2017 RESEARCH ANNUAL REPORT TABLE OF CONTENTS SUMMARIES OF 2017 NATIONAL INSTITUTES OF HEALTH AND OTHER FEDERAL GRANTS AWARDED TO HFHS PART I – INTERNAL MEDICINE DEPARTMENT_________________________________ ALLERGY AND IMMUNOLOGY ................................................................................................. 1 CARDIOLOGY/CARDIOVASCULAR RESEARCH…………………………………………….1 ENDOCRINOLOGY AND METABOLISM .................................................................................. 2 GASTROENTEROLOGY ............................................................................................................. .3 HEMATOLOGY/ONCOLOGY…………………………………………………………………...4 HYPERTENSION AND VASCULAR RESEARCH……………………………………………...5 INFECTIOUS DISEASE…………………………………………………………………………..9 PULMONARY……………………………………………………………………………………10 SLEEP MEDICINE ....................................................................................................................... 11 GENERAL INTERNAL MEDICINE…………………………………………………………….13 PART II – ALL OTHER CLINICAL DEPARTMENTS_______________________________ DERMATOLOGY ........................................................................................................................ 14 NEUROLOGY .............................................................................................................................. 15 NEUROSURGERY……………………………………………………………………………….23 ORTHOPAEDICS/BONE & JOINT……………………………………………………………..24 PATHOLOGY ............................................................................................................................... 25 RADIATION ONCOLOGY .......................................................................................................... 26 PART III POPULATION SCIENCES______________________________________________ CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ............................. 28 DEPARTMENT OF PUBLIC HEALTH SCIENCES ................................................................... .33 i PUBLICATIONS ADMINISTRATION……………………………………………………………………………..46 ANESTHESIOLOGY ................................................................................................................... 46 BEHAVIORAL HEALTH SERVICES/PSYCHIATRY................................................................46 Neuropsychology……………………………………………………………………………...47 CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ............................. 47 CLINICAL QUALITY AND SAFETY…………………………………………………………..49 DERMATOLOGY ......................................................................................................................... 49 DIAGNOSTIC RADIOLOGY…………………………………………………………………....53 EMERGENCY MEDICINE .......................................................................................................... 55 FAMILY MEDICINE…………………………………………………………………………….56 GLOBAL HEALTH INITIATIVE ................................................................................................ 57 GRADUATE MEDICAL EDUCATION………………………………………………………...57 INTERNAL MEDICINE Allergy and Immunology……………………………………………………………………..57 Cardiology/Cardiovascular Research…………………………………………………………58 Endocrinology and Metabolism……………………………………………………………….63 Gastroenterology………………………………………………………………………………65 Hematology-Oncology………………………………………………………………………..66 Hypertension and Vascular Research ....................................................................................... 68 Infectious Diseases……………………………………………………………………………69 Nephrology……………………………………………………………………………………70 Pulmonary and Critical Care Medicine .................................................................................... 71 Rheumatology…………………………………………………………………………………72 ii Sleep Medicine…………………………………………………………………………….….72 General Internal Medicine/Palliative Medicine/Hospitalist/Other……………………………73 NEUROLOGY ............................................................................................................................. 74 NEUROSURGERY ..................................................................................................................... .79 NURSING………………………………………………………………………………………..82 OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES………………........82 OPTHALMOLOGY AND EYE CARE SERVICES…………………………………………….83 ORTHOPAEDICS/BONE AND JOINT……………………………………………………...….83 OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...................................................... ..86 PATHOLOGY ............................................................................................................................. ..87 PEDIATRICS.................................................................................................................................89 PHARMACY…………………………………………………………………………………….89 PUBLIC HEALTH SCIENCES .................................................................................................. .90 RADIATION ONCOLOGY……………………………………………………………………..95 RESEARCH ADMINISTRATION Image Analysis Program……………………………………………………………………...98 Genetics Research…………………………………………………………………………….99 SURGERY…………………………………………………………………………………….....99 Plastic Surgery…………………………………………………………………………….…102 UROLOGY……………………………………………………………………………………...102 iii ABSTRACTS ANESTHESIOLOGY ................................................................................................................. 106 BEHAVIORAL HEALTH SERVICES………………………………………………………...107 Psychology/Neuropsychology……………………………………………………………….107 CENTER FOR HEALTH POLICY AND HEALTH SERVICES RESEARCH ......................... 107 CLINICAL QUALITY AND SAFETY………………………………………………………...108 COMMUNITY HEALTH EQUITY AND WELLNESS……………………………………….108 DERMATOLOGY………………………………………………………………………………108 DIAGNOSTIC RADIOLOGY .................................................................................................... 111 EMERGENCY MEDICINE ........................................................................................................113 FAMILY MEDICINE…………………………………………………………………………..115 GLOBAL HEALTH INITIATIVE .............................................................................................. 115 INTERNAL MEDICINE Allergy and Immunology…………………………………………………………………….115 Cardiology/Cardiovascular Research………………………………………………………...115 Endocrinology and Metabolism……………………………………………………………...120 Gastroenterology……………………………………………………………………………..121 Hematology-Oncology……………………………………………………………………….123 Hypertension and Vascular Research………………………………………………………...125 Infectious Disease……………………………………………………………………………126 Nephrology…………………………………………………………………………………...126 Pulmonary and Critical Care Medicine………………………………………………………127 Rheumatology………………………………………………………………………………..129 Sleep Medicine……………………………………………………………………………….129 General Internal Medicine/Palliative Medicine/Hospitalist/Other…………………………..129 iv NEUROLOGY ............................................................................................................................ 130 NEUROSURGERY ..................................................................................................................... 134 OBSTETRICS, GYNECOLOGY AND WOMEN’S HEALTH SERVICES .............................. 137 Urogynecology……………………………………………………………………………….138 OPHTHALMOLOGY AND EYE CARE SERVICES ................................................................ 139 ORTHOPAEDICS/BONE & JOINT AND ATHLETIC MEDICINE ........................................ 139 OTOLARYNGOLOGY – HEAD AND NECK SURGERY ...................................................... 140 PATHOLOGY ............................................................................................................................ 140 PHARMACY ............................................................................................................................... 142 PUBLIC HEALTH SCIENCES .................................................................................................. 142 RADIATION ONCOLOGY ....................................................................................................... 147 RESEARCH ADMINISTRATION Cytogenetics .......................................................................................................................... 153 Image Analysis Program…………………………………………………………………….153 SURGERY ..................................................................................................................................154 UROLOGY ................................................................................................................................ 157 v Summaries of 2017 National Institutes of Health and other Federal Grants Awarded to HFHS Part I –Department of Internal Medicine • Allergy and Immunology • Cardiology/Cardiovascular Research • Endocrinology and Metabolism • Gastroenterology • Hematology/Oncology • Hypertension and Vascular Research • Infectious Disease • Pulmonary • Sleep Medicine • General Internal Medicine Allergy and Immunology Principal Investigator: Edward Zoratti, M.D. ICAC 3 - Inner City Asthma Consortium Infrastructure (UM1AI114271) Subcontract The objectives of the Inner City Asthma Consortium are to implement a long range scientific plan to reduce asthma severity and prevent asthma among inner city children and to identify the mechanisms involved in the immunopathogenesis of asthma in these populations. The specific objectives are to: 1) conduct clinical trials to evaluate the safety and efficacy of promising immune based therapies in reducing asthma severity and preventing disease onset in minority children residing in inner cities in the