DOCSLIB.ORG

Functional Defecation Disorders in Children Functional Defecation Disorders in Children Ilanilan Jasper Jasper Nader Nader Koppen Koppen

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

UITNODIGINGUITNODIGING VoorVoor het bijwonen het bijwonen van devan openbare de openbare verdedigingverdediging van hetvan proefschrift het proefschrift FUNCTIONALFUNCTIONAL DEFECATION DEFECATION DISORDERSDISORDERS IN CHILDRENIN CHILDREN novelnovel insights insights into into epidemiology, epidemiology, evaluationevaluation and and management management doordoor FUNCTIONAL DEFECATION DISORDERS IN CHILDREN DISORDERS DEFECATION FUNCTIONAL IN CHILDREN DISORDERS DEFECATION FUNCTIONAL ILANILAN JASPER JASPER NADER NADER KOPPEN KOPPEN VrijdagVrijdag 6 april 6 april 2018 2018 om 12.00om 12.00 uur uur FUNCTIONALFUNCTIONAL DEFECATION DEFECATION in dein Agnietenkapel de Agnietenkapel OudezijdsOudezijds Voorburgwal Voorburgwal 229-231 229-231 DISORDERSDISORDERS IN IN CHILDREN CHILDREN AmsterdamAmsterdam novelnovel insights insights into into epidemiology, epidemiology, Na afloopNa afloop bent bentu van u vanharte harte uitgenodigd uitgenodigd voorvoor de receptie de receptie ter plaatse. ter plaatse. evaluationevaluation and and management management PARANIMFENPARANIMFEN Dan DanDori Dori 06-1033595406-10335954 MischaMischa Hoogeveen Hoogeveen 06-4153085906-41530859 ILAN J.N. KOPPEN ILAN J.N. KOPPEN ILAN J.N. ILANILAN KOPPEN KOPPEN [email protected]@amc.nl 06-1984066006-19840660 ILANILAN J.N. J.N. KOPPEN KOPPEN 14781-koppen-cover.indd14781-koppen-cover.indd 1 1 19/02/201819/02/2018 12:18 12:18 FUNCTIONAL DEFECATION DISORDERS IN CHILDREN novel insights into epidemiology, evaluation and management Ilan J.N. Koppen 14781-koppen-layout.indd 1 19/02/2018 21:53 Part of the research in this thesis was funded by The Royal Netherlands Academy of Arts and Sciences (Academy Ter Meulen Grant) and the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (Charlotte Anderson Travel Award). The printing of this thesis was financially supported by: Universiteit van Amsterdam, Nederlandse Vereniging voor Gastroenterologie, Chipsoft, Coloplast B.V., Hero Benelux, Ipsen Farmaceutica B.V., Mead Johnson B.V., Medical Measurement Systems B.V., Norgine B.V., Nutricia Early Life Nutrition, Solgar Vitamins Holland, Teva Nederland B.V., Wellspect HealthCare, Winclove B.V., Yakult Nederland B.V. Layout & cover design: Design Your Thesis | www.designyourthesis.com Printing: Ridderprint B.V. | www.ridderprint.nl ISBN: 978-94-6299-907-7 Copyright © 2018 by Ilan J.N. Koppen. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications. 14781-koppen-layout.indd 2 19/02/2018 21:53 FUNCTIONAL DEFECATION DISORDERS IN CHILDREN novel insights into epidemiology, evaluation and management ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 6 april 2018, te 12.00 uur door Ilan Jasper Nader Koppen geboren te Amsterdam 14781-koppen-layout.indd 3 19/02/2018 21:53 PROMOTIECOMMISSIE: Promotores: Prof. dr. M.A. Benninga AMC-UvA Prof. dr. C. Di Lorenzo The Ohio State University Overige leden: Dr. D.K. Bosman AMC-UvA Prof. dr. A.J.P.M. Smout AMC-UvA Prof. dr. H.C.P.M. van Weert AMC-UvA Prof. dr. E.H.H.M. Rings Erasmus Universiteit Rotterdam Prof. dr. C.J. Fijnvandraat AMC-UvA Prof. dr. I. de Blaauw Radboud Universiteit Nijmegen Faculteit der Geneeskunde 14781-koppen-layout.indd 4 19/02/2018 21:53 Wonders of the Human Body “How Do It Know?” There’s an intestinal structure that is not very famous But deserves great credit, and that’s the human anus. It practices active, but discrete discrimination In the never-ending process of waste elimination. And due to its location it receives adverse attention In the continuing duty of thoughtful retention. Scientists proclaimed matter’s form in three types of status But already the anus could differentiate: firm, fluid, or flatus But “how do it know” which substance to safely pass When confronted with solid, liquid, or gas? And fortunately “it do know” and doesn’t need to think As it completes each task with a self-satisfied wink! Wallace D. Brown Journal of Pediatric Gastroenterology and Nutrition 1995;20(4):481 Permission for reuse granted by Wolters Kluwer Health, Inc. 14781-koppen-layout.indd 5 19/02/2018 21:53 TABLE OF CONTENTS General introduction and outline of the thesis 9 PART I EPIDEMIOLOGY Chapter 1 Prevalence of functional defecation disorders in children; a 31 systematic review and meta-analysis Chapter 2 Is there an association between functional constipation and 61 excessive bodyweight in children? Chapter 3 Functional defecation disorders and excessive body weight: a 73 systematic review Chapter 4 Attention deficit hyperactivity disorder and functional defecation 97 disorders in children PART II EVALUATION Chapter 5 Using the Bristol Stool Scale and parental report of stool 115 consistency as part of the Rome III criteria for functional constipation in infants and toddlers Chapter 6 The Brussels Infant and Toddler Stool Scale ('BITSS'): a study on 129 inter-rater reliability Chapter 7 Characterizing colonic motility in children with chronic intractable 149 constipation: a look beyond high-amplitude propagating sequences Chapter 8 Impaired postprandial colonic response in the presence of 175 coordinated propagating colonic contractions suggests an extrinsic neuropathy in children and adolescents with intractable functional constipation Chapter 9 Segmental colonic dilation is associated with premature 193 termination of high-amplitude propagating contractions in children with intractable functional constipation 14781-koppen-layout.indd 6 19/02/2018 21:53 PART III MEDICAL MANAGEMENT Chapter 10 Awareness and implementation of the 2014 ESPGHAN/ 213 NASPGHAN guideline for childhood functional constipation Chapter 11 Adherence to polyethylene glycol treatment in children with 227 functional constipation is associated with parental illness perceptions, satisfaction with treatment and perceived treatment convenience Chapter 12 Is there a role for pre-, pro- and synbiotics in the treatment of 247 functional constipation in children? A systematic review Chapter 13 Transanal irrigation in the treatment of children with intractable 265 functional constipation PART IV SURGICAL MANAGEMENT Chapter 14 Surgical decision-making in the management of children with 279 intractable functional constipation: what are we doing and are we doing it right? Chapter 15 Sacral nerve stimulation for constipation and fecal incontinence 299 in children: long-term outcomes, patient benefit, and parent satisfaction Chapter 16 Surgical management of children with intractable functional 315 constipation; experience of a single tertiary children's hospital Summary and discussion 335 Nederlandse samenvatting en discussie 347 Appendices Contributing authors 359 List of publications 363 PhD portfolio 369 Dankwoord 373 About the author 379 14781-koppen-layout.indd 7 19/02/2018 21:53 14781-koppen-layout.indd 8 19/02/2018 21:53 GENERAL INTRODUCTION AND OUTLINE OF THE THESIS Parts of this introduction have been published as: Childhood constipation: finally something is moving! Ilan J.N. Koppen, Carlo Di Lorenzo, Miguel Saps, Phil G. Dinning, Desale Yacob, Marc A. Levitt, Marc A. Benninga Expert Review of Gastroenterology & Hepatology 2016;10:141-55 & Chapter: Functional Constipation in Children Ilan J.N. Koppen, Marc A. Benninga In: Faure C., Thapar N., Di Lorenzo C. (eds) Pediatric Neurogastroenterology pp.445-458 (2017) Springer, New York. 14781-koppen-layout.indd 9 19/02/2018 21:53 14781-koppen-layout.indd 10 19/02/2018 21:53 General introduction and outline of the thesis PHYSIOLOGY OF DEFECATION The dynamics of defecation are complex and rely on intricate processes involving the autonomic and somatic nervous system, pelvic floor muscles, and internal and external anal sphincters. After passing the stomach, duodenum, jejunum and ileum, chyme is transported from the terminal ileum into the caecum. Subsequently, luminal contents are moved distally through the colon while gradual desiccation and mixing occurs, resulting in progressively solid fecal material.1 The propulsion of feces is achieved by complex colonic motor patterns. Several different colonic motor patterns have been described, with the most well recognized being high-amplitude propagating contractions2,3, which are associated with the mass movement of colonic contents and spontaneous defecation in healthy adults.4,5 Anterograde propagation of feces through the colon leads to filling of the rectum, which induces relaxation of the internal anal sphincter, allowing feces to travel further down the anal canal; this reflex is known as the recto-anal inhibitory reflex. Subsequently, sensory stimuli triggered by rectal distension and by the contact between fecal material and the mucosa of the proximal part of the anal canal result in an urge to defecate. At this point, voluntary contraction of the external anal sphincter and pelvic floor muscles can postpone defecation, by moving the fecal load higher up in the rectum, until place and time are appropriate for defection. When defecation is initiated, voluntary relaxation of the external anal sphincter and the pelvic floor musculature (i.e. the puborectalis muscle and levator ani) allows
Recommended publications
  • Megaesophagus in Congenital Diaphragmatic Hernia

    Megaesophagus in Congenital Diaphragmatic Hernia

    Megaesophagus in congenital diaphragmatic hernia M. Prakash, Z. Ninan1, V. Avirat1, N. Madhavan1, J. S. Mohammed1 Neonatal Intensive Care Unit, and 1Department of Paediatric Surgery, Royal Hospital, Muscat, Oman For correspondence: Dr. P. Manikoth, Neonatal Intensive Care Unit, Royal Hospital, Muscat, Oman. E-mail: [email protected] ABSTRACT A newborn with megaesophagus associated with a left sided congenital diaphragmatic hernia is reported. This is an under recognized condition associated with herniation of the stomach into the chest and results in chronic morbidity with impairment of growth due to severe gastro esophageal reflux and feed intolerance. The infant was treated successfully by repair of the diaphragmatic hernia and subsequently Case Report Case Report Case Report Case Report Case Report by fundoplication. The megaesophagus associated with diaphragmatic hernia may not require surgical correction in the absence of severe symptoms. Key words: Congenital diaphragmatic hernia, megaesophagus How to cite this article: Prakash M, Ninan Z, Avirat V, Madhavan N, Mohammed JS. Megaesophagus in congenital diaphragmatic hernia. Indian J Surg 2005;67:327-9. Congenital diaphragmatic hernia (CDH) com- neonate immediately intubated and ventilated. His monly occurs through the posterolateral de- vital signs improved dramatically with positive pres- fect of Bochdalek and left sided hernias are sure ventilation and he received antibiotics, sedation, more common than right. The incidence and muscle paralysis and inotropes to stabilize his gener- variety of associated malformations are high- al condition. A plain radiograph of the chest and ab- ly variable and may be related to the side of domen revealed a left sided diaphragmatic hernia herniation. The association of CDH with meg- with the stomach and intestines located in the left aesophagus has been described earlier and hemithorax (Figure 1).
  • Pediatric Gastroesophageal Reflux Clinical Practice

    Pediatric Gastroesophageal Reflux Clinical Practice

    SOCIETY PAPER Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition ÃRachel Rosen, yYvan Vandenplas, zMaartje Singendonk, §Michael Cabana, jjCarlo DiLorenzo, ôFrederic Gottrand, #Sandeep Gupta, ÃÃMiranda Langendam, yyAnnamaria Staiano, zzNikhil Thapar, §§Neelesh Tipnis, and zMerit Tabbers ABSTRACT This document serves as an update of the North American Society for Pediatric INTRODUCTION Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European n 2009, the joint committee of the North American Society for Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Pediatric Gastroenterology, Hepatology, and Nutrition (NASP- 2009 clinical guidelines for the diagnosis and management of gastroesophageal GHAN)I and the European Society for Pediatric Gastroenterology, refluxdisease(GERD)ininfantsandchildrenandisintendedtobeappliedin Hepatology, and Nutrition (ESPGHAN) published a medical posi- daily practice and as a basis for clinical trials. Eight clinical questions addressing tion paper on gastroesophageal reflux (GER) and GER disease diagnostic, therapeutic and prognostic topics were formulated. A systematic (GERD) in infants and children (search until 2008), using the 2001 literature search was performed from October 1, 2008 (if the question was NASPGHAN guidelines as an outline (1). Recommendations were addressed
  • Abdominal Wall Defects—Current Treatments

    Abdominal Wall Defects—Current Treatments

    children Review Abdominal Wall Defects—Current Treatments Isabella N. Bielicki 1, Stig Somme 2, Giovanni Frongia 3, Stefan G. Holland-Cunz 1 and Raphael N. Vuille-dit-Bille 1,* 1 Department of Pediatric Surgery, University Children’s Hospital of Basel (UKBB), 4056 Basel, Switzerland; [email protected] (I.N.B.); [email protected] (S.G.H.-C.) 2 Department of Pediatric Surgery, University Children’s Hospital of Colorado, Aurora, CO 80045, USA; [email protected] 3 Section of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, 69120 Heidelberg, Germany; [email protected] * Correspondence: [email protected]; Tel.: +41-61-704-27-98 Abstract: Gastroschisis and omphalocele reflect the two most common abdominal wall defects in newborns. First postnatal care consists of defect coverage, avoidance of fluid and heat loss, fluid administration and gastric decompression. Definitive treatment is achieved by defect reduction and abdominal wall closure. Different techniques and timings are used depending on type and size of defect, the abdominal domain and comorbidities of the child. The present review aims to provide an overview of current treatments. Keywords: abdominal wall defect; gastroschisis; omphalocele; treatment 1. Gastroschisis Citation: Bielicki, I.N.; Somme, S.; 1.1. Introduction Frongia, G.; Holland-Cunz, S.G.; Gastroschisis is one of the most common congenital abdominal wall defects in new- Vuille-dit-Bille, R.N. Abdominal Wall borns. Children born with gastroschisis have a full-thickness paraumbilical abdominal Defects—Current Treatments. wall defect, which is associated with evisceration of bowel and sometimes other organs Children 2021, 8, 170.
  • Guideline for the Evaluation of Cholestatic Jaundice

    Guideline for the Evaluation of Cholestatic Jaundice

    CLINICAL GUIDELINES Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition ÃRima Fawaz, yUlrich Baumann, zUdeme Ekong, §Bjo¨rn Fischler, jjNedim Hadzic, ôCara L. Mack, #Vale´rie A. McLin, ÃÃJean P. Molleston, yyEzequiel Neimark, zzVicky L. Ng, and §§Saul J. Karpen ABSTRACT Cholestatic jaundice in infancy affects approximately 1 in every 2500 term PREAMBLE infants and is infrequently recognized by primary providers in the setting of holestatic jaundice in infancy is an uncommon but poten- physiologic jaundice. Cholestatic jaundice is always pathologic and indicates tially serious problem that indicates hepatobiliary dysfunc- hepatobiliary dysfunction. Early detection by the primary care physician and tion.C Early detection of cholestatic jaundice by the primary care timely referrals to the pediatric gastroenterologist/hepatologist are important physician and timely, accurate diagnosis by the pediatric gastro- contributors to optimal treatment and prognosis. The most common causes of enterologist are important for successful treatment and an optimal cholestatic jaundice in the first months of life are biliary atresia (25%–40%) prognosis. The Cholestasis Guideline Committee consisted of 11 followed by an expanding list of monogenic disorders (25%), along with many members of 2 professional societies: the North American Society unknown or multifactorial (eg, parenteral nutrition-related) causes, each of for Gastroenterology, Hepatology and Nutrition, and the European which may have time-sensitive and distinct treatment plans. Thus, these Society for Gastroenterology, Hepatology and Nutrition. This guidelines can have an essential role for the evaluation of neonatal cholestasis committee has responded to a need in pediatrics and developed to optimize care.
  • Intestinal Malrotation: a Diagnosis to Consider in Acute Abdomen In

    Intestinal Malrotation: a Diagnosis to Consider in Acute Abdomen In

    Submitted on: 05/20/2018 Approved on: 08/07/2018 CASE REPORT Intestinal malrotation: a diagnosis to consider in acute abdomen in newborns Antônio Augusto de Andrade Cunha Filho1, Paula Aragão Coimbra2, Adriana Cartafina Perez-Bóscollo3, Robson Azevedo Dutra4, Katariny Parreira de Oliveira Alves5 Keywords: Abstract Intestinal obstruction, Intestinal malrotation is an anomaly of the midgut, resulting from an embryonic defect during the phases of herniation, Acute abdomen, rotation, and fixation. The objective is to report a case of complex diagnostics and approach. The diagnosis was made Gastrointestinal tract. surgically in a patient presenting with hemodynamic instability, abdominal distension, signs of intestinal obstruction, and pneumoperitoneum on abdominal X-ray, with suspected grade III necrotizing enterocolitis. During surgery, a volvulus resulting from poor intestinal rotation was found at a distance of 12 cm from the ileocecal valve. Hemodynamic instability and abdominal distension recurred, and another exploratory laparotomy was required to correct new intestinal perforations. Therefore, early diagnosis with surgical correction before a volvulus appears is essential. Abdominal Doppler ultrasonography has been promising for early diagnosis. 1 Academic in Medicine - Federal University of the Triângulo Mineiro - Uberaba - Minas Gerais - Brazil 2 Resident in Pediatric Intensive Care - Federal University of the Triângulo Mineiro - Uberaba - Minas Gerais - Brazil 3 Associate Professor - Federal University of the Triângulo Mineiro - Uberaba - Minas Gerais - Brazil. 4 Adjunct Professor - Federal University of the Triângulo Mineiro - Uberaba - Minas Gerais - Brazil 5 Academic in Medicine - Federal University of the Triângulo Mineiro - Uberaba - Minas Gerais - Brazil Correspondence to: Antônio Augusto de Andrade Cunha Filho. Universidade Federal do Triângulo Mineiro, Acadêmico de Medicina - Uberaba - Minas Gerais - Brasil.
  • Faecal Retention: a Common Cause in Functional Bowel Disorders, Appendicitis and Haemorrhoids

    Faecal Retention: a Common Cause in Functional Bowel Disorders, Appendicitis and Haemorrhoids

    PHD THESIS DANISH MEDICAL JOURNAL Faecal retention: A common cause in functional bowel disorders, appendicitis and haemorrhoids – with medical and surgical therapy Dennis Raahave quality of life and work (12,13). Currently, IBS is subdivided into This review has been accepted as a thesis together with seven original papers by University of Copenhagen 13th of june 2014 and defended on 6th of october 2014. IBS-C (constipation dominant), IBS-D (diarrhoea dominant), IBS-M Tutor: Randi Beier-Holgersen (mixed) and IBS-A (alternating), but does not have a clear aetiology. Official opponents: Steven D Wexner, Niels Qvist and Jacob Rosenberg. Constipation has many causes, including metabolic, endocrine, Correspondence: Department of Surgery, Colorectal Laboratory, Copenhagen University neurogenic, pharmacologic, mechanical, psychological, and idiopa - Nordsjællands Hospital, Dyrehavevej 29, 3400, Hilleroed, Denmark. thic, but only a few studies have focussed on the length of the colon E-mail: [email protected] as a cause of constipation (14,15,16, 17). Both constipation and IBS sufferers constantly seek care because of persisting symptoms in Dan Med J 2015;62(3):B5031 spite of many investigative procedures and therapeutic efforts, incurring high health care costs (12). When physically examining such a patient, two observations are ARTICLES INCLUDED IN THE THESIS: evident. Frequently a soft mass in the right iliac fossa is palpated 1. Raahave D, Loud FB. Additional faecal reservoirs or hidden constipation: a link between functional and organic bowel disease. Dan Med Bull 2004;51:422-5. with tenderness (suspicious of a faecal reservoir in the right colon) 2. Raahave D, Christensen E, Loud FB, Knudsen LL.
  • Statistical Analysis Plan

    Statistical Analysis Plan

    Cover Page for Statistical Analysis Plan Sponsor name: Novo Nordisk A/S NCT number NCT03061214 Sponsor trial ID: NN9535-4114 Official title of study: SUSTAINTM CHINA - Efficacy and safety of semaglutide once-weekly versus sitagliptin once-daily as add-on to metformin in subjects with type 2 diabetes Document date: 22 August 2019 Semaglutide s.c (Ozempic®) Date: 22 August 2019 Novo Nordisk Trial ID: NN9535-4114 Version: 1.0 CONFIDENTIAL Clinical Trial Report Status: Final Appendix 16.1.9 16.1.9 Documentation of statistical methods List of contents Statistical analysis plan...................................................................................................................... /LQN Statistical documentation................................................................................................................... /LQN Redacted VWDWLVWLFDODQDO\VLVSODQ Includes redaction of personal identifiable information only. Statistical Analysis Plan Date: 28 May 2019 Novo Nordisk Trial ID: NN9535-4114 Version: 1.0 CONFIDENTIAL UTN:U1111-1149-0432 Status: Final EudraCT No.:NA Page: 1 of 30 Statistical Analysis Plan Trial ID: NN9535-4114 Efficacy and safety of semaglutide once-weekly versus sitagliptin once-daily as add-on to metformin in subjects with type 2 diabetes Author Biostatistics Semaglutide s.c. This confidential document is the property of Novo Nordisk. No unpublished information contained herein may be disclosed without prior written approval from Novo Nordisk. Access to this document must be restricted to relevant parties.This
  • Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2017

    Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2017

    Appendix 3.1 Birth Defects Descriptions for NBDPN Core, Recommended, and Extended Conditions Updated March 2017 Participating members of the Birth Defects Definitions Group: Lorenzo Botto (UT) John Carey (UT) Cynthia Cassell (CDC) Tiffany Colarusso (CDC) Janet Cragan (CDC) Marcia Feldkamp (UT) Jamie Frias (CDC) Angela Lin (MA) Cara Mai (CDC) Richard Olney (CDC) Carol Stanton (CO) Csaba Siffel (GA) Table of Contents LIST OF BIRTH DEFECTS ................................................................................................................................................. I DETAILED DESCRIPTIONS OF BIRTH DEFECTS ...................................................................................................... 1 FORMAT FOR BIRTH DEFECT DESCRIPTIONS ................................................................................................................................. 1 CENTRAL NERVOUS SYSTEM ....................................................................................................................................... 2 ANENCEPHALY ........................................................................................................................................................................ 2 ENCEPHALOCELE ..................................................................................................................................................................... 3 HOLOPROSENCEPHALY.............................................................................................................................................................
  • Duplication Cyst with Intestinal Volvulus Causing Intestinal Atresia/Stenosis in Neonates

    Duplication Cyst with Intestinal Volvulus Causing Intestinal Atresia/Stenosis in Neonates

    Journal of Neonatal Surgery 2018; 7:43 DOI: 10.21699/jns.v7i4.820. CASE SERIES Duplication Cyst with Intestinal Volvulus Causing Intestinal Atresia/Stenosis in Neonates Muhammad Bilal Mirza*, Imran Hashim, Shabbir Ahmad, Nabila Talat, M Zubair Shaukat, Muhammad Saleem Department of Pediatric Surgery, The Children’s Hospital and The Institute of Child Health, Lahore, Pakistan How to cite: Mirza B, Hashim I, Ahmad S, Talat N, Shaukat MZ, Saleem M. Duplication cyst with intestinal volvulus causing intestinal atresia/ stenosis in neonates. J Neonatal Surg. 2018; 7:43. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Duplication cysts of small bowel seldom present in newborns and usually represent the development of complications. In utero complications may lead to mesenteric vascular accidents and thus resulting in intestinal atresias. We report three neonates with duplication cyst of small bowel causing localized intestinal volvulus, leading to small bowel intestinal atresia/stenosis. The neonates underwent excision of the duplication cyst and resection anastomosis of the small bowel. Post-operative recovery was uneventful in all three of them. Key words: Atresia; Duplication cyst; Stenosis; Volvulus INTRODUCTION sound of abdomen showed dilated bowel loops. After adequate resuscitation, the patient was operated with Volvulus due to duplication cyst is a rare cause of suspicion of intestinal atresia. At surgery, a 3 cm × neonatal intestinal obstruction [1]. In utero volvulus 5 cm sized non-communicating cyst was encountered due to duplication cyst may also produce intestinal with 3–4 twists causing localized volvulus.
  • Congenital Pyloric Atresia: Clinical Features, Diagnosis, Associated Anomalies, Management and Outcome Osama A

    Congenital Pyloric Atresia: Clinical Features, Diagnosis, Associated Anomalies, Management and Outcome Osama A

    188 Original article Congenital pyloric atresia: clinical features, diagnosis, associated anomalies, management and outcome Osama A. Bawazira,b and Ahmed H. Al-Salemc Background Congenital pyloric atresia (CPA) is very rare period; however, 10 died later giving an overall survival of and usually seen as an isolated anomaly, which has an 40%. Sepsis was the main cause of death. excellent prognosis. CPA can be associated with other Conclusion CPA is a very rare malformation that can be anomalies or familial and these are usually associated with familial and inherited as an autosomal recessive. It can other hereditary conditions with poor prognosis. This either occur as an isolated lesion with an excellent review is based on our experience with 20 infants with CPA. prognosis, or be associated with other anomalies. Patients and methods This is a review of CPA, The overall prognosis of CPA, however, is still poor, and this highlighting its clinical features; associated anomalies; and is due to the frequent-and often fatal-associated aspects of diagnosis, management and outcome. anomalies. Ann Pediatr Surg 13:188–193 c 2017 Annals of Pediatric Surgery. Results This review is based on our experience with 20 patients with CPA (nine male and 11 female). Their mean Annals of Pediatric Surgery 2017, 13:188–193 birth weight was 2.1 kg (1.1-3.9 kg). Polyhydramnios was Keywords: aplasia cutis congenita, congenital pyloric atresia, seen in 13 (65%) patients. Seven patients were full-term epidermolysis bullosa, hereditary multiple intestinal atresia and the remaining 13 were premature. Two were brothers aDepartment of Surgery, Faculty of Medicine, Umm Al Qura University, Makkah, and four were members of the same family.
  • Nova Scotia Atlee Perinatal Database Coding Manual 15 Edition (Version

    Nova Scotia Atlee Perinatal Database Coding Manual 15 Edition (Version

    Nova Scotia Atlee Perinatal Database Coding Manual 15th Edition (Version 15.0.0) April 2011 TABLE OF CONTENTS LISTINGS OF HOSPITALS 11 ADMISSION INFORMATION 16 DELIVERED ADMISSION 26 Routine Information – Delivered Admission 26 Routine Information – Labour 57 Routine Information – Infant 77 UNDELIVERED ADMISSION 94 Routine information – undelivered 94 POSTPARTUM ADMISSIONS 104 Routine Information – Postpartum Admission 104 NEONATAL ADMISSIONS 112 Routine Information – Neonatal Admissions 112 ADULT RCP CODES 124 INFANT RCP CODES 143 INDEX OF MATERNAL DISEASES AND PROCEDURES 179 INDEX OF NEONATAL DISEASES AND PROCEDURES 195 1 INDEX FOR ADMISSION INFORMATION Admission date .............................................................................................................................. 17 Admission time .............................................................................................................................. 17 Admission process status ............................................................................................................... 25 Admission type .............................................................................................................................. 17 A/S/D number ................................................................................................................................ 18 Birth date ....................................................................................................................................... 18 Care provider attending ................................................................................................................
  • The Gastrointestinal Tract Frank A

    The Gastrointestinal Tract Frank A

    91731_ch13 12/8/06 8:55 PM Page 549 13 The Gastrointestinal Tract Frank A. Mitros Emanuel Rubin THE ESOPHAGUS Bezoars Anatomy THE SMALL INTESTINE Congenital Disorders Anatomy Tracheoesophageal Fistula Congenital Disorders Rings and Webs Atresia and Stenosis Esophageal Diverticula Duplications (Enteric Cysts) Motor Disorders Meckel Diverticulum Achalasia Malrotation Scleroderma Meconium Ileus Hiatal Hernia Infections of the Small Intestine Esophagitis Bacterial Diarrhea Reflux Esophagitis Viral Gastroenteritis Barrett Esophagus Intestinal Tuberculosis Eosinophilic Esophagitis Intestinal Fungi Infective Esophagitis Parasites Chemical Esophagitis Vascular Diseases of the Small Intestine Esophagitis of Systemic Illness Acute Intestinal Ischemia Iatrogenic Cancer of Esophagitis Chronic Intestinal Ischemia Esophageal Varices Malabsorption Lacerations and Perforations Luminal-Phase Malabsorption Neoplasms of the Esophagus Intestinal-Phase Malabsorption Benign tumors Laboratory Evaluation Carcinoma Lactase Deficiency Adenocarcinoma Celiac Disease THE STOMACH Whipple Disease Anatomy AbetalipoproteinemiaHypogammaglobulinemia Congenital Disorders Congenital Lymphangiectasia Pyloric Stenosis Tropical Sprue Diaphragmatic Hernia Radiation Enteritis Rare Abnormalities Mechanical Obstruction Gastritis Neoplasms Acute Hemorrhagic Gastritis Benign Tumors Chronic Gastritis Malignant Tumors MénétrierDisease Pneumatosis Cystoides Intestinalis Peptic Ulcer Disease THE LARGE INTESTINE Benign Neoplasms Anatomy Stromal Tumors Congenital Disorders Epithelial Polyps