Longevity Perceptions and Drivers: How Americans View Life Expectancy
Total Page:16
File Type:pdf, Size:1020Kb

Load more
Recommended publications
-
Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes
Sound Decisions: An Undergraduate Bioethics Journal Volume 2 Issue 1 Article 4 2016-12-15 Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes Eric Ralph University of Puget Sound Follow this and additional works at: https://soundideas.pugetsound.edu/sounddecisions Part of the Bioethics and Medical Ethics Commons Recommended Citation Ralph, Eric (2016) "Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes," Sound Decisions: An Undergraduate Bioethics Journal: Vol. 2 : Iss. 1 , Article 4. Available at: https://soundideas.pugetsound.edu/sounddecisions/vol2/iss1/4 This Article is brought to you for free and open access by the Student Publications at Sound Ideas. It has been accepted for inclusion in Sound Decisions: An Undergraduate Bioethics Journal by an authorized editor of Sound Ideas. For more information, please contact [email protected]. Ralph: Longevity Extension Longevity Extension from a Socioeconomic Perspective: Plausibility, Misconceptions, and Potential Outcomes Eric Ralph Introduction In the last several decades, a significant amount of progress has been made in pursuits to better understand the process of aging and subsequently gain some level of control over it. Current theories of aging are admittedly lacking, but this has not prevented biogerontologists from drastically increasing the longevity of yeast, drosophilae, worms, and mice (Vaiserman, Moskalev, & Pasyukova 2015; Tosato, Zamboni et al. 2007; Riera & Dillin 2015). Wide-ranging successes with gene therapy and increased comprehension of the genetic components of aging have also recently culminated in numerous successes in extending the longevity of animals and the first human trial of a gene therapy to extend life through telomerase manipulation is already underway, albeit on a small scale (Mendell et al. -
World Population Ageing 2019
World Population Ageing 2019 Highlights ST/ESA/SER.A/430 Department of Economic and Social Affairs Population Division World Population Ageing 2019 Highlights United Nations New York, 2019 The Department of Economic and Social Affairs of the United Nations Secretariat is a vital interface between global policies in the economic, social and environmental spheres and national action. The Department works in three main interlinked areas: (i) it compiles, generates and analyses a wide range of economic, social and environmental data and information on which States Members of the United Nations draw to review common problems and take stock of policy options; (ii) it facilitates the negotiations of Member States in many intergovernmental bodies on joint courses of action to address ongoing or emerging global challenges; and (iii) it advises interested Governments on the ways and means of translating policy frameworks developed in United Nations conferences and summits into programmes at the country level and, through technical assistance, helps build national capacities. The Population Division of the Department of Economic and Social Affairs provides the international community with timely and accessible population data and analysis of population trends and development outcomes for all countries and areas of the world. To this end, the Division undertakes regular studies of population size and characteristics and of all three components of population change (fertility, mortality and migration). Founded in 1946, the Population Division provides substantive support on population and development issues to the United Nations General Assembly, the Economic and Social Council and the Commission on Population and Development. It also leads or participates in various interagency coordination mechanisms of the United Nations system. -
Longevity and Life Expectancy
LONGEVITY AND LIFE EXPECTANCY Cesare Marchetti International Institute for Applied Systems Analysis Laxenburg, Austria RR-97-11 September 1997 Reprinted from Technological Forecasting and Social Change, Volume 55, Number 3, July 1997. International Institute for Applied Systems Analysis, Laxenburg, Austria Tel: +43 2236 807 Fax: +43 2236 73148 E-mail: [email protected] Reseai·ch R e poi-ts , which record research conducted a.t ILA.SA , a.re independently reviewed before publication. Views or opinions expressed herein do not necessarily represent those of the Institute, its Na.tiona.l Member Orga.niza.tions, or other orga.niza.tions supporting the work. Reprinted with permission from Technological Forecasting and Social Change, Volume 55, Number 3, July 1997. Copyright @1997, Elsevier Science Inc. All rights reserved. No pa.rt. of this publica.tion ma.y be reproduced or transmitted in a.ny form or by a.ny means, electronic or mecha.nica.l, including photocopy, recording, or a.ny information storage or retrieval system, without permission in writing from the copyright holder. NORTH-HOLLAND Longevity and Life Expectancy CESARE MARCHETTI ABSTRACT The increase in life expectancy at all ages during the last two centuries is in need of a quantitative model capable of resuming the whole process under a single concept and simple mathematics. The basic hypothesis was that through improved hygiene, medicine, and life-style, the stumbling blocks to the full expression of longevity were progressively removed. The mathematics of learning processes was then applied to the secular evolution of life expectancy at various ages. The hypothesis proved very fertile. -
Addressing the Value of Gene Therapy and Enhancing Patient Access to Transformative Treatments
Position Statement Addressing the Value of Gene Therapy and Enhancing Patient Access to Transformative Treatments Rachel Salzman,1,7 Francesca Cook,2,7 Timothy Hunt,3,7 Harry L. Malech,4,7 Philip Reilly,5,7 Betsy Foss-Campbell,6 and David Barrett6 1ALD Connect, Middleton, MA, USA; 2REGENXBIO Inc., Rockville, MD, USA; 3Editas Medicine, Inc., Cambridge, MA, USA; 4Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA; 5Third Rock Ventures, Boston, MA, USA; 6American Society of Gene and Cell Therapy, Milwaukee, WI, USA; 7American Society of Gene and Cell Therapy, Value Initiative Workgroup, Milwaukee, WI, USA Although high upfront costs for the high value of gene therapy today versus paying repeatedly for treatments that may be taken at have resulted in concerns about sufficient reimbursement to regular intervals for months, years, decades, or even a lifetime. But as- allow patient access to these therapies, the significant benefits signing value to gene therapies and comparing them with potentially of gene therapies will not be realized unless patients have access lifelong illness is not an easy or straightforward task. Despite the to them. Stakeholders are discussing these issues, and the complexity, this paper identifies unique and relevant aspects that payment models being developed for the newly approved should be considered when assessing the value of gene therapy. gene therapies provide an early indication of the flexibility A related important discussion is how the costs of these treatments that will be needed from treatment manufacturers, payers, could be reduced, and whether the cost of gene therapy products and policy makers to optimize patient access. -
Dissecting Aging and Senescence—Current Concepts and Open Lessons
cells Review Dissecting Aging and Senescence—Current Concepts and Open Lessons 1,2, , 1,2, 1 1,2 Christian Schmeer * y , Alexandra Kretz y, Diane Wengerodt , Milan Stojiljkovic and Otto W. Witte 1,2 1 Hans-Berger Department of Neurology, Jena University Hospital, 07747 Jena, Thuringia, Germany; [email protected] (A.K.); [email protected] (D.W.); [email protected] (M.S.); [email protected] (O.W.W.) 2 Jena Center for Healthy Ageing, Jena University Hospital, 07747 Jena, Thuringia, Germany * Correspondence: [email protected] These authors have contributed equally. y Received: 2 October 2019; Accepted: 13 November 2019; Published: 15 November 2019 Abstract: In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of reduced fitness, risk for disease acquisition, and death. Similarly unanswered are the questions of whether aging is reversible and can be turned into rejuvenation as well as how aging is distinguishable from and influenced by cellular senescence. With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Here, we provide a factor-based comparison of current knowledge on aging and senescence, which we converge on four suggested concepts, thereby implementing the newly emerging cellular and molecular aspects of geroconversion and amitosenescence, and the signatures of a genetic state termed genosenium. -
Living to 100”
The Likelihood and Consequences of “Living to 100” Leonard Hayflick, Ph.D. Professor of Anatomy, Department of Anatomy University of California, San Francisco, School of Medicine Phone: (707) 785-3181 Fax: (707) 785-3809 Email: [email protected] Presented at the Living to 100 Symposium Orlando, Fla. January 5-7, 2011 Copyright 2011 by the Society of Actuaries. All rights reserved by the Society of Actuaries. Permission is granted to make brief excerpts for a published review. Permission is also granted to make limited numbers of copies of items in this monograph for personal, internal, classroom or other instructional use, on condition that the foregoing copyright notice is used so as to give reasonable notice of the Society’s copyright. This consent for free limited copying without prior consent of the Society does not extend to making copies for general distribution, for advertising or promotional purposes, for inclusion in new collective works or for resale. Abstract There is a common belief that it would be a universal good to discover how to slow or stop the aging process in humans. It guides the research of many biogerontologists, the course of some health policy leaders and the hopes of a substantial fraction of humanity. Yet, the outcome of achieving this goal is rarely addressed despite the fact that it would have profound consequences that would affect virtually every human institution. In this essay, I discuss the impact on human life if a means were found to slow our aging process, thus permitting a life expectancy suggested by the title of this conference, “Living to 100.” It is my belief that most of the consequences would not benefit either the individual or society. -
Mortality Improvements and Evolution of Life Expectancies
Mortality improvements and evolution of life expectancies Adrian Gallop Actuary, Pensions policy, Demography and Statistics UK Government Actuary’s Department Finlaison House 15-17 Furnival Street London EC4A 1AB United Kingdom Tel +44 20 7211 2635 e-mail: [email protected], or [email protected] 1 Mortality in the United Kingdom – 20th century trends During the course of the 20th century, the United Kingdom saw a continuation of the pattern of falling death rates that began around the beginning of the 19th century. Over these two centuries there has been a change from a regime of high infant and child mortality, with a preponderance of acute and infectious diseases, to a new regime in which adult mortality predominates and chronic and degenerative diseases are the most common causes of death. Period life expectancy at birth in the mid-19th century was around 40 years for males and 42 years for females. These figures increased to around 45 and 50 years respectively by 1901. Life expectancy then rose dramatically until the mid- 1950s. Since then, life expectancy at birth has continued to increase but at a less rapid rate (see Fig 1). Life expectancy for males rose at a lower rate than for females during the 1950s and 1960s, with the difference between males and females rising to a high of 6.3 years in 1970. Since 1970, male expectation of life has been increasing faster than female and the differential has fallen to 4.4 years by 2003. Figure 1: Period expectation of life at birth, England and Wales, 1850-2003 90 80 70 60 50 Ma l e s Expectation of life (years) of Expectation Females 40 30 1850 1860 1870 1880 1890 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 Year 2 Tables 1 and 2 show how period life expectancies for England and Wales have changed over the 20th century for selected ages. -
New England Centenarian Study Updates Medical Campus: We Hope This Newsletter Finds You and Your Family Well
Our contact November 2017 information at the Boston University New England Centenarian Study Updates Medical Campus: We hope this newsletter finds you and your family well. We’ve been The New England quite busy since our last newsletter with conferences, new research Centenarian Study publications, new participants, and new research partnerships as well as Boston University some staff changes to tell you about. We deeply value your help with Medical Campus our studies ,and to our participants, obviously none of what we do 88 East Newton Street would be possible without you! Robinson 2400 Boston, MA 02118 Our Toll-free Number: 888-333-6327 Pennsylvania, who is also the sec- ond oldest person ever in the world! Thomas T. Perls, MD, Of special note, we also enrolled MPH Sarah’s daughter Kitty at the age of 617‐638‐6688 Email: [email protected] 99 years and Kitty herself went on to become a centenarian. Stacy Andersen, PhD 617‐638‐6679 Sisters Mildred MacIsaac & Agnes Buckley, ages of 100 years and 103 Email: [email protected] years, were kind enough to pose for a photo shoot for Boston Julia Drury, BS Magazine which highlighted the 617-638-6675 Study’s recent findings Email: [email protected] Study Participant Recruitment Sara Sidlowski, BS Since beginning our research in 617-638-6683 Sarah Knauss, seated on the left, as 1996, we have enrolled approxi- Email: [email protected] the second oldest ever person in mately 2,500 centenarians includ- the world at age 119 years. Sarah is ing 150 supercentenarians (people the oldest participant in the New England Centenarian study. -
Increase of Human Longevity: Past, Present and Future
Increase of Human Longevity: Past, Present and Future John R. Wilmoth Department of Demography University of California, Berkeley Instute for Populaon and Social Security Research Tokyo, Japan 22 December 2009 Topics • Historical increase of longevity • Age paerns of mortality • Medical causes of death • Social and historical causes • Limits to the human life span? • Future prospects Historical Increase of Longevity Life Expectancy at Birth, 1950-2009 Data source: United Nations, World Population Prospects: 2008 Revision, 2009 Life Expectancy at Birth, France, 1816-2007 Data source: Human Mortality Database, 2009 (www.mortality.org) Life Expectancy at Birth, France and India, 19th and 20th C. Data sources: HMD, 2009; M. Bhat, 1989, 1998 & 2001; United Nations, 2009 Life Expectancy at Birth, 1950‐2007 W. Europe, USA, Canada, Australia, NZ, Japan Data source: Human Mortality Database, 2009 (www.mortality.org) Historical mortality levels Life expectancy Infant mortality rate at birth (in years) (per 1000 live births) Prehistoric 20-35 200-300 Sweden, 1750s 36 212 India, 1880s 25 230 U.S.A., 1900 48 133 France, 1950 66 52 Japan, 2007 83 <3 Source: J. Wilmoth, Encyclopedia of Population, 2003 (updated) Age Paerns of Mortality Death Rates by Age, U.S., 1900 & 1995 Data source: Social Security Administraon, United States Distribuon of Deaths, U.S., 1900 & 1995 Data source: Social Security Administraon, United States Probability of Survival, U.S., 1900 & 1995 Data source: Social Security Administraon, United States Dispersion of Ages at Death vs. Life Expectancy at Birth, Sweden 1751‐1995 70 80 60 70 Life Expectancy at Birth (in years) 50 Inter-quartile range 60 40 Life expectancy at birth 50 30 40 Inter-quartile Range (in years) 20 Women Men 30 1751-55 1791-95 1831-35 1871-75 1911-15 1951-55 1991-95 Year Source: J. -
Nebraska's 37 Supercentenarians Validated Among World's Longest-Lived
Nebraska’s 37 Supercentenarians Validated Among World’s Longest-Lived by E. A. Kral Updated Oct. 3, 2018 Since publication of the author's 44-page supplement "Nebraska's Centenarians Age 107 Or Above--1867 to 2001" in the April 24, 2002, Crete News and follow-up article on the state's supercentenarians published in the October 2, 2002, Crete News, more longevity claims have been validated for persons who have Nebraska connections by birth or by residence and have reached age 110 or above. For validation of longevity claims, three records are usually needed from the first 20 years of a person's life, including such sources as birth registration, baptismal record, census data, or marriage certificate. The author was able to validate--with assistance from Gerontology Research Group scholars and volunteers--all the individual supercentenarian reports that follow, along with a brief summary for each. Clara Herling Huhn (1887-2000) Born near Clarkson, Colfax County, she died at La Mesa, California at the age of 113 years and 327 days. She lived the first 51 years of her life in Colfax County, and is the longest-lived Nebraska native. To date, she is the oldest person in Nebraska history, and as of March 2012, she ranked among the top 100 oldest persons in world history, according to Gerontology Research Group based in Los Angeles. Ella Winkelmann Schuler (1897 - 2011) Born near Fontanelle, Washington County, Nebraska, she died at Topeka, Kansas at the age of 113 years and 244 days. She moved to Hooper, Dodge County in 1917, where she was married in 1923, then lived near Denver, Colorado and Page City, Thomas County, Kansas until 1934, when she relocated to Topeka. -
Provisional Life Expectancy Estimates for January Through June, 2020
Vital Statistics Rapid Release Report No. 010 February 2021 Provisional Life Expectancy Estimates for January through June, 2020 Elizabeth Arias, Ph.D., Betzaida Tejada-Vera, M.S., and Farida Ahmad, M.P.H. Introduction Keywords: life expectancy • Hispanic Results origin • race • National Vital Statistics The National Center for Health System Statistics (NCHS) collects and Life expectancy in the United disseminates the nation’s official vital States statistics through the National Vital Data and Methods The Table summarizes life expectancy Statistics System (NVSS). NCHS uses Provisional life expectancy estimates by age, Hispanic origin, race, and sex. provisional vital statistics data for were calculated using abridged period Life expectancy at birth represents the conducting public health surveillance life tables based on provisional death average number of years that a group and final data for producing annual counts for the first half of 2020 from of infants would live if they were to national natality and mortality statistics. death records received and processed experience throughout life the age- NCHS publishes annual and decennial by NCHS as of October 26, 2020; specific death rates prevailing during national life tables based on final vital provisional numbers of births for the a specified period. In the first half of statistics. In order to assess the effects same period based on birth records 2020, life expectancy at birth for the on life expectancy of excess mortality received and processed by NCHS as total U.S. population was 77.8 years, observed during 2020, NCHS is of October 27, 2020; and, April 1, declining by 1.0 year from 78.8 in 2019 publishing, for the first time, life tables 2020 monthly postcensal population (6). -
Longevity Rejuvenation & Anti Ageing
LONGEVITY REJUVENATION & ANTI AGEING MINIMUM DURATION 10 nights Get a unique Longevity Anti Ageing Check Up. Enjoy a high impact, intense detox, repair and regeneration programme for your holistic health and wellbeing, while boosting your immune system, cellular health and overall vitality. +351 935 619 759 . [email protected] longevityalvor.com LONGEVITY REJUVENATION & ANTI AGEING MINIMUM DURATION 10 nights . Access to the Detox & Relax wet area circuit / 10 Full Board Wellness (up to 5 meals per day): (infra-red sauna, hammam, ice fountain, Epson including morning and afternoon snacks, and healthy and tasty lunch and dinner. Liquid Diet salt room, sensations showers, relaxing room, (detoxifying & anti-inflammatory shakes, juices relax walking path, indoor heated detox pool, and soups), subject to doctor or nutritionist’s indoor sensation relax pool) approval / 1 Detox Kit (enema, detox supplements, detox . Access to the Longevity Vitality activity plan daily teas group activities – Examples of activities: yoga, / Longevity infusions, alkaline water ph 9.5, pilates, stretching, core training, tone & fit, jump, and aromatherapy essential oil fit ball, walks, among others . Access to the gym . Health & Wellness programme: +351 935 619 759 . [email protected] longevityalvor.com LONGEVITY REJUVENATION & ANTI AGEING MINIMUM DURATION 10 nights / 1 Longevity Holistic Health Check, including: / 1 Longevity Anti Ageing Check-Up . Lifestyle evaluation / 1 Integrative Medicine and Anti-Ageing . Biophysical evaluation (weight, BMI, fat mass, Consultation muscle mass, visceral fat, abdominal perimeter, metabolic age) / 1 Traditional Chinese Medicine Consultation . Nutritional and wellbeing evaluation / 2 Ozone & Oxygen-Therapy Session (IV) . Fitness profile evaluation . Heavy metals evaluation / 2 Ozone & Oxygen-therapy Body Session (Sauna) .