127 Advances in Biochemical Engineering/Biotechnology Series Editor: T. Scheper Editorial Board: S. Belkin • I. Endo • S.-O. Enfors • W.-S. Hu B. Mattiasson • J. Nielsen • G. Stephanopoulos • G. T. Tsao R. Ulber • A.-P. Zeng • J.-J. Zhong • W. Zhou Advances in Biochemical Engineering/Biotechnology Series Editor: T. Scheper Recently Published and Forthcoming Volumes Genomics and Systems Biology of Nano/Micro Biotechnology Mammalian Cell Culture Volume Editors: Endo, I., Nagamune, T. Volume Editors: Hu, W.-S., Zeng, A.-P. Vol. 119, 2010 Vol. 127, 2012 Whole Cell Sensing Systems II Tissue Engineering III: Cell - Surface Volume Editors: Belkin, S., Gu, M.B. Interactions for Tissue Culture Vol. 118, 2010 Volume Editors: Kasper, C., Witte, F., Pörtner, R. Whole Cell Sensing Systems I Vol. 126, 2012 Volume Editors: Belkin, S., Gu, M.B. Vol. 117, 2010 Biofunctionalization of Polymers and their Applications Optical Sensor Systems in Biotechnology Volume Editors: Nyanhongo G.S., Volume Editor: Rao, G. Steiner W., Gübitz, G.M. Vol. 116, 2009 Vol. 125, 2011 Disposable Bioreactors High Resolution Microbial Volume Editor: Eibl, R., Eibl, D. Single Cell Analytics Vol. 115, 2009 Volume Editors: Müller S., Bley, T. Engineering of Stem Cells Vol. 124, 2011 Volume Editor: Martin, U. Vol. 114, 2009 Bioreactor Systems for Tissue Engineering II Biotechnology in China I Strategies for the Expansion From Bioreaction to Bioseparation and and Directed Differentiation Bioremediation of Stem Cells Volume Editors: Zhong, J.J., Bai, F.-W., Volume Editors: Kasper C., Zhang, W. van Griensven M., Vol. 113, 2009 Pörtner, R. Bioreactor Systems for Tissue Vol. 123, 2010 Engineering Biotechnology in China II Volume Editors: Kasper, C., Chemicals, Energy and Environment van Griensven, M., Poertner, R. Volume Editors: Tsao, G.T., Ouyang, P., Vol. 112, 2008 Chen, J. Food Biotechnology Vol. 122, 2010 Volume Editors: Stahl, U., Donalies, U. E. B., Nevoigt, E. Biosystems Engineering II Vol. 111, 2008 Linking Cellular Networks and Bioprocesses Volume Editors: Wittmann, C., Krull, R. Protein-Protein Interaction Vol. 121, 2010 Volume Editors: Seitz, H., Werther, M. Vol. 110, 2008 Biosystems Engineering I Creating Superior Biocatalysts Biosensing for the 21st Century Volume Editors: Wittmann, C., Krull, R. Volume Editors: Renneberg, R., Lisdat, F. Vol. 120, 2010 Vol. 109, 2007 Genomics and Systems Biology of Mammalian Cell Culture Volume Editors: Wei-Shou Hu Á An-Ping Zeng With contributions by M. Berger Á V. Blanchard Á L. Botezatu Á M. Castro-Melchor C. Clemens Á L. Gama-Norton Á Z. P. Gerdtzen Á H. Hauser E. Heinzle Á B. Hitzmann Á P. Hossler Á W.-S. Hu Á U. Jandt C. Kasper Á H. Kaufmann Á M. Kaup Á D. Landgrebe H. Le Á M. Lübbecke Á K. Mutz Á J. Niklas Á J. Schaub T. Scheper Á R. Schucht Á T. W. Schulz Á S. Sievers F. Stahl Á J. Walter Á D. Wirth Á A.-P. Zeng 123 Editors Prof. Dr. Wei-Shou Hu Prof. Dr. An-Ping Zeng Department of Chemical Engineering Technische Universität Hamburg-Harburg and Material Institut für Bioprozess- und University of Minnesota Biosystemtechnik Washington Ave. SE 421 Denickestr. 15 Minneapolis MN 55455 21073 Hamburg USA Germany ISSN 0724-6145 e-ISSN 1616-8542 ISBN 978-3-642-28349-9 e-ISBN 978-3-642-28350-5 DOI 10.1007/978-3-642-28350-5 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2012931409 Ó Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. 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Scheper Institute of Technical Chemistry University of Hannover Callinstraße 3 30167 Hannover, Germany [email protected] Volume Editors Prof. Dr. Wei-Shou Hu Prof. Dr. An-Ping Zeng Department of Chemical Engineering Technische Universität Hamburg-Harburg and Material Institut für Bioprozess- und University of Minnesota Biosystemtechnik Washington Ave. SE 421 Denickestr. 15 Minneapolis MN 55455 21073 Hamburg USA Germany Editorial Board Prof. Dr. S. Belkin Prof. Dr. W.-S. Hu Interfaculty Biotechnology Program Chemical Engineering Institute of Life Sciences and Materials Science The Hebrew University of Jerusalem University of Minnesota Jerusalem 91904, Israel 421 Washington Avenue SE [email protected] Minneapolis, MN 55455-0132, USA [email protected] Prof. Dr. I. Endo Prof. Dr. B. Mattiasson Saitama Industrial Technology Center 3-12-18, Kamiaoki Kawaguchi-shi Department of Biotechnology Saitama, 333-0844, Japan Chemical Center, Lund University [email protected] P.O. Box 124, 221 00 Lund, Sweden [email protected] vi Editorial Board Prof. Dr. S.-O. Enfors Prof. Dr. J. Nielsen Department of Biochemistry Chalmers University of Technology and Biotechnology Department of Chemical and Biological Royal Institute of Technology Engineering Teknikringen 34, Systems Biology 100 44 Stockholm, Sweden Kemivägen 10 [email protected] 41296 Göteborg Sweden Prof. Dr. G. Stephanopoulos [email protected] Department of Chemical Engineering Prof. Dr. J.-J. Zhong Massachusetts Institute of Technology Cambridge, MA 02139-4307, USA Bio-Building #3-311 [email protected] College of Life Science & Biotechnology Key Laboratory of Microbial Metabolism, Prof. Dr. G. T. Tsao Ministry of Education Shanghai Jiao Tong University Professor Emeritus 800 Dong-Chuan Road Purdue University Minhang, Shanghai 200240, China West Lafayette, IN 47907, USA [email protected] [email protected] [email protected] Dr. W. Zhou Prof. Dr. Roland Ulber Sr. Director, BioProcess Engineering Technology Development FB Maschinenbau und Verfahrenstechnik Genzyme Corporation Technische Universität Kaiserslautern 45 New York Avenue Gottlieb-Daimler-Straße Framingham, MA 01701-9322, USA 67663 Kaiserslautern, Germany [email protected] [email protected] Prof. Dr. A.-P. Zeng Technische Universität Hamburg-Harburg Institut für Bioprozess- und Biosystem- technik Denickestrasse 1 21073 Hamburg, Germany [email protected] Honorary Editor Founding Editors Prof. Dr. K. Schügerl Prof. Dr. Armin Fiechter University of Hannover Zurich, Switzerland Germany Prof. Dr. Tarun Ghose New Delhi, India Advances in Biochemical Engineering/Biotechnology Advances in Biochemical Engineering/Biotechnology is included in Springer’s ebook package Chemistry and Materials Science. If a library does not opt for the whole package the book series may be bought on a subscription basis. Also, all back volumes are available electronically. 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Color figures are published in full color in the electronic version on Sprin- gerLink. vii viii Advances in Biochemical Engineering/Biotechnology Aims and Scope Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes