Neurology and Clinical Neurophysiology: an Artificial Divide

Total Page:16

File Type:pdf, Size:1020Kb

Neurology and Clinical Neurophysiology: an Artificial Divide Editorial Pract Neurol: first published as 10.1136/practneurol-2021-002946 on 28 April 2021. Downloaded from Neurology and clinical neurophysiology: an artificial divide Matthew C Kiernan 1,2 1Brain and Mind Centre, The The editors of Practical Neurology ask a suggested that neurophysiological testing University of Sydney, Sydney, reasonable question: who is best placed should be undertaken by someone who New South Wales, Australia 2Department of Neurology, to oversee the neurophysiological investi- not only understands the patient’s neuro- Royal Prince Alfred Hospital, gation of patients presenting with neuro- logical presentation, but who can deter- Sydney, New South Wales, logical symptoms? Before considering the mine what is to be studied as the test is Australia complexities of this seemingly straightfor- being performed, and who can interpret Correspondence to ward question, it is accepted at the outset the findings in situ and in relation to Professor Matthew C Kiernan, that any physician or technician could be the patient’s clinical presentation and Brain and Mind Centre, The trained to follow a testing proforma based phenotype. University of Sydney, Sydney, New South Wales, Australia; on a symptom, or constellation of symp- Before considering the more complex matthew. kiernan@ sydney. toms. So, the question does not relate to answer to the original question, we must edu. au an issue of capability, nor should it relate agree that whoever undertakes the testing Accepted 5 April 2021 to capacity. Rather, it would seem logical should be sufficiently trained and have Published Online First to consider how the best outcome can be appropriate experience with the testing 28 April 2021 achieved—that is, to diagnose the cause apparatus and techniques. Essentially, that that underlies a patient’s symptoms. means dedicated training (fellowship) and Clinical neurophysiology forms part supervision, followed by a period of tran- of a neurologist’s array of instruments sition from trainee to accredited service and tests that, carefully coordinated, provider. In many countries, neurophys- yields the most rewarding and sometimes iological testing is undertaken by neurol- surprising results. At its simplest level, ogists. In others, particularly in Europe, it represents a technology platform that training in clinical neurophysiology and aids the diagnosis and management of the provision of electrodiagnostic services patients with neurological disease. More has branched off to become a stand- http://pn.bmj.com/ fundamentally, however, it is indispens- alone specialty, separate to neurology. able for differentiating myopathic from The potential benefits of this approach neuropathic causes of weakness; and include a review by a second set of eyes, for determining the pattern of neuro- an increase in practice within the specific genic abnormality.1 Critically, clinical area, and the saving of time. neurophysiology can assist in the diag- In the standalone model, after a consul- on September 29, 2021 by guest. Protected copyright. nosis and localisation of a lesion, and in tation with a neurologist, the patient staging the development or recovery from presenting with limb weakness would neurological diseases. In the presence of receive a referral to a new specialist to neurogenic abnormalities, electromyog- undertake diagnostic neurophysiological raphy (EMG) studies can reveal changes testing. In such a setting, it is accepted of denervation that are not apparent or that many of the subtleties garnered not definite by means of clinical exam- through the clinical history and exam- ination.2–4 As such, the EMG machine ination (as undertaken by the now refer- can be considered akin to an electrical ring neurologist) would largely fall by stethoscope: it enables the neurologist to the wayside. Having received a referral, © Author(s) (or their detect clinical signs that often cannot be the clinical neurophysiologist would then employer(s)) 2021. No identified by clinical examination. What it develop their perspective on the presenta- commercial re- use. See rights and permissions. Published reveals and subsequently achieves for each tion, to determine a process of testing that by BMJ. patient will vary, even when the patho- would aid the diagnosis of the patient’s To cite: Kiernan MC. logical condition is the same, depending condition. These simple acts of process Pract Neurol 2021;21:274– on that particular patient’s clinical symp- segregation serve no real purpose, other 275. toms and signs. In this setting, it could be than being service (specialty) driven, and 274 Kiernan MC. Pract Neurol 2021;21:274–275. doi:10.1136/practneurol-2021-002946 Editorial Pract Neurol: first published as 10.1136/practneurol-2021-002946 on 28 April 2021. Downloaded from certainly provide no added benefit for the patient. On Taken from a different perspective, were you to ask the contrary, there remains potential for a relatively aspiring neurologists as to their preference—undertake simple process to be subjugated, with the possibility their own neurophysiological testing, or outsource it that the clinical neurophysiologist embarks on a course to a separate craft group—I would venture to guess of testing that may not answer the question posed by that those with a relevant subspecialty interest, where the referring neurologist—namely, what is the cause neurophysiological testing forms part of standard of the patient’s weakness?—which becomes lost in patient diagnostic workup and monitoring, would ask translation. Furthermore, the clinical neurophysiol- to turn on the power, activate their electrical stetho- ogist remains separated from the process, and is not scopes and listen to the music. responsible for subsequent treatment and patient management. Twitter Matthew C Kiernan @JNNP_BMJ Of course, with any service, there are inevitable Contributors MCK is the sole author. issues related to supply and demand, and indeed Funding This study was funded by National Health and 5 Medical Research Council of Australia Programme Grant financial considerations. However, such matters (#1132524), Partnership Project (1153439) and Practitioner should not be the core consideration when asking Fellowship (1156093). who is best placed to undertake the neurophysiolog- Competing interests MCK serves as Editor- in- Chief of the ical testing of patients presenting with neurological Journal of Neurology, Neurosurgery & Psychiatry (BMJ, UK). problems. From an historical perspective, neurophys- Patient consent for publication Not required. iology from its inception has been intimately linked Provenance and peer review Commissioned; externally peer to neurology, and particularly neurological discovery. reviewed by Nick Kane, Bristol, UK. Over more recent decades, it has been the key pathway ORCID iD to unlock patient symptomatology and, in many cases, Matthew C Kiernan http:// orcid. org/ 0000-0001- 9054- 026X the clinical phenotype. Perhaps this mutually depen- dent relationship was best described by EA Carmichael REFERENCES through his guiding philosophy that the best way to 1 Rubin DI. Needle electromyography: basic concepts. Handb study neurological disease was to study human phys- Clin Neurol 2019;160:243–56. iology.6 While the use of technology has permeated 2 Shefner JM, Al- Chalabi A, Baker MR, et al. A proposal for new diagnostic criteria for ALS. Clin Neurophysiol all subspecialty endeavours—from neurogenetics 2020;131:1975–8. through to neuroimaging—the key contributions of 3 Yeh WZ, Dyck PJ, van den Berg LH, et al. Multifocal motor clinical neurophysiology have been increasingly hard- neuropathy: controversies and priorities. J Neurol Neurosurg wired into the modern- day practice of neurology. By Psychiatry 2020;91:140–8. analogy, one could also reasonably ask why neurolo- 4 Garg N, Park SB, Vucic S, et al. Differentiating lower gists do not report brain scans. In consort, the land- motor neuron syndromes. J Neurol Neurosurg Psychiatry scape is rapidly changing, and taking the field of stroke 2017;88:474–83. http://pn.bmj.com/ neurology and endovascular clot retrieval as cases in 5 Nuwer MR, Duncan M, Nuwer JM. A profile of Neurology practice based on Medicare services: an AAN medical economics point, this change has already occurred, with neurol- and management Committee report. American Academy of ogists reporting scans of their patients, as well as the Neurology. Neurology 2001;56:586–91. intervention. Would this report be better coming from 6 Merton PA. The first Carmichael memorial lecture. a radiologist, divorced from the patient, the clinical neurophysiology on man. J Neurol Neurosurg Psychiatry on September 29, 2021 by guest. Protected copyright. presentation, the intervention and the outcome? 1981;44:861–70. Kiernan MC. Pract Neurol 2021;21:274–275. doi:10.1136/practneurol-2021-002946 275.
Recommended publications
  • Psychiatry and Neurology
    ensic For Ps f yc o h l a o l n o r g u y o J ISSN: 2475-319X Journal of Forensic Psychology Editorial Psychiatry and Neurology Carlos Roberto* Department of Psychology, La Sierra University, California, USA DESCRIPTION between neurological and psychiatric disorders. for instance , it's documented that a lot of patients with paralysis agitans and Psychiatry is that the medicine dedicated to the diagnosis, stroke manifest depression and, in some, dementia. Is there a prevention, and treatment of mental disorders. These include substantive difference between a toxic psychosis (psychiatry) and various maladaptation’s associated with mood, behavior, a metabolic encephalopathy with delirium (neurology) we've cognition, and perceptions. See glossary of psychiatry. known of those examples for several years? Never and dramatic evidence has come largely through functional resonance imaging Neurology is that the branch of drugs concerned with the study and positron emission tomography. Obsessive-compulsive and treatment of disorders of the system nervosum. The system a disorder is characterized by recurrent, unwanted, intrusive ideas, nervosum may be a complex, sophisticated system that regulates images, or impulses that appear silly, weird, nasty, or horrible and coordinates body activities. Its two major divisions: Central nervous system: the brain and medulla spinalis. (obsessions) and by urges to hold out an act (compulsions) which will lessen the discomfort thanks to the obsessions. Increasing the amount of brain serotonin with selective reuptake inhibitors DIFFERENCE BETWEEN PSYCHITARY may control the symptoms and signs of this disorder. Evidence AND NEUROLOGY of a genetic basis in some patients, structural abnormalities of the brain on resonance imaging in others, and abnormal brain For quite 2000 years within the West, neurology and psychiatry function on functional resonance imaging and positron were thought to be a part of one, unified branch of drugs, which emission tomography collectively suggest that schizophrenia may was often designated neuropsychiatry.
    [Show full text]
  • Clinical Neurophysiology (CNP) Section Resident Core Curriculum
    American Academy of Neurology Clinical Neurophysiology (CNP) Section Resident Core Curriculum 9/7/01 Definition of the Subspecialty of Clinical Neurophysiology The subspecialty of Clinical Neurophysiology involves the assessment of function of the central and peripheral nervous system for the purpose of diagnosing and treatment of neurologic disorders. The CNP procedures commonly used include EEG, EMG, evoked potentials, polysomnography, epilepsy monitoring, intraoperative monitoring, evaluation of movement disorders, and autonomic nervous system testing. The use of CNP procedures requires an understanding of neurophysiology, clinical neurology, and the findings that can occur in various neurologic disorders. The following are the recommended CORE curriculum for residents re CNP. Basic Neurophysiology: Membrane properties of nerve and muscle potentials (resting, action, synaptic, generator), ion channels, synaptic transmission, physiologic basis of EEG, EMG, evoked potentials, sleep mechanisms, autonomic disorders, epilepsy, neuromuscular diseases, and movement disorders Anatomic Substrates of EEG, EMG, evoked potentials, sleep and autonomic activity Indications: Know the indications for and the interpretation of the various CNP tests in the context of the clinical problem. EEG: 1. Recognize normal EEG patterns of infants, children, and adults 2. Recognize abnormal EEG patterns and their clinical significance, including epileptiform patterns, coma patterns, periodic patterns, and the EEG patterns seen with various focal and diffuse neurologic and systemic disorders. 3. Know the EEG criteria for recording in suspected brain death EMG: 1. Know the normal parameters of nerve conduction studies and needle exam of infants, children, and adults 2. Know the abnormal patterns of nerve conduction studies and needle exam and the clinical correlates with various diseases that affect the neuromuscular and peripheral nervous system Evoked Potential Studies 1.
    [Show full text]
  • Behavioral Neurology Fellowship Core Curriculum
    AMERICAN ACADEMY OF NEUROLOGY BEHAVIORAL NEUROLOGY FELLOWSHIP CORE CURRICULUM 1. INTRODUCTION AND DEFINITIONS The specialty of Behavioral Neurology focuses on clinical and pathological aspects of neural processes associated with mental activity, subsuming cognitive functions, emotional states, and social behavior. Historically, the principal emphasis of Behavioral Neurology has been to characterize the phenomenology and pathophysiology of intellectual disturbances in relation to brain dysfunction, clinical diagnosis, and treatment. Representative cognitive domains of interest include attention, memory, language, high-order perceptual processing, skilled motor activities, and "frontal" or "executive" cognitive functions (adaptive problem-solving operations, abstract conceptualization, insight, planning, and sequencing, among others). Advances in cognitive neuroscience afforded by functional brain imaging techniques, electrophysiological methods, and experimental cognitive neuropsychology have nurtured the ongoing evolution and growth of Behavioral Neurology as a neurological subspecialty. Applying advances in basic neuroscience research, Behavioral Neurology is expanding our understanding of the neurobiological bases of cognition, emotions and social behavior. Although Behavioral Neurology and neuropsychiatry share some common areas of interest, the two fields differ in their scope and fundamental approaches, which reflect larger differences between neurology and psychiatry. Behavioral Neurology encompasses three general types of clinical
    [Show full text]
  • 640E Neurology Critical Care (Neuro Icu Core Rotation)
    Course Code: 97348 640E NEUROLOGY CRITICAL CARE (NEURO ICU CORE ROTATION) Course Description: This elective in Neuro Critical Care and ICU is designed to give the student increased exposure and autonomy in care of the Neurocritical care patient, including the medical treatment in acute neurological patients. Students function as sub interns, becoming integral members of the ICU team, and several primary caregivers under supervision. Department: Neurology Prerequisites: Successful completion of 1st and 2nd year curriculum. Successful completion of the 3rd year neurology core rotation Restrictions: This course does not accept international students Course Director: Sara Stern-Nezer, MD, UC Irvine Medical Center 200 S. Manchester Ave., Suite #206, Orange, CA 92868 Phone: 714-456-3565 Fax: 714-456-6894 Email: [email protected] Instructing Faculty: Cyrus Dastur, MD HS Clinical Professor of Neurology Leonid Groysman, MD HS Clinical Professor of Neurology Yama Akbari, MD PhD Clinical Professor of Neurology Sara Stern-Nezer, MD HS Clinical Professor of Neurology Frank P K Hsu, MD, PhD, Chair and Clinical Professor of Neurological Surgery Kiarash Golshani, MD Assistant Clinical Professor of Neurological Surgery Jefferson Chen, MD Assistant Clinical Professor of Neurological Surgery Shuichi Suzuki, MD, PhD, Assistant Clinical Professor of Neurological Surgery Course Website: http://www.neurology.uci.edu/overview.html Who to Report to First Day: Sara Stern-Nezer, MD, Neurology Clerkship Director / Stephanie Makhlouf, Neurology Education Coordinator Location to Report on First Day: UC Irvine Medical Center- Neurology Department, Conference Room, 200 Manchester Ave., Suite 206, Orange, CA 92868 Time to Report on First Day: 7:30 am Site: UC Irvine Medical Center Periods Available: Throughout the year Duration: 4 weeks Number of Students: 1 per block Scheduling Coordinator: UC Irvine students must officially enroll for the course by contacting the Scheduling Coordinator via email or phone (714) 456-8462 to make a scheduling appointment.
    [Show full text]
  • Inpatient and Emergency Neurology Quality Measurement Set
    Inpatient and Emergency Neurology Quality Measurement Set ©2016. American Academy of Neurology. All Rights Reserved. 1 CPT Copyright 2004-2016 American Medical Association. Disclaimer Performance Measures (Measures) and related data specifications developed by the American Academy of Neurology (AAN) are intended to facilitate quality improvement activities by providers. AAN Measures: 1) are not clinical guidelines and do not establish a standard of medical care, and have not been tested for all potential applications; 2) are not continually updated and may not reflect the most recent information; and 3) are subject to review and may be revised or rescinded at any time by the AAN. The measures, while copyrighted, can be reproduced and distributed, without modification, for noncommercial purposes (e.g., use by health care providers in connection with their practices); they must not be altered without prior written approval from the AAN. Commercial use is defined as the sale, license, or distribution of the measures for commercial gain, or incorporation of the measures into a product or service that is sold, licensed, or distributed for commercial gain. Commercial uses of the measures require a license agreement between the user and the AAN. Neither the AAN nor its members are responsible for any use of the measures. AAN Measures and related data specifications do not mandate any particular course of medical care and are not intended to substitute for the independent professional judgment of the treating provider, as the information does not account for individual variation among patients. In all cases, the selected course of action should be considered by the treating provider in the context of treating the individual patient.
    [Show full text]
  • Stanford University Neuroradiology Fellowship
    STANFORD UNIVERSITY NEURORADIOLOGY FELLOWSHIP The neuroradiology fellowship at Stanford University Medical Center is designed to be a well-balanced academic training program that encompasses all of the basic and advanced clinical and research areas of both adult and pediatric neuroradiology. The overall aims of this fellowship are two-fold: to produce neuroradiologists with the highest level of clinical expertise, and to produce the future leaders in academic neuroradiology. The goal of this fellowship program is for Neuroradiology fellows to develop knowledge, skills and attitudes necessary to properly evaluate, diagnose and manage patients with neurological, ENT and neurosurgical diseases. Therefore, this fellowship requires participation in clinical, research, and educational aspects of neuroradiology. Neuroradiology fellows will be exposed to all imaging modalities used to evaluate neurologic disease, including CT, MR, myelography, angiography, and imaging guided biopsies, during the course of the fellowship. Interventional neuroradiologic procedures are also performed at state-of-the-art levels at Stanford, and neuroradiology fellows will actively participate in these procedures. Goal of the Neuroradiology Fellowship Program Core Competencies Fellows should achieve the Interpersonal System following objectives: and -Based Patient Medical Practice-Based Communicati Professional Learni Care Knowledge Learning on Skills ism ng 1. Acquire specific knowledge about the physical principles of imaging modalities (CT,MR,ultrasound and digital subtraction angiography). X X 2. Identify the practical uses of CT, MR, ultrasound and digital subtraction angiography in the evaluation of neurologiocal, ENT and neurosurgical diseases. X X X 3. Develop thorough knowledge of the physical and physiological properties of contrast agents used in CT, MR, and angiography; including contraindications and management of potential complications.
    [Show full text]
  • 2021 Neurocritical Care CERT Information for Applicants
    2021 Information for Applicants Initial Certification Examination in Neurocritical Care The information contained in this document and the 2021 ABPN Board Policies Manual supersedes all previously printed publications concerning Board requirements, policies, and procedures. For the most current information, please visit our website at www.abpn.com. © 2020 American Board of Psychiatry and Neurology, Inc. Initial Certification Exam in Neurocritical Care Dates Choices October 4-8, 2021 Application Deadline April 6, 2021 Late Deadline April 27, 2021 2021 Fee Schedule* Application fee** $700 Examination fee $1200 Total Fee $1900 Miscellaneous Fees Late application fee (in addition to the above) $500 Reexamination fee*** $1200 International testing fee $100 Application/licensure appeal fee**** $350 Examination appeal fee**** $300 Irregular behavior appeal fee**** $350 Application for testing accommodations appeal fee**** $350 Duplicate certificate fee $150 Returned check charge $50 *All fees must be submitted in U.S. currency **Fee is non-refundable ***Reexamination fees are in addition to any appeal fees ****Appeal fees are refundable if the decision is in the appellant’s favor Please note: The ABPN reserves the right to revise fee schedule at any time. Throughout this publication, the American Board of Psychiatry and Neurology, Inc. may be referred to as “the Board” or as “ABPN”. ATTENTION VETERANS: Some or all of your exam fees may be reimbursed through the Department of Veterans Affairs. Please contact the DVA for further information. Important
    [Show full text]
  • Insensitivity to Future Consequences Following Damage to Human Prefrontal Cortex
    Cognition, 50 (1994) 7-15 OOlO-0277/94/$07.00 0 1994 - Elsevier Science B.V. All rights reserved. Insensitivity to future consequences following damage to human prefrontal cortex Antoine Bechara, Antonio R. Damasio*, Hanna Damasio, Steven W. Anderson Department of Neurology, Division of Behavioral Neurology and Cognitive Neuroscience, University of Iowa College of Medicine, Iowa City, IA 52242, USA Abstract Following damage to the ventromedial prefrontal cortex, humans develop a defect in real-life decision-making, which contrasts with otherwise normal intellectual functions. Currently, there is no neuropsychological probe to detect in the laboratory, and the cognitive and neural mechanisms responsible for this defect have resisted explanation. Here, using a novel task which simulates real-life decision-making in the way it factors uncertainty of premises and outcomes, as well as reward and punishment, we find that prefrontal patients, unlike controls, are oblivious to the future consequences of their actions, and seem to be guided by immediate prospects only. This finding offers, for the first time, the possibility of detecting these patients’ elusive impairment in the laboratory, measuring it, and investigating its possible causes. Introduction Patients with damage to the ventromedial sector of prefrontal cortices develop a severe impairment in real-life decision-making, in spite of otherwise preserved intellect. The impairments are especially marked in the personal and social realms (Damasio, Tranel, & Damasio, 1991). Patient E.V.R. is a prototypical example of this condition. He often decides against his best interest, and is unable to learn *Corresponding author. Supported by NINDS PO1 NS19632 and the James S.
    [Show full text]
  • Neurology and Neurosurgery
    NYU Langone Medical Center 550 First Avenue, New York, NY 10016 nyulmc.org NEUROLOGY AND NEUROSURGERY 2014 YEAR IN REVIEW CONTENTS 1 Message from the Chairs 2 Facts & Figures 4 New & Noteworthy 8 Clinical Care 9 Cerebrovascular Surgery 24 Multiple Sclerosis Center 12 Stroke Center 26 Parkinson’s and Movement 13 Neuro ICU Disorders Center 14 Brain Tumor Center 28 Neuromodulation 16 Center for Advanced 30 Center for Cognitive Neurology Radiosurgery 32 Pediatrics 18 Concussion Center 34 Neurogenetics 19 Neuro-Ophthalmology 36 Neuromuscular 20 Comprehensive Epilepsy Center 37 Dysautonomia Center 23 Neurophysiology 38 Spine and Peripheral Nerve 23 Neuropsychology 39 General Neurology and Neuropsychiatry 40 Research 42 Education & Training 46 Publications Design: Ideas On Purpose, www.ideasonpurpose.com 51 Leadership Produced by: Office of Communications and Marketing, NYU Langone Medical Center NYU LANGONE MEDICAL CENTER / NEUROLOGY AND NEUROSURGERY / 2014 PAGE 1 MESSAGE FROM THE CHAIRS Dear Colleagues and Friends, We are pleased to present this inaugural annual report from the Departments of Neurology and Neurosurgery at NYU Langone Medical Center. This publication marks a time of significant growth for our departments: Patient volume has risen steadily, we have added stellar faculty members in key strategic areas, and our research and educational programs continue to expand. Today, all of our subspecialties are staffed by physician leaders, including many nationally and internationally recognized clinicians and researchers. Our divisions include one of the largest, most sophisticated epilepsy centers in the nation; the leading brain, skull-base, and cerebrovascular surgery programs in the New York area; nationally known centers for the treatment of multiple STEVEN L.
    [Show full text]
  • INTENSIVE CARE in NEUROLOGY and NEUROSURGERY Pathophysiological Basis for the Management of Acute Cerebral Injury
    Daniel Agustín Godoy INTENSIVE CARE IN NEUROLOGY AND NEUROSURGERY Pathophysiological Basis for the Management of Acute Cerebral Injury VOLUME 1 Head Editor Daniel Agustín Godoy, MD, FCCM Neurointensive Care Unit- Sanatorio Pasteur Intensive Care Unit Hospital Interzonal de Agudos ‘’San Juan Bautista’’ Catamarca. Argentina Associate Editor Gustavo Rene Piñero, MD, FCCM Intensive Care Unit Hospital Municipal ‘’Leonidas Lucero’’ Assistant Professor Critical and Emergency MedicineHealth Sciences Department - South University Bahia Blanca, Buenos Aires. Argentina © SEEd srl. All rights reserved Piazza Carlo Emanuele II, 19 – 10123 Torino, Italy Tel. 011.566.02.58 – Fax 011.518.68.92 www.edizioniseed.it [email protected] First edition February 2013 VOLUME 1 ISBN 978-88-9741-939-6 Printed on acid-free paper by Tipografia Graphot, Torino (Italy) Although the information about medication given in this book has been carefully checked, the author and publisher accept no liability for the accuracy of this information. In every individual case the user must check such information by consulting the relevant literature. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcast- ing, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publi- cation or parts thereof is permitted only under the provisions of the Italian Copyright Law in its current version, and permission for use must always be obtained from SEEd Medical Publishers Srl. Violations are liable to prosecution under the Italian Copyright Law. To my parents Mirtha and Justino for giving me the life, education and the opportunity to study and acquire this wonderful profession.
    [Show full text]
  • Myasthenia Gravis T E Myasthenia Gravis (MG) Is a Disorder Characterized by Weakness
    Neurology/NeuroSurgery Stephen B. Lane, DVM Diplomate ACVIM-Specialty of Neurology Veterinary Neurology/Neurosurgery S Myasthenia Gravis t e Myasthenia gravis (MG) is a disorder characterized by weakness. The weakness can involve the leg muscles and swallow tube (esophagus) of the body p generalized form or selectively involve the muscles of the face and swallow tube in the regional form of the disease. MG may be present at birth, congenital, or develop after birth in the acquired form of the disease. h e Muscles function by contracting when stimulated by nerves, resulting in the movement of bones they are attached to. Individual muscle cells, myofibers, are dependent upon the nerves to stimulate them to contract. Nerves supply this stimulation by converting their electrical impulses into chemical n transmission. A specialized gap, or junction (neuromuscular junction) separates the nerve ending from the muscle membrane. To allow electrical transmission to reach the muscle membrane, a small amino acid complex, neurotransmitter, produced in the nerve ending is released and acts as a messenger in transmitting the stimulating impulse from the nerve to the muscle. The neurotransmitter called acetylcholine, binds to specialized regions B of the muscle membrane called acetylcholine receptors (Ach-R). If enough Ach-R bindings occur, the muscle will depolarize and the muscle will . contract causing movement. Etiology L Congenital MG is a genetic condition characterized by a lack of Ach-R. Acquired MG is an autoimmune disease where defense products (antibodies) are a produced against the acetylcholine receptors of the muscle after birth, resulting in destruction and loss of many of the Ach-receptors.
    [Show full text]
  • Neuroradiology Curriculum in Neurology Residency Training Programs How We Teach Neuroimaging
    RESIDENT & FELLOW SECTION Education Research: Neuroradiology curriculum in neurology residency training programs How we teach neuroimaging Paul D. Johnson, MD, Stefan Sillau, PhD, Joseph C. Masdeu, MD, PhD, Douglas E. Ney, MD, Correspondence and Pearce J. Korb, MD Dr. Johnson [email protected] Neurology® 2019;92:199-203. doi:10.1212/WNL.0000000000006812 Abstract Objective To better understand how the essential skill of interpreting various neuroimaging studies is taught to neurology residents in Accreditation Council for Graduate Medical Education (ACGME)-accredited training programs. Methods A 22-question survey was sent electronically to 150 ACGME adult neurology program directors. We collected data regarding the presence of a neuroimaging curriculum, frequency of review sessions and testing, resource availability, and program director confidence in neuro- imaging skills of graduating residents. We collected average scores on the neuroimaging section of the Resident In-service Training Examination of graduating residents for the past 3 years, which we attempted to correlate with resource availability. Results One-third of neurology residency programs do not have a neuroimaging curriculum, and half of training programs do not require a neuroimaging rotation. On average, trainees spend 1 hour per week reviewing imaging with radiologists. Program directors believed trainees receive insufficient neuroimaging training, with a median satisfaction rating on a Likert scale (0–100) of 35 (interquartile range 27–47). Few programs take advantage of online training resources. Conclusion Opportunities exist to improve neuroimaging education in neurology resident education. This can be done by closer adherence to the American Academy of Neurology neuroimaging curriculum guidelines, especially by expanding access to online resources and additional em- phasis on imaging review with neurology subspecialists.
    [Show full text]