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127 Advances in Biochemical Engineering/Biotechnology 127 Advances in Biochemical Engineering/Biotechnology Series Editor: T. Scheper Editorial Board: S. Belkin • I. Endo • S.-O. Enfors • W.-S. Hu B. Mattiasson • J. Nielsen • G. Stephanopoulos • G. T. Tsao R. Ulber • A.-P. Zeng • J.-J. Zhong • W. Zhou Advances in Biochemical Engineering/Biotechnology Series Editor: T. Scheper Recently Published and Forthcoming Volumes Genomics and Systems Biology of Nano/Micro Biotechnology Mammalian Cell Culture Volume Editors: Endo, I., Nagamune, T. Volume Editors: Hu, W.-S., Zeng, A.-P. Vol. 119, 2010 Vol. 127, 2012 Whole Cell Sensing Systems II Tissue Engineering III: Cell - Surface Volume Editors: Belkin, S., Gu, M.B. Interactions for Tissue Culture Vol. 118, 2010 Volume Editors: Kasper, C., Witte, F., Pörtner, R. Whole Cell Sensing Systems I Vol. 126, 2012 Volume Editors: Belkin, S., Gu, M.B. Vol. 117, 2010 Biofunctionalization of Polymers and their Applications Optical Sensor Systems in Biotechnology Volume Editors: Nyanhongo G.S., Volume Editor: Rao, G. Steiner W., Gübitz, G.M. Vol. 116, 2009 Vol. 125, 2011 Disposable Bioreactors High Resolution Microbial Volume Editor: Eibl, R., Eibl, D. Single Cell Analytics Vol. 115, 2009 Volume Editors: Müller S., Bley, T. Engineering of Stem Cells Vol. 124, 2011 Volume Editor: Martin, U. Vol. 114, 2009 Bioreactor Systems for Tissue Engineering II Biotechnology in China I Strategies for the Expansion From Bioreaction to Bioseparation and and Directed Differentiation Bioremediation of Stem Cells Volume Editors: Zhong, J.J., Bai, F.-W., Volume Editors: Kasper C., Zhang, W. van Griensven M., Vol. 113, 2009 Pörtner, R. Bioreactor Systems for Tissue Vol. 123, 2010 Engineering Biotechnology in China II Volume Editors: Kasper, C., Chemicals, Energy and Environment van Griensven, M., Poertner, R. Volume Editors: Tsao, G.T., Ouyang, P., Vol. 112, 2008 Chen, J. Food Biotechnology Vol. 122, 2010 Volume Editors: Stahl, U., Donalies, U. E. B., Nevoigt, E. Biosystems Engineering II Vol. 111, 2008 Linking Cellular Networks and Bioprocesses Volume Editors: Wittmann, C., Krull, R. Protein-Protein Interaction Vol. 121, 2010 Volume Editors: Seitz, H., Werther, M. Vol. 110, 2008 Biosystems Engineering I Creating Superior Biocatalysts Biosensing for the 21st Century Volume Editors: Wittmann, C., Krull, R. Volume Editors: Renneberg, R., Lisdat, F. Vol. 120, 2010 Vol. 109, 2007 Genomics and Systems Biology of Mammalian Cell Culture Volume Editors: Wei-Shou Hu Á An-Ping Zeng With contributions by M. Berger Á V. Blanchard Á L. Botezatu Á M. Castro-Melchor C. Clemens Á L. Gama-Norton Á Z. P. Gerdtzen Á H. Hauser E. Heinzle Á B. Hitzmann Á P. Hossler Á W.-S. Hu Á U. Jandt C. Kasper Á H. Kaufmann Á M. Kaup Á D. Landgrebe H. Le Á M. Lübbecke Á K. Mutz Á J. Niklas Á J. Schaub T. Scheper Á R. Schucht Á T. W. Schulz Á S. Sievers F. Stahl Á J. Walter Á D. Wirth Á A.-P. Zeng 123 Editors Prof. Dr. Wei-Shou Hu Prof. Dr. An-Ping Zeng Department of Chemical Engineering Technische Universität Hamburg-Harburg and Material Institut für Bioprozess- und University of Minnesota Biosystemtechnik Washington Ave. SE 421 Denickestr. 15 Minneapolis MN 55455 21073 Hamburg USA Germany ISSN 0724-6145 e-ISSN 1616-8542 ISBN 978-3-642-28349-9 e-ISBN 978-3-642-28350-5 DOI 10.1007/978-3-642-28350-5 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012931409 Ó Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Series Editor Prof. Dr. T. Scheper Institute of Technical Chemistry University of Hannover Callinstraße 3 30167 Hannover, Germany [email protected] Volume Editors Prof. Dr. Wei-Shou Hu Prof. Dr. An-Ping Zeng Department of Chemical Engineering Technische Universität Hamburg-Harburg and Material Institut für Bioprozess- und University of Minnesota Biosystemtechnik Washington Ave. SE 421 Denickestr. 15 Minneapolis MN 55455 21073 Hamburg USA Germany Editorial Board Prof. Dr. S. Belkin Prof. Dr. W.-S. Hu Interfaculty Biotechnology Program Chemical Engineering Institute of Life Sciences and Materials Science The Hebrew University of Jerusalem University of Minnesota Jerusalem 91904, Israel 421 Washington Avenue SE [email protected] Minneapolis, MN 55455-0132, USA [email protected] Prof. Dr. I. Endo Prof. Dr. B. Mattiasson Saitama Industrial Technology Center 3-12-18, Kamiaoki Kawaguchi-shi Department of Biotechnology Saitama, 333-0844, Japan Chemical Center, Lund University [email protected] P.O. Box 124, 221 00 Lund, Sweden [email protected] vi Editorial Board Prof. Dr. S.-O. Enfors Prof. Dr. J. Nielsen Department of Biochemistry Chalmers University of Technology and Biotechnology Department of Chemical and Biological Royal Institute of Technology Engineering Teknikringen 34, Systems Biology 100 44 Stockholm, Sweden Kemivägen 10 [email protected] 41296 Göteborg Sweden Prof. Dr. G. Stephanopoulos [email protected] Department of Chemical Engineering Prof. Dr. J.-J. Zhong Massachusetts Institute of Technology Cambridge, MA 02139-4307, USA Bio-Building #3-311 [email protected] College of Life Science & Biotechnology Key Laboratory of Microbial Metabolism, Prof. Dr. G. T. Tsao Ministry of Education Shanghai Jiao Tong University Professor Emeritus 800 Dong-Chuan Road Purdue University Minhang, Shanghai 200240, China West Lafayette, IN 47907, USA [email protected] [email protected] [email protected] Dr. W. Zhou Prof. Dr. Roland Ulber Sr. Director, BioProcess Engineering Technology Development FB Maschinenbau und Verfahrenstechnik Genzyme Corporation Technische Universität Kaiserslautern 45 New York Avenue Gottlieb-Daimler-Straße Framingham, MA 01701-9322, USA 67663 Kaiserslautern, Germany [email protected] [email protected] Prof. Dr. A.-P. Zeng Technische Universität Hamburg-Harburg Institut für Bioprozess- und Biosystem- technik Denickestrasse 1 21073 Hamburg, Germany [email protected] Honorary Editor Founding Editors Prof. Dr. K. Schügerl Prof. Dr. Armin Fiechter University of Hannover Zurich, Switzerland Germany Prof. Dr. Tarun Ghose New Delhi, India Advances in Biochemical Engineering/Biotechnology Advances in Biochemical Engineering/Biotechnology is included in Springer’s ebook package Chemistry and Materials Science. If a library does not opt for the whole package the book series may be bought on a subscription basis. Also, all back volumes are available electronically. For all customers who have a standing order to the print version of Advances in Biochemical Engineering/Biotechnology, we offer free access to the electronic volumes of the Series published in the current year via SpringerLink. If you do not have access, you can still view the table of contents of each volume and the abstract of each article by going to the SpringerLink homepage, clicking on ‘‘Chemistry and Materials Science,’’ under Subject Collection, then ‘‘Book Series,’’ under Content Type and finally by selecting Advances in Bio- chemical Bioengineering/Biotechnology You will find information about the • Editorial Board • Aims and Scope • Instructions for Authors • Sample Contribution at springer.com using the search function by typing in Advances in Biochemical Engineering/Biotechnology. Color figures are published in full color in the electronic version on Sprin- gerLink. vii viii Advances in Biochemical Engineering/Biotechnology Aims and Scope Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes
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