Product Name: C1orf127 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated Catalog No

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Product Name: C1orf127 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated Catalog No. : TAP01-84985R-A488 Intended Use: For Research Use Only. Not for used in diagnostic procedures. Size 100ul Concentration 1ug/ul Gene ID ISO Type Rabbit IgG Clone N/A Immunogen Range Conjugation ALEXA FLUOR® 488 Subcellular Locations Applications IF(IHC-P) Cross Reactive Species Human, Mouse, Rat Source KLH conjugated synthetic peptide derived from human C1orf127 Applications with IF(IHC-P)(1:50-200) Dilutions Purification Purified by Protein A. Background Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanomaand multiple myeloma. The C1orf127 gene product has been provisionally designated C1orf127 pending further characterization. Synonyms Chromosome 1 open reading frame 127; FLJ37118; FLJ37833; Hypothetical protein LOC148345; CA127_HUMAN. Storage Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support at [email protected] or your distributor service. .

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A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
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