Database, Vol. 2011, Article ID bar009, doi:10.1093/database/bar009 ............................................................................................................................................................................................................................................................................................. Original article UniProt Knowledgebase: a hub of integrated protein data Michele Magrane1,* and UniProt Consortium1,2,3 1European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, 2Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland, 3Protein Information Resource, Georgetown University Medical Center, 3300 Whitehaven St. NW, Suite 1200, Washington, DC 20007; University of Delaware, 15 Innovation Way, Suite 205, Newark, DE 19711, USA *Corresponding author: Tel: +44 (0)1223 494 656; Fax: +44 (0)1223 494 468; Email:
[email protected] Submitted 24 November 2010; Accepted 10 March 2011 ............................................................................................................................................................................................................................................................................................. The UniProt Knowledgebase (UniProtKB) acts as a central hub of protein knowledge by providing a unified view of protein sequence and functional information. Manual and automatic annotation procedures are used to add data directly to