroke 2017; 48PMID: Not assigned. Abstract

136 OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SCIENCES

Abdulfatah E, Ghanim MT, Chaib O, Daaboul M, Alosh B, Al-Obaidy KI, Mahdi Z, Hayek K, Sakr S, Munkarah AR, Bandyopadhyay S, and Ali-Fehmi R. Ovarian granulosa cell tumors: A surveillance, epidemiology and end results (seer) data review of prognostic clinicopathological parameters in 1815 patients Lab Invest 2017; 97:271A-271A. PMID: Not assigned. Abstract

Abdulfatah E, Sakr S, Morris RT, Munkarah AR, Barbuto D, Euscher E, Frauenhoffer E, Montiel D, Malpica A, Silva EG, and Ali-Fehmi R. Mucinous differentiation is predictive of improved outcomes in low- grade endometrioid carcinoma Gynecol Oncol 2017; 145:121-122. PMID: Not assigned. Abstract

Al-Mallah MH, Ahmed A, Qureshi W, Elshawi R, Brawner C, Blaha M, Ahmed H, Ehrman J, Keteyian S, and Sakr S. Using machine learning to define the association between cardiorespiratory fitness and all-cause mortality: The fit (henry ford exercise testing) project J Am Coll Cardiol 2017; 69(11):1612-1612. PMID: Not assigned. Abstract

Bossick A, Wegienka G, and Sangha R. Association between patient depression level and hysterectomy satisfaction J Minim Invasive Gynecol 2017; 24(7):S84. PMID: Not assigned. Abstract Eisenstein DI, and Zwain OA. Robotic repair of uterine defect associated with extra uterine menstruation Journal of Minimally Invasive Gynecology 2017; 24(7):S127. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Wang Y, Jamil M, Matthews A, Yousif M, Richardson D, Atiemo HO, and Luck A. Longterm follow up in patients with mid-urethral slings with BMI greater than 40 Neurourol Urodyn 2017; 36:S147. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Matthews A, Quinn T, Jesse M, Atiemo HO, and Richardson D. Correlation between michigan incontinence severity index and american urolgical society symptom index in female incontinence patients Neurourol Urodyn 2017; 36:S86. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Quinn T, Matthews A, Jesse M, Atiemo HO, and Richardson D. Preliminary exploration: Can suffering and acceptance be found in the discordance between measures? Neurourol Urodyn 2017; 36:S87. PMID: Not assigned. Abstract

ElShatanoufy S, Wang Y, Matthews A, Jamil ML, Yousif M, Gutta S, Gill H, and Luck A. Effect of morbid obesity on mid-urethral sling effecacy for the management of stress urinary incontinence Female Pelvic Med Reconstr Surg 2017; 23(5):S41. PMID: Not assigned. Abstract

Ghanem AI, Modh A, Burmeister C, Buekers T, and Elshaikh MA. Does interval between hysterectomy and start of radiation treatment influence survival in early stage endometrial carcinoma? a national cancer database analysis Int J Radiat Oncol Biol Phys 2017; 99(2):E292. PMID: Not assigned. Abstract

Hijaz M, Rasool N, Munkarah AR, and Rattan R. Weighing your risks: Obesity and ovarian cancer Gynecol Oncol 2017; 145:202. PMID: Not assigned. Abstract

Hijaz M, Walton EM, Tsafrir Z, Aoun J, and Eisenstein D. Essure and pelvic pain: Risk factors for device removal and reintervention Obstet Gynecol 2017; 129:65S-66S. PMID: Not assigned. Abstract

Jaber S, Buekers TE, Hanna RK, Munkarah AR, and Rasool N. Suboptimal primary debulking vs neoadjuvant chemotherapy followed by interval debulking: Where does the balance tilt? Gynecol Oncol 2017; 145:129-130. PMID: Not assigned. Abstract

Modh A, Ghanem AI, Burmeister C, Hanna RK, and Elshaikh MA. What is the optimal adjuvant treatment sequence for node-positive endometrial cancer? Int J Radiat Oncol Biol Phys 2017; 99(2):E303-E304. PMID: Not assigned. Abstract

Paquet A, and Keerthy M. Outcome comparison before & after new protocol of dvt chemoprophylaxis for cesarean section patients Obstet Gynecol 2017; 129:124S-125S. PMID: Not assigned. Abstract

Petersen S, Khangura R, Fitzgerald M, Sousa D, and Goyert G. Risk of cesarean with obesity and advancing maternal age Obstet Gynecol 2017; 129:31S. PMID: Not assigned. Abstract

Pucheril DT, Elshatanoufy S, Irish V, Diaz M, and Atiemo HO. Does ureaplasma urealyticum have an active role in female lower urinary tract symptoms? Neurourol Urodyn 2017; 36:S63-S64. PMID: Not assigned. Abstract

137

Qu MX, Velker V, Leung E, Kwon J, Elshaikh MA, Kong I, Logie N, Mendez LC, Van Der Putten L, Donovan E, Munkarah AR, Wiebe EM, Louie AV, and D'Souza DP. The role of adjuvant therapy in stage IA serous and clear cell uterine cancer: A pooled analysis Radiother Oncol 2017; 123:S292. PMID: Not assigned. Abstract

Qu MX, Velker V, Leung EW, Kwon J, Elshaikh MA, Kong I, Logie N, Mendez LC, Van Der Putten L, Donovan E, Munkarah AR, Wiebe EM, Louie AV, and D'Souza DP. Improved disease control with adjuvant therapy for stage IA serous and clear cell uterine cancer: A pooled multi-institutional analysis Int J Radiat Oncol Biol Phys 2017; 99(2):S229. PMID: Not assigned. Abstract

Rattan R, Buekers TE, Chhina J, Uddin MH, Giri S, and Munkarah AR. Cisplatin exposure causes metabolic stress and adaptation in ovarian cancer cells Gynecol Oncol 2017; 145:110. PMID: Not assigned. Abstract

Rattan R, Dar S, Rasool N, Ali-Fehmi R, Giri S, and Munkarah AR. Depletion of immunosuppressive myeloid- derived suppressor cells impedes ovarian cancer growth Gynecol Oncol 2017; 145:213-214. PMID: Not assigned. Abstract

Saeed H, Rubinfeld I, and Sangha R. Vaginal hysterectomy outcomes; Complications and analysis of risk factors for 30-day readmission J Minim Invasive Gynecol 2017; 24(7):S74-S75. PMID: Not assigned. Abstract

Sakr S, Al-Wahab Z, Abdulfatah E, Rosen BP, Morris RT, Munkarah AR, and Ali-Fehmi R. Granulosa cell tumors: A SEER data review of prognostic parameters in 1815 patients Gynecol Oncol 2017; 145:127. PMID: Not assigned. Abstract

Sangha R, and Keerthy M. Blood transfusion trends in women with abnormal uterine bleeding Obstet Gynecol 2017; 129:45S. PMID: Not assigned. Abstract

Sangha R, Saeed H, Bossick A, and Wegeinka G. Do women express regret after hysterectomy? J Minim Invasive Gynecol 2017; 24(7):S38-S39. PMID: Not assigned. Abstract

Sangha R, Saeed H, and Rubinfeld I. Analysis of risk factors for readmission after hysterectomy: Use of a national database J Minim Invasive Gynecol 2017; 24(7):S76. PMID: Not assigned. Abstract

Sousa D, Matthews A, Yousif M, Jesse M, Elshatanoufy S, and Richardson D. Divergent perceptions of gender interactions in a medical teaching environment Obstet Gynecol 2017; 130:46S-46S. PMID: Not assigned. Abstract

Uddin MH, Buekers TE, Elshaikh MA, Giri S, Munkarah AR, and Rattan R. Differential effects of saturated and unsaturated fatty acids on ovarian cancer growth Gynecologic Oncology 2017; 145:210. PMID: Not assigned. Abstract

Underwood J, Stark A, Swain M, Newman L, and Petersen S. Will delaying mammography screening to age 50 worsen breast cancer disparities among African American women? Gynecol Oncol 2017; 145:142. PMID: Not assigned. Abstract

Underwood J, Saeed H, Chae EY, and Hanna RK. Nonspecific tumor markers in the era of value based medicine: Role of CA 19-9 in the pelvic mass workup J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Zwain O, and Eisenstein D. Laparoscopic myomectomy of infarcted leiomyoma with cutaneous fistula J Minimally Invasive Gynecol 2017; 24(7):S139. PMID: Not assigned. Abstract

Urogynecology

Elshatanoufy S, Griffin M, Wang Y, Jamil M, Matthews A, Yousif M, Richardson D, Atiemo HO, and Luck A. Longterm follow up in patients with mid-urethral slings with BMI greater than 40 Neurourol Urodyn 2017; 36:S147. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Matthews A, Quinn T, Jesse M, Atiemo HO, and Richardson D. Correlation between michigan incontinence severity index and american urolgical society symptom index in female incontinence patients Neurourol Urodyn 2017; 36:S86. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Quinn T, Matthews A, Jesse M, Atiemo HO, and Richardson D. Preliminary exploration: Can suffering and acceptance be found in the discordance between measures? Neurourol Urodyn 2017; 36:S87. PMID: Not assigned. Abstract

138

OPTHALMOLOGY

Mi X, Yao Y, Liu Q, Kumar A, Gao H, Zhou L, and Mi QS. HDAC3 controls homeostasis of retina-resident microglia derived from embryonic precursors J Immunol 2017; 198(1) PMID: Not assigned. Abstract

ORTHOPAEDICS, BONE & JOINT AND ATHLETIC MEDICINE

Al-Mallah MH, Ahmed A, Qureshi W, Elshawi R, Brawner C, Blaha M, Ahmed H, Ehrman J, Keteyian S, and Sakr S. Using machine learning to define the association between cardiorespiratory fitness and all-cause mortality: The fit (henry ford exercise testing) project J Am Coll Cardiol 2017; 69(11):1612-1612. PMID: Not assigned. Abstract

Baumer TG, Dischler J, Mende V, Zauel R, Van Holsbeeck M, Siegal DS, Moutzouros V, and Bey MJ. Influence of asymptomatic rotator cuff pathology on in-vivo shoulder motion and clinical outcomes J Orthop Res 2017; 35PMID: Not assigned. Abstract

Fitzgerald J, Endicott J, and Holden P. Protein expression, glycosylation and assembly of the alpha 6 chain, a new member of the collagen VI family J Orthop Res 2017; 35PMID: Not assigned. Abstract

Frisch NB, Evans TJ, Dobson C, Wang Y, Levin AM, Gibson G, Mott MP, and Parsons TW. Validation of a rat model for analyzing microRNA in CHONDROSARCOMA J Orthop Res 2017; 35PMID: Not assigned. Abstract

Gardinier JD, Al-Omaishi S, Morris MD, and Kohn DH. Osteocytes' response to PTH(1-34) regulates perilacunar tissue composition J Orthop Res 2017; 35PMID: Not assigned. Abstract

Herfat S, Roach NT, Rainbow M, Baumer T, Bey MJ, Marmor M, Feeley B, and Young NM. Anatomical shape of the shoulder as a predictor of rotator cuff injury J Orthop Res 2017; 35PMID: Not assigned. Abstract

Okoroha KR, Marfo K, Meta F, Matar R, Shehab R, Thompson T, Moutzouros V, and Makhni EC. Amount of minutes played does not contribute to anterior cruciate ligament injury in national basketball association athletes Orthopedics 2017; 40(4):e658-e662. PMID: Not assigned. Abstract

Oravec DJ, Flynn MJ, and Yeni YN. The relationship of whole human vertebral body creep to geometric, microstructural and material properties J Orthop Res 2017; 35PMID: Not assigned. Abstract

Oravec DJ, Kim W, Flynn MJ, and Yeni YN. Whole human vertebral body creep is associated with DTS- derived texture parameters J Orthop Res 2017; 35PMID: Not assigned. Abstract

Qureshi W, Ahmed A, Blaha M, Brawner C, Ehrman J, Kupsky D, Keteyian S, Ahmed H, and Al-Mallah M. Chronotropic incompetence and long-term risk of heart failure: The henry ford exercise testing project J Am Coll Cardiol 2017; 69(11):691-691. PMID: Not assigned. Abstract

Rostami N, Kohn DH, and Gardinier JD. PTH(1-34) reduces microdamage in the mouse femur under fatigue loading J Orthop Res 2017; 35PMID: Not assigned. Abstract

Yeni YN, Dix MR, Xiao A, Oravec DJ, and Flynn MJ. Vertebral endplate and shell thickness measurement using digital tomosynthesis J Orthop Res 2017; 35PMID: Not assigned. Abstract

Yeni YN, Lindquist M, Oravec D, Baumer T, Bey MJ, Bartol S, and Chang V. Cervical nerve root to foraminal size ratio correlates with post-surgical patient-reported outcomes J Orthop Res 2017; 35PMID: Not assigned. Abstract

Young NM, Roach NT, Herfat S, Rainbow M, Marmor M, Feeley B, Baum T, and Bey M. Anatomical determinants of dysfunction inform the evolution of the human shoulder Am J Phys Anthropol 2017; 162:418. PMID: Not assigned. Abstract

139 OTOLARYNGOLOGY – HEAD AND NECK SURGERY

Chen KM, Stephen JK, Datta I, Chitale D, Divine G, and Worsham MJ. MicroRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer identify progression markers specific for estrogen receptor status Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Ghanem AI, Mannari A, Schymick MA, Burmeister C, Ghanem T, Chang S, and Siddiqui F. The effect of treatment package time in head and neck cancer patients treated with adjuvant radiation therapy and concurrent systemic therapy Int J Radiat Oncol Biol Phys 2017; 99(2):E204. PMID: Not assigned. Abstract

Lupak O, Bazydlo M, Siddiqui F, Chang S, Coniglio B, and Wang D. Timing of percutaneous endoscopic gastrostomy (PEG) tube placement as supportive care in HNSCC patients (Pts) receiving concurrent chemoradiotherapy (CRT) J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Stephen JK, Mei Chen K, Merritt J, Datta I, Chitale D, Divine G, and Worsham MJ. Methylome differences in differentiated thyroid cancers and benign Adenomas Cancer Res 2017; 77(13) PMID: Not assigned. Abstract

Umar B, Chang S, Ghanem T, Siddiqui F, Jacobsen G, Isrow D, and Keller CE. Does the extent of extracapsular spread in lymph node metastases correlate with outcomes in oropharyngeal squamous cell carcinoma? - a retrospective study Lab Invest 2017; 97:334A-334A. PMID: Not assigned. Abstract

Williams A, Ghanem T, Siddiqui F, and Chang S. Clinical assessment of cognitive function in head and neck cancer Psycho-Oncology 2017; 26:74-74. PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Network integration of epigenomic data: Leveraging the concept of master regulators in ER negative breast cancer Cancer Research 2017; 77:1. PMID: Not assigned. Abstract

PATHOLOGY

Abdel-Rahman Z, Ali H, Favazza L, and Chitale D. Poor concordance between 21-gene expression assay recurrence score and all Magee equation recurrence scores in a consecutive cohort of patients treated for hormone receptor positive early breast cancer Breast 2017; 32:S87-S87. PMID: Not assigned. Abstract

Abou Shaar R, Eby CS, and Otrock ZK. Serum ferritin trends are associated with survival in adult hemophagocytic lymphohistiocytosis Blood 2017; 130(Suppl 1):2272-2272. PMID: Not assigned. Abstract

Chen KM, Stephen JK, Datta I, Chitale D, Divine G, and Worsham MJ. MicroRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer identify progression markers specific for estrogen receptor status Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Fuller M, Gardner JM, Crane GM, Williamson SR, Chiosea S, Arnold CA, Arnold MA, Wasco MJ, and Jiang XYS. #pathjc: The founding and success of the first twitter pathology journal club Lab Invest 2017; 97:140A-140A. PMID: Not assigned. Abstract

Gadde R, and Chitale D. "Is estrogen receptor positive (er plus ) progesterone receptor negative (pr-) invasive lobular carcinoma a distinct clinicopathologic subset?" Lab Invest 2017; 97:41A-42A. PMID: Not assigned. Abstract

Gadde R, and Chitale D. Mammary and extra-mammary paget's disease-an institutional experience Lab Invest 2017; 97:41A-41A. PMID: Not assigned. Abstract

Gulati R, Carey JL, Chitale D, and Sharma G. An effective and multidisciplinary utilization framework for esoteric/referred tests in molecular pathology Lab Invest 2017; 97:507A-507A. PMID: Not assigned. Abstract

Hanlon K, Stone C, and Morris Z. Follicular bronchiolitis: A rare cause of cystic lung disease Chest 2017; 152(4):A437. PMID: Not assigned. Abstract

Jamal M, Brown R, Inamdar KV, Gomez-Gelvez J, Carey JL, and Menon MP. Evaluation of flow cytometric variables in mycosis fungoides blood staging Lab Invest 2017; 97:356A-356A. PMID: Not assigned. Abstract

140 Jebastin JAS, Gupta NS, Carskadon S, Palanisamy N, and Williamson SR. Pseudosarcomatous myofibroblastic proliferations of the urinary bladder lack the usp6 gene rearrangement common in nodular fasciitis Lab Invest 2017; 97:233A-233A. PMID: Not assinged. Abstract

Jebastin J, Tibbetts R, Pritt BS, Boxwalla A, and Samuel L. Chronic obstructive pulmonary disease exacerbation that worsened with standard treatment Clin Infect Dis 2017; 64(12):1798-1800. PMID: Not assigned. Abstract

Kouba E, Simper NB, Chen S, Williamson SR, Grignon DJ, Eble JN, MacLennan GT, Montironi R, Lopez-Beltran A, Osunkoya AO, Zhang S, Wang M, Wang L, Tran T, Emerson RE, Baldrige LA, Monn MF, Linos K, and Cheng L. Solitary fibrous tumour of the genitourinary tract: A clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene J Clin Path 2017; 70(6):508-514. PMID: Not assigned. Abstract

Lopez Plaza I, Eisenbrey A, Raoufi M, Yoshida A, and Moonka D. Treating refractory liver allograft rejection with photopheresis Am J Transplant 2017; 17:784. PMID: Not assigned. Abstract

Lopez-Plaza I. Adjunctive plasmapheresis for management of myeloma cast nephropathy-a case series J Clin Apher 2017; 32(2):113. PMID: Not assigned. Abstract

Lu ZC, Gupta NS, and Chitale D. Clinicopathologic characteristics and survival outcomes of small size breast carcinoma with metastasis Lab Invest 2017; 97:57A-58A. PMID: Not assigned. Abstract

Lu ZC, Noyes L, Cole G, Schultz D, Gaba, A, and Zhang ZY. Cytologic study of atypical squamous cells of unknown significance (ascus) on thinprep liquid based cytology and relationship to high risk hpv (hrhpv) status Lab Invest 2017; 97:106A-107A. PMID: Not assigned. Abstract

Navas J, Lopez-Plaza I, Nakai K, Isley M, Ghatol D, Brightman D, Parrott S, and Galusca D. Road to zero blood waste: Improving intraoperative blood utilization through a multidisciplinary collaborative Anesth Analg 2017; 125(3):24-25. PMID: Not assigned. Abstract

Noh T, Felicella M, Poisson L, Zakaria HM, DeCarvalho A, Broadbent B, Auner G, and Kalkanis S. Raman laser damage threshold of rat pial cortex Neuro-Oncology 2017; 19:vi239. PMID: Not assigned. Abstract

Prashar R, Shah A, Stewart D, Williamson S, and Patel A. Bk polyoma virus and malignancy: Cause or co- incidence? Am J Transplant 2017; 17:483. PMID: Not assigned. Abstract

Putchakayala K, Skorupski S, Farhan S, Chaffins M, Ilias S, Pahari H, Collins K, Nagai S, and Abouljoud M. Graft-versus-host disease following deceased donor liver transplant Am J Transplant 2017; 17:783-784. PMID: Not assigned. Abstract

Safwan M, Rizzari M, Collins K, Yoshida A, Skorupski S, Fagoaga O, Abouljoud M, and Nagai S. Effect of preformed donor-specific antibodies in intestine/ multivisceral transplantation Am J Transplant 2017; 17:369. PMID: Not assigned. Abstract

Shah AB, Gupta NS, and Williamson SR. Variant histologies are common in urinary tract cancers with positive polyomavirus (sv40) antigen immunohistochemistry Lab Invest 2017; 97:258A-259A. PMID: Not assigned. Abstract

Stephen JK, Mei Chen K, Merritt J, Datta I, Chitale D, Divine G, and Worsham MJ. Methylome differences in differentiated thyroid cancers and benign Adenomas Cancer Res 2017; 77(13) PMID: Not assigned. Abstract

Tashakori M, Sanchez J, Michalowski SM, Louissaint A, Inamdar KV, Gomez-Gelvez J, Carey JL, and Menon MP. Follicular lymphoma transforming to double and triple hit lymphoma; a clinicopathologic, morphologic and cytogenetic analysis Lab Invest 2017; 97:380A-381A. PMID: Not assigned. Abstract

Trpkov K, Athanazio D, Magi-Galluzzi C, Yilmaz H, Clouston D, Agaimy A, Williamson SR, Brimo F, Lopez JI, Ulamec M, Rioux-Leclercq N, Kassem M, Gupta NS, Al Bashir S, Hartmann A, Yilmaz A, and Hes O. Biphasic papillary renal cell carcinoma is a rare and distinct morphologic variant - clinicopathologic study of 24 novel cases Lab Invest 2017; 97:266A-266A. PMID: Not assigned. Abstract

Umar B, Chang S, Ghanem T, Siddiqui F, Jacobsen G, Isrow D, and Keller CE. Does the extent of extracapsular spread in lymph node metastases correlate with outcomes in oropharyngeal squamous cell carcinoma? - a retrospective study Lab Invest 2017; 97:334A-334A. PMID: Not assigned. Abstract

141 Underwood J, Stark A, Swain M, Newman L, and Petersen S. Will delaying mammography screening to age 50 worsen breast cancer disparities among African American women? Gynecol Oncol 2017; 145:142. PMID: Not assigned. Abstract

Varney RC, and Zarbo R. Leaning out the clinical trials process: Optimizing the last hope in cancer care Lab Invest 2017; 97:521A-521A. PMID: Not assigned. Abstract

Williamson SR, Cheng L, Gadde R, Wasco MJ, Gupta NS, Jorda M, and Kryvenko ON. Renal cell tumors with an entrapped papillary component: Evidence for a tumor-in-tumor collision phenomenon Lab Invest 2017; 97:267A- 267A. PMID: Not assigned. Abstract

Williamson SR, and Palanisamy N. Monosomy 8 as a Surrogate for TCEB1 Mutation in Renal Cell Tumors with Prominent Stroma Lab Invest 2017; 97:267A-268A. PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Network integration of epigenomic data: Leveraging the concept of master regulators in ER negative breast cancer Cancer Research 2017; 77:1. PMID: Not assigned. Abstract

PHARMACY

Al-Darzi W, Chaaban S, Abu Sayf A, Tirgari S, and Uduman J. Gaps in osmolal gap: A case of mistaken osmolal gap in a patient with diabetic ketoacidosis American Journal of Respiratory and Critical Care Medicine 2017; 195PMID: Not assigned. Abstract

Farhan S, Neme K, Mikulandric N, Ruemenapp K, Trapp MA, Bazydlo M, Peres E, and Janakiraman N. Early donor chimerism in patients with myeloid malignancies undergoing stem cell transplantation using FluBu4 with and without busulfan pharmacokinetics compared to busulfan and cyclophosphamide Biol Blood Marrow Transplant 2017; 23(3):S271. PMID: Not assigned. Abstract

Glynn M, Jantz A, Summers B, Salgia R, and Sulejmani N. Safety of statin therapy after liver transplantation Am J Transplant 2017; 17:585. PMID: Not assigned. Abstract

Kaurala SA, Veve M, Van Lare J, Mansour JS, Andrews M, Brown KA, and Davis S. Measures of adherence to HCV therapy in a specialty pharmacy setting and association with NON-SVR Hepatology 2017; 66:594A-594A. PMID :Not assigned. Abstract

Lipari M, Smith AL, Kale-Pradhan P, and Wilhelm S. Adherence to gold guidelines in the inpatient COPD population Pharmacotherapy 2016; 36(12):E272-E272. PMID: Not assigned. Abstract

Sulejmani N, Albanna H, Rendulic T, Summers B, and Jantz A. Clinic-based medication education pilot program Am J Transplant 2017; 17:754. PMID: Not assigned. Abstract

To L, Jantz A, Hencken L, William C, and Nemeh H. Safety and efficacy of four factor prothrombin complex concentrate for the reversal of warfarin in lvad patients prior to heart transplantation J Heart Lung Transplant 2017; 36(4):S365-S365. PMID: Not assigned. Abstract

Walker E, Jones M, Mlynarek M, Starosta K, and To L. A comparison of the efficacy, safety, and costs of intravenous nitroprusside and nicardipine Pharmacotherapy 2016; 36(12):E216-E216. PMID: Not assigned. Abstract

PUBLIC HEALTH SCIENCES

Abdelrahim E, Eng M, Gorgis S, Mawri S, Wang DD, Greenbaum A, Mahan M, Wyman J, Paone G, and O'Neill W. Predictors of late bleeding in the tavr population J Am Coll Cardiol 2017; 69(11):1298-1298. PMID: Not assigned. Abstract

Abdollah F, Nocera L, Sood A, Dalela D, Karabon P, Rogers C, Peabody J, Briganti A, Montorsi F, and Menon M. Testing the external validity of ProtecT trial results in North American men with clinically localized prostate cancer (PCa) Eur Urol, Supplements 2017; 16(3):e78-e79. PMID: Not assigned. Abstract

Affan M, Kananeh M, Schultz L, Elias S, and Cerghet M. Disease course and treatment of neurosarcoidosis in a single center cohort study of 113 cases Neurology 2017; 88(16)PMID: Not assigned. Abstract

142

Al-Darzi W, Nowak R, Hudson M, Moyer ML, Jacobsen G, and McCord J. Ischemicst-segment changes on electrocardiogram in acute myocardial infarction-still common? J Gen Intern Med 2017; 32(2):S235-S236. PMID: Not assigned. Abstract

Bajjoka I, Yaldo A, Crombez C, Brown K, and Abouljoud M. Long-term preservation of renal function in liver transplant recipients with rabbit anti-thymocyte globulin induction and delayed initiation of calcineurin inhibitors Am J Transplant 2017; 17:775. PMID: Not assigned. Abstract

Bossick A, Wegienka G, and Sangha R. Association between patient depression level and hysterectomy satisfaction J Minim Invasive Gynecol 2017; 24(7):S84. PMID: Not assigned. Abstract

Brodie S, Cazacu S, Poisson L, Kalkanis S, Ginsburg D, and Brodie C. The novel long non-coding RNA TALNEC2 regulates the stemness and mesenchymal transformation of glioma stem cells and their exosomemediated interaction with microglia cells J Extracell Vesicles 2017; 6:7. PMID: Not assigned. Abstract

Bryson TD, Gu X, Zhu L, Xu J, Peterson E, Yang XP, and Harding P. Overexpression of prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction FASEB Journal 2017; 31(1)PMID: Not assigned. Abstract

Casso D, Phillips S, Woodcroft K, Sidovar M, Oliveria S, Trudeau J, and Sidovar M. Assessment of cognitive impairment, treatment adherence, and healthcare resource utilization among treated schizophrenia patients Schizophrenia Bulletin 2017; 43:S127-S127. PMID: Not assigned. Abstract

Cerghet M, Poisson L, Dutta I, Suhil H, Elias SB, Giri S, and Mangalam A. A blood-based, six metabolite signature for relapsing-remitting multiple sclerosis Mult Scler J 2017; 23(1):14-14. PMID: Not assigned. Abstract

Chang P, Chow D, Bota D, Poisson L, Filippi C, and Jain R. Deep learning for survival predicting in IDH wild- type gliomas Neuro-Oncol 2017; 19:vi164. PMID: Not assigned. Abstract

Chen KM, Stephen JK, Datta I, Chitale D, Divine G, and Worsham MJ. MicroRNA methylomes of normal breast tissue from ER negative and ER positive breast cancer identify progression markers specific for estrogen receptor status Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Dalela D, Sun M, Diaz M, Karabon P, Seisen T, Trinh QD, Menon M, and Abdollah F. Contemporary trends in the incidence of metastatic prostate cancer among us men: Results from nationwide analyses Eur Urol Focus 2017;PMID: Not assigned. Abstract

DeCarvalho AC, Kim H, Poisson L, Koeman J, Mikkelsen T, and Verhaak R. Discordant inheritance of chromosomal and extrachromosomal DNA elements contribute to dynamic disease evolution in glioblastoma Neuro- Oncology 2017; 19:vi97. PMID: Not assigned. Abstract

Dharaiya D, Modi S, Schultz L, and Varelas P. Drug intoxication and increased mortality in anoxic brain injury Neurocrit Care 2017; 27(2):S29. PMID: Not assigned. Abstract

Elisevich K, Mahmoudi F, Bagher-Ebadian H, Nazem-Zadeh MR, Schwalb J, Kaur M, and Soltanian-Zadeh H. Data miningmrimage features of select structures for lateralization of mesial temporal lobe epilepsy Epilepsia 2017; 58:S67-S67. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Wang Y, Jamil M, Matthews A, Yousif M, Richardson D, Atiemo HO, and Luck A. Longterm follow up in patients with mid-urethral slings with BMI greater than 40 Neurourol Urodyn 2017; 36:S147. PMID: Not assigned. Abstract

ElShatanoufy S, Wang Y, Matthews A, Jamil ML, Yousif M, Gutta S, Gill H, and Luck A. Effect of morbid obesity on mid-urethral sling effecacy for the management of stress urinary incontinence Female Pelvic Med Reconstr Surg 2017; 23(5):S41. PMID: Not assigned. Abstract

Evans KL, Wirtz H, Li J, She RC, Maya J, Depre C, Hamer A, and Lanfear D. Genetics of heart rate observational study (genhrate) J Am Coll Cardiol 2017; 69(11):685-685. PMID: Not assigned. Abstract

143 Farhan S, Neme K, Mikulandric N, Ruemenapp K, Trapp MA, Bazydlo M, Peres E, and Janakiraman N. Early donor chimerism in patients with myeloid malignancies undergoing stem cell transplantation using FluBu4 with and without busulfan pharmacokinetics compared to busulfan and cyclophosphamide Biol Blood Marrow Transplant 2017; 23(3):S271. PMID: Not assigned. Abstract

Frisch NB, Evans TJ, Dobson C, Wang Y, Levin AM, Gibson G, Mott MP, and Parsons TW. Validation of a rat model for analyzing microRNA in CHONDROSARCOMA J Orthop Res 2017; 35PMID: Not assigned. Abstract

Ghanem AI, Tanbour HE, Burmeister C, and Elshaikh MA. The influence of comorbidity on utilization of adjuvant therapies in women with stage III endometrial carcinoma J Rad Oncol 2017; 6(3):245. PMID: Not assigned. Abstract

Ghanem AI, Mannari A, Schymick MA, Burmeister C, Ghanem T, Chang S, and Siddiqui F. The effect of treatment package time in head and neck cancer patients treated with adjuvant radiation therapy and concurrent systemic therapy Int J Radiat Oncol Biol Phys 2017; 99(2):E204. PMID: Not assigned. Abstract

Ghanem AI, Modh A, Burmeister C, Buekers T, and Elshaikh MA. Does interval between hysterectomy and start of radiation treatment influence survival in early stage endometrial carcinoma? a national cancer database analysis Int J Radiat Oncol Biol Phys 2017; 99(2):E292. PMID: Not assigned. Abstract

Girotra T, Affan M, Marin H, Schultz L, and Miller D. Factors affecting distal hyperintense vessel sign, a postulated marker for intracranial collateral circulation Neurology 2017; 88(16)PMID: Not assigned. Abstract

Greenlee H, Neugut AI, Shi Z, Hillyer G, Buono D, Mandelblatt JS, Roh JM, Ergas IJ, Kwan ML, Lee M, Tsai WY, Lamerato LE, Kushi LH, and Hershman DL. Complementary and alternative medicine use and hormonal therapy initiation in women with hormone receptor-positive breast cancer: The BQUAL study J Clin Oncol 2017; 35(15) PMID: Not assigned. Abstract

Harrison M, Assar S, Saeed A, and Li J. Death by kayexalate: Intestinal necrosis in the treatment of hyperkalemia J Hosp Med 2017; 12(s2) PMID: Not assigned. Abstract

Hofmeister MG, Xing J, Moorman AC, Rupp LB, Gordon SC, Boscarino JA, Schmidt MA, Daida YH, Lu M, Teshale EH, Holmberg SD, Spradling PR, and Investigators CH. Health outcomes among surveyed patients infected with hepatitis C in the Chronic Hepatitis Cohort Study (CHeCS) Hepatology 2017; 66:559A-559A. PMID: Not assigned. Abstract

Hou J, Weatherly J, Sellin J, Kaur M, Metwally M, Vrabie R, Ali T, Kaurk N, Gasche C, Drazain N, Oberai R, Nguyen A, Weaver A, Siegel C, and Melmed G. Feasibility of screening for anemia using the crohn's and colitis foundation anemia care pathway in ibd qorus Inflamm Bowel Dis 2017; 23:S46-S47. PMID: Not assigned. Abstract

Irshad K, Schultz L, Zahoor S, and Malik S. Moyamoya and ethnic diversity Neurology 2017; 88(16) PMID: Not assigned. Abstract

Jaehne AK, Chen Y, Schoenling A, Gill JK, Deledda J, Poisson L, and Rivers EP. Sepsis-3 the dysregulated host response and cytokine changes Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Jain T, Nowak R, Hudson M, Moyer M, Jacobsen G, and McCord J. How often does troponin elevation identify acute myocardial infarction in the emergency department? J Am Coll Cardiol 2017; 69(11):1191-1191. PMID: Not assigned. Abstract

Jain R, Poisson LM, Littig I, Neto L, Wu CC, Ng V, Patel SH, Snuderl M, Zagzag D, Golfinos J, and Chi AS. Correlation between IDH mutation status, patient survival, and blood volume estimates in diffuse gliomas: A TCGA/TCIA project Neuro-Oncology 2017; 19:vi149. PMID: Not assigned. Abstract

Jiagge EM, Jibril A, Divine G, Gyan KK, Bensenhaver JM, Oppong JK, Awuah B, Adjei E, Merajver S, Wicha M, Newman LA, and Ford H. Beyond triple-negative breast cancer and African ancestry: Tumor phenotypes among internationally diverse patient populations J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Jindal T, Dalela D, Karabon P, Vetterlein M, Seisen T, Sood A, Trinh QD, Jeong W, Menon M, and Abdollah F. Survival associated with radical prostatectomy versus radiotherapy for high-risk prostate cancer: A contemporary, nationwide observational analysis Eur Urol, Supplements 2017; 16(3):e40. PMID: Not assigned. Abstract

144 Katramados AM, Marin H, Kole M, Varelas P, Miller D, Malik S, Hefzy H, Modi S, Schultz L, Marmagkiolis K, Tsitlakidou D, Affan M, and Mitsias P. Analysis of hypoplastic variants of the circle of willis in patients with first-ever lacunar stroke Stroke 2017; 48PMID: Abstract

King D, Silverstein JM, Roe ED, Munir KM, Fox JL, Thomas A, Kouznetsova M, and Lamerato LE. The medical picture of acromegaly in acromedic, a retrospective database of electronic health records (EHR) from patients with confirmed acromegaly diagnoses across a consortium of four hospital systems in the USA Endocrine Reviews 2017; 38(3) PMID: Not assigned. Abstract

Kumbar L, Zasuwa G, Zaborowicz M, Taylor A, and Yee J. Post-angioplasty changes in venous access pressure ratio is a novel diagnostic tool predicting access failure Am J Kidney Dis 2017; 69(4):A60-A60. PMID: Not assigned. Abstract

Li J, Gordon SC, Rupp LB, Zhang TL, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida Y, and Lu M. Does Hepatitis C eradication lead to improved glucose metabolism, renal and cardiovascular outcomes in diabetic patients? Hepatology 2017; 66:525A-525A. PMID: Not assigned. Abstract

Li J, Zhang TL, Gordon SC, Rupp LB, Trudeau S, Holmberg SD, Moorman AC, Spradling PR, Teshale EH, Boscarino JA, Schmidt MA, Daida YH, Lu M, and For The Chronic Hepatitis Cohort S. Impact of sustained virological response on incidence of type 2 diabetes in hepatitis c patients Hepatology 2017; 66:531A-531A. PMID: Not assigned. Abstract

Löppenberg B, Sood A, Dalela D, Karabon P, Sammon J, Vetterlein M, Noldus J, Peabody J, Trinh QD, Menon M, and Abdollah F. Variation in prostate cancer care at commission on cancer designated facilities Eur Urol, Supplements 2017; 16(3):e1393-e1394. PMID: Not assigned. Abstract

Lu M, Zhou YR, Haller I, Romanelli R, VanWormer JJ, Rodriguez CV, Anderson H, Boscarino JA, Schmidt MA, Daida Y, Sahota AK, Vincent J, Bowlus CL, Lindor KD, Zhang T, Trudeau S, Li J, Rupp LB, Gordon SC, and Fibrotic Liver Dis FC. Epidemiologic trends and treatment survival benefits in a US cohort of patients with primary biliary cholangitis (PBC) Hepatology 2017; 66:157A-157A. PMID: Not assigned. Abstract.

Lupak O, Bazydlo M, Siddiqui F, Chang S, Coniglio B, and Wang D. Timing of percutaneous endoscopic gastrostomy (PEG) tube placement as supportive care in HNSCC patients (Pts) receiving concurrent chemoradiotherapy (CRT) J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Mahmoudi F, Poisson L, Bagher-Ebadian H, Nazem-Zadeh M, and Soltanian-Zadeh H. SU-F-R-02: Imaging- genomics for predicting gbm molecular subclasses and survival Med Phys 2016; 43(6):3373. PMID: 28047590. Abstract

Mann ET, Havstad SL, Sitarik A, Bellemore SM, Levin AM, Lynch SV, Ownby DR, Johnson CC, Lukacs NW, Zoratti EM, Woodcroft KJ, and Bobbitt KR. Characterization of basophils in infants in the microbes, allergy, asthma and Pets (MAAP) birth cohort J Allergy Clin Immunol 2017; 139(2):AB168. PMID: Not assigned. Abstract

Memon A, Madani S, Schultz L, Grover K, Arcila-Londono X, Sripathi N, and Ahmad B. Terminal latency index (TLI) and sensory electrophysiology in paraproteinemic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Neurology 2017; 88(16)PMID: Not assigned. Abstract

Memon A, Madani S, Ahmad BK, Schultz L, Grover K, Arcila-Londono X, and Sripathi N. Does electrophysiology and treatment response differ in idiopathic vs diabetic chronic inflammatory demyelinating polyneuropathy (CIDP)? J Peripher Nerv Syst 2017; 22(3):340-341. PMID: Not assigned. Abstract

Modh A, Burmeister C, Elshaikh MA, Siddiqui F, Siddiqui S, and Shah MM. Radiation utilization trends in the treatment of brain metastases from non-small cell lung cancer Int J Radiat Oncol Biol Phys 2017; 99(2):E94. PMID: Not assigned. Abstract

Modh A, Ghanem AI, Burmeister C, Hanna RK, and Elshaikh MA. What is the optimal adjuvant treatment sequence for node-positive endometrial cancer? Int J Radiat Oncol Biol Phys 2017; 99(2):E303-E304. PMID: Not assigned. Abstract

Morales D, Zolondek R, Craig D, Qiu S, Baugh A, Levin A, Fedorov A, Khuder S, Mopidevi B, and Willey J. Strategies to identify common low effect COPD risk variants Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

145 Morris DC, Cheung WL, Chopp M, Zhang T, and Zhang Z. Beta-aminoisobutyric induces neurite outgrowth in primary cortical neurons Acad Emerg Med 2017; 24:S195. PMID: Not assigned. Abstract

Morris D, Chopp M, Cheung WL, Zhang T, Lu M, and Zhang ZG. Reactive gliosis improves outcome in an aged rat model of embolic stroke Stroke 2017; 48PMID: Not assigned. Abstract

Morris E, Price R, Kim J, Schultz L, Chetty I, and Glide-Hurst C. Performance of synthetic CT for partial brain IGRT Med Phys 2017; 44(6):3039. PMID: Not assigned. Abstract

Noh T, Felicella M, Poisson L, Zakaria HM, DeCarvalho A, Broadbent B, Auner G, and Kalkanis S. Raman laser damage threshold of rat pial cortex Neuro-Oncology 2017; 19:vi239. PMID: Not assigned. Abstract

Noll S, Lawler S, McCord J, Hudson M, Moyer M, Jacobsen G, and Nowak R. Short-term prognostic utility of low, intermediate, and high heart scores in patients presenting to the emergency department with possible acute myocardial injury Acad Emerg Med 2017; 24:S53. PMID: Not assigned. Abstract

Nowak R, Al-Darzi W, Noll S, Hudson M, Moyer M, Jacobsen G, and McCord J. Decreasing ischemic electrocardiocraphic changes in patients diagnosed with acute myocardial infarction in the era of high sensitivity troponin assays Acad Emerg Med 2017; 24:S18. PMID: Not assigned. Abstract

Nowak R, Jain T, Hrabec D, Moyer M, Hudson M, Jacobsen G, and McCord J. Elevated troponin values in the emergency department: Most often not associated with acute myocardial infarction Acad Emerg Med 2017; 24:S253. PMID: Not assigned. Abstract

Orandi D, Havstad S, Sitarik A, Bobbitt K, Jones K, Levin A, Lukacs N, Lynch SV, Wegienka G, Woodcroft K, Ownby D, Johnson C, and Zoratti E. An analysis of potential associations between delivery mode and dog- keeping to basophil FCER1 and activation marker expression during infancy J Allergy Clin Immunol 2017; 139(2):AB167. PMID: Not assigned. Abstract

Park K, Choi S, Ali H, Divine G, Bensenhaver J, Nathanson D, Proctor E, Petersen L, and Newman L. Clinicopathologic features and models predicting for high-risk 21-gene recurrence score (RS) are unreliable in predicting primary tumor downstaging with neoadjuvant chemotherapy (NACT) Ann Surg Oncol 2017; 24(1):S49- S50. PMID: Not assigned. Abstract

Phillips S, Johnson K, Shen SW, Woodcroft KJ, Oliveria SA, and Simon TA. Development of a multi-phase claims- based algorithm for pregnancy research Pharmacoepidemiol Drug Saf 2017; 26:95-96. PMID: Not assigned. Abstract

Phillips S, Sidovar M, Casso D, Trudeau JJ, Woodcroft KJ, and Oliveria SA. Can valid cases of schizophrenia be identified in administrative claims data? Pharmacoepidemiol Drug Saf 2017; 26:65. PMID: Not assigned. Abstract

Phillips S, Johnson KE, Shen SW, Woodcroft KJ, Oliveria SA, and Simon TA. Developing a multi-phase claims- based algorithm to facilitate the study of drug exposure during pregnancy Arthritis Rheum 2017; 69PMID: Not assigned. Abstract

Price K, Doleh Y, Eaddy M, Ogbonnaya A, Shih HC, Ahmad H, Lamerato L, and Szymialis A. First-line treatment patterns of patients with rheumatoid arthritis who are anti-cyclic citrullinated peptide antibody positive versus negative Ann Rheum Dis 2017; 76:842-843. PMID: Not assigned. Abstract

Sabedot TS, Poisson L, DeCarvalho AC, and Noushmehr H. Depletion of 5-hydroxymethylcytosine in aggressive G-CIMP subtype Neuro-Oncology 2017; 19:vi105. PMID: Not assigned. Abstract

Sangha R, Saeed H, Bossick A, and Wegeinka G. Do women express regret after hysterectomy? J Minim Invasive Gynecol 2017; 24(7):S38-S39. PMID: Not assigned. Abstract

Shah K, Alshammaa A, Affan M, Schultz L, and Zaman I. MyChart enrollment and other factors that affect no show rates in the neurology resident clinic Neurology 2017; 88(16)PMID: Not assigned. Abstract

Shah K, Mayer SA, Kole MK, Marin HL, Schultz L, and Miller DJ. Does administration of intravenous contrast impact outcomes upon large vessel occlusion patients undergoing intra-arterial therapy? Interventional Neurology 2017; 6:91. PMID: Not assigned. Abstract

146 Sherenian MG, Cho SH, Levin AM, Min JY, Sen S, Oh S, Huntsman S, Eng C, Farber HJ, Rodriguez-Cintron W, Rodriguez-Santana JR, Serebrisky D, Borrell L, Williams LK, Thyne S, Seibold MA, Burchard E, and Kumar R. PAI- 1 gain of function genotype and airway obstruction in asthma J Allergy Clin Immunol 2017; 139(2):AB171. PMID: Not assigned. Abstract

Silpa-Archa N, Griffith JL, Huggins RH, Henderson MD, Kerr HA, Jacobsen G, Mulekar SV, Lim HW, and Hamzavi IH. Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas J Am Acad Dermatol 2017; 77(2):318-327. PMID: Not assigned. Abstract

Smith D, Johnson E, Go A, Reynolds K, Cassidy-Bushrow A, Mane KK, Yang X, Thompson J, Petrik A, Behr S, Singh P, and Schlienger R. Assessment of potential confounding bias in historical new users of ace inhibitors (ACEIS) Pharmacoepidemiol Drug Saf 2017; 26:92. PMID: Not assigned. Abstract

Stephen JK, Mei Chen K, Merritt J, Datta I, Chitale D, Divine G, and Worsham MJ. Methylome differences in differentiated thyroid cancers and benign Adenomas Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Straughen JK, Misra DP, Divine G, Shah R, Perez G, VanHorn S, Onbreyt V, Dygulska B, Schmitt R, Lederman S, Narula P, and Salafia CM. The association between placental histopathology and autism spectrum disorder Placenta 2017; 57:183-188. PMID: Not assigned. Abstract

Thaxton S, Rouen P, Groh C, Li J, and Peterson E. Practice standards and health-related quality of life in kidney disease Am J Kidney Dis 2017; 69(4):A97-A97. PMID: Not assigned. Abstract

Umar B, Chang S, Ghanem T, Siddiqui F, Jacobsen G, Isrow D, and Keller CE. Does the extent of extracapsular spread in lymph node metastases correlate with outcomes in oropharyngeal squamous cell carcinoma? - a retrospective study Lab Invest 2017; 97:334A-334A. PMID: Not assigned. Abstract

Varelas PN, Brady P, Kananeh M, Louchart L, Mehta C, Schultz L, Abdelhak T, Mayer SA, and Rehman MF. Single versus dual brain death examination in donors does not influence the number of organs recovered or transplanted Neurocritical Care 2017; 27(2):S57. PMID: Not assigned. Abstract

Vega JEV, Halani SH, Yousefi S, Amrollahi F, Holder CA, Poisson LM, Griffith B, Eschbacher J, Nalisnik M, Olson JJ, Cooper LAD, and Brat DJ. Markers of progression in oligodendroglioma Lab Invest 2017; 97:438A-438A. PMID: Not assigned. Abstract

Vega JV, Halani S, Yousefi S, Amrol-Lahi F, Holder C, Poisson L, Griffith B, Eschbacher J, Nalisnik M, Olson J, Cooper L, and Brat D. The Role of NOTCH1 and PI3K Pathways In The Progression of Oligodendrogliomas J Neuropathol Exp Neurol 2017; 76(6):515-515. PMID: Not assigned. Abstract

Watza D, Lusk C, Wenzlaff A, Neslund-Dudas C, Dyson G, Soubani A, Gadgeel S, and Schwartz AG. Immune/inflammatory polymorphisms predict lung cancer survival Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Willey J, Yeo J, Chen T, Crawford EL, Zhang X, Khuder S, and Levin A. Genome maintenance gene regulation in normal bronchial epithelial cells by CEBP and TP53 transcription factor families is different in COPD subjects Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Worsham MJ, Chen KM, Datta I, Stephen JK, Chitale D, and Divine G. Network integration of epigenomic data: Leveraging the concept of master regulators in ER negative breast cancer Cancer Research 2017; 77:1. PMID: Not assigned. Abstract

RADIATION ONCOLOGY

Arbab AS, Jain M, Achyut B, Angara K, Rashid MH, Iskander A, Borin TF, Zhi W, Ara R, Lebedyeva I, and Bagher- Ebadian H. Magnetic resonance imaging based analysis of tumor growth and vascular parameters in animal model of GBM following IV formulated of HET0016 treatments Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Bagher-Ebadian H, Chetty I, Liu C, Movsas B, and Siddiqui F. SU-F-R-38: Impact of smoothing and noise on robustness of cbct textural features for prediction of response to radiotherapy treatment of head and neck cancers Med Phys 2016; 43(6):3381. PMID: 28046928. Abstract

147 Bagher-Ebadian H, Dehkordi A, and Ewing J. SU-F-I-26: Maximum likelihood and nested model selection techniques for pharmacokinetic analysis of dynamic contrast enhanced mri in patients with glioblastoma tumors Med Phys 2016; 43(6):3392. PMID: 28048158. Abstract

Bagher-Ebadian H, Mohammadian Behbahani M, and Ewing J. WE-FG-206-03: An adaptive model for pharmacokinetic nested model selection in dynamic contrast enhanced mri data analysis Med Phys 2016; 43(6):3831. PMID: 28048278. Abstract

Bagher-Ebadian H, Janic B, Liu C, Pantelic M, Hearshen D, Chetty IJ, Elshaikh M, Movsas B, and Wen N. An equilibrium model for characterization and classification of dominant intraprostatic lesions and normal tissues in patients with prostate cancer Med Phys 2017; 44(6):3096. PMID: Not assigned. Abstract

Bagher-Ebadian H, Wu Q, Siddiqui F, Liu C, Ajlouni M, Movsas B, and Chetty IJ. Deriving radiomics features from CT images using a partial least square correlation technique in the lung cancer setting Med Phys 2017; 44(6):3213. PMID: Not assigned. Abstract

Bagher-Ebadian H, Janic B, Liu C, Pantelic M, Hearshen D, Chetty I, Elshaikh M, Movsas B, and Wen N. Examination and evaluation of MR radiomics features for characterization of dominant intraprostatic lesions Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Bagher-Ebadian H, Janic B, Liu C, Pantelic M, Hearshen D, Elshaikh MA, Movsas B, Chetty IJ, and Wen N. Detection of dominant intraprostatic lesions in patients with prostate cancer using an artificial neural network and MR multimodal radiomics analysis Int J Radiat Oncol Biol Phys 2017; 99(2):S82-S83. PMID: Not assigned. Abstract

Bismack B, Gopal A, Wen N, Kim J, Laugeman E, Dumas M, Miller B, and Chetty I. Commissioning of a model based 3d second check and PSQA system Med Phys 2017; 44(6):2891-2892. PMID: Not assigned. Abstract

Boyce-Fappiano D, Elibe E, Siddiqui MSU, Lee I, Rock J, and Siddiqui F. Incidence of local and marginal treatment failure following postoperative single fraction spine stereotactic radiosurgery Int J Radiat Oncol Biol Phys 2017; 99(2):E517. PMID: Not assigned. Abstract

Chetty I, Paysan P, Siddiqui F, Mao W, Brehm M, Messmer P, Maslowski A, Wang A, Seghers D, and Munro P. Improving CBCT image quality for daily image guidance of patients with head/neck and prostate cancer Radiother Oncol 2017; 123:S491-S492. PMID: Not assigned. Abstract

Chetty IJ, and Fontenot J. Adaptive Radiation Therapy: Off-Line, On-Line, and In-Line? Int J Radiat Oncol Biol Phys 2017; 99(3):689-691. PMID: Not assigned. Abstract

Chetvertkov M, Siddiqui F, Chetty I, Kumarasiri A, Liu C, and Gordon J. SU-F-R-41: Regularized pca can model treatment-related changes in head and neck patients using daily cbcts Med Phys 2016; 43(6):3382. PMID: 28046748. Abstract

Cunningham JM, Barberi E, Miller J, and Glide-Hurst C. Development of novel pelvic end-to-end (PETE) phantom for mronly radiotherapy: Patient-informed design considerations Med Phys 2017; 44(6):3137-3138. PMID: Not assigned. Abstract

Cunningham JM, and Glide-Hurst C. End-to-end phantom evaluation for transition from MR/CT combined to MR- Only workflow Med Phys 2017; 44(6):2818. PMID: Not assigned. Abstract

Devpura S, Li H, Liu C, Fraser C, Ajlouni M, Movsas B, and Chetty I. SU-D-204-07: Retrospective correlation of dose accuracy with regions of local failure for early stage lung cancer patients treated with stereotactic body radiotherapy Med Phys 2016; 43(6):3333. PMID: 28048314. Abstract

Devpura S, Feghali K, Sun Z, Wu Q, Liu J, Ajlouni M, and Chetty I. Retrospective correlation of radiation pneumonitis with dose distributions computed with different algorithms for locally advanced lung cancer patients Med Phys 2017; 44(6):2846. PMID: Not assigned. Abstract

Dumas M, and Wen N. SU-F-T-578: Characterization of vidar dosimetrypro advantage red scanner with application to sbrt and srs qa Med Phys 2016; 43(6):3596. PMID: 28047018. Abstract

Dumas M, and Wen N. Evaluation of gafchromic EBT-XD film using vidar dosimetrypro advantage red scanner for SRS and SBRT QA Med Phys 2017; 44(6):3119-3120. PMID: Not assigned. Abstract

148 Elibe E, Boyce-Fappiano D, Siddiqui S, Lee I, Rock J, and Siddiqui F. Stereotactic radiosurgery for malignant intradural and intramedullary tumors of the spine Int J Radiat Oncol Biol Phys 2017; 99(2):E512-E513. PMID: Not assigned. Abstract

Elibe E, Boyce-Fappiano D, Siddiqui S, Lee I, Rock J, and Siddiqui F. Repeat courses of spine stereotactic radiosurgey (SRS): Efficacy and toxicity Int J Radiat Oncol Biol Phys 2017; 99(2):E518-E519. PMID: Not assigned. Abstract

Eraj S, Jomaa M, Rock CD, Mohamed ASR, Hutcheson KA, Sturgis EM, Lu C, Morrison WH, Rosenthal DI, Frank SJ, Garden AS, Fuller CD, and Gunn GB. Long-term patient report outcomes following radiation therapy for early stage base of tongue carcinoma: A symptom assessment study Int J Radiat Oncol Biol Phys 2017; 99(2):E202. PMID: Not assigned. Abstract

Gardner S, Doemer A, Miller B, Wen N, and Chetty I. SU-G-BRC-07: Evaluation of AAA focal spot size for srs planning using end-to-end dosimetric data Med Phys 2016; 43(6):3628. PMID: 28048385. Abstract

Gerber DE, Urbanic JJ, Langer CJ, Hu C, Chang IF, Lu B, Movsas B, Jeraj R, Curran WJ, and Bradley JD. Randomized phase III trial of concurrent chemoradiation followed by nivolumab or placebo for locally advanced non- small cell lung cancer (NSCLC) (RTOG 3505) J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Ghanem AI, Tanbour HE, Burmeister C, and Elshaikh MA. The influence of comorbidity on utilization of adjuvant therapies in women with stage III endometrial carcinoma J Rad Oncol 2017; 6(3):245. PMID: Not assigned. Abstract

Ghanem AI, Mannari A, Schymick MA, Burmeister C, Ghanem T, Chang S, and Siddiqui F. The effect of treatment package time in head and neck cancer patients treated with adjuvant radiation therapy and concurrent systemic therapy Int J Radiat Oncol Biol Phys 2017; 99(2):E204. PMID: Not assigned. Abstract

Ghanem AI, Modh A, Burmeister C, Buekers T, and Elshaikh MA. Does interval between hysterectomy and start of radiation treatment influence survival in early stage endometrial carcinoma? a national cancer database analysis Int J Radiat Oncol Biol Phys 2017; 99(2):E292. PMID: Not assigned. Abstract

Glide-Hurst C, Zheng W, Stehning C, Weiss S, and Renisch S. SU-G-JeP2-10: On the need for a dynamic model for patient-specific distortion corrections for mr-only pelvis treatment planning Med Phys 2016; 43(6):3661. PMID: 28048910. Abstract

Gopal A, Laugeman E, Kim J, Dumas M, Huang Y, Wen N, Shi J, Simon B, and Chetty I. Preliminary evaluation of a reference detector measuring leakage radiation for use in small field beam data acquisition Med Phys 2017; 44(6):2950. PMID: Not assigned. Abstract

Harkenrider MM, Adams W, Nieto K, Aref I, Bergman DM, Chundury A, Elshaikh MA, Gaffney DKK, Jhingran A, Lee LJ, Paydar I, Ra K, Schwarz JK, Thorpe C, Viswanathan AN, and Small W. Multi-institutional analysis of vaginal brachytherapy without external beam radiation therapy for stage II endometrial cancer patients Int J Radiat Oncol Biol Phys 2017; 99(2):S112. PMID: Not assigned. Abstract

Hillman Y, Kim J, Chetty I, and Wen N. Evaluation of QA dosimetry system for SRS and SBRT patient-specific QA Med Phys 2017; 44(6):3273. PMID: Not assigned. Abstract

Hitchcock K, Bradley JD, Morris CG, Hu C, Paulus R, Movsas B, and Hoppe BS. Quality of survivorship among patients with locally advanced NSCLC treated with chemoradiation on RTOG 0617 Int J Radiat Oncol Biol Phys 2017; 99(2):E461. PMID: Not assigned. Abstract

Huang Y, Gardner S, Liu C, Zhao B, Wen N, Brown S, and Chetty I. SU-F-J-11: Radiobiologically optimized patient localization during prostate external beam localization Med Phys 2016; 43(6):3408. PMID: 28046819. Abstract

Isrow D, Brown SL, and Kim JH. Theranostic applications of pair-production for enhancing radiation therapy Int J Radiat Oncol Biol Phys 2017; 99(2):E672-E673. PMID: Not assigned. Abstract

Janic B, Brown S, Bagher-Ebadian H, Liu F, Mao G, Chetty I, Movsas B, and Wen N. Gold nanoparticle radio- sensitization of MCF-7 breast cancer cells Med Phys 2017; 44(6):3063-3064. PMID: Not assigned. Abstract

149 Kim G, Muir B, Culberson W, Davis S, Huang Y, Lee S, Lowenstein J, Sarfehnia A, Tolani N, and Siebers J. TU- D- 201-03: Results of a survey on the implementation of the tg-51 protocol and associated addendum on reference dosimetry of external beams Med Phys 2016; 43(6):3743. PMID: 28047408. Abstract

Kim J, Myers E, Forbes M, Chetty I, and Glide-Hurst C. SU-G-IeP2-07: Investigation of 3d-printed phantoms for synthetic ct benchmarking in an mr-only workflow Med Phys 2016; 43(6):3657. PMID: 28046242. Abstract

Kim J, Ghanem A, Elshaikh M, Chetty I, and Glide-Hurst C. Optimization of synthetic ct for female pelvis Med Phys 2017; 44(6):3044. PMID: Not assigned. Abstract

Kumarasiri A, Liu C, Brown S, Glide-Hurst C, Elshaikh M, Chetty I, and Movsas B. WE-AB-207B-09: Margin reduction for planning target volume (ptv) in patients with localized prostate cancer: Impact on delivered dose and quality of life Med Phys 2016; 43(6):3806. PMID: 28047756. Abstract

Laugeman E, Sevak P, Liu C, Snyder K, Wen N, and Chetty I. Interfraction contour comparison on 4DCBCT Vs. 4DCT for lung SBRT patients Med Phys 2017; 44(6):2985. PMID: Not assigned. Abstract

Lee JK, Zhai T, Jackson P, Wen N, and Siddiqui S. Patient immobilization for stereotactic radiosurgery in the treatment of malignancies of the cervical spine: 9-point mask versus non-9-point mask immobilization system Int J Radiat Oncol Biol Phys 2017; 99(2):E683-E684. PMID: Not assigned. Abstract

Leney M, Kim J, Liu C, Sevak P, Glide-Hurst C, Elshaikh M, Pantelic M, Movsas B, Chetty I, and Wen N. MR- only planning for simultaneous integrated boost of MRI-defined dominant intraprostatic lesions Med Phys 2017; 44(6):3043. PMID: Not assigned. Abstract

Li H, Zhong H, Qin Y, Snyder K, Chetty I, and Wen N. SU-F-T-555: Accurate stereotactic cone tmrs converted from pdds scanned with ray trace Med Phys 2016; 43(6):3591. PMID: 28047603. Abstract

Li H, Jackson P, and Wen N. Accuracy of tumor setup using triggered KV images at multiple gantry angles Med Phys 2017; 44(6):2798-2799. PMID: Not assigned. Abstract

Liu C, Chetty I, Mao W, Kumarasiri A, Zhong H, Brown S, and Siddiqui F. SU-F-J-68: Deformable dose accumulation for voxel-based dose tracking of ptv cold spots for adaptive radiotherapy of the head and neck Med Phys 2016; 43(6):3421-3422. PMID: 28047440. Abstract

Liu C, Siddiqui F, Chetty I, and Mao W. Daily cbct reveals shoulder movement and its dosimetric effects during head and neck IMRT Med Phys 2017; 44(6):3052. PMID: Not assigned. Abstract

Liu M, Wen N, Beyer C, Siddiqui F, Chetty I, and Zhao B. SU-F-T-506: Development and commissioning of the effective and efficient grid therapy using high dose rate flattening filter free beam and multileaf collimator Med Phys 2016; 43(6):3579-3580. PMID: 28048441. Abstract

Lupak O, Bazydlo M, Siddiqui F, Chang S, Coniglio B, and Wang D. Timing of percutaneous endoscopic gastrostomy (PEG) tube placement as supportive care in HNSCC patients (Pts) receiving concurrent chemoradiotherapy (CRT) J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Mahmoudi F, Poisson L, Bagher-Ebadian H, Nazem-Zadeh M, and Soltanian-Zadeh H. SU-F-R-02: Imaging- genomics for predicting gbm molecular subclasses and survival Med Phys 2016; 43(6):3373. PMID: 28047590. Abstract

Mao W, Liu C, Zhong H, Rozario T, Lu W, Gu X, Yan Y, Jia X, Sumer B, and Schwartz D. SU-C-202-05: Pilot study of online treatment evaluation and adaptive re-planning for laryngeal sbrt Med Phys 2016; 43(6):3323-3324. PMID: 28047110. Abstract

Mao W, and Wang G. TU-H-BRA-05: A system design for integration of an interior mri and a linear accelerator Med Phys 2016; 43(6):3769. PMID: 28047265. Abstract

Mao W, Liu C, Snyder K, Kumarasiri A, Zhao B, Gardner S, Kim J, Wen N, Chetty I, and Siddiqui F. A novel iterative reconstruction algorithm for improving CBCT image quality Med Phys 2017; 44(6):3148. PMID: Not assigned. Abstract

Mao W, Snyder K, Gardner S, Wen N, Zhong H, Jackson P, Shah M, and Chetty I. On the improvement of CBCT image quality for soft tissue-based SRS localization Med Phys 2017; 44(6):3203-3204. PMID: Not assigned. Abstract

150

Mao W, Liu C, Snyder K, Zhao B, Gardner SJ, Kumarasiri AD, Kim J, Wen N, Chetty IJ, and Siddiqui F. Can image quality of daily CBCT be improved by a new reconstructor? Int J Radiat Oncol Biol Phys 2017; 99(2):S93. PMID: Not assigned. Abstract

Mayyas E, Vance S, Brown S, Liu J, Kim J, Zhen S, Devpura S, Ajlouni M, Salim S, Chetty I, and Movsas B. WE-AB-207B-12: Prospective study of the relationship between dose-volume clinical toxicity and patient reported outcomes in lung cancer patients treated with SBRT Med Phys 2016; 43(6):3806-3807. PMID: 28048506. Abstract

Mittelstaedt D, Klahr P, Nejad-Davarani S, Schulz H, Goshen L, Morris E, and Glide-Hurst C. Sensitivity of auto- segmentation to CT reconstruction algorithms Med Phys 2017; 44(6):3302. PMID: Not assigned. Abstract

Modh A, Burmeister C, Elshaikh MA, Siddiqui F, Siddiqui S, and Shah MM. Radiation utilization trends in the treatment of brain metastases from non-small cell lung cancer Int J Radiat Oncol Biol Phys 2017; 99(2):E94. PMID: Not assigned. Abstract

Modh A, Ghanem AI, Burmeister C, Hanna RK, and Elshaikh MA. What is the optimal adjuvant treatment sequence for node-positive endometrial cancer? Int J Radiat Oncol Biol Phys 2017; 99(2):E303-E304. PMID: Not assigned. Abstract

Molaeimanesh Z, A NVD, Faghihi R, Elmghirbi R, Ewing J, Wen N, I JC, and Bagher-Ebadian H. Quantitative MR estimation of interstitial fluid pressure in a pre-clinical rat model of glioblastoma tumors using an adaptive model and principle component analysis Med Phys 2017; 44(6):3018-3019. PMID: Not assigned. Abstract

Morris ED, Klahr P, and Glide-Hurst C. MO-DE-207A-12: Toward patient-specific 4dct reconstruction using adaptive velocity binning Med Phys 2016; 43(6):3703. PMID: 28047399. Abstract

Morris ED, Klahr P, and Glide-Hurst C. MO-DE-207A-03: Characterization of potential gains in a novel exponential 4dct reconstruction algorithm Med Phys 2016; 43(6):3700. PMID: 28046714. Abstract

Morris E, Moncion M, Sevak P, Weiss S, Garbarino K, Renisch S, and Glide-Hurst C. Impact of bladder filling on an MR-only pelvis radiotherapy workflow Med Phys 2017; 44(6):2770. PMID: Not assigned. Abstract

Morris E, Price R, Kim J, Schultz L, Chetty I, and Glide-Hurst C. Performance of synthetic CT for partial brain IGRT Med Phys 2017; 44(6):3039. PMID: Not assigned. Abstract

Nagaraja TN, Elmghirbi R, Irtenkauf S, Hasselbach L, Tawil B, Brown SL, Panda S, Cabral G, Mikkelsen T, Ewing JR, and DeCarvalho A. Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patientderived xenograft mouse models of glioblastoma Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Nejad-Davarani S, Weiss S, Sevak P, Renisch S, and Glide-Hurst C. Analysis of temporal patient-specific MR distortions:A per-organ assessment Med Phys 2017; 44(6):3137. PMID: Not assigned. Abstract

Orasanu E, Glide-Hurst C, Stehle T, Buerger C, and Renisch S. Toward automated MR-only planning of the brain: Organ-at-risk segmentation Med Phys 2017; 44(6):3029. PMID: Not assigned. Abstract

Price RG, Kim J, Zheng W, Chetty IJ, and Glide-Hurst C. SU-G-JeP2-08: Image-guided radiation therapy using synthetic cts in brain cancer Med Phys 2016; 43(6):3661. PMID: 28048467. Abstract

Price RG, Knight RA, Hwang K, Bayram E, and Glide-Hurst C. TU-AB-BRA-05: Optimization of a novel large field of view distortion phantom for mr-only treatment planning Med Phys 2016; 43(6):3734. PMID: 28046653. Abstract

Pugh SL, Lee WR, Dignam J, Low D, Swanson GP, Shah AB, D'Souza DP, Michalski JM, Dayes IS, Seaward SA, Nguyen PL, Hall WA, Pisansky TM, Chen Y, Sandler HM, Movsas B, and Bruner DW. NRG Oncology/RTOG 0415, hypofractionation in patients with low-risk prostate cancer: Are patient reported outcomes the practice change tipping point? Quality of Life Research 2017; 26(1):38-39. PMID: Not assigned. Abstract

Qin Y, and Chetty I. SU-F-T-543: The impact of density overrides in imrt and vmat planning for lung cancer patients treated sbrt Med Phys 2016; 43(6):3588. PMID: 28046460. Abstract

151 Qin Y, Gardner S, Huang Y, Kim J, Wen N, and Chetty I. SU-G-TeP2-08: Evaluation of plastic scintillator detector for small field stereotactic patient-specific quality assurance Med Phys 2016; 43(6):3664. PMID: 28047648. Abstract

Qu MX, Velker V, Leung E, Kwon J, Elshaikh MA, Kong I, Logie N, Mendez LC, Van Der Putten L, Donovan E, Munkarah AR, Wiebe EM, Louie AV, and D'Souza DP. The role of adjuvant therapy in stage IA serous and clear cell uterine cancer: A pooled analysis Radiother Oncol 2017; 123:S292. PMID: Not assigned. Abstract

Qu MX, Velker V, Leung EW, Kwon J, Elshaikh MA, Kong I, Logie N, Mendez LC, Van Der Putten L, Donovan E, Munkarah AR, Wiebe EM, Louie AV, and D'Souza DP. Improved disease control with adjuvant therapy for stage IA serous and clear cell uterine cancer: A pooled multi-institutional analysis Int J Radiat Oncol Biol Phys 2017; 99(2):S229. PMID: Not assigned. Abstract

Rozario T, Chiu T, Lu W, Chen M, Yan Y, Bereg S, and Mao W. TH-AB-202-01: Daily lung tumor motion characterization on epids using a markerless tiling model Med Phys 2016; 43(6):3856. PMID: 28047157. Abstract

Rozario T, Chiu T, Chen M, Lu W, Yan Y, Bereg S, and Mao W. Real-time lung tumor tracking on MV bev images using a markerless model Med Phys 2017; 44(6):3270. PMID: Not assigned. Abstracts

Santoso A, Song K, Qin Y, Gardner S, Liu C, Cattaneo R, Chetty I, Movsas B, Aljouni M, and Wen N. SU-F-J-38: Dose rates and preliminary evaluation of contouring similarity metrics using 4d cone beam ct Med Phys 2016; 43(6):3414. PMID: 28048111. Abstract

Sevak PR, Nejad-Davarani S, Kim J, Weiss S, Elshaikh MA, and Glide-Hurst CK. Intrafractional motion of target volumes and organs at risk due to bladder filling: Implications for MR-only prostate radiation therapy Int J Radiat Oncol Biol Phys 2017; 99(2):E720-E721. PMID: Not assigned. Abstract

Sharifi H, Zhang H, Jin JY, Kong FM, Chetty IJ, and Zhong H. TU-AB-202-07: A novel method for registration of mid-treatment pet/ct images under conditions of tumor regression for patients with locally advanced lung cancers Med Phys 2016; 43(6):3738. PMID: 28047401. Abstract

Sharifi H, Glide-Hurst C, Gopal A, Brown S, Chetty IJ, Movsas B, and Zhong H. Evaluation of the physiological response to fractionated radiotherapy Med Phys 2017; 44(6):2813. PMID: Not assigned. Abstract

Sharifi H, Zhang H, Ajlouni M, Jin JY, Kong FM, Chetty IJ, and Zhong H. Investigation of heterogeneous tumor response in adaptive radiation therapy for patients with lung cancer Int J Radiat Oncol Biol Phys 2017; 99(2):E495. PMID: Not assigned. Abstract

Stinchcombe T, Zhang Y, Vokes E, Schiller J, Bradley J, Kelly K, Curran W, Schild S, Movsas B, Clamon G, Govindan R, Blumenschein G, Socinski M, Ready N, Akerley W, Cohen H, Pang H, and Wang X. A pooled analysis comparing the outcomes of elderly to younger patients on nctn trials of concurrent ccrt for stage 3 NSCLC J Thorac Oncol 2017; 12(1):S374-S375. PMID: Not assigned. Abstract

Tsiamas P, Isrow D, Chetty I, Kim J, and Brown S. Dosimetric evaluation of pair production enhanced radiotherapy (PPER) with the use of high-z organometallics Med Phys 2017; 44(6):2997. PMID: Not assigned. Abstract

Umar B, Chang S, Ghanem T, Siddiqui F, Jacobsen G, Isrow D, and Keller CE. Does the extent of extracapsular spread in lymph node metastases correlate with outcomes in oropharyngeal squamous cell carcinoma? - a retrospective study Lab Invest 2017; 97:334A-334A. PMID: Not assigned. Abstract

Videtic GM, Paulus R, Singh AK, Chang JY, Parker W, Olivier K, Timmerman RD, Komaki RU, Urbanic JJ, Stephans KL, Yom SS, Robinson CG, Belani C, Iyengar P, Ajlouni M, Gopaul DD, Lele S, McGarry RC, Choy H, and Bradley JD. Long-term follow-up on NRG oncology RTOG 0915 (NCCTG n0927): A randomized phase 2 study comparing 2 stereotactic body radiation therapy schedules for medically inoperable patients with stage i peripheral non-small cell lung cancer Int J Radiat Oncol Biol Phys 2017; 99(2):S6. PMID: Not assigned. Abstract

Ward MC, Lee N, Caudell JJ, Chagin K, Awan MJ, Koyfman S, Dunlap NE, Zakem SJ, Hassanzadeh CJ, Marcrom S, Boggs H, Isrow D, Vargo JA, Heron DE, Siddiqui F, Dault J, Bonner JA, Beitler JJ, Yao M, and Riaz N. A nomogram to predict severe late toxicity after definitive reirradiation for squamous carcinoma of the head and neck Int J Radiat Oncol Biol Phys 2017; 99(2):S235-S236. PMID: Not assigned. Abstract

152 Weiss S, Nejad-Davarani S, Renisch S, and Glide-Hurst C. Comparison of two methods for patient specific distortion corrections for MR only treatment planning Med Phys 2017; 44(6):3097-3098. PMID: Not assigned. Abstract

Wen N, Lu S, Qin Y, Huang Y, Zhao B, Liu C, and Chetty I. SU-F-T-566: Absolute film dosimetry for stereotactic radiosurgery and stereotactic body radiotherapy quality assurance using gafchromic ebt3 films Med Phys 2016; 43(6):3593. PMID: 28047636. Abstract

Wen N, Snyder K, Scheib S, Qin Y, Li H, and Chetty I. SU-F-J-177: A novel image analysis technique (center pixel method) to quantify end-to-end tests Med Phys 2016; 43(6):3448-3449. PMID: 28046890. Abstract

Williams A, Ghanem T, Siddiqui F, and Chang S. Clinical assessment of cognitive function in head and neck cancer Psycho-Oncology 2017; 26:74-74. PMID: Not assigned. Abstract

Wu Q, Devpura S, Feghali K, Liu C, Ajlouni M, Movsas B, and Chetty I. WE-AB-207B-05: Correlation of normal lung density changes with dose after stereotactic body radiotherapy (sbrt) for early stage lung cancer Med Phys 2016; 43(6):3805. PMID: 28048563. Abstract

Wu Q, Feghali K, Ghanem A, Liu C, Ajlouni M, Movsas B, and Chetty I. Associations between normal lung density changes and radiation-induced pneumonitis after concurrent chemoradiotherapy for patients with locally advanced stage lung cancer Med Phys 2017; 44(6):2847. PMID: Not assigned. Abstract

Wu Q, Liu C, Devpura S, Ajlouni M, Movsas B, and Chetty I. Accumulated dose estimation in lung stereotactic body radiation therapy using deformable image registration algorithm Med Phys 2017; 44(6):3222-3223. PMID: Not assigned. Abstract

Xu H, Chetty I, and Wen N. SU-D-BRA-03: Analysis of systematic errors with 2d/3d image registration for target localization and treatment delivery in stereotactic radiosurgery Med Phys 2016; 43(6):3339-3340. PMID: 28047080. Abstract

Zhao B, Huang Y, Snyder K, Liu C, Chetty I, and Wen N. Feasibility of using machine performance check for daily photon output constancy, and isocentricity QA Med Phys 2017; 44(6):2937-2938. PMID: Not assigned. Abstract

Zhao B, Wen N, Chetty IJ, Huang Y, Brown SL, Snyder KC, Siddiqui F, Movsas B, and Siddiqui MS. A prediction model of radiation-induced necrosis for intracranial radiosurgery based on target volume Med Phys 2017; 44(8):4360-4367. PMID: Not assigned. Abstract

Zhong H, Siddiqui S, Zhao B, Li H, Barton K, Siddiqui F, Movsas B, and Chetty I. SU-F-R-49: A novel kinetic model for prediction of tumor local control for patients with lung cancer Med Phys 2016; 43(6):3384. PMID: 28048749. Abstract

Zhong H, Barton K, Movsas B, and Chetty I. A mathematical model of cancer stem cell kinetics and response to radiation therapy Med Phys 2017; 44(6):2995. PMID: Not assigned. Abstract

RESEARCH ADMINISTRATION

Cytogenetics

Tashakori M, Sanchez J, Michalowski SM, Louissaint A, Inamdar KV, Gomez-Gelvez J, Carey JL, and Menon MP. Follicular lymphoma transforming to double and triple hit lymphoma; a clinicopathologic, morphologic and cytogenetic analysis Lab Invest 2017; 97:380A-381A. PMID: Not assigned. Abstract

Image Analysis Program

Elisevich K, Mahmoudi F, Bagher-Ebadian H, Nazem-Zadeh MR, Schwalb J, Kaur M, and Soltanian-Zadeh H. Data miningmrimage features of select structures for lateralization of mesial temporal lobe epilepsy Epilepsia 2017; 58:S67-S67. PMID: Not assigned. Abstract

Huang P, Shenkov N, Fotouhi S, Davoodi-Bojd E, Lu LJ, Mari Z, Soltanian-Zadeh H, Sossi V, and Rahmim A. Radiomics Analysis of Longitudinal DaTscan Images for Improved Progression Tracking in Parkinson's Disease J Nucl Med 2017; 58:2. PMID: Not assigned. Abstract

153

Mahmoudi F, Poisson L, Bagher-Ebadian H, Nazem-Zadeh M, and Soltanian-Zadeh H. SU-F-R-02: Imaging- genomics for predicting gbm molecular subclasses and survival Med Phys 2016; 43(6):3373. PMID: 28047590. Abstract

Salimpour Y, Davoodi-Bojd E, Fotouhi S, Soltanian-Zadeh H, Mirpour S, Yan R, Sossi V, and Rahmim A. Regional correlation of subcortical structures with clinical phenotypes in Parkinson's disease: DAT SPECT imaging approach J Nucl Med 2017; 58:1. PMID: Not assigned. Abstract

Shenkov N, Klyuzhin I, Fotouhi S, Davoodi-Bojd E, Soltanian-Zadeh H, Rahmim A, and Sossi V. A metric to quantify DaTSCAN tracer uptake in subjects with Parkinson's disease computed without MRI-based regions of interest J Nucl Med 2017; 58:2. PMID: Not assigned. Abstract

Tang J, Yang B, Shenkov N, Fotouhi S, Davoodi-Bojd E, Lu L, Soltanian-Zadeh H, Sossi V, and Rahmim A. Artificial neural network based outcome prediction in DAT SPECT imaging of Parkinson's Disease J Nucl Med 2017; 58:2. PMID: Not assigned. Abstract

SURGERY

Al Adas Z, Lin J, Nypaver T, Weaver MR, Shepard AD, Chau LC, Miller D, and Kabbani L. Natural history of progression of carotid artery stenosis J Vasc Surg 2017; 65(6):50S. PMID: Not assigned. Abstract

Al Adas Z, Nypaver T, Shepard AD, Weaver MR, Malinzak L, Khalid N, Patel A, and Kabbani L. Kidney transplant increases the risk of ipsilateral critical limb ischemia J Vasc Surg 2017; 65(6):117S. PMID: Not assigned. Abstract

Al Adas Z, Shepard AD, Nypaver T, Weaver MR, Maatman T, Yessayan L, and Kabbani L. Long-term decline in renal function is more significant after endovascular repair of infrarenal abdominal aortic aneurysms J Vasc Surg 2017; 65(6):28S-29S. PMID: Not assigned. Abstract

Al Adas Z, Miller D, Weaver M, Shepard A, Nypaver TJ, Nour K, Balraj P, and Kabbani L. Cerebrovascular injuries are commonly found in acute type b aortic dissections and are associated with blood pressure derangements and poor outcome J Vasc Surg 2017; 66(2):E28-E28. PMID: Not assigned. Abstract

Al Adas Z, Shepard A, Nypaver TJ, Weaver M, Balraj P, Huang J, Harriz R, and Kabbani L. Survival after AAA repair is affected by socioeconomic status J Vasc Surg 2017; 66(2):E21-E21. PMID: Not assigned. Abstract

Al-Darzi W, El-Atrache M, Georgie F, Sadiq O, Singla S, Fernandez C, Pompa R, Galusca D, Yoshida A, and Jafri SM. Risk factors and outcomes of intracardiac thrombosis during orthotopic liver transplantation Am J Transplant 2017; 17:582. PMID: Not assigned. Abstract

Bajjoka I, Yaldo A, Crombez C, and Abouljoud M. Long-term outcomes among slow versus delayed or immediate graft function kidney transplant recipients: A single-center experience Am J Transplant 2017; 17:563. PMID: Not assigned. Abstract

Bajjoka I, Yaldo A, Crombez C, Brown K, and Abouljoud M. Long-term preservation of renal function in liver transplant recipients with rabbit anti-thymocyte globulin induction and delayed initiation of calcineurin inhibitors Am J Transplant 2017; 17:775. PMID: Not assigned. Abstract

Balraj P, Kabbani L, Mathews J, Tinney F, Schwartz S, Kwon D, Braun F, and Wasilenko S. Epithelioid hemangioendothelioma presenting as inferior vena cava obstruction diagnosed using an endovascular thrombectomy device Ann Vasc Surg 2017; 40:3. PMID: Not assigned. Abstract

DeMeireles A, Cassidy R, Ross R, Stricklen A, Carlin AM, Finks JF, and Ghaferi AA. Variation in psychological well- being and body image in patients before and after bariatric surgery Surgical Endoscopy and Other Interventional Techniques 2017; 31:S7. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Matthews A, Quinn T, Jesse M, Atiemo HO, and Richardson D. Correlation between michigan incontinence severity index and american urolgical society symptom index in female incontinence patients Neurourol Urodyn 2017; 36:S86. PMID: Not assigned. Abstract

154 Elshatanoufy S, Griffin M, Quinn T, Matthews A, Jesse M, Atiemo HO, and Richardson D. Preliminary exploration: Can suffering and acceptance be found in the discordance between measures? Neurourol Urodyn 2017; 36:S87. PMID: Not assigned. Abstract

Farhan S, Neme K, Mikulandric N, Ruemenapp K, Trapp MA, Bazydlo M, Peres E, and Janakiraman N. Early donor chimerism in patients with myeloid malignancies undergoing stem cell transplantation using FluBu4 with and without busulfan pharmacokinetics compared to busulfan and cyclophosphamide Biol Blood Marrow Transplant 2017; 23(3):S271. PMID: Not assigned. Abstract

Ivanics T, Karamanos E, Gupta AH, Falvo A, Patton JH, and Rubinfeld I. Outcomes of component separation for ventral hernia repair in an emergent setting: Analysis of the american college of surgeons (ACS) NSQIP J Am Coll Surg 2017; 225(4):S164. PMID: Not assigned. Abstract

Ivanics T, Kwon DS, and Rubinfeld I. Impact of extremes of BMI on perioperative complications in complex pancreatic resections J Am Coll Surg 2017; 225(4):E122-E122. PMID: Not assigned. Abstract

Ivanics T, Rubinfeld I, and Kwon DS. Perioperative outcomes for the emergent whipple operation in the united states: An analysis of the american college of surgeons national surgical quality improvement program J Am Coll Surg 2017; 225(4):S135-S136. PMID: Not assigned. Abstract

Jesse M, Kulas M, Unitis J, Beltran N, and Abouljoud M. Pilot study on acupuncture in living liver and kidney donors Am J Transplantation 2017; 17:697. PMID: Not assigned. Abstract

Jesse M, Rebhan N, Yoshida A, Moonka D, Eshelman A, Abouljoud M, and Rizzari M. Substance abuse in acute liver failure: Time to talk about opiates Am J Transplant 2017; 17:240. PMID: Not assigned. Abstract

Jiagge EM, Jibril A, Divine G, Gyan KK, Bensenhaver JM, Oppong JK, Awuah B, Adjei E, Merajver S, Wicha M, Newman LA, and Ford H. Beyond triple-negative breast cancer and African ancestry: Tumor phenotypes among internationally diverse patient populations J Clin Oncol 2017; 35(15)PMID: Not assigned. Abstract

Jiagge EM, Wong S, Gilani R, McDermott S, Newman L, Bensenhaver J, Wicha M, Carpten J, and Merajver S. Aldh expressing stem cells mediate tumor initiation and metastasis in triple negative breast cancers across different ethnicities Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Kalsi R, Oates CP, Olson S, Drucker CB, Harris DG, Shepard AD, Crawford RS, and Toursavadkohi SS. Lower extremity ischemia, an ominous complication after elective EVAR J Vasc Surg 2017; 66(2):E22-E22. PMID: Not assigned. Abstract

Kamioka N, Babaliaros V, Morse M, Frisoli T, Iturbe JM, Corrigan F, Forcillo J, Caughron H, Dong A, Devireddy C, O'Neill W, Paone G, Dee Wang D, Thourani V, and Greenbaum A. Echocardiographic findings of transcatheter mitral valve-in-valve therapy vs. Re-do surgical MVR in patients with previous mitral prosthetic valves J Am Coll Cardiol 2017; 70(18):B208. PMID: Not assigned. Abstract

Kananeh M, Louchart L, Brady P, Mehta C, Rehman M, Lewis A, Greer D, and Varelas P. Single or dual brain death exams: Tertiary hospital experience over 11 years Neurology 2017; 88(16)PMID: Not assigned. Abstract

Kananeh M, Louchart L, Brady P, Mehta C, Rehman M, Lewis A, Greer D, and Varelas P. Consent rate for organ donation after brain death: A single center experience over 11 years Neurology 2017; 88(16)PMID: Not assigned. Abstract

Kandagatla P, Fisher CJ, Karamanos E, and Gupta AH. Crystalloid resuscitation strategies in patients undergoing emergent bowel resection and anastomosis: When enough is enough J Am Coll Surg 2017; 225(4):S81-S82. PMID: Not assigned. Abstract

Kandagatla P, MacKi M, Hodari-Gupta A, and Rubinfeld I. Unplanned return to the operating room in the neurosurgical population: What drives this dreaded event? J Am Coll Surg 2017; 225(4):S143. PMID: Not assigned. Abstract

Khan J, Rogers T, Schenke W, Greenbaum A, Babaliaros V, Paone G, Ramasawmy R, Chen M, Herzka D, and Lederman R. Transcatheter pledget-assisted suture tricuspid annuloplasty (PASTA) J Am Coll Cardiol 2017; 70(18):B38. PMID: Not assigned. Abstract

Kim J, Myers E, Forbes M, Chetty I, and Glide-Hurst C. SU-G-IeP2-07: Investigation of 3d-printed phantoms for synthetic ct benchmarking in an mr-only workflow Med Phys 2016; 43(6):3657. PMID: 28046242. Abstract

155

Lopez Plaza I, Eisenbrey A, Raoufi M, Yoshida A, and Moonka D. Treating refractory liver allograft rejection with photopheresis Am J Transplant 2017; 17:784. PMID: Not assigned. Abstract

Magliocca J, Markmann J, Abouljoud M, Ghobrial M, and Demetris A. 36 hours of ex-vivo warm cellular perfusion of swine liver using the organ care system (OCS™) liver with excellent functional, metabolic and histological outcomes Am J Transplant 2017; 17:304-305. PMID: Not assigned. Abstract

Markmann J, Ghobrial M, Magliocca J, Demetris A, and Abouljoud M. Results of the initial phase of the portable organ care system (OCS™) liver protect pivotal trial Am J Transplant 2017; 17:305. PMID: Not assigned. Abstract

Masabni K, Balraj P, Liang L, Shepard AD, Nypaver TJ, Weaver MR, and Kabbani L. Cryopreserved allograft in the management of native and prosthetic aortic infections 3 J Am Coll Surg 2017; 225(4):S216. PMID: Not assigned. Abstract

Masabni K, Carlin A, Varban O, Cassidy R, Bonham A, Stricklen A, Finks J, and Ghaferi A. Predictors of one- year follow-up patient survey completion after bariatric surgery Surg Obes Relat Dis 2017; 13(10):S151. PMID: Not assigned. Abstract

Mohammad FH, Kabbani L, Kennedy N, Adas ZA, and Weaver MR. Incidence of endothermal heat-induced thrombosis: Comparison between radiofrequency ablation and laser ablation J Am Coll Surg 2017; 225(4):S217- S218. PMID: Not assigned. Abstract

Mohanty S, Lee JS, Ross RA, Stricklen A, Carlin AM, and Ghaferi AA. New persistent opioid use after bariatric surgery J Am Coll Surg 2017; 225(4):S123. PMID: Not assigned. Abstract

Moonka D, Nagai S, Harper A, and Salgia R. The impact of the donor risk index on tumor free survival in patients undergoing liver transplantation with hepatocellular carcinoma Am J Transplant 2017; 17:433. PMID: Not assigned. Abstract

Moonka D, Salgia R, and Harper AM. The impact of tumor necrosis on tumor free survival in patients undergoing liver transplant with hepatocellular carcinoma: an analysis using the UNOS liver recipient explant pathology form Hepatology 2017; 66:897A-898A. PMID: Not assigned. Abstract

Munie S, Carlin A, Keteyian S, and Kerrigan D. The relationship between reported exercise and medium term weight loss following laparoscopic bariatric surgery Surg Obes Relat Dis 2017; 13(10):S11-S12. PMID: Not assigned. Abstract

Nadeem O, Motwani A, Parikh S, Borgi J, and Hudson M. Acquired left ventricular outflow tract to right atrial fistula due to tricuspid valve endocarditis Am J Respir Crit Care Med 2017; 195PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Brown K, Patel A, Yoshida A, and Abouljuod M. An argument for expanding the simultaneous liver and kidney transplant criteria: Validity of the new UNOS allocation policy Am J Transplant 2017; 17:772-773. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Moonka D, Patel A, Brown K, Yoshida A, and Abouljoud M. Rapid deterioration of pre-transplant kidney function requiring dialysis is a prognostic factor in liver transplant alone Am J Transplant 2017; 17:776. PMID: Not assigned. Abstract

Nagai S, Safwan M, Collins K, Rizzari M, Yoshida A, and Abouljoud M. Incidence and outcomes of immediate post-operative dialysis in liver transplantation Am J Transplant 2017; 17:774. PMID: Not assigned. Abstract

Pahari H, Nagai S, Takahashi K, Tinney F, Denny J, Malinzak L, Rizzari M, Collins K, Yoshida A, Abouljoud M, and Kim D. Risk factors and 2 year outcomes of low estimated glomerular filtration rate in the immediate post- operative period for living kidney donors Am J Transplant 2017; 17:495. PMID: Not assigned. Abstract

Park K, Choi S, Ali H, Divine G, Bensenhaver J, Nathanson D, Proctor E, Petersen L, and Newman L. Clinicopathologic features and models predicting for high-risk 21-gene recurrence score (RS) are unreliable in predicting primary tumor downstaging with neoadjuvant chemotherapy (NACT) Ann Surg Oncol 2017; 24(1):S49- S50. PMID: Not assigned. Abstract

Patel P. Emergency surgery in patients with prior mesh Hernia 2017; 21(1):S63. PMID: Not assigned. Abstract

156 Prashar R, Shah A, Stewart D, Williamson S, and Patel A. Bk polyoma virus and malignancy: Cause or co- incidence? Am J Transplant 2017; 17:483. PMID: Not assigned. Abstract

Putchakayala K, Skorupski S, Farhan S, Chaffins M, Ilias S, Pahari H, Collins K, Nagai S, and Abouljoud M. Graft-versus-host disease following deceased donor liver transplant Am J Transplant 2017; 17:783-784. PMID: Not assigned. Abstract

Saeed H, Rubinfeld I, and Sangha R. Vaginal hysterectomy outcomes; Complications and analysis of risk factors for 30-day readmission J Minim Invasive Gynecol 2017; 24(7):S74-S75. PMID: Not assigned. Abstract

Safwan M, Abouljoud M, and Salgia R. Outcome of liver transplantation in patients with prior bariatric surgery Am J Transplant 2017; 17:580-581. PMID: Not assigned. Abstract

Safwan M, Collins K, Takahashi K, Rizzari M, Yoshida A, Abouljoud M, and Nagai S. Is it safe to use older donor liver grafts for older recipients? Am J Transplant 2017; 17:682. PMID: Not assigned. Abstract

Safwan M, Rizzari M, Collins K, Yoshida A, Skorupski S, Fagoaga O, Abouljoud M, and Nagai S. Effect of preformed donor-specific antibodies in intestine/ multivisceral transplantation Am J Transplant 2017; 17:369. PMID: Not assigned. Abstract

Sangha R, Saeed H, and Rubinfeld I. Analysis of risk factors for readmission after hysterectomy: Use of a national database J Minim Invasive Gynecol 2017; 24(7):S76. PMID: Not assigned. Abstract

Schwarcz TH, and Nypaver TJ. Paneled saphenous vein graft repair of an iliac artery injury in a contaminated abdomen: Late complication of aneurysmal degeneration illustrating the need for continued surveillance J Vasc Surg 2017; 66(2):E38-E39. PMID: Not assigned. Abstract

Stevens H, Stricklen A, Ross R, Carlin A, Alvarez R, and Ghaferi A. Patient perspectives on emergency department self-referral Surg Obes Relat Dis 2017; 13(10):S3-S4. PMID: Not assigned. Abstract

Sulejmani N, Albanna H, Rendulic T, Summers B, and Jantz A. Clinic-based medication education pilot program Am J Transplant 2017; 17:754. PMID: Not assigned. Abstract

Takahashi K, Nagai S, Safwan M, Putchakayala K, Collins K, Rizzari M, Yoshida A, Abouljoud M, and Jafri SM. Lactate level immediate post-liver transplantation is a predictor of early allograft dysfunction Am J Transplant 2017; 17:581. PMID: Not assigned. Abstract

Takahashi K, Nagai S, Safwan M, Putchakayala K, Rizzari M, Collins K, Yoshida A, Schnickel G, and Abouljoud M. Prolonged cold ischemia time as a risk for low regeneration at the early phase after living donor liver transplantation Am J Transplant 2017; 17:587. PMID: Not assigned. Abstract

To L, Jantz A, Hencken L, William C, and Nemeh H. Safety and efficacy of four factor prothrombin complex concentrate for the reversal of warfarin in lvad patients prior to heart transplantation J Heart Lung Transplant 2017; 36(4):S365-S365. PMID: Not assigned. Abstract

Watson JN, Karamanos E, Silverman ME, Kandalaft N, Gupta AH, and Thomas C. Falls, anticoagulation, and the elderly: Are we inappropriately treating atrial fibrillation in this high-risk population? J Am Coll Surg 2017; 225(4):S53. PMID: Not assigned. Abstract

Zaveri H, Surve A, Cottam D, Medlin W, Richards C, and Carlin A. Management of upper gastro-intestinal leaks with endoscopic vaccum-Assisted closure system (e-vac): Two center experience Surg Obes Relat Dis 2017; 13(10):S22. PMID: Not assigned. Abstract

UROLOGY

Abdollah F, Nocera L, Sood A, Dalela D, Karabon P, Rogers C, Peabody J, Briganti A, Montorsi F, and Menon M. Testing the external validity of ProtecT trial results in North American men with clinically localized prostate cancer (PCa) Eur Urol, Supplements 2017; 16(3):e78-e79. PMID: Not assigned. Abstract

Aly AAH, Ahmed Y, Kozlowski J, May P, Nyquist J, Sexton S, Curtin L, Peabody JO, AboulEnein H, and Guru KA. Intracorporeal vs. extracorporeal approaches to W configuration neobladders after robot-assisted radical cystectomy Can Urol Assoc J 2017; 11(9):S316. PMID: Not assigned. Abstract

157 Aly AAH, Ahmed Y, Kozlowski J, Wijburg C, Wiklund P, Hosseini A, Peabody JO, Menon M, Canda A, Richstone L, Wagner A, Kaouk J, Mottrie A, Rha KH, Kelly J, Tan WS, Redorta JP, Khan MS, Kawa O, Gaboradi F, Saar M, Hemal A, Stockle M, Maatman T, and Guru KA. Measuring quality for robot-assisted radical cystectomy worldwide: External validation of the quality cystectomy score utilizing the international robotic cystectomy consortium Can Urol Assoc J 2017; 11(9):S315-S316. PMID: Not assigned. Abstract

Aly AAH, Sexton KJ, Meng MV, Hosseini A, Wiklund P, Eun DD, Daneshmand S, Bochner B, Peabody JO, Abaza R, Skinner EC, Hautmann R, and Guru KA. Development and validation of cystectomy assessment and surgical evaluation (CASE) scoring for male radical cystectomy Can Urol Assoc J 2017; 11(9):S316. PMID: Not assigned. Abstract

Arora S. Robotic excision of a functioning hilar paraganglioma with reconstruction of renal vessels North American Robotic Urology Symposium 2017;PMID: Not assigned. Abstract

Arora S. Robot assisted partial nephrectomy for complex renal hilar tumors: Technical caveats North American Robotic Urology Symposium 2017;PMID: Not assigned. Abstract

Arora S, and Ahlawat R. A novel technique of intrafascial robotic radical prostatectomy with combined anterior- posterior approach to preserve continence mechanism - A Feasibility study North American Robotic Urology Symposium 2017;PMID: Not assigned. Abstract

Dalela D, Sun M, Diaz M, Karabon P, Seisen T, Trinh QD, Menon M, and Abdollah F. Contemporary trends in the incidence of metastatic prostate cancer among us men: Results from nationwide analyses Eur Urol Focus 2017;PMID: Not assigned. Abstract

Dalela D, and Abdollah F. Morbidity and Mortality of Locally Advanced Prostate Cancer: A Population Based Analysis Comparing Radical Prostatectomy versus External Beam Radiation Comment J Urol 2017; 198(5):1067- 1067. PMID: Not assigned. Comment - Abstract

Elshatanoufy S, Griffin M, Wang Y, Jamil M, Matthews A, Yousif M, Richardson D, Atiemo HO, and Luck A. Longterm follow up in patients with mid-urethral slings with BMI greater than 40 Neurourol Urodyn 2017; 36:S147. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Matthews A, Quinn T, Jesse M, Atiemo HO, and Richardson D. Correlation between michigan incontinence severity index and american urolgical society symptom index in female incontinence patients Neurourol Urodyn 2017; 36:S86. PMID: Not assigned. Abstract

Elshatanoufy S, Griffin M, Quinn T, Matthews A, Jesse M, Atiemo HO, and Richardson D. Preliminary exploration: Can suffering and acceptance be found in the discordance between measures? Neurourol Urodyn 2017; 36:S87. PMID: Not assigned. Abstract

ElShatanoufy S, Wang Y, Matthews A, Jamil ML, Yousif M, Gutta S, Gill H, and Luck A. Effect of morbid obesity on mid-urethral sling effecacy for the management of stress urinary incontinence Female Pelvic Med Reconstr Surg 2017; 23(5):S41. PMID: Not assigned. Abstract

Gild P, and Abdollah F. Oncologic and functional outcomes after radical prostatectomy for high or very high risk prostate cancer: European validation of the current nccn (r) guideline editorial comment J Urol 2017; 198(2):361-361. PMID: Not assigned. Abstract

Gild P, Von Landenberg N, Sun M, Develasco G, Brastianos P, Menon M, Fisch M, Chun F, Nguyen P, Trinh QD, and Choueiri T. Contemporary incidence and epidemiologic trends of brain metastases at renal cell carcinoma diagnosis Eur Urol, Supplements 2017; 16(3):e1121-e1122. PMID: Not assigned. Abstract

Hanna N, Trinh QD, Sammon J, Seisen T, Vetterlein M, Moreira R, Preston M, Lipsitz S, Bellmunt J, Menon M, Choueiri T, and Abdollah F. Is neoadjuvant chemotherapy beneficial before radical cystectomy? Examining the external validity of the SWOG-8710 trial Eur Urol, Supplements 2017; 16(3):e295. PMID: Not assigned. Abstract

Jamal M, Brown R, Inamdar KV, Gomez-Gelvez J, Carey JL, and Menon MP. Evaluation of flow cytometric variables in mycosis fungoides blood staging Lab Invest 2017; 97:356A-356A. PMID: Not assigned. Abstract

Jebastin JAS, Gupta NS, Carskadon S, Palanisamy N, and Williamson SR. Pseudosarcomatous myofibroblastic proliferations of the urinary bladder lack the usp6 gene rearrangement common in nodular fasciitis Lab Invest 2017; 97:233A-233A. PMID: Not assigned. Abstract

158 Jindal T, Dalela D, Karabon P, Vetterlein M, Seisen T, Sood A, Trinh QD, Jeong W, Menon M, and Abdollah F. Survival associated with radical prostatectomy versus radiotherapy for high-risk prostate cancer: A contemporary, nationwide observational analysis Eur Urol, Supplements 2017; 16(3):e40. PMID: Not assigned. Abstract

Kachroo N, Irish V, and Atiemo HO. Effectiveness of sacral neuromodulation in the treatment of non-obstructive urinary retention in women with subacute lower lumbar injury Neurourol Urodyn 2017; 36:S101. PMID: Not assigned. Abstract

Löppenberg B, Sood A, Dalela D, Karabon P, Sammon J, Vetterlein M, Noldus J, Peabody J, Trinh QD, Menon M, and Abdollah F. Variation in prostate cancer care at commission on cancer designated facilities Eur Urol, Supplements 2017; 16(3):e1393-e1394. PMID: Not assigned. Abstract

Meyer C, Gild P, Von Landenberg N, Friedlander D, Eswara J, Menon M, Chun F, Fisch M, Sun M, Chung B, Chang S, and Trinh QD. Comparative effectiveness of transurethral resection techniques for benign prostatic hyperplasia - analysis of an all payer in patient discharge database Eur Urol, Supplements 2017; 16(3):e308-e309. PMID: Not assigned. Abstract

Pucheril DT, Elshatanoufy S, Irish V, Diaz M, and Atiemo HO. Does ureaplasma urealyticum have an active role in female lower urinary tract symptoms? Neurourol Urodyn 2017; 36:S63-S64. PMID: Not assigned. Abstract

Pucheril DT, Karabon P, Trinh QD, Chughtai BI, and Atiemo HO. Antimuscarinic use in the elderly: A poisoned apple? Neurourol Urodyn 2017; 36:S150-S151. PMID: Not assigned. Abstract

Seisen T, Briganti A, Blanchard P, and Abdollah F. Salvage radiation therapy for biochemical recurrence after radical prostatectomy: Is earlier always better? J Clin Oncol 2017; 35(13):1489-+. PMID: Not assigned. Abstract

Seisen T, Sonpavde G, Kachroo N, Lipsitz S, Leow J, Menon M, Gild P, Von Landenberg N, Rouprêt M, Kibel A, Sun M, Pal S, Bellmunt J, Choueiri T, and Trinh QD. Comparative effectiveness of selective adjuvant versus systematic neoadjuvant chemotherapy-based strategy for muscle-invasive urothelial carcinoma of the bladder Eur Urol, Supplements 2017; 16(3):e291-e292. PMID: Not assigned. Abstract

Seisen T, Sun M, Lipsitz S, Abdollah F, Leow J, Menon M, Von Landenberg N, Gild P, Rouprêt M, Preston M, Harshman L, Kibel AS, Nguyen P, Bellmunt J, Choueiri T, and Trinh QD. Comparative effectiveness of trimodal therapy versus radical cystectomy for localized muscle-invasive urothelial carcinoma of the bladder Eur Urol, Supplements 2017; 16(3):e476-e478. PMID: Not assigned. Abstract

Tashakori M, Sanchez J, Michalowski SM, Louissaint A, Inamdar KV, Gomez-Gelvez J, Carey JL, and Menon MP. Follicular lymphoma transforming to double and triple hit lymphoma; a clinicopathologic, morphologic and cytogenetic analysis Lab Invest 2017; 97:380A-381A. PMID: Not assigned. Abstract

Thamilselvan V, Menon M, and Thamilselvan S. In vitro and in vivo effect of carmustine and selenite combination on EGFR signaling in androgen-independent prostate cancer Cancer Research 2017; 77(13)PMID: Not assigned. Abstract

Wang L, Harms PW, Palanisamy N, Carskadon S, Cao X, Siddiqui J, Patel RM, Zelenka-Wang S, Johnson TM, Durham A, Su F, Shukla S, Mehra R, and Chinnaiyan AM. A novel RNA in situ hybridization approach highly sensitive for detection of Merkel cell polyomavirus Cancer Res 2017; 77(13)PMID: Not assigned. Abstract

Williamson SR, and Palanisamy N. Monosomy 8 as a Surrogate for TCEB1 Mutation in Renal Cell Tumors with Prominent Stroma Lab Invest 2017; 97:267A-268A. PMID: Not assigned. Abstract

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