Biography of Roald Hoffmann
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												Fall 2019 SPECIAL DAY/TIME/LOCATION: Friday
The Chemistry and Biochemistry Departmental Seminar Series covers a broad range of fields in the Chemical and Biochemical Sciences. In past seminars, scientists from Academia, Government, and Industry have presented their most recent discoveries and contributions in their respective areas. This Seminar Series offers students and faculty the opportunity to interact directly with other leaders in their specializations and to gain a good overview of the entire range of fields in Chemistry and Biochemistry. Fall 2019 Seminars are held on Tuesdays in CL 1009 (Clendenin Building, Room 1009 on the Kennesaw Campus), 12:30 - 1:30pm, unless otherwise noted with special day/time/location information. All are invited to attend. SPECIAL DAY/TIME/LOCATION: Friday, September 20, 2019 – 2:30pm in CL 2003 Dr. Jeffrey I. Seeman, Department of Chemistry, University of Richmond Title: Was Plagiarism Involved in the Conceptualization of the Woodward-Hoffmann Rules? Abstract: In 1981, Roald Hoffmann and Kenichi Fukui shared the Nobel Prize in Chemistry “for their theories, developed independently, concerning the course of chemical reactions.” Had Robert B. Woodward (1917 – 1979) lived two years longer, he would surely have received his second Nobel Prize in Chemistry for his contributions to the Woodward-Hoffmann rules. In the March 29, 2004 issue of Chemical & Engineering News, E. J. Corey wrote in his Priestley Medal Address, “On May 4, 1964, I suggested to my colleague R. B. Woodward a simple explanation involving the symmetry of the perturbed (HOMO) molecular orbitals for the stereoselective cyclobutene/1,3-butadiene and 1,3,5-hexatriene/cyclohexadiene conversions that provided the basis for the further development of these ideas into what became known as the Woodward-Hoffmann rules.” Letters between Corey and Hoffmann in 1981 and 1984 and other relevant information will be shown and discussed. - 
												
												Nobel Lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y
BUILDING BRIDGES BETWEEN INORGANIC AND ORGANIC CHEMISTRY Nobel lecture, 8 December 1981 by ROALD HOFFMANN Department of Chemistry, Cornell University, Ithaca, N.Y. 14853 R. B. Woodward, a supreme patterner of chaos, was one of my teachers. I dedicate this lecture to him, for it is our collaboration on orbital symmetry conservation, the electronic factors which govern the course of chemical reac- tions, which is recognized by half of the 1981 Nobel Prize in Chemistry. From Woodward I learned much: the significance of the experimental stimulus to theory, the craft of constructing explanations, the importance of aesthetics in science. I will try to show you how these characteristics of chemical theory may be applied to the construction of conceptual bridges between inorganic and organic chemistry. FRAGMENTS Chains, rings, substituents - those are the building blocks of the marvelous edifice of modern organic chemistry. Any hydrocarbon may be constructed on paper from methyl groups, CH 3, methylenes, CH 2, methynes, CH, and carbon atoms, C. By substitution and the introduction of heteroatoms all of the skeletons and functional groupings imaginable, from ethane to tetrodotoxin, may be obtained. The last thirty years have witnessed a remarkable renaissance of inorganic chemistry, and the particular flowering of the field of transition metal organo- metallic chemistry. Scheme 1 shows a selection of some of the simpler creations of the laboratory in this rich and ever-growing field. Structures l-3 illustrate at a glance one remarkable feature of transition metal fragments. Here are three iron tricarbonyl complexes of organic moie- ties - cyclobutadiene, trimethylenemethane, an enol, hydroxybutadiene - which on their own would have little kinetic or thermodynamic stability. - 
												
												Preparation and Characterization of Iridium Hydride and Dihydrogen Complexes Relevant to Biomass Deoxygenation
Preparation and Characterization of Iridium Hydride and Dihydrogen Complexes Relevant to Biomass Deoxygenation Jonathan M. Goldberg A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2017 Reading Committee: D. Michael Heinekey, Chair Karen I. Goldberg, Chair Brandi M. Cossairt Program Authorized to Offer Degree: Department of Chemistry © Copyright 2017 Jonathan M. Goldberg University of Washington Abstract Preparation and Characterization of Iridium Hydride and Dihydrogen Complexes Relevant to Biomass Deoxygenation Jonathan M. Goldberg Chairs of the Supervisory Committee: Professor D. Michael Heinekey Professor Karen I. Goldberg Department of Chemistry This thesis describes the fundamental organometallic reactivity of iridium pincer complexes and their applications to glycerol deoxygenation catalysis. These investigations provide support for each step of a previously proposed glycerol deoxygenation mechanism. Chapter 1 outlines the motivations for this work, specifically the goal of using biomass as a chemical feedstock over more common petroleum-based sources. A discussion of the importance of transforming glycerol to higher value products, such as 1,3-propanediol, is discussed. Chapter 2 describes investigations into the importance of pincer ligand steric factors on the coordination chemistry of the iridium metal center. Full characterization of a five-coordinate iridium-hydride complex is presented; this species was previously proposed to be a catalyst resting state for glycerol deoxygenation. Chapter 3 investigates hydrogen addition to R4(POCOP)Ir(CO) R4 3 t i R4 R4 3 [ POCOP = κ -C6H3-2,6-(OPR2)2 for R = Bu, Pr] and (PCP)Ir(CO) [ (PCP) = κ -C6H3-2,6- t i (CH2PR2)2 for R = Bu, Pr] to give cis- and/or trans-dihydride complexes. - 
												
												Nobel Laureates Endorse Joe Biden
Nobel Laureates endorse Joe Biden 81 American Nobel Laureates in Physics, Chemistry, and Medicine have signed this letter to express their support for former Vice President Joe Biden in the 2020 election for President of the United States. At no time in our nation’s history has there been a greater need for our leaders to appreciate the value of science in formulating public policy. During his long record of public service, Joe Biden has consistently demonstrated his willingness to listen to experts, his understanding of the value of international collaboration in research, and his respect for the contribution that immigrants make to the intellectual life of our country. As American citizens and as scientists, we wholeheartedly endorse Joe Biden for President. Name Category Prize Year Peter Agre Chemistry 2003 Sidney Altman Chemistry 1989 Frances H. Arnold Chemistry 2018 Paul Berg Chemistry 1980 Thomas R. Cech Chemistry 1989 Martin Chalfie Chemistry 2008 Elias James Corey Chemistry 1990 Joachim Frank Chemistry 2017 Walter Gilbert Chemistry 1980 John B. Goodenough Chemistry 2019 Alan Heeger Chemistry 2000 Dudley R. Herschbach Chemistry 1986 Roald Hoffmann Chemistry 1981 Brian K. Kobilka Chemistry 2012 Roger D. Kornberg Chemistry 2006 Robert J. Lefkowitz Chemistry 2012 Roderick MacKinnon Chemistry 2003 Paul L. Modrich Chemistry 2015 William E. Moerner Chemistry 2014 Mario J. Molina Chemistry 1995 Richard R. Schrock Chemistry 2005 K. Barry Sharpless Chemistry 2001 Sir James Fraser Stoddart Chemistry 2016 M. Stanley Whittingham Chemistry 2019 James P. Allison Medicine 2018 Richard Axel Medicine 2004 David Baltimore Medicine 1975 J. Michael Bishop Medicine 1989 Elizabeth H. Blackburn Medicine 2009 Michael S. - 
												
												Carl Djerassi: Chemist and Entrepreneur
Carl Djerassi: Chemist and entrepreneur Eugene Garfield 534 CHEMTECH SEPTEMBER 1983 Much has been said about the scientific entrepreneur. established a precedent for the widely used fragment coding Although the term ordinarily is applied to the person who system employed in the Index Chemicus Registry System has been successful in business—one thinks of Thomas (ICRS) and other systems. Edison or Edwin Land, among others—there also are At the end of the 1940s, much of the excitement centered scientific entrepreneurs in the academic community. It is on the discovery that cortisone could alleviate arthritis not often that one finds a scientist who can fit both symptoms. The chemical was derived from animal bile, but descriptions. To maintain a credible academic existence one initially in amounts too small for treating this chronic, needs enormous dedication and energy; to function in a widespread disease. Scientists around the world were racing scientifically oriented business these qualities as well as to find a more practical method of synthesis. In 1951, significant managerial competence are needed. That rare Djerassi and his team at Syntex won the race; they found a combination of qualities is found in my friend Carl relatively simple way to make cortisone using a readily Djerassi. available raw material, the Mexican yam (2). I recently had the honor of speaking informally at an That same year, Djerassi's team synthesized another unusual event. The numerous friends and collaborators of compound, which received much less attention at the time. Djerassi attended a party celebrating the publication of his They named it "norethisterone," and it was to become the thousandth paper. - 
												
												Melanie S. Sanford
Melanie S. Sanford Department of Chemistry University of Michigan Ann Arbor, MI 48109 Tel. (734) 615-0451 Fax (734) 647-4865 [email protected] Research Group: http://www.umich.edu/~mssgroup/ EDUCATION: Ph.D., Chemistry June 2001 California Institute of Technology, Pasadena, CA Thesis Title: Synthetic and Mechanistic Investigations of Ruthenium Olefin Metathesis Catalysts B.S.; M.S. cum laude with Distinction in Chemistry June 1996 Yale University, New Haven, CT CURRENT POSITION: University of Michigan, Ann Arbor, MI Moses Gomberg Distinguished University Professor of Chemistry September 2016 – present Arthur F. Thurnau Professor of Chemistry July 2011 – present PREVIOUS POSITIONS: University of Michigan, Ann Arbor, MI Moses Gomberg Collegiate Professor of Chemistry January 2012 – Sept 2016 Professor of Chemistry September 2010 – June 2011 Associate Professor of Chemistry May 2007 – August 2010 William R. Roush Assistant Professor of Chemistry October 2006 – May 2007 Assistant Professor of Chemistry July 2003 – October 2006 Princeton University, Princeton, NJ NIH NRSA Postdoctoral Fellow August 2001 – June 2003 Advisor: Professor John T. Groves California Institute of Technology, Pasadena, CA Graduate Student August 1997 – July 2001 Advisor: Professor Robert H. Grubbs Yale University, New Haven, CT Undergraduate Student September 1994 – June 1996 Advisor: Professor Robert H. Crabtree Naval Research Laboratory, Washington, DC Summer Intern Summer 2003, 2004, 2005 Advisor: Dr. David W. Conrad AWARDS: Honorary Doctorate, University of South - 
												
												The 1990 Nobel Prize Winners
Current CX3mrnerits” EUGENE GARFIELD INSTITUTE FCR SCIENTIFIC INFORMATGW 3YJ1 MARKET ST PHILAOELFHIA, PA 19104 The 199Q Nobel Prize Winners: A Citationist Retrospective Number 11 March 18, 1991 For more than a decade, we have devoted Before the awards were announced last essays to each year’s Nobel Prizes. These year, the biweekly newspaper ?% Scien- reports, usually published six months or tkt @ published a series of axticles in which more after the prize, have provided a unique Nobel Prize contenders were listed, based citationist perspective on the wimers. In ad- on citation frequency and predictor dition to identifying their most-cited works, awards.$7 One would think that with all of especially Citation Clussics ~, we have the non-Nobel awards that abound,g.g there highlighted work that has influenced key re- would be few recipients not in that category. search fronts.1 Nevertheless, this does occur km time to When pertinent, we’ve also listed the time. winners’ contributions to the review litera- One interesting aspect of this year’s ture. And+whe~ possible, we’ve contacted awards is the relatively low level of citations the Nobelists or close colleagues to de- for several of the winners. This could be due termine whether or not our data rein- to factors similar to those of the famous forced or contradicted perceptions of de- Watson and Crick paper in 1953,10 for layed recognition, as in the case with which they teceived the 1%2 Nobel Prize in Barbara Mc(lintock.z Her 1983 Nobel for physiology or medicine. It had been cited physiology or medicine may have been de- just under 1,100 times when we last studied layed, but she was widely recognized in the it.11This is an indication of obliteration by genetics community. - 
												
												Spring 2015 Message from the Chair Chemistry Welcomes New Faculty Member Dr
CHEM Discovery chemistry.clemson.edu Spring 2015 Message from the Chair CHEMISTRY WELCOMES NEW FACULTY MEMBER DR. CARLOS GARCIA I hope that your spirits have been re- freshed and renewed by the arrival of Spring. This is the season that brings forth budding hopes and promises of Dr. Carlos Garcia is the newest rejuvenation and new growth even addition to our program and joined though T. S. Eliot tells us “April is the the Department of Chemistry in cruelest month, … mixing memory and August of 2015. Dr. Garcia’s desire”. research lies at the interface between microfluidics and nanomaterials and is focused on the development of The faculty’s hard work over the years novel analytical has blossomed into a number of awards. strategies to The New England Regional Section of d e t e r m i n e the Society for Applied Spectroscopy biomedically- announced that Professor Ken Marcus r e l e v a n t will receive the 2015 Lester W. Strock molecules. Dr. Award at its national meeting in Sep- retiring, the department is in the midst Garcia’s group tember for “the development of the of a search for two new instructors. will continue liquid sampling-atmospheric pressure i n v e s t i g a t i n g glow discharge ionization source”. Pro- In August 2014, the department held a the driving fessor Emeritus Dwaine Eubanks was retreat to develop a new strategic plan forces and awarded the George C. Pimentel Award and a re-examination of both the un- consequences in Chemical Education for his work as dergraduate and graduate programs in of the interaction of proteins with director of the ACS Examinations In- chemistry was conducted during the nanostructured surfaces and in stitute and his work in developing text- current academic year. - 
												
												Letter from the Chair
CHEMLETTERSPRING 2017 / VOLUME XXXV NO. 1 LETTER FROM THE CHAIR Dear Friend of Chemistry, Greetings from the chair’s office to all of our alumni and friends. We do not yet know the As you read this, Spring Quarter is drawing to a close and we are details of our state budget, preparing our graduation ceremonies for the Class of 2017. Our but we anticipate continued students have made us proud again this year. Our department modest support. Thus we is strongly represented in the second cohort of the Husky 100, depend more than ever on by five students who have been recognized for their passion and the generosity of our donors leadership in applying what they learn on campus in ways that to provide the funds which make a difference in their communities and for the future. make excellence feasible. I am deeply gratified to report This is the time of year when we are working hard to recruit that Larry Dalton and Nicole graduate students to join us in September. I am pleased to report Boand have made a very that we will welcome 45 new students in the fall. This class of 21 generous commitment to the Department. This transformative gift women and 24 men comes from top universities in the U.S. (39) is described in greater detail on page 4. and abroad (6). We are always energized by the arrival of a new cohort of bright young people who bring great enthusiasm to their Thank you to all of our supporters; your annual gift of even $10 research and teaching. - 
												
												Robert Burns Woodward
The Life and Achievements of Robert Burns Woodward Long Literature Seminar July 13, 2009 Erika A. Crane “The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.” “Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect,” in Pointers and Pathways in Research (Bombay:CIBA of India, 1963). Robert Burns Woodward • Graduated from MIT with his Ph.D. in chemistry at the age of 20 Woodward taught by example and captivated • A tenured professor at Harvard by the age of 29 the young... “Woodward largely taught principles and values. He showed us by • Published 196 papers before his death at age example and precept that if anything is worth 62 doing, it should be done intelligently, intensely • Received 24 honorary degrees and passionately.” • Received 26 medals & awards including the -Daniel Kemp National Medal of Science in 1964, the Nobel Prize in 1965, and he was one of the first recipients of the Arthur C. - 
												
												Phi Beta Kappa Visiting Scholars 1956-57- 2016-2017 (61 Years)
Phi Beta Kappa Visiting Scholars 1956-57- 2016-2017 (61 years) 2016-2017 (112 visits) Adorno, Rolena Spanish/Latin American literatur Yale Bialek, William physics Princeton Ehrman, Bart D. religion, New Testament UNC-Chapel Hill Grosz, Barbara J. computer science Harvard Hochschild, Jennifer L. political science Harvard Kitcher, Philip philosophy Columbia Lester, Marsha I. chemistry Penn Morse, Nora Naranjo fine arts, poetry, sculpture Espanola, NM Rodgers, Daniel T. American history & culture Princeton Sabloff, Jeremy A. anthropology, Maya Penn Weiman, David F. economic history Barnard Wexler, Laura American studies Yale Witt, John Fabian law, American history Yale Wright, Patricia anthropology/primatology SUNY, Stony Brook Xiao, Shuhai geobiology/paleobiology Virginia Tech 2015-2016 (100 visits) Michael Bérubé English, disability studies Penn State Caroline Bruzelius art, art history Duke David K. Campbell physics, engineering Boston U. Hazel V. Carby African American studies Yale Carol Greenhouse anthropology, sociocultural Princeton David B. Grusky sociology, inequality, poverty Stanford Rigoberto Hernandez biochemistry, diversity studies Georgia Tech Mae Ngai history, Asian American studies Columbia Judith Resnik law Yale Timothy Rowe paleontology, geology UTAustin Larry A. Silver art history, Renaissance Penn Harold W. Stanley political science, elections Southern Methodist Richard Sylla American economic history NYU Blaire Van Valkenburgh vertebrate paleonbiology UCLA Vincent L. Wimbush religion Inst.SignifyingScriptures 2014-2015 (96 visits) Jeffrey C. Alexander sociology Yale William Y. Arms computer science Cornell Wendy Brown political science UCBerkeley Caroline Bruzelius art, art history Duke Philip J. Deloria history, American Indian Michigan Gerald Graff English, education Illinois at Chicago Kathleen McGarry economics, aging UCLA Gregory A. Petsko neurology, neuroscience Cornell Med. - 
												
												Carl Djerassi, Pictured Here with Artwork from His Collection
Carl Djerassi, pictured here with artwork from his collection. This sculpture, by artist Niki de Saint Phalle, is entitled “Wise Man.” Photograph by Walter van Schalkwijk. Carl Djerassi: Renaissance Scientist Par Excellence by Krishnan Rajeshwar and Walter van Schalkwijk arl Djerassi was born in Vienna, Austria, and received his Fritzsche Award (1960), Award for Creative Invention (1973), education at Kenyon College (AB summa cum laude, Award in the Chemistry of Contemporary Technological Prob- 1942) and the University of Wisconsin (PhD, 1945). After lems (1983), Priestley Medal (1992), Willard Gibbs Medal (1997), four years as research chemist with CIBA Pharmaceutical and Othmer Gold Medal (2000). Co. in Summit, New Jersey, he joined Syntex, S.A., in Carl Djerassi is a member of the U.S. National Academy of Mexico City in 1949 as associate director of chemical Sciences and of its Institute of Medicine, as well as a member of Cresearch. In 1952, he accepted a professorship at Wayne State the American Academy of Arts and Sciences, the Royal Swedish University, and in 1959 his current position as professor of Academy of Sciences, and many other learned societies. He has chemistry at Stanford University. received 18 honorary doctorate degrees from various academic Concurrently with his academic positions, he also held var- institutions around the world. ious posts at Syntex during the period 1957-1972, including that Djerassi has embarked on a second career in writing of president of Syntex Research (1968-1972). In 1968, he helped including five “science-in-fiction” novels: Cantor’s Dilemma; The found Zoecon Corporation, a company dedicated to developing Bourbaki Gambit; Marx, Deceased; Menachem’s Seed; and NO.