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Home , 1000 Genomes Project, ChEMBL, Ensembl Genomes, Ewan Birney, Janet Thornton, Protein Data Bank

The European Institute In a nutshell

The European Bioinformatics Institute In a nutshell EMBL-European Bioinformatics Institute Campus Hinxton, Cambridge CB10 1SD

Web: www.ebi.ac.uk

Tel: +44 (0)1223 494 444 Fax: +44 (0)1223 494 468 E-mail: [email protected] : @emblebi Facebook: /EMBLEBI Copyright © 2012 EMBL-EBI Photos courtesy of EMBL Photolab, Wellcome Images, Andrew Cowley and Samuel Kerrien. Find this and other EMBL-EBI publications at www.ebi.ac.uk/information/brochures The European Bioinformatics Institute In a nutshell

The hub of bioinformatics in 4 Who we are 6 Where we are 7 How we’re funded 7 Services 8 Research 10 Training 12 Supporting industry 13 European context 14 The hub of bioinformatics in Europe

The European Bioinformatics Institute (EBI) is an academic research institute based in the UK, and is Our mission part of the European Molecular Biology Laboratory • To provide freely available data and (EMBL). Established in 1994, EMBL-EBI and grew bioinformatics services to all facets of the out of EMBL’s commitment to making biological scientific community in ways that promote data and information accessible to life scientists in all scientific progress disciplines. • To contribute to the advancement of biology We serve the scientific community by providing through basic investigator-driven research in freely available bioinformatics resources, promoting bioinformatics basic research, providing training to scientists at all • To provide advanced bioinformatics training levels and disseminating cutting-edge technologies to to scientists at all levels, from PhD students to industry. independent investigators We manage several large, public databases containing • To help disseminate cutting-edge biological data and information spanning , technologies to industry expression, , , • To coordinate biological data provision cheminformatics, pathways and systems. We throughout Europe. create tools that allow researchers to analyse this information, and to upload and share their work. Because access to large data sets is a basic requirement for life research, we provide user training on Strength through collaboration site, at host institutes throughout the world and in Our major data resources are the products of Train online, our free online training resource. We international collaborations. We work with other data also offer extensive training to our industry partners. providers to ensure that our data repositories, and those EMBL-EBI offers a top-quality research environment of our collaborators, are comprehensive and up to date. with countless opportunities for interdisciplinary For example: collaboration. The research we do helps to inform the • The European Nucleotide Archive (ENA) is services we provide, and vice versa. produced by the International Nucleotide Collaboration. The other partners are Why bioinformatics is important GenBank in the US and the DNA Databank of . We define ‘bioinformatics’ as the application of • The UniProt databases contain sequence computer technology to the storage, management and and annotation data that is maintained cooperatively analysis of biological data. This is essential for research by three centres: EMBL-EBI, the SIB Swiss Institute in all areas of life science, such as health, agriculture, of Bioinformatics and the Protein Information biodiversity, energy and biotechnology. Resource in the US. The ultimate goal of bioinformatics is to identify • PDBe, our macromolecular structure database, is biologically meaningful information in experimental the European arm of the worldwide Protein Data data so that we can gain a better understanding of Bank (wwPDB). The other partners are the Research on many different levels – from chemical Collaboratory for Structural Bioinformatics and the reactions to entire systems. Biological Magnetic Resonance Data Bank in the US Technologies such as DNA produce and the Protein Data Bank of Japan (PDBj). incredible amounts of new information every day. In • Ensembl, a joint project between EMBL-EBI and the fact, the volume of data generated in these experiments Wellcome Trust Sanger Institute, develops a software doubles every five months or so, while processor power system that produces and maintains automatic and storage double only every two years. annotation on selected eukaryotic . But storage is only one part of the challenge. New • IntAct, our protein interactions resource, is a types of data are constantly emerging, and need to contributing database to the International Molecular be integrated with the old. We are always looking Exchange Consortium (IMEx). IMEx holds a non- for innovative ways to collect, store, retrieve and add redundant set of protein–protein interaction data value to biological data so that it can be analysed in from a broad taxonomic range of organisms. It is meaningful ways. funded by the European Commission.

4 www.ebi.ac.uk/information/brochures A unique working environment We share the Wellcome Trust Genome Campus in rural Cambridgeshire with the Wellcome Trust Sanger Institute, and are part of one of the world’s largest concentrations of expertise in genomics, bioinformatics and . The campus in Hinxton is set in 22 hectares of parkland on the banks of the river Cam. We have the advantage of being housed in modern buildings in a beautiful setting, whilst being only a few miles away from the academic centre of Cambridge. The campus provides an inspiring environment for all staff. We are regularly visited by some of the greatest minds in biomedical research, and the workshops, seminars and conferences held on campus are open to all staff. Our personnel, including long-term visiting scholars, hail from 48 different countries. This chart shows the nationalities of our members of staff as of December 2011.

We have excellent computational facilities and a comprehensive library. The campus also enjoys a highly active social life, with events held on campus throughout the year and all manner of sports teams. We have a gym, a choice of places to eat, and free transport by shuttle bus to Cambridge, Saffron Walden and some of the surrounding villages. If you would like to visit EMBL-EBI, you can register for one of our Open Days, which we hold twice a year. www.ebi.ac.uk/training/openday For information about getting to the campus, please see the inside back cover.

Setting standards We actively participate in international efforts to develop data standards, which are essential for ensuring the accuracy of the scientific record. For example, EMBL-EBI was a leading partner in developing the MIAME standard, which sets out the minimum information required to describe a microarray experiment in a published article. The MIABE standard, published in collaboration with our Industry Programme partners, describes the minimum information required to describe a bioactive entity. Another example is the Proteome Organisa- tion’s Proteomics Standards Initiative (PSI), which develops standards for data from experiments involv- ing molecular interactions, mass spectrometry, pro- tein separations, protein modifications and protein informatics.

www.ebi.ac.uk/information/brochures 5 Leadership

Janet Thornton Director Co-Associate Director Co-Associate Director

Professor Dame has been Director Ewan Birney has had strategic responsibility and of EMBL-EBI since October 2001. Her research oversight for all nucleotide databases at EMBL-EBI, group focuses on understanding biological including the Ensembl genome browser for verte- processes from a structural perspective using brate , for non-vertebrate computational approaches. After a physics degree, species and the European Nucleotide Archive (ENA), she moved into at the National Institute major sequence resource. Ewan played a vital role for Medical Research, Mill Hill, . Before in annotating the genome sequences of the human, moving to EMBL-EBI she held a joint appointment mouse, chicken and several other organisms; this at University College London and the Bernal Chair work has had a profound impact on our understand- in the Department at Birkbeck ing of genomic biology. He currently leads the analy- College. She is a of the Royal Society, a sis group for the ENCODE project, which is defining Member of EMBO and a foreign associate of the US functional elements in the . Ewan is National Academy of Sciences. one of the founders of the Ensembl genome browser, and is an active researcher in a number of areas. He Rolf Apweiler and Ewan Birney took on the completed his PhD at the Wellcome Trust Sanger Associate Directorship of EMBL-EBI in 2012, and Institute, and has been at EMBL-EBI since 2000. have strategic oversight of our core resources. They follow in the footsteps of Graham Cameron, who played a key role in launching EMBL-EBI and was responsible for our bioinformatics services until his retirement in March 2012. Rolf has been responsible for vital protein and pro- teomics reference databases at EMBL-EBI, including the Universal Protein Resource (UniProt), a joint ef- fort with the SIB Swiss Institute of Bioinformatics and the Protein Information Resource in the US; InterPro, for cataloguing protein families and domains; PRIDE experimental proteomics data; IntAct, for molecular interaction data; and EMBL-EBI’s contribution to the . Rolf has made a major contribution to methods for the automatic annotation of , and his team has led in the development of standards for proteomics data. Rolf received his PhD from the University of Heidelberg in 1994, and has been at EMBL since 1987.

6 www.ebi.ac.uk/information/brochures Part of the European Molecular Biology Laboratory Hinxton: European Bioinformatics Institute EMBL is one of the world’s leading research institutions, and is Europe’s flagship laboratory for the life sciences. EMBL is an inter-governmental organisation funded by public research monies from 20 member states: Austria, Belgium, Croatia, Denmark, , France, Germany, Greece, Iceland, Ireland, Israel, , Luxembourg, the Netherlands, Norway, Portugal, , Sweden, Switzerland and the United Kingdom, and associate Hamburg: research member state Australia. and services for structural biology Research at EMBL is conducted by approximately 85 independent groups covering the spectrum of Heidelberg: main molecular biology. The main laboratory is located in laboratory Heidelberg, Germany. In addition to EMBL-EBI in Hinxton, EMBL has outstations in Monterotondo, Italy, Grenoble, France and Hamburg, Germany.

EMBL’s Director General is Professor , and its governing body, EMBL Council, is composed of representatives of all member and associate member states. Monterotondo: mouse EMBL’s mission is to: perform basic research in biology programme molecular biology; train scientists, students and visitors at all levels; offer vital services to scientists Grenoble: research and in the member states; develop new instruments and services for structural methods; and engage actively in technology transfer. biology How we are funded

As part of EMBL, the largest part of our funding comes from the governments of EMBL’s member states. The global importance of our work is reflected in the fact that we also attract significant funds from external sources, including some beyond Europe. Some of our other major funders include the US National Institutes of Health, the European Commission, the Wellcome Trust, UK Research Councils and our industry partners. The UK’s Biotechnology and Biological Sciences Research Council (BBSRC) awarded approximately €87.5m (£75m) in December 2011, in addition to €11.4m in August 2009, in support of EMBL-EBI’s planned role as the central hub of ELIXIR. These funds will be used to further develop a robust compute infrastructure that will allow the EBI to manage an ever-expanding and diversifying range of EMBL-EBI receives most of its funding from EMBL’s 20 member services, and to build a new ‘technical hub’ building states. In addition, we receive funding from outside sources, shown housing 200 people. here for 2011.

www.ebi.ac.uk/information/brochures 7 Search www.ebi.ac.uk

Genomes Ensembl: Browse and compare vertebrate genomes. Ensembl is a collaboration between EMBL-EBI and the Wellcome Trust Sanger Institute. Ensembl Genomes: Explore non-vertebrate genomes, including and prokaryotes. EGA: The European Genome–phenome Archive contains information on individual human genotypes. Metagenomics portal: An automated pipeline for the analysis and archiving of metagenomic data.

Nucleotide sequence ENA: Find any DNA or RNA sequence in the public domain, including completed genomes and sequences associated with patents.

Functional Genomics ArrayExpress Archive: Access annotated microarray experiments. Atlas: Contains a subset of curated and re- annotated data from ArrayExpress, which can be used to search gene expression under different biological conditions.

Principles of service provision Protein families, domains and motifs Accessibility – Our data and tools are freely InterPro: Perform integrated searches for protein families, available to the research community without motifs and domains. InterPro combines the strength of 11 restriction. The only exception is potentially member databases to yield a powerful resource for large- identifiable human genetic information, for scale protein classification and annotation. which access depends on research consent agreements. Pathways Compatibility – We are a world leader in promoting the adoption of standards in Reactome: Navigate a map of human biological pathways, bioinformatics. ranging from metabolic processes to hormonal signalling. MetaboLights: Explore Metabolomics experiments and Quality – Our databases are enhanced derived information: metabolite structures, reference through annotation: information is added to spectra, biological roles, locations and concentrations. the original data to provide context and help with interpretation. Much of our annotation is performed by highly qualified , and the automated annotation that we do is subjected to rigorous quality control.

Portability – Many of our data sets are made Services available for download from the EMBL-EBI website. In many cases the entire software We maintain the world’s most comprehensive range of molecular system can be downloaded and installed databases, and are the European node for globally coordinated locally. efforts to collect and disseminate biologically relevant data.

Comprehensive data sets – We share data to Many of our databases are household names to biologists and ensure that our resources are comprehensive biochemists, such as the European Nucleotide Archive (ENA), and up to date. We also work with publishers Ensembl, ArrayExpress, UniProt, PDBe and InterPro. All of our to ensure that biological data are placed in databases uphold the same principles of service provision (see a public repository as part of the publication process and cross-referenced in the relevant box). We are the custodians of biological data submitted by the publication. community and provide unrestricted to these data.

8 www.ebi.ac.uk/information/brochures Literature CiteXplore: Search the scientific literature and automatically add links to biological data resources. GO: The Gene Ontology project aims to produce an unambiguous, universal language to describe biological phenomena across all species. UKPMC: A unique, innovative and free online resource offering access to information sources for biomedical and health researchers.

Protein sequence UniProt: The world’s most comprehensive catalogue of information on proteins – to gain user-friendly access to richly annotated information on individual proteins, and to full proteome sets. Macromolecular structure PDBe: Contains the Protein Data Bank’s structures. View predicted quaternary structures, interactions with ligands and structure comparisons.

Protein activity IntAct: Access information on protein–protein interactions. Build graphical views of interaction networks and annotate them with functional information. PRIDE: A centralised public data repository for proteomics data, including information on post-translational modifications.

Chemical entities ChEBI: Bridge the gap between the protein world and that of small molecules. Portal: Integrates enzyme information such as small-molecule chemistry, biochemical pathways and drug compounds.

Chemogenomics ChEMBL: Explore structure–activity relationships of drugs and drug-like molecules.

Systems BioModels: Search and retrieve published mathematical models of biological interest. Models are annotated and linked to relevant data resources.

Our website (www.ebi.ac.uk), which receives more than Supporting our users 4 million requests a day, provides direct access to all our databases and tools. To help you make the most of our resources, you can reach our entire support team through our website (www.ebi. The EBI search provides easy access to our data, allowing ac.uk/help). A member of the team will get back to your you to explore our many resources from a simple results request within two working days. summary. Our tools allow you to submit your own data, perform complex queries across multiple databases, analyse data and view the results in different ways. You can download data and software fromftp://ftp.ebi.ac.uk , and access a growing number of our resources programmatically using web services.

www.ebi.ac.uk/information/brochures 9 Research

We provide a unique environment for bioinformatics research, and our broad palette of research interests complements our data resources. EMBL-EBI researchers have the expertise of hundreds of bioinformaticians close at hand – even in the lunch queue or on the volleyball pitch. Our research groups develop new approaches to interpreting biological data. Our services teams develop and maintain our resources but also perform research.

Genomics which biological features add most to the accuracy Ewan Birney: Nucleotide of the models, they hope to find out which proposed evolutionary forces are responsible for the patterns of data resources sequence variation within and among species. Ewan has been responsible for all nucleotide sequence Transcriptomics resources at EMBL-EBI, and led the analysis of the ENCODE Alvis Brazma: Functional project. His group’s research genomics focuses on developing sequence and using intra-species variation to study basic biology. Future Alvis’s team is responsible projects involve developing algorithms to study for the development of the segmental duplication and to expand intra-species ArrayExpress Archive and Gene variation studies to other basic biological Expression Atlas resources for in other species. gene expression and related functional genomics data. The group’s research focuses on analysis of gene expression, development of new Paul Flicek: Vertebrate algorithms and methods for integrative data analysis, genomics and building a global map of gene expression. They also investigate the relationship between gene Paul’s team is a combined expression and disease. service and research group that brings together the tools and resources of the Ensembl Anton Enright: RNA genome analysis framework genomics for , variation and functional Anton’s group has a particular genomics. The team also develops the large-scale interest in small non- bioinformatics infrastructure for human variation coding RNAs and develops projects such as the and European computational tools, systems Genome-phenome Archive (EGA) as a first step towards and algorithms to predict the annotating all human variation. Their research involves function and interactions of small RNAs. The group exploring the of transcriptional regulation and collaborates extensively with experimental labs developing algorithms to study epigenomic data. in order to build better data sets for helping us to understand these important regulatory molecules. : They also have interests in the visualisation of large Evolutionary analysis of data sets, graph-clustering and analysis of biological sequence data networks. Nick’s group is developing John Marioni: improved mathematical Computational and and statistical methods for evolutionary genomics analysing DNA and sequences to study how these John’s group develops sequences evolve. The team uses information from computational and statistical evolutionary studies to increase the accuracy of other methods to better understand data analyses in bioinformatics, including the use of how changes in genetic next-generation sequencing technology. By seeing architecture (e.g. the relationship between sequence and gene expression) provide insights into the

10 www.ebi.ac.uk/information/brochures adaptive evolution of complex organisms and Pathways and systems developmental processes. They also develop methods for storing, visualising and analysing genetic features Paul Bertone: at a single-cell level to improve our understanding of both key developmental processes and neural function Differentiation and in an evolutionary context. development Paul’s group investigates the Proteins and structures cellular and molecular processes underlying mammalian stem- Janet Thornton: Proteins cell differentiation and induced – structure, function and pluripotency. One strand of their research is to map the transition between the pluripotent state and early evolution lineage commitment. The group will also work to Janet’s research group aims to further characterise the molecular properties of neural understand more about the cancer stem cells and assess the role of genetic changes three-dimensional structure across individuals. and evolution of proteins. For example, they analyse how perform Nicolas Le Novère: catalysis, how these molecules recognise their Computational systems cognate ligands, how proteins and organisms have evolved to create life, and the modelling of the biology signalling pathway in ageing. Much of their research Nicolas’s group aims to gain a is collaborative, involving either experimentalists or better understanding of signal other computational biologists. transduction in neurons by building computational models. They plan to expand their research activities to Chemistry incorporate whole neuron behaviour. The group hosts the BioModels database, a repository for annotated Christoph Steinbeck: biological models. Nicholas has been instrumental Cheminformatics and in the development of Systems Biology Markup Language (SBML), which is designed to facilitate the exchange of biological models between Chris’s group studies small different types of software, and in the development of molecule metabolism in ‘minimum information’ standards. biological systems. Their research includes reconstructing metabolic networks from genomic data and structure Julio Saez-Rodriguez: elucidation and identification of metabolites from Systems biomedicine metabolomics experiments. The group is also Julio’s group develops responsible for the Enzyme Portal, which integrates all computational methods and enzyme-related information resources at EMBL-EBI, tools to analyse signalling and MetaboLights, a database for metabolomics data. networks. They also develop mathematical models to better John Overington: understand how signalling is altered in human and disease and to predict effective therapeutic targets. drug discovery Research aims to invesitagate questions such as: what are the origins of the profound differences in signal John’s group develops and transduction between healthy and diseased cells? Can manages ChEMBL, EMBL-EBI’s we use these differences to predict disease progression database of bioactive, drug-like and to reveal targets for drug development? small molecules. The group is building a computational system to analyse functional and binding data for peptides and analysis of ‘chemical probes’. Other projects include analysis of drug attrition, biotherapeutic drug discovery and open source competitive intelligence.

www.ebi.ac.uk/information/brochures 11 Training

Bioinformatics is a rapidly expanding discipline that touches on all areas of biology – pure and applied. We help bioscientists from all disciplines harness the power of bioinformatics.

EMBL International PhD programme Our lively graduate community is part of EMBL’s International PhD Programme. Many EMBL-EBI PhD students join the ; they participate fully in Cambridge graduate life and leave EMBL-EBI with a PhD from the University of Cambridge. www.ebi.ac.uk/training/studentships/ Postdocs User training Most of our postdocs have external funding, but some Our user training programme empowers life scientists fellowships may be offered as specified positions to make the most of Europe’s most widely used public on our jobs page. If you would like to do your databases. postdoctoral training with us, start by contacting the group leader of your choice directly. At EMBL-EBI www.embl.de/training/postdocs We hold training courses in our purpose-built IT The EMBL Interdisciplinary Postdoctoral Pro- training suite to help experimental biologists get to gramme (EIPOD) encourages candidates whose re- grips with their molecular data. These courses are search crosses scientific boundaries. EIPOD projects very hands-on, and offer direct contact with expert bring together scientific fields that are usually sepa- trainers and high-quality training materials. Browse rate or transfer techniques to a novel context. our courses at: www.ebi.ac.uk/training/handson www.embl.de/training/postdocs/eipod/ The EBI-Sanger Postdoctoral Programme (ESPOD) At your place is for researchers who take both an experimental The EMBL-EBI Bioinformatics Roadshow is a mobile and computational approach to their work. ESPOD training programme for Europe’s most widely used postdocs are supported by easy access to scientific biological data resources. Roadshows can be tailored to expertise, well-equipped facilities and an active create bespoke courses suitable for the host institute. To seminar programme. learn how you can host a roadshow, visit our website: www.ebi.ac.uk/training/postdoc/ESPOD www.ebi.ac.uk/training/roadshow Visitors and scholars Online Researchers at all stages of their career may find ways Train online enables you to learn at your own pace to spend time at the EBI. You can find an updated list and at a time that suits you. eLearning modules of opportunities on our website. complement our face-to-face training programmes. www.ebi.ac.uk/training/Visitors_Programme www.ebi.ac.uk/training/online

12 www.ebi.ac.uk/information/brochures Supporting industry

A comprehensive programme for Joint pre-competitive initiatives Europe’s bioindustries Our programme supports pre-competitive projects, which aim to translate research discoveries into The EMBL-EBI Industry Programme enables industry advances in , health and agriculture for the to adapt quickly to – and maximise the benefit from – benefit of society. advances in bioinformatics. We are a key partner in many Innovative Since 1996 we have been fostering pre-competitive Initiative (IMI) projects. IMI (http://imi.europa.eu) is collaboration and providing expert training in a joint initiative to foster pre-competitive collaboration workshops defined by our members, who represent within the pharmaceutical industry and is co- many of the world’s leading pharmaceutical, agri- sponsored by the European Commission and EFPIA food and diagnostics companies. (European Federation of Pharmaceutical Industries and The EMBL-EBI Industry Programme is a leader in Associations). the development of open standards that protect our EMBL-EBI is also a member of the Pistoia Alliance partners from becoming locked into proprietary (www.pistoiaalliance.org), an organisation established solutions. The programme is member-funded, and by life science companies wishing to streamline non- membership is by invitation only. competitive elements of the pharmaceutical drug- discovery process. Industry Programme members

Astellas Pharma Inc. Nestlé Research Centre AstraZeneca Novartis Pharma AG Join us Bayer Pharma AG Novo Nordisk To learn how your company can benefit from our Industry Programme, visit www.ebi.ac.uk/industry Boehringer Ingelheim Orion Pharma Galderma Pfizer Ltd A brochure about the programme is also available: www.ebi.ac.uk/Information/Brochures GlaxoSmithKline Syngenta To discuss joining the programme, please contact Eli Lilly and Company Sanofi-Aventis the Programme Director, Dominic Clark: F. Hoffmann-La Roche UCB [email protected] Johnson & Johnson Unilever Pharmaceutical R&D Merck Serono S.A. Support for SMEs EMBL-EBI reaches out to small and medium-sized enterprises (SMEs) in our annual SME Support Forum, a two-day workshop that is held in a different region of Europe every year and is co-sponsored by participating regional cluster and membership organisations. The workshops help SMEs make the most of freely available molecular data resources, tools and services provided by EMBL-EBI and its collaborators. They also offer an opportunity for us to clarify some important international data-sharing agreements underlying these data resources and to share a roadmap for future developments. To learn more about hosting or participating in an EMBL-EBI SME Support Forum, contact the programme organisers: [email protected] For information about upcoming events, sign up for our SME mailing list: www.ebi.ac.uk/industry/SME

www.ebi.ac.uk/information/brochures 13 The European Research Area

Europe has always been at the forefront of EMBL-EBI is involved in data management in several bioinformatics research, but as we move towards other ESFRI projects. We lead the BioMedBridges the ’s goal of a single European project, which will ensure transparent data access Research Area, there is a greater need than ever for between all of Europe’s Biological and Medical bioinformatics experts and experimental biologists Sciences Research Infrastructures. throughout Europe to work together towards common goals that will expedite biological research. Other pan-European projects To this aim, EMBL-EBI coordinates the preparatory The Drug Disease Model Resources consortium phase of the ELIXR project and several other EU- (www.ddmore.eu) is developing a common definition funded projects. language for data, models and workflows to create better computational models of disease. The project ELIXIR is also developing an ontology-based standard for storage and transfer of models and associated Research and innovation in the life sciences is helping metadata, and a publicly available drug and disease us tackle some of the serious challenges facing society, model library. including healthcare for an ageing population, security of food supply, protection of the environment EHR4CR (www.ehr4cr.eu) aims to design and and economic competitiveness. demonstrate a scalable and cost-effective approach to interoperability between electronic health record EMBL-EBI coordinates ELIXIR (www.elixir-europe.org), systems and clinical research. a research infrastructure that is defining how Europe will manage and integrate its growing volume and variety of EMTRAIN (www.emtrain.eu) is establishing a biological data. This large-scale initiative will provide sustainable, pan-European platform for education the facilities necessary for life science researchers to and training covering the whole life-cycle of share, analyse and protect our rapidly growing store medicines research, from basic science through of information about living systems. clinical development to pharmacovigilance. ELIXIR brings together Europe’s leading bioscience eTOX (www.etoxproject.eu) is developing a drug facilities to manage biological data in a sustainable safety database from the pharmaceutical industry way. This should enable all facets of the life science legacy toxicology reports and public toxicology data, community – from health to agriculture – to extract and is developing strategies and software tools to optimum value from work that has already been done, predict the toxicological profiles of small molecules and whose we can now only imagine. in early stages of the drug development pipeline.

EU-OPENSCREEN (www.eu-openscreen.de), the European Infrastructure of Open Screening Platforms for Chemical Biology, integrates high-throughput screening platforms, chemical libraries, chemical resources for hit discovery and optimisation, bio- and cheminformatics support, and a database containing screening results, assay protocols, and chemical information.

ELIXIR will complement the capabilities of its participating organisations, including EMBL- EBI. It is a research infrastructure of universal relevance to the life sciences.

14 www.ebi.ac.uk/information/brochures How to find us

EMBL-EBI is situated on the Wellcome Trust EMBL-EBI Genome Campus in the village of Hinxton, which is Wellcome Trust Genome Campus 12 miles south of the city of Cambridge in the UK. Hinxton, Cambridgeshire We are 14 miles from London Stansted airport and CB10 1SD, United Kingdom can be easily reached by car. For more on getting +44 (0)1223 494 444 here, visit www.ebi.ac.uk/Information/Travel

Driving directions From the South: From the North: Leave the M11 at junction 9 and take the A1301 Leave the M11 at junction 10, marked ‘Saffron towards Cambridge. From the Stump Cross Walden’. Travel a mile or so in the direction of roundabout system take the first left (about Saffron Walden to a roundabout and take the 800m). At the next small roundabout follow the third exit (A1301 towards Saffron Walden). signpost for the Genome Campus. Pass two turnings to Hinxton, and take the next right, a small roundabout, with a sign post for Genome Campus.

www.ebi.ac.uk/information/brochures 15 EMBL-EBI

EMBL member states: Austria, Belgium, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom. Associate member state: Australia

EMBL-EBI is part of the European Molecular Biology Laboratory.

16 www.ebi.ac.uk/information/brochures