DOCSLIB.ORG

Biomarkers in Sebaceous Gland Carcinomas

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Biomarkers in Sebaceous Gland Carcinomas 3/24/2017 Biomarkers in Sebaceous Gland Carcinomas Sander R. Dubovy, MD Professor of Ophthalmology and Pathology Victor T. Curtin Chair in Ophthalmology Florida Lions Ocular Pathology Laboratory Bascom Palmer Eye Institute University of Miami Miller School of Medicine Biomarkers in Sebaceous Gland Carcinomas Disclosure of Relevant Disclosure of Relevant Financial Relationships Financial Relationships USCAP requires that all planners (Education Committee) in a position to Dr. Sander R. Dubovy declares he has no conflict(s) of interest influence or control the content of CME disclose any relevant financial to disclose. relationship WITH COMMERCIAL INTERESTS which they or their spouse/partner have, or have had, within the past 12 months, which relates to the content of this educational activity and creates a conflict of interest. Biomarkers in Sebaceous Gland Carcinomas Outline Introduction • Sebaceous carcinoma (SC) is a malignant neoplasm that arises from • Introduction to sebaceous cell carcinoma the sebaceous glands, most commonly in the periocular areas. • Incidence, demographics, risk factors • Clinical manifestations are often mistaken for benign conditions and • Ocular origins thus proper diagnosis and management is delayed. • Gross pathology • Metastases to regional lymph nodes and other sites are common. • Microscopic pathology • Immunohistochemistry • Management • Cases Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas 1 3/24/2017 Introduction Sebaceous Gland • Pathologists should be aware of the varied clinical • Composed of two types of cells: manifestations, histopathological morphology and • Peripheral basophilic cells various biomarkers used for accurate diagnosis. • Sebocytes: Central foamy/vacuolated cytoplasm • Overview of the most important factors in periocular sebaceous carcinomas and biomarkers. Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas Definitions Extraorbital primary locations • Sebaceous carcinoma (sebaceous gland carcinoma, • 75% of the cases arise in the ocular adnexae. sebaceous cell carcinoma) is a malignant neoplasm that • Approximately 25% of sebaceous carcinomas arise from an arises from the sebaceous glands. extraocular region • Parotid gland is the most common location. • Glands in these areas are named: • Meibomian glands (eyelid) • These tumors arise from two possible cells: pluripotent cells with • Zeis glands (cilia) capacity for sebaceous differentiation or from ectopic sebaceous cells that developed during embryogenesis • Sebocytes: • Foamy cells within the gland • Produce sebum to regulate tear evaporation • Precursor cell of sebaceous carcinoma Shields JA, Demirci H, Marr BP, Eagle RC, Shields CL. Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol. Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas 2005;50(2):103 -22. Extraorbital primary locations Incidence • Other reported locations include: • Periocular skin neoplasms account for 5-10% of all skin • submandibular glands malignancies in the United States. • extremities • Basal cell carcinoma - 90% of malignant eyelid tumors • toes • Sebaceous cell carcinoma - 5% of eyelid tumors • penis • Squamous cell carcinoma - 4% of eyelid tumors • chest • Melanoma - 1% of eyelid tumors • sole of foot • external auditory canal • ear • anterior neck region • Wide variety of anatomical locations of this neoplasm. Ghosh, Sudip Kumar; Bandyopadhyay, Debabrata; Gupta, Sandipan; Chatterjee, Gobinda; & Ghosh, Arghyaprasun. (2008). Rapidly growing extraocular sebaceous carcinoma occurring during pregnancy: A case report. Dermatology Online Journal, 14(8). Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas 2 3/24/2017 Incidence Demographics and Risk Factors • Incidence of sebaceous carcinoma is 0.5/million in the Caucasian population older than 20-years-old in the US. • Reports from China, India and other Asian countries indicate incidence of 31.2% - 39% of eyelid malignancies • Age: Mean age at diagnosis has ranged from 57 years to 72 years. • Sung details a case of one of the youngest patient on the literature to develop sebaceous carcinoma without syndromic disease at age 32. • Sex: Approximately 70% of the sebaceous carcinomas occur in females. Biomarkers in Sebaceous Gland Carcinomas Mulay K, Aggarwal E, White VA. Periocular sebaceous gland carcinoma: A Biomarkers in Sebaceous Gland Carcinomas comprehensive review. Saudi J Ophthalmol. 2013;27(3):159-65. Demographics and Risk Factors • Irradiation: Several reports of patients with prior history of irradiation due to hereditary retinoblastoma treatment, acne, cutaneous hemangioma and eczema. • Rundle details a case in which a patient developed sebaceous gland carcinoma after being subject to irradiation for bilateral retinoblastoma. • The carcinogenic effects of irradiation are well documented. • The irradiation could affect the remaining RB gene and thus predispose the patient for secondary malignancies. • Osteosarcoma • Cutaneous melanoma • Sebaceous gland carcinoma Biomarkers in Sebaceous Glandhttps://www.cancer.gov/types/retinoblastoma/patient/retinoblastoma-treatment-pdq Carcinomas Biomarkers in Sebaceous Gland Carcinomas http://iopscience.iop.org/article/10.1088/0031-9155/57/22/7741 Ocular origins • Meibomian glands: Most common origin • Upper eyelid is affected in 75% • Lower eyelid 22% • Conjunctiva 2% • Caruncle 2% • Retrospective study of 104 cases of sebaceous carcinoma of the ocular adnexa with at least 5 years’ follow-up • Various clinicopathologic features that indicate poor prognosis were identified http://www.pathologyoutlines.com/topic/eyeeyelidanatomy.html Biomarkers in Sebaceous GlandShields JA, Carcinomas et al. Sebaceous Carcinoma of the Eyelids: Personal Experience with 60 Cases. Ophthalmology 2004;111:2151-2157. Biomarkers in Sebaceous Gland Carcinomas 3 3/24/2017 Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas Ocular origins • Zeis glands: Glands associated with cilia: 10% of SC of the eyelid. • Caruncle: 5-10% of all SC (abundant sebaceous glands). • Conjunctiva: SC of the conjunctiva with no involvement of the nearby skin structures (rare). Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas Clinical Features • Commonly can masquerade as a benign condition, Clinical Presentation blepharitis/chalazion (“masquerade syndrome”) • Resulting in a delay in diagnosis. • Solitary nodule • Increases the chance of local recurrence, metastasis, and death. • Diffuse pseudoinflammatory pattern • Pedunculated lesion • Caruncular mass Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas 4 3/24/2017 Clinical Features • Solitary eyelid nodule: Most common clinical Clinical Presentation manifestation • Painless, firm, sessile to round, subcutaneous • Solitary nodule nodule in the eyelid. • Yellow color due to the presence of lipid. • Loss of cilia (madarosis). • Diffuse pseudoinflammatory pattern • Pedunculated lesion • Caruncular mass Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas Clinical Features • Diffuse pseudo-inflammatory pattern: The second most Clinical Presentation common presentation. • Diffuse unilateral thickening of the eyelid. • Solitary nodule • Most likely to extend to the epithelium • SC must be ruled out in an older patient with unilateral blepharitis that does not respond to standard treatment. • Diffuse pseudoinflammatory pattern • Pedunculated lesion • Caruncular mass Case initially diagnosed as a chronic blepharoconjunctivitis Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas https://www.reviewofophthalmology.com/article/eyelid-lesions-diagnosis-and- tt t Clinical Features • Pedunculated lesion: SC may become pedunculated with Clinical Presentation keratinization and possess a cutaneous horn appearance. • Most common ocular location is the eyelid margin, from the gland of Zeis. • Solitary nodule • Diffuse pseudoinflammatory pattern • Pedunculated lesion • Caruncular mass Pedunculated lesion of the axilla Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas http://www.actasdermo.org/en/extraocular-sebaceous-carcinoma-a-report/articulo/S1578219012003113/ 5 3/24/2017 Clinical Features Gross Pathology • Yellow color due to the lipid deposition. Caruncular mass: Irregular, yellow mass in the medial canthal lesion. May replace the entire eyelid and involve the orbit. • Specimens may show origin in the tarsal plate. Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas http://www.aaopt.org/optometry-and-vision-science-ovs-announces-preview-march- 2014 Gross Pathology Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas Microscopic Pathology • Cells with finely vacuolated, frothy cytoplasm • Pleomorphism and high nuclear mitotic rate are frequent features • Tumor cells often have hyperchromatic, atypical nuclei with foamy cytoplasm Involvement of Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous Gland Carcinomas sebaceous glands 6 3/24/2017 • Vacuolated Microscopic Pathology cytoplasm • A characteristic feature of SC is its ability to exhibit intraepithelial spread into conjunctival, eyelid and corneal epithelium, this occurs in 44-80% of the cases (pagetoid spread). • Mitotic figures • Pleomorphic nuclei Biomarkers in Sebaceous Gland Carcinomas Biomarkers in Sebaceous
Load more

Recommended publications
  • Sample Research Poster
    Surgical management and lymph node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients Amrita Goyal MD, 1 Theodore Marghitu,2 Nikhil Goyal BS,3 Nathan Rubin MS,4 Krishnan Patel MD,6 Kavita Goyal MD,1 Daniel O’Leary MD,5 Kimberly Bohjanen MD, 1 Ian Maher MD 1 1Department of Dermatology, University of Minnesota, Minneapolis, MN 2University of Minnesota Medical School, Minneapolis, MN 3National Institutes of Health/National Cancer Institute, Bethesda, MD 4Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis MN 5Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 6Department of Radiation Oncology, University of Minnesota, Minneapolis, MN Background Overall and Disease-Specific Survival Lymph Node Biopsy and Survival Cutaneous adnexal carcinomas comprise a group of Vital status* All Sweat Hidradenocarc Spiradenocarci Sclerosin Porocarcin Eccrine Sebaceous Lymph Nodes All adnexal tumors adnexal gland inoma noma g sweat oma adenocarci carcinoma Lymph Nodes Examined carcino duct noma Nodes not examined 6592 (91.9) rare cutaneous malignancies that are generally ma tumor Nodes examined 578 (8.1) (MAC) Positive (% of examined) 138 (23.9) considered non-aggressive. Guidelines for the Stage (Derived AJCC N=1863 N=70 N=127 N=46 N=236 N=229 N=187 N=968 Negative (% of examined) 440 (76.1) Stage Group, 6th ed treatment of many of these malignancies are sparse, (2004-2015) Total N=1221 5-year OS 5-year DSS 1,2 I 1221 40 (57.1) 56 (44.1) 14 (30.4) 150 140 (61.1) 103 (55.1) 718 (74.2) Stage I Examined N=112 including guidance on surgical management (65.5) (63.6) Nodes not examined (% of total) 1109 (90.8) 69.7 (66.1-72.4) 99.3 (99.6-100) 3,4 II 440 14 (20.0) 54 (47.5) 28 (60.9) 47 (19.9) 64 (27.9) 51 (27.3) 182 (18.8) Nodes positive (% of examined) 0 (0) -- -- including the utility of lymph node biopsy.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2013/0172829 A1 BADAW (43) Pub
    US 2013 0172829A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0172829 A1 BADAW (43) Pub. Date: Jul. 4, 2013 (54) DRY EYE TREATMENT SYSTEMS (52) U.S. Cl. CPC .................................... A61F 9/0008 (2013.01) (71) Applicant: SIGHT SCIENCES, INC., San USPC .......................................................... 604/294 Francisco, CA (US) (72) Inventor: Paul BADAWI, San Francisco, CA (US) (57) ABSTRACT (73) Assignee: SIGHT SCIENCES, INC., San Dry eye treatment apparatus and methods are described Francisco, CA (US) herein which generally comprise a patch or strip affixed to the skin of the upper and/or lower eyelids to deliver heat or other (21) Appl. No.: 13/645,985 forms of energy, pressure, drugs, moisture, etc. (alone or in combination) to the one or more meibomianglands contained (22) Filed: Oct. 5, 2012 within the underlying skin. The treatment strip or strips include one or more strips configured to adhere to an under Related U.S. Application Data lying region of skin in proximity to one or both eyes of a (63) Continuation-in-part of application No. 13/343,407, subject such that the one or more strips allow for the subject filed on Jan. 4, 2012. to blink naturally without restriction from the one or more patches. Moreover, the one or more Strips may be configured Publication Classification to emit energy to the underlying region of skin and where the one or more strips are shaped to follow a location of one or 51) Int.nt. CC. more me1bOm1amibomiam gland S COnta1nedined W1thinwithin the underlyingunderW1n A6DF 9/00 (2006.01) region of skin.
    [Show full text]
  • The Complexity and Origins of the Human Eye: a Brief Study on the Anatomy, Physiology, and Origin of the Eye
    Running Head: THE COMPLEX HUMAN EYE 1 The Complexity and Origins of the Human Eye: A Brief Study on the Anatomy, Physiology, and Origin of the Eye Evan Sebastian A Senior Thesis submitted in partial fulfillment of the requirements for graduation in the Honors Program Liberty University Spring 2010 THE COMPLEX HUMAN EYE 2 Acceptance of Senior Honors Thesis This Senior Honors Thesis is accepted in partial fulfillment of the requirements for graduation from the Honors Program of Liberty University. ______________________________ David A. Titcomb, PT, DPT Thesis Chair ______________________________ David DeWitt, Ph.D. Committee Member ______________________________ Garth McGibbon, M.S. Committee Member ______________________________ Marilyn Gadomski, Ph.D. Assistant Honors Director ______________________________ Date THE COMPLEX HUMAN EYE 3 Abstract The human eye has been the cause of much controversy in regards to its complexity and how the human eye came to be. Through following and discussing the anatomical and physiological functions of the eye, a better understanding of the argument of origins can be seen. The anatomy of the human eye and its many functions are clearly seen, through its complexity. When observing the intricacy of vision and all of the different aspects and connections, it does seem that the human eye is a miracle, no matter its origins. Major biological functions and processes occurring in the retina show the intensity of the eye’s intricacy. After viewing the eye and reviewing its anatomical and physiological domain, arguments regarding its origins are more clearly seen and understood. Evolutionary theory, in terms of Darwin’s thoughts, theorized fossilization of animals, computer simulations of eye evolution, and new research on supposed prior genes occurring in lower life forms leading to human life.
    [Show full text]
  • 第32回日本皮膚病理組織学会学術大会 診断投票結果 口演 1 Drug Eruption 13, うち Erythema Multif
    第３２回日本皮膚病理組織学会学術大会 診断投票結果 口演 1 Drug eruption 13, うち erythema multiforme 1, Interface dermatitis 1, GVHD type 1 Cutaneous reaction due to CCR4 3, うち Dysplastic epidermal hyperplasia 2, Adverse reaction 1 Erythema multiforme 3 PLEVA 1 Vacuolar type interface dermatitis 1 口演 2 Syringofibroadenoma 15, うち + amyloid 1 Syringofibroadenoma with BCC 5 Basal cell carcinoma 4, うち Pinkus type of BCC with syringofibroadenoma 2 口演 3 Darier disease 5 Hailey-Hailey disease 4 Pemphigus 3, うち Pemphigus Vegetans 1, Neonatal pemphigus 1 Grover's disease 4 Epidermal nevus 5, うち Acantholytic (dyskeratotic) epidermal nevus 4, Linear epidermal nevus 1 口演 4 Hydradenoma 13, うち Clear cell hidradenoma 12, Nodular hidradenoma 1 Sebaceous adenoma 1 Trichilemmoma 1 Metastatic tumor 8, うち ～ renal carcinoma6, ～ Clear cell carcinoma 2 口演 5 Apocrine carcinoma 3, うち ～with pagetoid spreading 2 Ectopic breast carcinoma(invasive ductal type)with pagetoid phenomenon 2 Extramammary Paget's disease 12, うち Paget carcinoma 3, ～ with Apocrine adenoma 2, ～ with Tubular adenoma 1, Invasive ～ 1, +Skin metastasis 1, With syringoma 1, with Microcystic Adnexal Carcinoma 1 Syringomatous carcinoma 2, うち ～with paget phenomenon 1 Tubular adenocartinoma 1 Tubular (apocrine) adenoma 2 Syringoma 1 口演 6 Dermatofibroma 10, うち Lipidized ～ 3, Hemosiderotic deep cellular ～ 2, Xanthomatous ～ 1, ～ Histiocytoid variant 1 Fibous histiocytoma 8, うち Atypical ～ 3, Malignant ～ 2, Aneurismal ～ 2 Undifferentiated pleomorphic sarcoma 2 Progressive nodular histiocytosis 1 Squamous
    [Show full text]
  • An Institutional Experience
    Original Research Article Skin Adnexal Tumors- An Institutional Experience 1 2* 3 4 5 6 Rekha M Haravi , Roopa K N , Priya Patil , Rujuta Datar , Meena N Jadhav , Shreekant K Kittur 1,5Associate Professor, 2Post Graduate Student, 3,4Assistant Professor, 6Professor & HOD, Department of Pathology, Belgaum Institute of Medical Sciences Dr B R Ambedkar Road, Belagavi, Karnataka – 590001, INDIA. Email: [email protected] Abstract Background: Skin adnexal tumors are a wide spectrum of benign and malignant tumors that differentiate towards one or more adnexal structures found in normal skin. The adnexal structures of skin are the hair follicles, sebaceous glands, eccrine and apocrine sweat glands. These skin adnexal tumors are often difficult to diagnose clinically. This retrospective study was undertaken to know the various histomorphological patterns of skin adnexal tumors at our institution and to determine the incidence among the genders and age groups along with the site distribution. Materials and methods: A total of 40 specimens received and diagnosed as skin adnexal tumors in the department of Pathology at Belgaum Institute of Medical Sciences, Belagavi for a period of 6 years from January 2014 to December 2019 were taken for the study. Histopathological slides prepared from tissue blocks retrieved from departmental archives were reviewed and classified according to the WHO classification 2017. Results: Out of the total 40 samples, benign tumors were 36 (90%) and malignant were 4 (10%). Largest group was the benign tumors of apocrine and eccrine differentiation (47.5%) followed by benign tumors of hair follicle differentiation (40%). Malignant tumors of sebaceous differentiation were 5%, malignant tumors of eccrine and apocrine differentiation were 2.5% and malignant hair follicle differentiation tumors were 2.5% of the total.
    [Show full text]
  • Study Guide Medical Terminology by Thea Liza Batan About the Author
    Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails ­proficiency­in­communicating­with­healthcare­professionals­such­as­physicians,­nurses,­ or dentists.
    [Show full text]
  • Eyelids (2 Lec.)
    Eyelids (2 lec.) Dr Abdulmelik shallal Anatomy: Eyelids are thin movable curtains composed of skin on their anterior surface and mucus membrane (conjunctiva) on the posterior surface, they contain: 1- Smooth muscles (Müller's muscles). 2- Striated muscles (Orbicularis oculi and Levator palpebrae superioris "LPS"). 3- Dense fibrous plates (Tarsal plates). 4- Glands. 5- Nerves and blood vessels. 1 The contents of the lid are distributed as follows: the anterior surface is made of skin which has a round edge with the lid margin, the subcutaneous tissue, muscular layer, the submuscular (areolar tissue) layer, the orbital septum which end as a tarsal plate (that forms the architecture of lid) and finally the conjunctiva (palpebral) which is situated most posterior. The free margin of the eyelids contains: 1- The lashes (Cilia). 2- Grey line. 3- Orifices of Meibomian glands. 4- Mucocutaneous junction 5- Superior and inferior puncti of Naso-Lacrimal System (NLS). Muscles of the eyelids: 1- Orbicularis oculi muscle: It is a thin oval sheet of concentric striated muscle surrounding the palpebral fissure. It can be divided into: a- Peripheral (orbital) part: This is involved in forceful closure of lids. b- Central (palpebral) part: This is involved in involuntary blinking, voluntary nonforceful closure and participates in forceful closure with the orbital part. c- Muscle of Rioland's: this part is represented by the gray line of lid margin. d- lacrimalis muscle: that attached to the fundus of lacrimal sac. This part is involved in pumping action of lacrimal drainage system. Nerve supply: Sensory: Ophthalmic branch of trigeminal nerve Motor: Facial nerve.
    [Show full text]
  • Eyelid Conjunctival Tumors
    EYELID &CONJUNCTIVAL TUMORS PHOTOGRAPHIC ATLAS Dr. Olivier Galatoire Dr. Christine Levy-Gabriel Dr. Mathieu Zmuda EYELID & CONJUNCTIVAL TUMORS 4 EYELID & CONJUNCTIVAL TUMORS Dear readers, All rights of translation, adaptation, or reproduction by any means are reserved in all countries. The reproduction or representation, in whole or in part and by any means, of any of the pages published in the present book without the prior written consent of the publisher, is prohibited and illegal and would constitute an infringement. Only reproductions strictly reserved for the private use of the copier and not intended for collective use, and short analyses and quotations justified by the illustrative or scientific nature of the work in which they are incorporated, are authorized (Law of March 11, 1957 art. 40 and 41 and Criminal Code art. 425). EYELID & CONJUNCTIVAL TUMORS EYELID & CONJUNCTIVAL TUMORS 5 6 EYELID & CONJUNCTIVAL TUMORS Foreword Dr. Serge Morax I am honored to introduce this Photographic Atlas of palpebral and conjunctival tumors,which is the culmination of the close collaboration between Drs. Olivier Galatoire and Mathieu Zmuda of the A. de Rothschild Ophthalmological Foundation and Dr. Christine Levy-Gabriel of the Curie Institute. The subject is now of unquestionable importance and evidently of great interest to Ophthalmologists, whether they are orbital- palpebral specialists or not. Indeed, errors or delays in the diagnosis of tumor pathologies are relatively common and the consequences can be serious in the case of malignant tumors, especially carcinomas. Swift diagnosis and anatomopathological confirmation will lead to a treatment, discussed in multidisciplinary team meetings, ranging from surgery to radiotherapy.
    [Show full text]
  • A Rare Clinical Presentation of Desmoplastic Trichilemmoma
    Revista5Vol89ingles_Layout 1 8/8/14 10:17 AM Página 796 796 CASE REPORT s A rare clinical presentation of Desmoplastic Trichilemmoma mimicking Invasive Carcinoma* Daniela Tiemi Sano1 Jeane Jeong Hoon Yang1 Antonio José Tebcherani1 Luiz Arthur de Paula Machado Bazzo1 DOI: http://dx.doi.org/10.1590/abd1806-4841.20143095 Abstract: Trichilemmoma is a benign neoplasm from the outer sheath of the pilosebaceous follicle. Desmoplastic trichilemmoma, a rare variant, is histologically characterized by a central area of desmoplasia that can clinically mimic an invasive carcinoma, requiring histopathological examination to define the diagnosis. Keywords: Hair diseases; Hair follicle; Skin neoplasms INTRODUCTION The trichilemmoma is a benign solid tumor ori- ma, without the presence of malignant processes, and ginating from external sheath cells of pilosebaceous associated with nevus sebaceous of Jadassohn in the follicles, and the desmoplastic trichilemmoma is a rare periphery of the lesion (Figures 3, 4, 5 and 6). Patient benign histological variant.1,2,3 Clinically, it may look is still under outpatient follow-up, with good clinical like other cutaneous lesions.2 Among the differential evolution and no relapse of lesion. diagnoses, we can cite basal-cell carcinoma, squamous cell carcinoma and viral lesions; the histopathological DISCUSSION examination is necessary for diagnostic confirmation. The trichilemmoma is a benign tumor origina- We report here a case of desmoplastic trichilemmoma ting from external root sheath cells of pilosebaceous in a
    [Show full text]
  • Pdf 344.65 K
    Differential Diagnosis of Basal Cell Carcinoma and Benign Tumors of Hair Follicles Using CD34 RESEARCH COMMUNICATION Differential Diagnosis of Basal Cell Carcinoma and Benign Tumors of Cutaneous Appendages Originating from Hair Follicles by Using CD34 Demet Sengul1, Ilker Sengul2*, Muzeyyen Hesna Astarci3, Huseyin Ustun3, Gamze Mocan4 Abstract Background and Aims: Differential diagnosis of the group of benign trichoblastomas, trichofolliculomas, trichoadenomas and trichoepitheliomas, and basal cell carcinomas (BCCs) is troublesome for the clinician as well as the pathologist, especially when only small biopsy specimens are available. Here we investigated whether CD34 expression might be of assistance. Methods: Thirty benign tumors of cutaneous appendages originating from hair follicles (BTCOHF) and 30 BCCs were retrieved from our archives and immunohistochemically stained. CD 34 expression was graded from [0] to [2+] and compared among the groups and subgroups. Results: There was no significant difference between the degree of expression between [0] and [1+] and [0] and [2+] for each group. However, [1+] and [2+] immunopositivity of BTCOHFs was significantly stronger than in BCCs (p= 0.014). Conclusions: CD34 may contribute to differential diagnosis of skin lesions. Keywords: Basal cell cancer - hair follicle lesions - CD 34 immunohistochemistry Asian Pacific J Cancer Prev, 11, 1615-1619 Introduction in 1958. TAs occur as a nodular lesion usually on the face and buttocks (Rahbari et al., 1977, Swaroop et al., 2008) Ackerman et al classified benign tumors of cutaneous and have a variant of verrucous TA mimicing seboreic appendages originating from hair follicle (BTCOHF)’s keratosis. using eight textbooks of dermatopathology in 2001 as Trichoepithelioma (TE) is a benign skin tumor with germ tumors of hair follicle and hamartomas, infindubular follicular differentiation determined in the classification and isthmic tumors, tumors of external layer, tumors of WHO as the synonym of TB (Cotton, 1991).
    [Show full text]
  • Surgical Excision of Eyelid Lesions Reference Number: CP.VP.75 Coding Implications Last Review Date: 12/2020 Revision Log
    Clinical Policy: Surgical Excision of Eyelid Lesions Reference Number: CP.VP.75 Coding Implications Last Review Date: 12/2020 Revision Log See Important Reminder at the end of this policy for important regulatory and legal information. Description: The majority of eyelid lesions are benign, ranging from innocuous cysts and chalazion/hordeolum to nevi and papillomas. Key features that should prompt further investigation include gradual enlargement, central ulceration or induration, irregular borders, eyelid margin destruction or loss of lashes, and telangiectasia. This policy describes the medical necessity requirements for surgical excision of eyelid lesions. Policy/Criteria I. It is the policy of health plans affiliated with Centene Corporation® (Centene) that surgical excision and repair of eyelid or conjunctiva due to lesion or cyst or eyelid foreign body removal is medically necessary for any of the following indications: A. Lesion with one or more of the following characteristics: 1. Bleeding; 2. Persistent or intense itching; 3. Pain; 4. Inflammation; 5. Restricts vision or eyelid function; 6. Misdirects eyelashes or eyelid; 7. Displaces lacrimal puncta or interferes with tear flow; 8. Touches globe; 9. Unknown etiology with potential for malignancy; B. Lesions classified as one of the following: 1. Malignant; 2. Benign; 3. Cutaneous papilloma; 4. Cysts; 5. Embedded foreign bodies; C. Periocular warts associated with chronic conjunctivitis. Background The majority of eyelid lesions are benign, ranging from innocuous cysts and chalazion/hordeolum to nevi and papillomas. Key features that should prompt further investigation include gradual enlargement, central ulceration or induration, irregular borders, eyelid margin destruction or loss of lashes, and telangiectasia. Benign tumors, even though benign, often require removal and therefore must be examined carefully and the differential diagnosis of a malignant eyelid tumor considered and the method of removal planned.
    [Show full text]
  • Histopathology of Dermal Adnexal Tumours - a Four Years Study
    International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064 Index Copernicus Value (2013): 6.14 | Impact Factor (2015): 6.391 Histopathology of Dermal Adnexal Tumours - A Four Years Study Mukund Dhokiya1, Dr. Hemlata Talwelkar2, Dr. Sanjay Talwelkar3 13rd year Postgraduate Student, PDU Medical College & Hospital, Rajkot, India 2DA, MBBS, PDU Medical College & Hospital, Rajkot, India 3MD Pathology, Associate Professor, PDU Medical College & Hospital, Rajkot, India Abstract: Background: Dermal adnexal tumours (DAT) are a large and diverse group of benign and malignant tumours which exhibit morphological differentiation towards one of the different types of adnexal tumours present in normal skin: pilosebaeceous unit, eccrine and apocrine. Methods: 50 cases of skin adnexal tumours diagnosed in histopathological study over a period of 4 years (May 2012 to September 2016) in the Department of Pathology, PDU Medical College, Rajkot. Histopathological study is done in Formalin fixed, Paraffin embedded tissue sections stained with Haematoxylin and Eosin. Results: Skin adnexal tumours found most common in the age group of 21 to 60 years (74%, 37/50). Male to female ratio was 1:1.2. 98% cases found benign with only a single case (2%) malignant. The sweat gland tumors formed the largest group involving 52% of cases followed by hair follicle tumors (40%),sebaceous gland tumours (6%) and mixed (2%). Nodular hidradenoma (22%) and trichilemmal cyst (22%) found the most common benign tumours. Chondroid syringoma with malignant changes is the only malignant adnexal tumour reported in our study. Conclusion: Dermal adnexal tumours are relatively rare. Benign adnexal tumors are far more common than their malignant counterparts.
    [Show full text]