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Nuclear Medicine in the Context of Personalized Medicine NUCLEAR MEDICINE IN THE CONTEXT OF PERSONALIZED MEDICINE EDITED BY : Françoise Kraeber-Bodéré, Francesco Cicone, Pierre Payoux and Myriam Bernaudin PUBLISHED IN : Frontiers in Medicine Frontiers eBook Copyright Statement About Frontiers The copyright in the text of individual articles in this eBook is the Frontiers is more than just an open-access publisher of scholarly articles: it is a property of their respective authors or their respective institutions or pioneering approach to the world of academia, radically improving the way scholarly funders. The copyright in graphics research is managed. The grand vision of Frontiers is a world where all people have and images within each article may be subject to copyright of other an equal opportunity to seek, share and generate knowledge. Frontiers provides parties. 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Find out more on how ISSN 1664-8714 to host your own Frontiers Research Topic or contribute to one as an author by ISBN 978-2-88963-861-1 DOI 10.3389/978-2-88963-861-1 contacting the Frontiers Editorial Office: [email protected] Frontiers in Medicine 1 July 2020 | Nuclear Medicine in Personalized Medicine NUCLEAR MEDICINE IN THE CONTEXT OF PERSONALIZED MEDICINE Topic Editors: Françoise Kraeber-Bodéré, Centre de Recherche en Cancérologie Nantes Angers, France Francesco Cicone, University of Catanzaro, Italy Pierre Payoux, INSERM U1214 Centre d’Imagerie Neuro Toulouse (ToNIC), France Myriam Bernaudin, Centre National de la Recherche Scientifique (CNRS), France Citation: Kraeber-Bodéré, F., Cicone, F., Payoux, P., Bernaudin, M., eds. (2020). Nuclear Medicine in the Context of Personalized Medicine. Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88963-861-1 Frontiers in Medicine 2 July 2020 | Nuclear Medicine in Personalized Medicine Table of Contents 05 Editorial: Nuclear Medicine in the Context of Personalized Medicine Jacques Barbet, Myriam Bernaudin, Pierre Payoux, Francesco Cicone, Marie-Hélène Gaugler and Françoise Kraeber-Bodéré 07 Interest of FDG-PET in the Management of Mantle Cell Lymphoma Clément Bailly, Thomas Carlier, Cyrille Touzeau, Nicolas Arlicot, Françoise Kraeber-Bodéré, Steven Le Gouill and Caroline Bodet-Milin 11 Interest of Pet Imaging in Multiple Myeloma Bastien Jamet, Clément Bailly, Thomas Carlier, Cyrille Touzeau, Cristina Nanni, Elena Zamagni, Louisa Barré, Anne-Victoire Michaud, Michel Chérel, Philippe Moreau, Caroline Bodet-Milin and Françoise Kraeber-Bodéré 20 [18F]-Fludarabine for Hematological Malignancies Louisa Barré, Narinée Hovhannisyan, Caroline Bodet-Milin, Françoise Kraeber-Bodéré and Gandhi Damaj 25 The Story of the Dopamine Transporter PET Tracer LBT-999: From Conception to Clinical Use Sylvie Chalon, Johnny Vercouillie, Pierre Payoux, Jean-Bernard Deloye, Cécile Malherbe, Florence Le Jeune, Nicolas Arlicot, Anne-Sophie Salabert, Denis Guilloteau, Patrick Emond and Maria-Joao Ribeiro 30 Clinical Results in Medullary Thyroid Carcinoma Suggest High Potential of Pretargeted Immuno-PET for Tumor Imaging and Theranostic Approaches Caroline Bodet-Milin, Clément Bailly, Yann Touchefeu, Eric Frampas, Mickael Bourgeois, Aurore Rauscher, Franck Lacoeuille, Delphine Drui, Nicolas Arlicot, David M. Goldenberg, Alain Faivre-Chauvet, Jacques Barbet, Caroline Rousseau and Françoise Kraeber-Bodéré 37 Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma Michael Gérard, Aurélien Corroyer-Dulmont, Paul Lesueur, Solène Collet, Michel Chérel, Mickael Bourgeois, Dinu Stefan, Elaine Johanna Limkin, Cécile Perrio, Jean-Sébastien Guillamo, Bernard Dubray, Myriam Bernaudin, Juliette Thariat and Samuel Valable 48 Rhenium-188 Labeled Radiopharmaceuticals: Current Clinical Applications in Oncology and Promising Perspectives Nicolas Lepareur, Franck Lacœuille, Christelle Bouvry, François Hindré, Emmanuel Garcion, Michel Chérel, Nicolas Noiret, Etienne Garin and F. F. Russ Knapp Jr. 67 Risk Management Through an “Activity Contradictions” Lens: Exposure to Low Doses of Radiation in Nuclear Medicine Romain Lonceint, Françoise Bodéré and Bénédicte Geffroy Frontiers in Medicine 3 July 2020 | Nuclear Medicine in Personalized Medicine 78 Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience Marie Beaurain, Anne-Sophie Salabert, Maria Joao Ribeiro, Nicolas Arlicot, Philippe Damier, Florence Le Jeune, Jean-François Demonet and Pierre Payoux 110 Cell Tracking in Cancer Immunotherapy Justine Perrin, Marisa Capitao, Marie Mougin-Degraef, François Guérard, Alain Faivre-Chauvet, Latifa Rbah-Vidal, Joëlle Gaschet, Yannick Guilloux, Françoise Kraeber-Bodéré, Michel Chérel and Jacques Barbet Frontiers in Medicine 4 July 2020 | Nuclear Medicine in Personalized Medicine EDITORIAL published: 09 June 2020 doi: 10.3389/fmed.2020.00252 Editorial: Nuclear Medicine in the Context of Personalized Medicine Jacques Barbet 1, Myriam Bernaudin 2, Pierre Payoux 3,4, Francesco Cicone 5,6, Marie-Hélène Gaugler 7 and Françoise Kraeber-Bodéré 8* 1 GIP Arronax, Saint-Herblain, France, 2 Université de Normandie, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP CYCERON, Caen, France, 3 Service de Médecine Nucléaire, CHU de Toulouse, Toulouse, France, 4 ToNIC, Toulouse NeuroImaging Center, UMR1214 Inserm, Toulouse, France, 5 Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Catanzaro, Italy, 6 Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland, 7 Université de Nantes, CNRS, Inserm, CRCINA, Nantes, France, 8 Université de Nantes, CHU de Nantes, ICO Gauducheau, CNRS, Inserm, CRCINA, Nantes, France Keywords: PET, theranostics, radionuclide therapy, solid tumors, hematological malignancies Editorial on the Research Topic Nuclear Medicine in the Context of Personalized Medicine Nuclear Medicine has been at the heart of theranostics even before the term was coined. It provides effective tools for precision medicine particularly with positron emission tomography (PET), and radioligand therapy. It allows the investigation of phenotypes and functions in all areas of medicine and provides innovative tools to kill cancer cells. This Research Topic for Frontiers in Medicine focuses on the role of Nuclear
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