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WORLD TRADE ORGANIZATION ORGANISATION MONDIALE DU COMMERCE ORGANIZACIÓN MUNDIAL DEL COMERCIO Reference: WLI/100 31 January 2008 MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION DONE AT MARRAKESH ON 15 APRIL 1994 GENERAL AGREEMENT ON TARIFFS AND TRADE 1994 CERTIFICATION OF MODIFICATIONS AND RECTIFICATIONS TO SCHEDULE XXXVIII – JAPAN TRANSMISSION OF CERTIFIED TRUE COPY I have the honour to furnish herewith a certified true copy of the Certification of Modifications and Rectifications to Schedule XXXVIII – Japan, effective 22 January 2008. Pascal Lamy Director-General 08-0463 WT/Let/610 Centre William Rappard Rue de Lausanne 154 Case postale CH - 1211 Genève 21 Téléphone: (+41 22) 739 51 11 Fax: (+41 22) 731 42 06 Internet: http://www.wto.org SCHEDULES OF TARIFF CONCESSIONS TO THE GENERAL AGREEMENT ON TARIFFS AND TRADE 1994 CERTIFICATION OF MODIFICATIONS AND RECTIFICATIONS, 22 January 2008 SCHEDULE XXXVIII – JAPAN WHEREAS the CONTRACTING PARTIES to the General Agreement on Tariffs and Trade 1947 adopted, on 26 March 1980, a Decision on Procedures for Modification and Rectification of Schedules of Tariff Concessions (BISD 27S/25); WHEREAS in accordance with the provisions of the above-mentioned Decision, the draft containing modifications and rectifications to Schedule XXXVIII – Japan was communicated to all Members in documents G/MA/TAR/RS/136, G/MA/TAR/RS/136/Corr.1 and G/MA/TAR/RS/136/Corr.2 and was approved on 22 January 2008; IT IS HEREBY CERTIFIED that the modifications and rectifications to Schedule XXXVIII – Japan are established in conformity with the above-mentioned Decision. The annexed modifications and rectifications to the Schedule become effective in accordance with the notification given to that effect by the Government of Japan to the Director-General of the World Trade Organization (hereinafter referred to as the "WTO") upon completion of Japan's internal procedures. This Certification is deposited with the Director-General of the WTO, who shall promptly furnish a certified true copy thereof to each Member of the WTO. It shall be registered in accordance with the provisions of Article 102 of the Charter of the United Nations. DONE at Geneva this twenty second day of January, two thousand and eight. Pascal Lamy Certified copy: Director-General MODIFICATIONS AND RECTIFICATIONS TO SCHEDULE XXXVIII - JAPAN Page 3 WT/Let/610 SCHEDULE XXXVIII – JAPAN 22 January 2008 Page 4 WT/Let/610 PART I MOST-FAVOURED-NATION TARIFF SECTION I Agricultural Products Mark the tariff item number 3504.00 with a letter "P". SECTION II Other Products Mark the tariff item numbers 2903.30, 2903.47, 2907.30 and 2913.00 with a letter "P". Page 5 WT/Let/610 Attachment to SCHEDULE XXXVIII – JAPAN Replace “Annexes IA, IB and IC” in category (3) by “Annexes IA, IB, IC and ID”. Replace “Annexes IA, IB and IC” in category (4) by “Annexes IA, IB, IC and ID”, and “Annexes IIA, IIB and IIC” by “Annex II”. Replace “Annexes IVA, IVB and IVC” in category (6) by “Annexes IVA, IVB, IVC and IVD”. Page 6 WT/Let/610 Insert the following Annex after Annex IC Annex ID Designated Pharmaceutical Active Ingredients (Additions by the third review) HS Subheading Description HS Subheading Description 2842.90 vangatalcite 2903.47 perflubrodec 2843.90 eptaplatin 2906.19 becocalcidiol 2843.90 miriplatin 2906.19 inecalcitol 2843.90 padoporfin 2907.30 alfatradiol 2843.90 picoplatin 2909.49 atocalcitol 2843.90 satraplatin 2909.49 fispemifene 2843.90 triplatin tetranitrate 2909.49 ospemifene 2844.40 technetium (99m Tc) fanolesomab 2909.50 soneclosan 2844.40 technetium (99m Tc) nitridocade 2914.40 irofulven 2844.40 yttrium (90 Y) tacatuzumab tetraxetan 2914.70 nebicapone 2845.90 deutolperisone 2915.39 anecortave 2846.90 gadocoletic acid 2915.90 arundic acid 2846.90 gadodenterate 2916.39 bexarotene 2846.90 gadofosveset 2918.19 icomucret 2846.90 gadomelitol 2918.19 tenivastatin 2903.30 perflexane 2918.19 tisocalcitate 2903.30 perflisobutane 2918.90 etalocib 2903.30 perflubutane 2918.90 gemcabene 2903.30 perflutren 2918.90 naveglitazar Page 7 WT/Let/610 HS Subheading Description HS Subheading Description 2918.90 tesaglitazar 2922.50 caloxetic acid 2918.90 travoprost 2922.50 desvenlafaxine 2921.30 neramexane 2922.50 etilevodopa 2921.49 cinacalcet 2922.50 fesoterodine 2921.49 delucemine 2922.50 fosveset 2921.49 levmetamfetamine 2922.50 isalmadol 2922.19 edronocaine 2922.50 melevodopa 2922.19 esoxybutynin 2922.50 ritobegron 2922.19 fingolimod 2922.50 solabegron 2922.19 mantabegron 2924.10 carglumic acid 2922.19 squalamine 2924.10 teglicar 2922.19 talibegron 2924.10 valrocemide 2922.19 tesmilifene 2924.29 aliskiren 2922.19 trodusquemine 2924.29 amiglumide 2922.19 xidecaflur 2924.29 arformoterol 2922.29 nolomirole 2924.29 axitirome 2922.29 tapentadol 2924.29 efaproxiral 2922.29 tecalcet 2924.29 frakefamide 2922.30 esketamine 2924.29 iosimenol 2922.49 eglumetad 2924.29 lacosamide 2922.49 icofungipen 2924.29 ladostigil 2922.49 lumiracoxib 2924.29 neboglamine 2922.49 robenacoxib 2924.29 oseltamivir 2922.50 axomadol 2924.29 ralfinamide Page 8 WT/Let/610 HS Subheading Description HS Subheading Description 2924.29 safinamide 2929.90 avasimibe 2924.29 salcaprozic acid 2929.90 banoxantrone 2924.29 salclobuzic acid 2929.90 disufenton sodium 2924.29 tabimorelin 2930.90 armodafinil 2924.29 tacedinaline 2930.90 canfosfamide 2924.29 talaglumetad 2930.90 desmeninol 2924.29 taltobulin 2930.90 dextiopronin 2924.29 topilutamide 2930.90 eflucimibe 2924.29 valategrast 2930.90 esonarimod 2925.20 amelubant 2930.90 exisulind 2925.20 anisperimus 2930.90 pemaglitazar 2925.20 delmitide 2930.90 rimeporide 2925.20 olanexidine 2930.90 tanomastat 2925.20 peramivir 2931.00 ibrolipim 2926.90 cilomilast 2931.00 lidadronic acid 2926.90 manitimus 2932.19 milataxel 2926.90 naminidil 2932.19 rostafuroxin 2926.90 teriflunomide 2932.29 alemcinal 2928.00 eplivanserin 2932.29 amotosalen 2928.00 istaroxime 2932.29 ascorbyl gamolenate 2928.00 marimastat 2932.29 disermolide 2928.00 meldonium 2932.29 firocoxib 2928.00 sardomozide 2932.29 fluorescein lisicol 2928.00 semapimod 2932.29 mitemcinal Page 9 WT/Let/610 HS Subheading Description HS Subheading Description 2932.29 rofecoxib 2933.29 dapiclermine 2932.29 selamectin 2933.29 dibotermin alfa 2932.99 artemotil 2933.29 doranidazole 2932.99 artenimol 2933.29 emfilermin 2932.99 carabersat 2933.29 enfuvirtide 2932.99 defoslimod 2933.29 eptotermin alfa 2932.99 dexbudesonide 2933.29 exenatide 2932.99 enrasentan 2933.29 fadolmidine 2932.99 escitalopram 2933.29 fampronil 2932.99 fondaparinux sodium 2933.29 fipamezole 2932.99 idraparinux sodium 2933.29 imidafenacin 2932.99 idronoxil 2933.29 lusupultide 2932.99 lirimilast 2933.29 mecasermin rinfabate 2932.99 omigapil 2933.29 olmesartan 2932.99 ortataxel 2933.29 palifermin 2932.99 osemozotan 2933.29 rebimastat 2932.99 oxeglitazar 2933.29 repifermin 2932.99 paclitaxel ceribate 2933.29 semparatide 2932.99 ramelteon 2933.29 tadekinig alfa 2932.99 tidembersat 2933.29 tiplimotide 2932.99 tonabersat 2933.39 adekalant 2933.29 abrineurin 2933.39 alvameline 2933.29 bifarcept 2933.39 alvimopan 2933.29 cipralisant 2933.39 ancriviroc Page 10 WT/Let/610 HS Subheading Description HS Subheading Description 2933.39 arimoclomol 2933.39 iferanserin 2933.39 atazanavir 2933.39 ilaprazole 2933.39 bamirastine 2933.39 indibulin 2933.39 barixibat 2933.39 ipravacaine 2933.39 bilastine 2933.39 ispronicline 2933.39 capravirine 2933.39 itriglumide 2933.39 caricotamide 2933.39 iturelix 2933.39 cipemastat 2933.39 lanicemine 2933.39 crobenetine 2933.39 levolansoprazole 2933.39 dabigatran 2933.39 lonafarnib 2933.39 dabigatran etexilate 2933.39 maraviroc 2933.39 dersalazine 2933.39 maropitant 2933.39 desloratadine 2933.39 miglustat 2933.39 dexlansoprazole 2933.39 minopafant 2933.39 dexmethylphenidate 2933.39 nerispirdine 2933.39 ecalcidene 2933.39 otamixaban 2933.39 elarofiban 2933.39 paliroden 2933.39 enzastaurin 2933.39 pipendoxifene 2933.39 esomeprazole 2933.39 prazarelix 2933.39 etoricoxib 2933.39 rimonabant 2933.39 ezlopitant 2933.39 rivanicline 2933.39 fidexaban 2933.39 senazodan 2933.39 gimeracil 2933.39 solimastat 2933.39 icaridin 2933.39 sorafenib Page 11 WT/Let/610 HS Subheading Description HS Subheading Description 2933.39 surinabant 2933.40 solifenacin 2933.39 tebanicline 2933.40 tafenoquine 2933.39 tecastemizole 2933.40 talnetant 2933.39 tenatoprazole 2933.40 tariquidar 2933.39 tesofensine 2933.40 torcetrapib 2933.39 ticalopride 2933.40 zelandopam 2933.39 timcodar 2933.40 zoniporide 2933.39 traxoprodil 2933.59 alamifovir 2933.39 varenicline 2933.59 albaconazole 2933.39 vatalanib 2933.59 ambrisentan 2933.39 vofopitant 2933.59 avanafil 2933.39 zanapezil 2933.59 balicatib 2933.40 alilusem 2933.59 cadrofloxacin 2933.40 gantacurium chloride 2933.59 caldaret 2933.40 garenoxacin 2933.59 dapivirine 2933.40 laniquidar 2933.59 darusentan 2933.40 meclinertant 2933.59 dasantafil 2933.40 olamufloxacin 2933.59 degarelix 2933.40 palosuran 2933.59 detiviciclovir 2933.40 pelitinib 2933.59 dofequidar 2933.40 pinokalant 2933.59 donitriptan 2933.40 pitavastatin 2933.59 emivirine 2933.40 pradofloxacin 2933.59 enecadin 2933.40 sitamaquine 2933.59 entecavir Page 12 WT/Let/610 HS Subheading Description HS Subheading Description 2933.59 erlotinib 2933.59 seliciclib 2933.59 esmirtazapine 2933.59 tandutinib 2933.59 etravirine 2933.59 tenofovir 2933.59 etriciguat 2933.59 tiviciclovir 2933.59 falnidamol 2933.59 valomaciclovir 2933.59 feloprentan 2933.59 vandetanib 2933.59 figopitant 2933.59 vestipitant 2933.59 forodesine 2933.59 zonampanel 2933.59 imatinib 2933.59
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    US007964607B2 (12) United States Patent (10) Patent N0.: US 7,964,607 B2 Verhoest et a1. (45) Date of Patent: Jun. 21, 2011 (54) PYRAZOLO[3,4-D]PYRIMIDINE FOREIGN PATENT DOCUMENTS COMPOUNDS EP 1460077 9/2004 WO 02085904 10/2002 (75) Inventors: Patrick Robert Verhoest, Old Lyme, CT WO 2004037176 5/2004 (US); Caroline ProulX-Lafrance, Ledyard, CT (US) OTHER PUBLICATIONS Wunder et a1, M01. PharmacoL, v01. 28, N0. 6, (2005), pp. 1776 (73) Assignee: P?zer Inc., New York, NY (U S) 1781. van der Staay et a1, Neuropharmacology, v01. 55 (2008), pp. 908 ( * ) Notice: Subject to any disclaimer, the term of this 918. patent is extended or adjusted under 35 USC 154(b) by 562 days. Primary Examiner * Susanna Moore (74) Attorney, Agent, or Firm * Jennifer A. Kispert; (21) Appl.No.: 12/118,062 Michael Herman (22) Filed: May 9, 2008 (57) ABSTRACT (65) Prior Publication Data The invention provides PDE9-inhibiting compounds of For US 2009/0030003 A1 Jan. 29, 2009 mula (I), Related US. Application Data (60) Provisional application No. 60/917,333, ?led on May 11, 2007. (51) Int. Cl. C07D 48 7/04 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01) (52) US. Cl. ................................... .. 514/262.1; 544/262 (58) Field of Classi?cation Search ................ .. 544/262; 5 1 4/2 62 .1 See application ?le for complete search history. and pharmaceutically acceptable salts thereof, Wherein R, R1, (56) References Cited R2 and R3 are as de?ned herein. Pharmaceutical compositions containing the compounds of Formula I, and uses thereof in U.S.
  • G Protein-Coupled Receptors

    G Protein-Coupled Receptors

    S.P.H. Alexander et al. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors. British Journal of Pharmacology (2015) 172, 5744–5869 THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: G protein-coupled receptors Stephen PH Alexander1, Anthony P Davenport2, Eamonn Kelly3, Neil Marrion3, John A Peters4, Helen E Benson5, Elena Faccenda5, Adam J Pawson5, Joanna L Sharman5, Christopher Southan5, Jamie A Davies5 and CGTP Collaborators 1School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK, 2Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK, 3School of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK, 4Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK, 5Centre for Integrative Physiology, University of Edinburgh, Edinburgh, EH8 9XD, UK Abstract The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/ 10.1111/bph.13348/full. G protein-coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading.
  • Axon Medchem

    Axon Medchem

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