DOCSLIB.ORG

Toxicon 60 (2012) 95–248

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Toxicon 60 (2012) 95–248 Toxicon 60 (2012) 95–248 Contents lists available at SciVerse ScienceDirect Toxicon journal homepage: www.elsevier.com/locate/toxicon 17th World Congress of the International Society on Toxinology & Venom Week 2012 Honolulu, Hawaii, USA, July 8–13, 2012 Abstract Editors: Steven A. Seifert, MD and Carl-Wilhelm Vogel, MD, PhD 0041-0101/$ – see front matter 10.1016/j.toxicon.2012.04.354 96 Abstracts Toxins 2012 / Toxicon 60 (2012) 95–248 Abstracts Toxins 2012 Contents A. Biotoxins as Bioweapons. ...............................................................................97 B. Drug Discovery & Development..........................................................................100 C. Evolution of Toxins & Venom Glands . .....................................................................119 D. Hemostasis. ......................................................................................128 E. History of Toxinology . ..............................................................................137 F. Insects . ...........................................................................................141 G. Marine . ...........................................................................................144 H. Microbial Toxins. ..................................................................................157 I. Miscellaneous . ......................................................................................164 J. Pharmacology . ......................................................................................165 K. Physiology . ......................................................................................175 L. Plants . ...........................................................................................177 M. Scorpions . ......................................................................................180 N. Snakes . ...........................................................................................191 O. Spiders. ...........................................................................................228 P. Systems & Training . ..................................................................................236 Q. Venomous Animal Biology . ..........................................................................239 R. Venomous Animal Collections. ..........................................................................242 S. Veterinary Toxinology . ..............................................................................246 This issue of Toxicon contains the abstracts presented at the The joint meeting of the 17th World Congress of the IST 17th World Congress of the International Society on Tox- and Venom Week 2012 is intended to be a forum of inology (IST), held jointly with Venom Week 2012, 4th scientific exchange among the members of the toxinology International Scientific Symposium on All Things Venomous, communities from around the globe. It is hoped that the in Honolulu, Hawaii, USA, July 8–13, 2012. unique location of Hawaii enhances the meeting experi- The World Congress of IST is held every three years, ence. Hawaii is indeed a very special place. The most most recently in Recife, Brazil in March 2009. The IST northern part of Polynesia, it is the most isolated land mass World Congress is the primary international meeting in the world with a sizable population. It is characterized by bringing together scientists and physicians from around an unparalleled cultural diversity, where the East meets the the world to discuss the most recent advances in the West, and where the host culture is Hawaiian. Although structure and function of natural toxins occurring in part of the United States, it is a fitting place to serve as host venomous animals, plants, or microorganisms, in medical, for the Asia-Pacific Region of the IST for its World Congress. public health, and policy approaches to prevent or treat Oahu, the island on which Honolulu is located, is envenomations, and in the development of new toxin- a Hawaiian name and means “Gathering Place”. Appropri- derived drugs. The Venom Week Symposiums, previously ately, it will be the gathering place for the world toxinology held in 2005, 2007 and 2009, are held in the USA with an community in 2012. international faculty and focus, and present the most Many thanks go to the Executive Committee of IST, Pres- recent advances in terrestrial and marine envenomations ident Dr. Ponnampalam Gopalakrishnakone (Singapore), of medical and veterinary importance, in venom and Secretary/Treasurer Dr. Julian White (Australia), and antivenom basic science, in the handling and breeding of President-Elect Dr. Alan Harvey (United Kingdom), to the venomous animals in zoos and aquaria, in venomous members of both the international Scientific Organizing animal science, and in regulatory issues. As both meetings Committee, the Local Organizing Committee, and to the were scheduled to be held in the summer of 2012 in the many sponsors for helping to make the 17th IST World USA, the two organizations decided to hold a joint Congress / Venom Week 2012 Meeting a reality and success. meeting in Honolulu. Meeting Co-Chairs The program of the meeting is characterized by two Steven A. Seifert, MD (USA) parallel tracks, basic sciences and clinical sciences, thereby Carl-Wilhelm Vogel, MD, PhD (USA) providing venues for presenting advances in these two Members of the Scientific Organizing Committee broad areas of toxinology research as well as translational Alejandro Alagon (MEXICO) aspects that bridge these two components. Some sessions Greta Binford (USA) on important topics are organized by eminent scientists Leslie V. Boyer (USA) in their field, whereas other sessions were developed Sean P. Bush (USA) from the more than 300 abstracts submitted to the Juan J. Calvete (SPAIN) meeting. Jean-Philippe Chippaux (BENIN) Abstracts Toxins 2012 / Toxicon 60 (2012) 95–248 97 Yara Cury (BRAZIL) Drug Information Center, MSC09 5080, 1 University of New Richard C. Dart (USA) Mexico, Albuquerque, NM 87131-0001 USA P Gopalakrishnakone (SINGAPORE) Email: [email protected] Eugene Grishin (RUSSIA) Michael Gurevitz (ISRAEL) José María Gutiérrez (COSTA RICA) A. Biotoxins as Bioweapons Abdulrazaq G. Habib (NIGERIA) Alan Harvey (UK) Dan E. Keyler (USA) 1. Detection Technologies for Biological Toxins Glenn King (AUSTRALIA) Jessi Krebs (USA) P. Gopalakrishnakone Stephen P. Mackessy (USA) Venom &Toxin Research Programme, YLL School of Medicine, National Ashis k. Mukherjee (INDIA) University of Singapore, Singapore E-mail address: [email protected]. Kini R Manjunatha (SINGAPORE) Cesare Montecucco (ITALY) Review: The ad hoc group of the states parties to “the Dietrich Mebs (GERMANY) convention on the prohibition of the development, produc- Tarek R. Rahmy (EGYPT) tion and stock piling of biological and toxin weapons and on Karen Seibold (USA) their destruction” has listed the following toxins, bacter- Steven A. Seifert (USA) iotoxins (Botulinum toxin, clostridium perfringens toxins, Denis Servent (FRANCE) staphylococcal enterotoxins, shigatoxins), Phycotoxins (Ana- Reto Stöcklin (SWITZERLAND) toxins, ciguatoxins, saxitoxins), Mycotoxins (trichothecenes), Denise V. Tambourgi (BRAZIL) Phytotoxins (Abrins,Ricins) Zootoxins (Bungarotoxins). In Toru Tamiya (JAPAN) addition, few other toxins which are not in this list such as Jan Tytgat (BELGIUM) brevetoxins, conotoxins and other neurotoxins also will be Carl-Wilhelm Vogel (USA) reviewed in addition to the work done by venom and toxin Julian White (AUSTRALIA) research programme at National University of Singapore. An overview of the different technologies available for the Members of the Local Organizing Committee detection of biological toxins, originating from animals, Brian E. Hew (Black Ivory Biotech, Aiea, Hawaii) plants and microbial organism will be described. The meth- Ben Okimoto (Honolulu Zoo, Hawaii) odologies/technologies vary from fieldable ones to highly John M. Pezzuto (University of Hawaii at Hilo) sensitive one to user friendly ones. Depending on the Andrew Rossiter (Waikiki Aquarium, Hawaii) purpose of detection of toxin vary in different circumstance, Steven A. Seifert (University of New Mexico) quantitatively or qualitatively starting from Ouchterlony Carl-Wilhelm Vogel (University of Hawaii at Manoa) diffusion test to classical ELISA kit which has been used for Julian White (Women’s and Children’s Hospital, Adelaide) many years for the detection of biological toxins as well as Catherine Wood (University of New Mexico) HPLC, LCMS. In the recent past our research group has developed immunosensitive field – Effect Transistors (ISFET) Sponsors (1), ultrasensitive protein array based on electrochemical Rare Disease Therapeutics, Inc., Franklin, Tennessee, USA enzyme immunoassay (EETA) (2), silicon chip base optical BTG International, Ltd., London, UK immunoassay (OIA) (3) for the detection of toxins from Instituto Bioclon, Mexico City, Mexico animal venoms as well as toxin from microbial organisms Silanes Laboratories, S.A., Mexico such as Botulinum toxins, SEB toxin, T-2 toxins as well as Toxicon American International Rattlesnake Museum, plant toxins such as ricin or abrin. Albuquerque, NM, USA Chiricahua Desert Museum, Rodeo, NM / Elsevier B.V., Amsterdam, The Netherlands References International Society on Toxinology Zakaria.E.S, Gopalakrishnakone, P. & Pavel, N. Immunolog- College of Pharmacy, University of Hawaii at Hilo, ically sensitive field effect transistors. Encyclopedia of Honolulu, HI University of New
Load more

Recommended publications
  • Phylogenetic Diversity, Habitat Loss and Conservation in South
    Diversity and Distributions, (Diversity Distrib.) (2014) 20, 1108–1119 BIODIVERSITY Phylogenetic diversity, habitat loss and RESEARCH conservation in South American pitvipers (Crotalinae: Bothrops and Bothrocophias) Jessica Fenker1, Leonardo G. Tedeschi1, Robert Alexander Pyron2 and Cristiano de C. Nogueira1*,† 1Departamento de Zoologia, Universidade de ABSTRACT Brasılia, 70910-9004 Brasılia, Distrito Aim To analyze impacts of habitat loss on evolutionary diversity and to test Federal, Brazil, 2Department of Biological widely used biodiversity metrics as surrogates for phylogenetic diversity, we Sciences, The George Washington University, 2023 G. St. NW, Washington, DC 20052, study spatial and taxonomic patterns of phylogenetic diversity in a wide-rang- USA ing endemic Neotropical snake lineage. Location South America and the Antilles. Methods We updated distribution maps for 41 taxa, using species distribution A Journal of Conservation Biogeography models and a revised presence-records database. We estimated evolutionary dis- tinctiveness (ED) for each taxon using recent molecular and morphological phylogenies and weighted these values with two measures of extinction risk: percentages of habitat loss and IUCN threat status. We mapped phylogenetic diversity and richness levels and compared phylogenetic distances in pitviper subsets selected via endemism, richness, threat, habitat loss, biome type and the presence in biodiversity hotspots to values obtained in randomized assemblages. Results Evolutionary distinctiveness differed according to the phylogeny used, and conservation assessment ranks varied according to the chosen proxy of extinction risk. Two of the three main areas of high phylogenetic diversity were coincident with areas of high species richness. A third area was identified only by one phylogeny and was not a richness hotspot. Faunal assemblages identified by level of endemism, habitat loss, biome type or the presence in biodiversity hotspots captured phylogenetic diversity levels no better than random assem- blages.
    [Show full text]
  • Rachel Carson for SILENT SPRING
    Silent Spring THE EXPLOSIVE BESTSELLER THE WHOLE WORLD IS TALKING ABOUT RACHEL CARSON Author of THE SEA AROUND US SILENT SPRING, winner of 8 awards*, is the history making bestseller that stunned the world with its terrifying revelation about our contaminated planet. No science- fiction nightmare can equal the power of this authentic and chilling portrait of the un-seen destroyers which have already begun to change the shape of life as we know it. “Silent Spring is a devastating attack on human carelessness, greed and irresponsibility. It should be read by every American who does not want it to be the epitaph of a world not very far beyond us in time.” --- Saturday Review *Awards received by Rachel Carson for SI LENT SPRING: • The Schweitzer Medal (Animal Welfare Institute) • The Constance Lindsay Skinner Achievement Award for merit in the realm of books (Women’s National Book Association) • Award for Distinguished Service (New England Outdoor Writers Association) • Conservation Award for 1962 (Rod and Gun Editors of Metropolitan Manhattan) • Conservationist of the Year (National Wildlife Federation) • 1963 Achievement Award (Albert Einstein College of Medicine --- Women’s Division) • Annual Founders Award (Isaak Walton League) • Citation (International and U.S. Councils of Women) Silent Spring ( By Rachel Carson ) • “I recommend SILENT SPRING above all other books.” --- N. J. Berrill author of MAN’S EMERGING MIND • "Certain to be history-making in its influence upon thought and public policy all over the world." --Book-of-the-Month Club News • "Miss Carson is a scientist and is not given to tossing serious charges around carelessly.
    [Show full text]
  • Medical Problems and Treatment Considerations for the Red Imported Fire Ant
    MEDICAL PROBLEMS AND TREATMENT CONSIDERATIONS FOR THE RED IMPORTED FIRE ANT Bastiaan M. Drees, Professor and Extension Entomologist DISCLAIMER: This fact sheet provides a review of information gathered regarding medical aspects of the red imported fire ant. As such, this fact sheet is not intended to provide treatment recommendations for fire ant stings or reactions that may develop as a result of a stinging incident. Readers are encouraged to seek health-related advice and recommendations from their medical doctors, allergists or other appropriate specialists. Imported fire ants, which include the red imported fire ant - Solenopsis invicta Buren (Hymenoptera: Formicidae), the black imported fire ant - Solenopsis richteri Forel and the hybrid between S. invicta and S. richteri, cause medical problems when sterile female worker ants from a colony sting and inject a venom that cause localized sterile blisters, whole body allergic reactions such as anaphylactic shock and occasionally death. In Texas, S. invicta is the only imported fire ant, although several species of native fire ants occur in the state such as the tropical fire ant, S. geminata (Fabricius), and the desert fire ant, S. xyloni McCook, which are also capable of stinging (see FAPFS010 and 013 for identification keys). Over 40 million people live in areas infested by the red imported fire ant in the southeastern United States. An estimated 14 million people are stung annually. According to The Scripps Howard Texas Poll (March 2000), 79 percent of Texans have been stung by fire ants in the year of the survey, while 20% of Texans report not ever having been stung.
    [Show full text]
  • Interactions of Insecticidal Spider Peptide Neurotoxins with Insect Voltage- and Neurotransmitter-Gated Ion Channels
    Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels (Molecular representation of - HXTX-Hv1c including key binding residues, adapted from Gunning et al, 2008) PhD Thesis Monique J. Windley UTS 2012 CERTIFICATE OF AUTHORSHIP/ORIGINALITY I certify that the work in this thesis has not previously been submitted for a degree nor has it been submitted as part of requirements for a degree except as fully acknowledged within the text. I also certify that the thesis has been written by me. Any help that I have received in my research work and the preparation of the thesis itself has been acknowledged. In addition, I certify that all information sources and literature used are indicated in the thesis. Monique J. Windley 2012 ii ACKNOWLEDGEMENTS There are many people who I would like to thank for contributions made towards the completion of this thesis. Firstly, I would like to thank my supervisor Prof. Graham Nicholson for his guidance and persistence throughout this project. I would like to acknowledge his invaluable advice, encouragement and his neverending determination to find a solution to any problem. He has been a valuable mentor and has contributed immensely to the success of this project. Next I would like to thank everyone at UTS who assisted in the advancement of this research. Firstly, I would like to acknowledge Phil Laurance for his assistance in the repair and modification of laboratory equipment. To all the laboratory and technical staff, particulary Harry Simpson and Stan Yiu for the restoration and sourcing of equipment - thankyou. I would like to thank Dr Mike Johnson for his continual assistance, advice and cheerful disposition.
    [Show full text]
  • Peking University-Juntendo University Joint Symposium on Cancer Research and Treatment ADAM28 (A Disintegrin and Metalloproteinase 28) in Cancer Cell Proliferation and Progression
    Whatʼs New from Juntendo University, Tokyo Juntendo Medical Journal 2017. 63(5), 322-325 Peking University - Juntendo University Joint Symposium on Cancer Research and Treatment ADAM28 (a Disintegrin and Metalloproteinase 28) in Cancer Cell Proliferation and Progression YASUNORI OKADA＊ ＊Department of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo University Graduate School of Medicine, Tokyo, Japan A disintegrinandmetalloproteinase 28 (ADAM28) is overexpressedpredominantlyby carcinoma cells in more than 70% of the non-small cell lung carcinomas, showing positive correlations with carcinoma cell proliferation and metastasis. ADAM28 cleaves insulin-like growth factor binding protein-3 (IGFBP-3) in the IGF-I/IGFBP-3 complex, leading to stimulation of cell proliferation by intact IGF-I released from the complex. ADAM28 also degrades von Willebrand factor (VWF), which induces apoptosis in human carcinoma cell lines with negligible ADAM28 expression, andthe VWF digestionby ADAM28-expressing carcinoma cells facilitates them to escape from VWF-induced apoptosis, resulting in promotion of metastasis. We have developed human antibodies against ADAM28 andshown that one of them significantly inhibits tumor growth andmetastasis using lung adenocarcinoma cells. Our data suggest that ADAM28 may be a new molecular target for therapy of the patients with ADAM28-expressing non-small cell lung carcinoma. Key words: a disintegrin and metalloproteinase 28 (ADAM28), cell proliferation, invasion, metastasis, human antibody inhibitor Introduction human cancers 2). However, development of the synthetic inhibitors of MMPs andtheir application Cancer cell proliferation andprogression are for treatment of the cancer patients failed 3). modulated by proteolytic cleavage of tissue micro- On the other hand, members of the ADAM (a environmental factors such as extracellular matrix disintegrin and metalloproteinase) gene family, (ECM), growth factors andcytokines, receptors another family belonging to the metzincin gene andcell adhesionmolecules.
    [Show full text]
  • Zootaxa, Molecular Phylogeny, Classification, and Biogeography Of
    Zootaxa 2067: 1–28 (2009) ISSN 1175-5326 (print edition) www.mapress.com/zootaxa/ Article ZOOTAXA Copyright © 2009 · Magnolia Press ISSN 1175-5334 (online edition) Molecular phylogeny, classification, and biogeography of West Indian racer snakes of the Tribe Alsophiini (Squamata, Dipsadidae, Xenodontinae) S. BLAIR HEDGES1, ARNAUD COULOUX2, & NICOLAS VIDAL3,4 1Department of Biology, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802-5301 USA. E-mail: [email protected] 2Genoscope. Centre National de Séquençage, 2 rue Gaston Crémieux, CP5706, 91057 Evry Cedex, France www.genoscope.fr 3UMR 7138, Département Systématique et Evolution, Muséum National d’Histoire Naturelle, CP 26, 57 rue Cuvier, 75005 Paris, France 4Corresponding author. E-mail : [email protected] Abstract Most West Indian snakes of the family Dipsadidae belong to the Subfamily Xenodontinae and Tribe Alsophiini. As recognized here, alsophiine snakes are exclusively West Indian and comprise 43 species distributed throughout the region. These snakes are slender and typically fast-moving (active foraging), diurnal species often called racers. For the last four decades, their classification into six genera was based on a study utilizing hemipenial and external morphology and which concluded that their biogeographic history involved multiple colonizations from the mainland. Although subsequent studies have mostly disagreed with that phylogeny and taxonomy, no major changes in the classification have been proposed until now. Here we present a DNA sequence analysis of five mitochondrial genes and one nuclear gene in 35 species and subspecies of alsophiines. Our results are more consistent with geography than previous classifications based on morphology, and support a reclassification of the species of alsophiines into seven named and three new genera: Alsophis Fitzinger (Lesser Antilles), Arrhyton Günther (Cuba), Borikenophis Hedges & Vidal gen.
    [Show full text]
  • ANA CAROLINA MARTINS WILLE.Pdf
    UNIVERSIDADE FEDERAL DO PARANÁ ANA CAROLINA MARTINS WILLE AVALIAÇÃO DA ATIVIDADE DE FOSFOLIPASE-D RECOMBINANTE DO VENENO DA ARANHA MARROM (Loxosceles intermedia) SOBRE A PROLIFERAÇÃO, INFLUXO DE CÁLCIO E METABOLISMO DE FOSFOLIPÍDIOS EM CÉLULAS TUMORAIS. CURITIBA 2014 i Wille, Ana Carolina Martins Avaliação da atividade de fosfolipase-D recombinante do veneno da aranha marrom (Loxosceles intermedia) sobre a proliferação, influxo de cálcio e metabolismo de fosfolipídios em células tumorais Curitiba, 2014. 217p. Tese (Doutorado) – Universidade Federal do Paraná – UFPR 1.veneno de aranha marrom. 2. fosfolipase-D. 3.proliferação celular. 4.metabolismo de lipídios. 5.influxo de cálcio. ANA CAROLINA MARTINS WILLE AVALIAÇÃO DA ATIVIDADE DE FOSFOLIPASE-D RECOMBINANTE DO VENENO DA ARANHA MARROM (Loxosceles intermedia) SOBRE A PROLIFERAÇÃO, INFLUXO DE CÁLCIO E METABOLISMO DE FOSFOLIPÍDIOS EM CÉLULAS TUMORAIS. Tese apresentada como requisito à obtenção do grau de Doutor em Biologia Celular e Molecular, Curso de Pós- Graduação em Biologia Celular e Molecular, Setor de Ciências Biológicas, Universidade Federal do Paraná. Orientador(a): Dra. Andrea Senff Ribeiro Co-orientador: Dr. Silvio Sanches Veiga CURITIBA 2014 ii O desenvolvimento deste trabalho foi possível devido ao apoio financeiro do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), a Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação Araucária e SETI-PR. iii Dedico este trabalho àquela que antes da sua existência foi o grande sonho que motivou minha vida. Sonho que foi a base para que eu escolhesse uma profissão e um trabalho. À você, minha amada filha GIOVANNA, hoje minha realidade, dedico todo meu trabalho. iv Dedico também este trabalho ao meu amado marido, amigo, professor e co- orientador Dr.
    [Show full text]
  • Serine Proteases with Altered Sensitivity to Activity-Modulating
    (19) & (11) EP 2 045 321 A2 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 08.04.2009 Bulletin 2009/15 C12N 9/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/37 (2006.01) (21) Application number: 09150549.5 (22) Date of filing: 26.05.2006 (84) Designated Contracting States: • Haupts, Ulrich AT BE BG CH CY CZ DE DK EE ES FI FR GB GR 51519 Odenthal (DE) HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI • Coco, Wayne SK TR 50737 Köln (DE) •Tebbe, Jan (30) Priority: 27.05.2005 EP 05104543 50733 Köln (DE) • Votsmeier, Christian (62) Document number(s) of the earlier application(s) in 50259 Pulheim (DE) accordance with Art. 76 EPC: • Scheidig, Andreas 06763303.2 / 1 883 696 50823 Köln (DE) (71) Applicant: Direvo Biotech AG (74) Representative: von Kreisler Selting Werner 50829 Köln (DE) Patentanwälte P.O. Box 10 22 41 (72) Inventors: 50462 Köln (DE) • Koltermann, André 82057 Icking (DE) Remarks: • Kettling, Ulrich This application was filed on 14-01-2009 as a 81477 München (DE) divisional application to the application mentioned under INID code 62. (54) Serine proteases with altered sensitivity to activity-modulating substances (57) The present invention provides variants of ser- screening of the library in the presence of one or several ine proteases of the S1 class with altered sensitivity to activity-modulating substances, selection of variants with one or more activity-modulating substances. A method altered sensitivity to one or several activity-modulating for the generation of such proteases is disclosed, com- substances and isolation of those polynucleotide se- prising the provision of a protease library encoding poly- quences that encode for the selected variants.
    [Show full text]
  • Paula Henriques Cruz Ciscotto
    PAULA HENRIQUES CRUZ CISCOTTO Purificação e caracterização biológica (estrutural, antibacteriana, antiparasitária, hemolítica e antigênica) de componentes do veneno da serpente Bothrops jararaca. BELO HORIZONTE MINAS GERAIS-BRASIL 2005 PAULA HENRIQUES CRUZ CISCOTTO Purificação e caracterização biológica (estrutural, antibacteriana, antiparasitária, hemolítica e antigênica) de componentes do veneno da serpente Bothrops jararaca. Dissertação submetida ao Curso de Pós- graduação em Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais como requisito parcial para obtenção do título de mestre em Bioquímica e Imunologia. Orientador: Prof. Dr. Carlos Chávez Olórtegui BELO HORIZONTE MINAS GERAIS-BRASIL 2005 Este trabalho foi desenvolvido no Laboratório de Imunoquímica de Toxinas, do Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais. Contando com a colaboração do Laboratório de Microbiologia Oral e Anaeróbios, do Departamento de Microbiologia, do Laboratório de Enzimologia e Físico- Química de Proteínas, do Núcleo de Estrutura e Função de Biomoléculas, ambos do Departamento de Bioquímica e Imunologia, todos do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais. ii Agradecimentos Aos meus pais por sempre estarem ao meu lado, incentivando meu crescimento pessoal e profissional, e apoiando minhas decisões. Ao Luiz pelo carinho constante e incentivo permanente, por sua tolerância em momentos delicados. Graças à suas palavras de perseverança e otimismo consegui chegar ao final desta caminhada. Ao Prof. Carlos Chávez Olórtegui por me incentivar a começar esta trajetória científica pelo caminho da especialização profissional e por depositar em mim sua confiança para realização deste trabalho. Ao Jamil por seus ensinamentos, incentivo e por estar sempre disponível a me ajudar.
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,062,119 B2 Varga Et Al
    USOO90621-19B2 (12) United States Patent (10) Patent No.: US 9,062,119 B2 Varga et al. (45) Date of Patent: Jun. 23, 2015 (54) MODIFIED PEPTIDE TOXINS OTHER PUBLICATIONS (71) Applicants:Zoltan Varga, Debrecen (HU); Gyorgy Bagdanyi, M. et al. Anuroctoxin, a new scorpion toxin of the alpha Panyi, Debrecen (HU); Gabor Toth, KTX 6 subfamily, is highly selective for Kv1.3 over IKCal ion Szeged (HU); Kinga Rakosi, Szeged channels of human T lymphocytes. Mol Pharmacol (2005), vol. 67. (HU) pp. 1034-1044. Batista, CV. et al. Two novel toxins from the Amazonian scorpion (72) Inventors: Zoltan Varga, Debrecen (HU); Gyorgy Tityus cambridgei that block Kv1.3 and Shaker BK(+)-channels with Panyi, Debrecen (HU); Gabor Toth, distinctly different affinities. Biochim Biophys Acta (2002), vol. Szeged (HU); Kinga Rakosi, Szeged 1601, pp. 123-131. Beeton, C. et al. Selective blockade of T lymphocyte K+ channels (HU) ameliorates experimental autoimmune encephalomyelitis, a model (73) Assignees: University of Debrecen, Debrecen for multiple sclerosis. Proc Natl Acad Sci USA (2001), vol. 98, pp. (HU); University of Szeged, Szeged 13942-13947. Beeton, C. et al. Kv1.3 channels are a therapeutic target for T cell (HU) mediated autoimmune diseases. Proc Natl AcadSci USA (2006), vol. 103, pp. 17414-17419. (*) Notice: Subject to any disclaimer, the term of this Corzo, G. et al. A selective blocker of Kv1.2 and Kv1.3 potassium patent is extended or adjusted under 35 channels from the venom of the Scorpion Centruroides suffusus suf U.S.C. 154(b) by 0 days. fusus. Biochem Pharmacol (2008), vol.
    [Show full text]
  • Toxins-67579-Rd 1 Proofed-Supplementary
    Supplementary Information Table S1. Reviewed entries of transcriptome data based on salivary and venom gland samples available for venomous arthropod species. Public database of NCBI (SRA archive, TSA archive, dbEST and GenBank) were screened for venom gland derived EST or NGS data transcripts. Operated search-terms were “salivary gland”, “venom gland”, “poison gland”, “venom”, “poison sack”. Database Study Sample Total Species name Systematic status Experiment Title Study Title Instrument Submitter source Accession Accession Size, Mb Crustacea The First Venomous Crustacean Revealed by Transcriptomics and Functional Xibalbanus (former Remipedia, 454 GS FLX SRX282054 454 Venom gland Transcriptome Speleonectes Morphology: Remipede Venom Glands Express a Unique Toxin Cocktail vReumont, NHM London SRP026153 SRR857228 639 Speleonectes ) tulumensis Speleonectidae Titanium Dominated by Enzymes and a Neurotoxin, MBE 2014, 31 (1) Hexapoda Diptera Total RNA isolated from Aedes aegypti salivary gland Normalized cDNA Instituto de Quimica - Aedes aegypti Culicidae dbEST Verjovski-Almeida,S., Eiglmeier,K., El-Dorry,H. etal, unpublished , 2005 Sanger dideoxy dbEST: 21107 Sequences library Universidade de Sao Paulo Centro de Investigacion Anopheles albimanus Culicidae dbEST Adult female Anopheles albimanus salivary gland cDNA library EST survey of the Anopheles albimanus transcriptome, 2007, unpublished Sanger dideoxy Sobre Enfermedades dbEST: 801 Sequences Infeccionsas, Mexico The salivary gland transcriptome of the neotropical malaria vector National Institute of Allergy Anopheles darlingii Culicidae dbEST Anopheles darlingi reveals accelerated evolution o genes relevant to BMC Genomics 10 (1): 57 2009 Sanger dideoxy dbEST: 2576 Sequences and Infectious Diseases hematophagyf An insight into the sialomes of Psorophora albipes, Anopheles dirus and An. Illumina HiSeq Anopheles dirus Culicidae SRX309996 Adult female Anopheles dirus salivary glands NIAID SRP026153 SRS448457 9453.44 freeborni 2000 An insight into the sialomes of Psorophora albipes, Anopheles dirus and An.
    [Show full text]
  • Zootaxa, Araneae, Agelenidae, Agelena
    Zootaxa 1021: 45–63 (2005) ISSN 1175-5326 (print edition) www.mapress.com/zootaxa/ ZOOTAXA 1021 Copyright © 2005 Magnolia Press ISSN 1175-5334 (online edition) On Agelena labyrinthica (Clerck, 1757) and some allied species, with descriptions of two new species of the genus Agelena from China (Araneae: Agelenidae) ZHI-SHENG ZHANG1,2*, MING-SHENG ZHU1** & DA-XIANG SONG1*** 1. College of Life Sciences, Hebei University, Baoding, Hebei 071002, P. R. China; 2. Baoding Teachers College, Baoding, Hebei 071051, P. R. China; *[email protected], **[email protected] (Corresponding author), ***[email protected] Abstract Seven allied species of the funnel-weaver spider genus Agelena Walckenaer, 1805, including the type species Agelena labyrinthica (Clerck, 1757), known to occur in Asia and Europe, are reviewed on the basis of the similarity of genital structures. Two new species are described: Agelena chayu sp. nov. and Agelena cuspidata sp. nov. The specific name A. silvatica Oliger, 1983 is revalidated. The female is newly described for A. injuria Fox, 1936. Two specific names are newly synony- mized: Agelena daoxianensis Peng, Gong et Kim, 1996 with A. silvatica Oliger, 1983, and A. sub- limbata Wang, 1991 with A. limbata Thorell, 1897. Some names are proposed for these species to represent some particular genital structures: conductor ventral apophysis, conductor median apo- physis, conductor distal apophysis and conductor dorsal apophysis for male palp and spermathecal head, spermathecal stalk, spermathecal base and spermathecal apophysis for female epigynum. Key words: genital structure, revalidation, synonym, review, taxonomy Introduction The funnel-weaver spider genus Agelena was erected by Walckenaer (1805) with the type species Araneus labyrinthicus Clerck, 1757.
    [Show full text]