VOLUME 265. NUMBER 3. JUNE 1993

JPETAB 265 (3) 1039-i 567 (1993)

ISSN 0022-3565 1Iaak MIH W 2 5 SROOKrJAIF P1A MFn: 1’h#{149}iF

The Journal of PHARMACOLOGY

AND EXPERIMENTAL THERAPEUTICS

A Publication of The American Society for Pharmacology and Experimental Therapeutics Founded by John J. Abel-1909

Edited for the Society by John A. Harvey

Published by Williams & Wilkins COPYRIGHT © 1993 BY THE AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS VIDEO TRACKERS MEASURE ANIMAL ACTIVITY Videomex-V tracks black or white images Videomex-X tracks multiple colors Can work as interfaces to IBM-PC computers

)VEI1V! Columbue Multiple Zone Dietance Traveled Experiment number 4 Dietancee are in cm VIDEQMEX-V VERTICAL ACTIVITY SETUP Timee are in meconde

c- Zone Map: HORIZONTAL -> ACTIVITY 3333 11111 44 333333 11111 444444 333333 11111 444444 333333 11111 444444 33333311111444444 333331111144444 3333111114444 MONITOR 33311111444 2222222222111i122222222221 22222222222111222222222222 - -- I 22222222222212222222222222 ---- 22222222222111222222222222 - -- 22222222221111122222222222 6tii1115 I - 666661111155555 -- - -- 66666611111555555 - - ------ 666666 11111 555555 GC6666 11111 555555 - - - CGGC66 11111 555555 ------GGGG 11111 5555 - - VERTiCAL GG 11111 55 ACTIVITY MAZES ‘ #{231}j VIDEOMEX-V VERTICAL ACTIVITY SETUP The Videomex-V is ideal for use VIDEOMEX-V SOFTWARE FOR with mazes. It prints pattern of Now, with two (2) television WATER MAZE movement, time spent in each maze cameras, the Videomex-V can branch (area), number of visits, etc This software plots patterns of movement, measures dis- measure both Horizontal and The user can design the shape of the tance traveled and time taken by the animal to reach the goal Vertical activity. platform in a Water Maze. maze and zones using a computer mouse or Videomex-V controls. NEW! !I \ ( :

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MULTIPLE ANIMALS IN MULTIPLE CAGES BACKGROUND MASKING & WATER STUDIES SMALL OBJECTS FILTER Now multiple animals in multiple cages The Videomex-V is ideal for can be measured according to patterns The Videomex-V provides the perfect method to measure measuring fish activity. Observa- of movement, distances traveled and primate activity behind cage bars by being able to “mask tions can be done either from a top time each animal spends in each zone out” areas not of interest to the study. The Videomex-V view, side view or both the side of their own cage. Each animal cage tracks the animal and measures distance traveled even with and top views of an aquarium. It can be partitioned into multiple zones. solid cage bars between the animal and television camera. can track a single fish or measure This is a very economical solution for New! Small objects can be eliminated making. Videomex-V insensitive to animal feces, tracking the general level of activity of a multiple cage studies. school of fish. only the largest object in the field. VIDEOMEX-X MULTI-COLOR SYSTEM The Videomex-X Multi-Color System can track up to 6 separate color markers on either animals or humans. It digitizes the image and calculates the X-Y coordinates of color marked objects 60 times per second and transfers the data in real time to an IBM-PC/AT’s hard disk. It’s ideal for tracking multiple animal activity when animals share the same space. Software is available for tracking patterns of movement, social contact, distance traveled, time spent in different zones, etc. One exceptional application for this is in human biomechanics. LAB ANIMAL RESEARCH EQUIPMENT CATALOG NOW AVAILABLE. PLEASE CONTACT US FOR MORE INFORMATION AT: COLUMBUS INSTRUMENTS INTERNATIONAL CORPORATION

P.O. Box 44049 Columbus, Ohio 43204 USA PH: (614) 276-0861 FAX: (614) 276-0529 TLX: 246514 Toll Free In USA: 1-800-669-5011 The Editor of The Journal of Pharmacology and Experimental Therapeutics wishes to express appreciation to the following colleagues who acted as Guest Editors for Specific Fields in 1992.

Martin W. Adler Kenneth Johnson Edson X. Albuquerque Rudolph L. Juliano Lewis Aronow David D. Ku Carl K. Buckner John S. Lazo Marie Francoise Chesselet Irwin Lucki Theodore J. Cicero Donald E. McMillan David E. Clarke Lawrence Middaugh Marlene L. Cohen William H. Morse Max Costa David L. Nelson Charles R. Craig Saul M. Schanberg Stephen K. Fisher Kenneth J. Simansky Alan Frazer Roger D. Spealman Ray W. Fuller Jack W. Strandhoy Gerald L. Gebber Boris Tabakoff Stephen G. Holtzman R. Clinton Webb E. H. Jeffrey Michael Williams

Additionally, sincere thanks are due to 1060 of our colleagues not on the Editorial Advisory Board who reviewed articles for the Journal in 1992. Their contributions are acknowledged individually in the Annual Report of The Journal to The Board of Publications Trustees of The American Society for Pharmacology and Experimental Therapeutics. INDEX

Volume 265, April-June, 1993

A231877, endothelium-dependent relaxa- anisms in myocytes (guinea pigs), propranobol plasma concentration tion of aorta, L- and D-enantiomers, 1527 (humans), 681 NGnitroarginine (rats), 112 Acylcarnitines, long-chain, permeability immunomodulatory effects, morphine Abe, Y., Kitada, Y. and Narimatsu, A.: Ef- and morphology, colonic mucosa (rats), 1079 fect of MCI-154, a cardiotonic agent, (rats), 955 inotropic and beta blocking effects, chi- on regional contractile function and AD-5423, haloperidol and, pharmacological meric molecule (dogs), 1105 myocardial oxygen consumption in activities, antipsychotic efficacy and/ beta-i, mechanism of action, denopamine the presence and absence of coronary or adverse side effects (rats), 745 (rabbits), 1292 artery stenosis in dogs, 819 Adenine, pharmacological characterization beta-i and beta-2, desensitization, lipo- Abreu, M. E., see Clissold, D. B., 876 of N-0840, 227 lytic responses of adipocytes (ham- Abreu, M. E., see Karbon, E. W., 866 Adenosine sterS), 237 Absence, precipitated agonists, ventilation effects (monkeys), beta-2, independent relaxation in aorta, chronic diazepam (dogs), 1152 971 tyramine (rats), 1096 concentration-response curves, opiate-dc- Al-selective agonist RG14202 (pigs), 699 beta prejunctional, modulation of sympa- pendent ileum (guinea pigs), 1519 effects of lemakalim, comparison of vaso- thetic neurotransmission, mesentery Acetylcholine dilators (dogs), 1026 (rats), 657 cholinergic interaction, atpha-2 adreno- metabolite, inhibition, proliferation of comparison of vasodilators, lemakalim ceptor-mediated antinociception nontransformed cells (mice), 790 (dogs), 1026 (sheep), 536 Adenosine triphosphatase, inhibitors, inhi- contractile responses in vas deferens, effects of lemakalim, comparison of vaso- bition of relaxation, nitroglycerin atrial natriuretic peptide, inhibition dilators (dogs), 1026 and atrial natriuretic factor (rabbits), of purinergic component (guinea endothelium-dependent relaxation of 1187 pigs), 920 aorta, L- and D-enantiomers, N’-ni- Adenosine triphosphate pharmacokinetics and pharmacody- tro-arginine (rats), 112 P2 purinergic receptors namics, normal children and adoles- extracellular human breast tumor cells, 1499 cents, 1232 increased levels, sigma ligands in fron- pharmacological characterization, re- Adrenochrome, implication of oxygen radi- tal cortex (rats), 851 novasculature (rats), 334 cals, metabolism of cycbosporine A microdialysis, 1,2,3,4-tetrahydro-9- -sensitive potassium channel and FK-506, liver microsomes (rats, aminoacridine, striatum (rats), 759 action potential durations, minoxidil humans), 1047 pharmacological characterization, reno- sulfate-induced shortening (guinea Aging, stereoselective pharmacokinetics and vascular P2 purinergic receptors pigs), 1527 pharmacodynamics, verapamil (hu- (rats), 334 blocker glyburide, natriuretic proper- mans), 690 receptors and nicotinic binding sites, ties (rats), 933 Ahmed, S. S., Strobe!, H. W., Napoli, K. L. neuroblastoma clone line (humans), cardioprotection with zofenopril, myo- and Grevel, J.: Adrenochrome reac- 294 cardial ischemia (rats), 609 tion implicates oxygen radicals in responses of circular myometrium, pro- no abolishment of preconditioning, is- metabolism of cyclosporine A and gesterone and mifepristone, oxytocin chemic heart (rats), 559 FK-506 in rat and human liver mi- (rats), 1205 relaxation of coronary arteries, calci- crosomes, 1047 N-Acetylcysteine, inhibition of angiotensin tonin gene-related peptide (pigs), 490 AIDS, gastrointestinal and hepatic first- converting enzyme (rats), 1239 Adenylate cyclase, short-term desensitiza- pass elimination, 2’,3’-dideoxyino- N-Acetyl fl-endorphin(1-31), substance P tion, muscarinic m2 receptors, cere- sine (rats), 731 and, supraspinal antinociception, mu bellar granule cells (rats), 433 Airway, smooth muscle, functional role, opioid and alpha-2 adrenoceptors Adipocytes, lipolytic responses, desensiti- phosphodiesterase isozymes (hu- (mice), 835 zation, beta-i and beta-2 adrenocep- mans), 1213 N-Acetyl-neurotensin(8-13), inhibition of tors (hamsters), 237 Akaike, A., see Tamura, Y., 1017 vascular leakage, tissue injury (rats), Adrenal gland, pharmacological character- Albuquerque, E. X., see Alkondon, M., 1455 619 ization, SR 47436 (rats, dogs, mon- Albuquerque, E. X., see Pereira, E. F. R., Acetylsalicylic acid, airway smooth muscle keys), 826 1474 function during development, Bay K Adrenoceptors Albuquerque, M. L., see Kurth, C. D., 587 8644 and CGP 28392 (guinea pigs), alpha, functional characterization, intra- Aldershvile, J., see Boesgaard, S., 1239 524 renal arteries (rabbits), 807 Aldrich, P. E., see Wong, P. C., 1088 Acid, secretion reduction by L-365,260, pre- alpha-i, pharmacology of XB513 (rats), Alhaider, A. A. and Wilcox, G. L.: Differ- vention of gastrointestinal damage, 1088 ential roles of 5-hydroxytryptamine, aspirin/ethanol/cysteamine (rats), atpha-2 and 5-hydroxytryptamine,5 receptor 1348 cholinergic interaction, antinociception subtypes in modulating spinal foci- Acidosis, extracellular, cell death, renal (sheep), 536 ceptive transmission in mice, 378 proximal tubules (rabbits), 1355 cross-tolerance with mu opioid recep- Alkondon, M. and Albuquerque, E. X.: Di- Ackerman, J. M., Johansen, P. A., Clark, D. tors, spinal cord (rats), 551 versity of nicotinic acetyicholine re- and White, F. J.: Electrophysiological supraspinal antinociception, N-acetyl ceptors in rat hippocampal neurons. effects of putative autoreceptor-se- fl-endorphin-(1-31) and substance P I. Pharmacological and functional lective dopamine agonists on AlO do- (mice), 835 evidence for distinct structural sub- pamine neurons, 963 beta types, 1455 Action potential, duration, minoxidil sul- blocker tertatolol (rats), 739 Amidase, -catalyzed hydrolysis, stereoselec- fate-induced shortening, ionic mech- dosing rate-dependent relationship, tivity in glutathione conjugation, 2- 1545 1546 Index Vol. 265

bromoisovalerylurea enantiomers neuromodulatory effects, angiotensin re- Antisense oligodeoxynucleotides, musca (rats), 1406 ceptors, vas deferens (rabbits), 601 ninic m2 receptors, short-term desen- Amiloride peptides, prostaglandin synthesis, aortic sitization, cerebellar granule cells its derivatives and, modulation, cardiac smooth muscle cells (pigs), 664 (rats), 433 performance (rats), 1280 Angiotensin converting enzyme Antonaccio, M. J., see Sargent, C. A., 609 sensitivity, indomethacin- and desamino- inhibition by N-acetylcysteine (rats), Aorta 8-D-arginine vasopressin-induced 1239 cromakalim-induced Rb efflux, inhibi- lithium reabsorption (humans), 1267 inhibitor quinapril, vasoconstrictor activ- tion by 8-(diethylamino)-octyl-3,4,5- 2-Amino-i, 4-dihydro -4-(2-4-[4-(2-methoxy- ity, mesenteric vasculature (rats), 187 tnimethoxybenzoate (rats), 1399 phenyl)- 1 -piperazinyl]butylsulfinyl- Angiotensin II discrimination of A2 adenosine receptors, phenyl)-6-methyl-5-nitro-3-pyridine nonpeptide antagonist losartan, intrinsic 2-phenylethoxy-9-methyladenine carboxylic acid bmethyl ester, see properties, glomeruli and mesangial (guinea pigs), 248 XB513 cells (rats), 1534 endothelium-dependent relaxation, L- Amino acids prevention of salt-induced hypertension, and D-enantiomens, NGnitno.argi excitatory losartan, reduced renal mass rats, nine (rats), 112 activation of nociceptive reflexes, pe- 1131 N-0861 and its enantiomens (guinea pigs), ripheral kainate receptors (rats), 927 receptor antagonist SR 47436, pharma- 201 modulation of seizure threshold, antie- cological characterization (rats, dogs, pharmacological characterization, SR pileptic drugs and chemoconvulsants monkeys), 826 47436 (rats, dogs, monkeys), 826 (mice), 1063 vasoconstrictor activity in mesenteric sancoplasmic reticulum Ca pump AT- substance P, modulation of kainic acid- vasculature, quinapril (rats), 187 Pase inhibitors, inhibition of relaxa- induced activity in spinal cord (mice), Anions tion, nitroglycerin and atrial natri- uretic factor (rabbits), 1187 159 organic, kinetic analysis of hepatobiliary release during ischemia and neuronal in- transport, Eisai hyperbilirubinemic smooth muscle, pnostaglandin synthesis, jury, effects of S-312-d, stroke-prone mutant rats, 1301 angiotensin peptides (pigs), 664 SHR rats, 463 secretion, P2 purinergic receptors, human Apoptosis, morphine-like alterations, thy- breast tumor cells, 1499 mocyte subpopubations (mice), 81 1 -Aminobenzotriazole, N-aralkyl deriva- Antiandrogens, metabolic activation of flu- Appalsamy, M., see Tseng, C.-J., 1511 tives, inhibition, pulmonary cyto- tamide, cytochromes P-450 (rats, hu- Appleby, S. D., see Lynch, J. J., Jr., 720 chrome P450 (rabbit), 281 y-Aminobutyric acid, -induced depressions mans), 366 Appleyand, S. M., see Horan, P. J., 1446 Antiarrhythmic agents, L-691,121, novel Apnikalim, Al-selective agonist RG14202 of cerebellar Purkinje neurons, sen- class III agent (guinea pigs), 720 (pigs), 699 sitization by ethanol, beta adrenergic Antibody, -forming cell response, gallium N-Analkyl-l-aminobenzotniazole, inhibition mechanisms in brain (rats), 426 arsenide-induced suppression, rever- of pulmonary cytochnome P450 (rab- 2-Aminochromomes, block ofplatelet aggre- sal by vehicle supernatants (mice), bits), 281 gation, inhibition of cAMP-depend- 144, 150 Andaillou, R., see Chansel, D., 1534 ent phosphodiesterase (humans), 457 Anticholinesterase, neostigmine, mecha- Anecoline, diversity of nicotinic acetylcho- 1-Aminocyclopropanecarboxylic acid, chronic nism of bradycardia (cats), 194 line receptors, hippocampal neurons treatment, adaptive changes, NMDA Antiepileptic agents, modulation of seizure (rats), 1455 receptor complex (mice), 1380 threshold, excitatory amino acids Argyrophilia, region-dependent damage to Aminoglutethimide, induction of cyto- (mice), 1063 central nervous system, levels above chrome P450 2B1, liver (rats), 477 Antihypertensive agents, methylated deny- brain stem, 3,3’-iminodipropionitnile Amlodipine, action on subcutaneous resist- atives, phenyl-2-aminoethyl sulfide (rats), 1492 ance arteries (humans), 860 (rats), 1113 Aromatase, inhibitor aminoglutethimide, Amphetamine, -like discriminative stimulus Antimycin A, cell death and extnacellular induction of cytochrome P450 2Bl effects, stereoisomers of deprenyl acidosis, renal proximal tubules (nab- (rats), 477 (rats), 1 bits), 1355 Arsenic, sera of gallium arsenide-exposed Analgesia Antinociception mice, inhibition of bacterial growth, medullary hyperalgesic center, pharma- alpha-2 adrenocepton-mediated, cholin- increased host resistance, 795 cological characteristics (rats), 286 ergic interaction (sheep), 536 Arterioles, cerebral, constriction, cocaine opioid receptor regulation (mice), 314 cannabinoid-induced, blockade by nor- and its metabolites (piglets), 587 supraspinal mu systems, independent binaltorphimine (mice), 633 Artery expression, genetically different cross-tolerance of mu opioid and alpha-2 antiproliferative and endothelium- mouse strains, 166 adrenergic receptors, spinal cord dependent vasodilaton properties, Anatoxin-a (rats), 551 i,3-dihydno-3-p-chloro-phenyl-7- agonist site, nicotinic acetylcholine recep- morphine-induced, antagonism, intna- hydroxy-6-methyl-furo-(3,4c)pyri- tors, hippocampal neurons (rats), cerebnoventnicular administration of dine hydrochloride (rats), 30 1474 pentobanbital (mice), 1361 cerebral, role of nitric oxide, neurogenic diversity of nicotinic acetylcholine recep- nicotinic, adrenergic, serotonengic and vasodilation (pig), 339 tors, hippocampal neurons (rats), cholinergic components (rats), 777 coronary 1455 opioid-induced, role of neurotensin, pen- Al-selective agonist RG14202 (pigs), Anday, E., see Kurth, C. D., 587 aqueducts! gray (rats), 580 699 Anderson, B., see Rampe, D., 1125 profile of biphalin (mice), 1446 comparison of vasodilators, lemakalim Anderson, D. K., see Shaffer, J. E., 1105 supraspinal, N-acetyl f3-endorphin-(i- (dogs), 1026 Anesthesia, trichloroethanol potentiation, 31), substance P (mice), 835 epinine in tissues (human), 346 5-HT3 receptor-mediated ion current, Antipsychotic agents regional contractile function, effects of nodose ganglion neurons (rats), 771 acute halopenidol administration, en- MCI-154 (dogs), 819 Anesthetics hanced dopaminergic transmission relaxation, calcitonin gene-related pep- barbiturate, depression of resting K con- (rats), 1193 tide (pigs), 490 ductance, myocardium (frog), 358 AD-5423 and habopenidol, pharmacologi- intrarenal, functional characterization, inhalational, neurochemical actions, GA- cal activities (rats), 745 alpha adrenoceptors (rabbits), 807 BAA receptor complex (mice), 1392 dopamine D,/D2 and 5-HT2 receptor oc- large vs. small, sympathetic vasomotor isoflurane, attenuation of Ca4 mobiliza- cupation (rats), 498 control, postjunctional role of neu- tion, vascular smooth muscle cells, 74 NPC 16377, behavioral and neuroprotec- nopeptide Y (rabbits), 887 Angiotensin tive profile (rats, mice, gerbils), 876 pulmonary 1993 Index 1547

endothelial cells, mechanism of putres- Baclofen, GABA autoneceptors, cerebral intravenous flumazenil (humans), cine transport (human), 60 cortex and spinal cord (rats), 765 1163 epinine in tissues (human), 346 Bacteria, inhibition of growth, gallium an- chronic diazepam, precipitated absti- subcutaneous resistance, action of amlo- senide-exposed mice, arsenic in sena, nence syndrome (dogs), 1152 dipine (humans), 860 795 Benzomonphan, increased extracellular ace- vascular postsynaptic neuropeptide Y ne- Badre, L., see Chansel, D., 1534 tylcholine levels, sigma ligands, fron- ceptor function (rats), 172 Bailey, M., see Kanbon, E. W., 866 tel cortex (rats), 851 4-(2-Arylethenyl)phenol, 2,6-disubstituted, Bakshi, V. P. and Kelley, A. E.: Feeding Benzotniazine di-N-oxide, hypoxic cell cy- prodrug, orally active 5-lipoxygenase induced by opioid stimulation of the totoxin tirapazamine, pharmacoki- inhibitor (monkeys), 483 ventral stniatum: Role of opiate ne- netics, bioreductive metabolism 2-Aryl-3-indoleacetamide, imidazopyridine ceptor subtypes, 1253 (mice), 938 derivatives and, mitochondrial diaze- Baldwin, J. J., see Lynch, J. J., Jr., 720 Benzoxazinone, 5-methyl-4H-3,i -benzoxa- pam binding inhibitor receptors Bals-Kubik, R., see Shippenbeng, T. S., 53 zin-4-one derivatives, inhibitors of (rats), 649 Balsten, R. L., see Clissold, D. B., 876 human leukocyte elastase, 516 Aspirin, prevention of gastrointestinal dam- Banejee, S. P., see Lidsky, T. I., 1193 Berg, R. A., Padbury, J. F., Donnerstein, R. age by L-365,260 (rats), 1348 Baraban, S. C., Stonnetta, R. L. and Guye- L., Klewen, S. E. and Hutten, J. J., Astrocytes, region-dependent damage to net, P. G.: Respinatory control of Jr.: Dobutamine pharmacokinetics central nervous system, levels above sympathetic nerve activity during and phanmacodynamics in normal brain stem, 3,3’-iminodipropionitnile naloxone-precipitated morphine with- children and adolescents, 1232 (rats), 1492 drawal in rats, 89 Bergman, J., see Rosenzweig-Lipson, S., Atenolol, immunomodulatory effects of Barbiturates 1039 morphine, beta adrenergic receptor anesthetics, depression of nesting K con- Bennhant, C., see Cazaubon, C., 826 (rats), 1079 ductance, myocardium (frog), 358 Berson, A., Wolf, C., Chachaty, C., Fisch, Atracunium, speed of action, neuromuscular pentobanbital dependence, behavioral ef- C., Fau, D., Eugene, D., Loepen, J., junction binding vs. buffering hy- fects, sedative drugs (baboons), 47 Gauthien, J.-C., Beaune, P., Pompon, pothesis, 1181 Barker, J. L., see Valeyev, A. Y., 985 D., Maunel, P. and Pessayne, D.: Met- Atnia, N6-endonorbornan-2-yl-methyl- Barrett, R. J., May, J. M., Martin, P. L. and abolic activation of the nitnoanomatic adenine and its enantiomers (guinea Miller, J. R.: In vitro and in vivo antiandrogen flutamide by rat and pigs), 201 pharmacological characterization of human cytochnomes P-450, including Atrial natniuretic factor, inhibition of relax- N6-cyclopentyl-9-methyladenine (N- forms belonging to the 3A and 1A ation, sarcoplasmic reticulum Ca 0840): A selective, orally active A1 subfamilies, 366 pump ATPase inhibitors, aorta (nab- adenosine receptor antagonist, 227 Bertrand, C., see Piedimonte, G., 36 bits), 1187 Banthelemy, G., see Cazaubon, C., 826 Beta adrenergic agonists, sensitization of Atnial natniuretic peptide, inhibition of pur- Basal ganglia, somatostatin receptors in nu- GABA-induced depressions, cenebel- inengic component, electrically in- cleus accumbens, locomotor activity lar Punkinje neurons, ethanol (rats), duced contractile responses, vas def- (rats), 67 426 erens (guinea pigs), 920 Basile, A. S., see Yundaydin, C., 565 Bevan, D. R., see Glavinovic, M. I., 1181 Atropine, -resistant motility, tachykinins, Baskin, E. B., see Lynch, J. J., Jr., 720 Bian, K., see Bukoski, R. D., 30 colon (guinea pigs), 1224 Bay K 8644 Bicarbonate, modulators of electrolyte Au, J. L.-S., see Bramer, S. L., 731 airway smooth muscle function, develop- transport, secretin and somatostatin, Audia, J. E., see Nelson, D. L., 1272 ment (guinea pigs), 524 gallbladder epithelium (guinea pigs), Auenbach, S. B., see Rutten, J. J., 1319 cardiovascular effects (guinea pigs), 1125 273 Ault, B. and Hildebnand, L. M.: Activation Beaudny, C., see Lugnien, C., 1142 Bijlsma, J. A., Koomans, H. A., Boer, W. of nociceptive reflexes by peripheral Beaune, P., see Benson, A., 366 H., Mees, E. J. D. and Van Rijn, kainate receptors, 927 Becker, A., see Tagani, P., 416 H. J. M.: Indomethacin- and desa- Auta, J., Romeo, E., Kozikowski, A., Ma, D., Becker, M. W., see Donn, G. W., II, 447 mino-8-D-arginine vasopressin-in- Costa, E. and Guidotti, A.: Partici- Behavior duced lithium reabsorption is not pation of mitochrondrial diazepam effects of sedative drugs, pentobanbital amilonide sensitive in humans, 1267 binding inhibitor receptors in the an- dependence (baboons), 47 BI-L-226, prodrug of 2,6-disubstituted 4-(2- ticonflict, antineophobic and anti- modification of effects, 4-pnopyl-9-hy- aryetheyl)phenol, 5-lipoxygenase in- convulsant action of 2-aryl-3-indole- droxynaphthoxazine, dopamine an- hibiton (monkeys), 483 acetamide and imidazopynidine de- tagonists (monkeys), 1039 Bile, hepatobiliary excretory function, rivatives, 649 motivational effects of opioids, neuno- chronic physical activity (rats), 321 Autoreceptors chemical substrates, mesolimbic do- Billings, B., see Yoburn, B. C., 314 y-aminobutynic acid, cerebral cortex and pamine system (rats), 53 Bilsky, E. J., see Honan, P. J., 1446 spinal cord, receptor subtypes (rats), pharmacology of NPC 17742 (mice), 1055 Bindokas, V. P., see Foucart, S., 903 765 Belandinelli, L., see Dennis, D. M., 543 Biotin, -deferoxamine derivatives, nadiola- central 5-HT1A and 5-HT1B, blocking Bend, J. R., see Mathews, J. M., 281 beling, plasma stability and pharma- properties, penbutolol (rats), 707 Benextnamine, vascular postsynaptic neu- cokinetics, 408 -selective dopamine agonists, electro- nopeptide Y receptor function (rats), Biphalin, antinociceptive profile (mice), physiological effects, AlO dopamine 172 1446 neurons (rats), 963 Benjamin, C. W., Lin, A. H., Morris, J., Birkett, D. J., see Tassaneeyakul, W., 401 Avidin, radiolabeled deferoxamine-biotin Wishka, D. G. and Gorman, R. R.: 2- Bleakman, D., see Foucart, S., 903 derivatives, plasma stability and Aminochnomones block human Blien, P., Lists, A. and Dc Montigny, C.: pharmacokinetics, 408 platelet aggregation by inhibiting Differential properties of pre- and Axon, giant, structure-activity relationship, cyclic AMP-dependent phosphodies- postsynaptic 5-hydroxtryptaminelA D-ning derivatives of grayanotoxin terase leading to reduced platelet receptors in the dorsal naphe and hip- (squid), 1328 phospholipase C activity, 457 pocampus: I. Effect of spipenone, 7 Benloucif, S., Keegan, M. J. and Galloway, Blien, P., Lists, A. and De Montigny, C.: Baba, N., see Yakehiro, M., 1328 M. P.: Senotonin-facilitated dopa- Differential properties of pre- and Bachoo, M., see Backman, S. B., 194 mine release in vivo: Pharmacological postsynaptic 5-hydroxytnyptamine1 Backman, S. B., Bachoo, M. and Polosa, C.: characterization, 373 receptors in dorsal naphe and hippo- Mechanism of the bradycandia pro- Bennett, E. H., see Lysle, D. T., 1071 campus: II. Effect of pertussis and duced in the cat by the anticholinest- Benzodiazepines cholera toxins, 16 erase neostigmine, 194 acute and repeated lonazepam exposure, Blood, levels of 1V6-phenylisopropyladeno- 1548 Index Vol. 265

sine, cardiac responses (guinea pigs), Caine self-administration, dopamine Nature and identification of nevers- 543 turnover in nucleus accumbens ing factors, 150 Blood flow, cerebral, constriction of arteni- (rats), 592 Buspirone, serotonergic involvement, halo- oles, cocaine and its metabolites (pig- medullary hyperalgesic center, pharma- penidol-induced catalepsy (rats), 207 lets), 587 cological characteristics (rats), 286 2,3-Butanedione monoxime, inhibition of Blood pressure neuronal circuits, discriminative stimulus delayed rectifier potassium channels, increased intnagastnic pressure, serotonin effects, 5-HT receptor agonists Xenopus oocytes, 1011 microinjection, nucleus raphe obscu- (rats), 572 t-Butyl hydroperoxide rus (rats), 468 sensitization of GABA-induced depnes- cell death and extracellular acidosis, renal renal function and, converting enzyme in- sions, ethanol, beta adrenergic mech- proximal tubules (rabbits), 1355 hibiton, neutral endopeptidase inhib- anisms (rats), 426 lethal injury to hepatocytes, mitochon- itor (rats), 1339 Brain stem drial and glycolytic dysfunction Blouin, R. A., see Chaudhary, I. P., 1333 mechanisms, nicotine, cardiovascular (rats), 392 BMY 14802, NPC 16377, behavioral and control (rats), 1511 Caffeine neunopnotective profile (rats, mice, region-dependent damage to central nerv- gerbils), 876 ous system, 3,3’-iminodipropionitrile drugs of abuse and cholinergic agents, Bo, J., see Bukoski, R. D., 30 (rats), 1492 delayed matching-to-sample re- sponding (monkeys), 120 Boer, W. H., see Bijlsma, J. A., 1267 Bramer, S. L., Au, J. L.-S. and Wientjes, M. Boesgaand, S., Aldenshvile, J., Poulsen, H. G.: Gastrointestinal and hepatic effects of adenosine agonists, ventilation (monkeys), 971 E., Christensen, S., Dige-Petersen, first-pass elimination of 2’,3’-di- Cagnotto, A., see Pnisco, S., 739 H. and Giese, J.: N-Acetylcysteine deoxyinosine in rats, 731 Calcitonin gene-related peptide inhibits angiotensin converting en- Brandsgaard, R. R., see Willets, J., 1055 acute effects, mechanical and electrical zyme in vivo, 1239 Breast, neoplasms, P2 puninergic receptors, responses, hemidiaphragm (rats), B#{246}hm,M., see Schwinger, R. H. G., 346 1499 1199 Bonanno, G. and Raiteni, M.: y-Aminobu- Breese, G. R., see Cniswell, H. E., 1001 relaxation of coronary arteries (pigs), 490 tynic acid (GABA) autoneceptons in Breliere, J.-C., see Cazaubon, C., 826 Calcium rat cerebral cortex and spinal cord Brideau, C., see Tagari, P., 416 agonists Bay K 8644 and CGP 28392, represent pharmacologically distinct BRL 37344, lipolytic responses of adipo- airway smooth muscle function dun- subtypes of the GABAR receptor, 765 cytes, desensitization, beta- 1 and ing development (guinea pigs), 524 Bonosky, S., see Clissold, D. B., 876 beta-2 adrenoceptors (hamsters), 237 agonist XB513, pharmacology (rats), 1088 Borosky, S., see Kanbon, E. W., 866 Brofaromine, monoamine oxidase-A inhibi- antagonist S-312-d, ischemic amino acid Bonnoni, E., see Colzi, A., i03 tors, dopamine metabolism, caudatus release and neuronal injury, stroke- Bousquet, F., see Cazaubon, C., 826 (rats), 103 prone SHR rats, 463 Bnackley, P. T. H. and Ushenwood, P. N. 2-Bromoisovalerylurea, enantiomers, gluta- attenuation of mobilization, isoflurane, R.: Are chimenic kainate/N-methyl- thione conjugation and amidase-cat- vascular smooth muscle cells, 74 D-aspartate receptors expressed in alyzed hydrolysis, liver (rats), 1406 differential effects of endothelin, gastric Xenopus oocytes from mammalian Bronchodilatons, functional role of phos- longitudinal and circular smooth and amphibian RNA?, 910 phodiesterase isozymes, airway muscle (rats), 1413 Brady, H. R., Zeidel, M. L., Kone, B. C., smooth muscle (humans), 1213 differential regulation of prostaglandin Giebisch, G. and Gullans, S. R.: Dif- Brown, M. A., see Renfro, J. L., 992 synthesis, angiotensin peptides, aor- ferential actions of cisplatin on renal Brown, R., see Burns, L. A., 795 tic smooth muscle cells (pigs), 664 proximal tubule and inner medullany Bueno, L., see Million, M., 96 intracellular signaling, P2 puninergic re- collecting duct cells, 1421 Bukoski, R. D., Bo, J., Xue, H. and Bian, ceptors, human breast tumor cells, Bradycardia K.: Antiproliferative and endothe- 1499 mechanism, anticholinesterase neostig- hum-dependent vasodilator proper- intrinsic properties of losartan, glomeruli mine (cats), 194 ties of 1,3- dihydro-3-p-chloro- and mesangial cells (rats), 1534 phenyl-7-hydroxy-6-methyl-furo-(3, UL-FS 49, increased atnial force, de- mechanism of action of denopamine, reg- creased ventricular force (dogs), 801 4c) pynidine hydrochloride, 30 ulation, myocardial contractility Bradykinin a-Bungarotoxin (rabbits), 1292 blood pressure and renal function, con- diversity of nicotinic acetylcholine recep- responses of circular myometnium, pro- verting enzyme inhibitor, neutral en- tors, hippocampal neurons (rats), gesterone and mifepnistone, oxytocin dopeptidase inhibitor (rats), 1339 1455 (rats), 1205 endothelium-dependent relaxation of ganglia-type nicotinic acetylcholine re- stimulated signal transduction, throm- aorta, L- and D-enantiomens, NGni ceptors, neuroblastoma clone line boxane A2, vascular smooth muscle tro-anginine (rats), 112 (humans), 294 (rats), 447 Brain Burns, L. A., McCay, J. A., Brown, R. and Calcium channel cerebral artery, neunogenic vasodilation, Munson, A. E.: Arsenic in the sera of action of amlodipine, subcutaneous resist- role of nitric oxide (pig), 339 gallium arsenide-exposed mice inhib- ance arteries (humans), 860 characterization of GABAA receptor- its bacterial growth and increases activators BAY K 8644 and FPL 64176, channel complex (rats), 985 host resistance, 795 cardiovascular effects (guinea pigs), constriction of cerebral arterioles, cocaine Burns, L. A. and Munson, A. E.: Gallium 1125 and its metabolites (piglets), 587 arsenide selectively inhibits T cell antagonist pimozide, block of cyclic cortical neurons, prevention of glutamate proliferation and alters expression of GMP-activated current, rod photo- cytotoxicity, ifenprodil (rats), 1017 cluster designation 25 (interleukin- receptors (frog), 626 dopamine and other mechanisms, behav- 2R/interleukin-2; ga chain), 178 block of transient current, U-88779E, ioral action of MK-801, 6-hydroxy- Burns, L. A. and Munson, A. E.: Reversal neuroblastoma cells (mice), 529 dopamine-lesioned rats, 1001 of gallium arsenide-induced suppres- Calcium channel blockers, inhibition of pur- hepatic encephalopathy, benzodiazepine sion of the antibody-forming cell re- inergic component, contractile re- receptor ligands (rats), 565 sponse by vehicle supernatants. I. sponses in vas deferens, atnial natni- 5-HTIA receptor antagonist tertatolol Pharmacokinetics after in vitro and uretic peptide (guinea pigs), 920 (rats), 739 in vivo exposure, 144 Calcium current, reduction by neuropeptide influence of estnus cycle, neurostenoid po- Burns, L. A. and Munson, A. E.: Reversal Y and pancreatic polypeptide, disso- tency, GABAA receptor complex of gallium arsenide-induced suppres- ciated neurons, superior cervical gan- (rats), 1374 sion of the antibody-forming cell re- glia (rats), 903 medial prefrontal cortex, intracranial co- sponse by vehicle supernatants. II. Calcium pump, ATPAse inhibitors, inhibi- 1993 Index 1549

tion of relaxation, nitroglycerin and candic effects, diphenyleneiodonium Churchill, P. C. and Ellis, V. R.: Phanma- atnial natriuretic factor (rabbits), (rats), 263 cological characterization of the re- 1187 intestinal mobility and nociception, Phe- novasculan P2 puninergic receptors, Calder, J. A., Schachter, M. and Seven, P. Leu-Phe-Gin-Pno-Ang-Phe-NH2 334 S.: Ion channel involvement in the amide analogs (rats), 96 Cicletanine acute vascular effects of thiazide di- region-dependent damage, levels above acute vascular effects ofthiazide diuretics, uretics and related compounds, 1175 brain stem, 3,3’-iminodipnopionitnile ion channel involvement (guinea Cambar, J., see Chansel, D., 1534 (rats), 1492 pigs), 1175 Canalicular membrane, hepatobiliary trans- Cenebellan granule cells antipnolifenative and endothelium-de- port, kinetic analysis, organic anions decreased muscaninic m2 mRNA, can- pendent vasodilaton properties, 1,3- (rats), 1301 bachol (rats), 441 dihydro-3-p-chlonophenyl-7-hy- Cannabinoids short-term desensitization, muscaninic m2 droxy-6-methyl-funo-(3,4c) pynidine -induced antinociception, blockade by receptors (rats), 433 hydrochloride (rats), 30 norbinaltorphimine (mice), 633 Cerebral cortex, spinal cord and, GABA au- Cieslinski, L. B., see Torphy, T. J., 1213 structure-activity relationships, receptor toneceptons, receptor subtypes (rats), Cisplatin, differential actions, renal proxi- binding, in vivo activities (rats), 218 765 ma! tubule, inner medullary collect- Cantnill, E., see Murray, M., 477 Cesura, A. M., see Colzi, A., 103 ing duct cells (rabbits), 1421 Caplili, H., see Schwartz, J. B., 690 C-fibers, activation of nociceptive reflexes, Clanemon, D. A., see Lynch, J. J., Jr., 720 Capsaicin peripheral kainate receptors (rats), Clank, D., see Ackerman, J. M., 963 activation of nociceptive reflexes, peniph- 927 Clank, M. A., Humphrey, S. J., Smith, M. era! kainate receptors (rats), 927 CGP 28392, airway smooth muscle function, P. and Ludens, J. H.: Unique natri- neurogenic vasodilation, neurokinin, ta- development (guinea pigs), 524 unetic properties of the ATP-sensi- chykinin receptors, nasal mucosa CGP 35348, GABA autoneceptons, cerebral tive K-channel blocker glybunide on (rats), 36 cortex and spinal cord (rats), 765 conscious rats, 933 Carbachol CGS 21680, effects of adenosine agonists, Clarke, D. E., see Hegde, S. S., 601 decreased muscarinic m2 mRNA, cerebel- ventilation (monkeys), 971 8-Cl-cyclic AMP, inhibition by adenosine lan granule cells (rats), 441 Chachaty, C., see Benson, A., 366 metabolite, proliferation of nontrans- diversity of nicotinic acetylcholine necep- Chang, S. L., see Zadina, J. E., 254 formed cells, 790 Chansel, D., Badre, L., Czekalski, S., Van- Cl-HCO3 exchanger, inhibitor of, inhibi- tons, hippocampal neurons (rats), denmeensch, S., Cambar, J. and An- tion of gastric acid secretion (mice), 1455 daillou, R.: Intrinsic properties of the 1313 -induced sodium current, ventricular nonpeptide angiotensin II antagonist Clissold, D. B., Ponteconvo, M. J., Jones, B. myocytes, guanine nucleotides losartan in glomeruli and mesangial E., Abreu, M. E., Kanbon, E. W., Er- (guinea pigs), 641 cells at high concentrations, 1534 ickson, R. H., Natalie, K. J., Jr., Bo- Carbonyl cyanide p-tnifluoromethyoxy- Chatterjee, D., see Han, Z., 790 rosky, S., Hantman, T., Mansbach, phenylhydrazone, cell death and ex- Chaudhary, I. P., Tuntatendtum, S., Mc- R. S., Balsten, R. L., Fenkany, J. W. tracellular acidosis, renal proximal Namara, P. J., Robertson, L. W. and and Enna, S. J.: NPC 16377, a potent tubules (rabbits), 1355 Blouin, R. A.: Effect of genetic obe- and selective a-ligand. II. Behavioral Cardiotonic agents, regional contractile sity and phenobanbital treatment on and neunoprotective profile, 876 function, myocardial oxygen con- the hepatic conjugation pathways, Clissold, D. B., see Kanbon, E. W., 866 sumption, MCI-154 (dogs), 819 1333 Clissold, D. B., see Willets, J., 1055 Cardiovascular system, acute opioid de- Chemoconvulsants, modulation of seizure Clonidine, alpha-2 adrenoceptor-mediated pendence, spinal rat, 128 threshold, excitatory amino acids antinociception, cholinengic interac- Carp#{233}n#{233},C., Galitzky, J., Collon, P., Escla- (mice), 1063 tion (sheep), 536 pez, F., Dauzata, M. and Lafontan, Chemotolerance, thermal tolerance and, Cocaine M.: Desensitization of beta 1- and transepithelial transport, renal epi- drugs of abuse and cholinengic agents, beta 2-, but not beta 3, adrenoceptor- thelium (flounder), 992 delayed matching-to-sample ne- mediated lipolytic responses of adi- Chemtob, S., see Varma, D. R., 1096 sponding (monkeys), 120 pocytes after long-term norepineph- Chen, F.-Y. and Lee, T. J.-F.: Role of nitric intnacnanial self-administration, medial nine infusion, 237 oxide in neunogenic vasodilation of prefrontal cortex, dopamine turnover Catalepsy, halopenidol-induced, serotonen- porcine cerebral artery, 339 in nucleus accumbens (rats), 592 gic involvement (rats), 207 Chen, J., see Simon, R. P., 24 metabolites and, constriction of cerebral Catecholamines, acute opioid dependence, Chen, Y. J., see Pierce, G. N., 1280 arterioles (piglets), 587 cardiovascular system, spinal rat, 128 Cherry, W. F., see Polhuijs, M., 1406 Cohen, M. M., see Fulginiti, J., III, 1413 Caudatus, monoamine oxidase-A inhibitors, Chiba, S., see Funukawa, Y., 801 Colbert,J.C.,seePollock,S.H., 1113 dopamine metabolism (rats), 103 Chiu, A. T., see Wong, P. C., 1088 Cole, W. C., see Pierce, G. N., 1280 Cazaubon, C., Gougat, J., Bousquet, F., Gui- Chloral hydrate, 5-HT3 receptor-mediated Collecting ducts, inner medullary and renal naudou, P., Gayraud, R., Lacoun, C., ion current, tnichlonoethanol poten- proximal tubules, differential ac- Roccon, A., Galindo, G., Barthelemy, tiation, nodose ganglion neurons tions, cisplatin (rabbits), 1421 G., Gautret, B., Bennhart, C., Per- (rats), 771 Collon, P., see Carp#{233}n#{233},C., 237 reaut, P., Breliene, J.-C., Le Fun, G. Chloride, modulators of electrolyte trans- Colon and Nisato, D.: Pharmacological port, secnetin and somatostatin, gall- mucosa, permeability and morphology, characterization of SR 47436, a new bladder epithelium (guinea pigs), 273 long-chain acylcarnitines (rats), 955 nonpeptide AT1 subtype angiotensin Chloride current, GABAA receptor-channel neflexly evoked atnopine-resistant motil- II receptor antagonist, 826 complex, characterization, brain ity, tachykinins (guinea pigs), 1224 CD25, altered expression, inhibition of T (rats), 985 Colussi, D. J., see Menkel, L. A., 699 cell proliferation, gallium arsenide Chlorpromazine, behavioral effects, pento- Colzi, A., d’Agostini, F., Cesura, A. M., Bon- (mice), 178 barbital dependence (baboons), 47 roni, E. and Da Pnada, M.: Mono. Cefodizime, kinetic analysis, hepatobiliary Cholera toxin, differential properties of 5- amine oxidase-A inhibitors and do- transport, Eisai hyperbilirubinemic HT1A receptors, dorsal naphe and hip- pamine metabolism in nat caudatus: mutant rats, 1301 pocampus (rats), 16 Evidence that an increased cytosolic Central nervous system Cholinengic agents, drugs of abuse and, de- level of dopamine displaces reversible central mu opioid receptor-mediated layed matching-to-sample respond- monoamine oxidase-A inhibitors in changes, renal function (rats), 134 ing (monkeys), 120 vivo, 103 functional integrity, presson and tachy- Christensen, S., see Boesgaand, 5., 1239 Compton, D. R., Rice, K. C., De Costa, B. 1550 Index Vol. 265

R., Razdan, R. K., Melvin, L. S., ochrome reaction, oxygen radicals duced lithium reabsorption, no ami- Johnson, M. R. and Martin, B. R.: (rats, humans), 1047 bride sensitivity (humans), 1267 Cannabinoid structure-activity nela- mitochondrial and glycolytic dysfunction, Detweilen, D. J., Eisenach, J. C. and Tong, tionships: Correlation of receptor lethal injury to hepatocytes (rats), C.: A cholinengic interaction in alpha binding and in vivo activities, 218 392 adrenoceptor-mediated antinocicep- Conotoxin, neuropeptide Y and pancreatic CYP2D1, dose- and time-dependent tion in sheep, 536 polypeptide, reduced calcium cur- changes, phencyclidine metabolite de Vry, J., see Schneiben, R., 572 rents, dissociated neurons from su- covalent binding (rats), 1261 Dexmedetomidine penior cervical ganglia (rats), 903 Cysteamine, prevention of gastrointestinal alpha-2 adrenoceptor-mediated antinoci- Conte, B., see Panlani, M., 713 damage by L-365,260 (rats), 1348 ception, cholinengic interaction Contnera, J. G., McLeskey, S. W., Holopai- Cytisine, diversity of nicotinic acetylcholine (sheep), 536 nen, I., Xu, J. and Wojcik, W. J.: receptors, hippocampal neurons cross-tolerance of mu opioid and apha-2 Muscaninic m2 receptors in cerebellan (rats), 1455 adnenengic receptors, spinal cord granule cell cultures from rat: Mech- Cytochrome P450 (rats), 551 anism of short-term desensitization, inhibition and induction of isoenzymes, N,N-Diallyl-tynosine-aib-phenylalanine- 433 lung (rats), 386 leucine ICI 174, 864, blockade of can- Converting enzyme inhibitor, neutral endo- metabolic activation of flutamide (rats, nabinoid-induced antinociception, peptidase inhibitor and, blood pres- humans), 366 norbinaltorphimine (mice), 633 sure and renal function, hypertension pulmonary, inhibition, N-aralkyl deniva- Diazepam (rats), 1339 tives of i-aminobenzotniazole (nab- binding inhibitor receptors, action of 2- Coronary vessels, discrimination of A2 aden- bits), 281 aryl-3-indoleacetamide and imidazo- osine receptors, 2-phenylethoxy-9- role of CYP2D1, phencyclidine metabo- pynidine derivatives (rats), 649 methyladenine (guinea pigs), 248 lite covalent binding, dose- and time- chronic dose, precipitated abstinence syn- Costa, E., see Auta, J., 649 dependent changes (rats), 1261 drome (dogs), 1152 Coussons, M. E., see Lysle, D. T., 1071 Cytochnome P450 1A1, 1A2 and, specificity, drugs of abuse and cholinengic agents, Cox, B. F., see Menkel, L. A., 699 substrate and inhibitor probes (hu- delayed matching-to-sample re- mans), 401 CP-55,940, cannabinoid structure-activity sponding (monkeys), 120 relationships, receptor binding, in Cytochrome P450 2B1, induction by ami- DiBona, G. F., see Kapusta, D. R., 134 vivo activities (rats), 218 noglutethimide, liver (rats), 477 Dibromosulfophthalein, kinetic analysis, CP-99,994, neunogenic vasodilation, Cytochrome P450 2C11, growth hormone- hepatobiliary transport, Eisai hyper- neurokinin1 tachykinin receptors, dependent, irreversible suppression, bilirubinemic mutant rats, 1301 nasal mucosa (rats), 36 monosodium glutamate (rats), 979 2,4-Dichlorophenoxyacetic acid, thermal Cniswell, H. E., Johnson, K. B., Mueller, R. Cytosol, monoamine oxidase-A inhibitors, and chemical tolerance, transepithe- A. and Breese, G. R.: Evidence for dopamine metabolism, caudatus hal transport, renal epithelium involvement of brain dopamine and (rats), 103 (flounder), 992 other mechanisms in the behavioral Cytotoxin, tinapazamine, phanmacokinetics, Dickenson, A. H., see Kalso, E. A., 551 action of the N-methyl-D-aspantic bioneductive metabolism (mice), 938 2’,3’-Dideoxyinosine, gastrointestinal and acid antagonist MK-801 in control Czekalski, S., see Chansel, D., 1534 hepatic first-pass elimination (rats), and 6-hydnoxydopamine-lesioned 731 rats, 1001 Dage, R. C., see Rampe, D., 1125 Dienemann, H., see Schwinger, R. H. G., Crofton, K. M., see Llonens, J., 1492 d’Agostini, F., see Colzi, A., 103 346 Cnomakalim DAMGO, induction of feeding, opioid stim- 8-(Diethylamino)-octyl-3,4,5-tnimethoxy- -induced Rb efflux, inhibition by 8-(di- ulation, ventral stniatum (rats), 1253 benzoate, inhibition of cromakalim- ethylamino)-octyl-3,4,5-tnimethoxy- Da Prada, M., see Colzi, A., 103 induced Rb efflux, aorta (rats), 1399 benzoate, aorta (rats), 1399 Dauzats, M., see Carp#{233}n#{233},C., 237 Dige-Petensen, H., see Boesgaard, S., 1239 relaxation of coronary arteries, calcitonin Davis, T. P., see Horan, P. J., 896, 1446 3,4-Dihydro-1 ‘-[2-(benzofunazan-5- gene-related peptide (pigs), 490 De Blasi, A., see Pnisco, S., 739 yl)ethyl]-6- methanesulfonamidos- Crotoxin, induction of tolerance (mice), 41 De Costa, B. R., see Compton, D. R., 218 piro[(2H)-1-benzopynan-2,4’-pipeni- Cruciani, R. A., see Valeyev, A. Y., 985 Defenoxamine, -biotin derivatives, radiola- dine]-4-one HCL, see L-691,121 Cnuz, S. L., Salazar, L. A., Fern#{225}ndez- beling, plasma stability and phanma- Dihydno-$-enythnoidine, diversity of nico- Guasti, A. and Villarneal, J. E.: Quan- cokinetics, 408 tinic acetylcholine receptors, hippo- titative analysis of concentration-re- de Groat, W. C., see Yoshiyama, M., 844 campal neurons (rats), 1455 sponse curves for precipitated absti- Delansonne, R., see El Alj, A., 1205 1,3-Dihydno-3-p-chlorophenyl-7-hydroxy-6- nence responses in the opiate-de- de Ia Roza, G., see Okamoto, M., 41 pendent guinea pig ileum, 1519 ED-Ala2, Glu4]Deltorphin, [Cys4]- and [Ser4] methyl-furo-(3,4c) pyridinehydroch- bride, antiprolifenative and endothe- Crux, S. L. and Villarreal, J. E.: Acute opioid -substituted derivatives, opioid delta hum-dependent vasodilaton proper- dependence in the cardiovascular receptor multiplicity (mice), 896 ties (rats), 30 system of the spinal nat, 128 Del Valle, J., see Wang, L., 308 Cyclic AMP De Montigny, C., see Blier, P., 7, 16 3,4-Dihydroxymethamphetamine, central -dependent phosphodiestenase, block of Dennis, D. M., Shryock, J. and Belardinelli, tryptophan hydroxylase activity platelet aggregation, 2-aminochro- L.: Correlation of (-)N6-phenyliso- (rats), 813 mones (humans), 457 propyladenosine blood levels with 3,4-Dihydnoxyphenylacetic acid, mediation modulators of electrolyte transport, secre- cardiac responses in the anesthetized of stress by 5-HT2 receptors, peniven- tin and somatostatin, gallbladder ep- guinea pig, 543 triculan hypophysial dopaminergic ithelium (guinea pigs), 273 Denopamine, mechanism of action, regula- neurons (rats), 303 relaxation of coronary arteries, calcitonin tion, myocandial contractility (rab- 4,4’-Diisothiocyanostilbene-2,2’-disulfonic gene-related peptide (pigs), 490 bits), 1292 acid, inhibition of gastric acid secre- Cyclic GMP Deprenyl, steneoisomers, amphetamine-like tion (mice), 1313 activated current discriminative stimulus effects (rats), Dikshit, M., Kumani, R. and Snimal, R. C.: block by pimozide, rod photoneceptors Pulmonary thnomboembolism-in- (frog), 626 Dermorphin, central mu opioid receptor- duced alterations in nitric oxide re- N6-Cyclopentyl-9-methyladenine, pharma- mediated changes, renal function lease from rat circulating neutro- cological characterization, 227 (rats), 134 phils, 1369 Cyclosponine A Desai, M. C., see Piedimonte, G., 36 meso-2,3-Dimercaptosuccinic acid, inhibi- metabolism in liven microsomes, adren- Desamino-8-D-anginine vasopressin, in- tion of bacterial growth, gallium ar- 1993 Index 1551

senide-exposed mice, arsenic in sena, boxane A2 stimulated signal trans- Endoh, M., see Kohi, M., 1292 795 duction in vascular smooth muscle, N6-Endonorbornan-2-yl-9-methyladenine, Dinsdale, D., see Venschoyle, R. D., 386 447 enantiomers and, atnia (guinea pigs), Diphenylmethylpiperazine, block of tnan- Dorsal naphe 201 sient calcium channel current, U- differential properties of 5-HT1A recep- Endorphin, central mu opioid receptor-me- 88779E, neuroblastoma cells (mice), tons diated changes, renal function (rats), 529 effect of pertussis and cholera toxins 134 Discriminative stimulus (rats), 16 f3-Endorphin, opioid-induced antinocicep- amphetamine-like, stereoisomers of de- effect of spiperone (rats), 7 tion, role of neurotensin, peniaque- prenyl (rats), 1 Dorsal raphe nucleus ductal gray (rats), 580 behavioral pharmacology of NPC 17742 5-HT1A receptor antagonist tertatolol Endothelial cells, pulmonary artery, mech- (mice), 1055 (rats), 739 anism of putnescine transport (hu- neunonal circuits, 5-HT receptor agonists neunonal circuits, discriminative stimulus man), 60 (rats), 572 effects, 5-HT receptor agonists Endothelin, differential effects, gastric lon- Diuretics, thiazide, acute vascular effects, (rats), 572 gitudinal and circular smooth muscle ion channel involvement (guinea Doughty, M. B., see Tessel, R. E., 172 (rats), 1413 pigs), 1175 Doxacunium, speed of action, neunomuscu- Endothelium Dix, D. I., see Jaiswal, N., 664 Ian junction binding vs. buffering hy- -dependent relaxation of aorta, L- and D- Dizoclipine, involvement ofbrain dopamine, pothesis, 1181 enantiomers, N-nitro-anginine behavioral action of MK-801, 6-hy- DPEN, induction of feeding, opioid stimu- (rats), 112 droxydopamine-lesioned rats, 1001 lation, ventral stniatum (rats), 1253 -dependent vasodilator properties, 1,3-di- DMPP, diversity of nicotinic acetylcholine Dretchen, K. L., see Fleming, N. W., 1199 hydro-3-p-chlorophenyl-7-hydroxy- receptors, hippocampal neurons Duttaroy, A., see Yoburn, B. C., 314 6-methyl-furo-(3,4c)pyridine hydro- (rats), 1455 Dykstna, L. A., see Fecho, K., 1079 chloride, antiproliferative properties DNA, fragmentation, morphine-like altera- Dykstra, L. A., see Lysle, D. T., 1071 (rats), 30 tions, thymocyte subpopulations Dynorphin A, morphine-induced antinoci- -independent relaxation of aorta, tyra- (mice), 81 ception, antagonism, intracenebro- mine (rats), 1096 Dobutamine, phanmacokinetics and phan- ventricular administration of pento- Enflunane, neurochemical actions, GABAA macodynamics, normal children and barbital (mice), 1361 receptor complex (mice), 1392 adolescents, 1232 Dzwonczyk, S., see Grover, G. J., 559 Enkephalin, analog biphalin, antinocicep- Domino, E. F. and Sheng, J.: Relative po- Dzwonczyk, S., see Sargent, C. A., 609 tive profile (mice), 1446 tency and efficacy of some dopamine Enna, S. J., see Clissold, D. B., 876 Ear, vasculature, postjunctional role, neu- agonists with varying selectivities for Enna, S. J., see Karbon, E. W., 866 nopeptide Y (rabbits), 887 D1 and D2 receptors in MPTP-in- Epidenmal growth factor, TGF-a and, inhi- Earl, R. A., see Wong, P. C., 1088 duced hemipankinsonian monkeys, bition of panietal cell function (nab- Edema, inhibition of vascular leakage, tissue 1387 bits), 308 injury, neurotensin peptides (rats), Donati, F., see Glavinovic, M. I., 1181 Epinephnine, functional integrity and CNS 619 Dong, X., see Tessel, R. E., 172 and sympathetic nervous system, Eikenburg, D. C., see Sadeghi, H. M., 657 Donnerstein, R. L., see Berg, R. A., 1232 presson and tachycardiac effects, di- Eisenach, J. C., see Detweilen, D. J., 536 phenyleneiodonium (rats), 263 Dopamine El Alj, A., Winen, N., Lallaoui, H., Delan- Epinine, cardiac inotnopic actions, coronary agonists, relative potency and efficacy, some, R., Fenne, F. and Germain, G.: MPTP-induced hemiparkinsonian Progesterone and mifepnistone mod- and pulmonary actions (human), 346 monkeys, 1387 ify principally the responses of cm- Epithelium antagonists, modification of behavioral cular myometnium to oxytocin in pre- gallbladder, modulators of electrolyte effects, 4-propyl-9-hydroxynaphthox- partunient rats: Comparison with re- transport, secretin and somatostatin azine (monkeys), 1039 sponses to acetyicholine and to (guinea pigs), 273 autonecepton-selective agonists, electro- calcium, 1205 renal, thermal and chemical tolerance, physiological effects, AlO dopamine El Amrani, A.-!. K., see Pham, I., 1339 transepithelial transport (flounder), neurons (rats), 963 Elastase, inhibitors, 5-methyl-4H-3,i-ben- 992 brain, behavioral action of MK-801, 6- zoxazin-4-one derivatives, 516 Erdmann, E., see Schwinger, R. H. G., 346 hydroxydopamine-lesioned rats, 1001 Elayan, I., Gibb, J. W., Hanson, G. R., Lim, Ergolines, species differences in pharmacol- mesolimbic system, motivational effects H. K., Foltz, R. L. and Johnson, M.: ogy, 5-HT2 receptor (rats), 1272 of opioids, neurochemical substrates Short-term effects of 2,4,5-tnihydrox- Erickson, R. H., see Clissold, D. B., 876 (rats), 53 yamphetamine, 2,4,5-tnihydnoxy- Erickson, R. H., see Kanbon, E. W., 866 metabolism in caudatus, monoamine oxi- methamphetamine and 3,4-dihydrox- Erythno-dt-1-(7-methylindan-4-yloxy)-3-is- dase-A inhibitors (rats), 103 ymethamphetamine on central tryp- opropylaminobutan-2-ol, immuno- NPC 16377 receptor binding, neunochem- tophan hydroxylase activity, 813 modulatory effects of morphine, beta ical and neunoendocnine profile (rats, Electrical resistance, transepithelial, co- adrenergic receptor (rats), 1079 mice), 866 lonic mucosa, long-chain acylcanni- Esclapez, F., see Canp#{233}n#{233},C., 237 oxidative stress and thiol modification, tines (rats), 955 Eskuni, S., see Sill, J. C., 74 chronic halopenidol administration Electrolytes, modulatons of transport, secne- Esposito, E., see Pnisco, S., 739 (rats), 1137 tin and somatostatin, gallbladder ep- Estrus cycle, influence on neurosteroid po- peniventniculan hypophysial neurons, me- ithelium (guinea pigs), 273 tency, GABAA receptor complex diation of stress, 5-HT2 receptors Electnophysiology (rats), 1374 (rats), 303 autoneceptor-selective dopamine agonists, Ethanol senotonengic involvement, haloperidol-in- AlO dopamine neurons (rats), 963 behavioral effects, pentobanbital depend- duced catalepsy (rats), 207 GABAA receptor-channel complex, char- ence (baboons), 47 serotonin-facilitated release, pharmaco- acterization, brain (rats), 985 prevention of gastrointestinal damage by logical characterization (rats), 373 inhibition of delayed rectifier potassium L-365,260 (rats), 1348 transmission, acute haloperidol adminis- channels, 2,3-butanedione monox- sensitization of GABA-induced depres- tration (rats), 1193 ime, Xenopus oocytes, 1011 sions, cenebellar Purkinje neurons, turnover in nucleus accumbens, intracra- Elliott, J. M., see Lynch, J. J., Jr., 720 brain (rats), 426 nial cocaine self-administration, me- Ellis, V. R., see Churchill, P. C., 334 2-(4-Ethyl-1-pipenazinyl)-4-(fluorophenyl)- dia! prefrontal cortex (rats), 592 Encephalopathy, hepatic, benzodiazepine 5,6,7,8,9,10-hexahydno-cycloocta[bJ Dorn, G. W., II and Becker, M. W.: Thnom- receptor ligands (rats), 565 pynidine, see AD-5423 1552 Index Vol. 265

Etorphine, opioid receptor regulation Ford-Hutchinson, A., see Tagani, P., 416 Gao, G. C. and Wei, E. T.: Xenopsin, neu- (mice), 314 Forebrain, acute uptake inhibition, extra- notensin, neurotensin(8-l3) and N- Eugene, D., see Benson, A., 366 cellular serotonin (rats), 1319 acetyl-neurotensin(8-l3) inhibit van- Evans, S. M., see Gniffiths, R. R., 1163 Forskolin, inhibition of panietal cell func- cular leakage in rats after tissue in- Ewing, R. W., see Pendley, C. E., 1348 tion, epidermal growth factor, TGF- jury, 619 Exercise, chronic physical activity, hepa- a (rabbits), 308 Gancha, R. S., Seven, P. S. and Hughes, A. tobiliany excretory function (rats), Foucart, S., Bleakman, D., Bindokas, V. P. D.: The action of amlodipine on hu- 321 and Miller, R. J.: Neunopeptide Y and man subcutaneous resistance arteries pancreatic polypeptide reduce cal- studied in vitro, 860 Farina, P. R., Graham, A. G., Homon, C. A., cium currents in acutely dissociated Garz#{243}n, J., see S#{225}nchez-Bl#{225}zquez,P., 835 Lazer, E. S., Hattox, S., Riska, P., neurons from adult rat superior cer- Gasinska, I., see Polhuijs, M., 1406 Gundel, R. H. and Wegner, C. D.: A vical ganglia, 903 Gastric acid prodrug of a 2,6-disubstituted 4-(2- Fournier, D. J., see Statkevich, P., 1118 inhibition of panietal cell function, epi- arylethenyl)phenol is a selective and Fourni#{233}-Zaluski, M.-C., see Pham, I., 1339 dermal growth factor, TGF-a (nab- orally active 5-lipoxygenase inhibi- FPL 64176, cardiovascular effects (guinea bits), 308 ton, 483 pigs), 1125 inhibition of secretion, inhibitor of C1- Farrell, G. C., see Murray, M., 477 Fras, A. M., see Wang, L., 308 HCO3 exchanger (mice), 1313 Fau, D., see Benson, A., 366 Frazer, M. J., see Pancrazio, J. J., 358 Gastrointestinal tract Fecho, K., Dykstra, L. A. and Lysle, D. T.: Fneier, D. 0 and Fuchs, B. A.: Morphine- hepatic first-pass elimination, 2’,3’-di- Evidence for beta adrenergic receptor induced alterations in thymocyte deoxyinosine (rats), 731 involvement in the immunomodula- subpopulations of B6C3F1 mice, 81 increased intragastnic pressure, senotonin tory effects of morphine, 1079 Fnenette, R., see Tagani, P., 416 microinjection into nucleus naphe ob- Feeding, induction by opioid stimulation, Freund, R. K., see Lin, A. M.-Y., 426 scunus, vagal mediation (rats), 468 ventral stniatum (rats), 1253 Fromm, C., see Yurdaydin, C., 565 prevention of damage, L-365,260 (rats), Fenflunamine, serotonergic involvement, Frontal cortex, increased extracellular ace- 1348 halopenidol-induced catalepsy (rats), tylcholine levels, sigma ligands (rats), Gauthier, J.-C., see Benson, A., 366 207 851 Gautret, B., see Cazaubon, C., 826 Fentanyl, opioid receptor regulation (mice), Fructose, mitochondnial and glycolytic dys- Gayraud, R., see Cazaubon, C., 826 314 function, lethal injury to hepatocytes Ge, L.-J., see Zadina, J. E., 254 Fenkany, J. W., see Clissold, D. B., 876 (rats), 392 Gee, K. W., see Finn, D. A., 1374 Fenkany, J. W., see Karbon, E. W., 866 Fuchs, B. A., see Freier, D. 0., 81 Gehret, J. R., see Lynch, J. J., Jr., 720 Ferkany, J. W., see Willets, J., 1055 Fujii, K., see Uejima, Y., 516 Gelboin, H. V., see Tassaneeyakul, W., 401 Fenn#{225}ndez-Guasti, A., see Crux, S. L., 1519 Fujimoto, J. M., see Wang, F. S., 1361 Gemba, T., Ninomiya, M., Matsunaga, K. Ferranio, C. M., see Jaiswal, N., 664 Fukuhara, A., see Imai, T., 328 and Ueda, M.: Effects of a novel cal- Ferre, F., see El Alj, A., 1205 Fulginiti, J., III, Cohen, M. M. and More- cium antagonist, S-(+)-methyl-4,7- Feuer, P., see Kurth, C. D., 587 land, R. S.: Endothelin differentially dihydro-3- isobutyl-6-methyl-4-(3- Field electrical stimulation, contractile ne- affects rat gastric longitudinal and nitnophenyl)thieno [2,3-b] pyridine- sponses in vas deferens, inhibition of circular smooth muscle, 1413 5-carboxylate (S-3l2-d), on ischemic puninengic component, atnial natni- $-Funaltrexamine, supraspinal mu analge- amino acid release and neuronal in- uretic peptide (guinea pigs), 920 sic systems, genetically different jury in stroke-prone, spontaneously Fink, G. D., see Kanagy, N. L., 1131 mouse strains, 166 hypertensive rats, 463 Finn, D. A. and Gee, K. W.: The influence Furman, W. R., see Gniffiths, R. R., 1163 Gene, obesity and phenobarbital treatment, of estrus cycle on neunosteroid po- Furukawa, Y., Takayama, S., Sawaki, S., hepatic conjugation pathways (rats), tency at the -y-aminobutynic acidA re- Inoue, Y. and Chiba, S.: A brady- 1333 cepton complex, 1374 candic agent, UL-FS 49, increases Genmain, G., see El Alj, A., 1205 Fioramonti, J., see Million, M., 96 atnial force and decreases ventricular Giachetti, A., see Giuliani, S., 1224 Fisch, C., see Benson, A., 366 force in isolated, perfused heart prep- Gibb, J. W., see Elayan, I., 813 Fitzpatrick, L. R., see Pendley, C. E., 1348 anations of dogs, 801 Fix, J. A., see Lecluyse, E. L., 955 Gicquel, S., see Million, M., 96 FK-506, metabolism in liven micnosomes, Galindo, G., see Cazaubon, C., 826 Giebisch, G., see Brady, H. R., 1421 adrenochnome reaction, oxygen radi- Galitzky, J., see Carp#{233}n#{233},C., 237 Giese, J., see Boesgaard, S., 1239 cals (rats, humans), 1047 Gallamine, speed of action, neuromuscular Giuliani, S., Lecci, A., Giachetti, A. and FK-1052, pharmacological characterization junction binding vs. buffering hy- Maggi, C. A.: Tachykinins and re- (rats, guinea pigs), 752 pothesis, 1181 flexly evoked atnopine-nesistant mo- Fleming, N. W., Lewis, B. K., White, D. A. Gallbladder, epithelium, modulators of elec- tility in the guinea pig colon in vivo, and Dnetchen, K. L.: Acute effects of trolyte transport, secretin and soma- 1224 calcitonin gene-related peptide on tostatin (guinea pigs), 273 G1104313, inotropic and beta blocking ef the mechanical and electrical re- Gallium arsenide fects, type III phosphodiesterase, beta sponses of the rat hemidiaphragm, -exposed mice, arsenic in sera, inhibition adrenoceptons (dogs), 1105 1199 of bacterial growth and increased Glavinovic, M. I., Law Mm, J. C., Kapural, Flezar, M. and Heisler, S.: P2-puninengic host resistance, 795 L., Donati, F. and Bevan, D. R.: receptors in human breast tumor -induced suppression of antibody-forming Speed of action of various muscle ne- cells: Coupling of intracellular cal- cell response, reversal by vehicle su- laxants at the neuromuscular junc- cium signaling to anion secretion, pennatants (mice), 144, 150 tion binding vs. buffering hypothesis, 1499 inhibition of T cell proliferation, altered 1181 Flumazenil, intravenous, acute and repeated CD25 expression (mice), 178 Glial fibnillary acidic protein, region-de- lonazepam exposure (humans), 1163 Galloway, M. P., see Benloucif, S., 373 pendent damage to central nervous Flurbiprofen Ganglia system, levels above brain stem, 3,3’- anti-inflammatory-histamine H2 antago- superior cervical, reduced calcium cur- iminodipropionitrile (rats), 1492 nist, gastric erosions (rats), 328 rents, neunopeptide Y and pancreatic Glibenclamide, ATP-sensitive potassium indomethacin and, methotnexate elimi- polypeptide (rats), 903 channel blocker, no abolishment of nation and interaction, kidney (rats), -type nicotinic acetylcholine receptors, pneconditioning, ischemic heart 1118 nicotinic binding sites, neuno- (rats), 559 Flutamide, metabolic activation, cyto- blastoma clone line (humans), 294 Glomeruli, mesangial cells and, intrinsic chromes P-450 (rats, humans), 366 Gangliosides, GM1, treatment of focal ische- properties, losartan (rats), 1534 Foltz, R. L., see Elayan, I., 813 mia (rats), 24 Glutamate 1993 Index 1553

antagonist MK-801, sites of action, mic- Growth factors, epidermal growth factor increased atnial force and decreased yen- tunition reflex (rats), 844 and TGF-a, inhibition ofpanietal cell tnicular force, UL-FS 49 (dogs), 801 cytotoxicity, prevention by ifenprodil, po- function (rabbits), 308 inotropic as well as coronary and pulmo- lyamine modulatory sites of NMDA Growth hormone, -dependent cytochrome nary actions, epinine, tissues (hu- receptors (rats), 1017 P450 2C11, irreversible suppression, man), 346 GM1 treatment of focal ischemia (rats), monosodium glutamate (rats), 979 inotnopic beta blocker, chimenic molecule 24 Gu, Z.-Q., see Yurdaydin, C., 565 (dogs), 1105 ischemic amino acid release and neunonal Guanino, J. J., see Gniffiths, R. R., 1163 ischemic, no abolishment of precondition- injury, effects of S-312-d, stroke- Guidotti, A., see Auta, J., 649 ing, glibenclamide (rats), 559 prone SHR rats, 463 Guiraudou, P., see Cazaubon, C., 826 microsomal fractions, indolidan- and no- Glutamic acid, increased intragastnic pres- Gullans, S. R., see Brady, H. R., 1421 lipram-sensitive phosphodiesterases sure, senotonin microinjection into Gundel, R. H., see Farina, P. R., 483 (dogs, humans), 1142 nucleus raphe obscurus, vagal media- Gunnell, M., see Owens, S. M., 1261 modulation of performance, amilonide tion (rats), 468 Guth, P. H., see Kaunitz, J. D., 948 and derivatives (rats), 1280 Glutathione, conjugation and amidase-cat- Guyenet, P. G., see Baraban, S. C., 89 myocardial oxygen consumption, regional alyzed hydrolysis, 2-bromoisovalery- contractile function, effects of MCI- Haaseth, R. C., see Horan, P. J., 896 lurea enantiomers, single-pass per- 154 (dogs), 819 Halaka, N. N., see Lodge, N. J., 1399 fused liven (rats), 1406 phanmacokinetics and phanmacody- Halopenidol Glybenclamide, Al-selective agonist namics, dobutamine, normal children acute administration, enhancement, do- RG14202 (pigs), 699 and adolescents, 1232 paminengic transmission (rats), 1193 Glybunide responses, N”-phenylisopnopyladenosine AD-5423 and, pharmacological activities, cromakalim-induced Rb efflux in aorta, blood levels (guinea pigs), 543 antipsychotic efficacy and/on adverse inhibition by 8-(diethylamino)octyl- Hegde, S. S. and Clarke, D. E.: Character- side effects (rats), 745 3,4,5-tnimethoxybenzoate (rats), ization of angiotensin receptors me- chronic administration, oxidative stress, 1399 diating the neuromodulatory effects thiol modification (rats), 1137 natniunetic properties (rats), 933 of angiotensin in the vas defenens of increased extracellular acetylcholine 1ev- Glycolysis, mitochondnial dysfunction and, the rabbit, 601 els, sigma ligands, frontal cortex lethal injury to hepatocytes, t-butyl- Heisler, S., see Flezar, M., 1499 (rats), 851 hydroperoxide (rats), 392 Hemicholinium-3, nicotinic antinocicep- -induced catalepsy, serotonengic involve- Goedens, N. E. and Smith, J. E.: Intracranial tion, adnenengic, serotonengic and ment (rats), 207 cocaine self-administration into the cholinergic components (rats), 777 Halothane medial prefrontal cortex increases Hemidiaphragm, mechanical and electrical barbiturate anesthetics, depression of dopamine turnover in the nucleus ac- responses, acute effects, calcitonin resting K conductance, myocandium cumbens, 592 gene-related peptide (rats), 1199 (frog), 358 Goldberg, S. R., see Yasan, S., 1 Hemipankinsonian, MPTP-induced mon- neurochemica! actions, GABAA receptor Gonzalez, W., see Pham, I., 1339 keys, relative potency and efficacy, complex (mice), 1392 Gonman, R. R., see Benjamin, C. W., 457 dopamine agonists, 1387 Hamann, S. R., see Parvini, S., 286 Goudreau, J. L., Manzananes, J., Looking- Henniksen, S. J., see Negus, S. S., 1245 Hamilton, G. S., see Willets, J., 1055 land, K. J, and Moore, K. E.: 5HT2 Hepatocytes, lethal injury by t-butylhydro- Han, Z., Chatterjee, D. and Wyche, J. H.: peroxide, mitochondrial and glyco- receptors mediate the effects of stress Proliferation of nontransformed cells on the activity of peniventniculan hy- is inhibited by adenosine metabolite lytic dysfunction (rats), 392 Herman, B., see Imberti, R., 392 pophysial dopaminergic neurons and of but not by parental 8-Cl-cyclic the secretion of a-melanoctye-stim- Heroin, reinforcing effects, effect of antag- AMP, 790 onists, opioid mu/delta/kappa (rats), ulating hormone, 303 Hanano, M., see Sathinakul, K., 1301 Gougat, J., see Cazaubon, C., 826 Hanson, G. R., see Elayan, I., 813 1245 G proteins Harris, B., Wong, G. and Skolnick, P.: Neu- Herz, A., see Shippenbeng, T. S., 53 canbachol-induced sodium current, yen- rochemical actions of inhalational Hightower, L. E., see Renfro, J. L., 992 tniculan myocytes (guinea pigs), 641 anesthetics at the GABAA receptor Hildebrand, L. M., see Ault, B., 927 differential properties of 5-HT1A necep- complex, 1392 Hippocampus tors, effect of pertussis and cholera Hart, S. D., see Wong, P. C., 1088 central 5-HTIA and 5-HT,5 autoreceptor, toxins, dorsal naphe and hippocam- Hartman, T., see Clissold, D. B., 876 blocking properties, penbutolol pus (rats), 16 Hartman, T. L., see Willets, J., 1055 (rats), 707 Graham, A. G., see Farina, P. R., 483 Hattox, S., see Farina, P. R., 483 differential properties of 5-HTIA recep- Graham, S. H., see Simon, R. P., 24 Hay, D. W. P., see Torphy, T. J., 1213 tons Grayanotoxin, D-ning derivatives, struc- Hayashi, S., Hone, M. and Okada, Y.: Ionic effect of pertussis and cholera toxins ture-activity relationship, squid giant mechanism of minoxidil sulfate-in- (rats), 16 axon, 1328 duced shortening of action potential effect of spiperone (rats), 7 Grevel, J., see Ahmed, 5. 5., 1047 durations in guinea pig ventricular ischemic amino acid release and neunonal Gniffiths, R. R., Evans, S. M., Guarino, J. myocytes, 1527 injury, effects of S-312-d, stroke- J., Roache, J. D., Furman, W. R., Heart prone SHR rats, 463 Liebson, E. and Schwam, E. M.: In- aorta and coronary vessels, discrimina- neunonal circuits, discriminative stimulus travenous flumazenil following acute tion of A2 adenosine receptors, 2- effects, 5-HT receptor agonists and repeated exposure to lorazepam phenylethoxy-9-methyladenine (rats), 572 in healthy volunteers: Antagonism (guinea pigs), 248 neurons and precipitated withdrawal, 1163 cardiovascular control, nicotine, brain agonist site, nicotinic acetylcholine re- Gniffiths, R. R., see Lamb, R. J., 47 stem mechanisms (rats), 1511 ceptors (rats), 1474 Grizzle, M. K., see Shaffen, J. E., 1105 cardiovascular effects of Ca channel ac- diversity, nicotinic acetyicholine recep- Gross, S. S., see Szab#{243},C., 674 tivators, BAY K 8644 and FPL 64176 tors (rats), 1455 Grover, G. J., Dzwonczyk, S., Sleph, P. G. (guinea pigs), 1125 Histamine and Sargent, C. A.: The ATP-sensi- electrophysiologic and antiannhythmic ac- H2 antagonist drug complex, gastric ero- tive potassium channel blocker gli- tions, L-691,121 (guinea pigs), 720 sions (rats), 328 benclamide (glybunide) does not abol- failure inhibition of panietal cell function, epi- ish preconditioning in isolated is- pharmacological characterization, SR denmal growth factor, TGF-a (rab- chemic nat hearts, 559 47436 (rats, dogs, monkeys), 826 bits), 308 Grover, G. J., see Sargent, C. A., 609 pharmacology of XB513 (rats), 1088 Hjorth, S. and Sharp, T.: In vivo microdi- 1554 Index Vol. 265

alysis evidence for central salt-induced, prevention by losartan, ne- aorta, L- and D-enantiomers, NGni serotoninlA and serotoninlB autore- duced renal mass rats, 1131 tro-arginine (rats), 112 ceptor blocking properties of the beta vasoconstnictor activity in mesentenic flurbiprofen and, methotnexate elimina- adrenoceptor antagonist (-)penbu- vasculature, quinapnil (rats), 187 tion and interaction, kidney (rats), tolol, 707 Hypothermia, cannabinoid structure-activ- 1118 Hoffman, J. I. E., see Piedimonte, G., 36 ity relationships, receptor binding, in -induced lithium reabsorption, no amilor- Holbrook, J. M., see Pollock, S. H., 1113 vivo activities (rats), 218 ide sensitivity (humans), 1267 Holopainen, I., see Contrera, J. G., 433 Hypoxia, effects of adenosine agonists, yen- prejunctional beta adrenoceptors, sympa- Holt, A. G., see Yurdaydin, C., 565 tilation (monkeys), 971 thetic neurotnansmission, mesentery Homon, C. A., see Farina, P. R., 483 (rats), 657 Ibopamine, cardiac inotropic actions, coro- Honan, P. J., Mattia, A., Bilsky, E. J., We- Inoue, Y., see Furukawa, Y., 801 nary and pulmonary actions, epinine ben, S., Davis, T. P., Yamamura, H. Interleukin 2a, altered CD25 expression, in- (human), 346 I., Malatynska, E., Appleyard, S. M., hibition of T cell proliferation, gal- ICI 174,864, blockade of cannabinoid-in- Slaninova, J., Misicka, A., Lipko- hum arsenide (mice), 178 duced antinociception, norbinaltor- swki, A. W., Hruby, V. J. and Por- Interleukins, antibody-forming cell ne- phimine (mice), 633 sponse, gallium arsenide-induced reca, F.: Antinociceptive profile of bi- Idazoxan, nicotinic antinociception, adre- suppression, reversal by vehicle su- phalin, a dimenic enkephalin analog, nergic, serotonergic and cholinergic pernatants (mice), 150 1446 components (rats), 777 Intestine, motility and nociception, Phe- Horan, P. J., Wild, K. D., Misicka, A., Lip- Ifenprodil Leu-Phe-Gin-Pro-Arg-Phe-NH2 kowski, A., Haaseth, R. C., Hruby, V. NPC 16377, behavioral and neuroprotec- amide analogs (rats), 96 J., Weber, S. J., Davis, T. P., Yama- tive profile (rats, mice, gerbils), 876 Ion channel, acute vascular effects, thiazide mura, H. I. and Porreca, F.: Agonist prevention of glutamate cytotoxicity, po- diuretics, related compounds (guinea and antagonist profiles of [D-Ala2, lyamine modulatory sites, NMDA re- pigs), 1175 Glu4]deltorphin and its [Cys4]- and ceptors in cortical neurons (rats), Ion current, 5-HT3 receptor-mediated, [Ser4];-substituted derivatives: Fur- 1017 tnichloroethanol potentiation, nodose then evidence of opioid delta receptor Ileum ganglion neurons (rats), 771 multiplicity, 896 opiate-dependent, concentration-re- Ions, minoxidil sulfate-induce shortening, Hayashi, S., 1527 Hone, M., see sponse curves, precipitated absence action potential durations, ventnicu- Hone, S., Yano, S. and Watanabe, K.: In- responses (guinea pigs), 1519 lan myocytes (guinea pigs), 1527 hibition of gastric acid secretion in pharmacological characterization of Ipsapirone, neuronal circuits, discriminative vivo and in vitro by an inhibitor of FK1052 (rats, guinea pigs), 752 stimulus effects, 5-HT receptor ago- C1-HC03 exchanger, 4,4’-diisothio- Im, H. K., Im, W. B. and Tsuzuki, K.: Se- fists (rats), 572 cyanostilbene-2,2’-disulfonic acid, lective block of transient CA channel Ischemia 1313 current in mouse neuroblastoma cells amino acid release and neunonal injury, Hone, T., see Sathirakul, K., 1301 by U-88779E, 529 effects of S-312-d, stroke-prone SHR Hornby, P. J., see Knowicki, Z. K., 468 Im, W. B., see Im, H. K., 529 rats, 463 Howell, L. L.: Effects of adenosine agonists Imai, S., see Luo, D.-L., 1187 focal, GM1 treatment (rats), 24 on ventilation during hypercapnia, Imai, T., Fukuhara, A., Ueda, I. and Otagini, Ishibashi, T., see Luo, D.-L., 1187 hypoxia and hyperoxia in rhesus M.: An evaluation of an anti-inflam- Isoflurane monkeys, 971 matory-histamine H2 antagonist drug attenuation of Ca mobilization, vascu- Hruby, V. J., see Horan, P. J., 896, 1446 complex on gastric erosions in the lan smooth muscle cells, 74 Hudzik, T. J. and Wenger, G. R.: Effects of rat, 328 neurochemical actions, GABAA receptor drugs of abuse and cholinergic agents Imberti, R., Nieminen, A.-L., Herman, B. complex (mice), 1392 on delayed matching-to-sample re- and Lemastens, J. J.: Mitochondrial Isoproterenol sponding in the squirrel monkey, 120 and glycolytic dysfunction in lethal pnejunctional beta adrenoceptors, sympa- Hughes, A. D., see Garcha, R. S., 860 injury to hepatocytes by t-butylhy- thetic neurotnansmission, mesentery Humphrey, S. J., see Clark, M. A., 933 droperoxide: Protection by fructose, (rats), 657 Husain, P. A., see Pollock, S. H., 1113 cyclosporin A and tnifluoperazine, relaxation of coronary arteries, calcitonin Husseini, W. K., see Piedimonte, G., 36 392 gene-related peptide (pigs), 490 Hutter, J. J., Jr., see Berg, R. A., 1232 Imidazopynidine, derivatives, mitochondrial sensitization of GABA-induced depres- diazepam binding inhibitor receptors Hydrochlorothiazide, acute vascular effects sions, cerebellar Purkinje neurons, (rats), 649 of thiazide diuretics, ion channel in- beta adrenergic mechanisms and 3,3’-Iminodipropionitnile, region-dependent volvement (guinea pigs), 1175 ethanol (rats), 426 damage to central nervous system, Hydrogen peroxide, cell death and extracel- Iwamoto, E. T. and Marion, L.: Adrenergic, levels above brain stem (rats), 1492 lular acidosis, renal proximal tubules serotonergic and cholinergic compo- Imipramine, chronic treatment, adaptive (rabbits), 1355 nents of nicotinic antinociception in changes, NMDA receptor complex 4-Hydroxy-a-methyl-phenyl-2-aminoethyl rats, 777 (mice), 1380 sulfide, oral antihypertensive activity Iwasa, J., see Yakehiro, M., 1328 Immune status, morphine-induced altera- (rats), 1113 tions, naltrexone (rats), 1071 Jam, S., see Pierce, G. N., 1280 Hypercapnia, hyperoxia and, effects of Immunosuppression, gallium arsenide-in- Jaiswal, N., Tallant, E. A., Jaiswal, R. K., adenosine agonists, ventilation duced suppression, antibody-forming Dix, D. I. and Fennanio, C. M.: Differ- (monkeys), 971 cell response, reversal by vehicle su- ential regulation of prostaglandin Hyperphagia, hepatobiliary excretory func- pernatants (mice), 144, 150 synthesis by angiotensin peptides in tion, chronic physical activity (rats), Indapamide, acute vascular effects of thia- porcine aortic smooth muscle cells: 321 zide diuretics, ion channel involve- Subtypes of angiotensin receptors in- Hypertension ment (guinea pigs), 1175 volved, 664 blood pressure and renal function, con- Indocyanine green, kinetic analysis, hepa- Jaiswal, R. K., see Jaiswal, N., 664 verting enzyme inhibitor, neutral en- tobiliary transport, Eisai hypenbili- Johansen, P. A., see Ackerman, J. M., 963 dopeptidase inhibitor (rats), 1339 rubinemic mutant rats, 1301 Johnson, A. L., see Wong, P. C., 1088 effects of nicotine, brain stem mecha- Indolidan, -sensitive cyclic nucleotide phos- Johnson, K. B., see Cniswell, H. E., 1001 nisms, cardiovascular control (rats), phodiesterases, cardiac microsomal Johnson, M., see Elayan, I., 813 1511 fractions (dogs, humans), 1142 Johnson, M. R., see Compton, D. R., 218 pharmacological characterization, SR Indomethacin Jones, B. E., see Clissold, D. B., 876 47436 (rats, dogs, monkeys), 826 endothelium-dependent relaxation of Joyce, J. N., see Neal-Beliveau, B. 5., 207 1993 Index 1555

Jurkiewicz, N. K., see Lynch, J. J., Jr., 720 methotnexate elimination and intenac- Lemasters, J. J., see Imberti, R., 392 tion, indomethacin, flunbiprofen Lesch-Nyhan syndrome, involvement of Kachel, D. L., see Sokol, P. P., 60 (rats), 1118 brain dopamine, behavioral action of Kadowaki, M., see Nagakura, Y., 752 nenovascular system, pharmacological MK-801, 6-hydroxydopamine-le- Kageyama, M., Yanagisawa, T. and Taina, characterization, puninengic P2 recep- sioned rats, 1001 N.: Calcitonin gene-related peptide tons (rats), 334 Leukocytes, elastase inhibitors, 5-methyl- relaxes porcine coronary arteries via Kitada,Y.,seeAbe,Y., 819 4H-3,1-benzoxazin-4-one deniva- cyclic AMP-dependent mechanisms, Klewer, S. E., see Berg, R. A., 1232 tives, 516 but not activation of ATP-sensitive Kohi, M., Nonota, I., Takanashi, M. and Leukotnienes potassium channels, 490 Endoh, M.: On the mechanism of ac- generation and metabolism (dogs), 416 Kainate, NMDA receptors and, expression tion of the beta-i partial agonist den- prodrug of 2,6-disubstituted 4-(2-aryleth- in Xenopus oocytes, mammalian and opamine in regulation of myocardial enyl)phenol, 5-lipoxygenase inhibitor amphibian RNA (rats), 910 contractility: Effects on myocandial (monkeys), 483 Kainic acid, -induced activity, modulation alpha adrenoceptors and intracellular Lewis, B. K., see Fleming, N. W., 1199 in spinal cord, amino terminus of Ca transients, 1292 Li, T., see Rampe, D., 1125 substance P (mice), 159 Kohsaka, M., see Nagakuna, Y., 752 Lidsky, T. I. and Banenjee, S. P.: Acute Kaiser, C., see Karbon, E. W., 866 Kokubo, M., see Uejima, Y., 516 administration of halopenidol en- Kalso, E. A., Sullivan, A. F., McQuay, H. J., Kone, B. C., see Brady, H. R., 1421 hances dopaminengic transmission, Dickenson, A. H. and Roques, B. P.: Koob, G. F., see Negus, S. S., 1245 1193 Cross-tolerance between mu opioid Koomans, H. A., see Bijlsma, J. A., 1267 Liebson, I., see Gniffiths, R. R., 1163 and alpha-2 adrenergic receptors, but Kothstein, T., see Lynch, J. J., Jr., 720 Ligands, sigma, increased extracellular ace- not between mu and delta opioid re- Koyama, T., see Matsubana, S., 498 tylcholine levels, frontal cortex ceptors in the spinal cord of the nat, Kozikowski, A., see Auta, J., 649 (rats), 851 551 Knowicki, Z. K. and Hornby, P. J.: Sero- Lim, H. K., see Elayan, I., 813 Kanagy, N. L. and Fink, G. D.: Losartan tonin microinjected into the nucleus Lin, A. H., see Benjamin, C. W., 457 prevents salt-induced hypertension naphe obscurus increases intragastnic Lin, A. M.-Y., Freund, R. K. and Palmer, in reduced renal mass rats, 1131 pressure in the rat via a vagally me- M. R.: Sensitization of ‘y-aminobu- Kaneko, K., see Kaunitz, J. D., 948 diated pathway, 468 tynic acid-induced depressions of cer- Kapural, L., see Glavinovic, M. I., 1181 Kumani, R., see Dikshit, M., 1369 ebellar Punkinje neurons to the po- Kapusta, D. R., Obih, J. C. and DiBona, G. Kurth, C. D., Monitto, C., Albuquerque, M. tentiative effects of ethanol by beta- F.: Central mu opioid receptor-me- L., Feuer, P., Anday, E. and Shaw, adrenengic mechanisms in rat brain, diated changes in renal function in L.: Cocaine and its metabolites con- 426 conscious rats, 134 strict cerebral arterioles in newborn Lipid peroxidation, differential actions of Karbon, E. W., Abreu, M. E., Erickson, R. pigs, 587 cisplatin, inner medullary collecting H., Kaiser, C., Natalie, K. J., Jr., Kurumiya, S., see Noda, Y., 745 ducts, renal proximal tubule (nab- Clissold, D. B., Bonosky, S., Bailey, Kusumi, I., see Matsubana, S., 498 bits), 1421 M., Martin, L. A., Pontecorvo, M. J., Lipkowski, A., see Honan, P. J., 896 Enna, S. J. and Ferkany, J. W.: NPC L-365,260, reduction of basal acid secretion, Lipkowski, A. W., see Honan, P. J., 1446 16377, a potent and selective a-li- prevention of gastrointestinal dam- Lipolysis, responses of adipocytes, desensi- gand. I. Receptor binding, neuno- age, aspinin/ethanol/cysteamine tization, beta-i and beta-2 adrenocep- chemical and neuroendocrine profile, (rats), 1348 tons (hamsters), 237 866 L-691,121, cardiac electrophysiologic and Lipopolysacchanides, bacterial, induction of Karbon, E. W., see Clissold, D. B., 876 antiarrhythmic actions (guinea pigs), nitric oxide synthase, inhibition by Kashiwada, K., see Takahashi, H., 681 720 Kastin, A. J., see Zadina, J. E., 254 Laboulandine, I., see Pham, I., 1339 nifedipine (mice), 674 Kato, K., see Luo, D.-L., 1187 Lacour, C., see Cazaubon, C., 826 5-Lipoxygenase Kato, Y., see Uejima, Y., 516 Lafontan, M., see Canp#{233}n#{233},C., 237 inhibitor, pnodrug, 2,6-disubstituted 4-(2- Kaunitz, J. D., Nishizaki, Y., Kaneko, K. Lallaoui, H., see El Alj, A., 1205 arylethenyl)phenol) (monkeys), 483 and Guth, P. H.: Effect of onogastnic Lamb, R. J. and Gniffiths, R. R.: Behavioral leukotniene generation and metabolism, nicotine on rat gastric mucosal gel effects of pentobanbital, lonazepam, inhibition of MK-0591 biosynthesis thickness, surface cell viability and ethanol and chlorpnomazine substi- (dogs), 416 intracellular pH, 948 tution in pentobarbital-dependent Lists, A., see Blien, P., 7, 16 Kawabata, H., see Uejima, Y., 516 baboons, 47 Listeria monocytogenes, inhibition of bacte- Keegan, M. J., see Benloucif, 5., 373 Lange, G. D., see Valeyev, A. Y., 985 nial growth, gallium arsenide-exposed Kelley, A. E., see Bakshi, V. P., 1253 Larson, A. A. and Sun, X.: Modulation of mice, arsenic in sena, 795 Ketansenin, increased intragastnic pressure, kainic acid-induced activity in the Lithium, indomethacin-induced reabsorp- serotonin microinjection into nucleus mouse spinal cord by the amino ten- tion, desamino-8-D-arginine vaso- raphe obscurus, vagal mediation minus of substance P: Sensitivity to pressin (humans), 1267 (rats), 468 opioid antagonists, 159 Liu, K., see Pierce, G. N., 1280 Khlief, J. S., see Pollock, S. H., 1113 Lasova, L. S., see Mutafova-Yambolieva, V. Liu, S., see Schwartz, J. B., 690 Kidney N., 920 Liven blood pressure and, converting enzyme Laurenzana, E. M., see Owens, S. M., 1261 conjugation pathways, genetic obesity, inhibitor, neutral endopeptidase in- Law Mm, J. C., see Glavinovic, M. I., 1181 phenobarbital treatment (rats), 1333 hibitor (rats), 1339 Layer, R. T., see Nowak, G., 1380 first-pass elimination, 2’,3’ -dideoxyino- changes in function, central mu opioid Lazer, E. S., see Farina, P. R., 483 sine (rats), 731 receptor-mediated changes (rats), Le Bec, A., see Lugnien, C., 1142 formation and metabolism of oxazepam, 134 Lecci, A., see Giuliani, 5., 1224 nondiazepam and temazepam (mice), epithelium, thermal and chemical toler- Lecluyse, E. L., Sutton, S. C. and Fix, J. A.: 1429, 1437 ance, transepithelial transport In vitro effects of long-chain acylcar- glutathione conjugation and amidase-cat- (flounder), 992 nitines on the permeability, transep- alyzed hydrolysis, 2-bnomoisovaleryl- inner medullary collecting ducts, renal ithelial electrical resistance and mor- urea enantiomers (rats), 1406 proximal tubule, differential actions phology of rat colonic mucosa, 955 hepatobiliary transport, kinetic analysis of cisplatin (rabbits), 1421 Lee, T. J.-F., see Chen, F.-Y., 339 of organic anions, Eisai hyperbiliru- intranenal arteries, functional character- Le Fur, G., see Cazaubon, C., 826 binemic mutant rats, 1301 ization, alpha adrenoceptors (rab- Lemakalim, comparison of vasodilators induction of cytochrome P450 2B1, ami- bits), 807 (dogs), 1026 noglutethimide (rats), 477 1556 Index Vol. 265

metabolic activation of flutamide, cyto- pulmonary artery endothelial cells, mech- antagonists of A1-adenosine necep- chromes P-450 (rats, humans), 366 anism, putrescine transport (hu- tons in guinea pig isolated atnia, 201 pharmacological characterization, SR man), 60 Martin, P. L., see Barrett, R. J., 227 47436 (rats, dogs, monkeys), 826 thromboembolism-induced alterations, Martin, P. L., Ueeda, M. and Olsson, R. A.: Liver microsomes, metabolism of cyclospor- nitric oxide release, circulating neu- 2-Phenylethoxy-9-rnethyladenine: me A and FK-506, adrenochnome re- trophils (rats), 1369 An adenosine receptor antagonist action, oxygen radicals (rats, hu- Luo, D.-L., Nakazawa, M., Ishibashi, T., that discriminates between A2 aden- mans), 1047 Kato, K. and Imai, S.: Putative, Se- osine receptors in the aorta and the Llonens, J., Crofton, K. M. and O’Callaghan, lective inhibitors of sancoplasmic re- coronary vessels from the guinea pig, J. P.: Administration of 3,3’-imino- ticulum Ca-pump ATPase inhibit 248 dipropionitnile to the rat results in relaxation by nitroglycerin and atnial Martin, W. J., II, see Sokol, P. P., 60 region-dependent damage to the cen- natniuretic factor of the rabbit aorta Martin, W. R., see Parvini, S., 286 tral nervous system at levels above contracted by phenylephnine, 1187 Martin, W. R., see Sloan, J. W., 1152 the brain stem, 1492 Luttmann, M. A., see Torphy, T. J., 1213 Massaeli, H., see Pierce, G. N., 1280 Locomotor activity LY53857, nicotinic antinociception, adre- Mathews, J. M. and Bend, J. R.: N-Aralkyl cannabinoid structure-activity relation- nengic, serotonergic and cholinengic derivatives of 1 -arninobenzotniazole ships, receptor binding, in vivo activ- components (rats), 777 as potent isozyme-selective mecha- Lymphocytes, thymocyte subpopulations, ities (rats), 218 nisrn-based inhibitors of rabbit pul- morphine-like alterations (mice), 81 somatostatin receptors in nucleus accum- monary cytochnome P450 in vivo, 281 Lynch, C., III, see Pancnazio, J. J., 358 bens (rats), 67 Matsubara, R., see Matsubara, S., 498 Lynch, J. J., Jr., Wallace, A. A., Van der Lodge, N. J. and Halaka, N. N.: 8-(Dieth- Matsubara, S., Matsubara, R., Kusumi, I., Gaag, L. H., Baskin, E. B., Senik, C. ylamino)-octyl-3,4,5-trimethoxyben- Koyama, T. and Yamashita, I.: Do- M., Gehret, J. R., Kothstein, T., Stu- zoate inhibits cromakalim-induced pamine D1, D2 and senotonin2 necep- pienski, R. F., Appleby, S. D., San- Rb efflux from the rat aorta, 1399 ton occupation by typical and atypical guinetti, M. C., Jurkiewicz, N. K., Loeper, J., see Benson, A., 366 antipsychotic drugs in vivo, 498 Zingano, G. J., Stein, R. B., Clare- Longenecken, K. L., see Sokol, P. P., 60 Matsurnoto, K., see Shinayama, T., 641 mon, D. A., Elliott, J. M., Young, M. Longone, P., Mocchetti, I., Riva, M. A. and Matsunaga, K., see Gemba, T., 463 Wojcik, W. J.: Characterization of a B. and Baldwin, J. J.: Cardiac elec- trophysiologic and antianrhythmic Matsunaga, K., see Matsuno, K., 851 decrease in muscaninic m2 mRNA in Matsuno, K., Matsunaga, K., Senda, T. and actions of 3,4-dihydro-l ‘-[2-(benzo- cerebellar granule cells by carbachol, Mita, S.: Increase in extracellular furazan-5-yl)ethyl]-6 - methanesul- 441 acetylcholine level by sigma ligands Lookingland, K. J., see Goudneau, J. L., 303 fonamidospiro[(2H)-1-benzopyran- 2,4’-pipenidine]-4-one HC1 (L-691, in rat frontal cortex, 851 Lopatin, A. N. and Nichols, C. G.: 2,3-bu- Mattia, A., see Horan, P. J., 1446 tanedione monoxime (BDM) inhibi- 121), a novel class III agent, 720 Mattox, A., see Negus, S. S., 1245 tion of delayed rectifier (DRK1) po- Lysle, D. T., Coussons, M. E., Watts, V. J., Maurel, P., see Benson, A., 366 tassium channels expressed in Xen- Bennett, E. H. and Dykstra, L. A.: Morphine-induced alterations in im- May, J. M., see Barrett, R. J., 227 opus oocytes, 1011 mune status: Dose dependency, corn- May, S. W., see Pollock, S. H., 1113 Lonazepam partment specificity and antagonism McCall, D. E., see Wong, P. C., 1088 acute and repeated exposure, intravenous by naltrexone, 1071 McCay, J. A., see Burns, L. A., 795 flumazenil (humans), 1163 Lysle, D. T., see Fecho, K., 1079 MCF-7 cells, P2 puninengic receptors (hu- behavioral effects, pentobarbital depend- mans), 1499 ence (baboons), 47 Ma, D., see Auts, J., 649 MCI-154, regional contractile function, Losartan Ma, P., see Wong, P. C., 1088 rnyocardial oxygen consumption, con- intrinsic properties, glomeruli and mes- Macheney, H. J., see Sprakties, G., 273 onary artery stenosis (dogs), 819 angial cells (rats), 1534 Macnophages, induction of nitric oxide syn- McKenna, D. G., see Martin, P. L., 201 prevention of salt-induced hypertension, thase, bacterial lipopolysacchanide, McLeskey, S. W., see Contrena, J. G., 433 reduced renal mass rats, 1131 inhibition by nifedipine (mice), 674 McManus, M. E., see Tassaneeyakul, W., Lovinger, D. M. and Zhou, Q.: Tnichloroe- Maddaford, T. G., see Pierce, G. N., 1280 401 thanol potentiation of 5- Maelicke, A., see Peneina, E. F. R., 1474 McNamara, P. J., see Chaudhary, I. P., 1333 hydnoxytryptamine3 receptor-me- Maggi, C. A., see Giuliani, S., 1224 McPherson, C. D., see Pierce, G. N., 1280 diated ion current in nodose ganglion Magnesium, chimenic kainate/NMDA re- McQuay, H. J., see Kalso, E. A., 551 neurons from the adult rat, 771 ceptors, expression in Xenopus oo- MDL-72222, increased intnagastnic pres- Lucaites, V. L., see Nelson, D. L., 1272 cytes, mammalian and amphibian sure, senotonin microinjection into Lucey, M. R., see Wang, L., 308 RNA (rats), 910 nucleus naphe obscurus, vagal media- Lucki, I., see Neal-Beliveau, B. 5., 207 Mahan, L. C., see Valeyev, A. Y., 985 tion (rats), 468 Lucki, I., see Raynor, K., 67 Major, T. C., Ovenhiser, R. W., Taylor, D. Mecamylarnine, medullary hyperalgesic Ludens, J. H., see Clank, M. A., 933 G., Jr. and Panek, R. L.: Effects of center, pharmacological charactenis- Lugnien, C., Muller, B., Le Bec, A., Beaudry, quinapnil, a new angiotensin-con- tics (rats), 286 C. and Rousseau, E.: Characteriza- verting enzyme inhibitor, on vaso- Medial prefrontal cortex, intracranial co- tion of indolidan- and rolipram-sen- constrictor activity in the isolated, caine self-administration, dopamine sitive cyclic nucleotide phosphodies- perfused mesentenic vasculatune of turnover in nucleus accumbens tenases in canine and human cardiac hypertensive rats, 187 (rats), 592 microsomal fractions, 1142 Malatynska, E., see Horan, P. J., 1446 Mees, E. J. D., see Bijlsma, J. A., 1267 Lukas, R. J.: Expression of ganglia-type nic- Mansbach, R. S., see Clissold, D. B., 876 otinic acetylcholine receptors and Manzananes, J., see Goudreau, J. L., 303 a-Melanocyte-stirnulating hormone, media- nicotinic ligand binding sites by cells Manzini, S., see Panlani, M., 713 tion of stress by 5-HT2 receptors, of the IMR-32 human neuroblastoma Marion, L., see Iwamoto, E. T., 777 peniventnicular hypophysial dopami- clonal line, 294 Martin, B. J., see Yiamouyiannis, C. A., 321 nengic neurons (rats), 303 Lung Martin, B. R., see Compton, D. R., 218 Melvin, L. S., see Compton, D. R., 218 actions of epinine in tissues (human), 346 Martin, G. E., see Pendley, C. E., 1348 Mennini, T., see Pnisco, 5., 739 cytochnome P450, inhibition, N-aralkyl Martin, L. A., see Kanbon, E. W., 866 Merkel, L. A., Rivera, L. M., Colussi, D. J., derivatives of 1-aminobenzotniazole Martin, P. L., Potts, A. A., Sykes, A. M. and Pernone, M. H., Smits, G. J. and Cox, (rabbits), 281 McKenna, D. G.: (±)-N6-Endonor- B. F.: In vitro and in vivo character- inhibition and induction, cytochnome bornan-2-yl-9-methyladenine (N- ization of an Al-selective adenosine P450 isoenzymes (rats), 386 0816) and its enantiorners: Selective agonist, RG14202, 699 1993 Index 1557

Mesangial cells, glomenuli and, intrinsic injury, effects of S-312-d, stroke- malian and amphibian RNA (rats), properties, losartan (rats), 1534 prone SHR rats, 463 910 Mesentery l,2,3,4-tetnahydro-9-aminoacnidine, ex- mictunition reflex, sites of action (rats), sympathetic neurotnansmission, modula- tracellular concentration of acetyl- 844 tion by prejunctional beta adrenocep- choline, stniatum (rats), 759 Mocchetti, I., see Longone, P., 441 tors (rats), 657 Microinjection, serotonin, increased intna- Moclobemide, monoamine oxidase-A inhib- vasculatune, vasoconstnictor activity, qui- gastric pressure, nucleus naphe ob- itors, dopamine metabolism, cauda- napril (rats), 187 scums (rats), 468 tus (rats), 103 Meso-2,3-dimercaptosuccinic acid, gallium Microiotophonesis, differential properties of Molino, B. F., see Pendley, C. E., 1348 arsenide-induced suppression, anti- 5-HT1A receptors, effect of pertussis Monitto, C., see Kurth, C. D., 587 body-forming cell response, reversal and cholera toxins, dorsal naphe and Monoamine oxidase-A, inhibitors and do- by vehicle supernatants (mice), 144, hippocampus (rats), 16 pamine metabolism, caudatus (rats), 150 Microsomes, cardiac, indolidan- and roli- 103 Mesolimbic system, dopamine receptors, pram-sensitive cyclic nucleotide Monooxygenases, inhibition and induction, motivational effects of opioids, neu- phosphodiesterases (dogs, humans), cytochnome P450 isoenzymes, lung rochemical substrates (rats), 53 1142 (rats), 386 Methiothepin Mictunition Monosodium glutamate, irreversible differential properties of 5-HTIA necep- nonadrenergic and noncholinengic con- suppression, growth honmone-de- tons, effect of spipenone, dorsal raphe trol, external urethral sphincter, ni- pendent cytochrome P450 2C11 and hippocampus (rats), 7 tnic oxide (rats), 713 (rats), 979 increased intragastric pressure, serotonin reflex, effects of MK-80l, sites of action Moore, K. E., see Goudreau, J. L., 303 microinjection into nucleus raphe ob- (rats), 844 Moreland, R. S., see Fulginiti, J., III, 1413 scums, vagal mediation (rats), 468 Midazolam, morphine-induced antinocicep- Moni, J., see Nagakuna, Y., 752 Methoctnamine, nicotinic antinociception, tion, antagonism, intracenebroven- Morphine adrenergic, serotonergic and cholin- tnicular administration of pentobar- activation of nociceptive reflexes, periph- engic components (rats), 777 bits! (mice), 1361 era! kainate receptors (rats), 927 Methotnexate, elimination and interaction, Mifepnistone, progesterone and, responses acute dependence, involvement, 62 opioid indomethacin and flurbiprofen, kid- to oxytocin, circular myometnium receptors (mice), 1325 ney (rats), 1118 (rats), 1205 acute opioid dependence, cardiovascular S-(+)-Methyl-4,7-dihydro-3-isobutyl-6- Miller, D. W., see Tessel, R. E., 172 system, spinal rat, 128 methyl-4-(3-nitnopheny l)thieno[2,3- Miller, J. R., see Barrett, R. J., 227 drugs of abuse and cholinengic agents, bjpyridine-5-carboxylate, see S-312- Miller, R. J., see Foucant, S., 903 delayed matching-to-sample re- d Million, M., Fionamonti, J., Gicquel, S., Za- sponding (monkeys), 120 N-Methyl-D-aspartste jac, J. M. and Bueno, L.: Comparative immunomodulatory effects, beta adrener- antagonist NPC 17742, behavioral phan- action of Phe-Leu-Phe-Gin-Pro-Gln- gic receptor (rats), 1079 macology (mice), 1055 Ang-Phe-NH2 amide analogs on in- -induced alterations 6-hydroxydopamine-lesioned rats, in- testinal motility and nociception in immune status, naltnexone (rats), 1071 volvement of brain dopamine, behav- rats, 96 thymocyte subpopulations (mice), 81 ional action of MK-801, 1001 Miners, J. 0., see Tassaneeyakul, W., 401 -induced antinociception, antagonism, in- prevention of glutamate cytotoxicity, Minoxidil sulfate, -induced shortening of tracerebroventriculan administration ifenpnodil, cortical neurons (rats), action potential durations, ionic of pentobanbital (mice), 1361 1017 mechanisms, ventricular myocytes modulation of spinal nociceptive tnans- N-Methylcarbachol, nicotinic antinocicep- (guinea pigs), 1527 mission, 5-HT1A and 5-HT1B receptor tion, adrenergic, serotonergic and Misicka, A., see Horan, P. J., 896, 1446 subtypes (mice), 378 cholinergic components (rats), 777 Misse, G. A., see Tessel, R. E., 172 mu opiate receptor down-regulation, up- Methylglyoxalbis(guanylhydrazone), mech- Mita, S., see Matsuno, K., 851 regulation by naloxone, neuro- anism of putrescine transport, pul- Mitchell, J. A., see Szab#{243},C., 674 blastoma cells (humans), 254 monary artery endothelial cells (hu- Mitochondria naloxone-pnecipitated withdrawal, nespi- man), 60 diazepam binding inhibitor receptors, ac- natory control, sympathetic nerve ac- 5-Methyl-4H-3,1-benzoxazin-4-one, deriva- tion of 2-aryl-3-indoleacetamide and tivity (rats), 89 tives, inhibitors of human leukocyte imidazopyridine derivatives (rats), opiate-dependent ileum, concentration- elastase, 516 649 response curves, precipitated absence 1-Methyl-4-phenyl-l,2,3,6.tetnahydropyni- differential actions of cisplatin, inner responses (guinea pigs), 1519 dine, relative potency and efficacy, medullary collecting ducts, renal opioid-induced antinociception, role of dopamine agonists, hemiparkinson- proximal tubule (rabbits), 1421 neurotensin, periaqueductal gray ian monkeys, 1387 glycolytic dysfunction and, lethal injury (rats), 580 a-Methyl-phenyl-2-aminoethyl sulfide, oral to hepatocytes, t-butylhydnopenoxide opioid receptor regulation (mice), 314 antihypertensive activity (rats), 1113 (rats), 392 supraspinal mu analgesic systems, genet- Methylpnednisolone, morphine-like altera- inhibitors, cell death and extracellular ically different mouse strains, 166 tions, thymocyte subpopulations acidosis, renal proximal tubules (rab- Morris, J., see Benjamin, C. W., 457 (mice), 81 bits), 1355 Mosqueda-Gancia, R., see Tseng, C.-J., 1511 Methylscopolamine, drugs of abuse and cho- Miuna, Y., see Noda, Y., 745 Mucosa linergic agents, delayed matching-to- Miyamoto, Y., Portoghese, P. 5. and Take- colonic, permeability and morphology, sample responding (monkeys), 120 moni, A. E.: Involvement of 62 opioid long-chain acylcarnitines (rats), 955 Michel, J.-B., see Pham, I., 1339 receptors in acute dependence on gastric mucosal gel thickness, surface cell Micnodialysis morphine in mice, 1325 viability and pH, effect of orogastnic central 5-HT1A and 5-HT1B autoreceptor, MK-591, inhibition of biosynthesis, leuko- nicotine (rats), 948 blocking properties, penbutolol tniene generation and metabolism nasal, neurogenic vasodilation, (rats), 707 (dogs), 416 neurokinin, tachykinin receptors GM1 treatment of focal ischemia (rats), MK-801 (rats), 36 24 behavioral action, involvement of brain Mueller, R. A., see Cniswell, H. E., 1001 increased extracellular acetylcholine lev- dopamine, 6-hydroxydopamine-le- Mulden, G. J., see Polhuijs, M., 1406 els, sigma ligands, frontal cortex sioned rats, 1001 Muller, B., see Lugnier, C., 1142 (rats), 851 chimenic kainate/NMDA receptors, Munson, A. E., see Burns, L. A., 144, 150, ischemic amino acid release and neunonal expression in Xenopus oocytes, mam- 178, 795 1558 Index Vol. 265

Murray, M., Cantnill, E. and Farrell, G. C.: N-0840, pharmacological characterization, entiation by engolines and trypta- Induction ofcytochrome P450 2B1 in 227 mines, 1272 rat liver by the aromatase inhibitor N-0861, its enantiomers and, atnia (guinea Nelson, R., see Sill, J. C., 74 aminoglutethirnide, 477 pigs), 201 Neonates, constriction of cerebral arteni- Muscle Na7Ca exchange, amilonide and its deny- oles, cocaine and its metabolites (pig- gastric longitudinal, endothelin effects atives, modulation, cardiac perform- lets), 587 (rats), 1413 ance (rats), 1280 Neostigmine hemidiaphragm, mechanical and electni- Nadel, J. A., see Piedimonte, G., 36 alpha-2 adrenoceptor-mediated antinoci- cal responses, calcitonin gene-related Nadolol, immunomodulatory effects of mor- ception, cholinergic interaction peptide (rats), 1199 phine, beta adrenengic receptor (rats), (sheep), 536 Muscle, smooth 1079 drugs of abuse and cholinergic agents, action ofamlodipine, subcutaneous resist- Nagakura, Y., Kadowaki, M., Tokoro, K., delayed matching-to-sample ne- ance arteries (humans), 860 Tomoi, M., Moni, J. and Kohsaka, sponding (monkeys), 120 airway M.: Pharmacological characteniza- mechanism of bradycandia (cats), 194 functional role, phosphodiesterase iso- tion of FK1052, a dihydropynidoin- Nephrotoxicity, differential actions of cis- zymes (humans), 1213 dole derivative, as a new serotonin 3 platin, inner medullary collecting function during development, Bay K and 4 dual receptor antagonist, 752 ducts, renal proximal tubule (nab- 8644 and CGP 28392 (guinea pigs), Nakajima, S., see Yakehiro, M., 1328 bits), 1421 524 Nakamura, K. T., see Pichoff, B. E., 524 Neuroblastoma antiprolifenative and endothelium- Nakazawa, M., see Luo, D.-L., 1187 block of transient calcium channel cur- dependent vasodilator properties, Naloxonazine, supraspinal mu analgesic rent, U-88779E (mice), 529 1 ,3-dihydno-3-p-chlonophenyl- 7- systems, genetically different mouse clone line, ganglia-type nicotinic acetyl- hydroxy-6-methyl-funo-(3,4c)pyni- strains, 166 choline receptors (humans), 294 dine hydrochloride (rats), 30 Naloxone mu opiate receptor, up-regulation by mor- acute opioid dependence, cardiovascular phine, down-regulation by naloxone aortic, prostaglandin synthesis, angioten- system, spinal rat, 128 (humans), 254 sin peptides (pigs), 664 blockade of cannabinoid-induced antino- Neuromuscular junction circular, endothelin effects (rats), 1413 ciception, norbinaltorphimine binding or buffering hypothesis, speed of cromakalim-induced Rb efflux in aorta, (mice), 633 action, muscle relaxants, 1181 inhibition by 8-(diethylamino)-octyl- mu opiate receptor up-regulation, neuro- induction of tolerance to crotoxin (mice), 3,4,5-tnimethoxybenzoate (rats), blastoma cells (humans), 254 41 1399 nicotinic antinociception, adrenergic, se- mesentenic vasculatune, vasoconstnictor Neurons rotonergic and cholinergic compo- AlO dopamine, electrophysiologica! ef- activity, quinapril (rats), 187 nents (rats), 777 fects, autonecepton-selective agonists relaxation of coronary arteries, calcitonin opiate-dependent ileum, concentration- (rats), 963 gene-related peptide (pigs), 490 response curves, precipitated absence cerebellar Punkinje, sensitization of vascular responses (guinea pigs), 1519 GABA-induced depressions, beta ad- attenuation of Ca mobilization, opioid receptor regulation (mice), 314 renergic mechanisms in brain (rats), isoflurane, 74 -precipitated morphine withdrawal, res- 426 stimulated signal transduction, throm- piratory control, sympathetic nerve cortical, prevention of glutamate cytotox- boxane A2 (rats), 447 activity (rats), 89 icity, ifenprodil (rats), 1017 vas deferens, contractile responses, atnial Naltrexone dissociated from superior cervical ganglia, natniuretic peptide (guinea pigs), 920 medullary hyperalgesic center, pharma- reduced calcium currents, neunopep- Muscle relaxants, speed of action, neuro- cological characteristics (rats), 286 tide Y and pancreatic polypeptide muscular junction binding, buffering morphine-induced alterations of immune (rats), 903 hypothesis, 1181 status (rats), 1071 dorsal raphe and hippocampus Mutafova-Yambolieva, V. N., Venkova, K. thymocyte subpopulations (mice), 81 5-HT1A receptors, effect of spipenone M. and Lasova, L. S.: Atnial natni- Naltniben, naltnindole 5’-isothiocyanate (rats), 7 uretic peptide inhibits the puninergic and, #{244}2opioid receptors, acute de- 5-HT1A receptors, effect of pertussis and not the adrenengic component of pendence on morphine (mice), 1325 and cholera toxins (rats), 16 electrically induced contractile re- Napoli, K. L., see Ahmed, S. S., 1047 hippocampal sponses in guinea pig vas deferens, Nanimatsu, A., see Abe, Y., 819 agonist site, nicotinic acetylcholine ne- 920 Natalie, K. J., Jr., see Clissold, D. B., 876 ceptons (rats), 1474 Myocardium Natalie, K. J., Jr., see Kanbon, E. W., 866 diversity, nicotinic acetylcholine necep- contractility, mechanism of action, deno- Nathanson, J. A.: Identification of octopa- tons (rats), 1455 pamine (rabbits), 1292 minergic agonists with selectivity for injury and ischemic amino acid release, depression of resting K conductance, octopamine receptor subtypes, 509 effects of S-3l2-d, stroke-prone SHR barbiturate anesthetics (frog), 358 Natniuresis, properties of glybunide (rats), rats, 463 infarction, electrophysiologic and antiar- 933 nodose ganglion, tnichlonoethanol poten- rhythmic actions, L-691,121 (guinea Neal-Beliveau, B. S., Joyce, J. N. and Lucki, tiation, 5-HT3 receptor-mediated ion pigs), 720 I.: Serotonergic involvement in halo- current (rats), 771 ischemia, cardioprotection with zofeno- penidol-induced catalepsy, 207 peniventnicular hypophysial dopami- pnil, ATP-sensitive potassium chan- Negus, S. S., Henniksen, S. J., Mattox, A., nengic, stress, 5-HT2 receptors (rats), nel (rats), 609 Pasternak, G. W., Portoghese, P. S., 303 Myocytes Takemoni, A. E., Weingen, M. B. and Neuropeptide Y ventricular Koob, G. F.: Effect of antagonists pancreatic polypeptide and, reduction of action potential durations, minoxidil selective for mu, delta and kappa calcium currents, dissociated neurons sulfate-induced shortening (guinea opioid receptors on the reinforcing from superior cervical ganglia (rats), pigs), 1527 effects of heroin in rats, 1245 903 canbachol-induced sodium current, Nejat, R. J., see Pick, C. G., 166 postjunctional role, sympathetic vasomo- guanine nucleotides (guinea pigs), Nelson, D. L., Lucaites, V. L., Audia, J. E., ton control, large vs. small arteries 641 Nissen, J. S. and Wainscott, D. B.: (rabbits), 887 Myometnium, circular, progesterone and mi- Species differences in the pharmacol- vascular postsynaptic receptor function, fepnistone, responses to oxytocin ogy of the 5-hydroxytryptamine2 re- benextramine protection studies (rats), 1205 ceptor: Structurally specific differ- (rats), 172 1993 Index 1559

Neurostenoids, potency, influence of estrus inhibitory control of external urethral sensitization of GABA-induced depres- cycle, GABAA receptor complex sphincter (rats), 713 sions, cenebellan Punkinje neurons, (rats), 1374 pharmacological characterization, reno- beta adnenergic mechanisms and Neurotensin vascular P2 puninengic receptors ethanol (rats), 426 neunotensin(8-13) and, inhibition of vas- (rats), 334 Nonmandin, D., see Sargent, C. A., 609 cular leakage, tissue injury (rats), 619 pulmonary thromboembolism-induced al- Nonota, I., see Kohi, M., 1292 nucleus raphe magnus, opioid-induced an- tenations, release from circulating Nowak, G., see Yurdaydin, C., 565 tinociception, peniaqueductal gray neutnophils (rats), 1369 Nowak, G., Trullas, R., Layer, R. T., Skol- (rats), 580 role in neurogenic vasodilation, cerebral nick, P. and Paul, I. A.: Adaptive Neurotoxicity, region-dependent damage to artery (pig), 339 changes in the N-methyl-D-aspartate central nervous system, levels above Nitric oxide synthase receptor complex after chronic treat- brain stem, 3,3’-iminodipnopionitnile functional integrity of CNS and sympa- ment with imipramine and 1-amino- (rats), 1492 thetic nervous system, presson and cyclopropanecanboxylic acid, 1380 Neurotoxin, induction of tolerance to cro- tachycardiac effects, diphenyleneio- NPC 16377 toxin (mice), 41 donium (rats), 263 behavioral and neuroprotective profile Neunotnansmission induction by bacterial lipopolysacchanide, (mice, rats, gerbils), 876 neunomodulatory effects of angiotensin, inhibition by nifedipine (mice), 674 receptor binding, neunochemical and neu- angiotensin receptors, vas deferens NGNitnoangmnmne, L- and D-enantiomers, noendocnine profile (rats, mice), 866 (rabbits), 601 endothelium-dependent relaxation, NPC 17742, behavioral pharmacology sympathetic, mesentery, prejunctiona! aorta (rats), 112 (mice), 1055 beta adrenoceptons (rats), 657 Nitnoanomatic compounds, metabolic acti- Nucleotide phosphodiestenases, cyclic, in- Neurotransmittens, senotonin-facilitated vation of flutamide, cytochromes P- dolidan- and nolipram-sensitive, car- dopamine release, pharmacological 450 (rats, humans), 366 diac microsomal fractions (dogs, hu- mans), 1142 characterization (rats), 373 Nitroglycerin Nucleus accumbens Neutral endopeptidase inhibitor, converting effects of lemakalim, comparison of vaso- dopammne turnover, intracranial cocaine enzyme inhibitor and, blood pressure dilators (dogs), 1026 self-administration, medial prefron- and renal function, hypertension inhibition of relaxation, sancoplasmic re- tal cortex (rats), 592 (rats), 1339 ticulum Ca pump ATPase inhibi- motivational effects of opioids, neuno- Neutrophils, circulating, pulmonary thnom- tons, aorta (rabbits), 1187 Nociception chemical substrates, mesolimbic do- boembolism-induced alterations, ni- pamine system (rats), 53 tnic oxide release (rats), 1369 activation of nociceptive reflexes, peniph- somatostatin receptors, locomotor activ- Nichols, C. G., see Lopatin, A. N., 1011 era! kainate receptors (rats), 927 ity (rats), 67 Nicol, G. D.: The calcium channel antago- intestinal mobility and, Phe-Leu-Phe- Nucleus raphe magnus, opioid-induced an- nist, pimozide, blocks the cyclic Gin-Pro-Arg-Phe-NH2 amide ana- logs (rats), 96 tinociception, role of neurotensin, GMP-activated current in rod pho- peniaqueductal gray (rats), 580 toneceptons, 626 modulation of kainic acid-induced actiy- ity, amino terminus of substance P, Nucleus raphe obscurus, serotonin microin- Nicotine spinal cord (mice), 159 jection, increased intnagastric pres- antinociception, adrenergic, senotonergic sure, vagal mediation (rats), 468 and cholinengic components (rats), spinal transmission, modulation, 5-HTIA and 5-HT,5 receptor subtypes (mice), 777 Obesity, phenobarbital treatment and, he- 378 brain stem mechanisms, cardiovascular patic conjugation pathways (rats), Noda, Y., Kurumiya, S., Miura, Y. and Oka, control (rats), 1511 1333 M.: Comparative study of 2-(4-ethyl- diversity of nicotinic acetylcholine recep- Obih, J. C., see Kapusts, D. R., 134 1-pipenazinyl)-4-(fluonophenyl) -5,6, tons, hippocampal neurons (rats), O’Callaghan, J. P., see Llorens, J., 1492 7,8,9,10-hexahydro-cycloocta[b]pyni- 1455 Ochratoxin A, cell death and extracellulan dine (AD-5423) and halopenidol for drugs of abuse and cholinengic agents, acidosis, renal proximal tubules (nab- their pharmacological activities re- delayed matching-to-sample re- bits), 1355 lated to antipsychotic efficacy and/ sponding (monkeys), 120 Octopaminengic agonists, selectivity for oc- or adverse side-effects, 745 ganglia-type nicotinic acetylcholine re- topamine receptor subtypes (fireflies, Non-steroidal anti-inflammatory drugs, ceptors, neuroblastoma clone line hornworms), 509 anti-inflammatory-histamine H2 an- (humans), 294 Ogats, H., see Takahashi, H., 681 tagonist, gastric erosions (rats), 328 onogastnic, gastric mucosal gel thickness, Ogonowski, A. A., see Pollock, S. H., 1113 Norbinaltorphimine, blockade of cannabi- surface cell viability and pH (rats), 8-OH-DPAT noid-induced antinociception (mice), 948 5-HT1A receptor antagonist tertatolol, 633 pharmacological characteristics, medul- brain (rats), 739 Nondberg, A., see Xiao, W.-B., 759 lary hyperalgesic center (rats), 286 increased intragastnic pressure, senotonin Nondiazepam, temazepam and, formation microinjection into nucleus naphe ob- Nieminen, A.-L., see Imberti, R., 392 and metabolism of oxazepam, liven scurus, vagal mediation (rats), 468 Nifedipine (mice), 1429, 1437 effects of lemakalim, comparison of vaso- neuronal circuits, discriminative stimulus Norepinephnine effects, 5-HT receptor agonists dilators (dogs), 1026 constriction of cerebral arterioles, cocaine inhibition of induction of nitric oxide syn- (rats), 572 and its metabolites (piglets), 587 senotonengic involvement, halopenidol-in- thase, bacterial lipopolysacchanide functional characterization, alpha adre- duced catalepsy (rats), 207 (mice), 674 noceptors, intrarenal arteries (rab- Ohina, M., see Takahashi, H., 681 Nilutamide, metabolic activation of flutam- bits), 807 Oka, M., see Nods, Y., 745 ide, cytochnomes P-450 (rats, hu- functional integrity and CNS and sym- Okada, Y., see Hayashi, 5., 1527 mans), 366 pathetic nervous system, pnessor and Okamoto, M., Viskatis, L. J., de la Roza, G. Ninomiya, M., see Gemba, T., 463 tachycandic effects, diphenyleneio- and Vidal, J. C.: Induction of toler- Nisato, D., see Cazaubon, C., 826 donium (rats), 263 ance to crotoxin in mice, 41 Nishizaki, Y., see Kaunitz, J. D., 948 lipolytic responses of adipocytes, desen- Olsson, R. A., see Martin, P. L., 248 Nissen, J. S., see Nelson, D. L., 1272 sitization, beta-i and beta-2 adre- Oocytes Nitrate, inhibition of angiotensin convert- noceptors (hamsters), 237 Xenopus ing enzyme, N-acetylcysteine (rats), prejunctional beta adrenoceptons, sympa- chimenic kainate/NMDA receptors, 1239 thetic neunotransmission, mesentery mammalian and amphibian RNA Nitric oxide (rats), 657 (rats), 910 1560 Index Vol. 265

inhibition of delayed rectifier potas- Oxytocin, progesterone and mifepnistone, accumbens, locomotor activity (rats), sium channels, 2,3-butanedione mon- responses of circular myometnium 67 oxime, 1011 (rats), 1205 Pereina, E. F. R., Reinhardt-Maelicke, S., Opiates Schnattenholz, A., Maelicke, A. and Padbury, J. F., see Berg, R. A., 1232 acute opioid dependence, cardiovascular Albuquerque, E. X.: Identification Palmer, M. R., see Lin, A. M.-Y., 426 system, spinal rat, 128 and functional characterization of a Pamponi, N. A., see Shapiro, B. H., 979 -dependent ileum, concentration-re- new agonist site on nicotinic acetyl- Pancnazio, J. J., Fnazen, M. J. and Lynch, sponse curves, precipitated absence choline receptors of cultured hippo- C., III: Barbiturate anesthetics de- responses (guinea pigs), 1519 campal neurons, 1474 press the nesting K conductance of Opioids Peniaqueductal gray, opioid-induced antin- myocardium, 358 acute dependence, cardiovascular system, ociception, role of neurotensin, nu- Pancreas, polypeptide and neuropeptide Y, spinal rat, 128 cleus raphe magnus (rats), 580 reduction of calcium currents, disso- antagonists, modulation of kainic acid- Perreaut, P., see Cazaubon, C., 826 ciated neurons from superior cervical induced activity, spinal cord (mice), Pennone, M. H., see Merkel, L. A., 699 ganglia (rats), 903 159 Pertussis toxin Pancuronium, speed of action, neuromus- behavioral effects of sedative drugs, pen- differential properties of 5-HT1A recep- cular junction binding vs. buffering tobanbital dependence (baboons), 47 tons, dorsal raphe and hippocampus hypothesis, 1181 delta receptor multiplicity, substituted (rats), 16 Panek, R. L., see Major, T. C., 187 deltorphins (mice), 896 short-term desensitization, muscarinic m2 Pang, C. C. Y., see Wang, Y.-X., 112, 263 -induced antinociception, role of neuro- receptors, cenebellar granule cells tensin, peniaqueductal gray (rats), Pang, K. S., see Polhuijs, M., 1406 (rats), 433 580 Pang, K. S., see St-Pierre, M. V., 1429, 1437 Pessayre, D., see Benson, A., 366 intestinal mobility and nociception, Phe- Pappano, A. J., see Shinayama, T., 641 Petersen, K.-U., see Spnakties, G., 273 Leu-Phe-Gin-Pro-Arg-Phe-NH2 Parasympathetic nervous system, mecha- nism of bnadycandia, anticholinest- pH, gastric mucosal gel thickness, surface amide analogs (rats), 96 cell viability, effect of onogastnic nic- motivational effects, neunochemical sub- erase neostigmine (cats), 194 otine (rats), 948 strates, mesolimbic dopamine system Panietal cells, inhibition of function, epider- Phaclofen, GABA autoreceptons, cerebral (rats), 53 mal growth factor, TGF-a (rabbits), cortex and spinal cord (rats), 765 naloxone-pnecipitated morphine with- 308 Pham, I., Gonzalez, W., El Amrani, A.-I. K., drawal, respiratory control, sympa- Parker, S. L., see Renfro, J. L., 992 Fourni#{233}-Zaluski, M.-C., Philippe, M., thetic nerve activity (rats), 89 Parkinson’s disease, involvement of brain Laboulandine, I., Rouques, B. P. and receptor regulation (mice), 314 dopamine, behavioral action of MK- Michel, J.-B.: Effects of converting reinforcing effects of heroin, effect of an- 801, 6-hydroxydopamine-lesioned enzyme inhibitor and neutral endo- tagonists, opioid mu/delta/kappa rats, 1001 peptidase inhibitor on blood pressure (rats), 1245 Parlani, M., Conte, B. and Manzini, S.: and renal function in experimental stimulation, induction of feeding, ventral Nonadrenengic, noncholinengic in- hypertension, 1339 stniatum (rats), 1253 hibitory control of the rat external Phe-Leu-Phe-Gin-Pno-Gln-Arg-Phe-NH2 Oshida, J.-I., see Uejima, Y., 516 urethral sphincter: Involvement of amide, analogs, intestinal motility, Otagini, M., see Imai, T., 328 nitric oxide, 713 nociception (rats), 96 Ouabain, hepatobiliary excretory function, Parvini, S., Hamann, S. R. and Martin, W. Phenacetin, specificity of substrate and in- chronic physical activity (rats), 321 R.: Pharmacologic characteristics of hibiton probes, cytochromes P450 Overhisen, R. W., see Major, T. C., 187 a medullary hyperalgesic center, 286 Owen, M. P.: Functional characterization of Pastennak, G. W., see Negus, S. S., 1245 1A1 and 1A2 (humans), 401 alpha adrenoceptons on rabbit intra- Pastennak, G. W., see Pick, C. G., 166 Phencyclidine renal arteries in vitro, 807 Patch clamp drugs of abuse and cholinergic agents, Owen, M. P.: Similarities and differences in barbiturate anesthetics, depression of delayed matching-to-sample re- the postjunctional role for neunopep- nesting K conductance, myocardium sponding (monkeys), 120 tide Y in sympathetic vasomoton con- (frog), 358 metabolite covalent binding, dose- and tro! of large vs. small arteries of nab- GABAA receptor-channel complex, char- time-dependent changes, role of bit renal and ear vasculatune, 887 actenization, brain (rats), 985 CYP2D1 (rats), 1261 Owens, S. M., Gunnell, M., Laurenzana, E. Paul, I. A., see Nowak, G., 1380 Phenobarbital M. and Valentine, J. L.: Dose- and Penbutolol, central 5-HT1A and 5-HT1B au- barbiturate anesthetics, depression of time-dependent changes in phency- tonecepton, blocking properties, pen- nesting K conductance, myocardium clidine metabolite covalent binding butolol (rats), 707 (frog), 358 in rats and the possible role of Pendley, C. E., Fitzpatrick, L. R., Ewing, R. genetic obesity and, hepatic conjugation CYP2D1, 1261 W., Molino, B. F. and Martin, G. E.: pathways (rats), 1333 Oxazepam, formation and metabolism, non- The gastnin/cholecystokinin-B re- Phenyl-2-aminoethyl sulfide, methylated diazepam and temazepam, liven ceptor antagonist L-365,260 reduces derivatives, oral antihypertensive ac- (mice), 1429, 1437 basal acid secretion and prevents gas- tivity (rats), 1113 Oxidants, -induced cell death, extracellulan trointestinal damage induced by as- Phenylephrine acidosis, renal proximal tubules (rab- pirin, ethanol and cysteamine in the sensitization of GABA-induced depres- bits), 1355 nat, 1348 sions, cenebellar Purkinje neurons, Oxygen Pentobarbital beta adrenergic mechanisms (rats), consumption, effects of MCI-154, coro- barbiturate anesthetics, depression of 426 nary artery stenosis (dogs), 819 nesting K conductance, myocardium vasoconstnictor activity in mesentenic oxidative stress and thiol modification, (frog), 358 vasculature, quinapnil (rats), 187 chronic administration, halopenidol dependence, behavioral effects, sedative 2-Phenylethoxy-9-methyladenine, A2 aden- (rats), 1137 drugs (baboons), 47 osine receptor discrimination, aorta Oxygen free radicals drugs of abuse and cholinengic agents, and coronary vessels (guinea pigs), adrenochnome reaction, metabolism of cy- delayed matching-to-sample re- 248 closponine A and FK-506, liver mi- sponding (monkeys), 120 Phenylethylamines, endothelium- and beta- crosomes (rats, humans), 1047 intracenebroventnicular administration, 2 adrenoceptor-independent relaxa- differential actions of cisplatin, inner antagonism, morphine-induced an- tion, aorta (rats), 1096 medullary collecting ducts, renal tinociception (mice), 1361 Phenyl(imino)imidazolidine, octopami- proximal tubule (rabbits), 1421 Peptides, somatostatin receptors in nucleus nergic agonists, selectivity, octopa- 1993 Index 1561

mine receptor subtypes (fireflies, of Ca mobilization, isoflurane, vas- nists, AlO dopamine neurons (rats), honnwonms), 509 culan smooth muscle cells, 74 963 IV-Phenylisopropyladenosine, blood levels, Platelets Preconditioning, ATP-sensitive potassium correlation with cardiac responses block of aggregation by 2-aminochno- channel blocker, glibenclamide, is- (guinea pigs), 543 mones, inhibition of cAMP-depend- chemic heart (rats), 559 Philippe, M., see Pham, I., 1339 ent phosphodiesterase (humans), 457 Price, W. A., Jr., see Wong, P. C., 1088 Phosphodiesterase pulmonary thromboembolism-induced a!- Pnisco, S., Cagnotto, A., Talone, D., De cAMP-dependent, block ofplatelet aggre- terations, nitric oxide release, cincu- Blasi, A., Mennini, T. and Esposito, gation, 2-aminochnomones (hu- lating neutrophi!s (rats), 1369 E.: Tertatolol, a new fl-blocker, is a mans), 457 Polhuijs, M., Gasinska, I., Cherry, W. F., serotonin (5-hydroxytryptamine1) effects of adenosine agonists, ventilation Mulden, G. J. and Pang, K. S.: Ster- receptor antagonist in rat brain, 739 (monkeys), 971 eose!ectivity in glutathione conjuga- Procainamide ethobromide, hepatobiliary indolidan- and rolipram-sensitive, cardiac tion and amidase-catalyzed hydroly- excretory function, chronic physical microsomal fractions (dogs, hu- sis of the 2-bromoisovalerylurea activity (rats), 321 mans), 1142 enantiomens in the single-pass per- Progesterone, mifepnistone and, responses to oxytocin, circular myometnium isozymes, functional role, airway smooth fused rat liver, 1406 (rats), 1205 muscle (humans), 1213 Pollock, S. H., Reichbaum, M. I., Colbert, type III, chimenic molecule, inotropic and J. C., Husain, P. A., Holbrook, J. M., Propidium iodide, gastric mucosal gel thick- ness, surface cell viability and pH, beta blocking effects (dogs), 1105 Ogonowski, A. A., Khlief, J. S. and effect of onogastnic nicotine (rats), Phospholipase A2, induction of tolerance to May, S. W.: The oral antihyperten- 948 crotoxin (mice), 41 sive activity of the methylated deny- Propranolo! Phospholipase C atives of phenyl-2-aminoethyl sul- nicotinic antinociception, adrenergic, se- block of platelet aggregation by 2-ami- fide,1113 rotonergic and cholinergic compo- nochnomones, inhibition of cAMP- Polosa, C., see Backman, S. B., 194 dependent phosphodiesterase (hu- nents (rats), 777 Polyamines plasma concentration, fl-b!ockade, dosing mans), 457 mechanism of putrescine transport, pul- rate-dependent relationship (hu- stimulated signal transduction, throm- monary artery endothelial cells (hu- mans), 681 boxane A2, vascular smooth muscle man), 60 (rats), 447 prejunctional beta adrenoceptors, sympa- modulatory sites of NMDA receptors, thetic neurotnansmission, mesentery Photoaffinity labeling, leukotniene genera- prevention of glutamate cytotoxicity, tion and metabolism, inhibition of (rats), 657 ifenprodil (rats), 1017 MK-0591 biosynthesis (dogs), 416 4-Propyl-9-hydnoxynaphthoxazine, modifi- Pompon, D., see Benson, A., 366 Photoneceptors, nod, block of cyclic GMP- cation of behavioral effects, dopa- Pontecorvo, M. J., see Clissold, D. B., 876 activated current, pimozide (frog), mine antagonists (monkeys), 1039 Pontecorvo, M. J., see Karbon, E. W., 866 626 Prostaglandin, differential regulation of Poon, C. I., see Wang, Y.-X., 112 synthesis, angiotensin peptides, aor- Physostigmine Ponreca, F., see Horan, P. J., 896, 1446 tic smooth muscle cells (pigs), 664 agonist site, nicotinic acetylcholine necep- Portoghese, P. S., see Miyamoto, Y., 1325 tons, hippocampal neurons (rats), Proton, permeation, gastric mucosal gel Pontoghese, P. S., see Negus, S. S., 1245 1474 thickness, effect of orogastnic nic- Potassium otine (rats), 948 drugs of abuse and cholinengic agents, conductance, depression with barbiturate Proximal tubules delayed matching-to-sample ne- anesthetics, myocardium (frog), 358 inner medullary collecting duct cells and, sponding (monkeys), 120 differential actions of cisplatin, inner differential actions, cisplatin (nab- Pichoff, B. E., Uyehara, C. F. T. and Nak- medullany collecting ducts, renal bits), 1421 amuna, K. T.: Effect of calcium ago- proximal tubule (rabbits), 1421 renal, cell death, extracellular acidosis nists, BAY K 8644 and CGP 28392, Potassium channel (rabbits), 1355 on guinea pig airway smooth muscle action potential durations, minoxidil sul- Putrescine, mechanism of transport, pul- function during development, 524 fate-induced shortening, ventricular monany artery endothelial cells (hu- Pick, C. G., Nejat, R. J. and Pasternak, G. man), 60 W.: Independent expression of two myocytes (guinea pigs), 1527 pharmacologically distinct supraspi- Al-selective agonist RG14202 (pigs), 699 ATP-sensitive Quattrochi, L. C., see Tassaneeyakul, W., nal mu analgesic systems in geneti- 401 cally different mouse strains, 166 blocker glibenclamide, no abolishment of preconditioning (rats), 559 Quinapni!, vasoconstnictor activity, mesen- Piedimonte, G., Hoffman, J. I. E., Husseini, tenic vasculatune (rats), 187 W. K., Bertrand, C., Snider, R. M., cardioprotection with zofenopnil, myo- candial ischemia (rats), 609 Qumnuclidinyl benzi!ate, mu opiate receptor, Desai, M. C. and Nadel, J. A.: Neu- up-regulation by morphine, down- nogenic vasodilation in the rat nasal relaxation of coronary arteries, calci- tonin gene-related peptide (pigs), 490 regulation by naloxone in neuno- mucosa involves neunokinin1 tachy- blastoma cells (humans), 254 kinin receptors, 36 blocker glybunide, natniuretic properties (rats), 933 Pierce, G. N., Cole, W. C., Liu, K., Massaeli, Radioimmunoimaging, radiolabeled defer- delayed rectifier, inhibition by 2,3-buts- H., Maddafond, T. G., Chen, Y. J., oxamine-biotin derivatives, plasma nedione monoxime, Xenopus oocytes, McPherson, C. D., Jam, S. and Son- stability and pharmacokinetics, 408 tag, D.: Modulation of cardiac per- 1011 Raiteni, M., see Bonanno, G., 765 differential effects of endothelin, gastric formance by amilonide and several Ram, P. A., see Shapiro, B. H., 979 selected derivatives of amilonide, longitudinal and circular smooth Rampe, D., Anderson, B., Rapien-Pryon, V., 1280 muscle (rats), 1413 Li, T. and Dage, R. C.: Comparison Pimozide, block of cyclic GMP-activated opener lemakalim, systemic, coronary and of the in vitro and in vivo cardiovas- current, rod photoreceptors (frog), regional vascular dynamics (dogs), cular effects of two structurally dis- 626 1026 tinct Ca channel activators, BAY Pirenzepine, nicotinic antinociception, ad- Potts, A. A., see Martin, P. L., 201 K 8644 and FPL 64176, 1125 nenengic, senotonergic and cholinengic Poulsen, H. E., see Boesgaand, 5., 1239 Rapien-Pryor, V., see Rampe, D., 1125 components (rats), 777 Prazosin, nicotinic antinociception, adre- Ravindranath, V., see Shivakuman, B. R., Plasma, stability and pharmacokinetics, na- nengic, serotonergic and cholinengic 1137 diolabeled deferoxamine-biotin de- components (rats), 777 Raynon, K., Lucki, I. and Reisine, T.: rivatives, 408 Preclamo!, electrophysiological effects, au- Somatostatin, receptors in the nu- Platelet-derived growth factor, attenuation toneceptor-selective dopamine ago- cleus accumbens selectively mediate 1562 Index Vol. 265

the stimulatory effect of somato- stress, peniventniculan hypophysial do- Reichart, B., see Schwinger, R. H. G., 346 ststin on locomotor activity in rats, paminergic neurons (rats), 303 Reichbaum, M. I., see Pollock, S. H., 1113 67 5-HT3 and 5-HT4, antagonist FK1052, Reinhardt-Maelicke, S., see Pereira, E. F. Razdan, R. K., see Compton, D. R., 218 pharmacological characterization R., 1474 Receptors (rats, guinea pigs), 752 Reisine, T., see Raynor, K., 67 M-t5 complex, antinociceptive profile, bi- kainate, activation of nociceptive reflexes Renfro, J. L., Brown, M. A., Parker, S. L. phalin (mice), 1446 (rats), 927 and Hightower, L. E.: Relationship adenosine A1 N-methy!-D-aspartate of thermal and chemical tolerance to antagonist N-0840, pharmacological adaptive changes, imipramine and 1- tnansepithelial transport by cultured characterization, 227 aminocyclopropanecarboxylic acid flounder rena! epithelium, 992 N-0861 and its enantiomers (guinea treatment (mice), 1380 Renin-angiotensin system, vasoconstnictor pigs), 201 prevention of glutamate cytotoxicity by activity in mesentenic vasculature, adenosine A2, discrimination in aorta and ifenprodli, cortical neurons (rats), quinapnil (rats), 187 coronary vessels, 2-pheny!ethoxy-9- 1017 Respiration, control of sympathetic nerve methyladenine (guinea pigs), 248 muscaninic, mechanism of bradycandia, activity, naloxone-precipitated mor- angiotensin anticholinestenase neostigmine (cats), phine withdrawal (rats), 89 neuromodulatory effects, vas deferens 194 RG14202, Al-selective adenosine agonist (rabbits), 601 muscaninic M2 (pigs), 699 prostaglandin synthesis, aortic smooth carbachol-induced sodium current, yen- Rice, K. C., see Compton, D. R., 218 muscle (pigs), 664 tnicular myocytes (guinea pigs), 641 Riska, P., see Farina, P. R., 483 angiotensin II, antagonist SR 47436, short-term desensitization, cerebellar Riva, M. A., see Longone, P., 441 pharmacological characterization granule cells (rats), 433 Rivera, L. M., see Merkel, L. A., 699 (rats, dogs, monkeys), 826 neurokinin, tachykinins and atnopine-ne- RNA, mammalian and amphibian, chimenic benzodiazepine, ligands, hepatic enceph- sistant motility, colon (guinea pigs), kainate/NMDA receptors, expres- alopathy (rats), 565 1224 sion in Xenopus oocytes (rats), 910 binding and in vivo activities, cannabi- neunokinin, tachykinin, neurogenic vaso- RNA, messenger, muscarinic m2, carbachol, noid structure-activity relationships dilation, nasal mucosa (rats), 36 cenebellar granule cells (rats), 441 (rats), 218 neuromuscular junction, buffering hy- Ro 41-1049, monoamine oxidase-A inhibi- chimenic kainate/NMDA, expression in pothesis, speed of action of muscle tons, dopamine metabolism, caudatus Xenopus oocytes, mammalian and nelaxants, 1181 (rats), 103 amphibian RNA (rats), 910 neuropeptide Y, constriction in femonal Roache, J. D., see Gniffiths, R. R., 1163 cholinengic, microdialysis, l,2,3,4-tetnah- artery rings, benextnamine protec- Robertson, D., see Tseng, C.-J., 1511 ydroaminoacnidine (rats), 759 tion studies (rats), 172 Robertson, L. W., see Chaudhary, I. P., 1333 dopamine, autoreceptor-selective dopa- nicotinic acetylcholine Roccon, A., see Cazaubon, C., 826 mine agonists, electrophysiological agonist site, hippocampal neurons Rocuronium, speed of action, neuromuscu- effects (rats), 963 (rats), 1474 lan junction binding vs. buffering hy- dopamine D1 and D2 diversity, hippocampal neurons (rats), pothesis, 1181 agonist potency and efficacy, MPTP- 1455 Rod, photoreceptors, block of cyclic GMP- induced hemipankinsonian monkeys, ganglia-type, neuroblastoma clone line activated current, pimozide (frog), 1387 (humans), 294 626 motivational effects of opioids, neuro- NPC 16377, binding, neurochemical and Rodeheaver, D. P. and Schnellmann, R. G.: chemical substrates (rats), 53 neuroendocnine profile (rats, mice), Extnacellular acidosis ameliorates occupation, antipsychotic drugs (rats), 866 metabolic-inhibitor-induced and p0- 498 octopamine, subtypes, octopaminengic ag- tentiates oxidant-induced cell death GABA, autoreceptors, cerebral cortex and onists (fireflies, hornwonms), 509 in renal proximal tubules, 1355 spinal cord (rats), 765 opiate mu, down-regulation by morphine, Rolipram GABAA up-regulation by naloxone in neuro- effects of adenosine agonists, ventilation influence of estrus cycle, neunostenoid blastoma cells (humans), 254 (monkeys), 971 potency (rats), 1374 opioid, regulation (mice), 314 -sensitive cyclic nucleotide phosphodies- neunochemical actions, inhalationa! an- opioid delta, agonist and antagonist pro- terases, cardiac microsomal fractions esthetics (mice), 1392 files, substituted deltorphins (mice), (dogs, humans), 1142 GABAA-channel complex, characteriza- 896 Romeo, E., see Auta, J., 649 tion, brain (rats), 985 opioid delta-2, acute dependence on mor- Roppolo, J. R., see Yoshiyama, M., 844 GABAB, muscarinic m2 receptors, cere- phine (mice), 1325 bellan granule cells (rats), 433 opioid mu Roques, B. P., see Kalso, E. A., 551 gastnmn/cho!ecystokmnin-B, antagonist L- changes in renal function (rats), 134 Roques, B. P., see Pham, I., 1339 365,260, prevention of gastrointes- cross-tolerance with alpha-2 adre- Rosebrough, S. F.: Plasma stability and tinal damage (rats), 1348 noceptors, spinal cord (rats), 551 phanmacokinetics of nadiolabeled de- 5-HT supraspinal analgesic systems, geneti- fenoxamine-biotin derivatives, 408 agonists, neuronal circuits in discrimi- cally different mouse strains, 166 Rosenzweig-Lipson, S. and Bergman, J.: native stimulus effects (rats), 572 supraspinal antinociception, N-acetyl Modification ofthe behavioral effects serotonin-facilitated dopamine release 3-endorphin-(1--31) and substance P of the selective dopamine D2 agonist (rats), 373 (mice), 835 (+)-4-pnopyl-9-hydroxynaphthoxa- 5-HT1A opioid mu/delta/kappa, effect of antago- zine by dopamine antagonists in effect of spiperone, dorsal raphe and nists, reinforcing effects of heroin monkeys, 1039 hippocampus (rats), 7 (rats), 1245 Rotenone, cell death and extnacellular aci- pertussis and cholera toxins, dorsal puninergic P2 dosis, renal proximal tubules (rab- raphe and hippocampus (rats), 16 human breast tumor cells, 1499 bits), 1355 5-HT1A and 5-HT1B, modulation, spinal pharmacological characterization, ne- Rousseau, E., see Lugnien, C., 1142 nociceptive transmission (mice), 378 novascular system (rats), 334 Rubidium-86, cromakalim-induced efflux, 5-HT2 somatostatin, locomotor activity, nucleus inhibition by 8-(diethy!amino)-octy!- occupation, antipsychotic drugs (rats), accumbens (rats), 67 3,4,5-tnimethoxybenzoate, aorta (rats), 498 Reeves, M. L., see Torphy, T. J., 1213 1399 pharmacology, species differences Reflex, nociceptive, activation, peripheral Rutter, J. J. and Auerbach, S. B.: Acute (rats), 1272 kainate receptors (rats), 927 uptake inhibition increases extracel- 1993 Index 1563

lular serotonin in the rat forebrain, H., Reichart, B. and Endmann, E.: Shivakumar, B. R. and Ravindranath, V.: 1319 Cardiac inotnopic as well as coronary Oxidative stress and thiol modifica- and pulmonary actions of epinine in tion induced by chronic administra- Sadeghi, H. M. and Eikenbung, D. C.: Is human isolated tissues, 346 tion of halopenido!, 1137 sympathetic neunotnansmission in Scopolamine, drugs of abuse and cholinergic Shock, bacterial !ipopo!ysaccharide, induc- the rat mesentery modulated by pre- agents, delayed matching-to-sample tion of nitric oxide synthase, inhibi- junctional beta adrenoceptors?, 657 responding (monkeys), 120 tion by nifedipine (mice), 674 Sad!, V., see Tagani, P., 416 S-312-d, ischemic amino acid release and Shryock, J., see Dennis, D. M., 543 Salazan, L. A., see Cruz, S. L., 1519 neunonal injury, stroke-prone SHR Signal transduction Salbutamol, prejunctional beta adnenocep- rats, 463 inhibition of paniets! cell function, epi- tons, sympathetic neunotransmission, Secretin, somatostatin and, modulators of dermal growth factor, TGF-a (nab- mesentery (rats), 657 electrolyte transport, gallbladder ep- bits), 308 Salt, -induced hypertension, prevention by ithelium (guinea pigs), 273 thromboxane A2, vascular smooth muscle losartan, reduced renal mass rats, Seizure, threshold, excitatory amino acids, (rats), 447 1131 antiepileptic drugs and chemoconvul- Sill, J. C., Eskuni, S., Nelson, R., Tarara, J. S#{225}nchez-Bl#{225}zquez,P. and Garz#{243}n,J.: N- sants (mice), 1063 acetyl $-endorphin-(1-31) and sub- and Van Dyke, R. A.: The volatile Senda, T., see Matsuno, K., 851 anesthetic isoflunane attenuates Ca stance P regulate the supraspinal an- Serik, C. M., see Lynch, J. J., Jr., 720 mobilizaton in cultured vascular tinociception mediated by mu opioid Serotonin and alpha-2 adrenoceptors but not by smooth muscle cells, 74 extracellular, acute uptake inhibition, delta opioid receptors in the mouse, Simon, R. P., Chen, J. and Graham, S. H.: forebrain (rats), 1319 GM1 treatment of focal ischemia: A 835 -facilitated dopamine release, pharmaco- Sanguinetti, M. C., see Lynch, J. J., Jr., 720 dose-response and microdialysis logical characterization (rats), 373 Sarcoplasmic reticulum, Ca ATPase, in- study, 24 halopenidol-induced catalepsy (rats), 207 hibition of relaxation, nitroglycerin SKF-38393, involvement of brain dopa- 5-HT3 receptor-mediated ion current, and atnial natniunetic factor (rabbits), mine, behavioral action of MK-80l, tnich!onoethano!potentiation, nodose 1187 6-hydnoxydopamine-lesioned rats, ganglion neurons (rats), 771 Sargent, C. A., see Grover, G. J., 559 1001 microinjection into nucleus naphe obscu- Sargent, C. A., Sleph, P. G., Dzwonczyk, S., Skolnick, P., see Harris, B., 1392 rus, increased intragastnic pressure, Smith, M. A., Nonmandin, D., Anton- Skolnick, P., see Nowak, G., 1380 vagal mediation (rats), 468 accio, M. J. and Grover, G. J.: Car- Slaninova, J., see Honan, P. J., 1446 NPC 16377 receptor binding, neunochem- dioprotection in ischemic rat hearts Sleph, P. G., see Grover, G. J., 559 ical and neuroendocnine profile (rats, with the SH-contsining angiotensin- Sleph, P. G., see Sargent, C. A., 609 mice), 866 converting enzyme inhibitor zofeno- Sloan, J. W., Martin, W. R. and Wala, E.: short-term effects, MDMA metabolites pnil: Possible involvement of the Effect of the chronic dose of diaze- (rats), 813 adenosine tniphosphate-sensitive po- pam on the intensity and character- vasoconstnicton activity in mesentenic tassium channel, 609 istics of the precipitated abstinence vasculatune, quinapnil (rats), 187 Sasa, M., see Tamuna, Y., 1017 syndrome in the dog, 1152 Seven, P. 5., see Calden, J. A., 1175 Sathinakul, K., Suzuki, H., Yasuda, K., Han- Smallwood, V. V., see Va!eyev, A. Y., 985 Seven, P. 5., see Garcha, R. S., 860 ano, M., Tagaya, 0., Hone, T. and Smith, D. J., see Urban, M. 0., 580 Seyama, I., see Yakehiro, M., 1328 Sugiyama, Y.: Kinetic analysis of Smith, J. E., see Goeders, N. E., 592 Shaffen, J. E., Grizzle, M. K., Anderson, D. hepatobiliany transport of organic Smith, M. A., see Sargent, C. A., 609 K. and Wheeler, T. N.: The inotnopic anions in Eisai hypenbilirubinemic Smith, M. P., see Clark, M. A., 933 and beta blocking effects of a chi- mutant rats, 1301 Smith, R. D., see Wong, P. C., 1088 menic molecule that putatively inhib- Sato, Y., see Tamuna, Y., 1017 Smits, G. J., see Menkel, L. A., 699 its both type III phosphodiestenase Sawaki, S., see Furukawa, Y., 801 Snider, R. M., see Piedimonte, G., 36 and beta adrenoceptons in anesthe- Schachten, M., see Calder, J. A., 1175 Sodium, natniunetic properties, glybunide tized dogs, 1105 Schindler, C. W., see Yasar, S., 1 (rats), 933 Schizophrenia Shapiro, B. H., Pamponi, N. A., Ram, P. A. and Waxman, D. J.: Irreversible Sodium channel, structure-activity relation- antipsychotic drugs, dopamine D1 and D2, ship, D-ning derivatives, grayano- 5-HT2 receptor occupation (rats), 498 suppression of growth honmone-de- pendent cytochrome P450 2C11 in toxin (squid), 1328 electrophysiological effects, autorecepton- Sodium current, canbachol-induced, ventnic- selective dopamine agonists, AlO do- adult rats neonatally treated with monosodium glutamate, 979 ular myocytes, guanine nucleotides pamine neurons (rats), 963 (guinea pigs), 641 NPC 16377 receptor binding, neurochem- Sharp, T., see Hjorth, S., 707 Sodium fluxes, modulators of electrolyte ical and neunoendocrine profile (rats, Shaw, L., see Kurth, C. D., 587 transport, secretin and somatostatin, mice), 866 Shen, Y.-T. and Vatner, S. F.: Effects of a gallbladder epithelium (guinea pigs), Schmid, B., see Schwinger, R. H. G., 346 KATP channel opener, lemakalim, on 273 Schmidt, U., see Schwinger, R. H. G., 346 systemic, coronary and regional vas- Sodium nitroprusside, endothelium-de- Schnellmann, R. G., see Rodeheaver, D. P., cular dynamics in conscious dogs: pendent relaxation of aorta, L- and 1355 Comparison with nifedipine, adeno- D-enantiomers, NGnitnoarginine Schnattenho!z, A., see Pereina, E. F. R., 1474 sine, nitroglycerin, and acety!cho!ine, Schneiben, R. and de Vry, J.: Studies on the 1026 (rats), 112 neuronal circuits involved in the dis- Sheng, J., see Domino, E. F., 1387 Sodium-potassium adenosine tniphospha- criminative stimulus effects of 5-hy- Shippenbeng, T. S., Bals-Kubik, R. and tsse, differential actions of cisplatin, droxytryptamine receptor agonists in Henz, A.: Examination of the neuno- inner medullary collecting ducts, the nat,572 chemical substrates mediating the renal proximal tubule (rabbits), 1421 Schulz, C., see Schwingen, R. H. G., 346 motivational effects of opioids: Role Sokol, P. P., Longenecken, K. L., Kache!, D. Schwam, E. M., see Gniffiths, R. R., 1163 of the mesolimbic dopamine system L. and Martin, W. J., II: Mechanism Schwartz, J. B., Troconiz, I. F., Verotta, D., and D- 1 vs. D-2 dopamine receptors, of putrescine transport in human pul- Liu, S. and Capili, H.: Aging effects 53 monary artery endothelial cells, 60 on stereoselective pharmacokinetics Shinayama, T., Matsumoto, K. and Pap- Somatostatin, secretin and, modulators of and pharmacodynamics of venapamil, pano, A. J.: Carbachol-induced so- electrolyte transport, gallbladder ep- 690 dium current in guinea pig ventricu- ithelium (guinea pigs), 273 Schwinger, R. H. G., B#{246}hm,M., Schulz, C., lar myocytes is not regulated by Someya, K., see Takahashi, H., 681 Schmidt, U., Schmid, B., Dienemann, guanine nucleotides, 641 Sontag, D., see Pierce, G. N., 1280 1564 Index Vol. 265

Species differences, pharmacology of 5-HT2 chemic amino acid release and neu- Ohina, M. and Someya, K.: Dosing receptor (rats), 1272 ronal injury, 463 rate-dependent relationship between Sphincter, urethral, involvement of nitric Stupienski, R. F., see Lynch, J. J., Jr., 720 propranolol plasma concentration oxide, inhibitory control (rats), 713 Suberyldicholine, diversity of nicotinic ace- and 3-blockade, 681 Spinal cord tylcholine receptors, hippocampal Takanashi, M., see Kohi, M., 1292 activation of nociceptive reflexes, peniph- neurons (rats),1455 Takaoni, S., see Tamuna, Y., 1017 era! kainate receptors (rats), 927 Substance P Takayama, S., see Funukawa, Y., 801 cerebral cortex and, GABA autoneceptons, N-acetyl fl-endorphin-(l-31) and, supna- Takemoni, A. E., see Miyamoto, Y., 1325 receptor subtypes (rats), 765 spinal antinociception, mu opioid Takemoni, A. E., see Negus, S. S., 1245 cross-tolerance, mu opioid and alpha-2 and alpha-2 adrenoceptons (mice), Tallant, E. A., see Jaiswal, N., 664 adrenengic receptors (rats), 551 835 Talone, D., see Pnisco, S., 739 modulation of kainic acid-induced activ- amino terminus, modulation of kainic Tamuna, Y., Sato, Y., Yokota, T., Akaike, ity, amino terminus of substance P acid-induced activity, spinal cord A., Sasa, M. and Takaoni, S.: Ifenpro- (mice), 159 (mice), 159 dil prevents glutamate cytotoxicity Spine, nociceptive transmission, modula- neurogenic vasodilation, neurokinin1 ta- via polyamine modulatory sites of N- tion, 5-HT1A and 5-HTIB receptor chykinin receptors, nasal mucosa methyl-D-aspartate receptors in cul- (rats), 36 subtypes (mice), 378 tuned cortical neurons, 1017 Substrate, inhibitor probes and, cyto- Spipenone, differential properties of 5-HT1A Tarara, J., see Sill, J. C., 74 receptors, dorsal raphe and hippo- chromes P450 1A1 and 1A2 (hu- Tassaneeyakul, W., Binkett, D. J., Venonese, mans), 401 campus (rats), 7 M. E., McManus, M. E., Tukey, R. Sugiyama, Y., see Sathinakul, K., 1301 Splenocytes, gallium arsenide-induced H., Quattrochi, L. C., Gelboin, H. V. Sulfate, thermal and chemical tolerance, suppression, antibody-forming cell and Miners, J. 0.: Specificity of sub- transepithelial transport, renal epi- response, reversal by vehicle super- strate and inhibitor probes for hu- thelium (flounder), 992 natants (mice), 144, 150 man cytochnomes P450 lAl and 1A2, Sulfhydryl groups, substituted deltorphins, Spnakties, G., Macherey, H. J. and Petersen, 401 opioid delta receptor multiplicity Taurocholate, chronic physical activity, K-U.: Secretin and somatostatin as (mice), 896 hepatobiliary excretory function modulators of electrolyte transport in Sulfonylureas, natniunetic properties, gly- guinea pig gallbladder epithelium, (rats), 321 bunide (rats), 933 273 Taylor, D. G., Jr., see Major, T. C., 187 Sullivan, A. F., see Kalso, E. A., 551 T cells, inhibition ofpnolifenation by gallium SR 47436, pharmacological characterization Sun, X., see Larson, A. A., 159 arsenide, altered CD25 expression (rats, dogs, monkeys), 826 Sutton, S. C., see Lecluyse, E. L., 955 (mice), 178 Snima!, R. C., see Dikshit, M., 1369 Suzuki, H., see Sathinakul, K., 1301 Temazepam, nondiazepam and, formation ST-91, alpha-2 adrenoceptor-mediated an- Sweeney, K. R., see Statkevich, P., 1118 and metabolism of oxazepam, liven tinociception, cholinergic interaction Sweetsna-Grass diffusion cells, permeabil- (mice), 1429, 1437 (sheep), 536 ity and morphology, colonic mucosa, Tertatolo!, 5-HT1A receptor antagonist, Statkevich, P., Fournien, D. J. and Sweeney, long-chain acylcarnitines (rats), 955 brain (rats), 739 K. R.: Characterization of metho- Sykes, A. M., see Martin, P. L., 201 Tessel, R. E., Miller, D. W., Misse, G. A., trexate elimination and interaction Sympathetic nervous system Dong, X. and Doughty, M. B.: Char- with indomethacin and flunbiprofen brain stem mechanisms, effects of nic- actenization of vascular postsynaptic in the isolated perfused rat kidney, otine, cardiovascular control (rats), neuropeptide Y receptor function and 1118 1511 regulation. 1. NPY-induced constnic- Stein, R. B., see Lynch, J. J., Jr., 720 constriction of cerebral arterioles, cocaine tion in isolated rat femonal artery Steppuhn, K. G. and Tunski, L.: Modulation and its metabolites (piglets), 587 rings is mediated by both Y1 and Y2 of the seizure threshold of excitatory functional characterization, alpha adne- receptors: Evidence from benextra- amino acids in mice by antiepileptic noceptons, intnarenal arteries (nab- mine protection studies, 172 drugs and chemoconvulsants, 1063 bits), 807 Testosterone 2a-hydroxy!ase, growth hor- functional integrity, pressor and tachy- Stomach, anti-inflammatory-histamine H2 mone-dependent cytochrome P450 antagonist drug complex, gastric ero- cardiac effects, diphenyleneiodonium 2Ci 1, irreversible suppression, mon- sions (rats), 328 (rats), 263 osodium glutamate (rats), 979 Stonnetta, R. L., see Baraban, S. C., 89 respiratory control, naloxone-precipi- l,2,3,4-Tetrahydno-9-aminoacnidine, micro- tated morphine withdrawal (rats), 89 St.-Pienne, M. V. and Pang, K. S.: Kinetics dialysis, extracellular concentration of sequential metabolism. II. Forma- Synaptosomes, GABA autoreceptors, cere- of acetylcholine, striatum (rats), 759 bra! cortex and spinal cord (rats), 765 tion and metabolism of nondiazepam Tetrodotoxin, monoamine oxidase-A inhib- Szab#{244},C., Mitchell, J. A., Gross, S. S., Thie- and oxazepam from diazepam in the itons, dopamine metabolism, cauda- mermann, C. and Vane, J. R.: Nife- perfused munine liver, 1437 tus (rats),103 dipine inhibits the induction of nitric St-Pierre, M. V. and Pang, K. S.: Kinetics Thapsigargin, attenuation of Ca mobili- oxide synthase by bacterial lipopoly- of sequential metabolism. I. Forma- zation, isoflunane, vascular smooth sacchanide, 674 tion and metabolism of oxazepam muscle cells, 74 Szelenyi, I.,see Yasar, 5., 1 from nordiazepam and temazepam in Thermotolenance, chemical tolerance and, the perfused munine liver, 1429 Tachycardia, diphenyleneiodonium, func- transepithelial transport, renal epi- Stneptsvidin, radiolabeled defenoxamine- tional integrity, CNS and sympa- thelium (flounder), 992 biotin derivatives, plasma stability thetic nervous system (rats), 263 Thiazide, diuretics, acute vascular effects, and phanmacokinetics, 408 Tachykinins, neflexly evoked atnopine-re- ion channel involvement (guinea Streptococcus pneumoniae, inhibition of sistant motility, colon (guinea pigs), pigs), 1175 bacterial growth, gallium arsenide- 1224 Thiemermann, C., see Szab#{243},C., 674 exposed mice, arsenic in sena, 795 Tagani, P., Becker, A., Bnideau, C., Fnenette, Thiol, modification, oxidative stress, Stniatum, extracellular concentration of R., Sad!, V., Thomas, E., Vickers, P., chronic haloperidol administration acetylcholine, microdialysis, 1,2,3,4- and Ford-Hutchinson, A.: Leuko- (rats), 1137 tetnahydroaminoacnidine (rats), 759 tniene generation and metabolism in Thiopentsl, barbiturate anesthetics, depres- Strobel, H. W., see Ahmed, S. S., 1047 dogs: Inhibition of biosynthesis by sion of resting K conductance, myo- Stroke MK-0591, 416 cardium (frog), 358 GM1 treatment of focal ischemia (rats), Tagaya, 0., see Sathirakul, K., 1301 Thomas, E., see Tagani, P., 416 24 Taira, N., see Kageyama, M., 490 Thonndike, E. B., see Yasar, 5., 1 -prone SHR rats, effects of S-3l2-d, is- Takahashi, H., Ogats, H., Kashiwada, K., Thromboembolism, pulmonary, alterations 1993 Index 1565

in nitric oxide release, circulating wabata, H., Kato, Y. and Fujii, K.: 5- role ofnitnic oxide, cerebral artery (pig), neutrophils (rats), 1369 Methyl-4H-3,l-benzoxazin-4-one de- 339 Thnomboxane A2, stimulated signal trans- nivatives: Specific inhibitors of hu- Vasopnessin, attenuation of Ca mobiliza- duction, vascular smooth muscle man leukocyte elastase, 516 tion, isoflunane, vascular smooth (rats), 447 UL-FS 49, increased atnial force and de- muscle cells, 74 Thymocytes, subpopulations, morphine-in- creased ventricular force, heart prep- Vasorelaxation, ion channel involvement, duced alterations (mice), 81 arations (dogs), 801 acute vascular effects, thiazide di- Timmenmans, P. B. M. W. M., see Wong, Undem, B. J., see Torphy, T. J., 1213 uretics (guinea pigs), 1175 P. C., 1088 Urban, M. 0. and Smith, D. J.: Role of Vatner, S. F., see Shen, Y.-T., 1026 Timolo!, sensitization of GABA-induced neunotensin in the nucleus naphe Vecuronium, speed of action, neunomuscu- depressions, cerebellar Purkinje neu- magnus in opioid-induced antinoci- lar junction binding vs. buffering hy- rons, beta adrenergic mechanisms ception from the peniaqueductal gray, pothesis, 1181 and ethanol (rats), 426 580 Venkova, K. M., see Mutafova-Yambolieva, Tirapazamine, pharmacokinetics and bio- Urethra, external sphincter, involvement of V. N., 920 reductive metabolism (mice), 938 nitric oxide, inhibitory control (rats), Ventilation, effects of adenosine agonists Tokoro, K., see Nagakuna, Y., 752 713 (monkeys), 971 Tolerance, induction of, crotoxin (mice), 41 Usherwood, P. N. R., see Bnakcley, P. T. H., Ventral stniatum, induction of feeding, Tomoi, M., see Nagakura, Y., 752 910 opioid stimulation (rats), 1253 Tong, C., see Detweilen, D. J., 536 Uyehara, C. F. T., see Pichoff, B. E., 524 Ventral tegmental area, electnophysiologica! Torphy, T. J., Undem, B. J., Cieslinski, L. effects, autoneceptor-selective dopa- Vagus nerve, senotonin microinjection into B., Luttmann, M. A., Reeves, M. L. mine agonists, AlO dopamine neu- nucleus raphe obscurus, increased in- and Hay, D. W. P.: Identification, nons (rats), 963 tragastnic pressure (rats), 468 characterization and functional role Ventricle, decreased force, increased atnial Valentine, J. L., see Owens, S. M., 1261 of phosphodiestenase isozymes in hu- force, UL-FS 49 (dogs), 801 Valeyev, A. Y., Barker, J. L., Cruciani, R. man airway smooth muscle, 1213 Verapamil A., Lange, G. D., Sma!lwood, V. V. Transforming growth factor-a, epidermal action of am!odipine, subcutaneous resist- and Mahan, L. C.: Characterization growth factor and, inhibition of pa- ance arteries (humans), 860 ofthe -y-aminobutynic acidA receptor- nietal cell function (rabbits), 308 stereoselective pharmacokinetics and channel complex composed of a1fl2 Tnichloroethanol, potentiation of 5-HT3 re- pharmacodynamics, aging effects and a1fl3 subunits from rat brain, 985 ceptor-mediated ion current, nodose (humans), 690 Van den Gaag, L. H., see Lynch, J. J., Jr., ganglion neurons (rats), 771 Veronese, M. E., see Tassaneeyaku!, W., 401 720 2, 4, 6-Triethyl-phenyl(imino)imidazolidine, Venotts, D., see Schwartz, J. B., 690 Vandenmeersch, S., see Chansel, D., 1534 2,4,6-tnimethyl-pheny!(imino) Venschoyle, R. D., Dinsdale, D. and Wolf, Van Dyke, R. A., see Sill, J. C., 74 imidazolidine and, octopaminergic C. R.: Inhibition and induction of Vane, J. R., see Szab#{243},C., 674 agonists, octopamine receptor sub- cytochnome P450 isoenzymes in rat Van Rijn, H. J. M., see Bijlsma, J. A., 1267 types (fireflies, hornwonms), 509 lung, 386 Tnifluoperazine, mitochondrial and glyco- Varma, D. R. and Chemtob, S.: Endothe- Vickens, P., see Tagani, P., 416 hum- and beta-2 adrenocepton-inde- lytic dysfunction, lethal injury to he- Vidal, J. C., see Okamoto, M., 41 patocytes (rats), 392 pendent relaxation of rat aorta by Villanreal, J. E., see Crux, S. L., 128, 1519 2,4,5-Tnihydroxyamphetamine, 2,4,5-tnihy- tyramine and certain other phenyl- Viskatis, L. J., see Okamoto, M., 41 droxymethamphetamine and, central ethylamines, 1096 Voltage clamp tryptophan hydroxylase activity Vascular permeability, tissue injury, inhibi- barbiturate anesthetics, depression of (rats), 813 tion of vascular leakage, neurotensin resting K conductance, myocandium Tnoconiz, I. F., see Schwartz, J. B., 690 peptides (rats), 619 (frog), 358 Trullas, R., see Nowak, G., 1380 Vascular resistance, comparison of vasodi- chimenic kainate/NMDA receptors, Tryptamines, species differences in phar- lators, lemakalim (dogs), 1026 expression in Xenopus oocytes, mam- macology, 5-HT2 receptor (rats), Vasculatune malian and amphibian RNA (rats), 1272 mesentenic, vasoconstnictor activity, qui- 910 Tryptophan hydroxylase, central activity, napnil (rats), 187 sympathetic vasomotor control, postjunc- short-term effects, MDMA metabo- Wainscott, D. B., see Nelson, D. L., 1272 tional role, neuropeptide Y (rabbits), lites (rats), 813 Wala, E., see Sloan, J. W., 1152 887 Tseng, C.-J., Appalsamy, M., Robertson, D. Wallace, A. A., see Lynch, J. J., Jr., 720 Vas deferens and Mosqueda-Garcia, R.: Effects of Walton, M. I. and Workman, P.: Phanma- electrically induced contractile responses, nicotine on brain stem mechanisms cokinetics and bioneductive metabo- inhibition of puninengic component, of cardiovascular control, 1511 lism of the novel benzotniazine di-N- atnial natniuretic peptide (guinea Tsuzuki, K., see Im, H. K., 529 oxide hypoxic cell cytotoxin tirapa- pigs), 920 D-Tubocuronium, speed of action, neuro- zamine (WIN 59075; SR 4233; NSC neuromodulatory effects of angiotensin, muscular junction binding vs. buff- 130181) in mice, 938 angiotensin receptors (rabbits), 601 ering hypothesis, 1181 Waltzing syndrome, region-dependent dam- Tukey, R. H., see Tassaneeyaku!, W., 401 Vasoconstniction age to central nervous system, levels Tuntaterdtum, S., see Chaudhary, I. P., 1333 functional characterization, alpha adre- above brain stem, 3,3’-iminodipno- Turski, L., see Steppuhn, K. G., 1063 noceptors, intrarenal arteries (rab- pionitnile (rats), 1492 Tyramine, endothelium- and beta-2 adre- bits), 807 Wang, F. S. and Fujimoto, J. M.: Pentoban- noceptor-independent relaxation, quinapnil, activity in mesentenic vascula- bital administered intracerebroven- aorta (rats), 1096 tune (rats), 187 vascular postsynaptic neunopeptide Y re- tnicularly antagonizes morphine-in- U-50,488H, medullary hyperalgesic center, ceptor function (rats), 172 duced antinociception in mice, 1361 pharmacological characteristics Vasodilation Wang, L., Lucey, M. R., Fras, A. M., Wilson, (rats), 286 antiprolifenative and endothelium-de- E. J. and Del Valle, J.: Epidenmal U-88,779E, block of transient calcium chan- pendent, l,3-dihydro-3-p-chlono- growth factor and transforming nel current, neunoblastoma cells phenyl-7-hydroxy-6-methyl-furo-(3, growth factor-a directly inhibit pan- (mice), 529 4c) pyridine hydrochloride (rats), 30 etsl cell function through a similar Ueda, I., see Imai, T., 328 Al-selective agonist RG14202 (pigs), 699 mechanism, 308 Ueda, M., see Gemba, T., 463 neunogenic Wang, Y.-X., Poon, C. I. and Pang, C. C. Ueeda, M., see Martin, P. L., 248 neurokinin1 tachykinin receptors, nasal Y.: In vitro and ex vivo inhibitory Uejima, Y., Kokubo, M., Oshida, J.-I., Ka- mucosa (rats), 36 effects of L and D-enantiomens of 1566 Index Vol. 265

nitro-anginine on endothelium-de- Wolf, C., see Benson, A., 366 deprenyl for amphetamine-like dis- pendent relaxation of rat aorta, 112 Wolf, C. R., see Verschoyle, R. D., 386 cniminative stimulus effects in rats, 1 Wang, Y.-X. and Pang, C. C. Y.: Functional Wong, G., see Harris, B., 1392 Yasuda, K., see Sathirakul, K., 1301 integrity of the central and sympa- Wong, P. C., Aldrich, P. E., Chiu, A. T., Yiamouyiannis, C. A., Martin, B. J. and thetic nervous systems is a prerequi- Earl, R. A., Hart, S. D., Johnson, A. Watkins, J. B., III: Chronic physical site for pressor and tachycardic ef- L., Ma, P., McCall, D. E., Price, W. activity alters hepatobiliary excne- fects of dipheny!eneiodonium, a A., Jr., Smith, R. D., Wexler, R. R. tory function in rats, 321 novel inhibitor of nitric oxide syn- and Timmermans, P. B. M. W. M.: Yoburn, B. C., Billings, B. and Duttanoy, A.: thase, 263 Pharmacology of 2-amino-1,4-dihy- Opioid receptor regulation in mice, Watanabe, K., see Hone, S., 1313 dro-4-(2-4-[4-(2-methoxypheny!)-1- 314 Watkins, J. B., III, see Yiamouyiannis, C. piperazinyl]buty!sulfinyflphenyl)-6- Yokota, T., see Tamura, Y., 1017 A., 321 methyl-5-nitno-3-pynidine carboxylic Yoshiyama, M., Roppolo, J. R. and de Groat, Watts, V. J., see Lysle, D. T., 1071 acid methyl ester (XB513), a novel W. C.: Effects of MK-80l on the mic- Waxman, D. J., see Shapiro, B. H., 979 calcium agonist with alpha-i adre- tunition reflex in the rat-possible Weber, S., see Horan, P. J., 1446 nergic receptor antagonistic prop- sites of action, 844 Weber, S. J., see Horan, P. J., 896 erty, 1088 Young, M. B., see Lynch, J. J., Jr., 720 Wegner, C. D., see Farina, P. R., 483 Workman, P., see Walton, M. I., 938 Yurdaydin, C., Gu, Z.-Q., Nowak, G., Wei, E. T., see Gao, G. C., 619 Wyche, J. H., see Han, Z., 790 Fromm, C., Holt, A. G. and Basile, A. Weinger, M. B., see Negus, S. S., 1245 S.: Benzodiazepine receptor ligands XB513, pharmacology (rats), 1088 Welch, S. P.: Blockade of cannabinoid-in- are elevated in an animal model of Xenopsin, inhibition of vascular leakage, duced antinociception by nonbina!- hepatic encephalopathy: Relation- tissue injury (rats), 619 torphimine, but not N,N-dial!yl- ship between brain concentration Xiao, W.-B., Nordberg, A. and Zhang, X.: tryosine-aib-phenylalanine-leucine and severity of encephalopathy, 565 Effect of in vivo microdialysis of 1,2, IC! 174,864 or naloxone in mice, 633 3,4-tetrahydro-9-aminoacnidine Zacopride, nicotinic antinociception, adre- Wenger, G. R., see Hudzik, T. J., 120 (THA) on the extracellular concen- nergic, senotonengic and cholinergic Wexler, R. R., see Wong, P. C., 1088 tration of acetylcho!ine in the stnia- components (rats), 777 Wheeler, T. N., see Shaffer, J. E., 1105 turn of anesthetized rats, 759 Zadina, J. E., Chang, S. L., Ge, L.-J. and White, D. A., see Fleming, N. W., 1199 Xu, J., see Contrera, J. G., 433 Kastin, A. J.: Mu opiate receptor White, F. J., see Ackerman, J. M., 963 Xue, H., see Bukoski, R. D., 30 down-regulation by morphine and Wientjes, M. G., see Bramer, S. L., 731 up-regulation by naloxone in SH- Wilcox, G. L., see Alhaiden, A. A., 378 Yakehiro, M., Yamamoto, S., Baba, N., Na- SY5Y human neuroblastoma cells, Wild, K. D., see Horan, P. J.,896 kajima, S., Iwasa, J. and Seyama, I.: 254 Willets, J., Clissold, D. B., Hantman, T. L., Structure-activity relationship forD- Zajac, J. M., see Million, M., 96 Brandsgaard, R. R., Hamilton, G. S. ring derivatives of grayanotoxin in Zeidel, M. L., see Brady, H. R., 1421 and Ferkany, J. W.: Behavioral phar- the squid giant axon, 1328 Zhang, X., see Xiao, W.-B., 759 macology of NPC 17742, a competi- Yamamoto, S., see Yakehiro, M., 1328 Zhou, Q., see Lovinger, D. M., 771 tive N-methyl-D-aspartate (NMDA) Yamamuna, H. I.,see Horan, P. J., 896, 1446 Zinc, thermal and chemical tolerance, trans- antagonist, 1055 Yamashita, I.,see Matsubana, S., 498 epithelial transport, renal epithelium Wilson, E. J., see Wang, L., 308 Yanagisawa, T., see Kageyama, M., 490 (flounder), 992 Winer, N., see El Alj, A., 1205 Yano, S., see Hone, S., 1313 Zingaro, G. J., see Lynch, J. J., Jr., 720 Wishka, D. G., see Benjamin, C. W., 457 Yasar, S., Schindler, C. W., Thorndike, E. Zofenopni!, cardioprotection, myocandial is- Wojcik, W. J., see Contrera, J. G., 433 B., Szelenyi, I. and Goldberg, S. R.: chemia, ATP-sensitive potassium Wojcik, W. J., see Longone, P., 441 Evaluation of the stereoisomers of channel (rats), 609