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Generated by SRI International Pathway Tools Version 25.0, Authors S Authors: Pallavi Subhraveti Ingrid Keseler Quang Ong Ron Caspi An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Tim Holland Peter D Karp Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Saur904776Cyc: Staphylococcus aureus aureus IS-24 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari guaninehypoxanthine indole- pro 3-acetate (S)-lactate (S)-lactate uracil H + H + H + H + H + H + H + H + H + ammonium IS24_0964 IS24_2784 AtpC AtpF AtpI AtpA AtpD AtpE AtpB AtpH AtpG Amt PbuG PutP PyrP IS24_1600 + + + + + + + + + indole- H H H H H H H H H uracil (S)-lactate (S)-lactate ammonium 3-acetate guanine pro hypoxanthine Cofactor, Prosthetic Group, Electron Carrier, and Vitamin Biosynthesis Chemoautotrophic Amino Acid Degradation Energy Metabolism Detoxification UDP-N-acetyl- an [apo BCAA an apo-[methylmalonyl- campest- a (3R)-3- 3-(4- valine degradation I a [formate C testosterone a phosphate cob(II)yrinate a,c- glutamine SAM a reduced flavodoxin α-D-muramoyl- di-trans,octa-cis 4-methyl-2- dehydrogenase CoA:pyruvate biotin 5-hydroxytryptophol β hydroxyhexanoyl- hydroxyphenyl) flavin biosynthesis I (bacteria and plants) L-ascorbate biosynthesis V L-ascorbate biosynthesis IV 1,4-dihydroxy-2- glutathione redox reactions I Aromatic Compound Biosynthesis Fermentation heterolactic fermentation hydrogen isoleucine degradation I ornithine degradation II (Stickland reaction) arginine degradation L-serine degradation Protein Degradation acetyltransferase]-glycine 4-en-3 -ol monoester diamide biosynthesis I ubiquinol-8 biosynthesis pantothenate and coenzyme A biosynthesis I biotin biosynthesis superoxide γ 6 naphthoate biosynthesis I VI (arginase degradation II anaerobic L-alanyl- -D- -undecaprenyl oxopentanoate E2 protein] N carboxytransferase]biotin/lipoate A/ alcohol 3-beta 3-beta [acp] beta- putative -3-hydroxy- (prokaryotic) from 8-amino-7- oxidation II radicals branched-chain (early cobalt insertion) β β glutamyl-L-lysyl- phosphate -lipoyl-L-lysine dehydrogenase, hydroxysteroid hydroxysteroid propanoyl-CoA -D-glucose -D-glucose β-D-fructofuranose (aerobic, NAD) val 2 pathway) seed germination wound-induced ribonucleoside- phospho-N- alpha-keto acid B protein ligase hydroxyacyl- alkaline enoyl-CoA all-trans- 3-methyl-2-oxobutanoate oxononanoate I GSSG chorismate biosynthesis I ile L-ornithine ser degradation D-alanyl-D-alanine iron-dependent: dehydrogenase/ dehydrogenase/ arg arg uroporphyrinogen-III GTP 6-phosphate 6-phosphate chorismate 8-amino-7- 2,3-dihydroxybenzoate gln protein turnover proteolysis I triphosphate acetylmuramoyl- family protein: (acyl-carrier- phosphatase hydratase/ 4-hydroxybenzoate octaprenyl H branched-chain- arg dehydrogenase IS24_2133 isomerase isomerase IS24_2879 uroporphyrinogen-III isochorismate biosynthesis 2 branched-chain- glutamate L-serine superoxide reductase undecaprenyl-pentapeptide- IS24_0232 protein) 3: IS24_1051 isomerase diphosphate 3-methyl-2-oxobutanoate oxononanoate manno(fructo) putative soluble subunit E2: C-methyltransferase: α synthase lysine-8-amino-7- D-erythrose 4-phosphate amino-acid amino-acid arginase: synthase dehydratase, superoxide activating transferase: mraY alcohol family protein: family protein: dehydratase family ornithine ornithine GTP -D-glucose α-D-glucose hydroxymethyltransferase: a peptide a peptide diphospho-N- IS24_1207 biotin/lipoate A/ putative 3-octaprenyl-4- family protein: oxononanoate glutathione 3-deoxy-7- chorismate kinase: hydrogenase transaminase: ilvE ornithine [NADPH], large dismutase, protein: nrdG dehydrogenase, IS24_2228 IS24_2704 cobA cyclohydrolase: 6-phosphate 6-phosphate panB transaminase: rocF iron-sulfur- aminopeptidase aminopeptidase acetylmuramoyl- a [apo BCAA dehydrogenase B protein ligase FabZ: fabZ alkaline protein: hydroxybenzoate aminotransferase: peroxidase: phosphoheptulonate IS24_1987 42 kDa subunit: (S)-3-methyl-2-oxopentanoate aminotransferase: UMP [+ 2 isozymes] arg arg precorrin-1 IS24_0644 isochorismate β-D-glucose ilvE L-ornithine subunit: gltA dependent, (Mn): sodA_2 L-alanyl-γ-D- 6 family protein: propanol- 3-beta 3-beta a (2E)-hex- IS24_2055 ribB phosphoglucomutase/ phosphoglucomutase/ glutathione IS24_0365 glutathione IS24_2559 PepS: pepS PepS: pepS pyruvate E2 protein] N -S-[3- phosphatase 2,5-diamino-6- isochorismate bioK synthase: aroF synthase rocD_2 alpha subunit: preferring: adhP 2-enoyl-[acp] 4-coumaryl-CoA IS24_1395 phosphomannomutase, 2-dehydropantoate peroxidase: reductase: 3-deoxy-D-arabino- 3-methyl-2- 3-methyl-2- [+ 2 isozymes] superoxide formate-lyase glutamyl-L-lysyl- methylbutanoyl]dihydrolipoyl- a holo-[methylmalonyl-IS24_1224 hydroxysteroid hydroxysteroid 3: IS24_1052 uroporphyrinogen-III phosphomannomutase, 7,8-diaminopelargonate glutathione family protein: NADH ornithine D-ornithine cytosol cytosol 5-hydroxyindole (5-phospho-D- IS24_1044 lpdA_1 F6P oxobutanoate oxopentanoate ornithine glt sdaAA dismutase, 1-activating D-alanyl-D-alanine L-lysine dehydrogenase/ dehydrogenase/ ornithine ornithine C-methyltransferase: alpha/beta/alpha alpha/beta/alpha 2-dehydropantoate putative 2- peroxidase: heptulosonate-7-phosphate aminopeptidase aminopeptidase CoA:pyruvate acetaldehyde an alcohol ribosylamino) IS24_0644 putative dehydrogenase: aminotransferase: aminotransferase: (Mn): sodA_1 isomerase isomerase cobA domain I: IS24_1752 domain I: IS24_1752 asp 2-reductase: succinyl-5- dethiobiotin 3-methyl-2- L-serine hydrogen family, catalytic family, catalytic enzyme: pflA a [formate C carboxytransferase] pyrimidin- 2-octaprenylphenol superpathway of tetrahydrofolate biosynthesis IS24_1044 3-dehydroquinate isochorismate glucokinase: rocD_1 rocD_2 a flavodoxin family protein: family protein: α-D-glucose α-D-glucose enolpyruvyl- synthase: bioD glucose-6- Hydrogen oxobutanoate lpdA_1 dehydratase, peroxide domain protein: domain protein: met 5'-deoxyadenosine acetyltransferase]- 4(3H)-one IS24_1022 synthase: aroB IS24_1239 semiquinone precorrin-2 aspartate 1- isochorismatase phosphate Production dehydrogenase: ornithine iron-sulfur- IS24_0751 IS24_0751 IS24_2704 IS24_2228 riboflavin 1-phosphate 1-phosphate 2-dehydropantoate 6-hydroxy-3- 2-methylbutanoyl-CoA glycin -2-yl radical androst-4-ene- campest-4- decarboxylase: cyclohexene- dethiobiotin family protein: isomerase: lpdA_1 L-glutamate-5- (2R,4S)-2, 4- aminotransferase: dependent, a peptide a peptide precorrin-2 biosynthesis UTP--glucose- 2-reductase: GTP glutathione 3-dehydroquinate hydrogen 3,17-dione en-3-one UTP--glucose- panD IS24_1408 pgi semialdehyde diaminopentanoate rocD_1 beta subunit: dehydrogenase: protein 3-(all-trans IS24_1706 1- carboxylate S-2-methylbutryl- 1-phosphate 1-phosphate superpathay of heme biotin 3-dehydroquinate production II isobutanoyl-CoA sdaAB IS24_1041 RibD: ribD -octaprenyl) synthase: [+ 2 isozymes] CoA:FAD L-glutamate-5- 2-aminoprop- O uridylyltransferase uridylyltransferase biosynthesis from glutamate β-alanine synthase: bioB dehydratase, (2S,3S)-2,3- 2 a glycopeptide- a (3R,7Z,10Z 5-amino-6-(5- benzene-1,2-diol (R)-pantoate IS24_0641 + isobutyryl- oxidoreductase: semialdehyde 2-enoate poly (glycerol a nucleoside a (3R)-3- 3-hydroxyisovaleryl- family protein: family protein: H 4 4-tyrosol sirohydrochlorin type I: aroD dihydroxy-2,3- IS24_2054 CDP-glycerol D-mannosyl-N a purine ser ,13Z,16Z,19Z)-3- hydroxyicosanoyl- phospho-D- IS24_2733 3-demethylubiquinone- 2-succinyl-5- putative soluble CoA:FAD phosphate) triphosphate CoA GTP IS24_2733 biotin dihydrobenzoate (S)-1-pyrroline- 2-amino-4- arginine degradation V CDP- -(N-acetyl-D- ribonucleoside MazG nucleotide alcohol hydroxydocosa- [acp] enoyl-CoA ribosylamino)uracil glt 9 3-methyltransferase enolpyruvyl-6-hydroxy- hydrogenase oxidoreductase: L-serine dehydratase, beta- sirohydrochlorin UTP--glucose- UTP--glucose- pantoate-- 7,8-dihydroneopterin thiamin diphosphate 3-dehydroshikimate β-D-glucose (E)-2-methylcrotonoyl-CoA 5-carboxylate oxopentanoate (arginine deiminase pathway) glycerol:poly(glycerophosphate) glucosaminyl) purine nucleoside pyrophosphohydrolase dehydrogenase, 7,10,13,16,19- hydratase/ diguanylate riboflavin glutamate-- domain protein: 3-cyclohexene- 42 kDa subunit: IS24_2054 iron-sulfur-dependent, 3-oxoacyl- hydroxyacyl- cobaltochelatase: 1-phosphate 1-phosphate beta-alanine triphosphate thioredoxin biosynthesis I (E.
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