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ORAL MANIFESTATIONS of NURITIONAL DISEASES in CHILDREN Maria Bolat1, Madalina Ionela Chiriac2, Laura Trandafir3*, Anamaria Ciubara3, Smaranda Diaconescu3

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ORAL MANIFESTATIONS of NURITIONAL DISEASES in CHILDREN Maria Bolat1, Madalina Ionela Chiriac2, Laura Trandafir3*, Anamaria Ciubara3, Smaranda Diaconescu3 Romanian Journal of Oral Rehabilitation Vol. 8, No. 2, April - June 2016 ORAL MANIFESTATIONS OF NURITIONAL DISEASES IN CHILDREN Maria Bolat1, Madalina Ionela Chiriac2, Laura Trandafir3*, Anamaria Ciubara3, Smaranda Diaconescu3 1. “Gr. T. Popa" University of Medicine and Pharmacy Iași, Romania, Faculty of Dentistry, Department of Dental Materials 2. MD, Endocrinology Department of Clinical County Emergency Hospital, 400349 Cluj-Napoca, Romania 3. “Gr. T. Popa" University of Medicine and Pharmacy Iași, Romania, Mother and Child Department of Psychiatry *Corresponding author; e-mail: [email protected] , tel. +40.232 ABSTRACT Examination of the oral cavity can reveal signs and symptoms of immunologic diseases, endocrinopathies, hematologic conditions, systemic infections, and nutritional disorders. Iron deficiency anemia is present particularly in developing countries and characteristic oral manifestations include mucosal pallor, atrophic glossitis, and candidiasis. Vitamin D deficiency rickets occur in children between 3 months and 2 years old, as well as in teenagers during growth spurts which require high levels of calcium and phosphorus. The occurrence of cavities is also enabled by enamel dysplasia caused by malnutrition in the first years of life, this being a location of choice for the occurrence of cavities. Oral manifestations of malnutrition include aphthous stomatitis and atrophic glossitis caused by anemia and avitaminoses. The oral cavity plays an important part in many physiological processes represented by digestion, respiration and phonation. Oral signs frequently precede general symptoms. Physicians should be familiar with the relationship between systemic and oral health. Key words: oral manifestation, nutritional, disease INTRODUCTION breastfeeding women. Iron deficiency anemia Examination of the oral cavity can reveal affects 43% of preschoolers worldwide, signs and symptoms of immunologic particularly in developing countries, where diseases, endocrinopathies, hematologic anemia rates are four times higher than in conditions, systemic infections, and developed countries. Prevalence rates vary nutritional disorders. Careful examination depending on the sanitary and socio- should include the assessment of mucosal economic conditions and the morbidity rate. changes, periodontal inflammation and [3] In Romania, iron deficiency anemia (one of bleeding, and general condition of the teeth. the most frequent types of anemia) occurs in Identifying these oral findings may enable approximately 40% of children up to the age early diagnosis and treatment. Physicians of 5 and in 30% of pregnant women. [2, 3] should be familiar with the relationship between systemic and oral health. General Clinical Manifestations: Anemia occurs most frequently during the Iron Deficiency Anemia first years of life. Clinical manifestations Iron deficiency anemia is a major public include pallor, asthenia, inappetence, health problem and the main deficiency cephalalgia, and tachycardia, paresthesias, disease affecting children’s growth, and attention deficit. [1, 6] Fingernails become development and infection resistance, and is more brittle, flattened, and sometimes associated with a high mortality rate in become concave (koilonychia). Dysphagia children below the age of 2. [1] Iron deficiency has an irregular rate of occurrence and is anemia affect approximately 25% of the caused by the atrophy of the pharyngeal world’s population, particularly children mucosa. [1, 6] between 4 and 24 months old, young teenagers, as well as pregnant and 56 Romanian Journal of Oral Rehabilitation Vol. 8, No. 2, April - June 2016 Oral manifestations of iron deficiency The Plummer-Vinson syndrome, also anemia (Fig. 1) include mucosal pallor, called sideropenic dysphagia or sideropenic atrophic glossitis, and candidiasis. Pallor of nasopharyngopathy, is a pathologic condition the buccal mucosa and gums occurs as a that occurs in long term iron deficiency result of decreased levels of hemoglobin and anemia. In this syndrome, iron deficiency oxygen in the tissues. [2, 4, 7, 8] The general anemia is associated with the existence of atrophy of the mucosa can also be noted, symptoms and features of dysphagia, atrophic including that of the dorsal surface of the glossitis and fingernail dystrophy tongue. The tongue develops characteristic (koilonychia). Dysphagia occurs due to features of atrophic glossitis with dark red muscle degeneration, as well as due to patches and depapillation. The filiform esophageal rings – thin, ring-shaped folds of papillae of the anterior two-thirds of the the mucosa, that partially block the transport lingual mucosa are the first to be affected by of foods through the esophagus. The common atrophy. [2, 5, 8] clinical features include sore and depapillated In severe cases, the fungiform papillae are red strawberry tongue, dry mouth, spoon- also affected, so that the tongue becomes shaped fingernails and angular cheilitis. completely smooth. This generalized atrophy Atrophy leads to changes in the oral, can lead to erosions and even ulcerations with pharyngeal and upper-esophageal mucosa. chronic persistent forms. [1, 2, 4] The general symptoms include pallor, Atrophic glossitis is a nonspecific finding palpitations, fatigue and shortness of breath that can occur in association with iron (dyspnea). Many of the patients with this deficiency anemia, pernicious anemia/vitamin syndrome are edented, having lost their teeth B complex deficiencies, and various other early on. Patients frequently report sensations conditions. Oral candidiasis is another major of “throat spasms”. [10] complication of iron deficiency anemia. Oral and periodontal surgical interventions These chronic lesions can be an important should be avoided on account of the risks of factor in the occurrence of oral mucosa bleeding and delayed healing. When carcinoma, particularly in older patients. [2] hemoglobin levels drop below 10 g/dl, Angular cheilitis occurs in the oral hypoxia impairs the interactions between the commissures, with the related ulcerative cellular components of blood, particularly patches extending beyond the mucosal- platelets and endothelial cells, reducing their cutaneous junction and thus being associated hemostatic capacity. [7] with the occurrence of bleeding and pain when opening the mouth. [2, 5, 8] Vitamin D Deficiency Rickets In less severe cases, the patient may Rickets is a general nutritional condition present with burning mouth syndrome affecting the organism during rapid growth, (glossodynia), while the occurrence of caused by vitamin D deficiency and leading erosions and ulcerations are associated with to impaired metabolism of phosphorus and burning and pain, which prevent the normal calcium with deficiencies in skeletal alimentation of the child and thus create a mineralization and excessive accumulation of vicious circle. [2] osteoid tissue during the growth process Iron deficiency may also lead to atrophy of which leads to bone deformities. [11, 12] oral mucosa, because iron is essential to the Vitamin D deficiency rickets occurs in normal functioning of oral epithelial cells, children between 3 months and 2 years old, as and in an iron deficiency state, oral epithelial well as in teenagers during growth spurts cells turn over more rapidly and produce an which require high levels of calcium and atrophic or immature mucosa. [9] phosphorus. In Europe, around 50–70% of young children show signs of rickets, while Plummer-Vinson (Paterson-Kelly) 40% of teenagers present with Syndrome hypovitaminosis D. In developing countries, the prevalence of hypovitaminosis D varies 57 Romanian Journal of Oral Rehabilitation Vol. 8, No. 2, April - June 2016 largely from one region to another (from 30 Subsequent manifestations includes growth to 90%). There is a high prevalence in retardation that is also known as rachitic children in China and Mongolia, but the dwarfism. Specific bone modifications highest can be found in Africa. Risk factors include the thickening of extremities, rachitic for hypovitaminosis D in developing rosary (thickening of the chondrocostal countries are the same as those reported in junctions), thoracic deformities (protrusion of western countries and include age extremes, the sternum and ribs – pectus carinatum), females, winter season, skin pigmentation Harrison’s groove, deformities of the limbs, (African population), malnutrition, lack of and bone fractures. Cranial deformities sun exposure, high coverage clothing style, as include the asymmetric prominence of the well as obesity. In Romania, 40% of children frontal and parietal bones, occipital flattening show signs of this disorder. [12] – plagiocephaly, craniotabes – softening of the occipital bone which has the consistency General Clinical Manifestations: of a "celluloid ball" upon palpation (this Clinical manifestations range from the feature has no clinical relevance until the age mild ones such as anxiety, nocturnal of 3 months), delayed fontanel closure hyperhidrosis, unprovoked irritability, beyond the age of 18 months or, in some difficult breathing (dyspnea), muscle cramps, cases, craniosynostosis. Distended abdomen paresthesias in the extremities, sensation of occurs as a result of low muscle tone. [11] lump in one’s throat associated with The oral manifestations of vitamin D palpitations, colic abdominal pain, abdominal deficiency rickets (Fig. 2) include delays in meteorism, inappetence, precocious satiety, dental development and eruption, as well
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