DOCSLIB.ORG

In a Nutshell

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
In a Nutshell The European Bioinformatics Institute In a nutshell The European Bioinformatics Institute In a nutshell EMBL-European Bioinformatics Institute Wellcome Trust Genome Campus Hinxton, Cambridge CB10 1SD United Kingdom Web: www.ebi.ac.uk Tel: +44 (0)1223 494 444 Fax: +44 (0)1223 494 468 E-mail: [email protected] Twitter: @emblebi Facebook: /EMBLEBI Copyright © 2012 EMBL-EBI Photos courtesy of EMBL Photolab, Wellcome Images, Andrew Cowley and Samuel Kerrien. Find this and other EMBL-EBI publications at www.ebi.ac.uk/information/brochures The European Bioinformatics Institute In a nutshell The hub of bioinformatics in Europe 4 Who we are 6 Where we are 7 How we’re funded 7 Services 8 Research 10 Training 12 Supporting industry 13 European context 14 The hub of bioinformatics in Europe The European Bioinformatics Institute (EBI) is an academic research institute based in the UK, and is Our mission part of the European Molecular Biology Laboratory • To provide freely available data and (EMBL). Established in 1994, EMBL-EBI and grew bioinformatics services to all facets of the out of EMBL’s commitment to making biological scientific community in ways that promote data and information accessible to life scientists in all scientific progress disciplines. • To contribute to the advancement of biology We serve the scientific community by providing through basic investigator-driven research in freely available bioinformatics resources, promoting bioinformatics basic research, providing training to scientists at all • To provide advanced bioinformatics training levels and disseminating cutting-edge technologies to to scientists at all levels, from PhD students to industry. independent investigators We manage several large, public databases containing • To help disseminate cutting-edge biological data and information spanning genomics, technologies to industry gene expression, proteomics, structural biology, • To coordinate biological data provision cheminformatics, pathways and systems. We throughout Europe. create tools that allow researchers to analyse this information, and to upload and share their work. Because access to large data sets is a basic requirement for life science research, we provide user training on Strength through collaboration site, at host institutes throughout the world and in Our major data resources are the products of Train online, our free online training resource. We international collaborations. We work with other data also offer extensive training to our industry partners. providers to ensure that our data repositories, and those EMBL-EBI offers a top-quality research environment of our collaborators, are comprehensive and up to date. with countless opportunities for interdisciplinary For example: collaboration. The research we do helps to inform the • The European Nucleotide Archive (ENA) is services we provide, and vice versa. produced by the International Nucleotide Sequence Database Collaboration. The other partners are Why bioinformatics is important GenBank in the US and the DNA Databank of Japan. We define ‘bioinformatics’ as the application of • The UniProt databases contain protein sequence computer technology to the storage, management and and annotation data that is maintained cooperatively analysis of biological data. This is essential for research by three centres: EMBL-EBI, the SIB Swiss Institute in all areas of life science, such as health, agriculture, of Bioinformatics and the Protein Information biodiversity, energy and biotechnology. Resource in the US. The ultimate goal of bioinformatics is to identify • PDBe, our macromolecular structure database, is biologically meaningful information in experimental the European arm of the worldwide Protein Data data so that we can gain a better understanding of Bank (wwPDB). The other partners are the Research organisms on many different levels – from chemical Collaboratory for Structural Bioinformatics and the reactions to entire systems. Biological Magnetic Resonance Data Bank in the US Technologies such as DNA sequencing produce and the Protein Data Bank of Japan (PDBj). incredible amounts of new information every day. In • Ensembl, a joint project between EMBL-EBI and the fact, the volume of data generated in these experiments Wellcome Trust Sanger Institute, develops a software doubles every five months or so, while processor power system that produces and maintains automatic and storage double only every two years. annotation on selected eukaryotic genomes. But storage is only one part of the challenge. New • IntAct, our protein interactions resource, is a types of data are constantly emerging, and need to contributing database to the International Molecular be integrated with the old. We are always looking Exchange Consortium (IMEx). IMEx holds a non- for innovative ways to collect, store, retrieve and add redundant set of protein–protein interaction data value to biological data so that it can be analysed in from a broad taxonomic range of organisms. It is meaningful ways. funded by the European Commission. 4 www.ebi.ac.uk/information/brochures A unique working environment We share the Wellcome Trust Genome Campus in rural Cambridgeshire with the Wellcome Trust Sanger Institute, and are part of one of the world’s largest concentrations of expertise in genomics, bioinformatics and computational biology. The campus in Hinxton is set in 22 hectares of parkland on the banks of the river Cam. We have the advantage of being housed in modern buildings in a beautiful setting, whilst being only a few miles away from the academic centre of Cambridge. The campus provides an inspiring environment for all staff. We are regularly visited by some of the greatest minds in biomedical research, and the workshops, seminars and conferences held on campus are open to all staff. Our personnel, including long-term visiting scholars, hail from 48 different countries. This chart shows the nationalities of our members of staff as of December 2011. We have excellent computational facilities and a comprehensive library. The campus also enjoys a highly active social life, with events held on campus throughout the year and all manner of sports teams. We have a gym, a choice of places to eat, and free transport by shuttle bus to Cambridge, Saffron Walden and some of the surrounding villages. If you would like to visit EMBL-EBI, you can register for one of our Open Days, which we hold twice a year. www.ebi.ac.uk/training/openday For information about getting to the campus, please see the inside back cover. Setting standards We actively participate in international efforts to develop data standards, which are essential for ensuring the accuracy of the scientific record. For example, EMBL-EBI was a leading partner in developing the MIAME standard, which sets out the minimum information required to describe a microarray experiment in a published article. The MIABE standard, published in collaboration with our Industry Programme partners, describes the minimum information required to describe a bioactive entity. Another example is the Human Proteome Organisa- tion’s Proteomics Standards Initiative (PSI), which develops standards for data from experiments involv- ing molecular interactions, mass spectrometry, pro- tein separations, protein modifications and protein informatics. www.ebi.ac.uk/information/brochures 5 Leadership Janet Thornton Rolf Apweiler Ewan Birney Director Co-Associate Director Co-Associate Director Professor Dame Janet Thornton has been Director Ewan Birney has had strategic responsibility and of EMBL-EBI since October 2001. Her research oversight for all nucleotide databases at EMBL-EBI, group focuses on understanding biological including the Ensembl genome browser for verte- processes from a structural perspective using brate species, Ensembl Genomes for non-vertebrate computational approaches. After a physics degree, species and the European Nucleotide Archive (ENA), she moved into biophysics at the National Institute major sequence resource. Ewan played a vital role for Medical Research, Mill Hill, London. Before in annotating the genome sequences of the human, moving to EMBL-EBI she held a joint appointment mouse, chicken and several other organisms; this at University College London and the Bernal Chair work has had a profound impact on our understand- in the Crystallography Department at Birkbeck ing of genomic biology. He currently leads the analy- College. She is a Fellow of the Royal Society, a sis group for the ENCODE project, which is defining Member of EMBO and a foreign associate of the US functional elements in the human genome. Ewan is National Academy of Sciences. one of the founders of the Ensembl genome browser, and is an active researcher in a number of areas. He Rolf Apweiler and Ewan Birney took on the completed his PhD at the Wellcome Trust Sanger Associate Directorship of EMBL-EBI in 2012, and Institute, and has been at EMBL-EBI since 2000. have strategic oversight of our core resources. They follow in the footsteps of Graham Cameron, who played a key role in launching EMBL-EBI and was responsible for our bioinformatics services until his retirement in March 2012. Rolf has been responsible for vital protein and pro- teomics reference databases at EMBL-EBI, including the Universal Protein Resource (UniProt), a joint ef- fort with the SIB Swiss Institute of Bioinformatics and the Protein Information Resource in the US; InterPro, for cataloguing protein families and domains; PRIDE experimental proteomics data; IntAct, for molecular
Load more

Recommended publications
  • Ensembl Genomes: Extending Ensembl Across the Taxonomic Space P
    Published online 1 November 2009 Nucleic Acids Research, 2010, Vol. 38, Database issue D563–D569 doi:10.1093/nar/gkp871 Ensembl Genomes: Extending Ensembl across the taxonomic space P. J. Kersey*, D. Lawson, E. Birney, P. S. Derwent, M. Haimel, J. Herrero, S. Keenan, A. Kerhornou, G. Koscielny, A. Ka¨ ha¨ ri, R. J. Kinsella, E. Kulesha, U. Maheswari, K. Megy, M. Nuhn, G. Proctor, D. Staines, F. Valentin, A. J. Vilella and A. Yates EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK Received August 14, 2009; Revised September 28, 2009; Accepted September 29, 2009 ABSTRACT nucleotide archives; numerous other genomes exist in states of partial assembly and annotation; thousands of Ensembl Genomes (http://www.ensemblgenomes viral genomes sequences have also been generated. .org) is a new portal offering integrated access to Moreover, the increasing use of high-throughput genome-scale data from non-vertebrate species sequencing technologies is rapidly reducing the cost of of scientific interest, developed using the Ensembl genome sequencing, leading to an accelerating rate of genome annotation and visualisation platform. data production. This not only makes it likely that in Ensembl Genomes consists of five sub-portals (for the near future, the genomes of all species of scientific bacteria, protists, fungi, plants and invertebrate interest will be sequenced; but also the genomes of many metazoa) designed to complement the availability individuals, with the possibility of providing accurate and of vertebrate genomes in Ensembl. Many of the sophisticated annotation through the similarly low-cost databases supporting the portal have been built in application of functional assays.
    [Show full text]
  • Gene Prediction: the End of the Beginning Comment Colin Semple
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central http://genomebiology.com/2000/1/2/reports/4012.1 Meeting report Gene prediction: the end of the beginning comment Colin Semple Address: Department of Medical Sciences, Molecular Medicine Centre, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. E-mail: [email protected] Published: 28 July 2000 reviews Genome Biology 2000, 1(2):reports4012.1–4012.3 The electronic version of this article is the complete one and can be found online at http://genomebiology.com/2000/1/2/reports/4012 © GenomeBiology.com (Print ISSN 1465-6906; Online ISSN 1465-6914) Reducing genomes to genes reports A report from the conference entitled Genome Based Gene All ab initio gene prediction programs have to balance sensi- Structure Determination, Hinxton, UK, 1-2 June, 2000, tivity against accuracy. It is often only possible to detect all organised by the European Bioinformatics Institute (EBI). the real exons present in a sequence at the expense of detect- ing many false ones. Alternatively, one may accept only pre- dictions scoring above a more stringent threshold but lose The draft sequence of the human genome will become avail- those real exons that have lower scores. The trick is to try and able later this year. For some time now it has been accepted increase accuracy without any large loss of sensitivity; this deposited research that this will mark a beginning rather than an end. A vast can be done by comparing the prediction with additional, amount of work will remain to be done, from detailing independent evidence.
    [Show full text]
  • Abstracts Genome 10K & Genome Science 29 Aug - 1 Sept 2017 Norwich Research Park, Norwich, Uk
    Genome 10K c ABSTRACTS GENOME 10K & GENOME SCIENCE 29 AUG - 1 SEPT 2017 NORWICH RESEARCH PARK, NORWICH, UK Genome 10K c 48 KEYNOTE SPEAKERS ............................................................................................................................... 1 Dr Adam Phillippy: Towards the gapless assembly of complete vertebrate genomes .................... 1 Prof Kathy Belov: Saving the Tasmanian devil from extinction ......................................................... 1 Prof Peter Holland: Homeobox genes and animal evolution: from duplication to divergence ........ 2 Dr Hilary Burton: Genomics in healthcare: the challenges of complexity .......................................... 2 INVITED SPEAKERS ................................................................................................................................. 3 Vertebrate Genomics ........................................................................................................................... 3 Alex Cagan: Comparative genomics of animal domestication .......................................................... 3 Plant Genomics .................................................................................................................................... 4 Ksenia Krasileva: Evolution of plant Immune receptors ..................................................................... 4 Andrea Harper: Using Associative Transcriptomics to predict tolerance to ash dieback disease in European ash trees ............................................................................................................
    [Show full text]
  • SD Gross BFI0403
    Janet Thornton Bioinformatician avant la lettre Michael Gross B ioinformatics is very much a buzzword of our time, with new courses and institutes dedicated to it sprouting up almost everywhere. Most significantly, the flood of genome data has raised the gen- eral awareness of the need to deve-lop new computational approaches to make sense of all the raw information collected. Professor Janet Thornton, the current director of the European Bioinformatics Institute (EBI), an EMBL outpost based at the Hinxton campus near Cambridge, has been in the field even before there was a word for it. Coming to structural biology with a physics degree from the University of Nottingham, she was already involved with computer-generated structural im- ages in the 1970s, when personal comput- ers and user-friendly programs had yet to be invented. The Early Years larities. Within 15 minutes, the software From there to the EBI, her remarkable Janet Thornton can check all 2.4 billion possible re- career appears to be organised in lationships and pick the ones relevant decades. During the 1970s, she did doc- software to compare structures to each to the question at hand. In comparison toral and post-doctoral research at other, recognise known folds and spot to publicly available bioinformatics the Molecular Biophysics Laboratory in new ones. Such work provides both packages such as Blast or Psiblast, Oxford and at the National Institute for fundamental insights into the workings Biopendium can provide an additional Medical Research in Mill Hill, near Lon- of evolution on a molecular level, and 30 % of annotation, according to Inphar- don.
    [Show full text]
  • The EMBL-European Bioinformatics Institute the Hub for Bioinformatics in Europe
    The EMBL-European Bioinformatics Institute The hub for bioinformatics in Europe Blaise T.F. Alako, PhD [email protected] www.ebi.ac.uk What is EMBL-EBI? • Part of the European Molecular Biology Laboratory • International, non-profit research institute • Europe’s hub for biological data, services and research The European Molecular Biology Laboratory Heidelberg Hamburg Hinxton, Cambridge Basic research Structural biology Bioinformatics Administration Grenoble Monterotondo, Rome EMBO EMBL staff: 1500 people Structural biology Mouse biology >60 nationalities EMBL member states Austria, Belgium, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom Associate member state: Australia Who we are ~500 members of staff ~400 work in services & support >53 nationalities ~120 focus on basic research EMBL-EBI’s mission • Provide freely available data and bioinformatics services to all facets of the scientific community in ways that promote scientific progress • Contribute to the advancement of biology through basic investigator-driven research in bioinformatics • Provide advanced bioinformatics training to scientists at all levels, from PhD students to independent investigators • Help disseminate cutting-edge technologies to industry • Coordinate biological data provision throughout Europe Services Data and tools for molecular life science www.ebi.ac.uk/services Browse our services 9 What services do we provide? Labs around the
    [Show full text]
  • Functional Effects Detailed Research Plan
    GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data.
    [Show full text]
  • Meeting Review: Bioinformatics and Medicine – from Molecules To
    Comparative and Functional Genomics Comp Funct Genom 2002; 3: 270–276. Published online 9 May 2002 in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/cfg.178 Feature Meeting Review: Bioinformatics And Medicine – From molecules to humans, virtual and real Hinxton Hall Conference Centre, Genome Campus, Hinxton, Cambridge, UK – April 5th–7th Roslin Russell* MRC UK HGMP Resource Centre, Genome Campus, Hinxton, Cambridge CB10 1SB, UK *Correspondence to: Abstract MRC UK HGMP Resource Centre, Genome Campus, The Industrialization Workshop Series aims to promote and discuss integration, automa- Hinxton, Cambridge CB10 1SB, tion, simulation, quality, availability and standards in the high-throughput life sciences. UK. The main issues addressed being the transformation of bioinformatics and bioinformatics- based drug design into a robust discipline in industry, the government, research institutes and academia. The latest workshop emphasized the influence of the post-genomic era on medicine and healthcare with reference to advanced biological systems modeling and simulation, protein structure research, protein-protein interactions, metabolism and physiology. Speakers included Michael Ashburner, Kenneth Buetow, Francois Cambien, Cyrus Chothia, Jean Garnier, Francois Iris, Matthias Mann, Maya Natarajan, Peter Murray-Rust, Richard Mushlin, Barry Robson, David Rubin, Kosta Steliou, John Todd, Janet Thornton, Pim van der Eijk, Michael Vieth and Richard Ward. Copyright # 2002 John Wiley & Sons, Ltd. Received: 22 April 2002 Keywords: bioinformatics;
    [Show full text]
  • Rare Variant Contribution to Human Disease in 281,104 UK Biobank Exomes W ­ 1,19 1,19 2,19 2 2 Quanli Wang , Ryan S
    https://doi.org/10.1038/s41586-021-03855-y Accelerated Article Preview Rare variant contribution to human disease W in 281,104 UK Biobank exomes E VI Received: 3 November 2020 Quanli Wang, Ryan S. Dhindsa, Keren Carss, Andrew R. Harper, Abhishek N ag­­, I oa nn a Tachmazidou, Dimitrios Vitsios, Sri V. V. Deevi, Alex Mackay, EDaniel Muthas, Accepted: 28 July 2021 Michael Hühn, Sue Monkley, Henric O ls so n , S eb astian Wasilewski, Katherine R. Smith, Accelerated Article Preview Published Ruth March, Adam Platt, Carolina Haefliger & Slavé PetrovskiR online 10 August 2021 P Cite this article as: Wang, Q. et al. Rare variant This is a PDF fle of a peer-reviewed paper that has been accepted for publication. contribution to human disease in 281,104 UK Biobank exomes. Nature https:// Although unedited, the content has been subjectedE to preliminary formatting. Nature doi.org/10.1038/s41586-021-03855-y (2021). is providing this early version of the typeset paper as a service to our authors and Open access readers. The text and fgures will undergoL copyediting and a proof review before the paper is published in its fnal form. Please note that during the production process errors may be discovered which Ccould afect the content, and all legal disclaimers apply. TI R A D E T A R E L E C C A Nature | www.nature.com Article Rare variant contribution to human disease in 281,104 UK Biobank exomes W 1,19 1,19 2,19 2 2 https://doi.org/10.1038/s41586-021-03855-y Quanli Wang , Ryan S.
    [Show full text]
  • The ELIXIR Core Data Resources: ​Fundamental Infrastructure for The
    Supplementary Data: The ELIXIR Core Data Resources: fundamental infrastructure ​ for the life sciences The “Supporting Material” referred to within this Supplementary Data can be found in the Supporting.Material.CDR.infrastructure file, DOI: 10.5281/zenodo.2625247 (https://zenodo.org/record/2625247). ​ ​ Figure 1. Scale of the Core Data Resources Table S1. Data from which Figure 1 is derived: Year 2013 2014 2015 2016 2017 Data entries 765881651 997794559 1726529931 1853429002 2715599247 Monthly user/IP addresses 1700660 2109586 2413724 2502617 2867265 FTEs 270 292.65 295.65 289.7 311.2 Figure 1 includes data from the following Core Data Resources: ArrayExpress, BRENDA, CATH, ChEBI, ChEMBL, EGA, ENA, Ensembl, Ensembl Genomes, EuropePMC, HPA, IntAct /MINT , InterPro, PDBe, PRIDE, SILVA, STRING, UniProt ● Note that Ensembl’s compute infrastructure physically relocated in 2016, so “Users/IP address” data are not available for that year. In this case, the 2015 numbers were rolled forward to 2016. ● Note that STRING makes only minor releases in 2014 and 2016, in that the interactions are re-computed, but the number of “Data entries” remains unchanged. The major releases that change the number of “Data entries” happened in 2013 and 2015. So, for “Data entries” , the number for 2013 was rolled forward to 2014, and the number for 2015 was rolled forward to 2016. The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences ​ 1 Figure 2: Usage of Core Data Resources in research The following steps were taken: 1. API calls were run on open access full text articles in Europe PMC to identify articles that ​ ​ mention Core Data Resource by name or include specific data record accession numbers.
    [Show full text]
  • (DDD) Project: What a Genomic Approach Can Achieve
    The Deciphering Development Disorders (DDD) project: What a genomic approach can achieve RCP ADVANCED MEDICINE, LONDON FEB 5TH 2018 HELEN FIRTH DM FRCP DCH, SANGER INSTITUTE 3,000,000,000 bases in each human genome Disease & developmental Health & development disorders Fascinating facts about your genome! –~20,000 protein-coding genes –~30% of genes have a known role in disease or developmental disorders –~10,000 protein altering variants –~100 protein truncating variants –~70 de novo mutations (~1-2 coding ie. In exons of genes) Rare Disease affects 1 in 17 people •Prior to DDD, diagnostic success in patients with rare paediatric disease was poor •Not possible to diagnose many patients with current methodology in routine use– maximum benefit in this group •DDD recruited patients with severe/extreme clinical features present from early childhood with high expectation of genetic basis •Recruitment was primarily of trios (ie The Doctor Sir Luke Fildes (1887) child and both parents) ~ 90% Making a genomic diagnosis of a rare disease improves care •Accurate diagnosis is the cornerstone of good medical practice – informing management, treatment, prognosis and prevention •Enables risk to other family members to be determined enabling predictive testing with potential for surveillance and therapy in some disorders February 28th 2018 •Reduces sense of isolation, enabling better access to support and information •Curtails the diagnostic odyssey •Not just a descriptive label; identifies the fundamental cause of disease A genomic diagnosis can be a gateway to better treatment •Not just a descriptive label; identifies the fundamental cause of disease •Biallelic mutations in the CFTR gene cause Cystic Fibrosis • CFTR protein is an epithelial ion channel regulating absorption/ secretion of salt and water in the lung, sweat glands, pancreas & GI tract.
    [Show full text]
  • Different Evolutionary Patterns of Snps Between Domains and Unassigned Regions in Human Protein‑Coding Sequences
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Springer - Publisher Connector Mol Genet Genomics (2016) 291:1127–1136 DOI 10.1007/s00438-016-1170-7 ORIGINAL ARTICLE Different evolutionary patterns of SNPs between domains and unassigned regions in human protein‑coding sequences Erli Pang1 · Xiaomei Wu2 · Kui Lin1 Received: 14 September 2015 / Accepted: 18 January 2016 / Published online: 30 January 2016 © The Author(s) 2016. This article is published with open access at Springerlink.com Abstract Protein evolution plays an important role in Furthermore, the selective strength on domains is signifi- the evolution of each genome. Because of their functional cantly greater than that on unassigned regions. In addition, nature, in general, most of their parts or sites are differently among all of the human protein sequences, there are 117 constrained selectively, particularly by purifying selection. PfamA domains in which no SNPs are found. Our results Most previous studies on protein evolution considered indi- highlight an important aspect of protein domains and may vidual proteins in their entirety or compared protein-coding contribute to our understanding of protein evolution. sequences with non-coding sequences. Less attention has been paid to the evolution of different parts within each pro- Keywords Human genome · Protein-coding sequence · tein of a given genome. To this end, based on PfamA anno- Protein domain · SNPs · Natural selection tation of all human proteins, each protein sequence can be split into two parts: domains or unassigned regions. Using this rationale, single nucleotide polymorphisms (SNPs) in Introduction protein-coding sequences from the 1000 Genomes Project were mapped according to two classifications: SNPs occur- Studying protein evolution is crucial for understanding ring within protein domains and those within unassigned the evolution of speciation and adaptation, senescence and regions.
    [Show full text]
  • Annual Scientific Report 2013 on the Cover Structure 3Fof in the Protein Data Bank, Determined by Laponogov, I
    EMBL-European Bioinformatics Institute Annual Scientific Report 2013 On the cover Structure 3fof in the Protein Data Bank, determined by Laponogov, I. et al. (2009) Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nature Structural & Molecular Biology 16, 667-669. © 2014 European Molecular Biology Laboratory This publication was produced by the External Relations team at the European Bioinformatics Institute (EMBL-EBI) A digital version of the brochure can be found at www.ebi.ac.uk/about/brochures For more information about EMBL-EBI please contact: [email protected] Contents Introduction & overview 3 Services 8 Genes, genomes and variation 8 Molecular atlas 12 Proteins and protein families 14 Molecular and cellular structures 18 Chemical biology 20 Molecular systems 22 Cross-domain tools and resources 24 Research 26 Support 32 ELIXIR 36 Facts and figures 38 Funding & resource allocation 38 Growth of core resources 40 Collaborations 42 Our staff in 2013 44 Scientific advisory committees 46 Major database collaborations 50 Publications 52 Organisation of EMBL-EBI leadership 61 2013 EMBL-EBI Annual Scientific Report 1 Foreword Welcome to EMBL-EBI’s 2013 Annual Scientific Report. Here we look back on our major achievements during the year, reflecting on the delivery of our world-class services, research, training, industry collaboration and European coordination of life-science data. The past year has been one full of exciting changes, both scientifically and organisationally. We unveiled a new website that helps users explore our resources more seamlessly, saw the publication of ground-breaking work in data storage and synthetic biology, joined the global alliance for global health, built important new relationships with our partners in industry and celebrated the launch of ELIXIR.
    [Show full text]