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2021 – DIGITAL NUKMED21.NUKLEARMEDIZIN.DE 2021ABSTRACTS – DIGITAL 14.17. APRIL 2021 59. JAHRESTAGUNG DER 2021 – DIGITAL DEUTSCHEN GESELLSCHAFT FÜR NUKLEARMEDIZIN Abstracts | NuklearMedizin 2021 – digital Thieme 129 Leuchtturm 165 Präklinische Bildgebung V88–V96 129 Junge Talente L1–L8 168 WIS-Poster 131 Bildgebung und Therapie L9–L16 168 Dosimetrie und Strahlenbiologie P1–P3 134 Technologie, Algorithmen und Radiochemie L17–L24 169 Medizinische Physik P4–P17 137 WIS-Vortrag 174 Onkologie - Bildgebung P18–P30 137 Schilddrüse und Endokrinologie V1–V9 178 Präklinische Bildgebung P31–P37 140 Onkologie - Theranostics V10–V19 180 Radiomics P38–P45 143 Radiochemie und -pharmazie V20–V28 183 Onkologie - Theranostics P46–P59 146 Neurologie V29–V38 187 Varia P60–P65 149 Medizinische Physik V39–V48 189 MTRA-Vortrag 152 Onkologie - Bildgebung V49–V58 189 MTRA-Sitzung 2 TV1–TV3 156 Herz und Entzündung V59–V68 159 Radiomics V69–V78 191 Namenverzeichnis / Authors’ Index 162 Dosimetrie und Strahlenbiologie V79–V87 126 Nuklearmedizin 2021; 60: 126–195 | © 2021. Thieme. All rights reserved. Nuklearmedizin 2021; 60: 126 Abstracts | NuklearMedizin 2021 Mittwoch, 14. April 2021 Stream 1 Stream 2 Stream 3 – 195 | © 2021. Thieme. All rights reserved. Vorkongress- Symposium 13.00 – 18.30 "BRENNPUNKT Nuklearmedizin – 13.00 – 18.30 kontrovers, konstruktiv und kreativ“ Donnerstag, 15. April 2021 – Stream 1 Stream 2 Stream 3 digital Industriesymposium: 08.00 – 09.00 08.00 – 09.00 MIM Software Vortrag 1: MTRA 1: CME-Fortbildung 1: 09.00 – 10.30 Schilddrüse und Endokrinologie CT / MRT Verlaufsuntersuchungen bei COVID-19 09.00 – 10.30 Moderne Nuklearkardiologie (V1 – V9) Erkrankung 10.30 – 10.45 10.30 – 10.45 MTRA 2: CME-Fortbildung 2: Leuchtturm 1: MTRA Vorträge 10.45 – 12.15 Therapie State-of-the-art Updates: "Junge Talente" 10.45 – 12.15 (TV1 – TV3) Tumorerkrankungen (L1 – L8) + Tc-PSMA von der Radiochemie bis zum Befund Industriesymposium: 12.15 – 13.15 12.15 – 13.15 Takeda Pharma Vertrieb GmbH & Co. KG 13.15 – 13.45 13.15 – 13.45 Vortrag 2: CME-Fortbildung 3: MTRA 3: 13.45 – 15.15 Onkologie – Theranostics 13.45 – 15.15 Radiochemie Künstliche Intelligenz in der Medizin (V10 – V19) Industriesymposium: 15.15 – 16.15 15.15 – 16.15 Advanced Accelerator Applications Germany GmbH 16.15 – 16.30 16.15 – 16.30 Leuchtturm 2: Vortrag 3: Sonderveranstaltung: 16.30 – 18.00 Bildgebung und Therapie Radiochemie und –pharmazie 16.30 – 18.00 "Auxiliäre CT in der Hybridbildgebung" (L9 – L16) (V20 – V28) Industriesymposium: Industriesymposium: 18.00 – 19.00 18.00 – 19.00 Sirtex Medical Europe GmbH Terumo Deutschland GmbH Thieme 127 128 Abstracts Freitag, 16. April 2021 | NuklearMedizin 2021 Stream 1 Stream 2 Stream 3 Vortrag 4: Vortrag 5: CME-Fortbildung 4: 08.00 – 09.30 Neurologie Medizinische Physik 08.00 – 09.30 SLN-Diagnostik 2021 – quo vadis? (V29 – V38) (V39 – V48) 09.30 – 09.45 09.30 – 09.45 CME-Fortbildung 5: Leuchtturm 3: Vortrag 6: – – – 09.45 11.15 Organbezogene State-of-the-art Updates: Technologie, Algorithmen und Radiochemie Onkologie Bildgebung 09.45 11.15 – Niere, Update von Pitfalls (L17 – L24) (V49 – V58) digital 11.15 – 11.45 11.15 – 11.45 Industriesymposium: 11.45 – 12.45 11.45 – 12.45 GE Healthcare Buchler GmbH MTRA 4: PSMA-Liganden-Therapie, CME-Fortbildung 6: Vortrag 7: Vorbereitung bis zur Nachsorge 12.45 – 14.15 Organbezogene State-of-the-art Updates: FDG PET/ Herz und Entzündung 12.45 – 14.15 + CT in der Onkologie (V59 – V68) DOTATOC-Liganden-Therapie, Vorbereitung bis zur Nachsorge 14.15 – 14.30 14.15 – 14.30 Industriesymposium: Industriesymposium: Industriesymposium: 14.30 – 15.30 14.30 – 15.30 Siemens Healthineers Pfizer Pharma GmbH Advanced Accelerator Applications Germany GmbH MTRA 5: Vortrag 8: Sonderveranstaltung: Das Elektrokardiogramm in der Nuklearmedizin 15.30 – 17.00 Radiomics 15.30 – 17.00 "Medizinphysik Curriculum" + Nuklearmedizin 2021; 60: 126 (V69 – V78) Belastungsmöglichkeiten der Myokardszintigraphie 17.00 – 17.15 17.00 – 17.15 Vortrag 9: Vortrag 10: CME-Fortbildung 7: 17.15 – 18.45 Dosimetrie und Strahlenbiologie Präklinische Bildgebung 17.15 – 18.45 Berufspolitk (V79 – V87) (V88 – V96) Samstag, 17. April 2021 – 195 | © 2021. Thieme. All rights reserved. Stream 1 Stream 2 Stream 3 Post-Congress-Symposium 09.00 – 13.15 "Stars Of Molecular Imaging And Therapy" 09.00 – 13.15 inkl. Wolfgang Becker-Gedächtnisvorlesung Thieme Abstracts | NuklearMedizin 2021 – digital Thieme N-Me- bzw. Et-[F-18]AFIA wurden mit verschiedenen Modellaminen H2N-R(R= Leuchtturm nBu, tBu, Bn, Ahx-OMe, Phe-OMe, β-Ala-Phe-OMe) zu den entsprechenden Ami- den umgesetzt. F-18-Prg- AFIA wurde über die Cu-vermittelten Click-Reaktion mit Junge Talente BnN3 sowie mit zwei weiteren N3-substituierten PSMA-Liganden konjugiert. Durch die Reaktion von F-18-Me-AFIA mit Lys-OtBu-CO-Glu(OtBu)2(60 °C, 15 min) und L1 Multimodality molecular imaging reveals anschließender Entschützung (12 M HCl, 60 °C, 15 min) wurde ein neuer PSMA- Ligand (F-18-JK-PSMA-15) erhalten, der mittels HPLC isoliert wurde. Die PSMA-Affi- importance of macrophages for adequate cardiac nität und in vivo Stabilität des F-18-JK-PSMA-15 wurde in gesunden Ratten mittels repair in two mouse models of myocardial infarction µPET untersucht. Authors Hess A1, Langer LB1, Ross TL1, Bengel FM1, Thackeray JT1 Ergebnisse/Results F-18-AFIAs wurden innerhalb von 15 min in n.d.c. RCAs Institute 1 Medizinische Hochschule Hannover, Klinik für Nuklearmedizin, von 60±5% produziert. Die Reaktion von F-18-AFIAs mit Modell-Aminen lie- Hannover ferte radiomarkierten Amide in RCUs von 15–98% in 10–20 min bei 40–110 °C. DOI 10.1055/s-0041-1726693 Click-Reaktionen von F-18-Prg-AFIA mit Aziden ergaben die entsprechenden Ziel/Aim Macrophages are involved in cardiac repair following acute myocar- 1,2,3-Triazole in RCUs von 20–30% (15 min, 20–60 °C). F-18-JK-PSMA-15 dial infarction (MI). We investigated effects of macrophage depletion on early wurde in 90 min mit einer RCA von 16% (n.d.c.) und einer radiochemischen inflammation and later functional outcome in two models of MI. Reinheit von >97% sowie einer MA von 100 GBq/µmol hergestellt. Die µPET Methodik/Methods C57BL6 mice received clodronate-liposomes for macro- Evaluation zeigte keine in vivo Defluorierung und eine hohe PSMA-spezifische phage depletion (n=49) or control PBS-liposomes (n=23) 24h prior to perma- Anreicherung des PET-Tracers in den spinalen Ganglien. nent (PO) or transient (I/R, 60min) coronary artery ligation or sham surgery. Schlussfolgerungen/Conclusions F-18-AFIAs sind neue, leicht zugängliche Inflammation was assessed on MI+1, 3, and 7d by CXCR4-targeted PET/CT Markierungsbausteine, die eine effiziente Herstellung radiomarkierter Konju- using Ga-68-pentixafor. Tc-99m-sestamibi SPECT/CT and cardiac magnetic gate mit hoher metabolischer Stabilität unter milden Bedingungen ermöglicht. resonance (CMR) calculated infarct sizes and left ventricular (LV) function at 1 68 and 6wk. F-18-NaF PET/CT measured tissue microcalcification. Imaging signals L3 Ga-FAPI-04 PET/CT for molecular assessment of were validated by ex vivo autoradiography and immunohistochemistry. fibroblast activation and risk evaluation in systemic Ergebnisse/Results Macrophage depletion did not influence infarct size vs sclerosis-related interstitial lung disease PBS, but PO generated significantly larger infarcts compared to I/R (%LV, 32 ± Authors Schmidkonz C1, Distler J2, Treutlein C3, Atzinger A1, Prante O1, 11 vs 14±10, p=0.01). In both models, infarct CXCR4 expression was higher Ritt P1, Götz TI1, Bäuerle T3, Cordes M1, Köhner M1, Kuwert T1, after macrophage depletion vs PBS (%injected dose (ID)/g; d3: PO: 1.4±0.2 vs Ramming A2, Schett G2, Bergmann C2 0.9±0.1; I/R: 1.4±0.2 vs 1.0±0.02; p<0.05), confirmed by autoradiography. Institute 1 Universitätsklinikum Erlangen, Nuklearmedizin, Immunostaining demonstrated fewer macrophages and higher neutrophil con- Erlangen; 2 Universitätsklinikum Erlangen, Rheumatologie, tent. Acute LV rupture after PO was more frequent in clodronate than PBS mice Erlangen; 3 Universitätsklinikum Erlangen, Radiologie, Erlangen (37% vs 17%). At 6wk, surviving PO mice showed a similarly impaired ejection DOI 10.1055/s-0041-1726695 fraction (EF) after macrophage depletion (%, 32±9 vs 32±11, p=0.84). No Ziel/Aim Interstitial lung disease (ILD) is the most common cause of death in acute LV rupture was observed after I/R, but macrophage depletion led to systemic sclerosis (SSc). To date, the progression of SSc-ILD is judged by the worse EF (%, 42 ±11 vs 54±3, p=0.1). Macrophage-depleted mice exhibited a accrual of lung damage on computed tomography (CT) and lung function tes- dense intracavity thrombus adherent to the infarct wall in CMR after PO or I/R. ting. However, diagnostic tools to assess current activity are lacking. Here, we NaF PET identified active calcification at the thrombus at 4wk after PO or I/R, tested the hypothesis that quantification of fibroblast activation by FAPI PET/ colocalized to CT opaque regions at 6wk. CT may correlate with ILD activity and disease progression in SSc-ILD. Schlussfolgerungen/Conclusions Macrophage depletion impairs cardiac Methodik/Methods 21 patients with SSc-ILD confirmed by HRCT and 21 con- repair, including persistent neutrophil recruitment, thrombus formation and trols without ILD were consecutively enrolled. All participants underwent FAPI tissue calcification. This underscores the necessity of macrophages for effective PET/CT imaging and standard-of-care procedures including HRCT and lung healing and may explain adverse response to broad anti-inflammatory therapy function testing (PFT) at baseline. Patients with SSc-ILD patients were follo- in myocardial ischemia. wed-up for 6 months with HRCT and PFT. We compared baseline FAPI PET/CT L2 3-Aza-6—F-18-fluor-isatosäureanhydride (F-18- uptake to standard diagnostic tools and currently used predictors of ILD pro- gression.
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    www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No. 36), pp: 60581-60588 Review Fluorine-18 labeled amino acids for tumor PET/CT imaging Yiqiang Qi1,2,*, Xiaohui Liu1,2,*, Jun Li4, Huiqian Yao5 and Shuanghu Yuan2,3 1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital affiliated to Shandong University, Jinan, Shandong, China 3Shandong Academy of Medical Sciences, Jinan, Shandong, China 4Department of Thoracic Surgery, Shandong Provincial Hospital, Jinan, Shandong, China 5Department of Surgery, Juye Coalfield Central Hospital, Heze, Shandong, China *Authors contributed equally to this work Correspondence to: Shuanghu Yuan, email: [email protected] Keywords: Fluorine-18 labeled amino acids, positron emission tomography/computed tomography (PET/CT), tumor metabolism, molecular imaging Received: May 25, 2017 Accepted: July 25, 2017 Published: August 04, 2017 Copyright: Qi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT Tumor glucose metabolism and amino acid metabolism are usually enhanced, 18F-FDG for tumor glucose metabolism PET imaging has been clinically well known, but tumor amino acid metabolism PET imaging is not clinically familiar. Radiolabeled amino acids (AAs) are an important class of PET/CT tracers that target the upregulated amino acid transporters to show elevated amino acid metabolism in tumor cells. Radiolabeled amino acids were observed to have high uptake in tumor cells but low in normal tissues and inflammatory tissues.
  • Oncologic Applications of Positron Emission Tomography Scanning

    Oncologic Applications of Positron Emission Tomography Scanning

    FEP 6.01.26 Oncologic Applications of Positron Emission Tomography Scanning FEP Medical Policy Manual FEP 6.01.26 Oncologic Applications of Positron Emission Tomography Scanning Related Policies: Effective Policy Date: January 1, 2021 6.01.06 - Miscellaneous (Noncardiac, Nononcologic) Applications of Fluorine 18 Fluorodeoxyglucose Positron Emission Tomography Original Policy Date: June 2012 6.01.20 - Cardiac Applications of Positron Emission Tomography Scanning 6.01.51 - Interim Positron Emission Tomography Scanning in Oncology to Detect Early Response During Treatment Oncologic Applications of Positron Emission Tomography Scanning Description Positron emission tomography (PET) scans are based on the use of positron-emitting radionuclide tracers coupled to organic molecules, such as glucose, ammonia, or water. The radionuclide tracers simultaneously emit 2 high-energy photons in opposite directions that can be simultaneously detected (referred to as coincidence detection) by a PET scanner, comprising multiple stationary detectors that encircle the area of interest. A variety of tracers are used for positron emission tomography (PET) scanning, including oxygen 15, nitrogen 13, carbon 11 choline, fluorine 18, gallium 68, and fluciclovine 18. Because of their short half-life, some tracers must be made locally using an onsite cyclotron. The radiotracer most commonly used in oncology imaging has been fluorine 18 coupled with fluorodeoxyglucose (FDG), which correlates with glucose metabolism. Fluorodeoxyglucose has been considered useful in cancer imaging because tumor cells show increased metabolism of glucose. The most common malignancies studied have been melanoma, lymphoma, lung, colorectal, and pancreatic cancer. This evidence review focuses on the use of radiotracers detected with dedicated PET scanners. Radiotracers, such as FDG, may be detected using single-photon emission computerized tomography cameras, a technique that may be referred to as FDG-single-photon emission computerized tomography imaging.