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11. Stambolic V et al: Negative regulation of PKB/Akt- Chapter 119 dependent cell survival by the tumor suppressor Appendage Tumors PTEN. Cell 95:29, 1998 12. Ponti G et al: Value of MLH1 and MSH2 mutations and Hamartomas of in the appearance of Muir-Torre syndrome phe- notype in HNPCC patients presenting sebaceous the Skin gland tumors or keratoacanthomas. J Invest Dermatol 126:2302-2307, 2006 Divya Srivastava & R. Stan Taylor 13. Thiboutot D: Regulation of human sebaceous glands. J Invest Dermatol 123:1-12, 2004 14. James WD, Berger TG, Elston DM: Andrews’ Dis- eases of the Skin: Clinical Dermatology. Philadel- phia, Elsevier Health Sciences, 2005 15. Troy JL, Ackerman AB. Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differen- tiating toward sebaceous cells. Am J Dermatopa- REFERENCES thol 6:7-13, 1984 16. Jadassohn J. Bemerkuger zur histologieder sys- tematisirten naevi and ueber “Talgdrusen-navi”. 1. Requena L et al: Neoplasms with Apocrine Differ- Arch Derm Syphilol 33:355-394, 1895 entiation. Philadelphia, Lippincott-Raven, Ardor 17. Carlson JA et al: Epidermodysplasia verruciformis- Scribendi, 1997 associated and genital-mucosal high-risk human 2. Steffen C, Ackerman AB: Neoplasms with Se- papillomavirus DNA are prevalent in nevus seba- baceous Differentiation. Philadelphia, Lea and ceus of Jadassohn. J Am Acad Dermatol 59:279-94, Febiger, 1994 2008 3. Ackerman AB et al: Neoplasms with Follicular Dif- 18. Happle R, Konig A: Familial nevus sebaceus may ferentiation. New York, Ardor Scribendi, 2001 be explained by paradominant transmission. Br J Dermatol 141:377, 1999 4. Ahmed TS, Del Priore J, Seykora J: Tumors of the Epidermal Appendages in Lever’s Histopathology, 19. Xin H et al: The sebaceous nevus: A nevus 10th ed., edited by DE Elder, R Elenitsas, B John- with deletions of the PTCH gene. Cancer Res son, G Murphy, G Xu. Philadelphia, Lippincott, 59(8):1834-1836, 1999 Williams, and Wilkins, 2009 20. Jacqueti G, Requena L, Sanchex Yus E: Trichoblas- 5. Alsaad KO, Obaidat NA, Ghazarian D: Skin adnexal toma is the most common neoplasm developed neoplasms—Part 1: An approach to tumors of in nevus sebaceus of Jadassohn: A clinicopatho- the pilosebaceous unit. J Clin Pathol 60:129-144, logic study of a case series of 155 cases. Am J 2007 Dermatopathol 22:108-118, 2000 6. Obaidat NA, Alsaad KO, Ghazarian D: Skin adnexal 21. Eisen DB, Michael DJ: Sebaceous lesions and their neoplasms—Part 2: An approach to tumors of associated syndromes: Part I. J Am Acad Dermatol cutaneous sweat glands. J Clin Pathol 60:145-159, 61(4):549-560 2007 22. Mehregan AH, Pinkus H: Life history of organoid 7. Storm CA, Seykora JT: Cutaneous adnexal neo- nevi: Special reference to nevus sebaceous of plasms. Am J Clin Pathol 118(Suppl. 1):S33-S49, jadassohn. Arch Dermatol 91:574-588, 1965 2002 23. Cribier B, Scrivener Y, Grosshans E: Tumors arising 8. McCalmont TH: A call for logic in the classifica- in nevus sebaceous: A study of 596 cases. J Am tion of adnexal neoplasms. Am J Dermatopathol Acad Dermatol 42:63-68, 2000 18(2):111, 1996 24. Ball EAM, Hussain M, Moss ALH: Squamous cell 9. Biernat W et al: p53 mutations in sweat gland carcinoma and basal cell carcinoma arising in a carcinomas. Int J Cancer 76:317, 1998 nevus sebaceus of Jadassohn: Case report and literature review. Clin Exp Dermatol 30:259-260, 10. Aszterbaum M et al: Ultraviolet and ionizing 2005 radiation enhance the growth of BCCs and tricho- blastomas in patched heterozygous knockout 25. Wilson JE, Heyl T: Nevus sebaceus. Br J Dermatol mice. Nat Med 5:1285, 1999 82:99, 1970 696 Chapter 119: Appendage Tumors and Hamartomas of the Skin 26. Eisen DB, Michael DJ: Sebaceous lesions and their 43. Sawyer AR et al: Should extraocular sebaceous associated syndromes: Part II. J Am Acad Dermatol carcinoma be investigated using sentinel node 61(4):563-578, 2009 biopsy. Dermatol Surg 35(4):704-708, 2009 27. Ashinoff R: Linear nevus sebaceus of Jadassohn 44. Omura NE et al: Sebaceous carcinoma in children. treated with the carbon dioxide laser. Pediatr J Am Acad Dermatol 47(6):950-953, 2002 Dermatol 10:189-191, 1993 45. Dasgupta T, Wilson LD, Yu JB: A Retrospective 28. Kovich O, Hale EK: Nevus sebaceus. Dermatol review of 1349 cases of sebaceous carcinoma. Online J 11:16, 2005 Cancer 115(1):158-165, 2009 29. Dierickx CC et al: Photodynamic therapy for 46. Snow SN et al: Sebaceous carcinoma of the nevus sebaceus with topical delta-aminolevulinic eyelids treated by Mohs micrographic surgery: acid. Arch Dermatol 135:637-640, 1999 Report of nine cases with review of the literature. Dermatol Surg 28:623-631, 2002 30. Kumar P, Barton SP, Marks R: Tissue measure- ments in senile sebaceous gland hyperplasia. Br J 47. Bailet JW et al: Sebaceous carcinoma of the Dermatol 118:397-402, 1988 head and neck. Arch Otolaryngol Head Neck Surg 118(11):1245-1249 31. Salim A et al: Sebaceous hyperplasia and skin cancer in patients undergoing renal transplant. J 48. Harrington CR, Egbert BM, Swetter SM: Extraocu- Am Acad Dermatol 55:878-881, 2006 lar sebaceous carcinoma in a patient with Muir- Torre syndrome. Dermatol Surg 30:817-819, 2004 32. Boschnakow A et al: Ciclosporin A-induced seba- ceous gland hyperplasia. Br J Dermatol 149:198- 49. Reina RS, Parry E: Aggressive extraocular seba- 200, 2003 ceous carcinoma in a 52-year-old man. Dermatol Surg 32:1283-86, 2006 33. Richey DF: Aminolevulinic acid photodynamic therapy for sebaceous gland hyperplasia. Derma- 50. Muir EG, Bell AJY, Barlow KA: Multiple primary tol Clin 25:59-65, 2007 carcinomata of the colon, duodenum, and larynx associated with keratoacanthomata of the face. 34. Ma HJ, Zhao G, Wang YX: Sebaceous hyperplasia Br J Surg 54:191-195, 1967 of the scrotum in an adolescent boy. Pediatr Dermatol 24:340-342, 2007 51. Torre D: Multiple sebaceous tumors. Arch Derma- tol 98:549-551, 1968 35. Al-Daraji WI et al: Sebaceous hyperplasia of the vulva: A clinicopathological case report with a 52. Mangold E et al: A genotype-phenotype cor- review of the literature. J Clin Pathol 60:835-837, relation in HNPCC: A strong predominance of 2007 MSH2 mutations in 41 patients with Muir-Torre syndrome. J Med Genet 41:567-571, 2004 36. Woldow AB, Houk LD, Samie F: Juxtaclavicular beaded lines: A presentation of sebaceous hyper- 53. Hampel H et al: Cancer risk on hereditary nonpol- plasia. Dermatol Online J 15(4):14, 2009 yposis colorectal cancer syndrome: Later age of onset. Gastroenterology 129:415-421, 2005 37. Davis TT, Calilao G, Fretzin D: Sebaceous hyper- plasia overlying a dermatofibroma. Am J Derma- 54. Archer-Dubon C et al: Immunohistochemistry topathol 28:155-157, 2006 screening of sebaceous lesions for Muir Torre syndrome in a 26 year period in a Mexican popu- 38. Choi MJ, Kim JW, Koh BK: Solitary premature lation. Dermatol Online J 14(12):1, 2008 sebaceous hyperplasia associated with acneiform eruption. Acta Derm Venereol 84:483-484, 2004 55. Khashayar A, Khachemoune A: Hidrocystomas— A brief review. Med Gen Med 8(3):57, 2006 39. Zaballos P et al: Dermoscopy of sebaceous hyper- plasia. Arch Dermatol 141:808, 2005 56. Anzai S et al: Apocrine Hidrocystoma: A case report and analysis of 167 Japanese cases. Int J 40. Abbas O, Mahalingam M: Cutaneous sebaceous Dermatol 44:702-703, 2005 neoplasms as markers of Muir-Torre syndrome: A diagnostic algorithm. J Cutan Pathol 36:613-619, 57. Holder WR, Smith JD, Mocega EE: Giant apocrine 2009 hidrocystoma. Arch Dermatol 104:522-523, 1971 41. Lever WF: Sebaceous Adenoma. Arch Derm Syphi- 58. Alessi E, Gianotti R, Coggi: Multiple apocrine lol 57(1):102-111, 1948 hidrocystomas of the eyelids. Br J Dermatol 137:642-645, 1997 42. Rulon DB, Helwig EB: Cutaneous sebaceous neo- plasms. Cancer 33:82-102, 1974 59. Malliah U, Dickinson J: Multiple bilateral eyelid apocrine hidrocystomas and ectodermal dyspla- sia. Arch Opthalmol 119:1866, 2001 Copyright© McGraw-Hill Companies, Inc. All rights reserved. Chapter 119: Appendage Tumors and Hamartomas of the Skin 697 60. Blugerman G et al: Multiple eccrine hidrocysto- 76. Helwig EB, Hackney VC: Syringocystadenoma mas: A new therapeutic options with botulinum papilliferum. Arch Dermatol 71:361, 1955 toxin. Dermatol Surg 29:557, 2003 77. Karg E et al: Congenital syringocystadenoma pap- 61. Del Pozo J et al: Multiple apocrine hidrocystomas: illiferum. Pediatr Dermatol 25(1):132-133, 2008 Treatment with carbon dioxide laser evaporation. 78. Mammino JJ, Vidmar DA: Syringocystadenoma J Dermatol Treat 12:97, 2001 papilliferum. Int J Dermatol 30:763-766, 1991 62. Gupta S et al: The efficacy of electrosurgery and 79. Boni R et al: Syringocystadenoma papilliferum: A excision in treating patients with multiple apo- study of potential tumor suppressor genes. Am J crine hidrocystomas. Dermatol Surg 27:382, 2001 Dermatopathol 23(2):87-89, 2001 63. Tansi E, Alster TS: Pulsed dye laser treatment 80. Philipone E, Chen S: Unique case: Syringocystad- of multiple eccrine hidrocystomas: A novel ap- enoma papilliferum associated with an eccrine proach. Dermatol Surg 27:898, 2001 nevus. Am J Dermatopathol. 31(8):806-807, 2009 64. Vakilzadeh F et al: Fokale dermal hypoplaise mi 81. Schaffer JV et al: Syringocystadenoma papil- apokrinen naeivi and streifenfoermiger anomalie liferum in a patient with focal dermal hypoplasia der knochen. Arch Dermatol 256:189, 1976 due to a novel PORCN mutation. Arch Dermatol 65. Liu HM et al: Facial apocrine fibroadenoma 145(2):218-219, 2009 in man: A rare finding. Am J Dermatopathol 82. Chi CC, Tsai RY, Wang SH: Syringocystadenocarci- 29(3):274-278, 2007 noma papillferum successfully treated with Mohs 66.
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  • Rippled-Pattern Sebaceoma: a Report of a Lesion on the Back with a Review of the Literature

    Rippled-Pattern Sebaceoma: a Report of a Lesion on the Back with a Review of the Literature

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Fukui Repository Rippled-pattern sebaceoma: A report of a lesion on the back with a review of the literature Takahiro Kiyohara, M.D., Masanobu Kumakiri, M.D., Hiroaki Kuwahara, M.D., Atsuko Saitoh, M.D., and Shinichi Ansai, M.D. Department of Dermatology (T.K., M.K.), University of Fukui, Fukui; Division of Plastic Surgery (H.K.), Obihiro-Kousei General Hospital, Obihiro: Sapporo Institute for Dermatopathology (S.A.), Sapporo, Japan Address correspondence and reprint requests to: Takahiro Kiyohara, M.D. Department of Dermatology, University of Fukui 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan Tel: +81 776 61 3111 Fax: +81 776 61 8112 e-mail: kiyo @ fmsrsa.fukui-med.ac.jp Abstract A 68-year-old Japanese man presented with a tumor that had been present for 5 to 6 years on the right back. Physical examination revealed a dome-shaped, 12x13-mm, dark red tumor. The tumor was excised with a 2 to 3-mm margin. The patient has remained free of disease during 77-months of follow-up. Microscopic examination revealed a bulb-like tumor in the dermis, contiguous with the overlying epidermis. It was composed of small, monomorphous, cigar-shaped basaloid cells in linear, parallel rows, resembling the palisading of nuclei of Verocay bodies, and presenting a rippled-pattern. There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei. There were tiny, duct-like spaces. The tumor revealed characteristics of rippled-pattern sebaceoma.
  • Nevus Sebaceus with Syringocystadenoma

    Nevus Sebaceus with Syringocystadenoma

    UC Davis Dermatology Online Journal Title Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions Permalink https://escholarship.org/uc/item/85k968bk Journal Dermatology Online Journal, 26(2) Authors Basu, Pallavi Erickson, Christof P Calame, Antoanella et al. Publication Date 2020 DOI 10.5070/D3262047411 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 26 Number 2| February 2020| Dermatology Online Journal || Case Report 26(2):5 Nevus sebaceus with syringocystadenoma papilliferum, prurigo nodularis, apocrine cystadenoma, basaloid follicular proliferation, and sebaceoma: case report and review of nevus sebaceus-associated conditions Pallavi Basu1 MPH, Christof P Erickson2 MD, Antoanella Calame2 MD, and Philip R Cohen3,4 MD Affiliations: 1School of Medicine, University of California San Diego, La Jolla, California, USA, 2Compass Dermatopathology, San Diego, California, USA, 3San Diego Family Dermatology, National City, California, USA, 4Touro California College of Osteopathic Medicine, Vallejo, California, USA Corresponding Authors: Pallavi Basu, MPH, 8528 Via Mallorca, Apartment G, La Jolla, CA 92037, Tel: 818-917-1786, Email: [email protected]; Philip R. Cohen MD, 10991 Twinleaf Court, San Diego, CA 92131, Email: [email protected] with nevus sebaceus who not only developed Abstract syringocystadenoma papilliferum but also prurigo Nevus sebaceus is a benign skin hamartoma of nodularis in the inferior portion of her lesion is congenital onset that grows during puberty, and in described. Complete excision of the residual nevus adulthood can develop secondary benign and sebaceus also revealed three concurrent additional malignant neoplasms.
  • 2016 Essentials of Dermatopathology Slide Library Handout Book

    2016 Essentials of Dermatopathology Slide Library Handout Book

    2016 Essentials of Dermatopathology Slide Library Handout Book April 8-10, 2016 JW Marriott Houston Downtown Houston, TX USA CASE #01 -- SLIDE #01 Diagnosis: Nodular fasciitis Case Summary: 12 year old male with a rapidly growing temple mass. Present for 4 weeks. Nodular fasciitis is a self-limited pseudosarcomatous proliferation that may cause clinical alarm due to its rapid growth. It is most common in young adults but occurs across a wide age range. This lesion is typically 3-5 cm and composed of bland fibroblasts and myofibroblasts without significant cytologic atypia arranged in a loose storiform pattern with areas of extravasated red blood cells. Mitoses may be numerous, but atypical mitotic figures are absent. Nodular fasciitis is a benign process, and recurrence is very rare (1%). Recent work has shown that the MYH9-USP6 gene fusion is present in approximately 90% of cases, and molecular techniques to show USP6 gene rearrangement may be a helpful ancillary tool in difficult cases or on small biopsy samples. Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors, 5th edition. Mosby Elsevier. 2008. Erickson-Johnson MR, Chou MM, Evers BR, Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X, Oliveira AM. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011 Oct;91(10):1427-33. Amary MF, Ye H, Berisha F, Tirabosco R, Presneau N, Flanagan AM. Detection of USP6 gene rearrangement in nodular fasciitis: an important diagnostic tool. Virchows Arch. 2013 Jul;463(1):97-8. CONTRIBUTED BY KAREN FRITCHIE, MD 1 CASE #02 -- SLIDE #02 Diagnosis: Cellular fibrous histiocytoma Case Summary: 12 year old female with wrist mass.