Ubiquitylation of P62/Sequestosome1 Activates Its Autophagy Receptor Function and Controls Selective Autophagy Upon Ubiquitin Stress
Cell Research (2017) 27:657-674. © 2017 IBCB, SIBS, CAS All rights reserved 1001-0602/17 $ 32.00 ORIGINAL ARTICLE www.nature.com/cr Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress Hong Peng1, 2, 3, *, Jiao Yang1, 2, 3, *, Guangyi Li1, 2, Qing You1, 2, Wen Han1, Tianrang Li1, Daming Gao1, Xiaoduo Xie1, Byung-Hoon Lee4, Juan Du5, Jian Hou5, Tao Zhang6, Hai Rao7, Ying Huang3, Qinrun Li1, Rong Zeng1, Lijian Hui3, Hongyan Wang1, Qin Xia8, Xuemin Zhang8, Yongning He3, Masaaki Komatsu9, Ivan Dikic10, Daniel Finley4, Ronggui Hu1 1Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, 2Graduate School, University of Chinese Academy of Sciences; 3Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China; 4Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA; 5Department of Hematology, Changzheng Hospital, The Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China; 6Department of Laboratory Medicine, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China; 7Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA; 8State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing 100850, China; 9Department of Biochemistry, School of Medicine Niigata University, 757, Ichibancho, Asahimachidori, Chuo-ku, Niigata 951-8510, Japan; 10Molecular Signaling, Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt am Main, Germany Alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood.
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